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5 episodes with retroviruses
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4 episodes with retroviruses
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4 episodes with retroviruses
2 episodes with retroviruses
3 episodes with retroviruses
Laura Waters, M.D., and Myles Helfand recap several noteworthy moments and clinically important studies from this year's Conference on Retroviruses and Opportunistic Infections (CROI 2025), which took place during a deeply uncertain moment in the HIV field, both domestically and globally. Their research conversation includes highlights in antiretroviral therapy strategies; comorbidities; emerging cure science; and prevention.¶ ¶ Access the full transcript, which includes contextual links to study abstracts and other reference info: https://www.thebodypro.com/hiv/future-hiv-care-croi-2025¶ ¶ The pod team: Our senior production manager is Alina Mogollon-Volk; our senior producer is Lizzie Warren; our associate production manager is Maui Voskova; our audio editor is Kim Buikema; and our executive producer is Myles Helfand.
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Izukanji Sikazwe, the Chief Executive Officer for the Centre for Infectious Disease Research in Zambia (CIDRZ). Dr Sikazwe joins Dr Saag to provide an overview of her symposium presentation at the 2025 Conference on Retroviruses and Opportunistic Infections (CROI) entitled Innovations in HIV Service Delivery: Building a Path Forward with Those Left Behind. Dr Sikazwe discusses her career journey in treatment of HIV in Zambia and her path to CIDRZ. Dr Sikazwe and Dr Saag discuss the history of HIV and AIDS in Zambia and address the impact that PEPFAR had on the disease when it arrived in the country in 2004. They discuss how PEPFAR has operated in Zambia and provide a current overview of the sudden cancellation of USAID contracts on those receiving HIV care and treatment and other health services. Finally, they look ahead given the current disruptions on how Zambia and other countries can move forward to meet the needs of those in need of care.0:00 – Introduction1:41 – Dr Sikazwe reviews her path to CIDRZ5:21 – History of HIV and AIDS in Zambia and discussion of stigma7:53 – The impact of PEPFAR's arrival in Zambia and Dr Sikazwe's personal history with treatment during that time13:37 – How PEPFAR works in Zambia16:56 – Impact of recent decision by the US government to cancel USAID contracts22:31 – Disruption to other health services that USAID has supported in Zambia23:50 – Response from the government in Zambia24:46 – Status of HIV in Zambia prior to cancellation of USAID contracts25:50 – The best-case scenario for people living with HIV globally and closing remarksResources: CROI 2025: https://www.croiconference.org/Centre for Infectious Disease Research in Zambia (CIDRZ): https://www.cidrz.org/ PEPFAR: https://www.state.gov/pepfar/ __________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTubeXFacebookInstagram...
This episode of Going anti-Viral, features Rebecca Denison, who gave the Martin Delaney Presentation, entitled 40+ Years of HIV: What's Changed, What Hasn't, What Shouldn't, What Must, at the 2025 Conference on Retroviruses and Opportunistic Infections (CROI). Ms. Denison is the founder of Woman Organized to Respond to Life-threatening Diseases or (WORLD). Resources: CROI 2025: https://www.croiconference.org/Woman Organized to Respond to Life-threatening Diseases or (WORLD): https://womenhiv.org/Link to video of presentation: https://youtu.be/CutIwfkv8oUMore on the Martin Delaney Presentation: https://www.croiconference.org/presenters/ __________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTubeXFacebookInstagram...
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Joseph Eron, Professor of Medicine at University of North Carolina (UNC) about the topic of his upcoming presentation at the Conference on Retroviruses and Opportunistic Infections (CROI) 2025: HIV Cure Research: State of the Art and Navigating Presentations at CROI 2025. Dr Eron discusses the state of HIV cure research including a detailed discussion of why it has been so difficult to develop a cure for HIV. Dr Saag and Dr Eron discuss the difference between HIV cure and functional cure and provide a detailed overview of cure research efforts looking at blocking and locking HIV in human DNA. Dr Saag and Dr Eron also discuss the potential for “molecular scissors” (CRISPR-Cas9) to cure HIV. Finally, they provide an overview of cure research that will be presented at CROI, highlighting the plenary presentation by Dr Ole Søgaard at CROI on Monday March 10 entitled HIV Cure: A Translational Research Perspective. For more information about the topic of this episode, listen to an earlier episode of Going anti-Viral where Dr Saag discusses Vaccine Development with Dr Richard Koup, see links in the resources below. 0:00 – Introduction1:31 – Defining cure in the context of HIV4:56 – Why is it so hard to cure HIV7:56 – What is functional cure11:47 – Description of the concept of “block and lock” in human DNA14:33 – Discussion of tat inhibitors – blocking of HIV regulatory genes18:02 – Prospect of using “molecular scissors” (CRISPR-Cas9) as a cure23:13 – Highlights in HIV cure research at CROI and closing remarksResources: CROI 2025: https://www.croiconference.org/Going anti-Viral Episode 4 – A Deep Dive into Vaccine Development with Dr Richard Koup: Apple Podcasts: https://podcasts.apple.com/us/podcast/episode-4-a-deep-dive-into-vaccine-development-with/id1713226144?i=1000637677124 YouTube: https://youtu.be/nXeMt3GMj4Q __________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTubeXFacebookInstagram...
Michael J. Corley, Ph.D., explores groundbreaking research on aging, the role of ancient viruses in our DNA, and the impact of the gut microbiome on longevity. Corley discusses how stress, diet, and exercise influence our genetic health, highlighting the complex interplay between environmental factors and our biological systems. The conversation also touches on individualized treatment strategies and the exciting potential of microbiome science in aging research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40266]
Michael J. Corley, Ph.D., explores groundbreaking research on aging, the role of ancient viruses in our DNA, and the impact of the gut microbiome on longevity. Corley discusses how stress, diet, and exercise influence our genetic health, highlighting the complex interplay between environmental factors and our biological systems. The conversation also touches on individualized treatment strategies and the exciting potential of microbiome science in aging research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40266]
Michael J. Corley, Ph.D., explores groundbreaking research on aging, the role of ancient viruses in our DNA, and the impact of the gut microbiome on longevity. Corley discusses how stress, diet, and exercise influence our genetic health, highlighting the complex interplay between environmental factors and our biological systems. The conversation also touches on individualized treatment strategies and the exciting potential of microbiome science in aging research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40266]
Michael J. Corley, Ph.D., explores groundbreaking research on aging, the role of ancient viruses in our DNA, and the impact of the gut microbiome on longevity. Corley discusses how stress, diet, and exercise influence our genetic health, highlighting the complex interplay between environmental factors and our biological systems. The conversation also touches on individualized treatment strategies and the exciting potential of microbiome science in aging research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40266]
Michael J. Corley, Ph.D., explores groundbreaking research on aging, the role of ancient viruses in our DNA, and the impact of the gut microbiome on longevity. Corley discusses how stress, diet, and exercise influence our genetic health, highlighting the complex interplay between environmental factors and our biological systems. The conversation also touches on individualized treatment strategies and the exciting potential of microbiome science in aging research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40266]
Michael J. Corley, Ph.D., explores groundbreaking research on aging, the role of ancient viruses in our DNA, and the impact of the gut microbiome on longevity. Corley discusses how stress, diet, and exercise influence our genetic health, highlighting the complex interplay between environmental factors and our biological systems. The conversation also touches on individualized treatment strategies and the exciting potential of microbiome science in aging research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40266]
Matters Microbial #81: Viruses, Innate Immunity, and Undergraduates March 5, 2025 Today, Dr. Brianne Barker, Associate Professor of the Biology Department at Drew University, joins the #QualityQuorum to discuss how her undergraduate research group studies how innate immune mechanisms of cells recognize viral invasion. Host: Mark O. Martin Guest: Brianne Barker Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A video describing the immune system, both innate and adaptive. More of a focus on mechanisms of innate immunity, the focus for today. A description of basic immune cells. An introductory video describing the viral reproductive cycle in general. A description of PRRs (pattern recognition receptors) and MAMPs (microbially associated molecular patterns) An overview of interferons and disease. An introductory video overview of programmed cell death, called apoptosis. The role that retroviruses play in producing blue eggs in chickens. Here is a very introductory summary. The role that retroviruses play in placental mammals, including humans. How do cells recognize invading DNA during viral infection? A research paper by Dr. Barker's research group. Dr. Barker on This Week in Virology. Dr. Barker's faculty website. Dr. Barker's research group website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com
In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Diane Havlir, Professor of Medicine at the University of California San Francisco. Dr Havlir currently serves as Chair of the Scientific Program Committee for the 2025 Conference on Retroviruses and Opportunistic Infections (CROI) and joins Dr Saag to provide a preview of CROI 2025. Dr Havlir provides an overview and history of CROI along with a summary of how the program is developed. Dr Saag and Dr Havlir review why CROI is unique among scientific meetings: leading scientific advances, poster sessions, and the focus on supporting new investigators. They also discuss expected hot topics from CROI such as: HIV treatment and cure, STI prevention, weight management, aging and HIV, as well as pediatric and adolescent care. Dr Saag and Dr Havlir provide an overview of resources that will be available to those who will not attend CROI in person. Finally, they discuss the value of CROI during a challenging time for all involved in the field of HIV research, care, and treatment.0:00 – Introduction1:36 – Overview and history of CROI4:12 – What makes CROI unique6:21 – Discussion of how the CROI program is developed both abstract and invited presentations11:04 – How attendees can interact at CROI12:06 – Features of poster abstract sessions and poster hall13:42 – CROI focus on new investigators17:55 – Hot topics at CROI 202520:45 – Resources for people not attending CROI22:26 – Value of CROI during a challenging time and closing remarksCROI Resources: https://www.croiconference.org/ __________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTubeXFacebookInstagram...
They say aging is just a part of life, but have you ever wondered if it really has to be? What if getting older isn't just something we accept but something we could actually treat? In this riveting episode of Peak Human Labs Podcast, Dr. Sanjeev Goel, sits down with Dr. Aubrey de Grey, a trailblazing biomedical gerontologist and Chief Science Officer of the SENS Research Foundation. They dive deep into the revolutionary idea of treating aging as a medical condition. They explore how damage accumulates in our bodies over time and discuss the groundbreaking medical advancements that could extend our healthy lifespans. Dr. de Grey sheds light on the crucial need for investing in underfunded research and shares insights into the future of longevity science. Tune in and envision a future where health and longevity are not just aspirations but achievable realities! Click HERE to sign in for Dublin Longevity Declaration. Key Takeaways Aging as a medical condition versus a natural process Mechanisms of damage accumulation in the body Concept of "longevity escape velocity" Role of epigenetic changes in aging Importance of comprehensive interventions targeting different types of damage Current state of therapies for extending human lifespan Economic implications of aging therapies and preventative medicine Research on retroviruses and chronic infections in relation to aging Innovative therapies such as hyperbaric oxygen therapy and therapeutic blood exchange The significance of personalized health approaches and the microbiome's impact on longevity In This Episode: [00:00:00] Introduction to longevity research [00:00:51] Guest introduction [00:01:17] Personal connection [00:02:04] Dr. de Grey's background [00:03:14] Early research stages [00:04:05] Understanding aging as a machine [00:05:22] Accumulated damage mechanism [00:06:15] Comprehensive medical control [00:07:13] Categories of damage [00:07:55] Wear and tear concept [00:09:20] Epigenetic changes discussion [00:11:31] Partial reprogramming concept [00:13:30] Addressing multiple mechanisms [00:14:31] Longevity escape velocity [00:15:43] Initial pushback on longevity ideas [00:17:51] Positive outlook on aging research [00:19:51] The future of longevity research [00:20:54] Funding disparities in research [00:21:10] Business models in longevity research [00:21:58] Combining existing therapies [00:23:47] Current longevity therapies [00:24:56] Caloric restriction vs. drugs [00:25:36] Dublin Longevity Declaration [00:26:39] Community building through conferences [00:28:09] Anticipating longevity breakthroughs [00:29:12] Access to longevity therapies [00:30:58] Epigenetic clocks and age reversal [00:32:24] Retroviruses and aging [00:34:56] Persistent viral infections [00:37:24] Hyperbaric oxygen therapy [00:37:49] Therapeutic blood exchange [00:39:37] Discussion on active ingredients [00:40:41] Bone marrow transplant experimentation [00:42:09] Health benefits of bone marrow transplants [00:43:05] Personal health practices [00:43:55] Advice for maximizing healthy lifespan [00:45:01] Microbiome and longevity Notable Quotes [00:03:14] "The idea that anyone could ever think that aging was just something we should accept has never made any sense to me at all." — Dr. Aubrey de Grey [00:14:31] "I believe we need to get to about 20 years of postponement of the health problems of late life, which I think we might be able to achieve in the next 12 to 15 years." — Dr. Aubrey de Grey [00:25:36] "Not only are they my favorite parts of the year, but also they are absolutely the fulcrum, the centerpiece of all of my community building effort." — Dr. Aubrey de Grey [00:43:36] "I can eat exactly what I like and nothing ever happens, and I don't even need to do any exercise and I still stay fit, so you know, don't do as I do, do as I say." — Dr. Aubrey de Grey [00:43:55] "Everybody's metabolism has its own strengths and weaknesses, and so honestly, the only generic advice that I feel that one can give in terms of maximizing one's healthy lifespan is to pay close attention to your body." — Dr. Aubrey de Grey [00:44:28] "I honestly can see a strong argument for just recommending to absolutely everybody that they should eat gluten-free food for like a fortnight, just to see whether they feel different." — Dr. Aubrey de Grey Our Guest Dr. Aubrey de Grey is a biomedical gerontologist and founder of the LEV Foundation, focused on repairing aging-related cellular damage. Based in Silicon Valley, he earned his BA in computer science and Ph.D. in biology from the University of Cambridge. His research targets the characterization and repair of aging damage. A Fellow of the Gerontological Society of America and the American Aging Association, he advises numerous journals and organizations and is a sought-after speaker at scientific and public events. Resources and Links Peak Human Labs https://www.youtube.com/@peakhumanlabs/videos https://www.peakhuman.ca/ https://www.instagram.com/peakhumanlabs/?hl=en https://open.spotify.com/show/5hx9R37ElxgzCrBccRWoHd?si=8atK0n82QbeL3DWg5-vjvg&nd=1&dlsi=ce0f77aa4f304724 Dr. Sanjeev Goel https://www.linkedin.com/in/sanjeevgoelmd/?originalSubdomain=ca Dr Aubrey de Grey https://www.levf.org/ https://www.linkedin.com/in/aubrey-de-grey-24260b/ https://web.facebook.com/aubrey.degrey/?_rdc=1&_rdr
Love it or hate it, Alien Resurrection won't be ignored. The final film in the Ripley saga of the Alien franchise (before it branched off into Predators, prequels, and other distractions…more on that below), Alien Resurrection has always been something of a hot-button issue with fans. Maybe not as much as Prometheus, but still! Any movie that deals with cloning a beloved character (who had been granted a heroic death in the previous film), complete with “genetic memories” is bound to push some buttons, but that's not even the biggest thing this movie adds to the franchise. Alien Resurrection heralds the arrival on the scene of a new kind of Xenomorph. Specifically, a human/alien hybrid made via the same shady experiments that helped “bring back” Ripley. As a result, we get a Xenomorph that (among other things) no longer lays eggs and instead can reproduce in a slightly more recognizable/mammalian fashion. And hoo-boy, do Hakeem and Tamara have questions about this one! From the handling of cloning to the hybrid alien itself, this episode of Does it Fly? is for you if the gooier corners of the Alien universe are your cup of acid blood.Check it out here or on our YouTube page!SUGGESTED VIEWING Before we get into the intricacies of the Alien franchise, allow us to also recommend one of Tamara's favorite movies, Code 46, an underrated 2003 film from director Michael Winterbottom which deals with a few similar themes of ethics within biotechnology as they regard our discussion about Alien Resurrection. Obviously, concepts from Alien Resurrection are what we focus on in this episode, but if you haven't seen the movies that precede it, too, then you might be a little lost. Those are…Alien (1979)Aliens (1986)Alien 3 (1992)Alien Resurrection (1997)Now, the franchise continues on after that, albeit to mixed (and sometimes controversial) results. Those are…Alien vs. Predator (2004)Alien vs. Predator: Requiem (2007) Both of the above movies are inessential, and take place BEFORE the events of the first film, or even the other prequels. Speaking of which, for the last decade or so, the Alien franchise has been more concerned with exploring the days before the first film, which brings us to…Prometheus (2012)Alien: Covenant (2017)And now, currently in theaters is Alien: Romulus, which takes place between Alien and Aliens. Get watchin'!FURTHER READING Do you want to delve a little deeper into the facts, concepts, and stories Hakeem and Tamara referenced in today's episode? Of course you do! CloningCentral to our discussion about the Xenomorph/human hybrid in Alien Resurrection is the question of cloning. Granted, this is a tough one to read up on, but this fact sheet from the National Human Genome Research institute is a good start. Also, doesn't the fact that there's a National Human Genome Research Institute in the first place make it sound like we're already living in a sci-fi movie?Genetic MemoryHakeem (and science in general) state that when you clone an organism, you're making a twin of it, you aren't creating an exact duplicate that also contains memories and learned experiences. That, of course, blows a pretty big hole in Alien Resurrection right out of the gate. That being said, there's some interesting reading to be done on the subject both here and here, although neither really support the movie's central premise.Hybridization“I find it really interesting that when this baby comes out and Ripley is created, both are hybrids of alien and human. So the question is, can you splice together genes like that.” For this one, we couldn't resist going back to the National Human Genome Research Institute for some hard information. See also: Retroviruses.Tuskegee Experiment 26:50One of the darker chapters of American 20th Century history involved the deliberate infection of African-Americans with syphilis in order to study the disease over a period of time. It's monstrous that something like this was sanctioned by official government agencies, and we shouldn't forget that this is part of our recent past so that it never happens again.WANT MORE FROM DOES IT FLY?Just a reminder, if you haven't watched our exploration of Xenomorph biology as it was explored in the first Alien movie (which also happens to be one of our most popular episodes), now's a good time to get to it!Check out our episode on the most infamous moment in Indiana Jones and the Temple of Doom, which just celebrated its 40th anniversary. The movie, not our episode. Oh, you know what we mean!FOLLOW US!Stay in the loop! Follow DoesItFly? on YouTube and TikTok and let us know what you think! And don't forget to follow Roddenberry Entertainment:Instagram: @RoddenberryOfficial Facebook: RoddenberryTwitter: @Roddenberry For Advertising Inquiries: doesitfly@roddenberry.com
The central focus of the Kane Lab is understanding the genetic and immunological basis for protective antiviral immune responses, as well as the molecular details underlying the direct inhibition of retroviral replication by restriction factors. Dr. Kane's lab utilizes both in vitro and in vivo tools to investigate intrinsic, innate, and adaptive immune responses to retroviral infection. The research is centered around three questions: What allows some individuals to restrict or control retroviral replication? How do retroviruses counteract host defenses? And what are the features of successful anti-retroviral immune responses?
Episode 16 - Insights on HIV Cure by Stem Cell Transplant with Dr Ravindra Gupta Recorded Live at CROI 2024 on March 3, 2024 In this episode of Going anti-Viral, Dr Michael Saag hosts Dr Ravindra Gupta. Dr Gupta is the infectious diseases expert who led the team that treated Adam Castillejo, also known as ‘The London Patient,' the second person known to have been cured of HIV. The discussion, recorded on March 3, 2024, at the Conference on Retroviruses and Opportunistic Infections (CROI), focused on the intricate process of finding a suitable stem cell donor, the immunologic and virologic considerations around the transplant process, and the collaborative medical team effort involved. 00:00 Introduction 00:30 The London Patient 03:05 Finding the CCR5∆32 Stem Cell Match 04:21 Clinical Challenges on the Transplant Journey 06:58 Post-Transplant Monitoring and Milestones 15:53 Reflecting on the Journey 18:51 Closing Thoughts and Acknowledgments__________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTube InstagramTikTok...
In this episode of Going anti-Viral, host Dr Michael Saag interviews Adam Castillejo, known as the London patient, who is the second person to have been cured of HIV infection. The discussion, recorded on March 3, 2024, at The Conference on Retroviruses and Opportunistic Infections (CROI), touches on Adam's initial HIV diagnosis in London during the early 2000s, the societal stigma and personal impact of the diagnosis, and his dual battle with HIV and cancer. Adam shares the complex journey of his treatment, including the failure of initial interventions and the ultimate success of a bone marrow transplant from a donor with a CCR5 delta 32 mutation, leading to his cure of HIV and cancer. The conversation delves into the technical aspects of bone marrow transplant, the emotional and physical challenges Adam faced during recovery, and the continued stigma he experiences even post-cure. The episode reflects on the broader implications of Adam's story for HIV research and societal perceptions of the disease.00:00 Introduction01:10 Adam's Early Struggle with HIV Diagnosis02:46 Confronting Stigma and Finding Support05:26 The Battle Against Cancer and Mental Health Challenges08:35 The Turning Point: Bone Marrow Transplant15:14 The Journey of Recovery17:29 Life After the Cure22:37 Concluding Thoughts__________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTube InstagramTikTok...
Host: Charles Flexner, MD Daily oral therapy can have low adherence, which is why the field of long-acting formulations is rapidly advancing. Tune in to hear Dr. Charles Flexner discuss how long-acting regimens can address this problem of adherence and help patients living with HIV, tuberculosis, malaria, and other infectious diseases. Dr. Flexner is a Professor of Medicine of Pharmacology, Molecular Sciences, and International Health at Johns Hopkins University, and he also presented a session on this exact topic at the 2024 Conference on Retroviruses and Opportunistic Infections.
Host: Charles Flexner, MD Daily oral therapy can have low adherence, which is why the field of long-acting formulations is rapidly advancing. Tune in to hear Dr. Charles Flexner discuss how long-acting regimens can address this problem of adherence and help patients living with HIV, tuberculosis, malaria, and other infectious diseases. Dr. Flexner is a Professor of Medicine of Pharmacology, Molecular Sciences, and International Health at Johns Hopkins University, and he also presented a session on this exact topic at the 2024 Conference on Retroviruses and Opportunistic Infections.
This week, Marianna sits down with John Faragon for the second part of our 2-part series talking all about CROI 2024, the Conference on Retroviruses and Opportunistic Infections. Learn about some of the studies that were presented, new drugs and strategies for tackling HIV, and more.--Help us track the number of listeners our episode gets by filling out this brief form! (https://www.e2NECA.org/?r=LID6457)-- Want to chat? Email us at podcast@necaaetc.org with comments or ideas for new episodes. Check out our free online courses: www.necaaetc.org/rise-coursesDownload our HIV mobile apps:Google Play Store: https://play.google.com/store/apps/developer?id=John+Faragon&hl=en_US&gl=USApple App Store: https://apps.apple.com/us/developer/virologyed-consultants-llc/id1216837691
This week, Marianna sits down with John Faragon to talk all about CROI 2024, the Conference on Retroviruses and Opportunistic Infections. Find out everything that went down from DoxyPEP data to injectable treatments and more. --Help us track the number of listeners our episode gets by filling out this brief form! (https://www.e2NECA.org/?r=WGM6434)-- Want to chat? Email us at podcast@necaaetc.org with comments or ideas for new episodes. Check out our free online courses: www.necaaetc.org/rise-coursesDownload our HIV mobile apps:Google Play Store: https://play.google.com/store/apps/developer?id=John+Faragon&hl=en_US&gl=USApple App Store: https://apps.apple.com/us/developer/virologyed-consultants-llc/id1216837691
Episode 12 - New Study on Treatments for Non-Alcoholic Fatty Liver Disease in People With HIV With Dr Jordan Lake Recorded Live from CROI 2024In this episode, Dr Michael Saag speaks with Dr Jordan Lake live from the 2024 Conference on Retroviruses and Opportunistic Infections (CROI). They discuss the prevalence of non-alcoholic fatty liver disease (NAFLD) among people with HIV and explore the effectiveness of the GLP-1 receptor agonist semaglutide, commonly used to treat diabetes and aid in weight loss, to treat NAFLD. Future areas of research are considered, including maintenance strategies post-weight loss and a placebo-controlled version of the study.00:02 Introduction and Welcome00:44 Discussion on Non-Alcoholic Fatty Liver Disease in People With HIV01:56 Role of HIV in Non-Alcoholic Fatty Liver Disease02:43 Understanding the Inflammation and Fat Accumulation in the Liver04:38 Exploring the Impact of Nucleoside Therapy on Non-Alcoholic Fatty Liver Disease06:37 Potential Treatments for Non-Alcoholic Fatty Liver Disease07:35 The Role of Semaglutide in Treating Non-Alcoholic Fatty Liver Disease13:36 The Importance of Routine Assessment for Non-Alcoholic Fatty Liver Disease15:37 Exploring New Drugs for Treating Non-Alcoholic Fatty Liver Disease18:49 The Challenges and Future Directions in Non-Alcoholic Fatty Liver Disease Research22:25 Conclusion and Closing Remarks__________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTube InstagramTikTok...
These educational podcasts will spotlight the latest advances in the treatment and prevention of HIV and related comorbidities with a series of "what you need to know" videos from data presented at CROI 2024. Launch Date: March 12, 2024Release Date: March 12, 2024Expiration Date: February 28, 2025 ACTIVITY DESCRIPTION In this podcast, Dr. Hodder will present highlights from the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) in Denver, Colorado. FACULTY BIODr. Sally Hodder is a Professor of Medicine at West Virginia University and the Associate Vice President of Clinical and Translational Research at West Virginia University Health. This podcast provides accredited continuing education credits. To qualify for credit, please read all accreditation information at the provided link below prior to listening to this episode. https://www.practicepointcme.com/CMEHome/clinical-clips174-spotlighting-hot-topics-in-hiv-independent-coverage-from-the-2024-conference-on-retroviruses-and-opportunistic-infections-1
These educational podcasts will spotlight the latest advances in the treatment and prevention of HIV and related comorbidities with a series of "what you need to know" videos from data presented at CROI 2024. Launch Date: March 12, 2024Release Date: March 12, 2024Expiration Date: February 28, 2025 ACTIVITY DESCRIPTION In this podcast, Dr. Hodder will present highlights from the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) in Denver, Colorado. FACULTY BIODr. Sally Hodder is a Professor of Medicine at West Virginia University and the Associate Vice President of Clinical and Translational Research at West Virginia University Health. This podcast provides accredited continuing education credits. To qualify for credit, please read all accreditation information at the provided link below prior to listening to this episode. https://www.practicepointcme.com/CMEHome/clinical-clips174-spotlighting-hot-topics-in-hiv-independent-coverage-from-the-2024-conference-on-retroviruses-and-opportunistic-infections-1
These educational podcasts will spotlight the latest advances in the treatment and prevention of HIV and related comorbidities with a series of "what you need to know" videos from data presented at CROI 2024. Launch Date: March 12, 2024Release Date: March 12, 2024Expiration Date: February 28, 2025 ACTIVITY DESCRIPTION In this podcast, Dr. Hodder will present highlights from the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) in Denver, Colorado. FACULTY BIODr. Sally Hodder is a Professor of Medicine at West Virginia University and the Associate Vice President of Clinical and Translational Research at West Virginia University Health. This podcast provides accredited continuing education credits. To qualify for credit, please read all accreditation information at the provided link below prior to listening to this episode. https://www.practicepointcme.com/CMEHome/clinical-clips174-spotlighting-hot-topics-in-hiv-independent-coverage-from-the-2024-conference-on-retroviruses-and-opportunistic-infections-1
These educational podcasts will spotlight the latest advances in the treatment and prevention of HIV and related comorbidities with a series of "what you need to know" videos from data presented at CROI 2024. Launch Date: March 12, 2024Release Date: March 12, 2024Expiration Date: February 28, 2025 ACTIVITY DESCRIPTION In this podcast, Dr. Hodder will present highlights from the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) in Denver, Colorado. FACULTY BIODr. Sally Hodder is a Professor of Medicine at West Virginia University and the Associate Vice President of Clinical and Translational Research at West Virginia University Health. This podcast provides accredited continuing education credits. To qualify for credit, please read all accreditation information at the provided link below prior to listening to this episode. https://www.practicepointcme.com/CMEHome/clinical-clips174-spotlighting-hot-topics-in-hiv-independent-coverage-from-the-2024-conference-on-retroviruses-and-opportunistic-infections-1
Episode 11 - Innovations in Vaccine Research: Single Cell Immunity Development With Dr Fabian Otte Recorded Live from CROI 2024In this podcast episode, Dr Michael Saag converses with Dr Fabian Otte, a molecular biologist at the University of Basel in Switzerland, live from the 2024 Conference on Retroviruses and Opportunistic Infections (CROI). Dr Otte shares insights into the ongoing development of an innovative SARS-CoV-2 vaccine that employs a single-cell immunity development approach. Highlighting its potential benefits, such as broader and longer-lasting immunity compared with mRNA vaccines. This pioneering vaccine research might also extend to other RNA viruses in the future. 00:02 Introduction to the Podcast and Guest 00:28 Discussion on the Development of Next-Generation SARS-CoV-2 Vaccines 00:50 Exploring a Single-Cell Immunity Approach 01:10 Understanding the Vaccine Development Process 02:42 The Potential of the New Vaccine 03:13 Challenges and Advantages of the New Vaccine 05:07 The Impact of the Vaccine on Immune Response__________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTube InstagramTikTok...
TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Activation of endogenous retroviruses in TBI oligodendroglia (Cell Rep) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
Chronic Fatigue Syndrome is now officially known as Myalgic Encephalomyelitis (ME/CFS). The CDC believes this is a vastly under-diagnosed condition. In this episode, you'll learn:--Why Chronic Fatigue Syndrome was a diagnosis that did not get much respect. And why the name change was encouraged by government agencies in 2015.--How the Centers for Disease Control believes that 90-95% of cases are not being diagnosed or treated properly.--That even children can be affected by ME/CFS, though it is more common in women, minorities, and those between the ages of 33 and 50.--Why a person's "phase angle" (or electromagnetic charge around the cells) can indicate the condition.--How one-fourth of those with ME/CFS are bedridden and unable to function. And how the Social Security department wanted to create more awareness of this disease because it costs between $17 and $24 billion annually.--The symptoms of ME/CFS, including: severe fatigue for at least six months, cognitive impairment, muscle or joint pain, headaches, swelling of lymph nodes, sore throat, and complete exhaustion after any kind of mental or physical work.--The underlying viral infections that can cause ME/CFS, including: Epstein-Barr virus, Lyme Disease, Rickettsia, Retroviruses, Bornaviruses, Fungi and Mycoplasma, Flu viruses, Xenotropic murine leukemia virus-related virus (XMRV), and Cytomegalovirus.--Why The Structure-Function approach used by Holistic Integration is "really the only way of getting success" with this disease process. And why there is really no effective Disease Care approach to ME/CFS.--How Homeopathy stimulates the immune system to combat the underlying viruses that cause ME/CFS. And why those with ME/CFS "do not do well" with pharmaceuticals and antibiotics.--The effectiveness of supplementation, herbals, Chiropractic adjustments, Acupuncture, and therapeutic massage for ME/CFS patients. And the importance of blood analysis every three months for these patients.www.TheVoiceOfHealthRadio.com
Get ready for an extraordinary journey into the realms of wellness, frequency-based communication, and ancient wisdom in this mind-blowing podcast episode! Michael Jaco engages in a riveting dialogue with the brilliant minds of Clayton Thomas and Sacha Stone, who unveil their profound experiences with Root Wellness and their awe-inspiring travels. Clayton takes us on a globetrotting adventure, emphasizing the significance of understanding the frequencies that connect us all. He delves into the interconnectedness of heavy metals, fungus, and parasites, unraveling the secrets hidden within our very bodies. Sacha leaves us in awe as they share the incredible recognition of Christina, the genius behind Root Wellness, by influential figures worldwide. Their support for her mission to transform the world is nothing short of remarkable. But what truly sets this conversation apart is their belief that personal choice and self-care reign supreme, transcending the chaos of external events and politics. Prepare to be mystified as they explore conversations with Kabbalistic Jews and Muslims, drawing parallels to the teachings of Moses, Mohammed, and Jesus, all speaking against idolatry. The power of bearing witness and influencing the world's outcomes is at your fingertips! The journey continues with a dive into the hidden dangers of synthetic molecules and the looming environmental apocalypse. You'll be urged to shun satanic symbols and turn your focus to family, community, and the natural world. Dr. Christina Rahm, Jim Humble, and even the Vatican take center stage in a captivating narrative of restoring ancient protocols. But it doesn't stop there. Retroviruses in Wuhan, reptilians in tunnels, and an unwavering commitment to humanity's well-being are all part of their compelling story. Discover the groundbreaking products they've developed, each with intentional names like Clean Slate Zero and Restore. Case studies on reversing aging, featuring biblical components, will leave you in awe. The conversation takes a deep dive into the necessity of protective barriers against environmental toxins, the brilliance of Dr. Rahm, and the magic of restructuring water to transform your very being. Join us for an epic episode filled with wisdom, wonder, and a profound commitment to injecting money back into good causes. You won't want to miss this awe-inspiring discussion that may just change the way you view the world and your place in it! Join host Michael Jaco, Ex-Navy Seal, who teaches you how to tap into your Intuition and Unleash the Power within, so you can become the Master of your Reality. To get behind the scenes access to Michael Jaco's videos join his Intuitive Warrior club here - michaelkjacosocial.com Connect with Michael Jaco go to his website - michaelkjaco.com Sacha Stone https://sachastone.com/about/ Clayton Thomas https://theclaytonthomas.com Root Brands Wellness Reverse the affects of the vaccines, shedding, and toxin dumps plus fortify your system to survive and thrive with a Life enhancing "natural product line" by cutting edge Dr. Christina Rahm. Designed to heal and enhance natural health: Root Wellness use "Jaco" to activate your own personal account to order and create your own code to share and grow your own success at checkout: https://therootbrands.com/jaco
In today's Cleanse Heal Ignite episode with Dr Diane Kazer, Warrior Wednesdays to help you become your own best doctor, we're going to talk about Advanced Medical Treatments such as Lasik, Stem Cell, EDTA, IV's and more + Cleaning Up the Root Cause - Toxins such as Hydrogels, Graphene Oxide, Forever Chemicals, Microplastics & More! Prepare to be INpowere'ed and INspired. Tune in LIVE Wednesday July 12, from 10-11am PT on Dr Kazer's Channel on CloutHub, Twitter or Rumble to learn about: Advanced Medical Treatments - Lasik, Stem Cell, EDTA, IV's? Cleaning it all up - Hydrogels, Graphene Oxide, Forever Chemicals, Nanobots, Parasites, Microplastics, Retroviruses, and more! ‘Spike Protein' & Detox Supplements won't work Unless you focus on this one thing The #1 class of toxins responsible for Cancer, Weight Gain, Gender Confusion, Fatigue, Hormonal Chaos, Immunity Crashes and Total System Failure of the Body! Plastic Planet = Prison Planet - What are Microplastics and why must you clear them from your field NOW We will specifically focus on the most urgent and imperative action steps Dr Kazer advises ALL Americans and all humans to work on a Total Body Transformation approach to Cleanse your Body, Heal the Root Cause and Ignite your Sovereignty from symptoms, sickness and suffering. http://dianekazer.com/vip https://shop.dianekazer.com http://dianekazer.towergarden.com https://www.ewg.org/tapwater/ See you there?
Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Kevin Ng Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Antibodies against ERVs and lung cancer (Nature) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
This week, we're sitting down with John Faragon the final installment of our 3-part series covering the Conference on Retroviruses and Opportunistic Infections - or CROI – which took place in February 2023. Learn about some of the key studies discussed, investigational medications for HIV, and more. --Help us track the number of listeners our episode gets by filling out this brief form! (https://www.e2NECA.org/?r=LXG4838)
This week, we're sitting down with John Faragon for part two of our series covering the Conference on Retroviruses and Opportunistic Infections - or CROI – which took place in February 2023. Learn about the latest in regards to HIV prevention data, treatment, and more. --Help us track the number of listeners our episode gets by filling out this brief form! (https://www.e2NECA.org/?r=CQX4820)
This week, Marianna sits down with John Faragon to talk all things CROI 2023. CROI is the Conference on Retroviruses and Opportunistic Infections, which took place in February 2023. Find out what happened, what you may have missed, and why it matters for your as an HIV care provider. --Help us track the number of listeners our episode gets by filling out this brief form! (https://www.e2NECA.org/?r=XJM4792)
Episode 12 features an interview with Jim Pickett and his participaron in the Conference on Retroviruses and Opportunistic Infections CROI that took place in Seattle, Washington from February 19 – 22. Jim Pickett facilitates the Margarita Breakfast Club, a webinar style daily event prior to the commencement of the plenaries where scientist and researchers are invited to present their research to the community.
Conference clinical cochair Diane Havlir, MD, a professor of medicine at the University of California, San Francisco, sits down with JAMA Deputy Editor Preeti Malani, MD, MSJ, about research highlights presented at the 30th annual CROI, held in Seattle. The infectious disease experts discuss postexposure prophylaxis for sexually transmitted infections, a new protease inhibitor for COVID-19, goals for preventing HIV transmission, and more. Related Content: Highlights From CROI, the Conference on Retroviruses and Opportunistic Infections—Postexposure Prophylaxis for Sexually Transmitted Infections, a New Protease Inhibitor for COVID-19, Goals for Preventing HIV Transmission, and More
Join Ben Plumley and Yvette Raphael, live from CROI 2023 (the Conference on Retroviruses and Opportunistic Infections - THE conference for the latest science on viruses, bacteria and other pandemic threats), as they profile the data they want to learn about - from HIV prevention, treatment and cure, to Mpox, COVID and other bugs - as well as Yvette's opening plenary speech on the leadership of women scientists, doctors and community advocates - and she has A LOT to say! https://www.croiconference.org https://www.ashotinthearmpodcast.com https://www.niaid.nih.gov https://www.cdc.gov https://www.iasusa.org https://www.unaids.org https://www.state.gov/pepfar #CROI_2023 #HIV #Mpox #COVID #MABs #longacting #prevention #treatment #vaccine #pandemics
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.27.525863v1?rss=1 Authors: Cocozza, F., martin jaular, l., lippens, l., di cicco, a., arribas, y. a., dingli, f., richard, m., merle, l., Poullet, P., loew, d., Hendrix, A., Kassiotis, G., joliot, a., tkach, m., Thery, C. Abstract: Cells secrete membrane-enclosed extracellular vesicles (EVs) and non-vesicular nanoparticles (ENPs) that may play a role in intercellular communication. Tumor-derived EVs have been proposed either to induce immune priming of antigen presenting cells, or to be immuno-suppressive agents promoting tumor immune escape. We suspect that such disparate functions are due to variable composition in EV subtypes and ENPs of the analyzed EV preparations. We aimed to exhaustively characterize the array of secreted EVs and ENPs of murine tumor cell lines. Unexpectedly, we identified virus-like particles (VLPs) from endogenous murine leukemia virus in preparations of EVs produced by tumor cells. We established a robust protocol to separate small (s)EVs from VLPs and ENPs. We compared their protein composition and analyzed their functional interaction with target dendritic cells (DCs). ENPs were poorly captured and did not affect DCs. sEVs specifically induced DC death. A mixed EV/VLP preparation was the most efficient to induce DC maturation and antigen presentation. Our results call for systematic re-evaluation of the respective proportions and functions of non-viral EVs and VLPs produced by tumors and their contribution to anti-tumor immune responses and to tumor progression. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
I got the opportunity to talk to former NIH Director and 1989 Nobel Prize Winner of Physiology or Medicine, Dr Harold Varmus. ---------------------------------------------------- Thanks to the partners: Newsly: https://newsly.mepromo code: EARLYMORNING. Anchor https://anchor.fm Libysn https://libsyn.compromo code: DG Hardsnake Energy https://www.instagram.com/hardsnakenrgy spikeview https://www.spikeview.comhttps://www.instagram.com/spikeview ---------------------------------------------------------------------------------- Listen on: Podcast website: https://anchor.fm/diamondgoat Spotify: https://open.spotify.com/show/0EuhA6WyuerHtVAqcFrFeO Google Podcast: https://www.google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy80NzE4MzM5MC9wb2RjYXN0L3Jzcw== RadioPublic: https://radiopublic.com/dg-earlymorning-show-WoML4r Breaker: https://www.breaker.audio/dg-early-morning-show Podcast YT channel clips: https://www.youtube.com/channel/UCPZdwPiE-Rb7yv0qQ_7Nqpw Reason: https://reason.fm/podcast/dg-earlymorning-show Apple Podcast: https://podcasts.apple.com/us/podcast/dg-early-morning-show/id1575451533 Amazon Music: https://music.amazon.com/podcasts/f050b86c-1dad-4bc3-b12f-6aa5fa62438c -------------------------------------- Check out my other stuff: Instagram: @itzdiamondgoat Twitter: https://twitter.com/lildiamondgoat Main YT channel: youtube.com/diamondgoat Main Tiktok: @lildiamondgoat Second Tiktok: @lildiamondgoatextra Soundcloud: @Lil Diamondgoat Spotify: @Lil Diamondgoat Merch store: https://diamondgoat.creator-spring.com --- Support this podcast: https://podcasters.spotify.com/pod/show/diamondgoat/support
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.07.506982v1?rss=1 Authors: Garza, R., Sharma, Y., Atacho, D., Hamdeh, S. A., Jonsson, M. E., Ingelsson, M., Jern, P., Hammell, M. G., Englund, E., Jakobsson, J., Marklund, N. Abstract: Traumatic brain injury (TBI) is a leading cause of persistent functional brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. Here, we used single-nuclei RNA-sequencing to study transcriptomic changes in different cell populations from human brain tissue obtained acutely after severe, life-threatening TBI. We found a unique transcriptional response in several cell types, including the activation of an interferon response in oligodendrocytes coupled with the transcriptional activation of MHC-class I and class II related genes. Thus, oligodendrocytes undergo a transformation to an immune-like cell state immediately after TBI, indicating an important role for these cells in the initiation of neuroinflammation. Notably, the activation of immune-related genes correlated with the expression of endogenous retroviruses in oligodendrocytes, linking these ancient viral sequences to neuroinflammation. In summary, this work provides a unique insight into the initiating events of the neuroinflammatory response in TBI, which has new therapeutic implications. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.29.505641v1?rss=1 Authors: Newman, A. G., Sharif, J., Bessa, P., Zaqout, S., Brown, J., Nakayama, M., Mueller, S., Böhm-Sturm, P., Ohara, O., Koseki, H., Singh, P., Tarabykin, V. Abstract: In aging cells and animal models of premature aging, heterochromatin loss coincides with the transcriptional activation of normally silenced endogenous retroviruses (ERVs). Here we show that loss of heterochromatin maintenance and de-repression of ERVs results in neurodegeneration via the Complement cascade in an age dependent manner. We discovered differential contributions of HP1 proteins to ERV silencing where HP1{gamma} is necessary and sufficient for H4K20me3 deposition and HP1{beta} deficiency is detrimental to DNA maintenance methylation. Progressive ERV de-repression in HP1{beta}/{gamma} DKO mice was followed by stimulation of the integrated stress response, the induction of Complement 3+ reactive astrocytes and increased infiltration and activation of microglia. This chronic inflammatory state coincided with age-dependent reductions in dendrite complexity and cognition. Our results demonstrate the importance of preventing loss of epigenetic maintenance, as this will be the only way postmitotic neuronal genomes can be protected and/or renewed. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
KSQD 5-04-2022: (Archive show) Review of genetics research focusing on genetic diseases: sickle cell, Huntingtons, fragile X syndrome, cystic fibrosis, breast cancer, Tay-Sachs, tuberculosis, Creutzfeldt–Jakob disease and prions; More genetics topics such as repetitive DNA, transposons, jumping genes, oncogenes and retroviruses
Upon sequencing the human genome, scientists were surprised to find that it is composed of about 8% viral sequence. These fossils are relics of ancient primate infections where retroviruses incorporated into the chromosome and became part of the human lineage. While these viral elements have contributed positively to speciation and development of specific human traits, they also have the capacity to become pathogenic. Dr. Advinda Nath is the Clinical Director of the National Institute of Neurological Disorders and Stroke. He joins Talking Biotech to share his experiences, knowledge and predictions in this exciting, emerging area of research. # COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab's world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.
Jesús Martin-Garcia is the CEO of GeNeuro, a Swiss-based clinical stage company focused on novel approaches for treating autoimmune and neurodegenerative diseases. While previously considered junk DNA, human endogenous retroviruses are now being seen in a new light as they represent 8% of human DNA and play a role in locking viral reproduction. Jesús explains, "Our mission is really to focus on and to defeat neurodegenerative diseases. We have an original approach, and we believe because we are based on leveraging the biology of human endogenous retroviruses, which are the traces that are left in our DNA by the virus contaminations that affected our ancestors. We believe they play a major role in neurodegenerative diseases, such as multiple sclerosis, ALS, and now recent data has shown, long-COVID." "Yes, that was frankly a surprise for us. It was a discovery led by some academic groups in the US and Europe that showed that SARS-CoV-2, remember I told you at the beginning, this interaction between exogenous viruses in our cells, and the fact that some of them were able to de-repress pathogenic proteins. SARS-CoV-2 was shown to be able to de-repress W-ENV, which is basically the same protein that we see in the brain of MS patients. But this time, it was really, I would say a more diverse de-repression - a stronger expression in lymphocytes in the blood, on endothelial cells of the brain, the heart, and the lung, and also all the way up to microglia, the brain, in some patients that had died from COVID." @GeneuroO #Geneuro #Temelimab #HERVs #LongCOVID #ALS #MS #MultipleSclerosis #NIH #Retroviruses Geneuro.com Download the transcript here
Jesús Martin-Garcia is the CEO of GeNeuro, a Swiss-based clinical stage company focused on novel approaches for treating autoimmune and neurodegenerative diseases. While previously considered junk DNA, human endogenous retroviruses are now being seen in a new light as they represent 8% of human DNA and play a role in locking viral reproduction. Jesús explains, "Our mission is really to focus on and to defeat neurodegenerative diseases. We have an original approach, and we believe because we are based on leveraging the biology of human endogenous retroviruses, which are the traces that are left in our DNA by the virus contaminations that affected our ancestors. We believe they play a major role in neurodegenerative diseases, such as multiple sclerosis, ALS, and now recent data has shown, long-COVID." "Yes, that was frankly a surprise for us. It was a discovery led by some academic groups in the US and Europe that showed that SARS-CoV-2, remember I told you at the beginning, this interaction between exogenous viruses in our cells, and the fact that some of them were able to de-repress pathogenic proteins. SARS-CoV-2 was shown to be able to de-repress W-ENV, which is basically the same protein that we see in the brain of MS patients. But this time, it was really, I would say a more diverse de-repression - a stronger expression in lymphocytes in the blood, on endothelial cells of the brain, the heart, and the lung, and also all the way up to microglia, the brain, in some patients that had died from COVID." @GeneuroO #Geneuro #Temelimab #HERVs #LongCOVID #ALS #MS #MultipleSclerosis #NIH #Retroviruses Geneuro.com Listen to the podcast here
A cquired immunodeficiency syndrome (AIDS) Awas first reported in 1981 in'homosexual men. AIDS is a retroviral disease caused by human immunodeficiency virus (HlV). The disease is characterized by immunosuppression, secondary neoplasma and neurological manifestations. AIDS is invariably fatal since there is no cure. In the USA, it is the fourth leading cause of death in men between the ages 15 to 55 years. No other disease has attracted as much aftention as AIDS by the governments, public and scientists. AIDS has stimulated an unprecedented amount of biomedical research which led to a major understanding ofthis deadfy disease within a short period of time. So rapid is the research on AIDS (particularly relating to molecular biofogy), any review is destined to be out of date by the time it is published! The isolation of human immunodeficiency virus (HIV) from lymphocytes of AIDS patients was independently achieved by Gallo (USA) and Montagnier (France) in 1984. Epidemiology AIDS was first described in USA and this country has the majority of reported cases. The prevalence of AIDS has been reported from almost every country. The number of people living with HfV worldwide is estimated to be around 40 million by the end of the year 2005. (lndia alone has about 5 million persons). At least 5 million deaths occurred in 2005, due to AIDS. AIDS is truely a global disease with an alarming increase in almost every country. Transmission of HIV : Transmission of AIDS essentially requires the exchange of body fluids (semen, vaginal secretions, blood, milk) containing the virus or virus-infected celfs. There are three major routes of HIV transmission- sexual contact, parenteral inoculation, and from infected mothers to their newborns. The distribution of risk factors for AIDS trans- mission are as follows. Sex between men (homosexuals) Sex between men and women - 60"/" -15%Intravenous drug abusers - 15"/" Transfusion of blood and blood products - 6% All others - 4o/o The predominant methods of HIV transmission (about 75o/") are through anal or vaginal intercourse. The risk for the transmission is much higher with anal than with vaginal intercourse. The practice of 'needle sharing' is mainly responsible for the transmission of HIV in drug abusers. Pediatric AIDS is mostly caused by vertical transmission (mother to infant). It should, however, be noted that HIV cannot be transmitted by casual personal contact in the household or work place. Further, the transmission of AIDS from an infected individual to health personnel attending on him is extremelv rAre. Virology of HIV AIDS is caused by a retrovirus, namely human immunodeficiency virus (HlY), belonging to lentivirus family. Retroviruses contain RNA as the genetic material. On entry into the host cell, they transcribe DNA which is a complementary copy of RNA. The DNA, in turn is used, as a template to produce new viral RNA copies. Two different forms of HlV, namely HIV-I and HIV-2 have been isolated from AIDS patients. HIV-1 is more common, being found in AIDS patients of USA, Canada, Europe and Central Africa while HIV-2 is mainly found in West Africa. Both the viruses are almost similar except they differ in certain immunological properties. HIV-1 is described in some detail. Structure of HIV : The viruse is spherical with a diameter of about 110 nm. lt contains a core, surrounded by a lipid envelop derived from the host pfasma membrane (Fig.3fl.l). The core of the HIV has two strands of genomic RNA and four core proteins, PZq, PtB, reverse tranScriptase (poolpsr) and endonuclease (p32). Note that the naming of the proteins is based on the molecular weight. For instance, a protein with a molecular weight of 24,0OO is designated as p2,4. The lipid membrane of the virus is studded with two glycoproteins Bprzo and gpot. The surface antigen 8p126 is very important for the viral infection CD4.
What are Endogenous Retroviruses? Where do they come from? And what can they tell us about our past? The guys discuss this, and for some unknown reason, Chris decides to talk about the Queen's Birthday Holiday. See omnystudio.com/listener for privacy information.
This week, we sit down with John Faragon to talk all about the latest update from CROI, the Conference on Retroviruses and Opportunistic Infections. Learn all about the latest in COVID treatment, COVID disparities in care, new HIV medications, and PrEP. (Help us track how many listeners our episode gets by filling out this brief form!)
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