Podcasts about Methylene

Do you feel exhausted but can't seem to wind down? That wired-but-tired feeling so many women experience in midlife has a name, and a cause most doctors never address. In this episode of The Art of Living Well Podcast®, Marnie and Stephanie are joined by Dr. Scott Sherr, a board-certified internal medicine physician and expert in health optimization, to explore the connection between chronic stress, hormone changes, and mitochondrial dysfunction. Dr. Scott introduces the concept of the "sympathetic spiral of doom" — the cycle of stress, poor sleep, and cellular energy breakdown that keeps so many women stuck, and shares practical, science-backed ways to break it. The conversation covers methylene blue (what it is, how it works, and who should use it), GABA and nervous system support, and hyperbaric oxygen therapy. Dr. Scott also explains why only 6% of US adults have optimally functioning mitochondria, and what the other 94% can do about it. Key Takeaways: Chronic stress and hormone fluctuations directly impair mitochondrial function Estrogen is a critical mitochondrial optimizer, losing it in perimenopause has real cellular consequences Only 6% of US adults are metabolically healthy; symptoms of the rest range from brain fog to poor sleep to slow recovery Methylene blue supports mitochondrial energy production and works as a bridge while you optimize your health more broadly If a GABA supplement works for you, that's a warning sign worth paying attention to Down-regulating the nervous system too fast, without mitochondrial support, can cause a crash Hyperbaric oxygen therapy is most effective once you have a foundational health plan in place Sleep is one of the most powerful levers for mitochondrial health 00:00 – Introduction and Dr. Scott's background 04:13 – Why midlife women's bodies stop responding the way they used to 07:32 – Progesterone, GABA, and sleep disruption 09:04 – What mitochondria actually do and why they matter 13:16 – The 6% metabolic health statistic 17:00 – The sympathetic spiral of doom, explained 21:01 – Cortisol: misunderstood and mismanaged 29:32 – What methylene blue is and how to use it 33:55 – Who should not take methylene blue 38:33 – Performance, travel, and targeted use 47:17 – GABA support and down-regulating the nervous system 55:18 – Hyperbaric oxygen therapy: benefits, timing, and protocols 01:00:52 – One action to take today 01:03:09 – Where to find Dr. Scott and his products Guest Links: Dr. Scott Sherr: drscottsherr.com Troscriptions: troscriptions.com Use code LIVINGWELL for 10% off Products mentioned: Just Blue, Blue Cannatine, Tro Calm, Tro Zzz This episode is brought to you by Good Health Saunas. Visit goodhealthsaunas.com and mention The Art of Living Well Podcast® for exclusive pricing. Ready for a Reset, On Your Own Time? If you've been feeling sluggish, bloated, inflamed, foggy, or just not like yourself, our Vitality Reboot Anytime is a simple way to give your body the reset it's been craving. This is our do-it-yourself version of The Art of Living Well Podcast® community detox, designed so you can move through the program whenever it works best for you. You'll receive everything you need to support your body with nourishing foods, targeted detox support, and simple daily practices that help you feel lighter, clearer, and more energized. Subscribe to our Substack for wellness tips, episode updates, and your free Midlife Travel Resilience Checklist: theartoflivingwell.substack.com Follow us: Instagram: @theartofliving_well YouTube: @theartoflivingwellpodcast LinkedIn: The Art of Living Well Podcast TikTok: @theartoflivingwel Spotify and Apple Podcasts Connect with your hosts: theartoflivingwell.us/about-us

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Most antioxidants quit after one job. Methylene blue doesn't, and that's the pitch Young Goose founder Amitay Eshel makes in this conversation about where longevity skincare is actually headed. Eshel walks through why his brand maps every product to the 12 hallmarks of skin aging instead of building around a single molecule, the way he says most companies do when they're built to raise money and sell. The bigger reveal is about personalization. Eshel argues that truly custom skincare formulas are a marketing ploy, since FDA rules require formulas to be incubated and tested before they can be sold. The real personalization, he says, is the protocol, not the bottle, which matters for people in overcast climates like Washington who skip sunscreen and assume they're fine. This interview covers Young Goose, biohacking and longevity skincare, methylene blue, copper peptides, exosomes, FDA regulation versus European marketing rules, and how your skin responds to your geolocation. Eshel also breaks down entry points into the brand, from the blue peptide spray he calls the first clinical strength methylene blue product on the market to the higher-end Vampire Exosomes at $285. 0:00 How Young Goose is different in a saturated market 2:18 Regional skin health and the Washington sunscreen problem 4:18 The truth about "personalized" skincare 5:15 US vs Europe on regulation and marketing 6:39 Where to start with the brand 7:18 What methylene blue actually does Like and subscribe for conversations the rest of the media won't bother to have. #Skincare #Longevity #Biohacking #MethyleneBlue #YoungGoose #AntiAging #JasonRantz #Wellness

Hair loss has many drivers — oxidative stress, aging, medication side effects, and disrupted stem cell signaling among them. A 2026 study published in Aging examined whether methylene blue, a century-old FDA-approved compound, could address several of these simultaneously at the follicle stem cell level.Researchers found methylene blue reduced reactive oxygen species in hair follicle stem cells, activated the Wnt/β-catenin signaling pathway critical for hair regeneration, and accelerated wound closure in follicle cultures. Combined with minoxidil, the two compounds synergistically enhanced stem cell signaling beyond what either achieved alone. The compound also preserved hair follicle stem cell viability under metabolic stress conditions that otherwise caused significant cell death.One notable finding: combining methylene blue with vitamins A or C reduced its regenerative signaling effect — suggesting antioxidant combinations require careful consideration.This was an in vitro study. In vivo and clinical validation are needed before recommendations can be made.

In this episode of the Neuroveda Podcast for Complex Health, Gillian Ehrlich sits down with returning guest Dr. Dawn Ibsen, compounding pharmacist and passionate advocate for personalized medicine. Together they unpack the science, history, and growing interest around methylene blue — from its origins as a treatment for malaria to its modern use in brain health, mitochondrial support, longevity, and biohacking.They also dive into the rapidly changing world of compounding pharmacies, including concerns surrounding compounded thyroid medications, the evolving landscape of peptide access, and the balance between innovation, safety, and patient care. This conversation explores what happens when cutting-edge medicine meets regulation and why personalized treatment still matters.Topics include:• Methylene blue safety, dosing, and mechanisms• Mitochondrial health and energy production• Compounding pharmacy quality and patient advocacy• Thyroid medication changes• Peptide regulation and current challenges• The future of personalized medicineBio: Dr. Dawn Ipsen, PharmD, FAPC, FACVP, FACA is a compounding pharmacist with more than 25-years of experience serving human and veterinary patients. She is the owner of two community-based compounding pharmacies in Washington state and is recognized for her expertise in personalized medication therapy, quality compounding practices, and patient-centered care.Dr. Ipsen holds an APC Fellowship and is also a Fellow of the American College of Veterinary Pharmacists and American College of Apothecaries, reflecting her advanced training and leadership in both human and veterinary compounding. In addition, she is a clinical instructor for the University of Washington School of Pharmacy and an affiliate faculty member for Bastyr University. Her professional focus includes women's health, hormone therapy, low-dose naltrexone, dermatology compounding, and complex veterinary medication solutions for small animals, exotic pets, and large animal patients.Dr. Ipsen is deeply engaged in pharmacy advocacy, education, and legislative efforts to protect patient access to compounded medications. She currently holds an APC Board of Directors position and is the founding chair for the WA State Pharmacy Association (WSPA) - Compounding Special Interest Group. The WSPA awarded her with the Distinguished Leadership Award in 2023 and the UW School of Pharmacy Distinguished Alumni Award in 2021. Dr. Ipsen regularly collaborates with prescribers, healthcare professionals, and educators to improve the therapeutic outcomes, health, education and vitality of the communities we serve.

BUFFALO, NY — May 19, 2026 — A new #research paper was #published in Volume 18 of Aging-US on May 5, 2026, titled “Methylene blue protects hair follicle stem cells from oxidative and metabolic stress to enhance hair regeneration.” The study was led by first author Kavitha Sadashivaiah and corresponding author Kan Cao from the Department of Cell Biology and Molecular Genetics at the University of Maryland, College Park. In this study, the authors investigated how methylene blue (MB), a long-established mitochondrial-targeted antioxidant, affects human hair follicle stem cells (HFSCs) under conditions of oxidative and metabolic stress. Hair follicle stem cells are essential for maintaining hair growth and regeneration, but aging, ultraviolet radiation, oxidative stress, and metabolic dysfunction can impair their regenerative capacity and contribute to hair thinning and scalp aging. Using cultured human HFSCs, the researchers found that methylene blue significantly enhanced stem cell proliferation and viability while reducing intracellular reactive oxygen species (ROS). Importantly, MB also increased activation of β-catenin signaling, a central pathway involved in hair follicle regeneration, stem cell maintenance, and wound repair. Functional scratch-assay experiments further demonstrated that MB accelerated wound closure and regenerative activity in HFSC cultures. The study also explored how methylene blue interacts with other compounds commonly associated with scalp or hair health. While antioxidant vitamins A and C improved oxidative stress scavenging, they unexpectedly reduced MB-induced β-catenin activation when used in combination. In contrast, minoxidil—the widely used hair growth stimulant—worked synergistically with MB to further enhance β-catenin signaling and improve HFSC viability. “Overall, these findings identify methylene blue as a multifunctional therapeutic candidate that reduces oxidative and metabolic stress while supporting HFSC–mediated hair regeneration.” Another major focus of the paper involved glucagon-like peptide-1 receptor agonists (GLP-1 RAs), medications increasingly used for diabetes and weight management. Recent clinical observations have suggested that some patients receiving GLP-1 RA therapy may experience hair thinning or hair loss. The authors demonstrated that increasing GLP-1 RA concentrations caused dose-dependent reductions in HFSC viability in vitro. However, pretreatment with methylene blue substantially protected the stem cells from GLP-1 RA–associated metabolic stress and premature cell death. Beyond stem cell protection, the paper discusses methylene blue's broader potential role in scalp health. Because MB absorbs ultraviolet radiation and has previously demonstrated protective effects against UV-induced DNA damage in skin cells, the authors propose that it may help shield the scalp microenvironment from oxidative injury while supporting regenerative signaling pathways important for hair maintenance. The study also highlights MB's possible antimicrobial properties and its potential influence on scalp microbiome balance. Importantly, the authors emphasize that the findings are based on in vitro cellular models and that further in vivo studies will be necessary before clinical applications can be established. Additional research will be required to define appropriate dosing, pharmacokinetics, long-term safety, and therapeutic efficacy in living systems. Overall, this study identifies methylene blue as a potentially multifunctional therapeutic candidate for supporting hair follicle stem cell health under conditions of oxidative, metabolic, and pharmacologic stress. By combining antioxidant activity with activation of regenerative β-catenin signaling, MB may represent a promising future strategy for protecting scalp health, enhancing hair regeneration, and improving the resilience of aging hair follicle stem cells. DOI - https://doi.org/10.18632/aging.206376

Photobiomodulation Stroke Recovery: How Laser Therapy Is Restarting Damaged Brains After Stroke For seven years, a woman lived unable to remember faces. She had developed prosopagnosia, a condition that turned every person she met into a stranger, no matter how many times they had been introduced. She kept notes. She took photographs. She built systems to compensate for what her brain could no longer do on its own. Then she sat down for a single laser therapy session with Dr. Robert Hedaya. One session later, the problem was gone. “I can remember the face of the person I worked with this morning and his wife and the dimple on his face,” she told him, describing something she hadn’t been able to do in nearly a decade. What Dr. Hedaya witnessed that day and what he now works to replicate for stroke survivors, people living with aphasia, early dementia, and Parkinson’s, is the result of a therapy called photobiomodulation. And the principle behind it may fundamentally change how you understand your own recovery ceiling. Your Neurons May Not Be Dead. They May Just Be Stuck When a stroke occurs, conventional medicine draws a clear line. Tissue that is destroyed is gone. Deficits that persist beyond the early recovery window are considered permanent. Survivors are told, sometimes gently, sometimes bluntly, that they have plateaued. Dr. Hedaya challenges that directly. In his clinical experience, there is often a population of neurons that survived the stroke intact but are no longer functioning. They are alive. Their cellular architecture is preserved. But they have lost their energy supply, specifically, the ability to produce ATP, the molecule that powers every cellular process in the body. Without energy, these neurons go quiet. They stop firing. From the outside, this looks like permanent damage. But it isn’t. It is dormancy. This mirrors the concept of the chronic penumbra explored in hyperbaric oxygen therapy research, where viable tissue sits in a suspended state, waiting for conditions to change. Dr. Hedaya’s approach is different in method but identical in premise: the brain has not finished recovering. It is waiting for the right signal. Photobiomodulation provides that signal. What Photobiomodulation Actually Does “After the first laser treatment, the problem was gone. Gone. She told me — I can remember the face of the person I worked with this morning.” — Dr. Robert Hedaya Photobiomodulation, also called transcranial laser therapy, delivers precise wavelengths of near-infrared light to targeted areas of the scalp. The photons penetrate through the skull, meninges, and tissue to reach dormant neurons, where they act on the fourth complex of the mitochondrial electron transport chain, the site where nitric oxide accumulates and blocks ATP production. The photons dislodge that nitric oxide. The mitochondria resume normal energy output. The neuron now has what it needs to resume its function. The downstream effects are significant: new synapses form through a process called synaptogenesis, brain-derived neurotrophic factor (BDNF) is produced, inflammation decreases, and misfolded proteins associated with cognitive decline begin to clear. Given energy, the brain begins repairing itself, not because the laser forces it to, but because the cells already know what to do. They were just waiting for the fuel. How QEEG Makes It Precise Not every stroke survivor responds to the same laser parameters or needs treatment in the same regions. This is where Dr. Hedaya’s approach clearly separates from consumer LED helmets or generic light therapy devices. Before any laser is applied, he conducts a quantitative EEG, a brain mapping process that measures electrical activity at 19 points across the scalp. Unlike a standard EEG, which relies on a clinician reading scrolling waveforms visually, QEEG uses AI to analyse thousands of data points and reverse-engineer the source. The result is a functional map: which networks are underperforming, which are overactive, and where pathways between regions have broken down. This is paired with a neuroquant MRI that measures 30 to 40 distinct brain structures volumetrically. Together, they function as a GPS triangulating exactly where the laser should be directed, at what wavelength, power, pulse frequency, and joule delivery for each individual patient. These parameters are adjusted as the patient responds, session by session. This level of precision is what distinguishes clinical photobiomodulation from anything available over the counter. A half-watt LED helmet delivering diffuse light through hair and scalp is not the same intervention. Depression After Stroke – And the Whole-Body Connection Roughly 30% of stroke survivors experience depression in the aftermath. This is not simply an emotional response to a difficult event – it is a physiological outcome with identifiable drivers that conventional psychiatry often does not investigate. Dr. Hedaya’s model, which he calls whole psychiatry, treats post-stroke depression as a downstream expression of broader disruption: hypothyroidism, hormonal imbalance, B12 deficiency, elevated mercury from dietary sources, gut dysbiosis, chronic inflammation, and unresolved neurological stress all play measurable roles. In one of his current stroke cases, treating low thyroid function triggered seizure sensitivity because post-stroke tissue is more vulnerable to excitatory input. That kind of complexity is precisely why a comprehensive functional evaluation must precede treatment. For survivors too depleted to engage with lifestyle changes, Dr. Hedaya will now often begin with laser therapy directly. Once cellular energy is restored, the motivation and capacity to make further changes typically follow. The jump-start, he has found, enables everything else. Is Recovery Still Possible After a Plateau? If you have been told you have reached your ceiling, the core message of this episode is worth sitting with: the plateau is often not a biological fact. It is frequently the consequence of underlying conditions that haven’t been identified, and dormant tissue that hasn’t been activated. “The brain is incredibly plastic,” Dr. Hedaya says. “When you challenge it and give it everything it needs, nutrients, light, hormones, and remove the toxins, great things can happen. There is hope. There is so much hope.” His practice, the Whole Psychiatry and Brain Recovery Center, offers initial consultations via Zoom for those who cannot travel to New Jersey. For survivors with a local physician willing to collaborate, educational consultation is also available. Reach Dr. Hedaya at wholepsychiatry.com. If this episode opened something up for you, Bill’s book – The Unexpected Way That A Stroke Became The Best Thing That Happened follows the full arc of what recovery can become when you stop accepting the ceiling and start questioning it. Find it at recoveryafterstroke.com/book. If the Recovery After Stroke podcast has supported your journey, you can support the show at patreon.com/recoveryafterstroke. This blog is for informational purposes only and does not constitute medical advice. Please consult your doctor before making any changes to your health or recovery plan. The Laser That Restarts Brains – Dr. Robert Hedaya on Photobiomodulation, QEEG, and Whole Psychiatry After Stroke A laser pointed at the right spot in your brain can restart neurons that stopped working. Dr. Robert Hedaya explains how and who it can help. Hyperbaric Oxygen Therapy – Dr. Amir Hadanny Highlights: 00:00 Introduction – Photobiomodulation Stroke Recovery 01:09 Dr. Hedaya’s Medical Journey 07:55 Transition to Functional Medicine 10:31 Photobiomodulation Stroke Recovery Applications 19:21 Understanding Laser Mechanisms 24:36 Jumpstarting Healing with Laser Therapy 29:48 Understanding EEG vs. QEEG 34:10 Addressing Depression Post-Stroke 39:38 Holistic Approaches to Recovery 46:20 Patient-Centered Care and Follow-Up 51:38 The Role of Spirituality in Healing Transcript: Introduction – Photobiomodulation Stroke Recovery Dr Bob Hedaya (00:00) After the first laser treatment, the problem was gone. Gone. She told me, she said, my God, I can remember the face of the person I worked with this morning and his wife and the dimple on the face. And I said, what are you talking about? She says, have prosopagnosia. I said, says, can’t remember faces. I have to write down everything that I do and take pictures of everything and every person. I said, my God, it’s gone, gone. that’s when I went home that night and I was like, this doesn’t make any sense. How could this be? There’s nothing about a neurological condition being turned around in one minute. It makes no sense. Dr. Hedaya’s Medical Journey Bill Gasiamis (00:41) Welcome everyone to the Recovery After Stroke podcast. I’m Bill Gasiamis and my guest today is Dr. Robert Hedaya, a board-certified psychiatrist, functional medicine practitioner, and the founder of the Hull Psychiatry and Brain Recovery Center in New Jersey. Dr. Hedaya trained at Georgetown and the National Institute of Mental Health. And over the course of his career, he moved from conventional psychopharmacology into functional medicine after discovering of what was driving his patient’s symptoms had nothing to do with their medications and everything to do with their biology. In more recent years, Dr. Hedaya has added a tool that very few practitioners anywhere in the world are using, QEEG, guided transcranial photobiomodulation. That’s laser therapy, precisely using a functional brain map to reactivate neurons that survived the stroke but stopped working. In this conversation, we get into the science behind photobiomodulation and what it actually does inside the cell. How QEEG brain mapping removes the guesswork from treatment, why post-stroke depression is so often mismanaged, the role of nutrition, hormones, and toxin load in recovery. and why Dr. Hedaya believes the plateau most survivors are told about is not the biological sealing they’ve been led to believe it is. Now, before we get into this episode, if you found this podcast helpful in your recovery, my book, The Unexpected Way That a Stroke Became the Best Thing That Happened goes deeper into the tools and mindset shifts that support long-term recovery and personal transformation. You can find it at recoveryafterstroke.com/book. And if this show has supported you, you can support it at patreon.com/recoveryafterstroke. Now let’s get into it. Bill Gasiamis (02:38) Dr. Hedaya. Welcome to the podcast. Dr Bob Hedaya (02:41) Thank you. Pleasure to be here. Bill Gasiamis (02:43) It is a very good pleasure to have you here as well. The reason being is because I, what we’re going to discuss, but B the way that you came to be on my podcast was through somebody who listens to my podcast, reaching out and saying, need to have this gentleman on your podcast. And I get that a lot. And sometimes it’s like, thank you for the referral, but maybe that’s not for me, but this is definitely for me. Can you give me a little bit of. Dr Bob Hedaya (03:01) Mm-hmm. Mm-hmm. Bill Gasiamis (03:13) background for people who are listening to understand how it is that you and I came to be on the podcast today, but more importantly, like your medical journey to today. Dr Bob Hedaya (03:26) Well, so first of all, I ⁓ was treating a woman who was, let’s say, about 50 years old. She had several strokes. And her husband looked me up, and they came here for treatment. in New Jersey. And ⁓ she had significant improvement in her ability to speak over a short period of time. That’s a little. kind of summary of the situation, but it was ⁓ profound. She still has work to do, a lot of work to do, but she’s doing it and she’s progressing nicely. So that’s, he basically, I guess, decided this needs to get out. And so he contacted you, et cetera, et cetera. In terms of my journey, ⁓ that could take a few hours. So let me try and summarize it. I will say I basically went to medical school, took off six months to study medicine on my own after two years because I really, lot of reasons, but one of them was I just was memorizing things and I didn’t really understand what I was doing. And so I took off six months and I really learned about the human body. I studied, I had a schedule, a very fixed schedule, about 10 hours a day of studying and exercise and eat. was very, you know, I was young and regimented. And I had six books, six subjects that I wanted to get through and I did. And I learned all about the body and different parts of the body, how they interact with each other. And also I was able to understand and predict even certain kinds of processes and problems in the body. So that was an integrative experience, which ⁓ later really served as the foundation for what I do. Fast forward, I was going to be a surgeon, decided to be a psychiatrist instead, because I was fascinated by by the human mind. And what happened was I was trained at Georgetown National Institute of Mental Health in Washington, DC. And then I was in practice for about a year. And I was treating a woman who had panic attacks. And they weren’t getting better after a year. And panic attacks are pretty easy to treat. And so I was like, what’s going on here? She paged me one night after a year, Saturday night. And I remember I had a little beeper, you know, and I went to find a phone booth and, hey, Joanne, what’s going on? It’s midnight, right? She’s talking to me, I’m having a panic attack. And I mean, I still remember the anguish in her voice. You know, it was really, really, really rough to listen to. So Monday morning, I went into the office very early and I’m like, I’m missing something. What am I missing? So I found I had one piece of blood work. had a blood count and the size of her red blood cells was large. and I had seen that and didn’t know what it meant and ignored it. Very little. It wasn’t very large. It was just a little bit out of the norm. And I was trained in hospitals. know, in hospitals, you don’t worry about the little things. You worry about the train wrecks, right? So you never really learn what the little things mean. So here was a so-called little thing and it was ruining her life. Meanwhile, I did some research. It was a B12 deficiency. I gave her B12 injection. And with the first injection, her panic was gone. Transition to Functional Medicine I mean, gone, gone, gone. And I was like, whoa, what else am I missing? Because psychiatry, neuropsychiatry, it’s a revolving door. You go to this doctor, you take these meds, you do this therapy. That works for a while, then you go somewhere else. I figured I’m missing a lot of stuff. And basically, ended up learning. I didn’t know it was called functional medicine, but I ended up learning functional medicine on my own. Wrote a book, got introduced. to Jeff Bland at IFM. contacted me and took formal training and then, you know, that was what I was doing. And I did that, ⁓ put out a second book ⁓ and that was a best seller. And ⁓ the book was called the Anti-Depressant Survival Program. But really it was functional medicine psychiatry or whole psychiatry, which I like to call it. But it’s functional medicine psychiatry, but the publisher wanted… you know, a nice fancy title that would, know, so they decided to call it the Anti-Depressant Program, you know, survival program. Anyway, the best seller and we had thousands of phone calls, we had a lot of publicity and I couldn’t obviously see everybody. So I picked people who had treatment resistant depression and people who had the resources and the motivation or the support to be able to do what they needed to do. And I just treated them with functional medicine. And at this time, you’ve got to realize I was a psychopharmacologist. I was also trained as a psychopharmacologist. So I was doing a lot of psychopharmacology. I mean, a lot. And now I’m doing functional medicine on everybody. And after about three years, I’m noticing that I’m not actually doing that much psychopharmacology anymore. And everybody’s getting better. And the diabetes is going away. and osteoporosis is going away and one woman’s MS lesion in her brain went away and I’m like, what’s going on here? You know what? I might be lying to myself. So maybe I’m paying attention to the positive cases and I’m ignoring the negative. So I hired a statistician to go over all my cases over the course of this period of time, it two or three years. Ended up in 23 cases of treatment resistant depression. ⁓ I wasn’t lying to myself. Every single person went into recovery, not partial remission, not 50 % better, fully recovered by 10 months, every single one. And I was just blown away that, you know, I mean, I was blown away before, but then it was like, well, you’re not really lying to yourself. So that’s what I was doing until 2014 when I retired. I had actually an inaccurate diagnosis. I retired and… turned out it was incorrect. So it was actually really good to be retired, although I missed it terribly, really missed medicine terribly. But it gave me some time. And this is where this kind of starts to relate more to your audience. ⁓ I’m sitting on a hammock for six hours reading a book. Well, you can’t do that when you’re in practice. Bill Gasiamis (10:07) Good thing to do. Yeah. Photobiomodulation Stroke Recovery Applications Dr Bob Hedaya (10:13) That doesn’t happen. So but I was you know in retirement, so I’m reading this book and put two and two together over the course of time and I learned about laser which which they were using in Russia in 1980s and learned how the laser worked and And I was like whoa this could really help the brain and Then I was thinking now. I’m not in practice right, but I’m then I’m thinking but how would I know where to? point the laser in the brain for a patient. And then I keep reading in the book, and then they start talking about in the next chapter about quantitative EEG. And I’m like, oh, that’s how I would know. So I spent the next three years or so actually studying these methodologies. And then in 2017, I want to say, or 2018, I treated my first patient who had early dementia. published this case actually. I was treating her for early dementia. And I had treated her for six months with functional medicine, know, hormones and treating infections, et cetera, et cetera. And she really was much better. And then I was ready to do my first quantitative EEG. And she’s doing much better. She still has some symptoms. And I do the QEG. And actually, if I could share my I don’t know if I can, Okay, so basically what I just sent you is ⁓ how her brain looked after six months of functional medicine, right? So I was shocked because I thought her brain would look much better. And then I said, okay, let’s do the laser. So I knew where to point it because the QEG and this was the shocker. With the first laser, she had a problem. before the laser treatment of facial blindness. I don’t know if you know what that is. It’s people who can’t remember faces. They just met someone, they can’t remember the face. It’s called prosopagnosia. She had acquired it seven years earlier. Bill Gasiamis (12:11) I do. Yeah. Dr Bob Hedaya (12:21) After the first laser treatment, the problem was gone. Gone. She told me, she said, my God, I can remember the face of the person I worked with this morning and his wife and the dimple on the face. And I said, what are you talking about? She says, have prosopagnosia. I said, what? What is proto-diagnosia? I don’t know what that is. She says, can’t remember faces. I have to write down everything that I do and take pictures of everything and every person. I said, my God, it’s gone, gone. that’s when I went home that night and I was like, this doesn’t make any sense. How could this be? There’s nothing about a neurological condition being turned around in one minute. It makes no sense. But then I realized, I reasoned it out, realized, well, she had a population of neurons that were kind of alive, but they were not really functioning. And then I kind of jump started them with the laser and they went about their business and did their job. Bill Gasiamis (13:19) I love it. So, that’s a contrast on what you’re doing as in psychiatry, because psychiatry from, you know, my understanding is, you know, if you, if you speak to somebody who’s been through psychiatry and you ask them, how’s your condition or how is your situation or what has improved, very few people can say, ⁓ well, I’m, I’m better. I’ve overcome it. We’ve moved beyond the resolve that Dr Bob Hedaya (13:27) Yeah. Bill Gasiamis (13:47) Nobody really does that. They kind of just continue to go through the motions of another appointment, another medication, another adjustment in the amount of medication, et cetera. And what you said also seems a little bit ridiculous and kind of too quick. How do you get that kind of a solution that’s meant to take ages? You’re supposed to go through the typical times and it’s supposed to be costly and Dr Bob Hedaya (14:06) Too quick. Bill Gasiamis (14:16) unattainable and all these things. And it makes people feel sometimes I know stroke survivors who come across promises like that from other ⁓ people who talk about ⁓ perhaps ⁓ non-studied, ⁓ no scientific background kind of solutions to stroke and then kind of give everyone a blanket. If we do this, we’ll fix your stroke deficits, which is not true. ⁓ And then And then it leaves people feeling like they got ripped off. If they paid money, it leaves people lost for hope that there is no hope, cetera. And we kind of find ourselves in a, okay, desperate, what do we do now situation, right? And that’s kind of why I got excited when your patient’s husband reached out and said that we should chat. And I had a bit of a look into the kind of work that you do. ⁓ Functional medicine, I’ve heard about heaps. Dr Bob Hedaya (15:00) Hmm. Bill Gasiamis (15:14) And I love that it’s merged with psychiatry because when I started my journey in 2012, overcoming the first brain bladed and the second brain blade six weeks later, I went into functional medicine study to find out not formally, but I started doing what I didn’t know at the time was studying functional medicine and understanding like how I can decrease the inflammation in my brain. and provide the right environment for healing. And the first thing I came across was a book by somebody that you’re gonna know, Mark Hyman. And the book was, ⁓ the book was, ⁓ Eight Fat Get Thin. I read it, not wanting to get thin, I read it ⁓ because it ticked the boxes for the diet that I was gonna use to reduce inflammation in my brain. Dr Bob Hedaya (15:54) Okay. Bill Gasiamis (16:12) And the side effect was I thin. I wasn’t going for that because I was taking medication. was taking ⁓ dexamethasone, which made me put on weight and made these like all these types of ⁓ terrible side effects, but it was helping reduce the inflammation in my brain. So I, I was happy to have it, but I needed to achieve the same outcome as dexamethasone. Dr Bob Hedaya (16:13) I’m kidding. Bill Gasiamis (16:41) or a similar outcome as dexamethasone on a permanent basis without taking dexamethasone to improve the situation in my brain. And then I started to realize that I had a lot of power and I was ⁓ only not guided properly because my physicians, my doctors weren’t able to offer advice in that space. And had I not been the curious kind of guy that I was, I never would have come across Dr. Hyman and some other amazing guys who wrote books at around about that time that were similar in nature. so you’re, and then, and then a little while later, I found there was a Tasmanian, ⁓ psychiatrist, forget her name, but I have her book on my shelf upstairs who wrote a book about, ⁓ psychiatry and food and, the link between food and a good psychiatric outcome. Dr Bob Hedaya (17:15) huh. Bill Gasiamis (17:39) in the brain. And I just thought, okay, there’s much, much more that needs to happen here. Now, this the connections, there’s a lot of connections here. So recently on my YouTube channel, somebody left a comment I wanted to know about red light therapy, and will it help their brain? And I’m like, I have no idea. But let me do some research. I went on to PubMed, I found some articles and wouldn’t you believe it, there is a whole bunch of ⁓ proper data that Dr Bob Hedaya (17:40) You know what? Come on. Bill Gasiamis (18:08) suggests that there is a benefit. The only challenge that I always have with all of these potentially beneficial interventions is there’s no diagnosis done in the first place to determine whether somebody actually is eligible for a particular intervention. And what it sounds like you’re able to do is the diagnostics part and determine their eligibility. Tell me a little bit about why that is important. Dr Bob Hedaya (18:35) Right. Okay, so let me back, I wanna back up, because you said something very important, then I wanna reiterate it. I just gave you before a case of a woman who in five minutes, her problem was gone, right? Not, people should not think that’s the norm, okay? Not the norm. Occasionally it happens, I have a guy who had a head injury and had light sensitivity and confusion in certain situations with light, and one treatment, boom, gone. Understanding Laser Mechanisms People, you know, I have cases like that, but most of the time this is a gradual process. So people should not think it’s a cure-all for everybody. We do have to know who it’s good for. So what we do diagnostically before we do this is I will look at their brain, you know, obviously take some history and all of that business, but we do a quantitative neuroquant MRI. So we look at the different structures inside the brain. You know, we look at… Bill Gasiamis (19:32) Lovely. Dr Bob Hedaya (19:32) 30, 40 different structures. And then we also do a quantitative EEG, which is an electroencephalogram. We measure the electricity in the brain in 19 different places. And then there’s this really AI that takes all this data and it reverse engineers it. It’s called the inverse solution. And you can actually see the pathways, all of the pathways in the brain and the surface areas of the brain. And you can look at that, correlate that with the person’s symptoms. with the neuroquant MRI, it’s like a GPS, right? A triangulation of information and then assuming there’s not a mass or an aneurysm or some reason not to do the laser like an overactive brain or something like that, then we could consider using the laser. And then we also know where we want to do it based on the symptoms, based on the QEG, based on the neuroquant. We will decide what we’re going to target. And then we combine that, sometimes, not always. Bill Gasiamis (20:05) Hmm. Dr Bob Hedaya (20:31) with neurofeedback so we can exercise the areas that we want to exercise or calm down the areas that we want to calm down. And sometimes with hyperbaric oxygen, things like that. And hormones, using hormones or things like that. Bill Gasiamis (20:42) Yep. Hyperbaric oxygen has been a topic that I’ve discussed as well on the podcast and the people that I spoke to about hyperbaric oxygen and guys, I can’t remember right now, but I’ll put a link in the show notes for anyone listening so that you can go and find that episode and have a listen to it. Basically, what I loved about their approach was that they did a massive amount of diagnosis beforehand to determine where the penumbras were and then target those penumbras while the person was in the chamber. by getting them to do certain exercises that would activate those areas and therefore be targeted. So it sounds like the laser therapy is similar. Tell me about the laser. What kind of a laser is it? How does it get targeted to a specific spot? And what does it do when it goes there? I mean, I imagine it just doesn’t point there and go, I’ll illuminate that and it’ll be better. How does it actually work? Dr Bob Hedaya (21:18) Mm-hmm. Mm-hmm. Okay, so the laser, there are a bunch of different parameters that we have to adjust for each person. So it’s the frequency, how fast is the wavelength? What’s the wavelength? How many times per second is it pulsed? 10 times per second, 40 times per second, 50 times per second. Is it a 8, 10 nanometer wavelength or is it a 1064 wavelength? How many joules are we delivering? you know, where are we delivering it? So there are lots and lots of parameters to adjust, right? ⁓ What does it do? So simple, the first thing that it does, it does many, many things, right? But the very, very first thing it does is it actually releases ATP, the energy molecule, from your mitochondria. So it basically, the photon goes to the fourth channel, the fourth complex in the mitochondria, bumps off the nitric oxide, and that opens the flow of ATP. Well, if your brain, if your neurons have energy, they say, ⁓ energy, ⁓ well, we know what to do with energy. Let’s fix the puddles. Let’s build the roads. Let’s make the connections. Let’s do whatever we got to do. So now you’re getting energy flow. You also get synaptogenesis. You build new synapses. You get production of brain-derived neurotrophic factor. Bill Gasiamis (23:01) Wow. Dr Bob Hedaya (23:05) You get reduction of inflammation, get reduction of tau proteins and misfolded proteins. ⁓ You get, subjectively, get cognitive enhancement. aphasia, you know, people can start to speak. I mean, I can tell you one story. We used to shave people before doing the laser because I wanted to… Remember, you got a skull, you got the skin, you got all this stuff, right? How are you going to get the light into the brain, right? So we know that only about Bill Gasiamis (23:31) Mmm. Dr Bob Hedaya (23:35) 2.6 % of the light goes through the skull and the meninges and all the layers, right? So we used to shave people because I want to get the hair out of the way, right? At least get rid of some of it. So I had this woman who came to me, this is probably seven years ago, I guess. And at that time, I would not use the laser until I had done functional medicine on the patient. Because I figured, you know, let’s get the terrain straight. the nutrients, the hormones, get rid of the infections, get rid of the toxins, then we’ll apply the sunlight to the brain, to the plant, right? That was my logic. I thought that made perfect sense. So this woman came to me. She was 70 years old, obese. The husband wanted me to give her the laser. She wouldn’t change her diet, not an iota. High blood pressure, obesity. She could not speak. She would not take a medicine. She would not… Bill Gasiamis (24:04) Mm-hmm. Mm. Jumpstarting Healing with Laser Therapy Dr Bob Hedaya (24:33) Like, you name it, non-compliant all the way. Maybe you could say a word or two, that was it. Her husband begged me. I said, listen, it’s a waste, okay? It’s just a waste. I can’t ask her to shave her head. It’s not gonna work. I’m not doing it. He did not stop. So finally, I said, okay, fine, I’ll do it. So I was in my office and I’m making the laser plan. And I’m just writing, and something pops out of my mouth, God, I need a miracle. So I go into the laser room, and I start doing the laser. She starts talking. I have tears. He has tears. She starts talking. So by the end of like 20 sessions, I’m sitting with her having a 45-minute therapy session, because it turns out she was really severely abused when she was young. ⁓ She’s having a whole conversation with me. Turns out she’s psychotic also now. She’s also a psychotic and we didn’t know. So she needs to take some medicine for the psychosis because in the middle of the night, she’s going around with a baseball bat and she wants to like do, and she wouldn’t take medicines, I had to stop the laser. But that was an amazing thing because that was one, but with aphasia, typically it’s more gradual, much more gradual. But I have had a couple of patients where, and a woman came from Chicago and she just started talking also. So everyone’s different. You can’t necessarily come into this expecting that kind of thing is wonderful when it happens, but you Bill Gasiamis (26:14) Yeah. I love the fact that you can intervene with a laser, but also people can intervene with all the things that you said that that patient wasn’t doing beforehand. And that you that’s the top of the hierarchy of how you approach healing the brain is you do all those things. And then you supplement with ⁓ with a therapy like laser or whatever. And you kind of combine that and you make Dr Bob Hedaya (26:25) Yeah, yeah, you got it. Bill Gasiamis (26:42) like the, you make a soup of amazing things that all come together at the same time to support you together. And laser is just one of those things, but all the hierarchy like is so important because Dr Bob Hedaya (26:48) Yeah. It’s all important, all important. But I will tell you this. I have come to the point now where I believe that like people come to me and they don’t want to do anything and I’m like, okay, because I can jumpstart you, assuming you’re a good candidate. I can jumpstart you with the laser. I could just jumpstart you and then once I’ve jumpstarted you, say, ⁓ yeah, okay, I’ll do this. ⁓ okay, I’ll do a little of this. I’ll do a little. Because I’m bypassing everything and I’m giving you energy. Right? And so if you have energy, then, you know, there’s a lot that you can do that you couldn’t do before. So I kind of switched my model, really, only because of the accident of this guy who insisted I give his wife the laser, you know. Bill Gasiamis (27:30) Yeah. That’s not a way to go. mean, ⁓ there isn’t one way to solve a problem. there’s probably many iterations of, know, like how you can put that particular, like intervention together for a person that could specify for that individual, we’re going to go down this approach for you. You were going to go down this approach to get you going. Since you have all these, ⁓ challenges and energy is difficult. Maybe we’ll go directly with the laser and then Dr Bob Hedaya (27:46) Bye. Mm-hmm. Bill Gasiamis (28:09) We give you the skills, the energy, Dr Bob Hedaya (28:09) That’s right. That’s right. Bill Gasiamis (28:12) the training, the coaching, the support to implement the rest of the stuff that you need to implement to continue providing the right ⁓ space for your brain to heal in ongoing so you’re not just relying on laser. Dr Bob Hedaya (28:14) Yeah. ⁓ Yeah, yeah Yeah, if someone comes to me post stroke for example and the laser is appropriate I’m not gonna say well, we’ll get around to laser in six months. I’m not gonna do that They need relief they need help if it can help them Let’s do that. Let’s jump on that and you know, and then is the other stuff we need to do will do it And there’s usually stuff to do ⁓ But I want to get the healing remember the laser is healing It’s clearing out proteins, reducing inflammation, increasing blood flow, synaptogenesis, doing all these good things over the course of time. So you really want to get that process going, I feel, as soon as you can. then, okay, now you can work on the diet that’s going to take some time, check the hormones, make sure there’s no infections, toxic element, you know, all that functional medicine stuff. Maybe you need some medication for depression, you know, it’s having a… a phaser or a stroke or a head injury or some of things like this, they turn your life upside down better than I know. It’s ⁓ incomprehensible, really. Bill Gasiamis (29:26) Yeah, really. Yeah, really challenging. With a laser, how much laser for how long, how often? Understanding EEG vs. QEEG Dr Bob Hedaya (29:37) Great question. So let me say a couple of things. First of all, we have laser and then we have the LED helmets, right? You’ve read about and read the helmets, right? So there are a lot of studies on the helmets. There’s a question of whether they’re really having a direct effect because for a few reasons. Number one, it’s LED, it’s not a laser. Number two, the voltage is so low, if you’re only getting 2.6 % through and it’s so low to begin with, what do you think you’re actually delivering into the tissue? know, it’s hard to imagine that you’re delivering much. there, know, Henderson, I think, wrote an article where he showed there’s no penetration into the brain. But the studies do show cognitive benefit. So it could be an indirect effect or, you know, all the studies are done by the companies that make the… the helmet, there could be some bias. I don’t know the answer there. The laser ⁓ itself is more potent, so we’re doing, say, 30 watts. So the equivalent of a 30-watt light bulb, right? They might be doing half a watt, a very, very, very dim light bulb. We’re doing 30 watts. Now, we’re targeting the area or areas that we want to hit. Now, it goes through 2.6. Bill Gasiamis (30:34) devices. Dr Bob Hedaya (31:03) 5 % of it goes through. And then of course it’s going to be diffused, right? And it’s going to hit the surface tissues more. 1064 will penetrate deeper into the brain, but you don’t really have to go that deep because there’s downstream effects that happen, right? So we really, and then we adjust the parameters depending on how someone does. for example, you know, I had a woman who I was treating And actually it was the patient who her husband contacted you. I was treating her with a certain amount of energy and then after about five sessions I went up, I doubled the energy and boom, she had a response. But we have no way of knowing that’s what she needed. It’s all a calculation. But she, you know… Bill Gasiamis (31:39) Yes. Dr Bob Hedaya (32:00) Whatever it is, the thickness of the skull or the membranes or whatever it is, that’s what you needed and that’s what worked. Bill Gasiamis (32:06) Yeah. Tell me about ⁓ QEEG. So let’s dive deeper into it a little bit because we kind of glossed over it. I think it’s important to discuss how it’s different from EEG, ⁓ what EEG is and then what the Q adds to EEG. Dr Bob Hedaya (32:24) OK, so the EEG, imagine somebody, you put a cap on, and it has all these electrical wires that are measuring the electricity that comes, that’s on your scalp. It’s coming from your brain, but it’s measured at the scalp. And each one is measuring the energy from that spot, comparing it to other spots. And then you might, your viewers might remember. all those squiggly lines, you’ll see like 19 or 20 squiggly lines and you’re like, what is this spaghetti? I don’t know what this is. And I mean, even in medical school, we looked at it and our eyes would glaze over because who knows what it is. So the neurologists look at it and they’ll scroll through it and look for certain patterns to see is there a seizure or is there area of damage where there’s a lot of slowing like the frequency of the electricity slows down if there’s tissue damage, right? And they look visually to see what they can find. But we know with AI, you can get the patterns that you can determine. There’s no way the human mind, the human eye, a trained eye, I don’t care how long you’ve been looking at EEGs, there’s no way you can extract this data that we now extract. So the quantitative is actually looking at the quantity of this, what’s going on here versus the quantity of electricity that’s here versus what’s here versus what’s here. And then all of that is calculated and they say, ⁓ well, if this is high and this is here and this is low here and this is this, well, that means they’re coming from this deeper place here and that’s under functioning. And, you know, that’s done over thousands, thousands of points in a very short order, very short order. It’s amazing. I can’t imagine practicing without this. So now I can look at the thalamus. I can look at the putamen. Addressing Depression Post-Stroke Bill Gasiamis (34:07) Mm-hmm. Dr Bob Hedaya (34:17) In my office, I can do these tests in my office. If a patient is my patient, I can send the QEG to their home and do it in their home. And I get this imagery that’s immensely better than a spec scan. It’s not an MRI, an MRI structure. This is function. Okay, this is function. It tells us how different parts are functioning. Bill Gasiamis (34:40) What’s lighting up? What’s not lighting up? What could be lighting up better? What’s not going to light up anymore? Dr Bob Hedaya (34:45) What’s the information flow? How is the flow going from here to here? How about this network? Is this network working? Is this network overworking? Is it underworking? How about the neuron populations that are firing when I’m relaxed? How are they doing? How about the ones when I’m thinking? How about the ones when I’m thinking fast? How about the populations when I’m emotional? We can look at all those populations and see what’s going on with those populations. And then we can actually target them. train them, et cetera. And then we have that data that we treat, and then we measure and see is it getting better? Do we need to change the protocol? It’s not helping, it is helping, et cetera. Bill Gasiamis (35:29) Yeah. with stroke, so many things come from stroke that people are not equipped to handle. You know, firstly, all of the, ⁓ the parts relating to, ⁓ simply the person discovering them, they’re, they’re immortal after all, you know, you become a mere mortal immediately and you kind of work out the most terrible thing that could have happened to me happened. My brain is injured and all these things go away. Right. And then. Unfortunately, like I think it’s 30 % the studies of people who experienced stroke will then also experience depression. Like as if recovering from stroke isn’t enough and all the deficits that you also have to recover from depression. What’s it like? How can that be supported with this particular method, this approach that we’re discussing here today? Dr Bob Hedaya (36:28) So ⁓ kind of separate from stroke, ⁓ treat treatment resistant depression with laser all the time. With stroke, we use the laser, but you have to watch the QEG to make sure you’re not getting overstimulation, number one. Number two, I learned this with the patient that referred me to you, ⁓ that after, put us in touch, there was actually a central Bill Gasiamis (36:44) huh. for us in touch. Dr Bob Hedaya (36:58) hypothyroidism, meaning the low thyroid function, right? And we had to treat that, but the problem was as we treated that, there was a supersensitivity and because the tissues after stroke are more vulnerable to seizures, the patient actually had a seizure. She was actually having seizures we didn’t know, mild seizures. And then when we treated the thyroid, then we actually ended up having seizures. now we have to support, you need thyroid function to be good in order to not be depressed, right? If you have low thyroid, you’re much more likely to be depressed in the face of a stroke or other stresses. So we were kind of a little bit of a bind there because we went and treated, but it’s too sensitive. So anyway, we’re actually threading that needle nicely and we’re moving slowly and carefully and keeping, there’s no seizure activity now. But you have to treat the depression because of the depression itself. Bill Gasiamis (37:29) Yep. Dr Bob Hedaya (37:55) is a big problem because you know to recover from stroke, man, you gotta work hard. You gotta keep a good attitude. gotta have your eye on the ball. There’s no room for like… I’m going to give up. There’s no room for that. I mean, of course you feel it and I mean, it’s all natural feelings, but you have to really be determined and that’s essential. so with depression that is ⁓ really can get in the way. So we treat it. The laser can treat it. Sometimes pharmacology, sometimes therapy, sometimes yoga, know, hyperbaric, all these things that we do with the nutrition, making sure the hormones are right. All these things work together, you know. Bill Gasiamis (38:14) Yeah. I love all of those things that you mentioned. And then all of a sudden you just throw in yoga. mean, it just, it’s so counterintuitive, isn’t it? When you have a conversation about all these acronyms and all these tests and lasers and all that kind of stuff, and then you just throw in yoga casually like that. It’s, and we underplay it, but it’s such a massive thing in the picture of what creates the environment for a good recovery, but also I love that you mentioned the thyroid in that conversation as well about depression and what can also be a trigger to depression and people may have depression, never check their thyroid and not know that it’s a thing. Now I’ve had thyroid surgery, have ⁓ half of my thyroid removed because I had a massive ⁓ goiter on one side and that was such a difficult thing to discover and have to go through 16 months after brain surgery. but they only discovered it after my brain surgery when they did a chest x-ray, because I wasn’t recovering properly and they found that I had this goitre which would have been there for a long, long time impacting my health and all sorts of things. And I make that point because often people who have had a stroke and can’t speak, for example, have aphasia, ⁓ or their arm doesn’t work or the leg doesn’t work properly, will say, I just wanna fix this thing. If I could speak, Dr Bob Hedaya (39:40) No. Holistic Approaches to Recovery Bill Gasiamis (40:09) everything’s better, but they’ve never looked at the other things that may be contributing to keeping the speech at a level which is not good enough for them, for example, to be comfortable with. And it’s like this one track mind, I’ll just get my speech back, I’ll get my speech back, you what do I need to do? Or make it go, get back for me. There’s often no looking into the other things that might be causing depression, for example. Dr Bob Hedaya (40:31) Thank you. Bill Gasiamis (40:38) After stroke, know for a fact that the gut gets impacted ⁓ very dramatically from a stroke and the gut is highly linked to ⁓ mood and how you feel. And nutrition is what supports the gut to feel better and taking out things from the diet that are ⁓ making the gut sluggish and not work appropriately will ⁓ improve your mood and how you feel. It’ll make a difference and Dr Bob Hedaya (40:59) Okay. Yeah. Bill Gasiamis (41:08) and it’ll add to one of those little tools that supports depression and makes depression less impactful and you have less swings, et cetera. And that’s kind of the point that you’re making is that you don’t just turn up and do psychiatry. We’re gonna do psychiatry, treat you pharmacologically and then send you on your way and then see you in six, 12, eight months again or whatever and then just repeat the process again. It’s a whole, know, holistic is the word that you hear, but it is a broader conversation that people need to be having. And that sounds like what you guys do. It sounds like the conversation doesn’t encompass, it encompasses everything. It doesn’t just focus on one intervention. Dr Bob Hedaya (41:56) That’s why I call it whole psychiatry. But it really should be whole neuropsychiatry or whole brain or, you know, but it’s whole body, whatever you want to call it. It’s really more than the body because obviously the social connections play a big role as well, you know. So yeah, everything you’re saying is 100 % true and it’s all real. Everything you’re saying is real. Everything you do. mean, simple things going back to the B12. You you need B12 to… Bill Gasiamis (41:58) Yeah. Dr Bob Hedaya (42:26) remyelinate your neurons. need to keep the mercury, by the way, got to keep the mercury levels low. know, the mercury, if you’re eating tuna fish or swordfish and you have high mercury levels, know, the mercury will actually prevent you from making new branches. The mercury actually will bind on tubulin, which is like a brick that you need to build new roads. And it will prevent the tubulin from building new roads in your brain. So here you are working hard trying to… Bill Gasiamis (42:28) Mmm. Dr Bob Hedaya (42:54) do things and you’re a can of ⁓ whatever tuna fish with loads of mercury two, three, four times a week. Well, that’s not working, you know. So that’s why you really want to look at the whole thing. It’s a lot. It’s really a lot. You know, it’s a big program, but you you take, take steps. Everybody has different needs or not everybody has to do everything. Bill Gasiamis (43:04) Yeah. Yeah. Not everybody needs to do everything to achieve significant results, but it’d be amazing to be able to find the things and target those, the ones that you’re to get the most bang for buck on. So you’re to putting time and effort into things that are not getting results. For example, an led hat from, uh, Amazon for $9 that you put on your head. And it’s basically just a red light hat. It’s not really doing the thing, right? Dr Bob Hedaya (43:32) Hmm. Ha ha ha. Bill Gasiamis (43:49) And that’s kind of why I started to have that conversation and do a little bit of research in what they, know, what’s medically known as or scientifically known as photo bio modulation, you know, the idea is great, but then it came to me from somebody who I imagine was looking at a seven or eight or $9, $10 cap with red lights that put on the head and they Dr Bob Hedaya (44:00) Right. Bill Gasiamis (44:15) paid money for a cap and hoping for an outcome and they didn’t get an outcome and then they’re wondering why. I suggest when people are looking into those topics, is gonna go and have a look at the science, what it says about the nanometers of the type of light that you need to be experiencing, how, where, who, and always do these things with medical supervision. It really challenges me when I find out people do things like, know, methylene blue was a thing. Dr Bob Hedaya (44:44) Right. Bill Gasiamis (44:45) uh, very recently and people will just go get a bottle of Methylene blue from somewhere and just start taking it and have no idea what they’re doing and, and, and, know, what they could hope for. They could be making things worse than for themselves and actually making themselves, um, like make things a lot harder for themselves. So, uh, my point is this all needs to be done under medical supervision. Typically when you, somebody reaches out to you, how do you begin the conversation and then how does that person engage with you? And then what happens after they’re treated? Because often I know from my experience with all my neurologists, et cetera, very rarely do I see anybody a second time, six months, 12 months, 18 months, five years down the track. You usually go in, they patch you up, they send you home, you get back to your life and then maybe you do one MRI. Dr Bob Hedaya (45:36) Really? Bill Gasiamis (45:44) ⁓ for a few years after brain surgery just to make sure that everything’s stable. But that’s about it. Nobody follows up with you. Dr Bob Hedaya (45:52) No, it’s a whole different ball game with us. No. So what we do first is ⁓ if someone will contact us through the website, which is wholepsychiatry.com, they will actually fill out a form. And if we feel that it looks like we might be able to be helpful to them, then we will send them a welcome letter. And then they will have the opportunity to meet with our new patient coordinator at no charge. Patient-Centered Care and Follow-Up and she’ll talk with them for 15 to 30 minutes and kind of tell them what’s going on and see if they, you know, the fit is good, et cetera. And then they have an opportunity if they want to meet with me on Zoom for 15 to 30 minutes and ⁓ I’ll figure out, can I help them? Can I not help them? Is it a good fit, et cetera? And then if it looks like, you know, green light and they decide they want to move forward and it makes sense, then we’ll schedule an evaluation. The time duration of the evaluation depends on what kind of patient. It could be a couple of hours, could be four and a half hours. But usually for neurological patients, straightforward, it’s a shorter evaluation. And before the evaluation, we’ll collect the neuro-quant and the QEG and the old records, et cetera. And then I will go through all of that data plus lab data that we collect. And I will then have an idea. Okay, what’s going on here? Now there’s all these things. There’s digestion, there’s nutrition, there’s immune function, inflammation, toxins, hormones, all the hormones, structural issues, chiropractic issues, traumatic brain injury, cardiovascular issues, et cetera. We look at all of that and then to see what are the players here and spiritual, social resources, connectivity. We look at all of this. And then we have a whole picture of what’s going on. And then we can figure out, okay, how do we want to approach this? And sometimes we approach it very lightly. Say we just start with the laser, that’s it. Or sometimes somebody says, no, I want to really get in there and fix everything that’s wrong. Okay, well, we identified these five or six things that need correction. So let’s stage this in order. And that’s what we’ll do. And everyone’s different. And then we have follow-up depending on what we need in two weeks, in a month, six weeks, not usually six weeks. Once things are stable, it could be every two, three months or four months. But in the meantime, I’m in the boat rowing, paddling with them. That’s the way I do it. I treat people, really, I try to treat people just like I would want to be treated myself, like I would want my family to be treated. I do the very best. I love what I do, you know what I mean? I just love what I do and I try to do the best, highest quality. And it’s not that I’m perfect, not that I don’t make mistakes, ⁓ not that I know everything because that’s for sure that I don’t, but that’s my approach. So I try to be in the boat with the patient. As long as the patient’s paddling, I’m paddling just as hard, if not. Bill Gasiamis (49:02) Yeah, it sounds like at least if things, if you don’t make the right approach initially, there’s a whole bunch of tools and resources and things that you can kind of focus on. And one of the things you mentioned, again, you glossed over it, but I love that you do this is spiritual. Like it might be a spiritual journey that the person needs to take. And it’s so overlooked because people, you know, do have… Dr Bob Hedaya (49:22) yeah. yeah, yeah. Bill Gasiamis (49:30) existential crisis after a stroke. it’s like a spirituality helps somehow for a lot of people ease, heal that, ⁓ help people move through, you know, the weeds and come out into the opening and then kind of see the opportunities and where they need to go next. And people don’t need to engage with somebody like you to go on a spiritual journey. That might just be something they’ve ever looked and they can just go, you know what, I’m going to pick up the Bible or ⁓ I’m going to learn about this particular ⁓ spiritual journey or whatever and go through it and do whatever it is that they need to do to kind of start beginning the healing journey in their own special unique way. It’s really important that spirituality gets addressed and it’s not glossed over. And I’m not saying that you did or I did or we do, but in the back of the minds, stroke survivors may not consider that being important. The Role of Spirituality in Healing Dr Bob Hedaya (50:31) Yeah, first of all, I’m passionate about spirituality. I mean, passionate because the truth, in my opinion, is that consciousness, your level of awareness is really consciousness is the foundation, the substrate of everything that exists. The material is an outflow from consciousness. So I could talk about this forever. Not everyone is oriented this way. So, you know, I just saw a businessman, very successful businessman ⁓ last week. He doesn’t want to just, you know, get me back online. OK, I don’t want to hear this mumbo jumbo and I just can’t. I don’t want to delve into it. Just get me better. know. But other people are like, I want to find the meaning, you know, and it’s very important. to find the when I think generally for most people finding the meaning in it is critical. And I’ll say one thing, my mother, may she rest in peace, was in the emergency room, probably 25, 30 years ago, I don’t know, something was wrong, she was in the emergency room for seven, eight hours or whatever, and some guy comes by and says, ma’am, can I get you a sandwich? And she says, oh yeah, please, please get me a sandwich. He gets her a tuna fish sandwich, whatever it is, right? He leaves. She’s so grateful. She’s so grateful that she volunteers in the hospital for 20 years. Okay? This guy has no idea what he did and all the people that he helped through her, right? So you’re, you you and you’re not just you, but we, each of us in our small minds, we have no idea. the impact we have on other people. So if it’s important to a person to have a meaningful life, understand that you don’t have to be running a company. You can smile at a stranger, change their day. There are things that you can do and you have an impact. Now, that’s a small consolation when you’re dealing with a stroke, obviously, but that’s when you kind of want to work to a meaningful ⁓ attitude and a good attitude. So yes, the spirituality is… many people very important. Bill Gasiamis (52:54) David who brought us together ⁓ wanted me to meet you so I could interview you. that part of the role that he played in what happened to his wife ended becoming something that helped other people. Isn’t it interesting? The whole journey started on. Dr Bob Hedaya (53:15) Exactly. Bill Gasiamis (53:20) He contacted me because he wanted to make something good come of what happened to his wife, which I’m sure his wife was also interested in. And he said, you need to get Dr. Hedaya on because we need to share more information, make this stuff aware. so, and I’m like, well, that’s perfect. Of course I do. Whoever comes to me with that kind of information because they want to help other stroke survivors because he’s hoping that other caregivers that are in his shoes have a better outcome. They have more support. They have more information. They have more tools. Dr Bob Hedaya (53:27) Mm-hmm. Bill Gasiamis (53:50) That’s the spiritual journey. You don’t have to call it ⁓ Christianity, Judaism. You don’t have to call it something. You don’t have to label it, but that is what spirituality looks like in practice. Dr Bob Hedaya (53:56) Right. Right. That’s exactly it. That’s exactly it. And it gives me chills because, you know, I know his wife is suffering, you know, and ⁓ but she’s making really great headway, but it’s hard, you know. But look at look that he’s reaching out and he cares enough about other people and to and make her journey and what she’s gone through and what she’s learned be useful to other people. That’s it. That’s just beautiful. I mean, that that speaks volumes about him and her. Bill Gasiamis (54:32) It does absolutely and her and your work because your work is not unique. You’re not the only one doing this kind of work. I think there’s only kind of a small percentage of ⁓ medical professionals in the field that are practicing in this way. And hopefully that continues to grow. ⁓ If somebody wanted to, well, somebody lots of people are listening to this today. If anyone wanted to reach out ⁓ who thinks, you know, that they might be able to ⁓ benefit from or go down this kind of approach. How should they go about that? What questions should they be asking of you, et cetera? Like how do they begin? Because this is a different conversation than I have ⁓ neurological injury, have aphasia. It needs to be positioned differently, this conversation. Dr Bob Hedaya (55:29) Tell me what you mean. I’m not really clear what you’re saying. Bill Gasiamis (55:33) If somebody wants to find a clinician who practices the way that you practice, you guys, for example, you know, you know, who thinks about the brain in a different way. What, what should they be looking for and what. Dr Bob Hedaya (55:38) Aha, I see, I see. I would say that they should go to the website for the Institute for Functional Medicine. And there’s a tab. This is find the practitioner. And make sure you look for a practitioner that is certified, fully certified. And then investigate the practitioners who are in your area and see if they experience. in this area. there are not I’m not aware of, there’s a guy somewhere in the Midwest here who’s using a laser, I believe. And then maybe other people that I don’t know about using lasers, but I’m not aware of anybody that I could say, go see this person for this quantitative EEG guided transcranial photobiomodulation. I’m not saying that that is readily available. It’s not. But the whole functional medicine thing, there are a lot of practitioners. And I think that’s the way to go there. Just do your homework. Bill Gasiamis (56:48) Yeah. Yeah. Cool. Your organization is whole psychiatry and the brain recovery center. Is that right? Okay. So the psychiatry part of it, ⁓ people might be listening and going, well, that doesn’t apply to me, the specific word specifically doesn’t need to apply to an individual to engage with you because, we’re not just dealing with the psychiatry part of somebody’s recovery. Dr Bob Hedaya (56:56) Yeah. Right. Thank you. No, no, we’re dealing, we treat psychiatric, but we treat neurological. You know, I started as a psychiatrist. was, you know, certified by the American Board of Psychiatry and Neurology, but I was doing psychiatry. then, you know, just following, you know, learning and whatever, I ended up, you know, doing some neurology here. And so, but we didn’t change the name to the whole neuropsychiatry and brain recovery. Maybe we should, or maybe the whole brain recovery center or something like that. So, you we do both, no, and if, and if, I can’t be helpful, of course, I’m going to tell people this, we really don’t want to waste people’s time, energy, money, et cetera. ⁓ But it’s, it’s been, you know, I have to say an amazing journey. And I would say when you follow for me, this is me, my life, following my passion of learning about the brain and understanding the brain and Bill Gasiamis (57:45) Yeah. Dr Bob Hedaya (58:14) looking for the fundamentals of how do things work and just there’s a common sense in medicine. I looked at the laser when I was reading that book and I was like, wow, ATP in the brain, that could really help the brain. How would I

This is one of the BEST interviews we've ever done on supplements and cutting-edge supplement technology... We had Dr. Scott Sherr on the podcast — a board-certified internal medicine physician who practices health optimization medicine and hyperbaric oxygen therapy. This guy KNOWS his stuff and we break down some of the most powerful compounds you can get your hands on to improve cognitive function, athletic performance, and longevity. Here's the reality... 94% of US adults are metabolically UNHEALTHY. That means your mitochondria — the powerhouses of your cells — are struggling to produce the energy you need. Dr. Sherr explains exactly why this happens, how it connects to everything from anxiety and depression to fat loss struggles, and what you can actually DO about it. We dive DEEP into methylene blue — the first drug ever registered with the FDA back in 1897 — and why it's become one of the most powerful tools for supporting mitochondrial function and energy production. But it doesn't stop there... We cover the GABAergic system and why most people are walking around GABA deficient (hello anxiety, insomnia, and mood issues), the synergy between methylene blue and red light therapy, how to use these compounds for travel, and a complete sleep optimization stack that could finally get you those 90+ Oura Ring scores. If you're tired of being tired, stressed about being stressed, or just want to understand how to actually support your body at a cellular level — this episode is a MUST listen. MAPS PPL — https://mapsppl.com (code: ppl) SPONSORS Troscriptions — https://troscriptions.com/mindpump (code: mindpump) Seed — https://seed.com/mindpump (code: 25mindpump) 00:00 — Intro 5:56 — Dr. Scott Sherr's background and health optimization medicine framework 10:42 — Strengths and weaknesses of conventional vs alternative medicine 16:34 — Why 94% of US adults are metabolically unhealthy 22:30 — The 'sympathetic spiral of doom' and why doing MORE isn't better 25:48 — Deep dive into methylene blue — history and mechanisms 35:09 — MAO inhibition, serotonin syndrome risk, and dosing protocols 42:43 — Methylene blue and red light therapy synergy 48:55 — GABA system, B3-GABA, and the TroCalm formula explained 59:58 — Complete sleep optimization stack and nighttime routine 67:30 — Cordycepin benefits and immune support protocols PEOPLE MENTIONED Dr. Scott Sherr — Guest — board-certified internal medicine physician, health optimization medicine practitioner, co-founder of Troscriptions Dr. Ted Achacoso — Founder of Troscriptions and the Health Optimization Medicine nonprofit, mentor to Dr. Sherr Alan Sherr — Dr. Sherr's father — chiropractor for 45+ years who influenced his alternative medicine philosophy Francisco Gonzalez Lima — Researcher at University of Texas Austin studying methylene blue for Alzheimer's, TBI, and stroke Thomas DeLauer — Mutual friend who uses methylene blue 2-3 times per week on high-stress days Paul Stamets — Referenced regarding mushroom knowledge and Amanita Muscaria/Santa Claus connection

What if feeling better didn't have to take months or years to figure out, but could start today? On this episode of The Dr. Hyman Show, I sit down with Dr. Scott Sherr to talk about why so many people feel stuck in what he calls a “sympathetic spiral of doom.” Energy is low, recovery isn't what it used to be, and there's a constant sense of stress that doesn't seem to resolve. We walk through what's actually happening beneath the surface, why it can be so hard to break out of that pattern once you're in it, and how to start shifting your energy and recovery. Watch the full conversation on YouTube, or listen wherever you get your podcasts. In this episode, we discuss: • Why you feel “tired but wired” and what it actually means for your body • What's keeping your energy low even when nothing obvious is wrong • How stress from your life and environment builds up and keeps you stuck • Why calming down doesn't always work—and what to focus on instead • How to start rebuilding your energy so your body can recover and adapt We shouldn't have to wait for something to go wrong to take action. The goal is to help your body function better so you can actually feel it day to day. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Perfect Amino, Korrus, Timeline, BON CHARGE, BIOptimizers and Pique. Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order. Visit korrus.com/drhyman for 15% off their newest product OIO Sphere with code HYMANSPHERE15. Visit timeline.com/drhyman for 20% off a subscription on top of the new starting price of $79. Head to boncharge.com/hyman and use code HYMAN for 15% off. Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%. Secure 20% off your order plus a free starter kit at piquelife.com/hyman. (0:00) Introduction and guest Dr. Scott Scherer (3:31) Understanding the sympathetic spiral of doom (5:06) Symptoms and signs of sympathetic overdrive (7:10) Sympathetic activation, mitochondrial function, and stress (10:02) Mitochondria: their role and impact in the body (12:31) Stress, metabolic dysfunction, and their effects (17:43) Nervous system, mitochondria, and the cell danger response (21:25) Survival, stress, and breaking the sympathetic spiral (23:11) Contributors to stress: top-down and bottom-up (25:56) Mitochondria, microbiome, and medication impacts (29:38) Mitochondrial dysfunction and mental health (32:19) Limitations of parasympathetic activation and addressing root causes (36:46) How mitochondrial stress leads to fight-or-flight (37:52) Steps to break the sympathetic spiral and support mitochondria (42:41) Methylene blue: benefits, uses, and safety (50:35) Methylene blue as an MAO inhibitor and for chronic infections (57:17) Case studies, third-party testing, and Transcriptions' evolution (1:02:36) Parasympathetic edge, recovery, and the GABA system (1:07:44) GABA, supplements, and interventions for stress (1:12:23) Addressing root causes and methylene blue usage (1:17:29) Transcriptions products, sleep formula, and practitioner ecosystem (1:19:49) OneBase Health, hyperbaric space, and final information

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/TimAG1 all-in-one nutritional supplement: DrinkAG1.com/TimCresset family office services for CEOs, founders, and entrepreneurs: CressetCapital.com/TimTimestamps:[00:00:00] A meditative start.[00:02:19] Reflecting on our second Zen retreat in Santa Fe with Henry Shukman.[00:04:08] Ketone liver warnings and eggplant allergies: The perils of raiding Kevin's fridge.[00:08:06] “Just be still” — three simple words that miraculously shut down my OCD.[00:13:54] Is meditation secretly vagus nerve stimulation?[00:20:17] DIY vagus nerve stim for $25 vs. Kevin's $900 ear clip.[00:24:57] HeartMath and watching your HRV move in real time.[00:27:57] Marching toward 50: balance boards and the end of jiu-jitsu.[00:31:26] Tony Hawk snowboarding Hokkaido with screws in his hip.[00:33:01] Slacklining and why your nervous system needs sleep cycles.[00:35:19] Bertolotti's Syndrome: My six-year back pain gets a name.[00:37:09] The nerve block test: everything wrong, zero pain.[00:44:10] Abrahangs tendon protocol: 10 seconds on, 50 off.[00:46:24] The NUG: a pocket hangboard for travelers.[00:48:31] Craig Mod's Japanese toothbrush and Toaster's cameo.[00:50:45] Kevin's $92 vintage fire jacket: Blue Heritage Japan.[00:54:26] Podcast picks: The Power Broker and STEM Talk.[00:56:20] Alzheimer's: A plaque or mitochondrial problem?[00:57:30] 10 grams of ketones turns one-word answers into sentences.[00:58:40] Methylene blue on Amazon: 120 years of research, zero guardrails.[01:02:36] Bredesen Protocol, APOE genotyping, and a cognitive comeback.[01:05:32] Photobiomodulation: $30k laser to the forehead.[01:07:55] Urolithin A and the high price of mitochondrial upkeep.[01:14:56] Recipe for disaster pants: espresso + creatine + MCT oil.[01:17:39] Norwegian 4×4 training and lactate as a brain lever.[01:23:15] Blood flow restriction bands and schwantz ring koans.[01:29:08] Hummingbirds named Sunset and squirrel obstacle courses.[01:32:06] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ever feel tired & anxious even when your labs look “normal”? Dr. Scott Sher explains how mitochondrial dysfunction & metabolomics reveal what's really happening at the cellular level & why optimizing your mitochondria changes energy, focus, & resilience. Meet our guest Dr. Scott Sherr is an integrative hyperbaric medicine specialist and co-founder of Troscriptions, the company behind the first commercial pharmaceutical-grade methylene blue product. He provides worldwide hyperbaric consultation, education, and advocacy. With nearly 6 years of clinical experience using methylene blue troches, he has developed protocols bridging mitochondrial dysfunction and nervous system recalibration. Dr. Sherr also co-founded Health Optimization Medicine and Practice (HOMe/HOPe), a nonprofit training clinicians in a 7-module framework for cellular health optimization. He is the founder of OneBase Health, developing next-generation sensor and app technology for health monitoring. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Your body operates as a holobiont—an ecosystem of human cells & microbes. True optimization requires influencing the entire internal network Data driven personalization beats influencer hype. Use targeted labs to build & adjust your own supplement stack over time Every organ system depends on cellular function. Optimize cells first before pursuing advanced protocols Metabolomics provides real time snapshots of unique biochemistry, guiding interventions based on actual needs Aim for optimal young adult biomarker ranges instead of settling for average aging norms Mitochondrial capacity drives cognition, recovery, & disease resistance. Most chronic issues trace back to energy dysfunction Chronic sympathetic activation locks the body in survival mode, draining cellular reserves & accelerating breakdown Short term mitochondrial support & stress downregulation create space for sustainable long term lifestyle upgrades Balanced excitatory & inhibitory neurotransmitters like GABA & glutamate support mood stability, anxiety regulation, & recovery Deep parasympathetic recovery unlocks greater cognitive & athletic return than constant stimulation or overwork Episode highlights 01:01 Holobiont concept: Why Dr. Sherr reframes biohacking as “biont hacking” 06:01 Sympathetic spiral of doom: How chronic fight-or-flight drains mitochondria 14:04 HRV as a nervous system barometer 21:25 Mitochondria beyond the textbook 41:00 Five root causes of mitochondrial dysfunction 48:50 Methylene blue as a mitochondrial bridge 50:58 GABA-glutamate imbalance in brain signaling 53:26 Obligatory pairs for GABA support 01:07:37 The parasympathetic edge for performance & recovery Links Watch it on YouTube: https://youtu.be/SImTojIu2aY  Full episode show notes: outliyr.com/252 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Methylene blue is gaining attention in functional and integrative medicine for its potential effects on mitochondria, brain health, metabolism, and even hormone balance. But what exactly is methylene blue, and how is it being used today? In this conversation, I sit down with Dr. Scott Sherr to explore the science, history, and modern clinical applications of methylene blue. We discuss how this unique compound has been used in medicine for over a century and why it is now being studied for neurological health, mitochondrial function, metabolic conditions, and more. We also explore how methylene blue may support women during perimenopause, including symptoms like brain fog, inflammation, sleep disturbances, and cognitive fatigue. In addition, we discuss its potential effects on thyroid function, mitochondrial energy production, and chronic infections such as Epstein–Barr virus. If you've been hearing about methylene blue in the biohacking or functional medicine world, this episode provides a balanced overview of the potential benefits, mechanisms, and safety considerations. In this episode we discuss: • What methylene blue is and how it works • The history of methylene blue in medicine • Mitochondrial and neurological benefits • Brain fog, inflammation, and insomnia during perimenopause • Metabolic syndrome and cellular energy • Antimicrobial effects including malaria, viruses, and Epstein–Barr virus • Using methylene blue for sore throat and immune support • Pairing methylene blue with therapies like red light therapy • Thyroid support and potential effects on T4 to T3 conversion • Mental health and psychotherapy applications • Dosing, timing, and delivery methods such as troches • Contraindications and medication interactions • Possible side effects and safety considerations Dr. Scott Sherr is a board-certified internal medicine physician and the COO of Troscriptions. He is certified in Health Optimization Medicine (HOMe) and specializes in Hyperbaric Oxygen Therapy (HBOT). Scott's mission is to make complex science easy to understand and apply. Known for clear, actionable education, he translates cutting-edge research into practical steps that improve everyday health. Find out more here; YouTube; @Drscottsherr @troscriptions Links. Websites: www.troscriptions.com www.drscottsherr.com www.homehope.org www.onebasehealth.com Instagram: https://www.instagram.com/troscriptions/ https://www.instagram.com/drscottsherr/ https://www.instagram.com/onebasehealth/ https://www.instagram.com/homehopeorg/ Linked In: https://www.linkedin.com/in/drsherr/ https://www.linkedin.com/company/troscriptions/ https://www.linkedin.com/company/onebasehealth/

It's Valentine's Day, and while we don't usually shape our work around holidays, this one felt different because we're not just co-founders of Young Goose, we're life partners. For us, care has always shown up in daily choices and consistency, the same philosophy behind how we think about skin longevity.In this special episode, we flip the format and recommend ingredients to each other based on real-time skin needs. We get into methylene blue, NAD support, ectoin, retinol, and repair-focused actives through the lens of cellular energy, inflammation control, repair, and long-term resilience.If you're listening on Valentine's Day, we're honored you're spending it with us. And if you're tuning in any other day, we're just as glad you're here. Either way, this conversation is about care that lasts and the small, intentional choices that add up over time.What's Discussed:(03:38) Why this Valentine's episode feels different as co-founders and life partners(06:11) Recommending ingredients based on real-time skin needs, not bias(12:38) Methylene blue, red light synergy, and mitochondrial skin energy(17:04) NAD support as the currency behind repair and long-term resilience(20:49) Ectoin, deep hydration, and protection from blue light and pollution(25:10) Retinol results, limitations, and why peptide alternatives matter(27:36) Sun exposure, oxidative stress, and the missing piece of post-UV DNA repairFind more from Young Goose:The Elastin Action Protocol → Engineered for Skin Navigating Elasticity Change The Winter Skin Protocol → Build for How Skin Actually Behaves in Winter VAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment RecoveryUse code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincare

Oh hey y'all.I have wanted to have this conversation for a long time, and Dr. Scott Sherr absolutely delivered.We get into what mitochondria actually do, why almost all of us are dealing with some level of dysfunction, and how energy production sits at the center of mental clarity, recovery, stress resilience, and overall health.This is one of those episodes that completely shifts how you think about your body.We also talk about methylene blue, why the internet both loves and fears it, and how to think about nervous system training, oxygen therapy, and health optimization without getting overwhelmed.This one is science heavy but incredibly practical, and honestly, I did not want it to end.Highlights:(03:09) Why mitochondria might be the missing link in modern health(09:08) The real reasons energy production breaks down over time(16:18) What health optimization medicine actually means in practice(20:30) Methylene blue explained without the hype or fear(36:25) Hyperbaric oxygen therapy, when it helps and when it does not(42:05) Building health long term while still feeling better nowConnect with Dr Scott:https://www.linkedin.com/in/drsherr/ https://www.linkedin.com/company/troscriptions/ https://www.linkedin.com/company/onebasehealth/https://www.instagram.com/troscriptions/ https://www.instagram.com/drscottsherr/https://www.instagram.com/onebasehealth/ https://www.instagram.com/homehopeorg/Qualia Mind - click hereCoupon Code: SHOCKANDYALL (15% off any purchase)Visit Nicole's on demand fitness platform for live weekly classes and a recorded library of yoga, strength training, guided audio meditations and mobility (Kinstretch) classes, as well: https://www.sweatandstillness.comGrab Nicole's bestselling children's book and enter your email for A FREE GIFT: https://www.yolkedbook.comFind Nicole on Instagram:https://www.instagram.com/nicolesciacca/Tik Tok: https://www.tiktok.com/@thenicolesciaccaFacebook: https://www.facebook.com/nicolesciaccayoga/Youtube:https://www.youtube.com/channel/UC1X8PPWCQa2werd4unex1eAPractice yoga with Nicole in person in Santa Monica, CA at Aviator Nation Ride. Get the App to book in: https://apps.apple.com/us/app/aviator-nation-ride/id1610561929Book a discovery call or virtual assessment with Nicole here: https://www.calendly.com/nicolesciaccaThis Podcast is proudly produced by Wavemakers Audio

In this episode, discover innovative dermatology compounding formulations featuring methylene blue for anti-aging skincare. Clinical pharmacist Nat Jones discusses PCCA's USP-grade methylene and the need for quality. Methylene blue may play a role in collagen stimulation, hyaluronic acid production, and UV protection. Also, learn about bio-peptide cream bases, research on carbamazepine and plaque psoriasis as well as research on losartan and hypertrophic scars. Explore evidence-based topical treatments that may be appropriate for patients in compounding pharmacies. Perfect for pharmacists seeking advanced dermatological formulation strategies and cosmeceutical applications.   Learn more by visiting our blog:   Methylene Blue: Something Old and Something Blue   Working with Methylene Blue: Best Practices for Compounding and Cleanup   Methylene Blue: From Textile Dye to Potential Clinical Wonder  

Dr. Mindy talks about Snow Days and Dr. Melaxin Eyephalt Eyebag Cream. Then she answers questions about May Thurner Syndrome, perimenopause, hair loss as a teenager, when should you take a pregnancy test, cyst removal, trigger finger, Methylene blue, root canals, fatigue, ringworm and the Wolverine Stack. https://www.youtube.com/@TheDrMindyExperiment/videosSee omnystudio.com/listener for privacy information.

You're about to learn how government approved food policies, regulatory loopholes, and corporate lobbying have quietly reshaped what's allowed in the food supply and why these decisions are driving chronic inflammation, immune dysfunction, and neurological breakdown at scale. This episode exposes how biotoxins, ultra processed ingredients, and systemic regulatory failures contribute to long COVID, POTS, mold illness, chronic fatigue, and dysautonomia and why so many people feel sick despite following official health guidance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Will Cole, a functional medicine expert who works extensively with autoimmune disease, mold illness, hormonal dysfunction, digestive disorders, and complex brain related symptoms. Dr. Cole brings years of clinical experience analyzing lab data and treating patients with biotoxin exposure, neuro immune dysregulation, and chronic fatigue patterns. Together, they connect the dots between mold exposure, post viral illness, mast cell activation, low blood pressure, and why many people with long COVID or POTS feel dizzy, inflamed, and cognitively impaired. They explain how histamine overload, electrolyte depletion, cortisol imbalance, and genetics combine to disrupt blood flow to the brain and shut down human performance. The conversation focuses on practical functional medicine and biohacking tools that help rebuild resilience at the mitochondrial and nervous system level. You'll Learn: • Why long COVID, mold illness, POTS, and chronic fatigue often share the same biological drivers • How biotoxins like mold and viral exposure dysregulate the neuro immune endocrine axis • Why low blood pressure reduces blood flow to the brain and causes brain fog and fatigue • What mast cell activation syndrome is and how histamine overload affects the body and brain • Why electrolytes, especially sodium, potassium, and magnesium, are foundational for recovery • How creatine supports brain energy, hydration, and mitochondrial function • The role of cortisol in inflammation, stress tolerance, and nervous system stability • When antihistamines and mast cell stabilizers can improve quality of life • How nicotine acts as a low dose neuroprotective compound when used carefully • The benefits and risks of methylene blue for mitochondrial and cognitive support • Why removing the trigger matters more than chasing symptoms • How a functional medicine approach rebuilds resilience instead of masking dysfunction • Why creatine absorption improves when added to hot coffee • How Danger Coffee fits into performance, hydration, and brain energy Thank you to our sponsors! - IGNITON | Go to http://igniton.com/ and use code DAVE for 15% off your first order. -TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off. -Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. -LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: long COVID, POTS syndrome, dysautonomia, mold illness, biotoxin illness, mast cell activation, histamine intolerance, low blood pressure brain fog, chronic fatigue syndrome, mitochondrial dysfunction, cortisol imbalance, electrolytes sodium potassium, creatine brain energy, functional medicine long COVID, nicotine neuroprotection, methylene blue mitochondria, brain fog causes, neuro immune dysfunction, will cole dave asprey, will cole biohacking Resources: • Dr. Will Cole's Website: https://drwillcole.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:25 - Introduction 2:20 - Conspiracy and misinformation 9:07 - Vaccine safety and fertility 12:48 - Big Food front groups 19:38 - POTS, dysautonomia, biotoxins 20:51 - HLA genetics and immunity 25:11 - Mast cells and histamine 28:41 - Electrolytes and sodium 33:37 - Cortisol and inflammation 35:01 - HPA axis burnout 39:22 - Bioidentical cortisol support 40:27 - Methylene blue and mitochondria 46:51 - Methylation and MTHFR 49:57 - Folinic acid and homocysteine 52:52 - Creatine in coffee hack See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

People with long COVID experience persistent fatigue, breathlessness, and brain fog. Research links these effects to fibrin microclots intertwined with neutrophil extracellular traps that obstruct microvessels and impair oxygen delivery SARS-CoV-2 pushes blood into a hypercoagulable state, damaging endothelium, activating platelets, and inflammatory cytokines. This causes clot risk to persist for months, even after mild infections and hospital discharge Long COVID essentially boils down to mitochondrial dysfunction. Management includes proteolytic enzymes to help clear spike protein, while the I-RECOVER protocol guides detoxification, inflammation control, and mitochondrial repair to restore overall function Protecting cardiolipin, the mitochondrial membrane fat, requires limiting easily oxidized linoleic acid (LA) from seed oils, processed foods, nuts, seeds, and grain-fed meats Methylene blue may enhance mitochondrial respiration at low doses. Additionally, correcting copper deficiency and lowering excess iron through blood donation support energy production

Get the full 15 year ad-free archive, including all 2 hour extended interviews with THC+: Subscribe via the THC website and get the Plus show on your usual podcast apps with a custom RSS feed at: http://thehighersidechats.com/plus-membership Subscribe via Patreon and get the full Plus archive, a dedicated RSS feed, THC + on Spotify, & […] The post DoeNut | Methylene Blucifer, 2026 Ritual Sacrifice, & WiFi Mantis Beings appeared first on The Higherside Chats.

In this episode, Dr. Scott A. Johnson and Dr. Scott Sherrdelve into the world of nootropics, exploring their definitions,classifications, and the importance of precision dosing. They discuss the emotional and cognitive benefits of nootropics, their impact on physical performance and recovery, and the significance of personalization in nootropic use. The conversation also touches on practical entry points for those new to nootropics and the future of precision nootropics in optimizing human performance.Connect with Dr. Scott A. Johnsonauthorscott.comFacebook Instagram YouTube Links to purchase books Connect with Dr. Sherr IG: @drscottsherr Keywords: nootropics, cognitive enhancers, brain health, precision dosing, health optimization, performance optimization, emotional benefits, physical performance, recovery, personalized medicine TakeawaysNootropics are compounds designed to support brain function.There are health optimization and performance optimization nootropics.Precision dosing is essential for effective nootropic use.Personalization is key; individual factors affect nootropic efficacy.Caffeine is the most widely used nootropic globally.Nicotine can enhance memory and focus when used correctly.Foundational health practices improve nootropic effectiveness.Methylene blue is a unique nootropic with dual benefits.Starting with low doses is advisable for new users.The future of nootropics lies in precision and personalization. Chapters00:00 Introduction to Nootropics02:33 Defining Nootropics and Their Categories08:04 Precision Dosing in Nootropics14:42 Personalization and Individual Factors in Nootropic Response19:51 Mental and Emotional Benefits of Nootropics23:28 The Impact of Hyperstimulation on Brain Function30:29 Nootropics and Physical Performance33:43 Getting Started with Nootropics40:52 The Future of Precision Nootropics44:38 Final Short Outro 2025.mp4

The Sympathetic Spiral of Doom drains your mitochondria. Here's how to rebuild energy from within.

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption. Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork. You'll Learn: • Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood • The exact signs that your dose is too strong, too weak, or in the Goldilocks zone • How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience • Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions • How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters • The link between mitochondrial health, fertility, libido, and long term anti aging strategies • How to track sleep optimization, HRV, and performance signals to dial in your personal protocol • The difference between aquarium grade dye and pharmaceutical grade formulations • Why genetic testing for G6PD deficiency is essential before higher dose experimentation Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair Thank you to our sponsors! -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 4:51 — History of methylene blue 7:38 — How methylene blue works 14:05 — Safety 17:53 — Dosing and timing guidelines 20:41 — Combining with red light therapy 22:41 — Quality and sourcing 23:17 — Dosing protocols 25:24 — Longevity and fertility effects 29:24 — Stacking options 32:10 — Common questions and FAQs 33:40 — Future research and wrap up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week on the PicklePod, we switch things up — no PPA or MLP action to recap, but a massive week of storylines, debates, and one of our favorite interviews of the year. Zane and Tice debut a brand-new segment: Build-A-Player — where each builds the “perfect” pro pickleball player using only 11 unique skills… but they can't use the same player twice. The results? Chaos, controversy, and an absolutely stacked conversation that you'll want to vote on in the comments. We also break down:

Why have we lost our trust in natural medicine? In this video, we'll discuss why natural medicine is ignored and sometimes even dismissed as folklore. Is it wise to invalidate the wisdom of the past? Discover the truth about natural medicine in this video.0:00 Introduction: Natural medicine suppression0:19 United States Dispensatory 0:38 Pharmaceutical vs. natural medicine 3:08 The advancement of medicine 6:35 Natural remedies of the past The “United States Dispensatory” by Wood and Lawall may provide insight into alternative medicine censorship in the United States. The 21st edition, published in 1926, was the most authoritative and comprehensive reference for American medicine. At the time of publication, 75% of medicine consisted of various natural remedies, while only 25% consisted of synthetic compounds.Since then, there's been a gradual transition from natural remedies to synthetic drugs. When the 22nd edition of the book was published in 1943, the ratio of natural to synthetic drugs shifted to 50:50.Today, medicine is often prescribed without considering lifestyle, eating habits, sleep patterns, stress levels, or the microbiome. Symptoms of the underlying problems are treated without addressing the root cause.Discover these 20 natural remedies that have stood the test of time, along with the ailment they have historically been used to address.1. Cod liver oil—Tuberculosis, tetany, nerve pain2. Nutmeg oil—Psychotic problems3. Olive oil—Mild laxative, gallstones 4. Pine needle oil—Eliminates mucus from the lungs 5. Castor oil—Mild laxative 6. Sandalwood oil—Gonorrhea, bronchitis, bladder infections 7. Sassafras oil—Antiseptic 8. Betaine hydrochloride—Indigestion, gastric problems9. Pepsin—Digestive issues 10. Lugol's iodine—Thyroid support and protection 11. Magnesium sulfate—Sleep support, anxiety, pain killer 12. Calcium chloride—Acidifies the body 13. Liver extract—Anemia 14. Methylene blue—Shrinks tumors, meningitis, bladder infections, gonorrhea, and supports the mitochondria15. Lithium carbonate—Relaxation, anxiety, and depression relief16. Glauber's salt—Laxative17. Vitamin D—Autoimmune conditions18. Colloidal silver19. Activated charcoal—Food poisoning, gas20. Niacin—Lowers triglycerides, increases HDL, increases lifespan, supports cardiovascular health, acts as a NAD precursorDr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the Director of Dr. Berg Nutritionals and author of the best-selling book The Healthy Keto Plan. He no longer practices, but focuses on health education through social media.Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients, so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose, and it is not a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition.

Imagine an Anarcho-libertarian future wherein philosophy, reason, and science prevail. The cathedrals of corruption looming over every nation, governments have been replaced by direct democracy on an unhackable blockchain. And with the absence of the state, perverse economic incentives, monopolies, and dogma in healthcare. In that future, will traditional allopathic medicine and healthcare be relegated to the dustbin of history and replaced entirely by frequency medicine?That's the question I explore with Dr. Zulia Frost. I interview the woman behind the Flexbeam, my favorite red light therapy device, and Clinical Director of Recharge Health. She is a world-renowned expert in neuromodulation and photobiomodulation. Her professional profile is distinguished by three decades of direct patient care - blending Western medicine with traditional modalities (Chinese Medicine and Acupuncture) and rigorous academic training, providing an authoritative lens through which to examine the burgeoning field of wearable photobiomodulation.1:22 About Dr. Zulia Frost3:48 Will allopathic medicine be replaced by frequency medicine?6:35 A case for optimism about the future8:13 Her story - a wounded healer12:53 Traditional chinese medicine and acupuncture22:04 Red light therapy cofactors24:48 Recent red light therapy science30:16 Red light therapy for sleep33:06 Red light therapy vs S.A.D.36:09 Methylene blue and red light therapy39:24 Parenting questions: red light therapy for babies (and boobies)?45:58 My experience with the FlexBeam51:45 The Recharge Health community53:15 Convincing the stubborn (and suffering) to try alternative medicine?58:06 Rant on subscription-servicization of Biohacking productsRead

Here's the Supporter-only Q&A from October 30th, 2025. All comments and questions are fielded through the supporter service Q&A page. Please consider supporting this channel via monthly support services, tips, or even just by using our affiliate links to purchase things you were already going to buy anyway, at no extra cost to you: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.retrorgb.com/support.html⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠T-Shirts: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://retrorgb.link/tshirts⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon Recommended List: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://retrorgb.link/amazon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TIMESTAMPS (please assume all links are affiliate / paid links that pay RetroRGB a commission on each sale.  Even if links are currently not affiliate, I may update them with one, should a partner list that item for sale in the future):00:00  Welcome!00:08  Integer scaling for CRT mask emulation05:26  HDMI Switches & Retro Store?06:24  Pico Loader vs Flippy Drive?:  https://www.retrorgb.com/laserbears-gamecube-pico-loader.html08:14  ShaderGlass + DuckStation Issues12:39  Methylene:  https://www.retrorgb.com/titos-fully-loaded-ps2-slim.html14:19  GB Book:  https://www.retrorgb.com/game-boy-coding-assembly-book.html16:05  Thank You!  https://www.retrorgb.com/support.html

Often pseudo-scientific medicine is brought to Dr. Sydnee by friends and family. But this time, she encountered methylene blue in the wild! Methylene blue is currently being touted as a cancer treatment, which is . . . not based on evidence. But Dr. Sydnee talks about the history of this colorful substance and what it can be actually used for.Sawbones audience feedback survey: https://forms.gle/kLXiFU8iRzAazPyn9Music: "Medicines" by The Taxpayers https://taxpayers.bandcamp.com/Border Angels: https://www.borderangels.org/

Board-certified internal medicine physician and health-optimization specialist Dr. Scott Sherr talks about parenting with presence, nervous-system regulation, mitochondrial health, and when methylene blue actually makes sense. We get practical about small, sustainable changes (especially for exhausted parents), alcohol and GABA, and why looking at your "holobiont" beats one-size-fits-all wellness. Listen if you want practical, parent-friendly strategies to protect your energy, model healthy habits for your kids and partner, and create a calmer baseline before relying on tech or supplements. WE TALK ABOUT: 05:00 - What "health optimization" really means vs. disease care 08:10 - Balancing work, partnership, and nervous-system regulation 12:35 - Sustainable micro-habits that stick 15:15 - Small changes that create big impact 17:30 - Alcohol, GABA, and the slippery slope of "relaxation" 23:05 - Methylene blue 101 and why mitochondria matter 36:15 - The holobiont lens: Optimize the whole "you," not just symptoms 44:20 - Can we actually measure mitochondrial function yet? 46:40 - When and how to use methylene blue for energy + calm SPONSORS: Feeling bloated, tired, or hormonally off? Try BiOptimizers — supplements that actually absorb and work for women's health. Get 15% off at bioptimizers.com/biohackingbrittany with code BIOHACKINGBRITTANY. Join me in Costa Rica for Optimize Her, a 5-night luxury women's retreat in Costa Rica with yoga, healing rituals, and biohacking workshops—only 12 spots available. RESOURCES: Trying to conceive? Join my Baby Steps Course to optimize your fertility with biohacking. Free gift: Download my hormone-balancing, fertility-boosting chocolate recipe. Explore my luxury retreats and wellness events for women. Shop my faves: Check out my Amazon storefront for wellness essentials. Dr. Scott Sherr's website and Instagram LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter revisits the “proven, promising, fuzzy, noise, nonsense” scale and applies it to a variety of popular topics. He begins with a refresher on what each category represents before classifying a range of interventions based on the strength of their supporting evidence. The conversation spans three main areas: drugs for geroprotection (including GLP-1 receptor agonists, SGLT2 inhibitors, methylene blue, and telomere-lengthening supplements), the use of low-dose aspirin for cardiovascular disease prevention, and strategies to improve muscle mass through optimal protein intake and follistatin gene therapy. This episode provides a clear, evidence-based overview for listeners seeking to understand where these popular health and longevity interventions stand on the spectrum of scientific credibility. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #76 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: A scale for evaluating scientific claims: proven, promising, fuzzy, noise, or nonsense [1:30]; Strong convictions, loosely held: the mindset that separates great scientists from the rest [7:30]; GLP-1 receptor agonists: are there benefits beyond improving metabolic health and promoting weight loss? [12:45]; GLP-1 drugs and the brain: exploring the potential cognitive benefits [18:45]; GLP-1 drugs and lifespan: examining the evidence for potential geroprotective effects [23:00]; Rapamycin and geroprotection: why it remains in the “promising” category [25:45]; SGLT2 inhibitors and their potential geroprotective effect [27:30]; Methylene blue: examining the evidence of an anti-aging effect [34:45]; Methylene blue's potential neuroprotective effects: limited and inconsistent evidence in humans, and the challenges of dosing and safety [41:15]; Telomeres: what they are, how they relate to aging, and why telomere-lengthening supplements lack credible scientific evidence [43:45]; Does the idea of targeting telomere length to extend lifespan have scientific merit? [50:15]; Low-dose aspirin for cardiovascular disease prevention: weighing its clot-prevention benefits against bleeding risks across different populations [55:00]; Rethinking the protein RDA: why most people need twice the recommended amount for muscle health [1:00:45]; Debunking the protein–cancer myth: why higher protein intake doesn't promote tumor growth [1:06:15]; The biology of follistatin and myostatin, and why follistatin gene therapy has become an emerging topic of interest for muscle growth [1:13:15]; Follistatin gene therapy for muscle growth: state of the evidence in animals and humans, and the technical challenges and regulatory barriers [1:17:00]; Why injectable follistatin is theoretically possible but impractical for real-world use [1:23:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Today, I'm joined by the pioneering duo behind Young Goose and two of the earliest voices to bring longevity science into the world of skincare. Amitay comes from the red light therapy space, while Anastasia's background is rooted in cancer research and regenerative medicine—together, their bold thesis is that youthful skin is not just about appearance, it's an energy state.   Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.   Episode Timestamps: Skin longevity: appearance vs resilience vs long-term health ... 00:06:42 Why topical NAD matters for skin ... 00:14:07 Importance and decline of NAD as we age ... 00:18:26 Why spermidine was added to skincare ... 00:21:00 How spermidine drives autophagy and hydration ... 00:25:43 Spermidine's impact on wrinkles and skin barrier ... 00:29:06 Longevity skincare vs traditional approaches ... 00:31:18 Methylene blue's unique benefits and formulation ... 00:34:04 Methylene blue vs other antioxidants ... 00:36:16 Methylene blue's role in recovery and protection ... 00:46:13 Platelet-derived, quantified exosomes explained ... 00:51:44 How to layer exosomes in your skincare ... 01:01:13 Biggest myths in skin longevity ... 01:02:41 Does topical NAD and spermidine really work? ... 01:08:28 Where to start with Young Goose products ... 01:19:33   Our Amazing Sponsors: Digestive Bitters by Just Thrive - One capsule before eating helps your body absorb more nutrients, ease digestion, and leave you feeling light instead of weighed down. Head over to Justthrivehealth.com/discount/NAT and use code NAT20 for 20% off. Puori: It's minimally processed, made from pasture-raised cows' milk, and it's tested for over 200 contaminants every single batch. It's also very Yummy! Go to Puori.com/NAT and use code NAT for 20% off— it also applies to subscriptions so you'll get nearly a third off the price. Thymus & Pineal BioRegulators by Natures Marvels - Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. Pineal Bioregulator supports your natural melatonin/circadian rhythm so you get the kind of sleep that underpins immune resilience. Head to profound-health.com and use code LONGEVITY15 for 15% off your first order.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Most people hear “copper peptide” and think “trend”. But GHK-Cu isn't new, it's a naturally occurring bioregulator your body already uses to repair, rebuild, and rejuvenate skin.In this episode of Biohacking Beauty, we break down why GHK-Cu deserves its cult status in longevity skincare. We also unpack how this tripeptide binds copper to signal fibroblasts, activate collagen and elastin genes, and restore damaged tissue at the cellular level. You'll learn why 3% is the sweet spot for results without irritation, how GHK-Cu works synergistically with retinol, vitamin C, methylene blue, and NAD+, and what makes pharmaceutical-grade sourcing critical for performance.If you've ever wondered whether GHK-Cu can truly “reset” aging cells or how it compares to retinol, this episode connects the dots between biochemistry and visible results, showing how small, precise molecules can drive profound, measurable change in your skin's longevity.What's Discussed:(00:00) What makes ghk-cu more than a “trendy copper peptide”(02:20) How fibroblasts, collagen genes, and epigenetics work together(07:19) Why 3% ghk-cu is the sweet spot for results without irritation(10:22) Retinol, vitamin c, and ghk-cu, the synergy your skin actually needs(18:24) Methylene blue, nad+, and the ultimate skin longevity stackFind more from Young Goose:Blue Peptide Spray – Cellular hydration meets antioxidant power → Blue Peptide SprayThe YouTH Firming Body Cream: Smoother arms, firmer thighs, tighter skin, powered by NAD+ and spermidine. Your body's anti-aging breakthrough → Body CreamSpermidine Serums: Fewer wrinkles. More collagen. Real skin renewal at the cellular level. The serum your face has been waiting for → Spermidine SerumUse code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ Instagram: @young_goose_skincare

Discover the latest science and proven strategies I've personally tested to finally conquer jet lag so you can adapt faster, boost your energy, and arrive clear-minded and ready to perform.New episodes every Friday!Episode brought to you by: ⁠⁠⁠Alive Waters⁠⁠⁠ (Code: ASHLEY)Episode brought to you by: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ARAZA Beauty⁠⁠⁠⁠Hyperlinked show notes at www.ashleydeeley.com/jetlag1:06: Fluoride is more electronegative than oxygen (this means, do not drink tap water before, during, or after your flight!)1:34: Temperature minimum (brought to you by Andrew Huberman's episode on jetlag)3:00: Theralux (not available on Amazon)3:30: Avoid sugar, alcohol, and carbs three days before a flight and during the flight3:46: Non-negotiables: wearing a hat and blue blockers5:47: Fast on all domestic flights (fast as long you can on international flights)6:14: Echo hydrogen water bottle  6:31: Quinton minerals - Quintessential 3.3 Sachets7:03: Never consume LMNT or Liquid IV8:00: Move every hour on the hour, plus drink 8-10 oz of water every hour on the hour (except when sleeping)8:41: Dr Jack Kruse says "here's how to stay grounded while flying"9:21: My VivaRays blue blockers10:14: Don't wear contact lenses while traveling10:45: Don't use air vent from above (as it's mixed with engine air)11:17:  Matthew Walker says: sleep first when you get on a plane, not last12:03: Change settings on your device to emit an orange or red hue To set your iPhone screen to red, navigate to Settings > Accessibility > Display & Text Size > Color Filters, turn on Color Filters, select Color Tint, then slide Intensity and Hue all the way to the right14:00: ⁠Melatonin from Synchronicity Health⁠14:16: ⁠Melatonin suppository⁠ (called the Sandman from Mitozen)15:50: Calm your nervous system (parasympathetic state) for travel16:09: 4-7-8 breathing by Dr. Andrew Wiel16:46: NuCalm (my FAVORITE jet lag hack)18:21: Apollo Neuro device19:27: KAATSU device20:22: VieLight redlight device Supplements for travel:21:51: Vitamin B622:09: 5-HTP22:21: Glycine22:46: MyVitalC23:43: Organic Astaxanthin24:04: NAD+ and Glutathione  bonus — Geroge Gavin: Founder of Synchronicity Health, episode 9325:58: Vitamin C from Cymbiotika / Vitamin C from BodyBio26:05: NAC26:06: CoQ10 26:09: Fish oil (THE ONLY fish oil I recommend!!!) 26:50: Glucosamine26:59: Methylene blue28:12: Dr. Tom Rogers, episode 71 on methylene blue28:35: CBD suppository (save 20% on first order with this link)   29:12: Dr. Ted Achacoso (his interview with Ben Greenfield - jet lag: start at 53:20 - Rolls Royce for hacking jet lag - uses Human Growth Hormone, thyroid hormone, testosterone at 50mg, digestive enzymes, & EPO)29:19: Portable oxygen concentrator, according to the FAA, here the approved portable oxygen concentrator brands (many require a prescription)These are apparently best brands:Inogen One (prescription required) Sequel Eclipse (prescription required) Airsep Lifestyle (or buy here too / or buy here)31:30: ⁠Progesterone⁠ (to assist females with sleep, males need a MUCH lower does) 31:49: ⁠Estrogen⁠ (for women with achy joints)31:58: ⁠DHEA⁠ 32:32: ⁠TimeShifter app⁠32:56: ⁠DSIP peptide (Delta Sleep Inducing Peptide)33:27: Grounding/Earthing upon arrival34:19: Wear silicone ear plugs and an eye mask34:38: Travel neck pillowComprehensive Supplement Guide:Stimulant:Methylene BlueNAD+MyVitalC (ESS60)Anytime:Quinton mineralsAstaxanthinGlutathioneCoQ10Vitamin CNACFish OilGlucosamineDHEAEstrogen (for women)Sleep Aid:MelatoninCBD suppository5-HTPGlycineVitamin B6Progesterone (for women)Where to find Ashley Deeley:⁠⁠⁠⁠⁠⁠⁠⁠Website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube⁠⁠⁠⁠⁠⁠hello@ashleydeeley.com

Nicotine for memory? Methylene blue for mitochondria? Dr. Josh Axe breaks down 10 controversial compounds—what the science says, what's overhyped, and the key safety and legality questions to ask before you even think about trying them. Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1 

In this episode of The Energy Code, Dr. Mike Belkowski teams up again with Don Bailey, CMO of BioLight, for a fast-paced Q&A session that delves into the essentials of mitochondrial health. Unlike last week's long-form conversation, this episode brings a rapid-fire format — Don poses questions and Dr. Mike answers in 60 seconds or less. The result? A high-energy episode that delivers bite-sized yet powerful insights into how your mitochondria drive energy, longevity, and resilience. From everyday lifestyle choices to cutting-edge supplements like methylene blue, carbon 60, and urolithin B, Dr. Mike breaks down the science of mitochondrial optimization into clear and practical takeaways. Key Topics Covered Mitochondria 101: Why they're called the power plants of the cell and why density matters for energy and health  Quality Control & Renewal: Autophagy and mitophagy as cellular “cleanup crews” clearing zombie mitochondria  Lifestyle Impacts: Sleep, light, grounding, emotional health, and EMF exposure as daily influences on mitochondrial function  Exercise & DNA: Why no single type of workout fits everyone, and how genetic differences shape exercise outcomes  Eating Patterns: Intermittent fasting, time-restricted eating, and the ketogenic diet's link to deuterium depletion   Supplement Spotlight: Methylene Blue & Lueko Methylene Blue: restoring electron flow in mitochondria and synergizing with red light  Carbon 60: a powerful regenerative antioxidant that mitigates oxidative stress  NAD Precursors (NMN/NR): boosting energy efficiency in the electron transport chain  PQQ & Urolithin B: driving mitochondrial biogenesis and clearing out dysfunctional mitochondria  Mushrooms, Shilajit, and synergistic blends in BioBlue's new Fountain of Youth supplement  Big Unknowns: What researchers still don't know about mitochondrial fusion, fission, and their roles in disease  Key Quotes from Dr. Mike “The more energy we produce per cell, the healthier we are. Less energy brings us closer to disease.” “Thoughts and emotions literally shape your mitochondrial health by imprinting on the water in your body.” “Methylene blue can literally restore energy production in a dysfunctional mitochondrion.”   Key Quotes from Don Bailey “I love this rapid-fire style — it keeps us moving from question to question, making it easier to grab key nuggets.” “That's why I talk on speakerphone all the time — I don't want my mitochondria fried by EMFs.” Episode Timeline 00:00 – Welcome & intro to rapid-fire Q&A 11:00 – Why mitochondria matter for health & energy 14:00 – Quality control: autophagy & mitophagy 18:00 – Lifestyle factors: sleep, light, emotions, EMFs 32:00 – Exercise, DNA, and mitochondrial outcomes 34:00 – Fasting, circadian alignment, and deuterium depletion 37:00 – Supplement deep dive: methylene blue, carbon 60, NAD precursors, PQQ, urolithin B, mushrooms, shilajit 56:00 – Big unanswered questions in mitochondrial research 59:00 – Closing reflections and future episode teasers Resources & References Unraveling the role of mitochondrial dynamics in cancer stem cells: Molecular basis and therapeutic implications Dr. Doug Wallace on mitochondrial bioenergetics Dr. Jack Kruse on circadian biology and EMFs BioLight Special: Save 25% when you Subscribe & Save to a BioBundle!For a BioBundle, you choose: 1.) Any one BioBlue supplement(BioBlue, BioBlue (SR), BioBlue Leuco, BioBlue Calm, BioBlue Capsules or BioBlue Leuco Capsules)2.) Any one BioC60 supplement (Regular or Concentrated)   The BioBundle automatically saves you 15% on both of the supplements you choose.You save an additional 10% by choosing to Subscribe & Save to that BioBundle.The 25% savings is passed along for every monthly delivery of your BioBundle!Discount automatically applied at checkout.   Check out the BioBundle by clicking here! Stay Connected Dr. Mike Belkowski: Instagram: @dr.mikebelkowski LinkedIn: Dr. Mike Belkowski Facebook: Mike Belkowski Don Bailey: X: @DonBaileySpeaks BioLight: Website | Instagram | Facebook

In this week's episode of The Energy Code, Dr. Mike Belkowski is joined by Don Bailey, CMO of BioLight, for an engaging and informal Q&A session diving deep into the fundamentals of mitochondrial health. This episode marks a return to the podcast's roots, offering a conversational exploration of why mitochondria are the key to unlocking limitless vitality and how to optimize their function for energy, longevity, and resilience. Dr. Mike and Don discuss the critical role of mitochondria as the powerhouse of the cell, the impact of environmental factors on energy production, and practical strategies to enhance mitochondrial efficiency. From sunlight exposure and circadian alignment to the synergistic benefits of red light therapy and methylene blue, this episode provides both a big-picture understanding and actionable insights for listeners at any stage of their health journey. Expect a blend of science, practical tips, and personal anecdotes as Don shares his transformative experience with BioLight's protocols and Dr. Mike breaks down complex mitochondrial concepts into accessible, impactful knowledge. Key Topics Covered: Why energy is the foundation of health and longevity The role of mitochondria as environmental sensors and energy producers How redox potential and electron flow impact cellular health The dangers of non-native EMFs, blue light, and chronic stress on mitochondrial function The synergistic effects of red light therapy and methylene blue for brain health and energy The connection between mitochondrial dysfunction, aging, and disease Autophagy and mitophagy: clearing out “zombie cells” for cellular renewal The importance of circadian biology and morning sunlight for mitochondrial optimization How food choices and environmental mismatch affect mitochondrial performance Key Quotes from Dr. Mike: “The more energy you produce per cell, the healthier you are. The less energy, the closer you are to disease or even cancer.” “Mitochondria are environmental sensors, reading the light in your food and the signals in your environment.” “Sunlight exposure is free and sets the stage for better sleep, better energy, and better mitochondrial function.” “Chronic stress is a mitochondrial toxin — it fries your biology at both ends of the candle.” Key Quotes from Don Bailey: “When I experienced the benefits of methylene blue and red light therapy, I knew I had to help others feel this too.” “My entire family is using these tools, and the energy output we're experiencing is phenomenal.” Episode Timeline: 00:00 – Welcome + introduction to the Q&A format with Don Bailey 01:30 – Don's journey with BioLight and the impact of red light therapy and methylene blue 05:37 – Why energy is the core of health and vitality 09:50 – Mitochondria: beyond the “powerhouse of the cell” 13:02 – Mitochondrial density in organs like the brain and heart 15:08 – Methylene blue as a mitochondrial booster and its synergy with red light therapy 20:00 – Understanding redox potential and electron flow in the body 23:36 – How non-native EMFs and poor environments lower redox potential 26:31 – Environmental disruptors: blue light, stress, and lack of movement 29:07 – The demonization of sunlight and its impact on health 30:00 – Calcium signaling and mitochondrial dysfunction 32:05 – Mitochondrial health and its direct link to aging 33:48 – Autophagy, mitophagy, and the rise of “zombie mitochondria” 39:47 – Can mitochondrial dysfunction be organ-specific? 42:13 – How food's light imprint affects mitochondrial function 45:14 – Low energy and fatigue as signs of mitochondrial dysfunction 48:35 – Practical tip: morning sunlight for circadian and mitochondrial health 51:07 – Stress reduction as a cornerstone of mitochondrial optimization 52:01 – Closing thoughts and plans for a part-two episode Resources & References: Dr. Doug Wallace on mitochondrial bioenergetics Dr. Jack Kruse on circadian biology and EMFs BioLight's BioBlue enhanced methylene blue product The Mitochondriac Manifesto 2 by R.D. Lee Quantum Return to Nature Retreat with Oksana Hanson and Carrie Bennett   Special Offer: ⚡️ LIMITED TIME DISCOUNT ON BIOBLUE! ⚡️ Boost your mitochondrial function with BioLight's BioBlue! BioBlue amplifies the benefits of red light therapy and targets metabolically dysfunctional cells, especially in the brain.   Order BioBlue today and save 15% on any quantity (single, double, four, or ten packs)! Use coupon code BIOBLUE15 at checkout. For larger quantities, enjoy even greater discounts.   Discount code: BIOBLUE15   Expires: Thursday, 9/18, midnight PST   Check out BioBlue, CLICK HERE!   Stay Connected: Dr. Mike Belkowski: Instagram: @dr.mikebelkowski LinkedIn: Dr. Mike Belkowski Facebook: Mike Belkowski Don Bailey: X: @DonBaileySpeaks BioLight: Website | Instagram | Facebook Final Note: If you enjoyed this episode, share it with a friend or family member to spread the word about mitochondrial health. Leave a five-star rating and review to help The Energy Code reach more listeners. Stay tuned for part two, where Dr. Mike and Don will dive deeper into practical strategies for optimizing mitochondrial function!

  A few months ago, Carolyn and I were sitting in a bar with a friend lamenting over our ADHD-like symptoms. Her suggested solution? Methylene blue supplements and she began to tell us how it boosted focus and attention span. Before we could say Amazon, Carolyn was adding the supplement to her shopping cart. The next day, before I purchased, I did some research and realized that while it may be fairly safe for some, there's a group of people who really shouldn't take it and I'm one of them. In today's episode, we cover what methylene blue is, when and why you might want to use it, and when you should steer clear.    References Mentioned: Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation The Potentials of Methylene Blue as an Anti-Aging Drug Exploring Methylene Blue and Its Derivatives in Alzheimer's Treatment: A Comprehensive Review of Randomized Control Trials   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com Learn More About Our Hosts:  Carolyn Williams PhD, RD: Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeatingpodcast@gmail.com Produced by Lester Nuby OE Productions  

Today, I'm joined by the remarkable Dr. John Lieurance, a true pioneer in regenerative medicine and founder of the Advanced Rejuvenation Center. In this deeply personal episode, Dr. John shares his extraordinary journey through catastrophic health challenges—including a life-threatening hospitalization, kidney failure, and the loss of his leg—and the groundbreaking therapies that not only saved his life, but allowed him to thrive.   Episode Timestamps: Dr. Lieurance discusses medical trauma & spiritual perspective ... 00:06:15 Processing fear, trauma, and emotional release ... 00:09:55 Fascia, somatic healing, and stored emotions ... 00:11:27 Challenges of hospital environments for recovery ... 00:19:19 Critique of conventional vs. functional medicine ... 00:25:08 Functional approaches to root causes and polypharmacy ... 00:32:03 Bringing in regenerative tools post-hospital ... 00:39:00 Methylene blue and high-dose melatonin protocols ... 00:39:09 Synergy of light, methylene blue, and melatonin ... 00:50:52 Dr. Lieurance's stem cell journey and Excels ... 00:53:28 “Whole food” stem cell philosophy and benefits ... 01:01:27 Inner ear regeneration with PRP, stem cells & lasers ... 01:07:43 Comprehensive tinnitus and brain protocols ... 01:15:40 Lifestyle, fasting, and hyperbaric for ear health ... 01:22:55   Our Amazing Sponsors: Stemregen - A plant-based supplement protocol designed to enhance stem cell function. support your recovery, flexibility, and long-term vitality. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order.   Lite Sunlamp by Mitolux - UVB at 295 nm to naturally boost vitamin D, plus red light for collagen and infrared for recovery. Get 10% off your MitoLux Lite Sunlamp at https://mitolux.com/NAT10. NAT10 will be automatically applied at checkout.   Timeline (NEW) - Urolithin A supports muscle strength and cellular energy. It's about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you'd get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase.    Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

In this episode of the Muscle Intelligence Podcast, Ben Pakulski sits down with Dr. Scott Sherr to uncover the hidden drivers of burnout, fatigue, and accelerated aging. Together they explore how trauma, sympathetic overdrive, and mitochondrial dysfunction silently undermine performance and recovery.   Dr. Sherr explains why 94% of adults have impaired mitochondrial health and how tools like methylene blue, metabolomic testing, and hyperbaric therapy can reset energy production at the cellular level. Whether you're a high-performing executive or simply someone feeling stuck in stress mode, this conversation provides a blueprint for balancing your nervous system, reclaiming energy, and extending healthspan.   5 Bullet Points: How trauma traps your nervous system in overdrive The link between mitochondria and lasting energy Daily practices to reset stress physiology Methylene blue's role in cellular performance Why longevity starts with cellular optimization   About Ben Ben Pakulski is the Chief Performance Officer to elite executives, successful entrepreneurs, and top athletes.With over 25 years of experience, he coaches high achievers to build the physical, psychological, and metabolic resilience required to lead at the highest level. As the creator of the Muscle Intelligence framework, Ben specializes in aligning biology and behavior to drive sustained peak performance. His mission is to redefine what's possible for people in their prime and push the boundaries of human potential.   About Dr. Sherr Dr. Scott Sherr is an internationally recognized physician and pioneer in Health Optimization Medicine. With expertise in hyperbaric therapy and metabolomics, he helps high performers restore energy, recovery, and resilience at the cellular level. As co-founder of Health Optimization Medicine, he trains physicians in metabolomics, chronobiology, and epigenetics. He also leads at Troscriptions, developing tools like methylene blue to enhance mitochondrial function and nervous system balance. His mission: move people beyond decline to lasting performance and longevity, optimizing health from the cell up.   Dr.Scott Sherr's Website: https://drscottsherr.com/ Dr. Scott Sherr's Instagram: @drscottsherr

Discover 8 powerful supplements that deliver multiple health benefits in this comprehensive episode! We'll cover Berberine, Castor Oil, Thiamine, Collagen, Curcumin, Huperzine A, Black Seed, and Methylene Blue - each offering unique support for gut health, inflammation reduction, cognitive function, joint mobility, and skin health. These science-backed natural compounds can help optimize your wellness routine by targeting multiple body systems simultaneously. Always consult with your healthcare provider before starting any new supplement regimen, this content is for educational purposes only.    ✅Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/  

We face a disciplinary crisis as the twin pillars of Game Theory and Gurometry are called into question.The full episode is available to Patreon subscribers (1 hour, 35 minutes).Join us at: https://www.patreon.com/DecodingTheGurusSupplementary Material 3500:05 Introduction 01:52 Matt's Apology06:55 Just Life...12:34 Matt's Foodie Corner 14:01 Dedunking Dan Richards finds Sabine16:37 Sabine cultivates parasocial defenders18:16 Ana Kasparian gets deeper into ZOG conspiracies24:44 Gary vs Game Theory40:26 Support the Channel to Save the World47:10 Bryan Johnson and Methylene blue51:52 Scientific Cosplay Online53:51 Keith Rainiere and Sensemaking Parallels54:57 High IQ YoungHoon Kim tweets about proof of God56:19 Guru and Cult Leader Parallels01:01:13 The Validity of the Gurometer in Question?!?01:03:03 Hacking Social Heuristics01:07:38 Cult Leaders vs Secular Gurus01:12:33 Anti-Democratic moves by Trump01:15:03 Dan Carlin on Trump01:18:30 Streamers Talking Nonsense: Hasan on ISIS01:21:24 Ideological Fixation and Motivated Conspiracism01:27:22 OutroSourcesThe Cushendun Sea Caves from Game of ThronesKingdom Come: Deliverance 2 is Boosting TourismDeDunking: Eric Weinstein's Theory — Real Physicist vs Pseudo PoserAna Kasparian tweeting about the “Zionist Occupied Government”Gary's Economics: Game Theory is BrokenCritical Reddit thread on Gary's Game Theory videoHenrich, J., McElreath, R., Barr, A., Ensminger, J., Barrett, C., Bolyanatz, A., ... & Ziker, J. (2006). Costly punishment across human societies. Science, 312(5781), 1767–1770.The Selfish Gene, Chapter 12: Nice Guys Finish First (Richard Dawkins)High IQ YoungHoon Kim tweets about proof of GodI was Jordan Peterson's strongest supporter. Now I think he's dangerousDan Carlin's tweet about TrumpBBC: National Guard troops appear in Washington DC as mayor rejects Trump's 'authoritarian push'Nathan Baker: Keith Raniere, Ringleader of NXIVM Sex Slave Cult, Interviewed by Allison Mack, Top Cult...

In this unique solosode of The Red Light Report, Dr. Mike Belkowski debuts a brand-new format — breaking down and rebutting claims from another health podcast, The Medical Medium, which recently aired an episode titled Methylene Blue: Why It's a Problem.   Dr. Mike methodically addresses the statements made by host Anthony William, point by point, providing science-backed explanations, clinical context, and mitochondrial physiology to counter misinformation about methylene blue. From the basics of redox potential and mitochondrial water production to its synergy with red light therapy, Dr. Mike explains why methylene blue remains one of the most promising mitochondrial support tools — and why some common criticisms don't hold up under scientific scrutiny.   Expect a fascinating mix of science, myth-busting, and practical takeaways for anyone curious about methylene blue, mitochondrial health, and how to navigate conflicting health advice in the age of information overload.   Key Topics Covered: Why The Red Light Report will soon have a new name The limitations of the “Mitochondrial Triad” model and what's next The science of methylene blue vs. common misconceptions How redox potential impacts health more than diet alone The truth about methylene blue, electrolytes, and hydration Why methylene blue's blue pigment is key to its benefits The synergy between methylene blue and red light therapy How methylene blue supports brain health, cognition, and neuroprotection Methylene blue's role in ATP production and mitochondrial water creation When methylene blue may (and may not) be a concern for the liver   Key Quotes from Dr. Mike:   “Life is powered by electron flow — not calories, not minerals. Electrons are the fuel your mitochondria run on.” “That blue pigment isn't just pretty — it's the reason methylene blue works so well with red light therapy.” “Methylene blue doesn't have an antioxidant in it. It is the antioxidant.”   Key Points: 00:00:27 – Podcast name change announcement & future direction 00:02:56 – Expanding beyond the Mitochondrial Triad 00:04:01 – Why rebutting misinformation matters 00:10:07 – Methylene blue & electrolytes: myth vs. fact 00:17:56 – Is bitterness a sign of harm? 00:25:42 – Redox potential explained 00:36:02 – Top ways to improve redox potential 00:40:13 – How methylene blue works as an antioxidant 00:46:45 – Why the blue pigment is beneficial 00:51:53 – Methylene blue & hydration 00:57:04 – Bioactivity and mitochondrial effects 01:02:15 – Nervous system benefits & neuroprotection 01:08:01 – Methylene blue and the liver: the real story 01:12:12 – Final thoughts on evaluating health claims - BLUE SPECIAL THIS WEEK...SAVE 20% ON ALL BIOBLUE SUPPLEMENTS!! For a BioBundle, you choose: Choose from our wide range of BioBlue products — four varieties of liquid BioBlue and four varieties of encapsulated BioBlue. Discount code: BLUEPODCASTExpires Thursday, 8/21, midnight PST*Discount code is not valid with bundles or 2-, 4- or 10-packs. Must use "single" option and then increased to desired quantity.   To view all BioBlue products, click here! - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram Facebook

In this eye-opening episode, renowned naturopathic doctor and neurological health expert Dr. John Lieurance reveals why melatonin is not just for sleep—it's a cellular protector, cancer inhibitor, and cornerstone of chronic illness recovery. Explore the cutting-edge science behind: High-dose melatonin therapy and its powerful anti-inflammatory, anti-aging effects Revolutionary treatments for Lyme disease, mold toxicity, and long-haul illness How mitochondria and the pineal gland hold the keys to energy, healing, and consciousness Methylene blue, regenerative medicine, and other powerful tools for cellular optimization The biohacks Dr. Lieurance personally used to rebuild his health This isn't just about better sleep. It's about unlocking your body's ability to heal, perform, and thrive. Whether you're battling chronic fatigue or looking to level up your longevity game, this conversation will change the way you think about health. Hit play. Your mitochondria will thank you. Thank You to Our Sponsors Laird Superfood - High-quality ingredients paired with incredible taste. Use the code GABBY20 for 20% off your purchase at lairdsuperfood.com Lineage - Get 15% Off Lineage Provisions with the code GABBY at lineageprovisions.com/gabbyreece today. Troscriptions - Give it a try at troscriptions.com/GABBY or enter GABBY at checkout for 10% off your first order.  For more on Gabby Instagram @GabbyReece: https://www.instagram.com/gabbyreece/ TikTok @GabbyReeceOfficial https://www.tiktok.com/@gabbyreeceofficial The Gabby Reece Show Podcast on YouTube: YouTube: https://www.youtube.com/@GabbyReece  Follow Dr. John Lieurance on:  Instagram - https://www.instagram.com/drjohnlieurance/?hl=en  You can order Dr. Lieurance's book "Methylene Blue: Magic Bullet" now - https://tinyurl.com/xrafjt76  Host: Gabby Reece; Produced by Rainbow Creative (https://www.rainbowcreative.co/) (Executive Producer: Matthew Jones; Editor: Patrick Edwards; Story Producer: Sean Leviashvili; Sr. Content Strategist & Creative Producer: Alexandra Fugère; Sponsorships Lead: Lauren Feighan; YouTube Growth Team: Zac Stein & Jason Al-Samarrie CHAPTERS 0:00 Melatonin and Cancer: A Surprising Connection 03:41 Dr. John Laurenz's Journey into Natural Medicine 07:47 The Role of Mitochondria in Chronic Illness 15:04 Melatonin: Beyond Sleep 23:28 Methylene Blue: Benefits and Misconceptions 37:09 Melatonin's Role in Fighting Inflammation and Disease 50:18 Suppositories and Their Benefits 53:09 Melatonin: The Ultimate Health Hack 59:14 Functional Cranial Release and Brain Health 01:14:16 Emotional Release Techniques Learn more about your ad choices. Visit megaphone.fm/adchoices

In this re-released solo episode from 2023, Dr. Mike Belkowski revisits one of the most pivotal topics in the world of mitochondrial health: methylene blue. As interest in this powerful compound continues to grow, Dr. Mike brings back an essential conversation outlining its top ten benefits — from brain function and mood to immune support to antiviral activity and beyond!   He also shares exciting updates about the future of the podcast, including a rebrand launching in August and a major expansion of the Mitochondrial Triad into the Mitochondrial Core Four. You'll also hear about BioLight's newest supplement, BioBlue Fountain of Youth, and how combining methylene blue with red light therapy can lead to powerful healing synergy.   Whether you're brand new to methylene blue or a longtime user, this episode will deepen your understanding of why this blue dye might just be the missing link in your health toolkit. If you care about energy, mood, memory, immunity — or just want to future-proof your brain — this episode is packed with insights you won't want to miss! - Key Quotes from Dr. Mike Belkowski: “Red light therapy and methylene blue on their own are powerful tools. But when you use them together, you're getting a synergistic benefit that may be unmatched in the world of mitochondrial health.”   “The more I read, the more I research, the more I realize: this compound that started as a dye might be one of the most important mitochondrial tools we have.”   “Methylene blue has been around since the 19th century. It's safe, it's effective, and the amount of research backing its antiviral, neuroprotective, and metabolic benefits is staggering.”   Key Points:   00:00 – Introduction: A Podcast Rebrand and New Direction   03:11 – Evolving the Mitochondrial Triad into the Core Four   05:17 – Why Methylene Blue Deserves a Second Look   07:15 – BioBlue: A New Mitochondrial-Enhancing Supplement   10:45 – NMN, Folic Acid, and Gold-Silver Nanoparticles Explained   11:07 – The History of Methylene Blue: From Textile Dye to Healing Tool   15:11 – Fish Tanks, Surgery, and the Safety of MB   17:57 – Malaria Cures and Forgotten Medicine   20:16 – BioBlue FOY: The Cadillac of Mitochondrial Supplements   21:38 – Methylene Blue + Red Light = Antiviral Powerhouse   22:29 – Cognitive Enhancement, Memory, and Focus Support   23:00 – Rapid Mood Shifts and Depression Relief   24:26 – Reversing Alzheimer's: A Look at the Research   29:25 – How MB Boosts Mitochondrial Energy at the Molecular Level   31:31 – Hormonal Benefits: More Energy, Less Estrogen, Higher Testosterone   32:00 – MB as an Antidote for Poisoning and Metabolic Toxins   36:29 – Methylene Blue's Powerful Antiviral Capabilities   44:12 – Alzheimer's Hallmarks Reversed with MB and Red Light Therapy   55:11 – Autism, Gut Health, and Restoring Mitochondrial Function   58:44 – The Nitric Oxide Link to Depression and Brain Fog   01:03:07 – Bipolar and Mood Stabilization Studies with MB   01:04:27 – Autism, Oxidative Stress, and Endotoxin Insights   01:13:33 – MB as a Rapid Pain Reliever for Surgery and Chronic Conditions BLUE SPECIAL THIS WEEK... SAVE 20% ON ALL BIOBLUE SUPPLEMENTS!!   Choose from our wide range of BioBlue products — four varieties of liquid BioBlue and four varieties of encapsulated BioBlue. Need help figuring out which BioBlue makes the most sense for you? Respond to this email!Discount code: BLUEPODCAST Expires Thursday, 8/7, midnight PST*Discount code is not valid with bundles or 2-, 4- or 10-packs. Must use "single" option and then increased to desired quantity.   Shop all BioBlue products by clicking here! - Dr. Mike's #1 recommendations:Water products: Water & WellnessGrounding products: Earthing.com EMF-mitigating products: Somavedic Blue light blocking glasses: Ra Optics  

There's a thief entering the health and wellness space and it's called methylene blue. Methylene blue would be a wonderful addition in the healing world if it only offered something good, just one thing positive, if it offered just one little, helpful quality to contribute in the world of illness and healing, but unfortunately, it doesn't, and never will. For one, methylene blue is a salt that is void of all salt, void of all electrolytes, but not just void of all electrolytes…it's an electrolyte robber, taker, an electrolyte thief that, when enters the body, is far from a good thing for anyone who has a chronic illness or a neurological condition, vagus nerve problem or any issues at all with a sensitive central nervous system. That means that if someone has any kind of anxiety whatsoever, methylene blue will rob electrolytes that are critically needed for neurotransmitter function, which will then lead to worsened forms of anxiety. What does methylene blue possess? Nothing. It has no amino acids, no enzymes, no trace minerals, no macro minerals, no proteins, no nutrients, no phytochemical compounds, no antiviral compounds, no antibacterial compounds, no glucose, no vitamins, and the list goes on. Biohackers love methylene blue because it's an easy sell to desperate people who are chronically ill and are on the search for the next possible breakthrough in health. But methylene blue won't be the answer. What it will do, like many other trends have done in the past, is make bank for certain individuals and drain the pockets of people on their last leg who suffer. In this episode, you will learn much more about methylene blue and you can then be well informed to make your own decision on if it's right for you… In this episode… Learn how methylene blue is void of all nutrients, minerals, trace minerals, enzymes, amino acids, electrolytes, vitamins, and any phytochemical compounds. Discover how methylene blue creates chronic dehydration in the body from continual use. Find out why methylene blue is harmful to someone who has autoimmune or is battling chronic illness or symptoms and conditions. Become aware that methylene blue is really a pharmaceutical by design. Learn how methylene blue is not bioactive and isn't applicable to any of our body's needs. See how methylene blue is the new biohacker flavor of the year, yet has nothing to offer anyone who has chronic illness. Become aware of how methylene blue is going to split the penny with other trends that aren't helpful as well for the human body. Learn how bovine colostrum does not support an adult's health and how it only supports a baby calf's health. Find out how human babies can only benefit from human colostrum from their human mothers. All this and more, tune in and don't miss out on this important episode. You can revisit this episode anytime you need it. For more information visit www.medicalmedium.com

In this solo episode of The Red Light Report, Dr. Mike Belkowski shares something truly special — an in‑depth solo episode based on his presentation at the Quantum Health Retreat in Nashville at the end of June: The Bioenergetics of Methylene Blue. However, this episode is the expanded version of that presentation with extra context and nuance. This lecture is Dr. Mike's attempt to pull back the curtain on methylene blue, a re‑emerging powerhouse compound that's reshaping how we think about energy, longevity, and mitochondrial health; but from a quantum perspective,    You'll learn how methylene blue works as both an electron donor and acceptor, how it synergizes with red light therapy to amplify mitochondrial output, and why supporting your mitochondria is foundational for longevity, disease prevention, and peak vitality. Mike explores bioenergetics, oxidative stress, structured water, electron tunneling, spin‑dependent biochemistry, and photodynamic therapy — all explained in an accessible, engaging way with plenty of practical takeaways.   Key Topics Covered: Methylene blue as a quantum biological agent: electron flow, redox cycling, and mitochondrial support. How methylene blue plus red light therapy can increase neuronal ATP production by up to 80%. Practical dosing guidance, timing tips, and safety considerations. Quantum concepts like electron tunneling, photonic resonance, and structured water—and how they relate to your health. The importance of sun exposure, melanin, and building your “solar callus.”  

There are more toxic byproducts in food dyes than in many drugs. These synthetic food colorants have never been tested long-term for biological effects in humans! Many food dyes have been banned in Europe, but are still used in the U.S. Junk food industries that sell products with food dyes are heavily self-regulated, so the FDA allows them to perform their own studies. In 2021, there was a petition to ban red dye number 3 in cosmetics because it's a carcinogen even in small amounts, but it can still be found in your child's cereal. Artificial food coloring has been shown to cause hyperactivity in children and other neurological issues. Food dyes are often used for their psychological effects. Studies have shown that people will choose to eat more of a food because of its color.Natural pigments in our food have antioxidant properties, anti-inflammatory effects, help protect your cells, and protect the mitochondria. You can also get these phytonutrients when you consume grass-fed beef or lamb. Methylene blue is a synthetic, petroleum-based food dye that benefits your health. It was one of the first drugs ever developed, and unlike other artificial food dyes, methylene blue is pharmaceutical grade. It's been used for Alzheimer's, Parkinson's, bladder infections, cancer, and more.Methylene blue is chemically different from other artificial food dyes. It helps give the body energy, even when there's damage to the mitochondria. It's beneficial for degenerative neurological disorders and reduces oxidative stress associated with cancer and mitochondrial damage. Artificial food coloring does not have the benefits of the pigments found naturally in food. They don't act as antioxidants or reduce inflammation in the body. They damage the mitochondria, and they don't have nutritional cofactors.Artificial food dyes have been linked to ADD and tumors in rats. They can cause leaky gut, and their effects are worsened when combined with preservatives and other food chemicals. Some food dyes are bioaccumulative, which means they build up in the body. The kidneys effectively eliminate methylene blue, so it doesn't accumulate.Dr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media.

There are more toxic byproducts in food dyes than in many drugs. These synthetic food colorants have never been tested long-term for biological effects in humans! Many food dyes have been banned in Europe, but are still used in the U.S. Junk food industries that sell products with food dyes are heavily self-regulated, so the FDA allows them to perform their own studies. In 2021, there was a petition to ban red dye number 3 in cosmetics because it's a carcinogen even in small amounts, but it can still be found in your child's cereal. Artificial food coloring has been shown to cause hyperactivity in children and other neurological issues. Food dyes are often used for their psychological effects. Studies have shown that people will choose to eat more of a food because of its color.Natural pigments in our food have antioxidant properties, anti-inflammatory effects, help protect your cells, and protect the mitochondria. You can also get these phytonutrients when you consume grass-fed beef or lamb. Methylene blue is a synthetic, petroleum-based food dye that benefits your health. It was one of the first drugs ever developed, and unlike other artificial food dyes, methylene blue is pharmaceutical grade. It's been used for Alzheimer's, Parkinson's, bladder infections, cancer, and more.Methylene blue is chemically different from other artificial food dyes. It helps give the body energy, even when there's damage to the mitochondria. It's beneficial for degenerative neurological disorders and reduces oxidative stress associated with cancer and mitochondrial damage. Artificial food coloring does not have the benefits of the pigments found naturally in food. They don't act as antioxidants or reduce inflammation in the body. They damage the mitochondria, and they don't have nutritional cofactors.Artificial food dyes have been linked to ADD and tumors in rats. They can cause leaky gut, and their effects are worsened when combined with preservatives and other food chemicals. Some food dyes are bioaccumulative, which means they build up in the body. The kidneys effectively eliminate methylene blue, so it doesn't accumulate.Dr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media.

Hey Heal Squad! Get ready to learn how to radically boost your energy, immune system, and brain health—naturally. In Part 1, Maria sits down with Dr. Jonas Kuehne, renowned integrative physician and regenerative health expert, to break down everything you need to know about mitochondrial health—including how to use it as your body's first line of defense against chronic illness and even cancer. We're talking methylene blue, melatonin production, vitamin D, and even the truth behind controversial (but promising) therapies like ivermectin and fenbendazole. Dr. Jonas also explains the science behind red light, grounding, and how your body's healing potential increases exponentially when you optimize your light, sleep, and nutrient exposure. From reversing brain fog to metabolic healing and cancer prevention—this episode is filled with real tools and science-backed hope. You don't want to miss this one! HEALERS & HEAL-LINERS: Mitochondria are the engines of your body. Boosting their function can increase energy, slow aging, and even prevent disease. Methylene blue is a powerful mitochondrial support. At the right dose, it helps brain function, fights pathogens, and may even aid in cancer recovery. Controversial doesn't mean ineffective. Repurposed drugs like ivermectin and fenbendazole show promise in cancer treatment—and Dr. Jonas explains why science (not stigma) should lead the way. -- HEAL SQUAD SOCIALS IG: https://www.instagram.com/healsquad/ TikTok: https://www.tiktok.com/@healsquadxmaria HEAL SQUAD RESOURCES: Heal Squad Website:https://www.healsquad.com/ Heal Squad x Patreon: https://www.patreon.com/HealSquad/membership Maria Menounos Website: https://www.mariamenounos.com My Curated Macy's Page: Shop My Macy's Storefront Prenuvo: Prenuvo.com/MARIA for $300 off Delete Me: https://bit.ly/43rkHwi   code: SQUAD EPISODE RESOURCES: Instagram: https://www.instagram.com/dr.jonas.kuehne/  Website: http://www.jonasmd.com Youtube: https://www.youtube.com/@JonasKuehneMD  Cryo Healthcare: https://www.cryohealthcare.com/?fbclid=PAZXh0bgNhZW0CMTEAAaeeU6H7MNMsAm5HIjcNleJrRLnokvOYUGLe9LXN-ayts3HPaHLVb2cqVaPKHw_aem_bbgV2vuCpxgV6l6T1w9ceQ  Face Lifter: https://www.facelifter.com/?fbclid=PAZXh0bgNhZW0CMTEAAae34sptRGBD2YTWovchpdiWvvIP1fPapkn42gz2ao_J-JSq-yg1w_HSLaedYQ_aem_Y17-S3O73cBe3WMV-5yDRw ABOUT MARIA MENOUNOS: Emmy Award-winning journalist, TV personality, actress, 2x NYT best-selling author, former pro-wrestler and brain tumor survivor, Maria Menounos' passion is to see others heal and to get better in all areas of life. ABOUT HEAL SQUAD x MARIA MENOUNOS: A daily digital talk-show that brings you the world's leading healers, experts, and celebrities to share groundbreaking secrets and tips to getting better in all areas of life. DISCLAIMER: This Podcast and all related content (published or distributed by or on behalf of Maria Menounos or http://Mariamenounos.com and http://healsquad.com) is for informational purposes only and may include information that is general in nature and that is not specific to you. Any information or opinions provided by guest experts or hosts featured within website or on Company's Podcast are their own; not those of Maria Menounos or the Company. Accordingly, Maria Menounos and the Company cannot be responsible for any results or consequences or actions you may take based on such information or opinions. This podcast is presented for exploratory purposes only. Published content is not intended to be used for preventing, diagnosing, or treating a specific illness. If you have, or suspect you may have, a health-care emergency, please contact a qualified health care professional for treatment.

Cutting Edge Peptide Fat Loss & Muscle Building with Alex Kikel What's the deal with methylene blue? (2:02) His background in the peptide space. (9:09) How common is it for a professional athlete to have someone work with them who is NOT their doctor? (11:22) Why he believes there is not a biological problem he cannot fix. (12:38) How nicotine is protective of long COVID symptoms. (13:37) The effects and benefits of nicotine. (15:12) How would he program these things to an athlete? (17:48) Can we counter the effects of microplastics in our brain? (21:07) The common stacks for the busy entrepreneur. (25:41) Earning the right to get these peptides/stacks. (32:50) The common stacks for bodybuilders. (35:37) His go-to growth hormone release peptides. (55:53) Favorite healing peptides. (57:00) Are GLP-1s being used pre-contest in the bodybuilding world? (1:01:44) Breaking down the libido-enhancing PT-141 peptide. (1:05:32) His thoughts on artificial sweeteners. (1:07:25) Why he believes our world is in a renaissance right now. (1:08:53) Being open to EVERYTHING. (1:10:42) What's he pumped up about? (1:14:45) His take on longevity experts, like Bryan Johnson. (1:16:26) His case against sunscreens. (1:18:48) Related Links/Products Mentioned Visit Eight Sleep for an exclusive offer for Mind Pump Listeners! ** Code MINDPUMP to get $350 off Pod 4 Ultra. Currently, it ships to the United States, Canada, the United Kingdom, Europe, and Australia. ** MAPS Transform Special Launch! ** Code TRANSFORM70 at checkout. $70 Off Gym + At Home workouts. Includes: Adam's 90-Day Body Recomp Journal, and the MAPS Transformation Diet Guide. ** Methylene blue: The anti-aging liquid RFK Jr. seems to drink Neural Rx - Wizard Sciences What is SLU-PP-332, the Exercise Mimicking Drug? L-Carnitine Injection For Fat Loss: Benefits & Side Effects Noopept: Benefits, Dosage, Side Effects, Drug Interactions Jonathan Butts | Water Revitalization, Structured Water, & Natural Action Tech Mind Pump # 2360: What You Need to Know About GLP-1 With Dr. Tyna Moore Bremelanotide: Recommended PT-141 Dosage for Results Don't Die: The Man Who Wants to Live Forever - Netflix Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Alex Kikel (@alex_kikel) Instagram Website YouTube Jay Campbell (@jaycampbell333) Instagram Paul Chek (@paul.chek) Instagram Mark Bell (@marksmellybell) Instagram BioLongevity Labs (@biolongevitylabs) Instagram