Podcasts about methemoglobinemia

Send us a Text Message.We are in the mountains and foothills of Kentucky this week. Donald Harvey, known as the "Angel of Death" from Kentucky, confessed to causing at least 37 deaths, with some believing there were even more. For 17 years, he worked in hospitals, where his secretive and deadly methods left many unanswered questions. The Blue Fugates of Kentucky, a family whose skin turned blue due to a rare genetic condition, have intrigued scientists and locals alike for generations. Their mysterious blue hue, passed down through generations, begs the question: what other secrets lie within their unique genetic makeup? Join us as we unravel the dark and intriguing mysteries of Kentucky's past and explore the fascinating stories that continue to captivate and puzzle to this day. --Follow us on Social Media and find out how to support A Scary State by clicking on our Link Tree: https://instabio.cc/4050223uxWQAl--Have a scary tale or listener story of your own? Send us an email to ascarystatepodcast@gmail.com! We can't wait to read it!--Thinking of starting a podcast? Thinking about using Buzzsprout for that? Well use our link to let Buzzsprout know we sent you and get a $20 Amazon gift card if you sign up for a paid plan!https://www.buzzsprout.com/?referrer_id=1722892--Works cited!https://docs.google.com/document/d/1yta4QOa3v1nS3V-vOcYPNx3xSgv_GckdFcZj6FBt8zg/edit?usp=sharing --Intro and outro music thanks to Kevin MacLeod. You can visit his site here: http://incompetech.com/. Which is where we found our music!

Show notes at pharmacyjoe.com/episode920. In this episode, I’ll discuss what blood gas parameters can make you suspect methemoglobinemia. The post 920: What blood gas parameters indicate possible methemoglobinemia? appeared first on Pharmacy Joe.

Episode Summary: In this revelatory episode of Functional Health Radio, Dr. Kristin Hieshetter delves into the intriguing world of a compound that gained its origins in the textile industry and has since emerged as a powerhouse in the medical field—methylene blue. With the ability to tackle a spectrum of health issues from chronic diseases to mental decline, methylene blue represents a beacon of hope and potential. Dr. Hieshetter eloquently outlines how this compound, methylthioninium chloride, transcended its textile dye beginnings to become a crucial element in combatting diseases such as malaria and various types of viral infections. Allying with researcher Mark Sloan's insights, Dr. Hieshetter sheds light on methylene blue's profound impact on mitochondrial efficiency, which in turn seems to accelerate the body's healing processes and cognitive functions. The episode culminates with personal anecdotes and studies that signify the compound's prominence in a new era of health optimization. Key Takeaways: Methylene blue, originally a textile dye, has significant medical applications for treating malaria, poisonings, and chronic diseases. The compound facilitates increased mitochondrial efficiency, enhancing oxygen circulation and ATP production, integral for disease prevention and treatment. It has shown potential in improving brain functions, with increased memory and cognitive abilities reported after ingestion. Usage of methylene blue among cancer patients during the COVID-19 pandemic resulted in none contracting the virus, signifying its capability as a viral inhibitor. Personal experiences suggest immediate benefits, including pain reduction and enhanced energy levels after methylene blue intake. Notable Quotes: "We are walking around in the most amazing, intelligent, responsive, adapting, and aware system in the world, the human body." "Imagine how groundbreaking this is. Everybody think about getting malaria. That's kind of a death sentence before modern medicine." “Methylene blue...it's the only drug known to inhibit the excessive production of reactive oxygen species and cytokines." "If we can just create a tipping point of people in our population who really understand, hey, I'm in the driver's seat of my own body." Resources: Methylene blue references can be found on pubmed.com for further reading. “The Ultimate Guide to Methylene Blue” by Mark Sloan is a book recommended for detailed insights into the applications of methylene blue. Let your curiosity take the lead and tune in to this fascinating episode of Functional Health Radio with Dr. Kristin Hieshetter. Discover more empowering content and breakthrough conversations, always at the frontier of functional health and wellness. Stay informed, stay inspired, and unlock your true potential with each listen.

In this episode, we review the high-yield topic of ⁠⁠⁠⁠Methemoglobinemia from the Pulmonary section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets

In Deuteronomy God promises to raise up a prophet like Moses, who will speak for God; in Psalm 111 God shows the people the power of God's works. For the church these are ways of pointing to the unique authority people sensed in Jesus' actions and words. We encounter that authority in God's word, around which we gather, the word that prevails over any lesser spirit that would claim power over us, freeing us to follow Jesus.Scripture Readings: Deuteronomy 18:15-20; Psalm 111; Mark 1:21-28

Jess and Alice turn into marine biologists this week as they dissect a Harrow episode about jellyfish and shark attacks. There are plenty of forensics points to go around here, especially the true murder mystery shark attack story at the end of the episode. Episode information: Harrow Season 2 Episode 4:  Follow us on Instagram: @insidethemorguepod Email us show suggestions: insidethemorguepod@gmail.com If you enjoy this podcast, support us! Music used from Pixabay.com: Crime Trap by Muzaproduction & Detective by SergeQuadrado Sources: https://my.clevelandclinic.org/health/diseases/24115-methemoglobinemia#:~:text=Methemoglobinemia%20(MetHb)%20is%20a%20rare,methemoglobinemia%20can%20be%20life%20threatening. https://medlineplus.gov/ency/article/000821.htm#:~:text=INFLAMMATION,into%20the%20tissues%2C%20causing%20swelling. https://www.law.cornell.edu/wex/inadmissible_evidence https://www.indeed.com/career-advice/career-development/different-types-of-evidence#:~:text=Inadmissible%20evidence&text=Forms%20of%20evidence%20judges%20consider,the%20events%20of%20a%20case. https://www.reviewofoptometry.com/article/cs-eye https://gizmodo.com/3-000-year-old-murder-mystery-solved-shark-attack-1847194903 https://www.sciencedirect.com/science/article/abs/pii/S2352409X21002777?dgcid=author --- Support this podcast: https://podcasters.spotify.com/pod/show/insidethemorgue/support

Show notes at pharmacyjoe.com/episode808. In this episode, I ll discuss the dose of methylene blue for the treatment of acquired methemoglobinemia. The post 808: How To Dose Methylene Blue For the Treatment of Acquired Methemoglobinemia appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode808. In this episode, I'll discuss the dose of methylene blue for the treatment of acquired methemoglobinemia. The post 808: How To Dose Methylene Blue For the Treatment of Acquired Methemoglobinemia appeared first on Pharmacy Joe.

Want to experience the greatest in board studying? Check out our interactive question bank podcast- the FIRST of its kind here: emrapidbombs.supercast.com. Cite this podcast as: Briggs, Blake; Husain, Ilitfat. Episode 167. Methemoglobinemia: like a box of chocolates. https://www.emboardbombs.com/podcasts/167-methemoglobinemia-like-a-box-of-chocolates. February 27th, 2023. Accessed [date]

$5 Q-BANK: https://www.patreon.com/highyieldfamilymedicine Intro 0:30, Sickle cell anemia 1:34, Thalassemia 9:03, Hereditary spherocytosis 15:36, G6PD deficiency 17:38, Pyruvate kinase deficiency 19:27, Microangiopathic hemolytic anemia 20:08, Autoimmune hemolytic anemia 24:56, Paroxysmal nocturnal hemoglobinuria 26:59, Blood transfusion reactions 28:31, Drug-induced hemolysis 30:05, Malaria 30:42, Babesiosis 31:47, Iron deficiency anemia 32:34, Megaloblastic anemia 35:34, Lead poisoning 37:59, Porphyria 39:07, Sideroblastic anemia 40:01, Aplastic anemia 41:23, Polycythemia 45:24, Methemoglobinemia 46:34, Carbon monoxide poisoning 47:56, Hemophagocytic lymphohistiocytosis 48:48, Practice questions 49:34

Take Home Points Methemoglobinemia can result from exposure to a number of different medications. The most common are dapsone and topical anesthetic agents (i.e. benzocaine) Consider the diagnosis in any patient with cyanosis and hypoxia that doesn't respond to oxygen administration Administer methylene blue to any patient with abnormal vital signs, metabolic acidosis, end organ ... Read more The post REBEL Core Cast 90.0 – Methemoglobinemia appeared first on REBEL EM - Emergency Medicine Blog.

In this episode, we review the high-yield topic of Methemoglobinemia from the Hematology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbulletsIn --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

We've all heard of the Blue Moon of Kentucky thanks to Elvis Presley, Kentucky Blue Grass, and Kentucky Blue is even a color of paint... But this is an entirely different type of blue; The Blue Fugates. They are a family with a rare blood disorder called methemoglobinemia. It can cause blue skin, and boy did it. Four of their seven children exhibited blue skin so the family retreated from society... and inbred over and over until they became world renowned for this hue. What happened to them? Can it be treated?  And how can you turn yourself blue from the comfort of your own home? We answer those questions and many even crazier this from the preverbal cornucopia of weird, Kentucky. Special thanks to this week's sources:Cover Art By;Joshua LernerBooks and ArticlesHereditary Diaphorase Deficiency and Methemoglobinemia - https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/570011The Book Woman of Troublesome Creek | Kim Michele RichardsonBlue-Skinned Gods | S. J. SinduVideosMystery of the Fugate Family: The Blue People of Kentucky - https://youtu.be/3GYMFKs_6TsWebsitesBlue Fugates - https://en.wikipedia.org/wiki/Blue_FugatesFamily Aggregation - https://en.wikipedia.org/wiki/Family_aggregationArgyria - https://en.wikipedia.org/wiki/ArgyriaScience Classroom Teacher Resources - https://www.nclark.net/BluePeopleofTroublesomeCreekWired - https://www.wired.com/story/does-colloidal-silver-work/How Stuff Works - https://health.howstuffworks.com/human-body/systems/circulatory/blue-people-kentucky.htmABC News - https://abcnews.go.com/Health/blue-skinned-people-kentucky-reveal-todays-genetic-lesson/story?id=15759819Email us your favorite WEIRD news stories:weird@hysteria51.comSupport the ShowGet exclusive content & perks as well as an ad and sponsor free experience at https://www.patreon.com/Hysteria51 from just $1Join Our Discord Serverhttps://discord.gg/WuPKAZ6cpgShopBe the Best Dressed at your Cult Meeting!https://www.teepublic.com/stores/hysteria-51?ref_id=4106 See omnystudio.com/listener for privacy information.

Show notes at pharmacyjoe.com/episode680. In this episode, I ll discuss what blood gas parameters can make you suspect methemoglobinemia. The post 680: What blood gas parameters can make you suspect methemoglobinemia? appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode680. In this episode, I'll discuss what blood gas parameters can make you suspect methemoglobinemia. The post 680: What blood gas parameters can make you suspect methemoglobinemia? appeared first on Pharmacy Joe.

In this episode we take a deep dive on methemoglobinemia. We discuss when to suspect it, diagnosis, treatment, and some great medical trivia! Written by:  Dr. Lorenzo Madrazo (Internal Medicine Resident) Reviewed by: Dr. Andrew Appleton (General Internal Medicine) and Dr. Wael Haddara (Critical Care)

Got bit by a rattlesnake or eat a poisonous mushroom and looking for an antidote? Look no further than the wonder-drug methylene blue – a medicinal blue dye that acts as an antidote for chemical poisoning and overdose. In this presentation, you'll learn how and why methylene blue can be used as an antidote for all types of chemical poisonings or drug overdoses. Also included is the exact dose used by hospital as an antidote to chemical poisoning. Link to article: https://www.endalldisease.com/methylene-blue-miracle-antidote-for-poisonings-and-overdoses My #1 Bestselling books: https://endalldisease.com/books

Caso clínico de uma síndrome comum! Qual a sua abordagem para um paciente com hipoxemia? Pedro apresenta esse caso para Iago e João que trazem uma abordagem prática! Dúvidas, críticas ou sugestões? Entra em contato pelo Instagram ou Twitter @tadeclinicagem MINUTAGEM (2:30) Início do Caso (3:10) Abordagem inicial (5:28) Indicações de via aérea definitiva (7:53) Continuação do caso (11:35) Inicio do raciocínio (13:35) Parte do exame físico e seguimento do raciocínio (14:15) Abordagem prática da hipoxemia (32:50) Revisão dos passos (35:10) Exames solicitados (36:00) Final do caso (38:16) Resposta do desafio da semana anterior (38:55) Desafio da semana (39:15) Salves FÓRMULAS PAO2 = Pressão de oxigênio no álveolo PaO2 = Pressão de oxigênio na artéria FiO2 = Fração inspirada de oxigênio Patm = Pressão atmosférica PH2O = Pressão parcial de água PaCO2 = Pressão parcial de CO2 R = quociente respiratório Cálculo da PAO2 PAO2 = (FiO2 x [Patm - PH2O]) - (PaCO2 ÷ R) Gradiente Alvéolo-Arterial de Oxigênio PAO2 - PaO2 Valor normal do Gradiente Alvéolo-Arterial de Oxigênio (Referência: New England Journal of Medicine) Menor ou igual à (Idade / 4) + 4 Regra prática ao nível do mar para o cálculo do Gradiente 150 - (PaCO2 x 1,25) - PaO2 Regra prática ao nível de São Paulo (760m de altitude) para o cálculo do Gradiente 130 - PaCO2 - PaO2 Caso clínico retirado de: Marinacci, Lucas X., et al. "Case 38-2020: A 52-Year-Old Man with Cancer and Acute Hypoxemia." New England Journal of Medicine 383.24 (2020): 2372-2383. REFERÊNCIAS 1. Theodore, Arthur. Measures of oxygenation and mechanisms of hypoxemia. Acesso em uptodate.com 2. Mechem, Crawford. Pulse oximetry. Acesso em uptodate.com 3. Prchal, Josef. Methemoglobinemia. Acesso em uptodate.com

This week we discuss methemoglobinemia with Dr. KC Lee, a clinical pharmacist who recently completed her clinical toxicology/ emergency medicine fellowship.* Note: Although rare, there has been a slight increase in hydroxychloroquine-associated methemoglobinemia in the setting of COVIDReferences:Price DP, Howland MA. Methemoglobin inducers and methylene blue. Goldfrank's Toxicologic Emergencies 9th edition: 1698-1710. McGraw-Hill; New York: 2011Methemoglobin. Hennepin Regional Poison Center Treatment Guidelines. Minnesota Poison Control System. Accessed 9/22/2020

Methemoglobinemia after local anesthesia by AORNJournal

Methemoglobinemia

In this episode we cover that rare but fun element to your cyanosed patient Ddx. When your hemoglobin gets oxidized to Fe3+, badness can ensure. Enjoy this quick refresher.

    Your eyes may fool you...   Keep your differential diagnosis open.       Selected References   Aravindhan N, Chisholm DG. Sulfhemoglobinemia presenting as pulse oximetry desaturations. Anesthesiology. 2000;93:883–884.   Gharahbaghian L et al. Methemoglobinemia and Sulfhemoglobinemia in Two Pediatric Patients after Ingestion of Hydroxylamine Sulfate. West J Emerg Med. 2009 Aug; 10(3): 197–201    Ginimuge PR et al. Methylene Blue: Revisited. J Anaesthesiol Clin Pharmacol. 2010 Oct-Dec; 26(4): 517–520.    Mack E. Focus on diagnosis: co-oximetry. Pediatr Rev. 2007;28:73–4. So T-Y et al. Topical Benzocaine-induced Methemoglobinemia in the Pediatric Population. J Pediatr Health Care. 22(6):335–339.  

We discuss the curious case of the Blue Fugates, a clan from Kentucky with a mysterious condition that caused them to appear completely blue. Listen and find out the story behind their blueness and how has appeared throughout history and around the world.

Methemoglobinemia (January 2007) by Oregon 1-800-222-1222

Podcast summary of articles from the May 2018 edition of Journal of Emergency Medicine from the American Academy of Emergency Medicine.  Topics include D-dimer evaluation for Pulmonary Embolism, Propofol for pediatric headaches, Diabetic Ketoacidosis treatment in adults, a case report on a toxidrome in pregnancy and board review on pharyngitis mimics.  Guest speaker is Dr. Prashanth Swamy from the Metrohealth Emergency Medicine Residency.

Author: Nick Hatch, M.D. Educational Pearls:   Methemoglobinemia is when the iron in hemoglobin is in the Fe3+ (ferric) state rather than the normal Fe2+  (ferrous) state. Methemoglobin cannot release oxygen at the tissues. Symptoms include cyanosis, headache, tachycardia, dyspnea, and lethargy. Suspect in setting of hypoxia that does not improve with oxygenation, and clinical cyanosis with a normal PaO2 on ABG. Treatment is methylene blue which reduces the iron back to the ferrous state. Causes can be Dapsone, Lidocaine, Benzocaine.   References: Agarwal N, Nagel RL, Prchal JT. Dyshemoglobinemias. In: Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management, 2nd ed, Steinberg M (Ed), 2009. P.607 Cortazzo JA, Lichtman AD. (2014). Methemoglobinemia: a review and recommendations for management. Journal of Cardiothoracic and Vascular Anesthesia. 28:1043. Darling R, Roughton F. (1942). The effect of methemoglobin on the equilibrium between oxygen and hemoglobin. American Journal of Physiology. 137:56.

In this two-part episode, Sam Matz (MS3) sits down with Dr. Kusin, of Oregon Health and Science University in the department of Toxicology and Emergency Medicine. In part one, Dr. Kusin discusses a case report...

In this two-part episode, Sam Matz (MS3) sits down with Dr. Kusin, of Oregon Health and Science University in the department of Toxicology and Emergency Medicine. In part one, Dr. Kusin discusses a case report...

Methemoglobinemia may be induced by a variety of drugs including local anesthetics. Tune in to check out.   Subscribe to our mailing list * indicates required Email Address *     DISCLAIMER: Doctor Rosenblum IS HERE SOLELY TO EDUCATE, AND YOU ARE SOLELY RESPONSIBLE FOR ALL YOUR DECISIONS AND ACTIONS IN RESPONSE TO ANY INFORMATION CONTAINED HEREIN. This podcasts is not intended as a substitute for the medical advice of physician to a particular patient or specific ailment.  You should regularly consult a physician in matters relating to yours or another's health.  You understand that this podcast is not intended as a substitute for consultation with a licensed medical professional.    Copyright © 2017 QBazaar.com, LLC  All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, recording or otherwise, without the prior written permission of the author. References https://en.wikipedia.org/wiki/Methemoglobinemia

This week we discuss the rare but life-threatening methemoglobinemia with a focus on recognition and use of the antidote. https://media.blubrry.com/coreem/content.blubrry.com/coreem/Episode_97_0_Final_Cut.m4a Download 2 Comments Tags: Methemoglobin, Toxicology Show Notes Take Home Points MetHb –emia occurs as a results of various medications including amyl nitrite, dapsone, nitroprusside, phenazopyridine, sodium nitrite and topical anesthetics like benzocaine Patients will present with cyanosis, short of breath, fatigue, dizziness, weakness and ultimately CNS depression and death at higher concentrations. If you have a cyanotic/hypoxic patient that does not respond to supplemental oxygen, be concerned for MetHb and send a co-oximetry panel. If the level is 25% or the patient is symptomatic, you will treat with the antidote methylene blue given as a bolus of 1-2 mg/kg over 5 minutes And as always, make sure to call your local poison center to get your toxicologists involved. They can help with dosing, and they are also an important player of the public health component in cases such as these, to make sure this is an isolated incident and we don't have a repeat of the 11 blue men situation. Price DP. Chapter 127. Methemoglobin Inducers. In: Nelson LS, Lewin NA, Howland M, Hoffman RS, Goldfrank LR, Flomenbaum NE. eds. Goldfrank's Toxicologic Emergencies, 9e New York,

This week we discuss the rare but life-threatening methemoglobinemia with a focus on recognition and use of the antidote. https://media.blubrry.com/coreem/content.blubrry.com/coreem/Episode_97_0_Final_Cut.m4a Download 2 Comments Tags: Methemoglobin, Toxicology Show Notes Take Home Points MetHb –emia occurs as a results of various medications including amyl nitrite, dapsone, nitroprusside, phenazopyridine, sodium nitrite and topical anesthetics like benzocaine Patients will present with cyanosis, short of breath, fatigue, dizziness, weakness and ultimately CNS depression and death at higher concentrations. If you have a cyanotic/hypoxic patient that does not respond to supplemental oxygen, be concerned for MetHb and send a co-oximetry panel. If the level is 25% or the patient is symptomatic, you will treat with the antidote methylene blue given as a bolus of 1-2 mg/kg over 5 minutes And as always, make sure to call your local poison center to get your toxicologists involved. They can help with dosing, and they are also an important player of the public health component in cases such as these, to make sure this is an isolated incident and we don’t have a repeat of the 11 blue men situation. Price DP. Chapter 127. Methemoglobin Inducers. In: Nelson LS, Lewin NA, Howland M, Hoffman RS, Goldfrank LR, Flomenbaum NE. eds. Goldfrank’s Toxicologic Emergencies, 9e New York, NY: McGraw-Hill; 2011.