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In today's episode, host Dr. Amanda Redfern invites Dr. Nancy Newman to share updates in the treatment of Leber hereditary optic neuropathy (LHON), covering several clinical trials underway that involve idebenone and gene therapy. For all episodes or to claim CME credit for selected episodes, visit www.aao.org/podcasts.
Dive into the Horror: Scary Spirits Podcast Reviews "Hereditary" (2018) This week on the Scary Spirits podcast, we're thrilled to fulfill a listener's request! Join hosts Karen and Greg as they delve into the chilling depths of the 2018 horror masterpiece, Hereditary. A coworker of Greg's has specifically asked for this spine-tingling review, and we're excited to deliver! Hereditary, directed by Ari Aster, has been hailed as one of the most terrifying films of the decade. Karen and Greg will dissect the film's eerie plot twists, unforgettable performances, and haunting visuals. They'll explore the intricate storytelling that has left audiences around the world in shock and awe. From the unsettling family dynamics to the shocking climax, no stone will be left unturned in this comprehensive review. But that's not all! As always, our hosts will be enjoying a themed cocktail to enhance the experience. This week's drink is the "King of Demons" cocktail, inspired by the dark and mysterious elements of the film. Karen and Greg will share the recipe and their thoughts on how this devilishly delicious drink pairs with the movie's intense atmosphere. Whether you're a horror aficionado or a casual viewer, this episode promises to be a thrilling ride. You'll gain new insights into Hereditary and perhaps discover details you missed on your first viewing. Plus, the engaging banter between Karen and Greg will keep you entertained from start to finish. Subscribe now and join the conversation on the Scary Spirits podcast—where horror meets happy hour! Don't forget to leave your comments and let us know what you think of the film and the cocktail. We love hearing from our listeners and can't wait to share this spooky adventure with you!
In the final episode of this four-part series, Dr. Justin Abbatemarco and Dr. Nancy Newman discuss the abstract she presented at the AAN Annual Meeting and details on the upcoming gene therapy trial. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000208987
Programing Note: Busy Season is over! Episodes will be posted weekly for the time being as an apology for the month-ish off!Can Brenden's English theatre piece (The Lion in Winter) stand a chance against Ryan's elevated horror darling (Hereditary)?
In this episode, we review the high-yield topic of Hereditary Angioedema from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In part two of this four-part series, Dr. Justin Abbatemarco and Dr. Nancy Newman discuss current treatment options for Leber hereditary optic neuropathy (LHON). Show reference: https://index.mirasmart.com/AAN2025/PDFfiles/AAN2025-002206.html
In part two of this four-part series, Dr. Justin Abbatemarco and Dr. Nancy Newman discuss current treatment options for Leber hereditary optic neuropathy (LHON). Show reference: https://index.mirasmart.com/AAN2025/PDFfiles/AAN2025-002206.html
Dyslexia is hereditary and often doesn't skip generations. The speaker shares their personal journey of discovering their own dyslexia and later realizing their father, unknowingly dyslexic, had struggled with similar challenges. Traits once misunderstood—like blunt speech, social withdrawal, and avoidance behaviors—were actually linked to dyslexia. This newfound understanding strengthened their relationship and provided clarity.TakeawaysDyslexia is Hereditary – It often runs in families and typically doesn't skip generations.Late Diagnosis is Common – Many adults, like the speaker's father, may be dyslexic without realizing it.Misunderstood Traits – Social struggles, blunt speech, and avoidance behaviors can stem from dyslexia.Awareness Improves Relationships – Understanding dyslexia can foster empathy and better connections with loved ones.Self-Discovery is Important – Listeners are encouraged to explore their family history and seek resources for better understanding.KeywordsDyslexia, Hereditary, Family history, Late diagnosis, Social challenges, Misunderstood traits, Self-awareness, Empathy, Neurodiversity, Dyslexia resources, ADHD, adults with dyslexia.If you want to find out more visit:truthaboutdyslexia.comJoin our Facebook Groupfacebook.com/groups/adultdyslexia
In this episode of Horror Joy, Jeff and Brian delve into cult representations in Ari Aster's popular horror films 'Hereditary' (2018) and 'Midsommar' (2019). They emphasize the intricate storytelling and thematic parallels between the two films, providing in-depth analysis on toxic masculinity, folklore, and community care as portrayed in Aster's works.They discuss:· The nature of cult horror· Family dynamics· The supposed safe space of the home· The psychological exploration of grief and trauma within these narratives· the unsettling allure of cults and how these films reflect broader societal issues.· Toxic masculinity and horrorSo, grab your favorite tunic and ceremonial candle, and make sure to listen for the faint click of a tongue. But don't get left behind, lest you get sacrificed and left to the cycles of bloom and harvest for which we give thanks to our deity of reciprocity.Cary Elza, "'Do You Feel Held?': Gender, Community, and Affective Design in Midsommar."Aviva Briefel. "The Terror of Very Small Worlds: Hereditary and the Miniature Scales of Horror."Stacey Anh Baran. "‘Once upon a Midsommar…': Nature, nationalism and the Swedish folkloresque."Robert Pogue Harrison. The Dominion of the Dead.M. Night Shyamalan. The Village. 2004.Robin Hardy. The Wickerman. 1973.03:06 Deep Dive into Hereditary27:09 Introduction to Midsommar52:44 Finding Joy in Horror Films
Welcome to the Savage Horror Creeps Podcast! We are guides through the world of horror films past, present, and future! Narrating years, decades, sub-genres, subjects, and themes with honest reviews and rankings, no film (or listener) will be spared! The Savage Horror Creeps are back with an episode that covers some GREAT horror from the year 2018! Discover some hidden sci-fi horror gems through a year FULL of great horror, soundtracks, and gore! BUT FIRST, the creeps fend off a peanut allergy to tell you what they thought of Death of a Unicorn, The Woman in the Yard, and MORE! Special Shout-outs to Listeners Tak and Keri for reaching out!!! Episode 52: Savage Top Ten Hereditary Mandy Lords of Chaos Suspiria Halloween Strangers: Prey at Night A Quiet Place Annihilation The House That Jack Built Upgrade with Honorable Mentions, Horror Awards and nominees, and MORE! Be sure to subscribe to the Savage Horror Creeps Podcast on: Apple Spotify Or wherever you listen And dont forget to rate/review the podcast! It really helps out the show! You can email our show at savagehorrorcreeps@gmail.com and interact with us on: Instagram: @savagehorrorcreeps Facebook: The Savage Horror Creeps Podcast Page Stay tuned for our next episode, Episode 53: The Psycho Franchise!
What do Hereditary, Sound of Metal, A Ghost Story, and The Rugrats Movie have in common? They'll absolutely destroy you—and maybe help you feel a little more human while they're at it. This week, Jeremie and Brian sit down with Elliott and Kylie from the Moody Movie Club podcast, who are running a film screening series all about grief, loss, and those beautiful moments where a cartoon baby can make you ugly cry. Together, they unpack four films that hit like a truck and make a strong case for why sad movies might be better than therapy (not medical advice, obviously). From demonic moms to haunted pie-eating ghosts to the sound of silence (literally) to a baby's search for his mom—this episode is for anyone who's ever sobbed into their popcorn and said, “Damn, I needed that.”Learn more about the Moody Movie Club grief screening series here ➡ https://metrocinema.org/series/undone-by-each-other-grief-loss-and-mourning/Be sure to catch the full video version of this episode on YouTube!Follow Sickboy: Instagram: https://www.instagram.com/sickboypodcastTiktok: https://www.tiktok.com/@sickboypodcastDiscord: https://discord.gg/expeUDN
In part one of this four-part series, Dr. Justin Abbatemarco and Dr. Nancy Newman discuss how Leber hereditary optic neuropathy (LHON) typically presents and outline the steps for diagnosing LHON in a clinical setting. Show reference: https://index.mirasmart.com/AAN2025/PDFfiles/AAN2025-002206.html
What do Hereditary, Sound of Metal, A Ghost Story, and The Rugrats Movie have in common? They'll absolutely destroy you—and maybe help you feel a little more human while they're at it. This week, Jeremie and Brian sit down with Elliott and Kylie from the Moody Movie Club podcast, who are running a film screening series all about grief, loss, and those beautiful moments where a cartoon baby can make you ugly cry. Together, they unpack four films that hit like a truck and make a strong case for why sad movies might be better than therapy (not medical advice, obviously). From demonic moms to haunted pie-eating ghosts to the sound of silence (literally) to a baby's search for his mom—this episode is for anyone who's ever sobbed into their popcorn and said, “Damn, I needed that.”Learn more about the Moody Movie Club grief screening series here ➡ https://metrocinema.org/series/undone-by-each-other-grief-loss-and-mourning/Be sure to catch the full video version of this episode on YouTube!Follow Sickboy: Instagram: https://www.instagram.com/sickboypodcastTiktok: https://www.tiktok.com/@sickboypodcastDiscord: https://discord.gg/expeUDN
In this episode of Merco Movie Guys, Chad and Clint are joined by special guest Noah Louck, an expert in all things A24, to dive deep into the world of A24's chilling horror films! From cult classics like Hereditary and The Witch to under-the-radar gems, we share our personal favorites and discuss what makes A24's approach to horror so unique. We also break down the buzz surrounding the studio's latest release, Heretic, and give our thoughts on whether it lives up to the hype.
Artificially Intelligent girlfriends. Sarah Watt, Jeremy Downing and William Chen discuss Companion (2025) and Her (2013). Both films have director-writers in Drew Hancock and Spike Jonze, respectively. We start by discussing the vision of the future Her presents and how much has come to pass - 'prescient' is the word we all describe the film as. We celebrate a number of elements of Her that we enjoy. The conversation then moves to a discussion of Companion and how we found the film not as complex as Her. We discuss the films in connection to Lost In Translation (2003), Barbarian (2022), Ex Machina (2014), M3GAN (2022), Hereditary (2018), Midsommar (2019), Beau Is Afraid (2023), Heretic (2024), The White Lotus (2021-) and Yellowjackets (2021-). We praise the performances of Joaquin Phoenix, Amy Adams, Sophie Thatcher and Jack Quaid. We end with a discussion about real-world AI today and how the films connect to matters at hand.
Hello and thank you for downloading another episode of The Flixters Podcast! On this week's episode we discuss the latest release from hitmakers, A24. This is the studio that brought us Oscar winning Everything, Everywhere All At Once, or horror classic Hereditary. These guys know a thing or two about being off kilter, and dare we say it, edgy? Sometimes the mix is hard to get right but if a film studio can do it, it's them. Opus, their latest offering, starring the wonderful Ayo Edibiri (The Bear) and Hollywood veteran John Malkovich, comes across as a comedy but beneath the veneer lies a dark psychological twist. Does that twist pay off? Check out the show for more deets! And if you've seen the film hit us up on our YouTube channel and let us know your thoughts. On Anniversary Corner we look back at Colonia (2015)And if that's not enough entertainment for you, we've even thrown in new trailers to watch and what you can catch on streaming. Thank you for supporting us and we hope you enjoy the show! 00:00 Intro 02:10 Shoutouts04:51 Movie News16:30 New on Streaming21:09 New Trailers24:27 Anniversary Corner28:10 Mickey 17 Review41:50 OutroThis episode is proudly sponsored by Zencastr. Create your podcast today! #madeonzencastr
Philip's journey with ATTR began with unexplained weight loss and gastrointestinal issues that puzzled doctors for years. Despite seeing multiple specialists, his condition remained undiagnosed until a physician at Johns Hopkins finally connected the dots, confirming ATTR. By then, Philip had lost 60 pounds and was on the brink of survival. In today's episode of On Rare, David Rintell, Head of Patient Advocacy at BridgeBio, and Mandy Rohrig, Senior Director of Patient Advocacy at BridgeBio Gene Therapy, speak with Philip and his wife, Sally, who has helped to navigate the frustrating medical system, advocate for answers, and ultimately helped Philip receive life-saving IV nutrition. After years of uncertainty, Philip finally found an expert team with the knowledge, treatment, and community they needed. Philip and Sally share their story of perseverance, partnership, and hope for a brighter future. Dr. Adam Castaño, head of the Amyloid Prevention Program at BridgeBio, provides a medical overview of TTR amyloidosis (ATTR), a rare, progressive disease caused by misfolded transthyretin (TTR) proteins that form amyloid deposits in different parts of the body such as the heart, the peripheral nervous system, and the gastrointestinal tract. These deposits lead to debilitating symptoms including heart failure, neuropathy, and digestive issues, often mimicking common age-related conditions and possibly contributing to underdiagnosis. ATTR can be hereditary, but it also develops in the general population (this is called wild type). Advancements in non-invasive imaging and specialized protein staining have improved early detection, offering hope for better disease management.
This week Hannah suggests a double date, slags off Hereditary (spoilers if you ain't seen it), and Big Suze tells us about her Six The Musical celeb moment. BUT LET'S GET TO THE SPOOKY STORIES!It's another Creep of the Week special. There's just too many haunted huns, so we're delving right on in! Story 1 - from B narrated by Hannah. Mum, Dad and new baby go to Loch Lomond in the Scottish Highlands to a haunted hotel... Story 2 - from M narrated by Big Suze, from a NZ-based hun about being a nurse on a spinal injury unit in England... And ofc a demonic spirit. Story 3 - from Cerys read by Hannah - a normal terraced house with the kids.. or is it... think toy boxes being thrown and figures in the window.Story 4 - from Adam narrated by Big S. Tales of mimicing loved ones in the house... Story 5 - from Anna read by Hannah - a creepy holiday home in Spain.Story 6 - from Becca narrated by BIG S, we hear about late Gma Betty - a truly heartwarming story to end the eppy.Ty for all stories pls keep them coming, we love all you haunted huns loads!xoxoJOIN OUR PATREON! EXTRA bonus episodes AND a monthly ghost hunt for just £4.50! Or £6 for AD-FREE EPS and weekly AGONY HUNS! We'll solve your problems huns! Sign up here:www.patreon.com/GhostHuns
In this episode of The Road to Genome, we interview Rebecca Middleton at Leicester Royal Infirmary. Rebecca talks to us about her experience as a patient with a hereditary brain aneurysm, through the diagnosis and treatment, and the rollercoaster of emotions this brings. She also tells us about Hereditary Brain Aneurysm Support, an organisation Rebecca set up to support and inform people living with familial brain aneurysms and raise awareness of the condition as a rare disease, representing the lived experience and improving and saving lives.
Targeted, image-guided interventions can make a big difference for patients with hereditary hemorrhagic telangiectasia (HHT). Learn how in this week's BackTable episode featuring Dr. Clifford R. Weiss (Director of the Johns Hopkins Vascular Anomalies Center and HHT Center of Excellence) and host Dr. Michael Barraza. --- SYNPOSIS Dr. Weiss delves into the complexities and multisystem nature of HHT, emphasizing the significance of early diagnosis and multidisciplinary care. He goes on to explain the clinical criteria for diagnosing HHT, the role of genetic and imaging screenings, and the evolving approaches to treating pulmonary arteriovenous malformations (AVMs) in adults and children. The doctors discuss the potential impact of anti-angiogenic medications on the future management of HHT. The episode closes with a nod to the pivotal role that HHT Centers of Excellence play, and the ongoing dedication to improving patient outcomes through collaborative care and innovative research. --- TIMESTAMPS 00:00 - Introduction 03:57 - Diagnosing and Screening for Hereditary Hemorrhagic Telangiectasia (HHT) 07:37 - Treatment Approaches for HHT 12:12 - Embolization Techniques and Safety Measures 19:02 - Future of HHT Treatment and Research 22:30 - Conclusion and Final Thoughts --- RESOURCES The Johns Hopkins Hereditary Hemorrhagic Telangiectasia (HHT) Center of Excellence: https://www.hopkinsmedicine.org/interventional-radiology/hht
In episode fifty-seven, Caveman and Maggi hide in the treehouse to discuss Hereditary. Maggi finally has to watch it, but will she like it? Who doesn't know they are allergic to nuts? Why is a cult outside? LIGHT POLE!!!Follow our Instagram, Threads, & Letterboxd accounts @movieminglepod Check out our YouTube channel, MovieMinglePodcastQuestions? Comments? Write us at movieminglepod@gmail.com
I AM YOUR MOTHER! We continue Mommy March with the Ari Aster's iconic directorial debut HEREDITARY. Join Anneliese and I as we discuss this instant classic, the concept of elevated horror, and the mommy upon mommy issues in this film. Enjoy! Follow Would You Die? on IG @wouldyoudieshow Twitter @wouldyoudieshow Facebook @ Would You Die? Email wouldyoudiepodcast@gmail.com for business inquiries Follow Austin everywhere @austinmtorres Follow Anneliese everywhere @whimsiwillow Join us on Patreon! https://www.patreon.com/wouldyoudiepodcast Subscribe to our YouTube Channel! You can find my short films, Spooky Spotlight hosted by Deanna Hope, and much more! Visit the FANGORIA store: shop.fangoria.com/wouldyoudieshow Use Promo Code: WOULDYOUDIESHOW The Would You Die? Podcast can also be found on TikTok @wouldyoudiepodcast. Follow Austin on Letterboxd @torresau. Follow me on Bluesky @austinmtorres.bsky.social NEW Music is composed by Josie Palmer Podcast produced by Jeremy Lippitt Podcast graphics created by Crosshook Creative Watch my short film, The Blood Witch, here: https://www.youtube.com/watch?v=7Foz3PeQKJ4 Watch the trailer for my short film, Spider, here: https://youtu.be/r9lz_csWG8w?si=pbuCllGLZefI90oK Watch my short film, Ice Scream, here: https://youtu.be/tghxuuJjPxM Watch my short film, Best Day Ever, here: https://youtu.be/WDJbfRl2Qh4 Find Three Y's Men Media here! ThreeYsMenMedia.com
Double Tap Episode 401 This episode of Double Tap is brought to you by: Brownells, Black Rhino Concealment, Gideon Optics, XTech Tactical, Night Fision, and Mitchell Defense Welcome to Double Tap, episode 401! Your hosts tonight are Jeremy Pozderac, Aaron Krieger, Nick Lynch, and me Shawn Herrin, welcome to the show! XTech double your order giveaway. Best order comment gets their order doubled. Use discount code WLSISLIFE and add an order comment to be entered. - Dear WLS Dependable Don - Who wins Jermey or five hungry hobbits, in a bus? (No notes) Golden Teabag - Whats up guys, I done goofed and got drunk on gun broker. I won a .338 lapua and I need a scope for the thing. What would you recommend? #mondaysareformalort Alex P - Hey WLS crew, I am just getting into carry conceal I want to know your opinion on weapon mounted lights. I plan to get a black rhino concealment appendix holster, and I am contemplating whether or not I should include my weapons mounted light on it or not. In your opinion, what are the advantages and disadvantages of including a weapon mounted light on a daily carry gun? I have a Springfield XD Mod 2 in 9 mm and I currently have a streamlight mounted to it. Use case would be daily carrying mostly during the day to and from work with occasional use during evenings and weekends on outings and trips. Thanks for the support. Keep up the great work! Joseph J - 277 sig vs 7 backcountry. The high pressure 277. If a savage action will hold the 7bc won't it hold the 277? Looking at building a 277 for elk. Ian C - Hey shawn I want to get a thermal monocular. What makes one better than the other? I was looking at ATN and I have about $1,000 to spend. What would be the best option to buy? Anita New Aaron - Nick, Law Tactical makes an ARIC bolt carrier conversion kit so that you can fire the gun while folded. Is this dope or is Aaron a fuckface? No Notes Warrior of the Weekend - Sup fellas, I was listening to episode 598 and you guys mentioned that mental institutions should be brought back. Well, there was some really crazy reasons one could be admitted to a mental institution. Here's a condensed list from West Virginia circa October 22, 1864 to December 12, 1889. I'll provide a link to the source with all 125 reasons. I picked out a few that would guarantee you bastards (and myself) would have our own wing there Bad company Bad habits & political excitement Bad whiskey Deranged masturbation Disappointment Domestic trouble Egotism Feebleness of intellect Fell from horse Female disease Gastritis Greediness Gunshot wound Hereditary predisposition Immoral life Indigestion Kicked in the head by a horse Laziness Liver and social disease Masturbation & syphillis Masturbation for 30 years Mental excitement Moral sanity Parents were cousins Periodical fits Political excitement Remorse Self abuse Sexual abuse and stimulants Sexual derangement Snuff eating for two years Softening of the brain Tobacco & masturbation Trouble Venerial excesses Women trouble My question is, should we still have mental institutions? Have a blursed day! 125 reasons you'll get sent to the lunatic asylum - Appalachian History The winner of this week's swag pack is Anita New Aaron! To win your own, go to welikeshooting.com/dashboard and submit a question! Gun Industry News Affordable Glock Mag Upgrade for Steyr AUG Steyr launched a new AUG Glock magazine conversion kit at EnforceTac 2025, letting AUG owners use Glock 9mm magazines. This kit includes a new barrel, bolt, and magwell adapter and costs between €300-400. It's a significant upgrade for affordable 9mm use, and Steyr provides factory support for reliability. The product is currently available. New Schmidt & Bender Riflescope Debuts at IWA 2025 Schmidt & Bender launched the 3-18x42 Meta riflescope at IWA 2025. It has a slim design,
We did it! This is our Top 10 Favorite movies of the last 25 years with Alise Chaffins Get tasty meals delivered right to your door with FACTOR Meals factormeals.com/hallmarkies50off (sf) Check out Alise's book THE TED LASSO RELATIONSHIP GUIDE (ad) https://amzn.to/4dzR9y7 Follow Alise on instagram https://www.instagram.com/alisechaffins/ check out our new merch store with always low prices at https://hallmarkies.dashery.com/ Get our awesome Female Film Critics Speak Out logo at our merch store for all kinds of designs for mugs, masks, shirts and more https://www.teepublic.com/stores/hallmarkies?ref_id=8581 For all our Female Film Critics panels https://www.youtube.com/playlist?list=PL7wz447AgL4y6x38rcvZNfRlfYQUgWpDP Check out the Online Association of Female Film Critics https://oaffc.com/ Check out Cherry Picks https://www.thecherrypicks.com Please support my content on patreon at https://www.patreon.com/hallmarkies Listen to Hallmarkies Podcast at https://podcasts.apple.com/us/podcast/hallmarkies-podcast/id1296728288 Follow Rachel's Reviews on Itunes https://itunes.apple.com/us/podcast/rachels-reviews/id1278536301?mt=2 Follow Rachel's Reviews at https://rachelsreviews.net Follow Rachel on twitter https://twitter.com/rachel_reviews Follow Rachel on facebook https://www.facebook.com/smilingldsgirlreviews/ Find the patreon at https://www.patreon.com/hallmarkies Check out Hallmarkies Twitter at https://twitter.com/HallmarkiesPod Learn more about your ad choices. Visit megaphone.fm/adchoices
The 2010's were a great decade for horror with the emergence of prestige horror and larger budgets pushing studio projects to greater quality levels. We saw movies like Hereditary, Get Out, A Quiet Place, Let Me In, as well as the highest grossing horror movie of all time, It. Independent, smaller films thrived in this new environment and well-made and intelligent films became the standard. Jerry & Matt look at two diverse examples of great movies from this decade with Green Room from 2015 and The Conjuring 2 from 2016.
Mindframes – Episode 88: The Monkey (2025)
Hereditary Kidney Cancer Syndromes CME Available: https://auau.auanet.org/node/41772 ACKNOWLEDGEMENTS: Support provided by an independent educational grant from: Merck & Co., Inc. LEARNING OBJECTIVES: At the conclusion of this activity, participants should be able to: 1. Select patients who should undergo genetic testing to identify hereditary kidney cancer syndromes based on appropriate criteria, including family history and clinical presentation. 2. Implement strategies to address ethical concerns related to genetic testing, such as patient consent, confidentiality, and the potential impact on family members. 3. Discuss VHL syndrome, including its genetic basis, inheritance pattern, and associated tumors. 4. Properly diagnose and manage VHL syndrome in clinical practice based on knowledge of novel therapeutic strategies. 5. Utilize a multidisciplinary approach consisting of urologists, oncologists, geneticists and nephrologists when managing hereditary kidney cancer syndromes.
Hereditary angioedema (HAE) is a rare condition often due to reduced levels C1-inhibitor, which is a protein involved in various physiological processes in plasma, most notably with the complement system. C1-inhibitor also binds and inhibits plasma kallikrein and factor XIa, thereby affecting bradykinin production. It is believed that the disruptions of these processes cause fluid to leak from the blood to connective tissue, leading to HAE attacks. Owing to its rarity, HAE is often poorly recognized, leading to misdiagnoses and significant diagnostic delays. Being aware of the early signs and symptoms of this condition can lead to faster diagnosis and the use of effective therapies.This program is supported by independent medical education grants from Takeda. To earn CME credit please visit https://checkrare.com/learning/p-consider-rare-suspecting-and-diagnosing-hereditary-angioedema/lessons/consider-rare-suspecting-and-diagnosing-hereditary-angioedema-module/ Target AudienceThis activity has been designed to meet the educational needs of physicians specializing in primary care, pediatrics, emergency care, otolaryngology, gastroenterology, and dermatology .Other members of the care team may also participate.Learning ObjectivesAfter participating in the activity, learners should be better able to:- Describe the early symptoms of HAE and its clinical relevance.- Apply best practices to diagnose HAE more efficiently to reduce diagnostic delays. Faculty Jonathan A Bernstein, MDProfessor of MedicineUniversity of Cincinnati Department of Internal MedicineDivision of Immunology, Allergy SectionPartner Advanced Allergy Services, LLCPartner Bernstein Clinical Research Center Disclosure StatementAccording to the disclosure policy of the Academy, all faculty, planning committee members, editors, managers and other individuals who are in a position to control content are required to disclose any relationships with any ineligible company(ies). The existence of these relationships is not viewed as implying bias or decreasing the value of the activity. Clinical content has been reviewed for fair balance and scientific objectivity, and all of the relevant financial relationships listed for these individuals have been mitigated.Disclosure of relevant financial relationships are as follows:Dr. Bernstein discloses the following relevant financial relationships with ineligible companies:Advisory Board Consultant: Takeda/Shire, CSL Behring, KalVista, Pharming, Biocryst, Ionis, Intellia, Pharvaris, Astria and BiomarinGrant/Research Support: Takeda/Shire, CSL Behring, KalVista, Pharming, Biocryst, Ionis, Intellia, Pharvaris, Astria and BiomariSpeaker's Bureau: PharmingPlanners for this activity have no relevant financial relationships with any ineligible companies.This activity will review off-label or investigational information.The opinions expressed in this educational activity are those of the faculty, and do not represent those of the Academy or CheckRare CE. This activity is intended as a supplement to existing knowledge, published information, and practice guidelines. Learners should appraise the information presented critically, and draw conclusions only after careful consideration of all available scientific information.Accreditation and Credit DesignationIn support of improving patient care, this activity has been planned and implemented by American Academy of CME, Inc. and CheckRare CE. American Academy of CME, Inc. is Jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.PhysiciansAmerican Academy of CME, Inc., designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Other HCPsOther members of the care team will receive a certificate of participation.There are no fees to participate in the activity. Participants must review the activity information including the learning objectives and disclosure statements, as well as the content of the activity. To receive CME credit for your participation, please complete the pre and post-program assessments. Your certificate will be emailed to you within 30 days.ContactFor any questions, please contact: CEServices@academycme.orgCopyright© 2025. This CME-certified activity is held as copyrighted © by American Academy of CME and CheckRare CE. Through this notice, the Academy and CheckRare CE grant permission of its use for educational purposes only. These materials may not be used, in whole or in part, for any commercial purposes without prior permission in writing from the copyright owner(s).
Did you know you can specialize when you work in primary care? As a surgical PA, I've worked in various surgical subspecialities, but the concept of primary care subspecialities was brand new to me. My guest today, Alex Childs, shares his story of specializing in pharmacogenetics as a primary care PA. Alex is a PA with a Doctor of Medical Science degree working in family medicine in Utah. Alex's doctorate research focused on implementing genetic testing in primary care. In practice, he has done this with hereditary cancer risk testing and pharmacogenetic testing. In today's episode, Alex shares what he loves about working in primary care and gives actionable tips on how to thrive as a primary care provider. Alex also explained what the heck pharmacogenetics is and how he uses it to provide high quality care and early interventions with his patients. He also describes how he began working as an medical science liaison (MSL) in industry while still working as a family medicine PA. I think my favorite part of our discussion was talking about how every medical provider can get their joy back when it comes to practicing medicine. Press play to learn how to find your passion for medicine again if you've been feeling burned out. SPONSORSAAPA Job Source: aapa.org/pajobsourceFreed AI [DISCOUNT CODE: PA50] https://www.getfreed.aiREFERENCES1. Fred HL, Scheid MS. Physician burnout: causes, consequences, and (?) cures. Tex Heart Inst J. 2018;45(4):198-202. doi:10.14503/THIJ-18-68422. Samuel D. Who Are Medical Science Liaisons? THE MSL. March 27, 2020. Accessed February 3, 2025. https://themsljournal.com/article/who-are-medical-science-liaisons/3. Carrau D, Janis JE. Physician burnout: solutions for individuals and organizations. Plast Reconstr Surg Glob Open. 2021;9(2):e3418. doi:10.1097/GOX.0000000000003418CONNECT WITH ALEXLinkedIn: https://www.linkedin.com/in/alex-childs-565b4884COACHING1-ON-1 NEGOTIATION CONSULT https://calendly.com/the-pa-is-in/negotiate FREE 30-MINUTE COACHING CONSULT https://calendly.com/the-pa-is-in/gen-call LINKSTRACY ON INSTAGRAM https://www.instagram.com/mrstracybingaman/TRACY ON LINKEDIN https://www.linkedin.com/in/tracybingaman/SUPPORT THIS PODCAST: https://podcasters.spotify.com/pod/show/thepaisin/supportKeywords: Pharmacogenetic testing, Hereditary cancer risk testing, PA career growth, Primary care subspecialties, Doctor of Medical Science PA, Physician assistant career paths, PA industry jobs, PA professional development, Genetic testing in medicine, How to thrive as a primary care PA. Secondary keywords: Pharmacogenetic testing, Hereditary cancer risk testing, PA career growth, Primary care subspecialties, Doctor of Medical Science PA, Physician assistant career paths, PA industry jobs, PA professional development, Genetic testing in medicine, How to thrive as a primary care PALong-tail keywords: Can physician associates specialize in primary care?, How to implement genetic testing in primary care, Pharmacogenetics for primary care providers, What is a medical science liaison (MSL) in healthcare?, Career options for physician associates outside clinical practice, How PAs can work in both industry and clinical practice, Overcoming burnout as a primary care provider
"Even something as simple as a lava lamp can transform your creative space and unlock new ideas." - jacuzzi jeffersonThe Artist Behind the SoundMeet jacuzzi jefferson – not your average music producer.The Brooklyn-based creative force has carved a unique path where education meets sonic innovation. His distinctive blend of alternative hip-hop, electronic house, and lo-fi boom-bap hasn't just captivated listeners – it's earned him partnerships with industry giants like Harman Kardon & BMW.When he's not crafting beats, jacuzzi shapes the next generation of producers as a professor of Digital Music at Hostos Community College (CUNY). His engineering credits read like a who's who of the music industry: 50 Cent, Melanie Fiona, Juelz Santana, and Trey Songs.Crafting the Perfect Creative EnvironmentIn Part 2 of our conversation, jacuzzi opens up about the intimate details of his creative process – from his essential tools to the seemingly small touches that transform his workspace.
A happy, wholesome family podcast episode with a happy, wholesome, very family man with no father.Follow me on Instagram and Tik Tok:@lordblessthisjess
The ABMP Podcast | Speaking With the Massage & Bodywork Profession
For his 40th birthday, a man is treating himself to his very first massage. His health history includes a few noteworthy details, one of which is a condition neither his massage therapist nor I had ever encountered before: hereditary spherocytosis. Are there any potential concerns? Possibly. Resources: Hereditary Spherocytosis - Symptoms, Causes, Treatment | NORD (no date). Available at: https://rarediseases.org/rare-diseases/anemia-hereditary-spherocytic-hemolytic/ (Accessed: 19 February 2025). Hereditary spherocytosis: MedlinePlus Genetics (no date). Available at: https://medlineplus.gov/genetics/condition/hereditary-spherocytosis/ (Accessed: 19 February 2025). ‘Hereditary Spherocytosis: Practice Essentials, Pathophysiology, Etiology' (2023). Available at: https://emedicine.medscape.com/article/206107-overview?_gl=1*1ulm2jw*_gcl_au*NDQwNzg1MDc3LjE3MzkzMDYxNDM. (Accessed: 19 February 2025). Hereditary Spherocytosis: What It Is, Symptoms, Causes & Treatment (no date) Cleveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/23058-hereditary-spherocytosis (Accessed: 19 February 2025). Mehta, P. (no date) What Is Hereditary Spherocytosis?, WebMD. Available at: https://www.webmd.com/children/what-is-hereditary-spherocytosis (Accessed: 19 February 2025). Host Bio: Ruth Werner is a former massage therapist, a writer, and an NCBTMB-approved continuing education provider. She wrote A Massage Therapist's Guide to Pathology, now in its seventh edition, which is used in massage schools worldwide. Werner is also a long-time Massage & Bodywork columnist, most notably of the Pathology Perspectives column. Werner is also ABMP's partner on Pocket Pathology, a web-based app and quick reference program that puts key information for nearly 200 common pathologies at your fingertips. Werner's books are available at www.booksofdiscovery.com. And more information about her is available at www.ruthwerner.com. About our Sponsors: Anatomy Trains: www.anatomytrains.com American Massage Conference: https://www.massagetherapymedia.com/conferences Anatomy Trains is a global leader in online anatomy education and also provides in-classroom certification programs for structural integration in the US, Canada, Australia, Europe, Japan, and China, as well as fresh-tissue cadaver dissection labs and weekend courses. The work of Anatomy Trains originated with founder Tom Myers, who mapped the human body into 13 myofascial meridians in his original book, currently in its fourth edition and translated into 12 languages. The principles of Anatomy Trains are used by osteopaths, physical therapists, bodyworkers, massage therapists, personal trainers, yoga, Pilates, Gyrotonics, and other body-minded manual therapists and movement professionals. Anatomy Trains inspires these practitioners to work with holistic anatomy in treating system-wide patterns to provide improved client outcomes in terms of structure and function. Website: anatomytrains.com Email: info@anatomytrains.com Facebook: facebook.com/AnatomyTrains Instagram: www.instagram.com/anatomytrainsofficial YouTube: https://www.youtube.com/channel/UC2g6TOEFrX4b-CigknssKHA American Massage Conference Get ready to immerse yourself in the excitement as the American Massage Conference (AMC) arrives to Disney Springs near Orlando, Florida (May 16th-18th, 2025)! With a legacy of 17 successful years in Ontario, Canada, this premier event, proudly hosted by ONE Concept Conferences and expertly produced by Massage Therapy Media (MTM), boasts a lineup of presenters from across the nation and around the globe. The American Massage Conference began in Atlanta in 2011 and has been hosted through the years in San Diego, Chicago, and Virginia Beach. The conference provides educational opportunities with engaging one-, two-, three- and four-hour class formats, networking opportunities, masterminds, MTM Talks, demonstrations, and an extensive exhibitor tradeshow. Mark your calendars for an unforgettable experience filled with education, networking, and the celebration of massage therapy excellence! ABMP members receive a special discount to attend this in-person conference—log in to your ABMP account to access the discount code and register today. Website: https://www.massagetherapymedia.com/conferences
HELLO FELLOW SELF-LOVING HUMANS! Do we have a TREAT for you! After stalking his Instagram for YEARS, pre-ordering a signed copy of his book "DIY: The Wonderfully Weird History and Science of Masturbation" I had the absolute pleasure of sitting down with the incredible Dr. Eric Sprankle—a sex psychologist, author, and Associate Professor at Mankato State University—who just released his groundbreaking new book on masturbation and sexual health.
It's the end of season 48, which means it's time for an episode of THE BEST Movie Ever Made where the boys talk about Hereditary. We're doing something a little different this week because Rob is underwhelmed, Bob is neutral, and Chris wants to be tea-bagged by Paimon and gargle all of his demonic goo because he loves this movie so much.Is Hereditary the pinnacle of “elevated horror,” or is it patronizing poo-poo that undermines its own premise through its excessive use of foreshadowing? Tune in and find out! Dude decapitates dad's daughter and is damned to don a demonic deity derby! Family drama, or family trauma? Chomping on Chekhov's Nuts! Unsettling scenes and surrealist style! Unforced foreshadowing that informs and frightens! Undeserved decapitation of dad's daughter (again)! Undetermined direction daring you to define it, and much, much more on this week's episode of The BEST Movie Ever Made! www.theworstmovieevermade.com
On this very special episode, we are honored to be joined by I Will Never Leave You Alone writer/director DW Medoff. DW was kind enough to take time out of one of his rare days off to discuss the making of this film, as well as his upcoming project.After listening to this episode, we encourage you to check out I Will Never Leave You Alone and Pollen.2:56 - DW talks about wrapping his latest film10:17 - DW's origin story12:18 - Favorite films of 202417:11 - Hereditary hot take20:16 - Quickfire interview questions31:44 - DW's thoughts on horror-comedies40:47 - Big budget vs. small budget films44:14 - DW's experience at Telluride Film Festival49:56 - Plot synopsis (spoiler-free)51:12 - Bill's three predictions for this film52:54 - Content warnings56:40 - DW on the future of horror cinema1:01:10 - Grief and trauma in his films1:09:39 - Dark Fact of the Day straight from the set of I Will Never Leave You Alone1:13:24 - I Will Never Leave You Alone (spoilerific discussion)2:01:37 - DW on writing women2:12:38 - 'Maiden, Mother, Crone' - intentional archetypes or coincidence?2:18:45 - DW's sign-off2:20:23 - Rating I Will Never Leave You Alone2:24:10 - Stacie introduces our next seriesContent warning: We love horror and want everyone to enjoy it accessibly and safely. In general, assume we may talk about violence, gore, death, and scary situations. We provide a customized content warning about the movie for each episode during the episode, before launching into the plot. If you have particular triggers, please check the movie on doesthedogdie.com.
Between 5-10% of breast and 20-25% of ovarian cancers are inherited. The majority of hereditary breast and ovarian cancer cases are caused by deleterious mutations (variants) in the BRCA1 and BRCA2 genes, which normally prevent cancer through protecting and repairing our DNA. Genetic testing is used to identify pathogenic BRCA carriers who would subsequently benefit from personalized screening, preventative and management plans. However, its widespread implementation has resulted in a significant increase in findings of variants of uncertain significance (VUS) – DNA sequence variants with uncertain effects on disease risk. VUSs pose a critical clinical challenge as they limit clinicians' ability to effectively interpret genetic test results. For upcoming interviews check out the Grad Chat webpage on Queen’s University School of Graduate Studies & Postdoctoral Affairs website.
In this episode, we review the high-yield topic of Hereditary Spherocytosis from the Hematology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets
WE FUCKING LOVE YA
152. Constantine (2005) Hello Excellent Hellblazers! First off, a ☆ CONTENT WARNING ☆ This episode contains plot-necessitated discussion of self harm and suicide, and if that's not your thing, we understand. But if you're sticking around, you'll hear Allison & Hunter discuss a much maligned 2005 Vertigo comics adaptation. We discuss similarities with Hellboy (2004), the screenwriting concepts of the Big Buy-In and the Little Buy-In, and Papa Midnight's shelf full of haunted cymbal monkeys! PLUS: a plug for Hundreds of Beavers (make sure you see Hundreds of Beavers)! Get ready to visit the Electronic Dance Marianas and listen to plenty of Blubstep music with your pal Big Mouth Billy Bass Guitar, it's Constantine (2005)! Previous Episodes Mentioned: Ep. 26: Hereditary (2008) Ep. 121: La La Land (2016) Questions, comments, requests? Write us at: WriteHWGW@gmail.com
In this episode, Dr. Mark Cripe and I are joined by Dr. Kevin Hughes, the Director of Cancer Genetics at the Hollings Cancer Center and the McKoy Rose, Jr., M.D. Endowed Chair in Surgical Oncology in the College of Medicine at MUSC. Dr Hughes is recognized nationally and internationally for his expertise in breast cancer, breast disease management, genetic testing and the identification and management of patients with hereditary breast cancer risk. His research focuses on developing tools that make cancer genetic testing simple, safe, and efficient.https://hollingscancercenter.musc.edu/patient-care/genetic-counseling-and-hereditary-cancer/hereditary-cancer-clinichttps://web.musc.edu/inourdnascYou will learn:1. What is the definition of “High Risk”? 2. What are some risk factors for high risk? 3. Discuss the different risk calculators? Will AI replace these models? 4. How do you counsel woman at high risk? 5. Understanding many obstacles in seeing and counseling patients (socioeconomic, access to quality care, etc) do you think that we can use AI to help us?6. How does having a high risk (Hereditary cancer clinic) like the one you have benefit hospital systems? 7. Million-dollar question? Will AI replace physicians and surgeonsJ? Stay Connected with Dr. Deepa Halaharvi:TikTok: @breastdoctorInstagram: @drdhalaharviTBCP Instagram: @thebreastcancerpodcastWebsite: https://drdeepahalaharvi.com/YouTube: https://www.youtube.com/@deepahalaharvi5917Instagram: @thebreastcancerpodcast
Your Genetics are a key part of my TUSHY Method (Y = Your genetics) and I'm so honored to have Dena Goldberg (also known far and wide as Dena DNA) joining me today! Some of the questions I know you have on your mind about genetics are: Nothing came back on my 23 & Me test. I'm good to go, right? Answer: Not so fast. 23&Me relies on "SNP testing," and only looks at "very specific bookmarks on very random genes." You'll want a more thorough test for preconception screening. I don't have any history of disease in my family. Do I need to do genetic testing? Answer: It's a good idea. There are syndromes such as Lynch Syndrome that are asymptomatic in 90% of people who are carriers. You'll want to know if you have those genetic markers before passing them on to your embryo and child. Can you make sure my embryo doesn't have autism? Answer: Autism is actually a description of a constellation of symptoms. So it's not an underlying condition in and of itself. There are hundreds to thousands of genetic causes to autism. We can catch some of these cases, but not all. Autism is multifactorial, meaning that many of these cases are probably caused by a combination of genetics and environment or in other words, nature and nurture together. Thank you for joining me, Dena! Listen on Dr. Aimee's website Do you have questions about IVF? Join Dr. Aimee for The IVF Class at The Egg Whisperer School. The class includes a live class call where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom. The next call is Monday, February 10, 2025. Find Dena's site here: https://www.denadna.com/home Subscribe to my YouTube channel for more fertility tips! Join Egg Whisperer School Checkout the podcast Subscribe to the newsletter to get updates Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.
In this episode, we dive into the haunting world of Saint Maud, a slow-burn religious horror film that delivers big on atmosphere, dread, and a finale you won't forget. Join us as we break down the movie's powerful performances, its chilling exploration of faith and isolation, and how it stacks up to other psychological horror masterpieces like The Witch and Hereditary. We'll also talk about how Saint Maud compares to films like Immaculate, where religious themes and character-driven storytelling take center stage. Plus, we'll discuss our favorite moments, the stunning cinematography, and that unforgettable ending. If you're into movies that make you think and keep you on edge, this episode is for you!
Hereditary chief Bill Wilson, who helped to reshape Indigenous rights in Canada, has died. Matt Galloway discusses his legacy with his daughters, Kory Wilson, chair of the B.C. First Nations Justice Council; and Jody Wilson-Raybould, the former federal minister of justice.
This educational program is made possible by an unrestricted grant from Takeda Pharmaceuticals.Hereditary angioedema (HAE) is a rare genetic disease that results in immunologic attacks that can be life-threatening. HAE is the result of reduced levels of C1-inhibitor, a protein involved in various physiological processes in plasma, most notably with the complement system. C1-inhibitor also binds and inhibits plasma kallikrein and factor XIa, thereby affecting bradykinin production. It is believed that the disruptions of these processes lead to fluid leaking from the blood to connective tissue which leads to HAE attacks. It is these HAE attacks that tend to put persons in the emergency department or unable to attend work or school.Numerous therapies are now available for patients with HAE to both treat acute attacks and prevent attacks via prophylactic treatment.With so many treatment options now available, is it disheartening to learn that not all patients with HAE are receiving equal care or access to care. Patients with HAE living in rural areas as patients from underrepresented racial or ethnic backgrounds are not provided the same level of care as patients, especially Caucasian patients, living in more affluent areas. This panel discussion by three clinical research leaders in HAE, Drs. Aleena Banerji, Timothy Craig, and Marc Riedl, provide an overview of the discrepancies in care observed in certain patient populations, as well as a discussion on best practices to reduce those inequalities moving forward.To view this program in video format, go to https://checkrare.com/improving-health-equity-in-hereditary-angioedema-hae-a-panel-discussion/
Preview: Adrian Wooldridge Explores How Meritocratic Elites Historically Distrusted Both Popular Democracy and Hereditary Aristocracy, Favoring Rule by the Most Talented. More Later. 1845
Send Superchats at any time here: https://streamlabs.com/jaydyer/tip Get started with Bitcoin here: https://www.swanbitcoin.com/jaydyer/ The New Philosophy Course is here: https://marketplace.autonomyagora.com/philosophy101 Set up recurring Choq subscription with the discount code JAY44LIFE for 44% off now https://choq.com Lore coffee is here: https://www.patristicfaith.com/coffee/ Orders for the Red Book are here: https://jaysanalysis.com/product/the-red-book-essays-on-theology-philosophy-new-jay-dyer-book/ Subscribe to my site here: https://jaysanalysis.com/membership-account/membership-levels/ Follow me on R0kfin here: https://rokfin.com/jaydyerBecome a supporter of this podcast: https://www.spreaker.com/podcast/jay-sanalysis--1423846/support.
Welcome to Season 2 of the Orthobullets Podcast. Today's show is Core, where we review Core Knowledge for Orthopaedic Surgeons. This episode will cover the topic of Osteochondroma & Multiple Hereditary Exostosis, from our Pathology section at Orthobullets.com. Follow Orthobullets on Social Media: Facebook Instagram Twitter LinkedIn YouTube
A grieving Bill Simmons, Chris Ryan, and Sean Fennessey are haunted by tragic and disturbing occurrences in the podcast studio after rewatching Ari Aster's 2018 film, ‘Hereditary,' starring Toni Collette, Gabriel Byrne, Milly Shapiro, and Alex Wolff. Watch this episode on our Ringer Movies YouTube channel! Producer: Craig Horlbeck Learn more about your ad choices. Visit podcastchoices.com/adchoices