This Week in Neuroscience

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This Week in Neuroscience is a podcast about the nervous system.

Vincent Racaniello


    • Apr 2, 2025 LATEST EPISODE
    • monthly NEW EPISODES
    • 1h 7m AVG DURATION
    • 60 EPISODES


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    Latest episodes from This Week in Neuroscience

    TWiN 59: AI co-scientist

    Play Episode Listen Later Apr 2, 2025 74:45


    Tim explains AI co-scientist, a tool released by Google, which it hopes to help scientists generate hypotheses and research proposals, and to accelerate the speed of scientific and biomedical discoveries. Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server AI cracks superbug problem (BBC) Accelerating scientific breakthroughs (Google Research) Towards an AI co-scientist (arXiv) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 58: Tongue-dragging rescue behavior

    Play Episode Listen Later Mar 10, 2025 74:21


    TWiN explains a study showing that when a mouse is confronted with an unconscious conspecific, it engages in behavior including tongue-dragging to resuscitate the animal via a tongue-brain connection. Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Tongue-dragging in mice (Sci Adv) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 57: Repetitive injury, herpes, and Alzheimer's

    Play Episode Listen Later Feb 4, 2025 40:09


    TWiN discusses a study showing that repetitive injury reactivates HSV-1 in a human brain tissue model and induces phenotypes associated with Alzheimer's disease. Hosts: Vincent Racaniello and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Repetitive injury, herpes, and Alzheimers (Sci Signal) The tau of herpesvirus (TWiV 1187) Fishing for viruses in senile (TWiV 519) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 56: Astrocytes help neurons remember

    Play Episode Listen Later Nov 26, 2024 60:44


    TWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learning experiences, and regulate the flow of information during circuit plasticity and memory recall. Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Write your Senator, oppose RFK Jr nomination Astrocytes and memory (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 55: A brain circuit for day/night balance

    Play Episode Listen Later Oct 28, 2024 69:29


    TWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to photoperiod change. Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Brain circuit for photoperiod adaptation (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 54: How pregnancy transforms the brain

    Play Episode Listen Later Oct 1, 2024 65:25


    TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting. Hosts: Vincent Racaniello, Jason Shepherd, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Pregnancy transforms the brain (Nature) Hormone-mediated neural remodeling during pregnancy (Science) Effects of pregnancy on brain activity (Nature Comm) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 53: Slowing time by cooling the brain

    Play Episode Listen Later Jul 29, 2024 70:03


    Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Joseph J. Paton and Felipe Rodrigues Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Using temperature to analyze the neural basis of a time-based decision (Nat Neurosci) Hot times for the dorsal striatum (Nat Neurosci) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 52: Probiotic improves social behavior in children with ASD

    Play Episode Listen Later Jun 24, 2024 65:50


    Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD. Hosts: Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Mauro Costa-Mattioli Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Probiotics for autism spectrum disorder (Cell Host Microbe) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 51: Sensory processing dysfunction in autism spectrum disorders

    Play Episode Listen Later May 28, 2024 71:20


    TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models.  Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Mouse models of autism spectrum disorder (Nature Neuroscience) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 50: Neurological sequelae after COVID-19

    Play Episode Listen Later Apr 29, 2024 64:25


    TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19.  Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server SARS-CoV-2 perturbs synaptic homeostasis (Nature Micro) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all?

    Play Episode Listen Later Mar 25, 2024 91:25


    TWiN welcomes mice to the elite club of ‘self-aware' animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition.  Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Mice are self-aware (Neuron) Mirror self-recognition in mice (Neuron) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 48: Traumatic brain injury and retroviruses

    Play Episode Listen Later Feb 19, 2024 51:13


    TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury.  Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Activation of endogenous retroviruses in TBI oligodendroglia (Cell Rep) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 47: Walking after spinal cord injury

    Play Episode Listen Later Jan 29, 2024 55:25


    TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface.  Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Walking naturally after spinal cord injury (Nature) The paralyzed rat that walked (YouTube) Mike the headless chicken (Wikipedia) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 46: Neuronal activity promotes glioma progression

    Play Episode Listen Later Jan 1, 2024 51:04


    TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain.  Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Glioma synapses recruit mechanisms of adaptive plasticity (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 45: Acupuncture modulates the immune system

    Play Episode Listen Later Dec 13, 2023 52:24


    TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla.  Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Electroacupuncture modulates the immune system (Nat Med) Electroacupuncture drives the vagal–adrenal axis (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 44: ADHD and persistent pain

    Play Episode Listen Later Nov 2, 2023 60:41


    TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Pain hypersensitivity in ADHD model (PNAS) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 43: Pavlovian opioid tolerance

    Play Episode Listen Later Oct 4, 2023 62:41


    TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Associative opioid analgesic tolerance (Sci Adv) Pavlovian-conditioned opioid tolerance (Sci Adv) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 42: Therapeutic effects of psychedelic drugs

    Play Episode Listen Later Jul 18, 2023 56:34


    TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Click arrow to play Download TWiN 042 (34 MB .mp3, 57 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Psychedelic drugs open critical period (Nature) Psychedelics reopen critical periods (News-Med) LSD microdosing doesn't work (U Chicago Med) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 41: Alzheimer's and melanin-concentrating hormone

    Play Episode Listen Later Jun 20, 2023 78:30


    Vivianne explains how early in Alzheimer's disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Melanin-concentrating hormone and Alzheimer's disease (Nat Neurosci) Alzforum Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 40: Dopamine organizes behavior's syllables

    Play Episode Listen Later May 11, 2023 64:17


    Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Spontaneous behavior without explicit reward (Nature) Dopamine release conveys causal associations (Science) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 39: Virus-like capsids trigger paraneoplastic disease

    Play Episode Listen Later Apr 27, 2023 52:41


    Junjie from Jason's lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Junjie Xu Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Virus-like capsids in paraneoplastic disease (bioRxiv) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 38: Bacterial immunity heals sensory neurons

    Play Episode Listen Later Mar 27, 2023 64:57


    TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A. Hosts: Vincent Racaniello, Ori Lieberman, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Immunity to the microbiota promotes sensory neuron regeneration (Cell) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 37: Microglia at the crossroads

    Play Episode Listen Later Jan 23, 2023 75:05


    TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode Microglia states and nomenclature (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 36: Unbearable neurologists

    Play Episode Listen Later Jan 3, 2023 89:33


    TWiN answers listener questions about Alzheimer's disease, glaucoma and the microbiota, Dravet's Syndrome, schizophrenia, brain development, and chips implanted in the human brain. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode Letters read on TWiN 36 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 35: Neuromodulation in treatment-resistant depression

    Play Episode Listen Later Dec 6, 2022 69:13


    Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression.  Hosts: Jason Shepherd and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Closed-loop neuromodulation for depression (Nat Med) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 34: Microglia vital after spinal cord injury

    Play Episode Listen Later Sep 30, 2022 69:17


    TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Microglia coordinate spinal cord repair (Nat Commun) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 33: Viruses leaving the brain

    Play Episode Listen Later Aug 31, 2022 58:11


    TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Meningeal lymph vessels and viral exit from brain (Nature Neuroscience) Clearing mouse brain video (YouTube) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 32: Relearning how to move after stroke

    Play Episode Listen Later Aug 2, 2022 59:47


    TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together. Hosts: Ori Lieberman, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Recovery after stroke in mice (Cell Rep) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 31: HIV-1 co-receptor shapes window for memory linking

    Play Episode Listen Later Jun 29, 2022 71:52


    TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode CCR5 and memory linking (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease

    Play Episode Listen Later May 24, 2022 69:52


    TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson's disease. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Gut-brain alpha-synuclein transport in PD (Neuron) Gut has a mind of its own (Colbert Report) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 29: Astrocytes close the critical period

    Play Episode Listen Later May 2, 2022 62:05


    TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Astrocytes close the critical period (Science) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 28: Oligodendrocyte performance enhancing exosomes

    Play Episode Listen Later Apr 4, 2022 73:59


    TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Click arrow to play Download TWiN 028 (77 MB .mp3, 64 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Glia 101 (TWiN 19) Oligodendrocytes enhance axonal energy metabolism (Neuron) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 27: Eyes wired to the auditory cortex

    Play Episode Listen Later Mar 3, 2022 63:47


    TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex. Hosts: Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Remapping retinal projections (Nature) Sweet vs bitter taste (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 26: Immunological memory in the brain

    Play Episode Listen Later Jan 31, 2022 53:49


    TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses. Become a patron of TWiN! Links for this episode Memory of immunity (Cell) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 26: Immunological memory in the brain

    Play Episode Listen Later Jan 26, 2022 53:49


    TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd,  Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Memory of immunity (Cell) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 25: Thanks for listening

    Play Episode Listen Later Dec 28, 2021 62:44


    TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Males and females in neuroscience studies (New Scientist) Brain rotates memories (Quanta) Odorant receptors in brain (one, two) Neutrophils promote neuron survival (Nat Imm) Letters read on TWiN 25 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 24: Social transmission of maternal behavior with Ioana Carcea and Robert Froemke

    Play Episode Listen Later Nov 24, 2021 72:47


    Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin. Hosts: Vincent Racaniello and Timothy Cheung Guests: Ioana Carcea and Robert Froemke Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Oxytocin neurons and social transmission of behavior (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe

    TWiN 23: Peripheral nervous system with Bruce Carter

    Play Episode Listen Later Oct 31, 2021 71:20


    Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that those sensory signals are sustained as they travel long distances to the brain. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Guest: Bruce Carter Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Control of neuron survival by p75 (J Neurosci) Sympathetic nervous system (Nat Rev Neurosci) Charcot-Marie-Tooth and PMP22 protein (J Biol Chem) Satellite glial cells (Nat Rev Neurosci) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 22: It's never lupus

    Play Episode Listen Later Sep 29, 2021 68:17


    TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Lupus autoantibodies bind GluN2A-containing NMDA receptors (Nat Commun) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 21: How do we know if a mouse is hallucinating?

    Play Episode Listen Later Aug 24, 2021 88:02


    TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum. Hosts: Vincent Racaniello, Ori Lieberman, and Timothy Cheung Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Striatal dopamine and hallucination in mice (Science) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 20: Drifting aromas in the brain

    Play Episode Listen Later Jul 14, 2021 78:08


    While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Representational drift in olfactory cortex (Nature) (open preprint) Ed Yong on representational drift (Atlantic) Letters read on TWiN 20 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 19: Glia 101

    Play Episode Listen Later Jun 21, 2021 72:54


    On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 18: Autism and the gut microbiome with Mauro Costa-Mattioli

    Play Episode Listen Later May 12, 2021 70:52


    Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Mauro Costa-Mattioli Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Mauro’s work on TWiM 131 and 193 Separating genetics and microbiome in autism (Cell) Please take our listener poll Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

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