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PeerView Clinical Pharmacology CME/CNE/CPE Audio Podcast
Sonia Glennie, ARNP, MSN, OCN, AGPCNP-BC - Moving Beyond Conventional Care for DLBCL: Oncology Nurse Leadership for the Effective and Safe Use of Innovative Antibody and Cellular Therapies

PeerView Clinical Pharmacology CME/CNE/CPE Audio Podcast

Play Episode Listen Later Sep 22, 2022 35:02


Go online to PeerView.com/ZUH860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Nurses play an essential role in caring for patients with diffuse large b-cell lymphoma (DLBCL); learn more about the core elements of nursing practice in this PeerView video activity, featuring two leading oncology nurses who will focus on novel antibody and CAR-T cell therapies for the management of R/R DLBCL. Using a case-based format, the panelists will detail how antibodies and CAR-T therapy are now a part of the treatment toolkit and provide guidance on important considerations including: therapeutic sequencing, safety concerns, and counseling patients on appropriate dosing, treatment schedules, and premedication recommendations. Upon completion of this activity, participants should be better able to: Cite current clinical evidence supporting the integration of novel antibody and CAR-T cell therapies for the management of diffuse large B-cell lymphoma (DLBCL); Educate patients on safety, dosing, and treatment expectations associated with novel CD19, CD79, and CD3/CD20 targeting antibodies in the DLBCL setting; Counsel patients on the therapeutic role of cellular therapy in DLBCL, efficacy expectations, unique pre-therapy requirements, and adverse events such as CRS and neurotoxicity; and Manage practical considerations with novel antibodies and CAR-T therapy in DLBCL, including coordination of clinical visit or referral to specialized care, dosing considerations, and management of unique adverse events.

Ben Ferguson Morning Update
VICTORY! 33 senators call for Hunter Biden special counsel, cite DOJ ‘politicization'

Ben Ferguson Morning Update

Play Episode Listen Later Sep 21, 2022 32:12


VICTORY: 33 senators call for Hunter Biden special counsel, cite DOJ ‘politicization'See omnystudio.com/listener for privacy information.

Devotionale Audio
Eliberator pentru poporul Sau 21.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 20, 2022 3:56


Ce minune ar fi nevoie să facă Isus în viața familiei mele astăzi? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Below the Radar
A Walk Around The Sun — with Erika Lewis

Below the Radar

Play Episode Listen Later Sep 20, 2022 19:30


Erika Lewis is a singer and musician of Tuba Skinny, a blues and ragtime band from New Orleans. Erika is also a solo artist, with the albums, “Waiting for Stars” (2016) and “A Walk Around the Sun” (2022). This episode goes into the different musical influences of New Orleans, Erika's move from blues to country, and her overall experiences of street busking and touring internationally. There is also a discussion of her health scare and how it pushed the release of her latest album. This episode contains excerpts from songs from Erika's album A Walk Around the Sun, courtesy of the artist. Full episode details: https://www.sfu.ca/vancity-office-community-engagement/below-the-radar-podcast/episodes/186-erika-lewis.html Read the transcript: https://www.sfu.ca/vancity-office-community-engagement/below-the-radar-podcast/transcripts/186-erika-lewis.html Resources: Erika Lewis: https://www.erikalewismusic.com/full-bio Tuba Skinny: http://tubaskinny.com/ A Walk Around The Sun: https://lnk.to/aroundthesun The Bomb Shelter: https://www.bombshelterstudio.com/ Bio: Known for her lengthy tenure touring and busking with beloved New Orleans jazz band Tuba Skinny, prolific songwriter and singer Erika Lewis has been churning out American originals all her own for the past several years. From classic country to cosmic Americana to dreamy indie folk, Lewis continues to dip her toes more deeply into an ever-expanding pool of roots music styles. Her latest record, “A Walk Around the Sun” (2022), is a testament to Lewis' songwriting prowess and exceptional vocal ability. Cite this episode: Chicago Style Johal, Am. “A Walk Around the Sun — with Erika Lewis” Below the Radar, SFU's Vancity Office of Community Engagement. Podcast audio, September 20, 2022. https://www.sfu.ca/vancity-office-community-engagement/below-the-radar-podcast/episodes/186-erika-lewis.html.

The Ben Maller Show
Hour 4 – Conflict of Interest

The Ben Maller Show

Play Episode Listen Later Sep 20, 2022 42:49


In hour four of The Ben Maller Show, Big Ben sticks with the NFL and dives into the 1 game suspension Mike Evans received after coming to his quarterback's defense on Sunday. Plus, another edition of Cite the Byte and much more!See omnystudio.com/listener for privacy information.

Laurent Gerra
PÉPITE - Fabrice Luchini rend hommage à Michel Drucker et cite du Céline

Laurent Gerra

Play Episode Listen Later Sep 19, 2022 2:03


Fabrice Luchini était sur RTL pour rendre hommage à Michel Drucker, invité spécial de Laurent Gerra. L'acteur a notamment révélé les secrets de longévité de l'animateur de télévision...

Devotionale Audio
Mantuitor înviat 20.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 19, 2022 4:12


Este Duhul Sfânt turnat asupra mea în prezent? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

John Solomon Reports
Job Creators Network President: 65% of small business owners cite ‘crime' as reason for closing, relocation

John Solomon Reports

Play Episode Listen Later Sep 19, 2022 39:37


Elaine Parker, President of Job Creators Network, discusses their new poll showing that 65% of small business owners cited crime as forcing them to consider to move to another location or close entirely, and that for minority small business owners that number jumps to 85%. Parker explains that coming out of the pandemic, people “can see how blue states are setting themselves apart, they're failing at every turn from the red states, and really setting themselves apart. The red states have continued to thrive in spite of a federal government that is doing them no favors. Crime has become a major issues in the cities.” The President cites a recent example last week, that “McDonald's announced that they're very concerned about crime for their stores in the city of Chicago.” Saying, “Chicago continues to be the sort of the poster child for this but there's a lot of cities that are running neck and neck, are almost first place with them.” Parker says that these companies are starting to speak out because the White House and Congress have “a complete, almost denial, just detachment from what is really happening.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

EM Board Bombs
147. Caustic ingestions: hide your kids, hide your bleach

EM Board Bombs

Play Episode Listen Later Sep 18, 2022 19:56


Want to experience the greatest in board studying? Check out our interactive question bank podcast- the FIRST of its kind here: emrapidbombs.supercast.com. Hide your kids or hide your bleach. Let's talk about a classic tox presentation this week! Cite this podcast as: Briggs, Blake. Episode 147: Caustic Ingestions: hide your kids, hide your bleach. https://www.emboardbombs.com/podcasts/147-caustic-ingestions-hide-your-kids-hide-your-bleach. September 18th, 2022. Accessed [date]

Medicine via myPod
147. Caustic ingestions: hide your kids, hide your bleach

Medicine via myPod

Play Episode Listen Later Sep 18, 2022 19:56


EM Board Bombs Want to experience the greatest in board studying? Check out our interactive question bank podcast- the FIRST of its kind here: emrapidbombs.supercast.com. Hide your kids or hide your bleach. Let's talk about a classic tox presentation this week! Cite this podcast as: Briggs, Blake. Episode 147: Caustic Ingestions: hide your kids, hide your bleach. https://www.emboardbombs.com/podcasts/147-caustic-ingestions-hide-your-kids-hide-your-bleach. September 18th, 2022. Accessed [date] https://www.listennotes.com/e/edaf00fc159c4d09a0932359a04a49b1/

Devotionale Audio
Marele exemplu 19.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 18, 2022 4:29


Cum aș putea să gestionez mai bine insultele și ura de care mă voi lovi când Îl voi face cunoscut pe Hristos? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Maiestate a cerului 18.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 17, 2022 3:54


Sunt eu deplin conștient de realitatea că Maiestatea cerului dorește să aibă o relație personală cu mine? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Imparat in neprihanire 17.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 16, 2022 3:38


Felul în care Îl privesc pe Isus îmi modifică modul de a-i vedea pe oamenii din jur? Cum îmi schimbă dorința de a-L servi pe Hristos? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

On n'est pas obligé d'être d'accord - Sophie Durocher
«Ce que je trouve nauséabond, c'est quand on cite le titre d'un livre et qu'on se fait traiter de raciste», dit Sophie Durocher

On n'est pas obligé d'être d'accord - Sophie Durocher

Play Episode Listen Later Sep 16, 2022 2:35


Segment éditorial de Sophie Durocher : le tour de l'actualité avec Sophie Durocher.Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

Devotionale Audio
Mire ceresc 16.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 15, 2022 3:41


Fecioarele înțelepte au avut lumină când aveau cea mai mare nevoie de ea. Ce responsabilitate am pentru a menține lumina arzând în întunericul moral intens? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Pregações e Aulas - Igreja Presbiteriana de Santo Amaro
2. Deus se Vinga de Nossos Adversários (Isaías 1.21-31) - Daniel Santos

Pregações e Aulas - Igreja Presbiteriana de Santo Amaro

Play Episode Listen Later Sep 15, 2022 37:12


Pregador: Daniel Santos Passagem: Isaías 1.21-31 Antes da mensagem O profeta Isaías foi usado por Deus para levantar sérias acusações e ameaças contra a cidade de Jerusalém, mais especificamente, contra seus líderes e governantes. Leia o texto da mensagem (Isaías 1.21-31) e tente responder às seguintes perguntas: 1) Quem são as pessoas para quem as ameaças do texto estão sendo dirigidas? 2) Cite dois exemplos do que tais pessoas têm feito que as tornam alvo da ira de Deus. Depois da mensagem Como vimos na mensagem, nosso Deus está atento e ativo contra a corrupção que permeia a sociedade. Embora a estrutura social, econômica e política de Jerusalém nos dias do Antigo Testamento sejam bem diferentes do nosso contexto hoje, qual dos problemas tratados nesta mensagem afeta diretamente a sua vida?

Devotionale Audio
Cel care vine 15.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 14, 2022 3:39


Îi dau eu ocazia lui Satana să-mi umple mintea cu simțămintele lui? Cum să-mi protejez mintea de influențe negative? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

The Ben Maller Show
Best of The Ben Maller Show

The Ben Maller Show

Play Episode Listen Later Sep 13, 2022 41:07


Big Ben talks about Russell Wilson and the Broncos falling to the Seahawks, Jerry Jones' search for a veteran QB, Maller to the Third Degree, Cite the Bite, and much more!See omnystudio.com/listener for privacy information.

Devotionale Audio
Fanana de fericire 14.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 13, 2022 4:08


În ce măsură depun eu eforturi intenționate pentru dezvoltarea puterilor mele fizice și intelectuale? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Below the Radar
Science Fiction & Social Justice — with Walidah Imarisha

Below the Radar

Play Episode Listen Later Sep 13, 2022 26:22


Situated within the current context of police brutality, for-profit prisons, and excessive incarceration rates, Am Johal sits down with educator, writer, and public scholar, Walidah Imarisha. Walidah describes her creative works involving ideas and futures of police and prison abolition, including her book Angels with Dirty Faces, and her current work developing Space to Breathe – a film that looks back on our present moment of the abolitionist movement from a future where police and prisons have been abolished. She also shares her collaboration with adrienne maree brown in the creating the Octavia's Brood, an anthology inspired out of their desire to push movement organizers beyond ideas if “realistic” change. Throughout the interview Walidah also speaks about science fiction as an avenue to inspire greater imaginings for social change, and discusses white supremacy, imperial colonialism, and white “progressiveness” within the past and present histories of Oregon and The United States. Full episode details: https://www.sfu.ca/vancity-office-community-engagement/below-the-radar-podcast/episodes/185-walidah-imarisha.html Read the transcript: https://www.sfu.ca/vancity-office-community-engagement/below-the-radar-podcast/transcripts/185-walidah-imarisha.html Resources: Octavia's Brood: Science Fiction Stories from Social Justice Movements: https://www.akpress.org/octavia-s-brood.html Walida's website: https://www.walidah.com/ Below the Radar with adrienne maree brown: https://www.sfu.ca/vancity-office-community-engagement/below-the-radar-podcast/episodes/166-adrienne-maree-brown/ Space to Breath film: https://www.walidah.com/blog/2021/3/24/grant-recipient-for-sci-fi-documentary-film Angels with Dirty Faces: https://www.akpress.org/angelswithdirtyfaces.html What a City Is For by Matt Hern: https://www.akpress.org/angelswithdirtyfaces.html Bio: Walidah Imarisha is an educator, writer, public scholar and spoken word artist. She has co-edited two anthologies, Octavia's Brood: Science Fiction Stories From Social Justice Movements and Another World is Possible. Imarisha's nonfiction book Angels with Dirty Faces: Three Stories of Crime, Prison, and Redemption won a 2017 Oregon Book Award. She is also the author of the poetry collection Scars/Stars, and in 2015, she received a Tiptree Fellowship for her science fiction writing. Imarisha is currently an Assistant Professor in the Black Studies Department and Director of the Center for Black Studies at Portland State University. In the past, she has taught at Stanford University, Pacific Northwest College of the Arts and Oregon State University. For six years, she presented statewide as a public scholar with Oregon Humanities' Conversation Project on several topics, including Oregon Black history. She was one of the founders and first editor of the political hip hop magazine AWOL. She has toured the country many times performing, lecturing and challenging, and has shared the stage with folks as different as Angela Davis, Cornel West, Amiri Baraka, Nikki Giovanni, Kenny Muhammad of the Roots, Chuck D, Michael Franti and Spearhead, Robin D.G. Kelley, Umar bin Hassan from The Last Poets, Boots Riley, Saul Williams, Ani DiFranco, John Irving, dead prez, Rebecca Solnit, and Yuri Kochiyama. Cite this episode: Chicago Style Johal, Am. “Science Fiction & Social Justice — with Walidah Imarisha.” Below the Radar, SFU's Vancity Office of Community Engagement. Podcast audio, September 13, 2022. https://www.sfu.ca/vancity-office-community-engagement/below-the-radar-podcast/episodes/185-walidah-imarisha.html.

The Ben Maller Show
Hour 4 - Taking Receipts

The Ben Maller Show

Play Episode Listen Later Sep 13, 2022 35:41


Ben Maller talks about Robert Saleh sending a message to those that are mocking the Jets and how he would rate Saleh's tenure so far, Cite the Bite, and much more!See omnystudio.com/listener for privacy information.

Devotionale Audio
Invatator si salvator al omenirii 13.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 12, 2022 3:32


Apreciez eu indicațiile de la Dumnezeu transmise prin profeții din vechime? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Piatra unificatoare 12.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 11, 2022 3:46


Ce pot face astăzi pentru a contribui la unitatea creștină pe care Hristos a venit să o aducă în casa, biserica și localitatea mea? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Nazarinean crucificat 11.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 10, 2022 3:41


Ce lecție nouă m-a învățat crucea despre dragostea infinită a lui Dumnezeu? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Miel al lui Dumnezeu 10.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 9, 2022 3:29


De câte ori ar trebui să primesc sacrificiul ispășitor al lui Hristos pentru păcatele mele? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Semanator ceresc 09.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 8, 2022 3:47


Ce sămânță pot să semăn astăzi pentru Împărăția lui Dumnezeu? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Usa la Staulul lui Dumnezeu 08.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 7, 2022 2:59


Dacă Isus este ușa staulului pentru turma lui Dumnezeu, care este rolul meu ca ajutor de păstor, lucrând pentru El și împreună cu El? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Print care avea sa vina 07.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 6, 2022 3:25


Dacă fariseii și cărturarii din timpul lui Isus și-au putut pierde complet convingerea de păcat, cum aș putea să evit această fatalitate în viața mea? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

The Ben Maller Show
Hour 4 - Bowles Backs Brady

The Ben Maller Show

Play Episode Listen Later Sep 6, 2022 36:28


Ben Maller talks about Bucs head coach Todd Bowles dismissing questions about Tom Brady's dedication to the team, Cite the Bite, and much more!See omnystudio.com/listener for privacy information.

Devotionale Audio
Autor al salvarii noastre 06.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 5, 2022 3:53


Când în cursul zilei de azi îmi voi examina motivele acțiunilor? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Unsafe Space
[Episode 0848] [Narrative Dissonance] The State vs. Parents | With L (SomeB*tchIKnow)

Unsafe Space

Play Episode Listen Later Sep 5, 2022 142:14


Juliet and Carter are joined by L (SomeB*tchIKnow) to discuss the state's war against parents, but the conversation meanders into a variety of topics, including Neopets, LARPing as a frog, neopronouns, lederhosen, chronic wasting disease, conspiracy theories, the elitist origins of the Department of Education, 8-hour work days, Dan Schneider and the Nickelodeon / Disney child star pipeline, and California's "sanctuary state for trans children" legislation. L (a.k.a. SomeBitchIKnow) is the relentless researcher behind SomeBitchMedia and the personification of its tagline: ”Cite your sources or GTFO.” She's helped explode mainstream narratives around the COOF, The 2020 Election, Jeffrey Epstein & Ghislaine Maxwell, and other issues. Follow her on Gab at: @SomeBitchIKnow The video version of this episode is available here: https://unsafespace.com/ep0848 Links Referenced in the Show: Chronic wasting disease: https://www.cdc.gov/prions/cwd/index.html Illiberal Refoermers: http://digamoo.free.fr/leonard2016.pdf California's Cradle to Career system: https://c2c.ca.gov/ Women over 45 carry canes: https://twitter.com/TerriGerstein/status/1566468151155560449 About Narrative Dissonance "Narrative Dissonance" is a weekly series dedicated to shattering the narrative of the mainstream press. Each week, a team of panelists from alternative media sources unravel the latest misleading mainstream narratives and explore relevant stories that journalists in the corporate press ought to be covering, but aren't. Thanks for Watching! The best way to follow Unsafe Space, no matter which platforms ban us, is to visit: https://unsafespace.com While we're still allowed on YouTube, please don't forget to verify that you're subscribed, and to like and share this episode. You can find us there at: https://unsafespace.com/channel For episode clips, visit: https://unsafespace.com/clips Other video platforms on which our content can be found include: LBRY: https://lbry.tv/@unsafe BitChute: https://www.bitchute.com/channel/unsafespace/ Also, come join our community of dangerous thinkers at the following social media sites...at least until we get banned: Censorship-averse platforms: Gab: @unsafe Minds: @unsafe Locals: unsafespace.locals.com Parler: @unsafespace Telegram Chat: https://t.me/joinchat/H4OUclXTz4xwF9EapZekPg Censorship-happy platforms: Twitter: @_unsafespace Facebook: https://www.facebook.com/unsafepage Instagram: @_unsafespace MeWe: https://mewe.com/p/unsafespace Support the content that you consume by visiting: https://unsafespace.com/donate Finally, don't forget to announce your status as a wrong-thinker with some Unsafe Space merch, available at: https://unsafespace.com/shop

Devotionale Audio
Adevarata sursa de iertare si pace 05.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 4, 2022 3:44


A adus pace în viața mea adevărul îndreptățirii prin credința în Isus? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

The Republican Professor
This Attorney Challenged California's "Assault Weapon" Ban in Federal Court and Won: John Dillon, Miller v. Bonta (Decided 4 June 2021) (TRP Episode 85)

The Republican Professor

Play Episode Listen Later Sep 3, 2022 67:20


TRP Episode 82 on YouTube: Civil Rights attorney John Dillon, a prevailing attorney against California's so-called "assault weapon" definition and ban, reacts to the US Supreme Court's decision in NY Rifle & Pistol Assn v. Bruen (issued Thursday 23 June 2022). His victory in federal trial court against the so-called California Department of Justice came last summer, June of 2021, in Miller v. Bonta decided 4 June 2021. Interesting for our purposes here, the Judge Benitez's (Cuban ancestry) reasoning in striking down the ban as a violation of the Second Amendment was essentially the same reasoning used by the high Court in Bruen. Benitez used the Heller test, as he called it, before, and in addition to the flawed reasoning that the 9th Circuit had developed to counteract Heller, because they don't like Heller. You can and should read that very readable, well-argued Miller decision for yourself here : https://scholar.google.com/scholar_case?case=5854039725887452071&q=miller+v.+bonta&hl=en&as_sdt=2003 Feel free to tell me if I'm wrong in the comments. But make sure you base your argument in the text of Miller and in the text of Bruen. Cite those sources. (Good luck in that). You can read the Bruen decision here : https://www.supremecourt.gov/opinions/21pdf/20-843_7j80.pdf John goes into a little of his backstory, as well, of how he personally got into this topic. He did not grow up as a "gun guy." He was a normal undegrad a UCLA. It's possible he partied a little too much. But he majored in History. He did well in school. He decided to go to Law School also in LA at Loyola. It was during law school there in LA that he went shooting at a club in LA and decided to buy his own firearm. There began his journey through the Alice in Wonderland type of web of irrational bureaucratic criminalization scheme that California and LA have enacted in the name of "public safety" and "police power." Police power, in these jurisdictions (like New York), could be symbolized with a fist in the air, power to the police, the police state. Innocence as a definition be damned. The once clear line between guilt and innocence in the California criminal law is now blurred, constantly moving, and sometimes not in line with anything approaching rationality or commonsense. John Dillon began to take it as his mission in life to expose that to the world for what it is. Referenced in this episode is also Justice Thomas's dissent from denial of cert in Sylvester v. Harris, here : https://www.supremecourt.gov/opinions/17pdf/17-342_4hd5.pdf ^ It's short, read it . Get informed. It's also a delight to read because it's so well-written. The Republican Professor is a pro-effective-legit-advocacy, pro-Second-Amendment-rightly-understood, pro-Cuban-federal-judges-who-get-that-government-can't-just-make-stuff-up-to-increase-power-at-the-expense-of-innocent-people, pro-Black-justices-who-were-raised-under-Democratic-segregation-(where-there-was-a-real-Klan)-who-get-the-Second-Amendment podcast . Therefore, welcome John Dillon, the prevailing attorney in Miller against Bonta (the Calif DOJ) on 4 June 2021. The Republican Professor is produced and hosted by Dr. Lucas J. Mather, Ph.D. The latest issue of Police State Magazine (Berkeley, Ca) has recently voted TRP #6th scariest publication for Statists who want to grow their Police State, behind the Bible, the Declaration of Independence, the US Constitution, the corpus of Alexander Solzhenitzen, and Mila 18 by Leon Uris. We're honored. Thank you. Very humbling. #grateful Be sure to subscribe and share. This is TRP Episode 85 on Apple Podcasts, Orange Podcasts, Yellow Podcasts, etc.

Devotionale Audio
Comandant iubit 04.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 3, 2022 3:37


Când a fost ultima dată când Cerul s-a bucurat că regret comiterea unui anumit păcat? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Singurul ajutor 03.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 2, 2022 3:53


Când m-am împotrivit eu milei iertătoare a lui Isus doar pentru a-L vedea venind cu și o mai mare manifestare de dragoste plină de compasiune? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Datator al vietii 02.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Sep 1, 2022 4:09


Îl cunosc eu pe Cel în care am crezut și care este singura mea speranță? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

AP Audio Stories
Feds cite efforts to obstruct probe of docs at Trump estate

AP Audio Stories

Play Episode Listen Later Aug 31, 2022 0:53


AP Washington correspondent Sagar Meghani reports on Trump-FBI, voicer 312

Devotionale Audio
Cel mai loial prieten 01.09.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Aug 31, 2022 3:50


Prieteniile adevărate cer timp, atenție, părtășie și grijă. Cât de adevărată este prietenia mea cu Isus? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Devotionale Audio
Medic plin de compasiune 31.08.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Aug 30, 2022 4:00


Ar trebui să-I cer lui Dumnezeu vindecare pentru cei care s-au îmbolnăvit din cauza îngăduinței de sine? Ar putea redobândirea sănătății lor să le schimbe comportamentul? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

Below the Radar
The Creative Instigator's Handbook — with Leanne Prain

Below the Radar

Play Episode Listen Later Aug 30, 2022 34:05


Leanne Prain is the writer of The Creative Instigator's Handbook: A DIY Guide to Making Social Change and Yarn Bombing: The Art of Crochet & Knit Graffiti. In this episode, Melissa Roach and Leanne discuss the inspiration for The Creative Instigator's Handbook, the different range of projects and artists described in the book, the impact of the pandemic, and the creativity of “Do It Yourself” art projects. Full episode details: https://www.sfu.ca/vancity-office-community-engagement/below-the-radar-podcast/episodes/183-leanne-prain.html Read the transcript: https://www.sfu.ca/vancity-office-community-engagement/below-the-radar-podcast/transcripts/183-leanne-prain.html Resources: Leanne Prain: https://www.leanneprain.com/about The Creative Instigator's Handbook: A DIY Guide to Making Social Change through Art: https://arsenalpulp.com/Books/T/The-Creative-Instigator-s-Handbook Godfrey Stephens and the Weeping Cedar Woman of Clayoquot Sound: https://www.godfreysart.com/weeping-cedar-woman Morris and Helen Belkin Art Gallery: https://belkin.ubc.ca/ Jenny Hart: https://sublimestitching.com/pages/jenny_hart Smokey D: https://www.cbc.ca/news/canada/british-columbia/respect-chinatown-art-exhibit-1.6493781 Aram Han Sifuentes: https://www.aramhansifuentes.com BE MIGHTY: https://medium.com/bemighty/learning-to-be-mighty-chapter-1-e744a9b2b110 Thomas Dambo: https://thomasdambo.com Dave Eggers - The Spirit of the Animals is in the Wheels: https://daveeggers.net/spirit Laura Farina: https://www.sfu.ca/continuing-studies/instructors/e-h/laura-farina.html Maker Faire: https://makerfaire.ca The Dinner Party by Judy Chicago: https://www.brooklynmuseum.org/exhibitions/dinner_party/ Ravelry: https://www.ravelry.com/tour/getting-started Yarn Bombing: The Art of Crochet and Knit Graffiti: https://arsenalpulp.com/Books/Y/Yarn-Bombing Bio: Leanne Prain helps communities connect through creative ideas. A writer, speaker and certified design professional, her previous books include Yarn Bombing: The Art of Crochet & Knit Graffiti, and Strange Material: Storytelling through Textiles. Her latest book The Creative Instigator's Handbook: A DIY Guide to Making Social Change through Art was published in 2022. Cite this episode: Chicago Style Roach, Melissa. “The Creative Instigator's Handbook — with Leanne Prain.” Below the Radar, SFU's Vancity Office of Community Engagement. Podcast audio, August 30, 2022. https://www.sfu.ca/vancity-office-community-engagement/below-the-radar-podcast/episodes/183-leanne-prain.html.

The Ben Maller Show
Hour 4 – Shadow Puppeteer

The Ben Maller Show

Play Episode Listen Later Aug 30, 2022 40:40


In the final hour of the show Ben talks about how Cowboys owner Jerry Jones could be the shadow commissioner of the NFL and the man behind the iron curtain. Ben also reacts to RJ Barrett's rookie extension with the New York Knicks, and Alex Rodriguez's rocky attempt to buy the Minnesota Timberwolves. Ben hears from Dick in Dayton, Cowboy in Windsor and other Maller regulars, plus, another great edition of “Cite the Bite.”See omnystudio.com/listener for privacy information.

Devotionale Audio
Cel adorat de ingeri 30.08.2022 [devotional audio]

Devotionale Audio

Play Episode Listen Later Aug 29, 2022 3:28


Cum s-au simțit îngerii văzându-L pe Isus suferind? Citește acest devoțional și multe alte meditații biblice pe https://devotionale.ro #devotionale #devotionaleaudio

The Ben Maller Show
Hour 4 - The Brady Treatment

The Ben Maller Show

Play Episode Listen Later Aug 23, 2022 41:44


Ben dives into the Tom Brady camp saga in Tampa! Listen to Maller go-in on the special treatment of Mr. Inflation. There's a Vegas headliner that NFL fans are trolling and Cite the Bite will have you biting kneecaps! See omnystudio.com/listener for privacy information.

B2B Content Show
3 strategies for creating B2B content that cuts through the noise w/ Fara Rosenzweig

B2B Content Show

Play Episode Listen Later Aug 18, 2022 18:00


Fara Rosenzweig, Head of Content Marketing at WorkRamp, talks with Jeremy about ways to differentiate content.Highlights:Why a journalistic approach to writing creates strong content and is beneficial in the B2B worldHow gong calls directly contribute to creating unique contentThe benefits of doing in-depth research when creating written piecesLearn more about WorkRampConnect with Fara on LinkedInMemorable Quotes:"My approach and my philosophy to make it different is, I go back to what did I learn early on in my career about making good content when I was working on a magazine and it's, hey, you have to be a good writer, strong writer. Have your sources. Cite your facts. You need to be unbiased.""You're hearing firsthand what your ideal target audience want and what they need, what their confusions are. So from a marketing standpoint, that's how we can then solve problems.""Content needs to be of value. You can't just put fluff out there. You can't just make it whatever's going on in your brain. it's not gonna resonate to your target audience."

Discover CircRes
August 2022 Discover CircRes

Discover CircRes

Play Episode Listen Later Aug 18, 2022 32:38


This month on Episode 39 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 5th and 19th issues of the journal. This episode also features an interview with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University on their article, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension.   Article highlights:   Jain, et al. Role of UPR in Platelets   Orlich et al: SRF Function in Mural Cells of the CNS   Xue et al: Gut Microbial IPA Inhibits Atherosclerosis   Wang et al: Endothelial ETS1 on Heart Development   Cindy St. Hilaire:        Hi, welcome to Discover CircRes, the podcast of the American Heart Association's journal Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting articles from our August 5th and August 19th issues of Circulation Research. I'm also going to have a chat with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University about their study, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension.   But before I get to the interview, I first want to share an article from our August 5th issue, and that article is titled, Unfolded Protein Response Differentially Modulates the Platelet Phenotype. The first author of this study is Kanika Jain and the corresponding author is John Hwa from Yale University. Self-stress can lead to protein misfolding, and the accumulation of misfolded proteins can lead to a reduction in protein translation and may alter gene transcription, a process collectively known as the unfolded protein response, or UPR. UPR is well documented in nucleated cells; however, it has not been studied in platelets, which are anuclear, but do have a rapid response to cellular stress. In this study, they investigated the UPR in anucleate platelets and explore its role, if any, in platelet physiology and function.   They found that treating human and mouse platelets with various stressors caused aggregations of misfolded proteins and induction of UPR-specific factors. Oxidative stress, for example, induced the UPR kinase PERK, while an endoplasmic reticulum stressor induced the transcription of the UPR factor XBP1. The team went on to study the UPR in platelets from people with type II diabetes, which is a population in which platelet mediated thrombosis is a major complication. They showed that protein aggregation and upregulation of the XBP1 pathway in diabetic patient platelets correlated with disease severity. Furthermore, treating the diabetic patient platelets with a chemical chaperone that helps to correct protein misfolding reduced protein aggregations and prevented the cells prothrombotic activation. This work confirms that even without transcription, platelets display stress-induced UPR, and that targeting this response may be a way to reduce thrombotic risk in diabetic patients.   Cindy St. Hilaire:        The second article I want to share with you is from our August 5th issue and is titled, Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow, and it was led by Michael Orlich from Uppsala University in Sweden. Blood vessels are lined with endothelial cells and surrounded by mural cells. Vascular smooth muscle cells are the mural cells in the case of veins and arteries, and pericytes are the mural cells in the case of capillaries. In the capillaries, pericytes maintain blood-brain and blood-retina barrier function and can mediate vascular tone, similar to smooth muscle cells. While these pericytes and smooth muscle cells are related, they have distinct roles and characteristics.   To learn more about the similarities and the differences between pericytes and smooth muscle cells, this group examined how each would be affected by the absence of SRF in the other. SRF is a transcription factor, essential for nonvascular or visceral smooth muscle cell function. In visceral smooth muscle cells, SRF drives expression of smooth muscle actin and other smooth muscle genes. Using mice engineered to lack SRF in mural cells, they show that SRF drives smooth muscle gene expression in these pericytes and smooth muscle cells, and its loss from smooth muscle cells causes atrial venous malformations and diminishes vascular tone. In pericytes, loss of SRF impaired cell migration in angiogenic sprouting. In a mouse model of retinopathy, activation of SRF drove pathological growth of pericytes. This work not only highlights the various functions of SRF in mural cell biology, but it also suggests that it has a role in pathological capillary patterning.   Cindy St. Hilaire:        The third article I want to share is from our August 19th issue of Circulation Research and is titled, Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease. The first authors are Hongliang Xue and Xu Chen, and the corresponding author is Wenhua Ling from Sun Yat-Sen University in Guangzhou, China. Recent studies provide evidence that disorders in the gut microbiota and gut microbiome derived metabolites affect the development of atherosclerosis. However, which and how specific gut microbial metabolites contribute to the progression of atherosclerosis and the clinical relevance of these alterations remain unclear. Gut microbiome derived metabolites, such as short-chain fatty acids and trimethylamine N-oxide, or TMAO, have been found to correlate with atherosclerotic disease severity.   This study has now found that serum levels of indole-3-propionic acid, or IPA, are lower in atherosclerosis patients than controls. The team performed unbiased metagenomic and metabolomic analyses on fecal and serum samples from 30 coronary artery disease patients and found that, compared with controls, patients with atherosclerosis had lower gut bacterial diversity, depletion of species that commonly produce IPA and lower levels of IPA in their blood. Examination of a second larger cohort of atherosclerosis patients confirmed this IPA disease correlation. The team also showed serum IPA was reduced in a mouse model of atherosclerosis, and that supplementing such mice with dietary IPA could slow disease progression. Analysis of the macrophages from these mice showed that IPA increased cholesterol efflux, and the team went on to elucidate the molecular steps involved. The results of this study not only unraveled the details of IPA's influence on atherosclerosis, but suggest boosting levels of this metabolite could slow atherosclerotic disease progression.   Cindy St. Hilaire:        The last article I want to share is also from our August 19th issue, and it's titled, Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction. The first author is Lu Wang and the corresponding author is Paul Grossfeld, and they are at UCSD. Congenital heart defects, or CHDs, are present in nearly 1% of the human population. In some cases, the heart defects result from a genetic error, which can give researchers clues to its etiology. Jacobson syndrome is a complex condition caused by deletions from one end of chromosome 11, and the occurrence of a congenital heart defect in this syndrome has been associated with the loss of the gene ETS1. ETS1 is an angiogenesis promoting transcription factor, but how ETS1 functions in heart development was not known.   Wang and colleagues now show that both global or endothelial-specific loss of ETS1 in mice caused differences in embryonic heart development that ultimately led to a muscular wall defect known as ventricular non-compaction. The mice also had defective coronary vasculogenesis associated with decreased abundance of endothelial cells in the ventricular myocardium. RNA sequencing of ventricular tissue revealed that, compared with controls, mice lacking ETS1 had reduced expression of several important angiogenesis genes and upregulation of extracellular matrix factors, which together contributed to the muscular and vascular defects.   Cindy St. Hilaire:        Today I have with me, Dr Annet Kirabo and Dr Ashley Pitzer, both from Vanderbilt University, and we're going to talk about their paper, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. This article is in our August 5th issue of Circulation Research. Thank you both so much for joining me today.   Annet Kirabo:             Yeah, thank you so much for having us.   Ashley Pitzer:              Yeah, thank you for having us.   Cindy St. Hilaire:        Yeah, it's a great paper. I think we're all familiar with hypertension and this idea that too much salt is bad for our cardiovascular system. When I was a kid, my grandparents had those salt replacements on their kitchen table, Mrs. Dash and whatever. But, like you said in the start of your paper, the exact mechanism by which salt intake increases blood pressure and also increases cardiovascular risk, it's not really well understood, and you guys are focusing on the contribution of immune responses in this process or in this pathogenesis. Before we dig into the details of your paper, I was wondering if you could give us a little bit of background about what's known regarding the role of inflammation in this salt-sensitive hypertension pathogenesis.   Annet Kirabo:             Yeah. It's difficult to know where begin to from, but the role of inflammation in cardiovascular disease have been known for many, many decades. Right now, Dr David Harrison showed more than 10 years ago that T cells contribute to hypertension, but the mechanisms were not known. Back when I was a post doc in David Harrison's lab, we discovered a new mechanism, how immune cells are activated in inflammation and hypertension, whereby we found that there is increased oxidative stress in antigen-presenting cells. This leads to formation of oxidative products known as arachidonic acid or lipid products known as isolevuglandin, or IsoLGs. These IsoLGs are highly, highly reactive and they adapt to lysines on proteins. This is a covalent binding, which leads to permanent alteration of proteins, and so these proteins act as neoantigens that are presented as self-antigens to T cells, leading to an autoimmune-like state in hypertension.   Annet Kirabo:             We found that these antigen-presenting cells are activated and they start producing a lot of cytokines that paralyze T cells to IL-17 producing T cells that contribute to hypertension. And so, when I started my lab back in 2016, we discovered that excess dietary salt profoundly activates this pathway, and we found for the first time that these antigen-presenting cells, they express ENaC, the epithelial sodium channel, and sodium goes into these antigen-presenting cells and activates the NADPH oxidase, which is an enzyme which produces this reactive oxygen species, leading to this IsoLG formation, which I've talked about, and leading to inflammation.   So, three years ago when Ashley joined my lab, she had extensively studied the inflammasome in her PhD program, and she suggested why don't we look at the role of the inflammasome in this pathway and how IsoLG may contribute to this. In her paper that we are discussing right now, she found that in a dependent manner, sodium enters the cell and activates this pathway, and the NLRP3 inflammasome is involved in this process.   Cindy St. Hilaire:        That's such a wonderful story that fits together so many pieces. One of the things you talk about, which I guess I didn't even appreciate myself is, there are certain individuals out there who are more salt-sensitive than others.   Annet Kirabo:             Yeah.   Cindy St. Hilaire:        What is that difference? Do we know the root cause of that? And then also, how many individuals are we talking about are salt-sensitive?   Annet Kirabo:             Salt-sensitive blood pressure, it is a variable trait and it's normally distributed in the population, but it happens more in some individuals than others. It happens even in 25% of people without any hypertension. These people go to that doctor, that doctor thinks they're normal, they don't have any hypertension, but these people can be at a risk of sudden heart attack or cardiovascular risk or even a stroke, simply because when they eat a salty meal, their blood pressure will go up.   Cindy St. Hilaire:        Yeah, that's one of my questions. How much salt are we talking about here? And not only how much in a meal, but a sustained amount? How bad is a miso soup a day?   Annet Kirabo:             Yes. The American Heart Association and the World Health Organization have recommendations. American Heart Association recommends one spoon per day. We have refused to adapt to this recommendation, but that is the recommendation that they have recommended per day to eat. But this is difficult because most of the salt, as you know, is already in our food through processing in our processed foods and we don't have any control over how much salt we have, and there's also a lot of adding of salt at a table.   Cindy St. Hilaire:        Ashley, your background was more the inflammasome. What were your thoughts entering into this project? Did you have much of a hypertension background?   Ashley Pitzer:              No. My graduate thesis focused mainly on endothelial dysfunction and cardiovascular disease, and so it was a pretty easy segue. But it was just with Annet, so excited about the project and showing me all the data and this robust IL-1 beta production that she was seeing after these immune cells being exposed to high salt, I, with my inflammasome background, was immediately like, this could be playing a role. And so it was, like I said, a pretty easy transition and, as is in the paper, we're doing human studies. All of my research back in grad school was very basic research, so it was very exciting to see how our research was being translated with people having this condition and potentially finding mechanisms where we can target this to help actual people.   Cindy St. Hilaire:        I think a lot of us who are not in the hypertension field, and maybe this was you before you joined Annet's lab, we really only kind of think of the kidneys and the blood vessels when we think about hypertension, but studies like this are changing that. And I think a lot of Annet's earlier work, as well as the work of others, have shown a role for this epithelial sodium channel as an important player in this salt-induced hypertension. New to me, it's not just found in the kidney, which I totally did not appreciate that. And it's this channel sensing the salt that can trigger this IL-1 beta production that does a whole bunch of other things.   Cindy St. Hilaire:        What are those other things? What are those cells that are affected and where is this happening? Obviously it's not just kidney cells, but is it only in the kidney or are these systemic cells? What do we think is happening?   Ashley Pitzer:              That's the question, is, where is this happening? There's been studies at Vanderbilt by Jens Titze and his lab showing, where are these immune cells sensing the salt? And so they've shown that sodium accumulates in the skin, a huge argument is for they're sensing the sodium in the kidney because that's where a lot of it is being processed. But these immune cells travel through the whole body, so they're seeing it where there are the highest amounts of sodium concentration, and so I would argue it's in the kidney.   Annet Kirabo:             Indeed, because we're now collaborating with Tina Kon, and we have recently published with her a paper in the International Journal of Science, where we have done sodium MRI and we find this accumulation of sodium in the kidney even much more than in the skin. And we know that the kidney is where sodium is highly concentrated. So the working hypothesis in the lab is that these immune cells can be activated wherever they are, in the lymph nodes or not, in other tissues, but they can travel to the kidney.   We find that in high salt, if you feed high salt to the mouse, the endothelium in the kidney becomes dysfunctional and it expresses molecules, chemoattractants, that attract these immune cells in the kidney. We think that the high salt accumulation in the kidney can activate these, and then these immune cells are activated and they produce cytokines. Dr Steve Crowley showed that they can produce IL-1 beta, which induces activation of sodium channels that can be induced. We have also actually found that even IL-17 can be produced by these immune cells in the kidney and they can activate sodium channels in the kidney, leading retention of sodium and water and hypertension.   Cindy St. Hilaire:        Very cool. You used a lot of mice in this paper. Can you tell us, I just want to know a little bit about the models you chose to use, but also how similar is hypertension in mouse and humans? Obviously for atherosclerosis, we have to do lots of things to get them to form a plaque. Is hypertension similar in a mouse and do mice also show this salt-sensitive phenotype?   Annet Kirabo:             That is an extremely important point. If you read our paper, we use a slightly different approach. Most people do benchside to bed approach. We did the opposite. We did a bed to benchside approach.   Cindy St. Hilaire:        Always smart.   Annet Kirabo:             Yeah. We first started humans, and then with some references, we went to the mice, because I think when it comes to salt-sensitive blood pressure, mice are different from humans. In fact, if we look in the lab, we find that female mice are protected from salt-sensitive blood pressure, but we find that in the humans, it's the opposite. Females are more prone to salt-sensitive hypertension. Those are studies that we are doing right now. We haven't published. But we know that it can be different.   The model we use most of the time in the lab, the C57 mice, are resistant to salt-sensitive hypertension. These C57 mice would rather die before they raise their blood pressure in response to salt. We can induce salt-sensitivity in these mice like in the paper that we are discussing. When we induce the endothelial dysfunction using L-NAME and we wash it out, then these mice, when you give them, subsequently, salt, suggests that they become salt-sensitive. But we also have a salt-sensitive mouse model that we use, the 129/SV mouse. So we use several models to kind of prove the same thing over and over again with the findings that we found in humans.   Cindy St. Hilaire:        And you used a technique, which I'm a little bit familiar with, but I'd like to hear, A, about it from you, but also your experience in using it, and that is CITE-seq. So, how does that work?   Ashley Pitzer:              That was with our human study where we actually had patients come in, who were hypertensive, took them off medication for 2 weeks. They come in, we get baseline samples, we give them a salt load on one day, and then the next day we completely salt deplete them.   Cindy St. Hilaire:        How much is a salt load? Like a Big Mac? What's a salt load?   Ashley Pitzer:              Yeah, it's pretty much just like eating Lays chips all day. It's a lot of salt. It's a very salty meal.   Annet Kirabo:             And then in addition, we also infuse saline too.   Cindy St. Hilaire:        Oh, wow.   Annet Kirabo:             Because these people, when they come into the hospital, some them have already eating high salt. This approach is to just maximize the whole system so that then when we sort deplete everybody, it's at the same level and it's just to unify the whole process. But sorry, Ashley, you go ahead.   Ashley Pitzer:              With the CITE-seq, we're able to take different patients on different days. So we take samples each day, and we can give each sample a barcode, basically. Give them a barcode, we can pool them all together, process them, and we can sequence their RNA, we can probe for a certain amount of protein expression as well. So then when we analyze, we can look at protein expression, so you get the translation and the transcription for each person on each day, and then you're able to compare. And so you get this huge picture and it's a lot of data.   Cindy St. Hilaire:        How long did it take you to sort through?   Ashley Pitzer:              Well, we have a statistician who does all of that, because my wheelhouse is here and it is on a different planet. So we have somebody who helps us with that who does an unbiased approach. And then once he does an analysis, gives us back what are the things that are changing the most, and one of those was IL-1 beta.   Annet Kirabo:             As you can see, our list is huge, this is a massive input of so many collaborators. We have computational people on there that help us with this. I can't even begin to learn these techniques, but with all this collaboration and the resources at Vanderbilt, these things are possible. And so, this is a really powerful approach where you can combine protein expression and you get the specific cells that express the genes and you couple the channel type to the gene expression.   Annet Kirabo:             We actually found that not all monocytes are the same. There's a specific class that of monocytes, A small class of monocytes that is so angry, and the inflammasome is activated and producing this IL-1 beta, and that is enough to contribute to this phenotype of salt-sensitive hypertension, which dynamically changed according to blood pressure, suggesting that this is a targetable salt-sensitive blood pressure, even in normotensive people, is a targetable trait. And because these monocytes are in blood, can we get a blood sample and routinely diagnose salt-sensitive blood pressure so that doctors are aware and they can appropriately advise patients.   Cindy St. Hilaire:        This was samples obviously taken from a blood draw, right? So they're circulating.   Annet Kirabo:             It was a blood draw, yes.   Cindy St. Hilaire:        What do you think about these immune cells, perhaps, native in the kidney? Do you think the small population of angry cells, like you said, is escaping from the kidney environment? What do you think?   Annet Kirabo:             When I was a post-doc in David Harrison's lab, we found that the most angry dendritic cells that contribute to this inflammation and hypertension are monocyte-derived. So that's why in the human study we focused on monocytes, because there are so many subtypes of dendritic cells, plasmacytoid dendritic, classical dendritic cells. We have studied all of these subtypes, and we have focused on monocyte-derived dendritic cells because they're the ones that seem to be contributing to this phenotype the most.                                     Cindy St. Hilaire:        You guys focused in on the NLRP3 inflammasome, which, obviously it's a really critical component broadly for the innate immune system. Do you think that this is going to be a targetable approach that can be leveraged for hypertension? Or do you think it's too broad? What do you think about that as a therapeutic potential?   Ashley Pitzer:              Even when you look in our paper, and we use a knockout model, where we use a completely global knockout model, put them on high salt, and we give them back only dendritic cells that are from wild-type mice, so they have that NLRP3, that have been exposed to high salt. We were able to increase blood pressure, but I also did, in mice, where I gave them an IL-1 beta neutralizing antibody, similar to canakinumab, which is the CANTOS trial, and there's not much of a difference. There is, but it's minor. It's very minor.   Ashley Pitzer:              So, to be able to target in specific cell types in humans one thing, it's very difficult, and maybe one day we can get there. But I think it at least gives us a better idea of what is the full picture, what's the big mechanism going on with immune cells? In part of our human study, we are looking at something to try and be able to identify who is salt sensitive. So if anything, we're able to sit here and potentially have a way of identifying salt-sensitive patients, where, right now, all we can do is have them come in like we do and do a 3-day study, and not everybody can do that.   Annet Kirabo:             To add onto that, perhaps you know, we are talking about precision medicine. This is an era of precision medicine where you need to really tailor treatments if we can get there, and I think this is one way. CANTOS trial. They had no way of knowing who is salt-sensitive and who is not, it was a global approach, and the lack of differences in blood pressure might be explained that this IL-1 beta pathway is targetable in a specific population whose blood pressure is probably driven by inflammation. There are so many, many mechanisms that drive hypertension, and so perhaps we need to focus this on salt-sensitive people, and maybe we can really use this approach to target. Plus, this is ENaC-dependent.   As you know, amiloride has lost favor in the clinic as a treatment of hypertension, because in the majority, it's not effective. But studies have shown that in Black men, for example, who had been categorized salt-resistant, when they give them amiloride, their blood pressure went down, and yet it's not effective in the majority of the people.   So, can we bring back, can we take another look at amiloride. As our studies indicate that blockade of ENaC is anti-inflammatory and it's also antioxidant agent, can we at least bring back amiloride and look at it again and we focus it for specific populations of people that may be more prone to salt-sensitive hypertension?   Here we have so many targets for potential precision treatment of salt-sensitive potential in this paper. You can target SGK1, which we know is possible, we listed a number of clinical trials that they have used NLRP3 inflammasome inhibitors, you can use amiloride for these people, and you can also potentially scavenge IsoLGs.     Cindy St. Hilaire:        What was the most challenging aspect of this study? There's a lot of moving parts, so what was the biggest challenge? And then, also, what was the most surprising part or the most pleasantly surprising part?   Ashley Pitzer:              You have to think, most of this was going on right when the pandemic hit. And right before that, we had started our human recruitment for the human study. And so that put a little bit of a time damper on it.   Ashley Pitzer:              Other than that, it was just, we were finding one thing, developing a new experiment, doing it again, doing it again. And honestly, what was the most surprising and rewarding was just seeing the same thing in, because we took just PBMCs from normotensive patients, treated them with high salt, and saw the changes that we did with the inflammasome. And to see that exactly again in an in vivo model of giving patients high salt and seeing the same thing, it was very rewarding and confirmed that, okay, we're on the right path. Seeing the same thing over and over and over again, it kind of reaffirms that you had a good idea.   Annet Kirabo:             I might add, one of the most challenging was, initially, the computational. Oh, part of the pandemic I was, the pandemic hit, I had a baby during the pandemic, and it was my time to leave my home, and then all these things were going on. We had a clinical trial where patients had to come in. Vanderbilt was so super supportive ,even checking for COVID-19. Our patients could not have COVID-19. We needed to check them.   Cindy St. Hilaire:        Yeah.   Annet Kirabo:             They also had to check for COVID-19. And so during that time, I realized, wait, I need learn computation analysis. I realized I cannot learn, and then reached out to collaborators that helped. That was extremely challenging. And then the other challenging thing that we faced later during the pandemic is vaccinations. In our criteria, these people cannot be vaccinated for reasons. We've studied inflammation, hypertension, and so vaccination was confounding. And even COVID-19 is even more for confounding. So we had this exclusion criteria where we could not recruit anyone.   Annet Kirabo:             Everybody was having COVID, everybody was being vaccinated, and everybody was in that exclusion criteria, so it was difficult to get people. We have had some slow down, but right now it's beginning to build up.   Cindy St. Hilaire:        So, what's next? What's the next question?   Annet Kirabo:             We have so many.   Cindy St. Hilaire:        That means it was a great study. If you have more, that means it was a great study.   Annet Kirabo:             Yeah. This study and us, it kind of warms. The inside seat just opened up, we have primary data in the genetic regulation of ENaC, we have primary data where we found. We are trying to figure out the specific ENaC channel in these antigen-presenting cells. We don't know. We found that ENaC delta, for example, it's not found in a kidney or you talked about a kidney contribution versus immune cells. ENaC delta is not found in the kidney, but we have primary data that show that ENaC delta is the most correlated with cardiovascular risk, is the most correlated with kidney disease and all forms of hypertension. So now we're like, ENaC delta expressed in the immune cells, not in the kidney, it is the one that is most involved in cardiovascular disease, so how are we going to tell the world that.   Cindy St. Hilaire:        Yeah, very cool.   Annet Kirabo:             Those cells, not necessarily the kidney. The kidney plays a part because the cells are going there, but it's very, very exciting. Plus a number of other lines that we are investigating.   Cindy St. Hilaire:        It's great. Well, congratulations, again, on this publication, on just getting all this done with what sounds like extremely difficult patient recruitment. So, Dr Kirabo and Dr Pitzer, thank you so much for joining me today and I'm looking forward to these next studies on maybe ENaC delta.   Annet Kirabo:             Thank you. Thank you so much.   Ashley Pitzer:              Thank you for having us.   Cindy St. Hilaire:        That's it for the highlights from the August 5th and August 19th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and hashtag Discover CircRes. Thank you to our guests, Dr Annet Kirabo and Dr Ashley Pitzer.   This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022. Opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.  

Unsafe Space
[Episode 0835] [Narrative Dissonance] Twitch Bans Some B*tch

Unsafe Space

Play Episode Listen Later Aug 16, 2022 156:08


Carter and Juliet are joined by Alex Miceli and L (SomeBitchIKnow). L begins with a revealing discussion about her most recent ban: Twitch banned her due to her off-platform activity (in other words, because they disagree with her). Alex then talks about the recent attack on Salman Rushdie before the group turns to revelations about the FBI's disturbing level of involvement in the plot to kidnap governor Whitmer. Next up is a chat about carbon footprints and apocalyptic climate change predications. L and Alex dish out some diet and health advice, and a member of chat asks about dealing with corporate woke culture. With help from a balding male, an Irish "LGBTQ+ Inclusive" rugby team easily wins the women's 2022 Junior J Shield Final, which sets Twitter ablaze with calls to ban more "TERFs." Finally, the episode concludes with a rather blunt discussion of psychological dysfunction in modern women and the failure of men to notice. Alex Miceli is the host of 451 Degrees on Unsafe Space, as well as the creator behind the Alex of All Trades YouTube channel for gamers. You can find her gaming channel here: https://www.youtube.com/c/AlexofAllTrades-Miceli And all of her 451 Degrees content here on Unsafe Space. In addition, you can follow her on Twitter at: @AlexofAllGames L, .a.k.a. SomeBitchIKnow. is the relentless researcher behind SomeBitchMedia and the personification of its tagline: ”Cite your sources or GTFO.” She's helped explode mainstream narratives around the COOF, The 2020 Election, Jeffrey Epstein & Ghislaine Maxwell, and other issues. Find her on the web at: SomeBitchToldMe.com And on Gab at: @SomeBitchIKnow The video version of this episode is available here: https://unsafespace.com/ep0835 Links Referenced in the Show: Unsealed Trump warrant: https://apps.npr.org/documents/document.html?id=22131380-trump-warrant-uns A dude beats some young women at rugby: https://reduxx.info/irish-lgbtq-inclusive-football-team-with-transgender-player-wins-womens-junior-final/ About Narrative Dissonance "Narrative Dissonance" is a weekly series dedicated to shattering the narrative of the mainstream press. Each week, a team of panelists from alternative media sources unravel the latest misleading mainstream narratives and explore relevant stories that journalists in the corporate press ought to be covering, but aren't. Thanks for Watching! The best way to follow Unsafe Space, no matter which platforms ban us, is to visit: https://unsafespace.com While we're still allowed on YouTube, please don't forget to verify that you're subscribed, and to like and share this episode. You can find us there at: https://unsafespace.com/channel For episode clips, visit: https://unsafespace.com/clips Other video platforms on which our content can be found include: LBRY: https://lbry.tv/@unsafe BitChute: https://www.bitchute.com/channel/unsafespace/ Also, come join our community of dangerous thinkers at the following social media sites...at least until we get banned: Censorship-averse platforms: Gab: @unsafe Minds: @unsafe Locals: unsafespace.locals.com Parler: @unsafespace Telegram Chat: https://t.me/joinchat/H4OUclXTz4xwF9EapZekPg Censorship-happy platforms: Twitter: @_unsafespace Facebook: https://www.facebook.com/unsafepage Instagram: @_unsafespace MeWe: https://mewe.com/p/unsafespace Support the content that you consume by visiting: https://unsafespace.com/donate Finally, don't forget to announce your status as a wrong-thinker with some Unsafe Space merch, available at: https://unsafespace.com/shop

The Ben Maller Show
Hour 4 - Satisfied

The Ben Maller Show

Play Episode Listen Later Aug 16, 2022 36:43


Ben Maller talks about Patrick Mahomes telling the media that he is satisfied with his contract and values his legacy over being the highest-paid QB, Cite the Bite, and much more!See omnystudio.com/listener for privacy information.

City Cast Houston
50 Years of Downtown HTX's Growth Spurts

City Cast Houston

Play Episode Listen Later Aug 16, 2022 25:03


Houston is changing before our eyes — and nowhere more than downtown. Joining host Lisa Gray to discuss the radically different approaches architects have taken over the last 50 years are Stephanie Burritt, co-managing director of the architecture firm Gensler's Houston office; and Raj Mankad, the Houston Chronicle's op-Ed editor and a former managing editor of Cite, the magazine of the Rice Design Alliance. On the hunt for more Houston news? Then sign up for our morning newsletter here. We're also on social media! Follow us on Twitter and Instagram  Have thoughts or feelings about this episode? We'd love to hear from you! leave us a voicemail or text us at +1 713-489-6972 Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

The Ben Maller Show
Hour 4 - Silver & Black Spin

The Ben Maller Show

Play Episode Listen Later Aug 9, 2022 40:12


Ben Maller talks about Raiders head coach Josh McDaniels saying that the Raiders have no desire to trade Josh Jacobs and what the future really holds for the talented RB, Cite the Bite, and much more!See omnystudio.com/listener for privacy information.

The Ben Maller Show
Hour 4 - No Remorse

The Ben Maller Show

Play Episode Listen Later Aug 2, 2022 37:31


Ben Maller continues to dive into the Deshaun Watson ruling and discusses if Watson actually feels remorseful over what he did and how he was able to catch a break, Cite the Byte, and more!See omnystudio.com/listener for privacy information.