Podcasts about Pancreatic cancer

As we near the end of 2025, how was this year for you?  Personally?  Professionally? What was some of the biggest financial news in 2025? What are you looking forward to in 2026? As the year comes to an end, Shawn & George take a look back, and a small look forward at 2025 and 2026, including topics like: Mortgage / Interest Rates Grocery and Utility costs Government Shut Down Student Loan Adjustments Credit Card Debt Personal Guarantees Housing Market Let us know if you enjoy this episode and, if so, please share it with your friends! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt   To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach   To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com.  And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026 

This week we are talking about Pancreatic cancer.  This is a type of cancer that begins as a growth of cells in the pancreas. The pancreas lies behind the lower part of the stomach. It makes enzymes that help digest food and hormones that help manage blood sugar. The most common type of pancreatic cancer is pancreatic ductal adenocarcinoma. This type begins in the cells that line the ducts that carry digestive enzymes out of the pancreas. Pancreatic cancer rarely is found at its early stages when the chance of curing it is greatest. This is because it often doesn't cause symptoms until after it has spread to other organs. Your health care team considers the extent of your pancreatic cancer when creating your treatment plan. Treatment options may include surgery, chemotherapy, radiation therapy or a mix of these. Pancreatic cancer often doesn't cause symptoms until the disease is advanced. When they happen, signs and symptoms of pancreatic cancer may include: Belly pain that spreads to the sides or back. Loss of appetite. Weight loss. Yellowing of the skin and the whites of the eyes, called jaundice. Light-colored or floating stools. Dark-colored urine. Itching. New diagnosis of diabetes or diabetes that's getting harder to control. Pain and swelling in an arm or leg, which might be caused by a blood clot. Tiredness or weakness. It's not clear what causes pancreatic cancer. Doctors have found some factors that might raise the risk of this type of cancer. These include smoking and having a family history of pancreatic cancer. Understanding the pancreas The pancreas is about 6 inches (15 centimeters) long and looks something like a pear lying on its side. It releases hormones, including insulin. These hormones help the body process the sugar in the foods you eat. The pancreas also makes digestive juices to help the body digest food and take in nutrients. How pancreatic cancer forms Pancreatic cancer happens when cells in the pancreas develop changes in their DNA. A cell's DNA holds the instructions that tell a cell what to do. In healthy cells, the instructions tell the cells to grow and multiply at a set rate. The cells die at a set time. In cancer cells, the changes give different instructions. The changes tell the cancer cells to make many more cells quickly. Cancer cells can keep living when healthy cells would die. This causes there to be too many cells. The cancer cells might form a mass called a tumor. The tumor can grow to invade and destroy healthy body tissue. In time, cancer cells can break away and spread to other parts of the body. Most pancreatic cancer begins in the cells that line the ducts of the pancreas. This type of cancer is called pancreatic ductal adenocarcinoma or pancreatic exocrine cancer. Less often, cancer can form in the hormone-producing cells or the neuroendocrine cells of the pancreas. These types of cancer are called pancreatic neuroendocrine tumors or pancreatic endocrine cancer. Risk factors Factors that might raise the risk of pancreatic cancer include: Smoking. Type 2 diabetes. Chronic inflammation of the pancreas, called pancreatitis. Family history of DNA changes that can increase cancer risk. These include changes in the BRCA2 gene, Lynch syndrome and familial atypical multiple mole melanoma (FAMMM) syndrome. Family history of pancreatic cancer. Obesity. Older age. Most people with pancreatic cancer are over 65. Drinking a lot of alcohol. As pancreatic cancer progresses, it can cause complications such as: Weight loss. People with pancreatic cancer might lose weight as the cancer uses more of the body's energy. Nausea and vomiting caused by cancer treatments or a cancer pressing on the stomach might make it hard to eat. Sometimes the body has trouble getting nutrients from food because the pancreas isn't making enough digestive juices. Jaundice. Pancreatic cancer that blocks the liver's bile duct can cause jaundice. Signs include yellowing of the skin and the whites of the eyes. Jaundice can cause dark-colored urine and pale-colored stools. Jaundice often occurs without belly pain. If the bile duct is blocked, a plastic or metal tube called a stent can be put inside it. The stent helps hold the bile duct open. This is done using a procedure called endoscopic retrograde cholangiopancreatography, also called ERCP. During ERCP, a health care professional puts a long tube with a tiny camera, called an endoscope, down the throat. The tube goes through the stomach and into the upper part of the small intestine. The health professional puts a dye into the pancreatic ducts and bile ducts through a small tube that fits through the endoscope. The dye helps the ducts show up on imaging tests. The health professional uses those images to place a stent at the right spot in the duct to help hold it open. Pain. A growing tumor may press on nerves in your abdomen, causing pain that can become severe. Pain medications can help you feel more comfortable. Treatments, such as radiation and chemotherapy, might help slow tumor growth and provide some pain relief. When medicines aren't helping, a health care professional might suggest a celiac plexus block. This procedure uses a needle to put alcohol into the nerves that control pain in the belly. The alcohol stops the nerves from sending pain signals to the brain. Bowel blockage. Pancreatic cancer can grow into or press on the first part of the small intestine, called the duodenum. This can block the flow of digested food from the stomach into the intestines. A health care professional might suggest putting a tube called a stent in the small intestine to hold it open. Sometimes, it might help to have surgery to place a feeding tube. Or surgery can attach the stomach to a lower part of the intestines where the cancer isn't causing a blockage. Prevention Screening for people with a high risk of pancreatic cancer Screening uses tests to look for signs of pancreatic cancer in people who don't have symptoms. It might be an option if you have a very high risk of pancreatic cancer. Your risk might be high if you have a strong family history of pancreatic cancer or if you have an inherited DNA change that increases the risk of cancer. Pancreatic cancer screening might involve imaging tests, such as MRI and ultrasound. These tests are generally repeated every year. The goal of screening is to find pancreatic cancer when it's small and most likely to be cured. Research is ongoing, so it's not yet clear whether screening can lower the risk of dying of pancreatic cancer. There are risks to screening. This includes the chance of finding something that requires surgery but later turns out to not be cancer. Talk about the benefits and risks of pancreatic cancer screening with your health care team. Together you can decide whether screening is right for you. Genetic testing for cancer risk If you have a family history of pancreatic cancer, discuss it with a health care professional. The health professional can review your family history and help you understand whether genetic testing might be right for you. Genetic testing can find DNA changes that run in families and increase the risk of cancer. If you're interested in genetic testing, you might be referred to a genetic counselor or other health care professional trained in genetics. Ways to lower risk You might reduce your risk of pancreatic cancer if you: Stop smoking. If you smoke, talk to a member of your health care team about ways to help you stop. These might include support groups, medicines and nicotine replacement therapy. Maintain a healthy weight. If you are at a healthy weight, work to maintain it. If you need to lose weight, aim for a slow, steady weight loss of 1 to 2 pounds (0.5 to 1 kilogram) a week. To help you lose weight, exercise most days of the week. Slowly increase the amount of exercise you get. Choose a diet rich in vegetables, fruit and whole grains with smaller portions.  (CREDITS: MAYO CLINIC)

What can you learn about budgeting from Santa's Holiday preparation?   What lessons do the holiday bring? On this week's episode of The Crushing Debt Podcast, Shawn & George talk about: Overhead costs Supply chain issues Labor force issues North Pole budgeting Budgeting among multiple celebrations Gift-giving expectations Holiday season cash-flow We hope you had an amazing Thanksgiving break and a great holiday season. For Thanksgiving, it would mean a lot to us for you to please share this episode with your friends! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt   To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach   To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com. And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026 

Jon Fox, a 41-year-old Staten Island native, shares his unique and inspiring journey on this episode of the Project Purple Podcast with host Dino Verrelli. Jon's story begins unexpectedly at 37, when he was diagnosed with aggressive, metastatic testicular cancer: a diagnosis that would soon lead to the discovery of another, more unexpected health challenge: Stage 1 localized pancreatic cancer. Jon reflects on how the pancreatic tumor was found almost by accident during testing for his testicular cancer. Facing two serious medical battles at once, he underwent the Whipple procedure and a testicular cancer surgery simultaneously—a grueling combination that demanded resilience, patience, and determination. He candidly shares the brutal recovery that followed: months of intense complications, acute pancreatitis episodes, digestive struggles, and the ongoing challenge of learning how to live with a body transformed by surgery. Despite the hardships, Jon has channeled his experience into a passion for understanding the gastrointestinal system and the pancreas. His journey is driven by curiosity and the desire to improve his own quality of life, while helping others who face similar challenges. He shares critical lessons learned along the way: the importance of patience, giving your body time to heal, understanding nutrition and diet, and adopting a long-term mindset for recovery instead of rushing back to normal life too quickly. Jon emphasizes that every patient's journey is unique, encouraging ongoing screenings and self-advocacy. With honesty and humor, he shares practical insights from his own experience, offering guidance for anyone navigating life after a Whipple procedure or dual cancer diagnoses. Subscribe to the Project Purple Podcast to hear more stories from the pancreatic cancer community. And, if you'd like to learn more about or donate to Project Purple's mission of a world without pancreatic cancer, please visit https://www.projectpurple.org/.

In today's episode, we had the pleasure of speaking with Shubham Pant, MD, MBBS, about the first-line treatment of patients with metastatic pancreatic cancer. Dr Pant is a professor in the Department of Gastrointestinal (GI) Medical Oncology of the Division of Cancer Medicine, director of Clinical Research, and a professor in the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center in Houston. In our exclusive interview, Dr Pant discussed factors that drive frontline chemotherapy selection for metastatic pancreatic cancer, the role of NALIRIFOX (irinotecan liposome [Onivyde], oxaliplatin, 5-fluorouracil, and leucovorin) in this treatment setting, and how the first-line treatment paradigm may evolve and expand going forward.

Top Stories for November 29th Publish Date: November 29th PRE-ROLL: SUGAR HILL ICE SKATING From the BG AD Group Studio Welcome to the Gwinnett Daily Post Podcast. Today is Saturday, November 29th and Happy Birthday to Vin Scully I’m Peyton Spurlock and here are your top stories presented by Gwinnett KIA Mall of Georgia. Piedmont Oncology Opens Early Detection Pancreatic Cancer Clinic, First of Its Kind in Georgia You can now use a digital driver’s license to buy beer, cigarettes in Georgia Musical events, attractions to get into the magical spirit of the holiday season All of this and more is coming up on the Gwinnett Daily Post podcast, and if you are looking for community news, we encourage you to listen daily and subscribe! Break 1: Kia Mall of Georgia STORY 1: Piedmont Oncology Opens Early Detection Pancreatic Cancer Clinic, First of Its Kind in Georgia Piedmont Oncology just opened Georgia’s first Early Detection Pancreatic Cancer Clinic, and honestly, it’s a big deal. Pancreatic cancer is brutal—13% five-year survival rate, no screening test, vague symptoms that sneak up on you. But this clinic? It’s here to change that. Dr. Andrew Page, the clinic’s medical director, says early detection is everything. “Education about risk factors is critical,” he explained. The clinic will focus on genetic counseling, research collaborations with NIH and Mayo Clinic, and, hopefully, developing a much-needed screening test. None of this would’ve happened without donors like Purple Pansies. Their support is saving lives. STORY 2: You can now use a digital driver’s license to buy beer, cigarettes in Georgia Big news for Georgians: you can now use a digital driver’s license to buy alcohol, tobacco, and other age-restricted items. Yep, your phone just got even more useful. The Georgia Department of Driver Services (DDS) announced the update Monday, calling it a “major step forward” in modernizing IDs. But here’s the catch: it’s up to individual businesses to accept them. No guarantees. Oh, and don’t try using a screenshot—doesn’t count. Retailers need a special mDL reader to scan the license, and staff still have to verify your age. Progress? Sure. Perfect? Not quite yet. STORY 3: Musical events, attractions to get into the magical spirit of the holiday season It’s that time again—holiday magic is everywhere, and Atlanta’s got no shortage of ways to celebrate. From concerts to tree lightings, here’s what’s happening: Holiday Shows at the FOX Theatre: Lauren Daigle’s Behold Christmas Tour (Dec. 4): Grammy-winning magic. Christmas Together (Dec. 6): Amy Grant, Cece Winans, and Michael W. Smith. A Drummer Boy Christmas (Dec. 8): for King + Country’s festive storytelling. Elf the Musical (Dec. 16–20): Buddy’s heartwarming journey. Nutcracker! Magical Christmas Ballet (Dec. 23–24): Ballet meets acrobatics. Festive Attractions: Stone Mountain’s Flight to the North Pole (Nov. 8–Jan. 4): Help Santa save Christmas. Garden of Lights (Nov. 15–Jan. 11): Stroll through dazzling displays. Georgia Aquarium Holidays (Nov. 14–Jan. 2): Twinkling lights, Santa, and sea life. Don’t miss these great events! We have opportunities for sponsors to get great engagement on these shows. Call 770.874.3200 for more info. We’ll be right back Break 2: Ingles Markets - DTL HOLIDAY STORY 4: Student loan change could drain nurse pipeline, Ga. dean warns Nursing is no longer considered a “professional degree” by the U.S. Department of Education, and nurses are, understandably, furious. The change, tied to the “One Big Beautiful Bill”, means nursing students can’t access the $200,000 loan cap reserved for professional programs. Instead, they’re stuck with a $100,000 limit—less than what many need to cover tuition. Linda McCauley, dean of Emory’s Nursing School, didn’t hold back: “In a time when we desperately need more nurses, why make it harder? It feels like they didn’t think this through.” The fallout? Fewer nurses, more debt, and a lot of frustration. STORY 5: Flight delays: Here are your rights when flying over the holidays in 2025 Stuck at the airport? Here’s a tip: if your flight’s delayed more than three hours (domestic) or six hours (international), you’ve got rights. Travel expert Katy Nastro says airlines must offer a refund or rebook you—your choice. But here’s the catch: no double-dipping. You can’t get both. And meal vouchers? Only if the delay’s the airline’s fault, like staffing or mechanical issues. Hotels? Depends on the airline. The Department of Transportation even published a guide for what airlines owe you. Pro tip: screenshots of your license don’t count for ID. Break 3: BUFORD HOLIDAY FESTIVAL STORY 6: Forsyth school board approves use of same alarm system in place at Apalachee High School Forsyth County schools are stepping up safety with a $2.4 million Centegix alarm system, approved by the Board of Education this week. You’ve probably heard of these “panic alarms”—they’re the same system credited with the quick response during the tragic Apalachee High School shooting last year. Teachers and staff wear a button they can press in emergencies, instantly alerting law enforcement without fumbling for a phone. The system also includes color-coded strobe lights for visual alerts, ensuring ADA compliance. The first year’s cost? $420,000, with the rest spread over five years. Safety, it seems, is getting an upgrade. STORY 7: Recall alert: Honda recalls 256K vehicles for loss of power software error Honda’s recalling over 256,000 vehicles—specifically 2023–2025 Accord Hybrids—because of a software glitch that could cause the car to lose power mid-drive. Not ideal, right? The issue? The integrated control module’s CPU might reset itself while you’re cruising along. Dealers will fix it for free, though, so there’s that. Honda says owners will get a heads-up by mail starting Jan. 5, but if you’re the impatient type (or just worried), you can call them at 888-234-2138. Oh, and if you’re curious, the recall number is TN2. Stay safe out there! We’ll have closing comments after this Break 4: THE SUGAR HILL HOLIDAY Signoff – Thanks again for hanging out with us on today’s Gwinnett Daily Post Podcast. If you enjoy these shows, we encourage you to check out our other offerings, like the Cherokee Tribune Ledger podcast, the Marietta Daily Journal, or the Community Podcast for Rockdale Newton and Morgan Counties. Read more about all our stories and get other great content at www.gwinnettdailypost.com Did you know over 50% of Americans listen to podcasts weekly? Giving you important news about our community and telling great stories are what we do. Make sure you join us for our next episode and be sure to share this podcast on social media with your friends and family. Add us to your Alexa Flash Briefing or your Google Home Briefing and be sure to like, follow, and subscribe wherever you get your podcasts. Produced by the BG Podcast Network Show Sponsors: www.ingles-markets.com www.kiamallofga.com 2025 Buford Holiday Festival & Parade All-In-One Flyer Holiday Celebration 2025 – City of Sugar Hill Ice Rink – Downtown Sugar Hill NewsPodcast, CurrentEvents, TopHeadlines, BreakingNews, PodcastDiscussion, PodcastNews, InDepthAnalysis, NewsAnalysis, PodcastTrending, WorldNews, LocalNews, GlobalNews, PodcastInsights, NewsBrief, PodcastUpdate, NewsRoundup, WeeklyNews, DailyNews, PodcastInterviews, HotTopics, PodcastOpinions, InvestigativeJournalism, BehindTheHeadlines, PodcastMedia, NewsStories, PodcastReports, JournalismMatters, PodcastPerspectives, NewsCommentary, PodcastListeners, NewsPodcastCommunity, NewsSource, PodcastCuration, WorldAffairs, PodcastUpdates, AudioNews, PodcastJournalism, EmergingStories, NewsFlash, PodcastConversations See omnystudio.com/listener for privacy information.

What Thanksgiving traditions do you have? Do you eat a big meal surrounded by family, a smaller meal with less people, or Thanksgiving is not really your thing? In this week's episode of The Crushing Debt Podcast, we wish everyone a Happy Thanksgiving.  As has become our tradition, because we release the show every Thursday, Shawn & George talk about: Black Friday and Sales / Shopping Financial Advice around the dinner table What business owners can be thankful for this year Gratitude mindset Using Thanksgiving to air out financial dirty laundry Using Thanksgiving as a time to reflect and set goals for next year. Whether you celebrate, whehter you work tonight, whether you keep it low key or skip the holiday altogether, at The Crushing Debt Podcast, we do want to know what you're thankful for and we hope you have a great holiday season. Let us know if you enjoy this episode and, if so, please share it with your friends! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt   To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach   To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com. And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026  

You can make a tax deductible donation here: https://me-onefoundation.networkforgood.com/projects/37321-keeping-life-s-scoreboard-at-cancer-zero-me-one. If every subscriber donated ONE DOLLAR you could fund this wonderful organization for an entire year! Finding Hope & Healing: The Me-One Foundation & Camp Wieser with Erica Pope & John Burke Join us for an inspiring conversation with Erica Pope, Executive Director of the Me-One Foundation, and John Burke, Camp Director of Camp Wieser. They'll share the mission of this incredible nonprofit, which provides a cost-free retreat for adult cancer patients and their families, offering a weekend filled with joy, support, and unforgettable memories. We'll explore the history of Camp Wieser and how it came to be, the Me-One Foundation's mission to ease the burden of cancer through laughter, courage, and hope, John Burke's personal cancer journey and how he became the heart of Camp Wieser as Camp Director, and how you can support and get involved to help keep Camp Wieser completely free for families facing cancer. You can watch what Camp Wieser is all about here: https://youtu.be/SFDX2UbZ6Fk?feature=shared Learn more about the Me-One Foundation and their program, Camp Wieser here: https://me-onefoundation.org/ You can donate today to help keep Camp Wieser completely free for all campers here: https://me-onefoundation.networkforgood.com/projects/37321-keeping-life-s-scoreboard-at-cancer-zero-me-one. Erica Pope, Executive Director of the Me-One Foundation, leads the all-volunteer organization dedicated to giving adult cancer patients and their families a weekend of rest, connection, and joy at Camp Wieser—all at no cost to the campers. She works to expand the foundation's reach, deepen community engagement, and inspire donors and ambassadors. Erica is an active nonprofit leader, serving on the board of the Association of Fundraising Professionals California Capital Chapter and participating in the Rocklin Leadership cohort. John Burke, Camp Wieser's longtime Camp Director, has guided the retreat for over 14 years. A cancer survivor and former three-time camper, he brings personal insight and empathy to every aspect of the experience. John's background in event planning and marketing—including seven years with Disney—supports his leadership on the Me-One board, where he represents the patient perspective. His dedication helped move the camp to its current home in the Santa Cruz Mountains, ensuring comfort, privacy, and a healing environment for families. Diagnosed with stage IV pancreatic cancer in 2006, John attended the very first camp—an experience that brought his family hope and connection during an overwhelming time. Now preparing for his 17th camp, he remains committed to creating a space where others can find the same relief, renewal, and strength he found years ago. Please share this episode to help spread the mission of Me-One and Camp Wieser. Follow them on social media: https://www.instagram.com/meone_foundation/ https://www.facebook.com/meonefoundation

Stefanie Condon-Oldrieve of Craig's Cause joined 980 CFPL's Mike Stubbs to talk about pancreatic cancer diagnoses in Canada.

Host: Mindy McCulley, MS Family and Consumer Sciences Extension Specialist for Instructional Support, University of Kentucky  Guest: Dr. Joseph Kim, MD Professor and Chief of Surgical Oncology, University of Kentucky Markey Cancer Center Cancer Conversations Episode 69 Cancer Conversations on Talking FACS welcomes Dr. Joseph Kim, Professor and Chief of Surgical Oncology at the University of Kentucky, to discuss pancreatic cancer — a rising and deadly disease. They cover why pancreatic cancer is often detected late, common symptoms such as jaundice, the role of family history, and the single most important modifiable risk factor: smoking. The episode highlights an exciting individualized vaccine approach using tumor sequencing to create patient-specific vaccines sent from Europe after surgical removal of resectable tumors — intended to prevent or delay recurrence rather than prevent the initial disease. Eligibility, limitations (must be surgically removable), and the broader potential for vaccine technology in other cancers are explained. Listeners will learn practical takeaways: seek medical attention for persistent or new symptoms, discuss family history and risk with providers, and learn about ongoing clinical trials and resources at UK Markey Cancer Center for patients in Kentucky and surrounding areas. Connect with the UK Markey Center Online Markey Cancer Center On Facebook @UKMarkey On X @UKMarkey

November 24, 2025 ~ 'JR Morning celebrates Gratitude Week by talking with Dusty Mysen, a 46-year-old Oxford Resident and Pancreatic cancer survivor, and Henry Ford Health Surgical Oncologist Dr. David Kwon about his journey towards surviving cancer. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Exocrine pancreatic insufficiency (EPI) affects many patients with pancreatic cancer, yet it is often overlooked in this patient populations, which leads to malnutrition. In this episode, we are joined by Dr. Shelby Yaceczko, DCN, RDN, CNSC. Yacescko is a supporting author on a recently published White Paper on the topic, and she explains what EPI is, how to screen for and treat the condition, and the essential role of dietitians in an interdisciplinary care team managing these patients.  In this episode, we discuss: How overlapping GI symptoms, lack of standardized screening tools, and limited guidelines contribute to missed diagnoses and delayed treatment What inspired the development of the White Paper How to bring EPI management into everyday practice The ready-to-use checklists, screening forms, and EHR templates within the White Paper designed to standardize treatment Hosted by Kristin Houts Click here for the shownotes. The content, products and/or services referred to in this podcast are intended for Health Care Professionals only and are not, and are not intended to be, medical advice, which should be tailored to your individual circumstances. The content is for your information only, and we advise that you exercise your own judgement before deciding to use the information provided. Professional medical advice should be obtained before taking action. The reference to particular products and/or services in this episode does not constitute any form of endorsement. Please see here for terms and conditions.

Do you know what taxes are dischargeable in bankruptcy and which are not? Do you owe Trust Fund Tax?  What if you cannot pay it? On this week's episode of the Crushing Debt Podcast, Shawn & George talk to Tax Attorney Alena Miles. Alena has an L.L.M. in taxation, and is a CPA.  She is the founder of Attorney Legal and focuses her practice on federal tax law and international tax matters. She provides services in business tax planning, tax transactions, tax consulting, and tax controversy for a wide range of clients, including businesses, partnerships, corporations, LLCs, private equity funds, single-purpose entities, and individuals. With over 15 years of experience in public accounting, Alena has a strong background in tax compliance, tax planning, and tax dispute resolution. Before becoming an attorney, she worked as a Certified Public Accountant (CPA), assisting clients in industries such as asset management, real estate, McDonald's franchisees, professional services, investment, and construction. Alena has worked at leading Big Four accounting firms like PricewaterhouseCoopers (PwC) and KPMG, where she provided tax services to billion-dollar clients in asset management. As a Tax Manager at KPMG, she managed complex private equity funds and multi-tiered partnership structures, ensuring compliance with complex tax laws and regulations and meeting time-sensitive deadlines. Shawn & George talk to Alena about: Trust Fund Taxes Not Filing Your Tax Return Filing Late Returns Forced Filings by the IRS Negotiations with the IRS The Difference between a Tax Attorney and CPA FIRPTA (Foreign Investment in Real Property Tax Act) Let us know if you enjoy this episode and, if so, please share it with your friends! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt   To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach   To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com. And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026 

In episode 97 of the Summits Podcast, co-hosts Vince Todd, Jr. and Daniel Abdallah are joined by Courtney Roberts, President/CEO of Riley Children's Foundation. Tune in as Courtney shares about caregiving through her father's pancreatic cancer journey and the future of pediatric care at Riley Children's Health. “We want to ensure at Riley Children's Foundation that we are able, through philanthropic support, to ensure that every kid in the state of Indiana and beyond has access to the world-class care at Riley.”

November 20th is World Pancreatic Cancer Awareness Day, and specialists along with Pancreatic Cancer Ireland are calling for rapid access to diagnostic clinics, as it is projected to become the second leading cause of cancer-related death by 2030…Joining Seán Defoe to discuss this is Professor Tom Gallagher, Consultant Surgeon at the National Surgical Centre for Pancreatic Cancer at St. Vincent's University Hospital.

Gibraltar has a new world champion - 16-year-old Lewis Llamas, crowned at the IDO Show Dance World Championships.It's Pancreatic Cancer Awareness Day, and we'll hear an extraordinary survival story from Louis Baldachino, who defied a stage-four diagnosis ten years ago.The 3rd Europa Scout Group readies for the 10th anniversary of their GBC Open Day Treasure Hunt. Jonhenry Mauro, the man behind the riddles, joined us. And get ready to dance — BollyFit brings Bollywood-inspired fitness to Bayside Dance Studio on Monday for the GBC Open Day. Parissa Khiani and Priyana Budhrani will tell us more. Hosted on Acast. See acast.com/privacy for more information.

Today is World Pancreatic Cancer Day, and Kaz opens up to Tubes about her experience losing a family member to the disease, and the urgent need for action.See omnystudio.com/listener for privacy information.

From Federal Warden to Leadership Consultant: Darlene Drew on Building Your Practice, Pricing Mistakes, and Running a Business Through Grief (The Price and Value Journey, Episode 153) Do you want to know how to build a professional services business when you have deep expertise but no client base? Darlene Drew shares exactly how she did […]

Pancreatic cancer is the deadliest common cancer, with more than half of people dying within three months of diagnosis and 80% of people diagnosed at a late stage.In this episode of the Clinical Update podcast, part of MIMS Learning's ‘Patient, Presentation, Pathway for Cancer' campaign, Rhiannon speaks to Rachel Richardson, a pancreatic cancer specialist nurse at Pancreatic Cancer UK.During their discussion, they consider the common but often vague symptoms patients may experience, including abdominal/back pain, unexplained weight loss, and new-onset diabetes. Rachel says: ‘Research does highlight that over 90% of pancreatic cancer patients will actually visit their GP with relevant symptoms in the 2 years before they're diagnosed. So really this represents such a crucial window of opportunity for earlier detection.'The discussion also covers key risk factors, the important link between pancreatic cancer and type 3c diabetes, and new diagnostic tools in development – such as breath and blood tests – that could help GPs detect pancreatic cancer earlier.Educational objectivesAfter listening to this podcast, healthcare professionals should be better able to:Recall the common, but often vague symptoms, of pancreatic cancerIdentify key risk factors, including age, family history, smoking, obesity and pancreatic cystsUnderstand the link between type 3c diabetes and pancreatic cancerRecognise the challenges in diagnosis, including late presentation and non-specific symptomsDescribe promising new diagnostic tools in development, such as breath and blood testsYou can access the website version of this podcast, along with a list of key learning points, on MIMS Learning - and make notes for your appraisal.MIMS Learning offers hundreds of hours of CPD for healthcare professionals, along with a handy CPD organiser.Please note: this podcast is presented by medical editors and discusses educational content written or presented by doctors, nurses and other healthcare professionals on the MIMS Learning website and at live events.MIMS LearningSubscribe to MIMS LearningPodcast: Professor Willie Hamilton on cancer risk assessment toolsPodcast: Dr Patrick Holmes on identifying type 3c diabetes in primary carePancreatic cancer - red flag symptomsOther resourcesPancreatic Cancer UK. Health professionals page.Pancreatic Cancer UK. Family history checker Hosted on Acast. See acast.com/privacy for more information.

What lessons can you learn about selling from your kids? What lessons can you learn about debt from your kids? While we didn't get to participate in this year's community garage sale, my son did collect, clean and sell golf balls at a golf tournament recently. Some of the lessons he learned: Timing - know your market and their needs Networking - with other kids selling other items (like lemonade) Preparation - collecting, cleaning, sorting, labelling and pricing Investors - (dad, Shawn) to help buy supplies, provide the table for selling, etc. Using Revenue to Grow the Business (listen for the story of the golf ball cleaner) Let us know if you enjoy this episode and, if so, please share it with your friends! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt   To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach   To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com. And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026 

Broadcast from KSQD, Santa Cruz on 11-06-2025:>/p> Dr. Dawn interviews Cindy Jackonette and Dr. Michael Alexander about a fundraiser for pancreatic cancer awareness on November 15th at Bargetto Winery from 2-5pm, supporting the Santa Cruz Cancer Benefit Group. Dr. Alexander explains pancreatic cancer has only 10-15% five-year survival rates and is difficult to screen for. Screening involves complex endoscopy procedures examining pancreatic ducts, CT scans and biomarker scans. The disease represents 3% of cancer cases but 8% of deaths. Immune checkpoint inhibitors show limited success except in Lynch syndrome patients with DNA repair defects. The Santa Cruz Cancer Benefit Group donates annually to local cancer organizations and is all volunteer-run with minimal overhead. An emailer asks when her 56-year-old half-African American son should get colon cancer screening given his father and uncle both had the disease. Dr. Dawn explains African Americans have increased risk and recommends immediate colonoscopy despite the ideal screening window being 10 years ago. She emphasizes identifying whether he produces polyps, which would require surveillance every 3-5 years. Unlike pancreatic cancer, colon cancer is highly curable when detected early, with death rates dropping 30-40% since colonoscopies became standard in the mid-1990s. She recommends preventive measures including daily 200mg ibuprofen (if no ulcer history) and a high-fiber diet rich in colorful vegetables containing antioxidants that reduce oxidative stress and DNA damage from free radicals. An emailer from Israel asks about supporting his 38-year-old son's rectal adenocarcinoma treatment. Dr. Dawn recommends nutritional strategies including juicing 10 different fruits and vegetables daily, 20mg melatonin for synergy with chemotherapy, vitamin D supplementation, and L-glutamine as primary food for bowel healing and lymphocyte function. She suggests DHA fish oil to enhance chemotherapy effectiveness, green tea for oncogene inhibition, astragalus herb to increase phagocytic activity and natural killer cells, and rotating water-extracted mushroom formulas with beta-glucans, particularly maitake and shitake. Glutamine also protects mucous membranes from radiation burns. Dr. Dawn discusses alarming cancer rate increases among young adults in Corn Belt states including Iowa, Nebraska, Illinois, Minnesota, Indiana, and Kansas. Since 2015, these states show 5% higher cancer rates for ages 15-49 compared to national averages, with particularly elevated kidney and skin cancer rates. Young women face 66% higher skin cancer risk than peers in other states. . Governor Kim Reynolds invested $1 million for research while Bayer's attempt to shield Roundup from lawsuits failed. Dr. Dawn notes Roundup now contains diquat after removing glyphosate. It has taken decades to accumulate evidence of glyphosates harms, She warns that absence of evidence of Diquats being harmful isn't evidence of safety and that Ames testing suggests high mutation potential. An emailer shares a JAMA article on lithium for Alzheimer's disease. Dr. Dawn explains that calcium dysregulation through NMDA receptors plays an upstream role in Alzheimer's pathology. Lithium, a bipolar disorder treatment, can reset deranged calcium gates, inhibiting mitochondrial damage and tau protein production. She emphasizes tau protein as the true culprit in Alzheimer's while amyloid beta is more symptomatic. Correcting calcium homeostasis allows neuronal autophagy systems to clear waste more efficiently rather than being overwhelmed. She reports dramatic peanut allergy declines following 2017 pediatric recommendations for introducing peanuts at 4-6 months based on the LEAP study showing 81% reduction. Between 2017-2020, peanut allergies dropped from 0.79% to 0.45% of all children under 3, with overall food allergies declining 36%. Studies also show pregnant mothers eating peanuts reduces offspring allergy risk by promoting immune tolerance. We conclude with breakthrough wireless retinal implants for macular degeneration, where cameras on glasses convert images to near-infrared signals to retinal implants which stimulate surviving retinal neurons. The prototype allowed patients to improve by two lines on eye charts and perceive facial expressions and read smaller print.

Danielle Buchanan, a proud Texan, devoted wife, and mother of three boys shares her deeply personal and inspiring journey on this episode of the Project Purple Podcast with host Dino Verrelli. A registered nurse and lifelong picture of health, Danielle reflects on how her life changed suddenly in February 2021, when unusual symptoms after a family Super Bowl celebration led to imaging that revealed a mass on her pancreas. Just 48 hours later, on her 48th birthday, she was diagnosed with Stage 2A pancreatic cancer. She describes her grueling treatment journey, including chemotherapy, radiation, and the complex Whipple procedure, and how she has fortunately had no evidence of disease since early 2022. Danielle also opens up about her survivor's guilt, and emphasizes the critical role of hope and community support, from family members who cared for her three boys to the “prayer warriors” who surrounded her. Danielle reveals that during a difficult period of depression post-treatment, she felt a clear calling from God to return to nursing, but with renewed purpose. Now working full-time as a radiation nurse in an oncology infusion center, she supports patients undergoing chemotherapy, and Danielle shares that she draws from her own journey to offer compassion, insight, and hope. She smiles as she shares how she is now living life to the fullest and encourages others facing pancreatic cancer that they can, too. Danielle urges everyone to advocate for themselves and to “hold on to hope like it's your job,” reminding us all that even a difficult diagnosis doesn't define the life you can live. Subscribe to the Project Purple Podcast for more stories from the pancreatic cancer community. To learn more or donate to Project Purple's mission of a world without pancreatic cancer, please visit www.projectpurple.org.

Who's in more debt, Landlord or Tenant? How can landlords reduce costs and increase the profitability of their rentals? How can a property manager increase your profits and save you money? In today's episode, I interview Mark Sorokurs of Central Pinellas Realty and Collman Properties. I've known Mark about seven years and he's been in real estate for about eight years now after "retiring" from IT in 2012. You can also hear Mark in Episode 245 - Saving Money by Using a Property Manager You can reach Mark at www.centralpinellasrealty.com or office@colemanproperties.com., or 727-738-RENT (7368). Let us know if you enjoy this episode and, if so, please share it with your friends, like and subscribe to the show! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt   To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach   To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com. And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026 

Pancreatic cancer is one of the deadliest cancers, and smoking pushes the disease to appear earlier in life and progress more aggressively Chemicals in cigarette smoke flip immune cells into roles that protect tumors instead of fighting them, leaving your body defenseless Smokers build up more regulatory T cells, which shut down natural anti-cancer immunity and make treatment outcomes worse Cigarette smoke activates scarring and chronic inflammation in your pancreas, creating a hardened environment where tumors thrive and resist therapy Quitting smoking is a direct way to protect your pancreas and lower your cancer risk

Happy Halloween! On October 31, do you give out candy? Do you turn your lights off and pretend not to be home? Do you go to Halloween parties? What "vampires" are out there sucking your wallet dry? On this week's episode, Shawn & George take a funny look at those "vampires" that you should avoid, like Subscription Vampires Convenience Fee Vampires Tipping Vampires Lifestyle Vampires Tax Debt Vampires Buy Now, Pay Later Vampires Friend / Family Vampires Overdraft Vampires Store Credit / BOGO Vampires Interest Vampires And more ... You can also listen to other Halloween-themed shows like Episode 438: Debt Graveyard Episode 211: Zombie Cars Episode 88: Zombie Debt Let us know if you enjoy this episode and, if so, please share it with your friends! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com. And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026

Dr Norman Swan of the ABC's Health Report and the podcast, What's That Rash, joined Philip Clark and listeners to Nightlife.

So, Cleveland and the Browns have come to terms and in the not to distant future we will be a city of domed football.We offer up a Rest In Power to Michael Eugene Archer known to most as D'Angelo who left us far too soon due to pancreatic cancer. Governor DeWine, via executive order, has put a stop to sales of intoxicating hemp products throwing businesses that sell the stuff for a loop. Box got to hang with his pop againfor another local coin show so we talk precious metals some more. Tee wonders if his voice has a tone that makes his words seem sharper than intended, we then head to Reddit to discuss this week's AITA before wrapping it up with abit of entertainment chat. Thanks for hanging out with us, see you next time. Team SKiM Tatum | TAYREL713 | Lunchbox | LISTEN | RSS | Apple Podcast | Spotify | TuneIn | Bluesky | Amazon Music | YouTube | Email | Amazon Wish List | Merch | Patreon  PHONE l 216-264-6311 #Cleveland #Ohio #LiveFromThe216 #RIPDAngelo #FuckCancer #TheHypnotic #TheRoots #IladelphHalflife #IntoxicatingHemp #Parents #Coins #PreciousMetals#Communcation #TheGreatBritishBakeOff #ClairObscurExpedition33 #GhosofYotei #TonyaKappes#AutumnsAwningsandArson #DAngeloandtheVanguard #BlackMessiah  Alternative Title – When We Get ByLinksBusinesses Sue DeWine Over Intoxicating Hemp Ban, Say Executive Order Will Harm SalesD'Angelo Dead of Pancreatic Cancer at 51RedditAITAH for not siding with my wife over our son's ex girlfriend's pregnancyHe lied. AITAH for not siding with my wife over our son's ex girlfriend's pregnancyAITAH for videotaping my wife eating all my fries to make a point

How are you handling the rising cost of health care for your parents? How can you talk to your mother & father about the rising costs of health care and senior living? Should your parents age at home or in an assisted living facility? This week, Shawn & George talk to Rachel Aguanno, owner of Home Care Assistance Tampa Bay.  Rachel's company assists seniors to live at home. Rachel was a HUGE help to Shawn when his wife was in hospice at home at the end of 2023. Specifically, we talk about: Care-giving as a side job; What a home care assistance company can or cannot do; Any tax breaks, insurance, government programs, or veteran benefits available to help pay for home health care; Hospice v. Home Health Care v Assisted Living; Expenses people don't think about; and other budget considerations. Rachel can be reached at RAguanno@HomeCareAssistance.com or her website www.HomeCareAssistanceTampaBay.com.  Let us know if you enjoy this episode and, if so, please share it with your friends! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach   To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com. And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026 

In this eye-opening episode of the Project Purple Podcast, host Dino Verrelli has a compelling conversation with Amy Johnston of Pennsylvania, a 34-year-old mother of three young kids, who says that listening to her instincts and advocating for herself made all the difference in her journey with pancreatic cancer. Amy talks about how just a couple of months ago, she was at her healthiest—working out five days a week, eating better, and feeling strong after having her third child. Then, in January, she says she was suddenly hit with severe GI pain during dinner, and immediately knew something was not right. She describes how she was continually told by her doctors that it was nothing serious, even after asking several times if the problem was related to her pancreas. Frustrated, Amy shares that she switched doctors and hospitals, which eventually led to the discovery of a 1.7 cm tumor. After a biopsy confirmed pancreatic cancer, she recounts the shock of learning the tumor had actually been visible months earlier, but was missed due to poor imaging and assumptions based on her youth. Choosing to have surgery at the University of Pennsylvania, Amy shares how she underwent a distal pancreatectomy and splenectomy in May. In early June, she began her 12 rounds of chemotherapy and shares candidly about the challenges of treatment and the importance of staying active and positive despite the fatigue and side effects. She also talks about the comfort she's found in community support, creative outlets like crocheting, and especially in her growing faith, sharing that she plans to be baptized in a few months. Her story is a powerful reminder of the importance of advocating for yourself and pushing for answers. Amy stresses, “If I hadn't switched doctors, I could have thought this was a stomach bug.” She encourages others to focus on the facts of their own situation, connect with others facing similar journeys, and maintain hope throughout. Tune in for an honest and inspiring episode about resilience, motherhood, and faith in the face of pancreatic cancer. Subscribe to the Project Purple Podcast for more powerful stories from the pancreatic cancer community. If you'd like to donate to or support Project Purple's mission of a world without pancreatic cancer, please visit https://www.projectpurple.org/ and follow us on social media with these links: https://www.facebook.com/Run4ProjectPurple https://www.instagram.com/projectpurple/ https://twitter.com/Run4Purple

Dr Akila Viswanathan talks with Dr Amol Narang about the latest edition of Seminars in Radiation Oncology focused on the multidisciplinary treatment of pancreatic cancer.

When does an entrepreneur make time? How can an entrepreneur work 27 hours a day? How hard (or easy) is work-life balance? On this week's episode, Shawn & George interview Tiffanie Kellog who today (if you're listening on the day of release) releases her FOURTH self-published book, The Entrepreneur's Guide to More Free Time.  Tiffanie is the Sock-it-to-'em Success Strategist!  Since 2005, Tiffanie has been revolutionizing entrepreneurs' paths, unlocking greater wealth, freedom, and joy! As the creator of “eTiffanies” — epiphanies inspired by Tiffanie — she is known for her signature socks (over 400 pairs!), a charming southern accent, and her unique ability to inspire and empower others. Whether delivering dynamic keynote presentations, training locally and globally (often virtually), writing her next book, or leading her More Abundant Entrepreneurs community, Tiffanie loves helping people create the life they desire. With a passion for blending fun and strategy, Tiffanie helps her clients focus on achieving their goals while loving the journey. Her secret to success? Loving what she does so much that no one can tell if she's working or playing! Are you ready to sock it to your challenges, make more money, save time, and have fun? This is Tiffanie's seventh appearance on the podcast: Episode 381 (Talking about the no spend challenge) Episode 332 (Making time to crush your debt) Episode 242 (More money through masterminds) Episode 146 (13 months a year) Episode 76 (Referrals for Life) Episode 48 (Knock your socks off Speaking) Now Tiffanie is working on time management, or priority management, and how you can avoid BSO (Bright Shiney Objects) in your day.  And rather than Work/Life balance, we focus on Harmony or being "Off Balance On Purpose." You can get your copy of Tiffanie's new book or her previous three books at www.TiffanieKellog.com. And, Tiffanie is giving all of our listeners a free gift by going to this link: https://moreabundantentrepreneurs.com/moretime  Let us know if you enjoy this episode and, if so, please share it with your friends! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt   To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach   To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com. And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026   

It's a wet, wet, wet Tuesday night for Mark Thompson and it's snowing in the Sierra Mountains. He had a weird celebrity encounter earlier today at the pharmacy with none other than Ashton Kutcher. R&B singer D'Angelo has died of pancreatic cancer at the age of 51.

TWiM explains studies that show that the oral bacterial and fungal microbiome are risk factors for pancreatic cancer, and the gut microbiome and pyruvate metabolism of older adults are a link between sleep quality and frailty. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Oral microbiome and pancreatic cancer risk (JAMA Oncol) 2025 Cancer Facts & Figures (ACS) Periodontal Disease: The Good, The Bad, and The Unknown (Front Cell Infect Micro) Socransky's disease complexes (Microorg) Microbiome, pyruvate metabolism, sleep quality, and frailty (Cell Rep) Pittsburgh Sleep Quality Index (pdf) How to score the sleep quality index (pdf) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

JCO PO author Dr. Bryson Katona at the University of Pennsylvania Perelman School of Medicine shares insights into his article, “Areas of Uncertainty in Pancreatic Cancer Surveillance: A Survey Across the International Pancreatic Cancer Early Detection (PRECEDE) Consortium” Host Dr. Rafeh Naqash and Dr. Katona discuss how, given differing guidelines as well as lack of detail about how PC surveillance should be performed, approaches to PC surveillance across centers often differs. TRANSCRIPT Naqash: Hello and welcome to JCO Precision Oncology Conversations, where we bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I am your host, Dr. Rafeh Naqash, podcast editor for JCO Precision Oncology and Associate Professor at the OU Health Stephenson Cancer Center at the University of Oklahoma. Today, I am thrilled to be joined by Dr. Bryson Katona, Director of the Gastrointestinal Cancer Genetics Program and Director of the Lynch Syndrome Program at the Penn Medicine's Abramson Cancer Center, and also lead author of the JCO PO article entitled "Areas of Uncertainty in Pancreatic Cancer Surveillance: A Survey Across the International Pancreatic Cancer Early Detection or PRECEDE Consortium." Bryson, thanks for joining us again. Dr. Bryson Katona: Well, thank you so much for having me. I appreciate the opportunity. Dr. Rafeh Naqash: It is exciting to see that this work will be presented concurrently with the upcoming CGA meeting. Dr. Bryson Katona: Yes, it has been a fantastic partnership between JCO PO and the CGA-IGC and their annual meeting. And for those who may not be familiar, the CGA-IGC is the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer. It is basically a professional organization dedicated to individuals who have hereditary GI cancer risk and focusing on providing education, promoting research, and really bringing together providers in this space from not just throughout the US but from across the globe as well. Dr. Rafeh Naqash: That is exciting to hear the kind of work you guys are doing. These are definitely interesting, exciting things. Now, going to what you have published, it is an area that is very evolving in the space of cancer screening, cancer surveillance, especially for a very aggressive cancer such as pancreatic cancer. Could you tell us currently, what are the general consensus? I know there are a lot of differences between different guidelines or societies, but what are the some of the commonalities if we were to start there first for pancreas cancer screening? If you are not a GI oncologist, you may not be aware that there is something with regards to pancreas cancer screening. Could you give us an overview and a background on that? Dr. Bryson Katona: Yeah, I think that pancreatic cancer screening really is one of the most controversial areas of all cancer screening. Part of that controversy is just because all the guidelines, the many different guidelines that are out there, do not always match up with one another, which I think leads to a lot of confusion, not just for providers but for patients who are trying to go through this, and then also the insurance companies in trying to get these screening tests covered. You know, when we think about who is eligible for pancreatic cancer screening, you know, it is important that these are not average-risk individuals. So really, we are only offering screening to high-risk individuals. And those can include people that have a strong family history of pancreatic cancer without a germline genetic susceptibility that has been identified. And those individuals we refer to as having familial pancreatic cancer. And the other big cohort is those individuals that carry hereditary pancreatic cancer predisposition. These are due to cancer risk mutations in many different genes, including many of the breast cancer risk genes like BRCA1 and BRCA2, as well as ATM and PALB2, but then other genes such as the Lynch syndrome genes, and then some of the higher risk genes such as those leading to Peutz-Jeghers syndrome as well as FAM, which is due to CDKN2A mutations. Dr. Rafeh Naqash: Thank you for that. Again, another practical question, and this may or may not be exactly related to your specific topic here, but perhaps to some extent there might be an overlap. If I get a patient from a colleague, and I see people in the early-phase clinical trial setting, so many different tumors for novel drugs, and I find an individual with, let us say, lung cancer who has a pathogenic BRCA2, which is somatic, should I be worried about pancreas cancer screening in that individual? Or have we not met that threshold yet in that circumstance? Dr. Bryson Katona: A lot of times these variants or these genes that are associated with pancreatic cancer risk get picked up on the somatic tumor profiles. Now, you know, whether or not those are truly germline variants typically requires the next step of referring the patient for germline genetic testing. So you know, I would not screen or make any kind of screening choices based on a somatic variant alone, but nowadays germline testing is so easy, so efficient, and relatively cheap that it is easy enough to confirm whether or not these somatic hits are in fact just somatic or may confer some germline risk in addition. Dr. Rafeh Naqash: So from what I understand from what you have said, there is debate about it, but it is something that should be done or is important enough that you need to figure out a path moving forward. Was that one of the reasons why you performed this project through this very interesting consortium called the PRECEDE Consortium? Dr. Bryson Katona: Yeah, that was one of our main reasons for doing this. And for those who do not know about the PRECEDE Consortium, this is a very large international, multi-institutional organization really focused on reducing death and improving survival from pancreatic cancer, primarily through increased and more effective use of screening and early detection strategies. This is an international consortium. There are over 50 sites now with nearly 10,000 patients who are enrolled in the consortium. So it really is at this point the largest prospective study of individuals who are at high risk for pancreatic cancer who are undergoing screening. And you know, I think amongst all of us in the consortium, just amongst discussions between colleagues and then, you know, often times when I see patients that are transferring their care to Penn who maybe had their screening done in another center before, what we were realizing is that, you know, although we all do a lot of screening, it seems that people are doing it slightly differently. And it does not seem that there is a real consensus approach across all centers about how pancreatic cancer screening should really be done. And it is one thing if you are thinking comparing, okay, well, maybe in the US we do it differently than, you know, in Europe or in other locations, but even among centers within the United States, we were still seeing very large differences in how pancreatic cancer screening in high-risk individuals were done. And so that led us to really pursue this survey of pancreatic cancer screening practices across the PRECEDE Consortium. So for this survey, we actually have 57 centers who the survey was sent out to. As you know, surveys are oftentimes very difficult to get good response rates back on, but we were fortunate to have 54 of the 57, or 95% of the centers, actually get back to us about their screening practices for this particular project. Dr. Rafeh Naqash: That is good to know. I hope you did not have to use any kind of gift cards for people to respond to the survey. But nevertheless, you got the information that you needed. Could you tell us what are some of the common denominators that you did identify and some of the differences that you identified? From your perspective, it sounds like there is no established consensus guidelines. There are different societies that have different perspectives on it. So I am sure some of what you found will probably have implications in maybe creating some guidelines. Is that a fair statement? Dr. Bryson Katona: Definitely a fair statement, and we found some very interesting results. I think one important result is really just the heterogeneity in the consortium. And so even before we got into pancreatic cancer screening practices, we also, we were asking consortium sites, “At your particular site, who is the individual that is leading these in-depth discussions about pancreatic cancer screening?” And while about 50% of the sites had a gastroenterologist leading it, about a quarter of the sites had a medical oncologist, a quarter had a surgeon leading these discussions as well. And we also found heterogeneity in who is the physician or the provider actually ordering these screening tests, again, with multiple different specialties across the different sites. But really one of the main areas that we wanted to hone in and focus on was how the different pancreatic cancer screening guidelines were actually utilized in each of the particular centers. The biggest controversial area in the field is for the gene mutation carriers, whether or not we should be requiring that a family history of pancreatic cancer be present in order for those individuals to qualify for pancreatic cancer screening. And the reason that is so controversial, let us take an example of BRCA1 and BRCA2 carriers. Currently, if you look through the guidelines, NCCN and the ASGE guidelines recommend that really all BRCA2 carriers undergo pancreatic cancer screening regardless of whether or not there is a family history, starting at age 50. However, other guidelines such as the AGA guidelines, or the AGA Clinical Practice Statement, as well as guidelines from the CAPS consortium, do recommend that a family history of pancreatic cancer be present in order to qualify for screening. But then we have different things for other genes. So for BRCA1 carriers, in fact, it is the ASGE guidelines that recommend all BRCA1 and 2 carriers undergo screening, whereas NCCN and the other guidelines that are out there do not recommend those individuals undergo screening. Again, this huge heterogeneity in guidelines is quite striking. And so when we assessed all the sites in the PRECEDE Consortium, we found some really interesting results with respect to these particular genes. For BRCA2 carriers specifically, we found that about half of the sites required a family history for recommending pancreatic cancer screening, but about half of the sites would offer it to all BRCA2 carriers regardless of if there was a family history of pancreatic cancer screening. Rates for BRCA1, PALB2, and ATM carriers were a little bit lower, where about a third of sites would offer screening really regardless of whether or not there is a family history of pancreatic cancer. And for Lynch syndrome, those rates were very, very low, with only about 13% of sites offering screening to Lynch patients in the absence of a family history. But I think, you know, we are all in the same consortium, but there is still just a lot of heterogeneity in how our own individual practices are run. Dr. Rafeh Naqash: Definitely different thoughts, different practices. But from what you saw, did it matter as far as outcomes are concerned whether it was a gastroenterologist doing the screening, or it was a medical oncologist, or a geneticist? Or is it a combination of all of these that actually makes the most difference? Dr. Bryson Katona: So I think we do need to get some more information about specialty-specific screening preferences. We just had one response per site in this particular survey, and so I think we are going to need a larger sample size in order to get that data. But I think that is certainly possible that, you know, certain subspecialties may prefer, you know, screening more aggressively or not including family history. That is definitely a question that we will be asking in future studies. Dr. Rafeh Naqash: Definitely more gift cards that will be needed as well. Moving on to another aspect of the implications for early detection, from a breast cancer, colon cancer standpoint, there is health economics research that shows it saves cost in the bigger picture. Has there been anything for pancreas cancer where early detection, early identification, early treatment actually ends up saving a lot more versus detecting metastatic pancreas cancer later? Dr. Bryson Katona: It is a great question. And of course, for any screening modality, you know, we would ultimately want it to be a cost-effective measure. In pancreas cancer screening, the jury is still a little bit out about whether or not pancreas cancer screening is truly cost-effective or not. There have been several different studies that have assessed this. And I think in general, the thought is that it is a cost-effective endeavor. But I think most of these cost-effectiveness estimates are actually related to what is the risk of pancreatic cancer in the population you are studying. And so when you have very, very high-risk individuals that have over a 10% lifetime risk of pancreatic cancer, it is almost a certainty that pancreatic cancer screening is going to be cost-effective. However, you know, if you have, say for example, BRCA1 carriers where lifetime risk of pancreatic cancer may be less than 5%, likely around like 3%, those individuals, I think it is going to be a tougher sell to say that it is cost-effective. But as we get more data on pancreatic cancer screening, that will be a very important question to ask. And you know, when you mentioned how does it save money, our goal at least in pancreatic cancer screening is to really downstage pancreatic cancer at the time of diagnosis and allow someone to undergo, you know, ideally a curative-intent surgery. There is data out there showing that we can downstage the cancers, that survival after the time of diagnosis is substantially increased after detection in a pancreatic cancer screening program. But again, these are studies that are based on fairly small numbers of converters. And so I think we need more data in that space as well, which is one of the main questions that the PRECEDE Consortium is trying to answer with all of our prospective data. Dr. Rafeh Naqash: Excellent. Well, I hope we see more interesting, exciting work from the PRECEDE Consortium at meetings as well as as a publication in JCO PO. I would like to shift gears briefly for a minute or two, Bryson, to you as an individual, your career. How have you evolved over the last 5, 7 years? How did you end up doing cancer genetics? What were some of the lessons that you learned along the way and some of those that you would want to share with our listeners, especially trainees and early-career faculty? Dr. Bryson Katona: Just to give you and others listening a little bit of background, but I am a physician-scientist, gastroenterologist, but a physician-scientist. And so my clinical practice is exclusively focused on individuals with hereditary GI cancer risk. I run a basic science lab where we do a lot of studies in organoids and mouse models of these hereditary GI cancer risk syndromes. And then I also have a clinical research group where we do early-phase clinical trials and screening and early detection trials, again in these same individuals with hereditary GI cancer risk. I think probably the most important thing that kind of allowed me to get to this stage in my career where I am trying to, you know, essentially try to juggle all three of these balls at the same time is that I absolutely love what I do. And I am so incredibly interested in what I do. And I think for young individuals that are coming through the pipeline and going through training, you know, I mean, finding a specialty and a clinical niche where you truly just enjoy the work and you enjoy the patients and you enjoy your colleagues is by far the most important thing. I ended up getting into the hereditary GI cancer space because a lot of my work earlier on in my career during my PhD and then in my postdoc work in the lab really focused on colorectal cancer. And I thought that focusing on cancer genetics could allow me to really continue to think from the molecular side of things while simultaneously being a gastroenterologist and taking care of patients with hereditary cancer risk. Dr. Rafeh Naqash: Well, thank you so much for giving us a sneak peek of your journey and insights on what perhaps works best, especially when you love what you do. I think that is one of the most important reasons a work tries to keep you going and keep you interested, keep you passionate. So thank you again. Thank you for listening to JCO Precision Oncology Conversations. Do not forget to give us a rating or a review, and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

In this episode of the Tough Girl Podcast, I'm joined by the incredible Julie Weiss — also known as The Marathon Goddess. Julie's story is one of resilience, healing, and purpose. After losing her father to pancreatic cancer, she set out on an extraordinary mission: to run 52 marathons in 52 weeks, raising awareness and funds for pancreatic cancer research along the way. Her journey captured hearts around the world — from the Today Show and O Magazine to countless finish lines across the US. But behind the medals and media attention is a woman who found strength, joy, and hope through running. Now in her fifties, Julie has completed over 118 marathons, raised more than $1 million for research, and continues to inspire others with her message that it's never too late to chase your dreams, honour your loved ones, and find purpose in every step. In this conversation, Julie opens up about:  How running helped her heal from grief and depression  The challenges and triumphs of running 52 marathons in 52 weeks  What it takes to stay motivated and injury-free through massive goals  Her empowering “7 C's to Defy Your Limits” — Create, Certainty, Connect, Commit, Consistent, Cause, and Courage Julie's story is a beautiful reminder that transformation begins with one small step — and that every mile can make a difference.  New episodes of the Tough Girl Podcast drop every Tuesday at 7 AM (UK time)! Make sure to subscribe so you never miss the inspiring journeys and incredible stories of tough women pushing boundaries.  Do you want to support the Tough Girl Mission to increase the amount of female role models in the media in the world of adventure and physical challenges? Support via Patreon! Join me in making a difference by signing up here: www.patreon.com/toughgirlpodcast.  Your support makes a difference.  Thank you x Show notes Who is Julie Living in Santa Monica,  California, USA Being known as the Marathon Goddess - Running 52 marathon in 52 weeks Raising over $1 million for charity  Being excited to share the wisdom she has leaned from running marathons Her childhood and early years  Being tall with long legs Starting running at 37 years Not being at athlete at school Taking a different path Becoming a mother at 18  Not doing a lot of exercise in her younger years  Feeling at a very low point in her life Going for that first run on the beach  Wanting to feel good Keeping on running  Coming off anti-depressants  Fitting running into her life and making it work for her Joining a running group LA Road Runners Connecting with other people  Training for a triathlon first  Running her first marathon in March 2008 How running makes her feel  Her relationship with her dad Raising funds for Hirshberg Foundation for Pancreatic Cancer Research Taking 10 years to raise the funds  Project Purple Deciding to run 52 marathons in 52 weeks The Marathon Guy Being determined  Feeling overwhelmed at the start of the goal The start and the different steps involved Reaching out to charities, speaking to her boss The power of having purpose  The physicality of the challenge Protein, stretching, foam rolling, strength training, rest, compression tights, physio  The standout marathons from the challenge  The Leadville Marathon and the challenges of running at altitude   The Lake Tahoe Marathon The New York Marathon in 2012 - being cancelled   Marathon proposal! Being coached by her husband Qualifying for the Boston Marathon Losing her dad 19th attempt of getting into Boston Marathon Making the decision to run 52 marathons in 52 weeks Not giving up  The mental side of the challenge The importance of creating a goal that is important to you The 7Cs - Create, Certainty, Connect, Commit, Consistent, Cause, Courage  Enjoying what you've accomplished Writing her book  BOOK: The Miles and Trials of a Marathon Goddess: 52 Weeks, 52 Marathons Advice for deciding what to do? The importance of fun Chasing speed and wanting to quality for Boston again Running during peri-menopause and menopause Struggling with the lack of sleep and dealing with a lack of iron Compassion Reaching her 100th Marathon at the LA Marathon  Needing to keep on going  Being supported by her friends The importance of enjoying the journey and finding the joy How to connect with Julie  Words by ― CS Lewis “You are never too old to set a new goal or to dream a new dream.”   Social Media Website: www.julie-weiss.com  Instagram: @marathongoddess  Facebook: @Julie-WeissMarathonGoddess  

What is the real reason 90% of businesses fail? What are some bookkeeping or CFO mistakes most business owners make that can tank your business? On this week's episode of The Crushing Debt Podcast, George and Shawn talk to Emily Handren, owner and founder of Besty Bookkeepers (www.BestyBookkeepers.com).  For over two decades, Emily has helped individuals and businesses improve their financial situations through banking, investing, lending, and insurance guidance. She has owned both life/health and P&C agencies, and has plenty of real-world stories about helping people reduce costs and increase their net worth. Emily recently wrote a book "The Real Reason 90% of Businesses Fail: 101 Bookkeeping and CFO Mistakes You Can't Afford to Make"  that hit #1 in three categories: Small Business Bookkeeping, Entrepreneurship Management, and Business Planning & Forecasting. It focuses on practical money management strategies for businesses that could tie perfectly into debt reduction discussions. Here's the link if you'd like to check it out: https://a.co/d/2JDV3So In this episode, we talk about: Fractional CFO Bookkeepers v. Accountants Tech stacking Financial Forecasting Some of the 101 Mistakes, like: Exponential growth without a plan or foundation Improperty business structure knowing your expenses and your numbers using an outdated accounting system not paying yourself. You can reach Emily at her website www.BestyBookkeepers.com or Emily@BestyBookkeepers.com. Make sure you take the "Need a Better Bookkeeper" quiz on her website! Let us know if you enjoy this episode and, if so, please share it with your friends! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt   To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach   To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com. And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026 

Synthetic progestogens hike risk for brain tumors, natural progesterone safe; Healthy microbiome, good genes, clean lifestyle propel world's oldest woman to age 117; Can you take too much selenium? Cannabis extract scores vs. low back pain; Can vitamin K prevent breast calcifications? Are we making progress vs. pancreatic cancer? 

Vidcast:  https://www.instagram.com/p/DPa20mdDoub/University of Cincinnati oncologists have developed a drug that stops pancreatic cancer from suppressing the anti-tumor immunity that threatens to eradicate it.  Using a pre-clinical mouse pancreatic cancer model, the researchers pinpointed that the protein Hsp70 is produced by the cancer cells to defuse the anti-cancer immune response.Their next step was to find an antidote Hp70.  That they did by developing the rescue agent SapC-DOPG.  This drug adheres to pancreatic cancer cells, inhibits Hsp70, and destroys the tumor's shield against killer T lymphocytes.The next step is to bring this rescue compound and others like it into the clinic for an array of trials.  Hopefully, they will confirm the effectiveness of this concept and join the fight against this dread disease…..someday soon.#pancreatic #cancer #immunotherapy #hsp70 #sapCDOPGpancreatic, cancer, immunotherapy, hsp70, sapCDOP

What is the test for discharging a student loan in bankruptcy? Is it even possible? Student loans are non-dischargeable, right? WRONG !! On this week's episode, Shawn is back solo again (we'll hear George back again for next week's episode) interviewing attorney Jeff Hakanson.  Jeff has been an attorney for thirty (30) years! He granduating with his J.D. from South Texas College of Law and has practiced bankruptcy for his entire career.  On November 17, 2022, the U.S. Department of Justice issued a memorandum on student loan discharges.  What normally fell under the Brunner case and a Totality of Circumstances argument has now been streamlined by the US DOJ to assist in discharging student loan debts under certain circumstances, some of which include: The borrower is over 65; The borrower has a disability; The borrower has been unemployed 5 of the last 10 years; The borrower has attempted repayment in good faith. Typically these discharge cases are started with the filing of an Adversary Proceeding (with no fee if related to Student Loans) and then the debtor / borrower and attorney complete a "litigation package" with certain "attestations."  If the DOJ agrees, then the student loans can be discharged, or maybe modified in some capacity. The memorandum was designed to allow borrowers more clarity on discharging federally backed student loans (not private loans). Let us know if you enjoy this episode and, if so, please share it with your friends! Or, you can support the show by visiting our Patreon page: https://www.patreon.com/crushingDebt   To contact George Curbelo, you can email him at GCFinancialCoach21@gmail.com or follow his Tiktok channel - https://www.tiktok.com/@curbelofinancialcoach   To contact Shawn Yesner, you can email him at Shawn@Yesnerlaw.com or visit www.YesnerLaw.com.   And please consider a donation to Pancreatic Cancer research and education by joining Shawn's team (reactivated for 2026) at MY Legacy Striders: http://support.pancan.org/goto/MyLegacy2026   

Pancreatic cancer is among the deadliest forms of cancer, and Pennsylvania has one of the nation’s highest rates. For families like the Crosbys of Cumberland County, the disease has left a lasting mark — one they hope can spark more awareness, early detection, and support. The beginning of the school year is an exciting time, but many children will fall behind academically, developmentally and socially because of undetected vision issues. That is the concern of the Pennsylvania Optometric Association, POA, and the reason state lawmakers are sponsoring the Children’s Vision Bill. It calls for optometrists and ophthalmologists to perform vision exams at milestone years for students: kindergarten, fourth and eighth grades. The National Parent Teacher Association has reported that more than 10 million children in the U.S. suffer from undetected vision problems that can hamper learning success. Identifying those students who have vision-related deficiencies early on and getting them an effective diagnosis and treatment will make a significant impact on their overall quality of life and future. Support WITF: https://www.witf.org/support/give-now/See omnystudio.com/listener for privacy information.

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in the Pharma and Biotech world.## Immuneering's drug atebimetinib has shown promising results in doubling overall survival in pancreatic cancer patients after nine months. Truist analysts have deemed the results encouraging, although some unknowns remain in the data. Immuneering plans to initiate a registrational trial for atebimetinib later this year. ## In other news, Lilly has halted a mid-stage obesity study for strategic reasons, Harmony has failed a pivotal trial for fragile X syndrome, and the FDA has released guidance to streamline the development of cell and gene therapies. Overall, Immuneering's drug shows potential in improving survival rates for pancreatic cancer patients, with further trials planned for the future.

In this extremely motivational episode of the Project Purple Podcast, host Dino Verrelli speaks with Michael Kennedy of Vermont, a lawyer and avid runner whose 20 years on the roads and trails unexpectedly prepared him for the toughest marathon of his life: pancreatic cancer. Michael shares how his story began in 2023, a year packed with long runs, two marathons, and a 100‑mile relay. But when back pain crept in after the relay, he brushed it off as age or overtraining. But within weeks, his symptoms escalated: rapid weight loss, changes in digestion, and eventually, a scan soon confirmed what no runner expects to hear: a tumor was on his pancreas. He recounts how his diagnosis in October 2023 launched him into treatment with the same discipline he'd honed as an athlete. Michael reflects on the months of chemotherapy, the neuropathy that forced him to wear mittens just to grab milk from the fridge, and the exhausting stretch of radiation—all to make surgery possible. In June 2024, he underwent a Whipple procedure with an innovative addition he advocated to have: a cutting‑edge CIVASheet radiation implant that allowed him to avoid post‑surgery chemo. Michael also describes how, even through treatment, he kept running. Running became a lifeline: “It's not gonna take the things from me unless it beats 'em out of me,” he says. He explains how discovering Project Purple gave him something to look forward to: a goal of finishing a marathon in the same calendar year as his Whipple surgery. Just months after leaving the hospital, he crossed the finish line of a December marathon in Jacksonville wearing a Project Purple singlet, and has since completed other races with the organization. In this conversation, Mike opens up about scanxiety, hope, and the power of staying positive. He discusses how his runner's mindset and experience being a high school basketball coach have taught him that you can do hard things one step at a time, which helped him through chemo and into recovery. And he offers practical advice: know the symptoms, and when life hands you a challenge, focus on WIN: What's Important Now. Mike's story is one of three Ps: positivity, perseverance, and the unexpected ways our passions can prepare us for life's biggest battles. You can find Mike on Instagram at: http://instagram.com/mkennedyvt/ Subscribe to the Project Purple Podcast to hear more stories from the pancreatic cancer community. And, if you'd like to learn more about or donate to Project Purple's mission of a world without pancreatic cancer, please visit https://www.projectpurple.org/.

Pancreatic cancer is among the deadliest forms of cancer, and Pennsylvania has one of the nation’s highest rates. For families like the Crosbys of Cumberland County, the disease has left a lasting mark — one they hope can spark more awareness, early detection, and support.Support WITF: https://www.witf.org/support/give-now/See omnystudio.com/listener for privacy information.

Interview with Jiyoung Ahn, PhD, author of Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer. Hosted by Vivek Subbiah, MD. Related Content: Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer

In this episode of the Project Purple Podcast, host Dino Verrelli speaks with Carmen Stewart, a pancreatic cancer survivor from across the globe, calling in all the way from Johannesburg, South Africa. Her story is one of perseverance, clarity, and transformation in the face of staggering odds. Carmen opens up about her whirlwind diagnosis in 2020 at the height of the pandemic, which followed months of persistent pain, varying symptoms, and repeated misdiagnoses, from gastroenteritis and hepatitis. She talks about how she pushed for surgery before lockdown hit in her country, against her doctor's initial plan, and how she underwent a Whipple procedure alone, with no support system allowed into the hospital due to pandemic restrictions. She goes into detail about her surgery, saying her surgeon called it a “miracle,” as her tumor had been capped and fully contained, preventing the cancer from spreading. Carmen explains her recovery wasn't easy—it was complicated by sepsis, delays in chemotherapy, a contraction of COVID-19, and the emotional toll of isolation. Still, she forged ahead, adding that it was the help of natural therapies, the love of and from her daughters, and an unwavering will to survive that kept her going. Carmen speaks candidly about survivor's guilt and the reality of life after treatment, which changed drastically for her in many ways. Her perspective is grounded in realism: “If it comes back, I'll deal with it. But if I'm clear, that's great.” She discusses how her experience reshaped her life—from managing her health and finishing her degree, to letting go of fear and finding joy in the present. Her message is clear: trust your instincts, choose the right medical team, and don't ignore what your body is telling you. Tune in to hear Carmen's candid conversation about navigating illness during a global crisis, rebuilding after the trauma that comes with this disease, and finding meaning in survival. Subscribe to the Project Purple Podcast to hear more stories from the pancreatic cancer community. To learn more or donate to Project Purple's mission of a world without pancreatic cancer, please visit https://www.projectpurple.org/.

Honoring Lori: fighting pancreatic cancer with purpose Jennifer Peterson and Nicole Hawes are on the board of the Lori Peterson Cancer Foundation, which was created to honor the life and legacy of Lori Lynn Peterson, who courageously battled pancreatic cancer. Carrying forward her spirit, the organization is dedicated to advancing research, supporting treatment, and raising awareness for one of the toughest cancers to fight. The foundation has funded projects that bring hope, progress, and real impact for patients and families. They are turning loss into legacy and making a difference in the fight against pancreatic cancer.  

Potato intake and diabetes risk.How much daily leucine is required to regain muscle?

I have high LDL cholesterol and a '0' calcium score.  Why does my doctor insist I take a statin?How much vitamin D should I take?  Which product do you recommend?Some doctors assert omega-3s are proinflammatory.  What say you?Study: Magnesium intake may be beneficial in preventing pancreatic cancerDo you have any products to regrow hair?I have a calcium score, but prefer to avoid Lipitor.

In today's episode, we passed the mic to Tara E. Seery, MD, who moderated an OncLive Insights discussion on the future of the pancreatic cancer treatment paradigm. Rounding out the discussion with additional expert perspectives were Paul E. Oberstein, MD, and Priyadarshini Pathak, MBBS. Seery is a medical oncologist at the Hoag Family Cancer Institute in Newport Beach, California. Oberstein is an associate professor in the Department of Medicine at the New York University (NYU) Grossman School of Medicine; as well as the director of the Gastrointestinal Medical Oncology Program, the assistant director of the Pancreatic Cancer Center, and the service chief of the Gastrointestinal Medical Oncology Program at NYU Langone's Perlmutter Cancer Center. Pathak is an assistant in medicine at Massachusetts General Hospital and an instructor in medicine at Harvard Medical School in Boston.  In this exclusive conversation, Drs Seery, Oberstein, and Pathak highlighted key data from the phase 3 NAPOLI 3 trial (NCT04083235) of NALIRIFOX (liposomal irinotecan, 5-fluorouracil [5-FU], leucovorin, and oxaliplatin) vs nab-paclitaxel (Abraxane) and gemcitabine in treatment-naive patients with metastatic pancreatic ductal adenocarcinoma; the toxicity profiles of NALIRIFOX and FOLFIRINOX (leucovorin, 5-FU, irinotecan, and oxaliplatin); real-world data with these regimens, and more. 

This month, the Department of Health and Human Services terminated almost $500 million in mRNA vaccine development grants and contracts. While HHS has said that these cuts won't affect mRNA cancer research, some researchers have expressed concern about the impact on their ongoing work. In light of these developments, we're revisiting a conversation from February.A team at Memorial Sloan Kettering is developing an mRNA vaccine for pancreatic cancer, which is notoriously difficult to treat. A few years ago, the team embarked on a small trial to test the vaccine's safety. Sixteen patients with pancreatic cancer received it, and half of them had a strong immune response. A follow-up study found that in six of those patients, the cancer hadn't relapsed after three years.Host Flora Lichtman spoke to study author Vinod Balachandran about the work, which has not yet been affected by the cuts, according to Memorial Sloan Kettering.Guest: Dr. Vinod Balachandran is an associate attending surgeon and Director of The Olayan Center for Cancer Vaccines at Memorial Sloan Kettering in New York, New York.Transcripts for each segment will be available after the show airs on sciencefriday.com.  Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.