Podcasts about Lewy

Play Episode Listen Later Nov 13, 2022

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.11.516171v1?rss=1 Authors: Leyns, C. E. G., Prigent, A., Beezhold, B., Yao, L., Hatcher, N., Tao, P., Kang, J., Suh, E., Van Deerlin, V. M., Trojanowski, J. Q., Lee, V. M. Y., Kennedy, M., Fell, M., Henderson, M. X. Abstract: Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases characterized by the accumulation of misfolded -synuclein in the form of Lewy pathology. While most cases are sporadic, there are rare genetic mutations that cause disease and more common variants that increase incidence of disease. The most prominent genetic mutations for PD and DLB are in the GBA1 and LRRK2 genes. GBA1 mutations are associated with decreased glucocerebrosidase activity and lysosomal accumulation of its lipid substrates, glucosylceramide and glucosylsphingosine. Previous studies have shown a link between this enzyme and lipids even in sporadic PD. However, it is unclear how the protein pathologies of disease are related to enzyme activity and glycosphingolipid levels. To address this gap in knowledge, we examined quantitative protein pathology, glucocerebrosidase activity and lipid substrates in parallel from 4 regions of 91 brains with no neurological disease, idiopathic, GBA1-linked, or LRRK2-linked PD and DLB. We find that several biomarkers are altered with respect to mutation and disease severity. We found mild association of glucocerebrosidase activity with disease, but a strong association of glucosylsphingosine with 8-synuclein pathology, irrespective of genetic mutation. This association suggests that Lewy pathology precipitates changes in lipid levels related to disease severity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

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Episode 65: Holiday Survival Strategies for Dementia Caregivers

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Play Episode Listen Later Nov 6, 2022 53:39

Holiday season is busy. Even busier if you care for someone living with dementia. In this episode, you will learn helpful strategies for navigating holiday parties and religious celebrations. I provide all purpose "scripts" for dealing with long-distance relatives and uninvolved family members who criticize your care in the form of "concern." Whether you spin the #dreidel, dance around the #Yule log, decorate the #Christmas tree, or burn the #Kwanzaa candles--this podcast is for you! Make Dementia Your B*tch podcast has been selected by Feedspot as one of the Top 25 Dementia Podcasts for 2022—check it out: https://blog.feedspot.com/dementia_podcasts/ Free VIRTUAL dementia education and support session calendar: https://dementiacentricsolutionsllc.clickmeeting.com/monthly-dementia-webinars Other resources: New! 5 Ways to help People living with dementia who refuse help: https://dementiacentricsolutions.com/caring-for-someone-living-with-dementia-tired-of-fighting-and-arguing/ Have a question? Want more information about my programs? Email me: dr.rita.jablonski@gmail.com Interested in my book? Get your free preview here: https://read.amazon.com/kp/embed?asin=B09SR2ZMM2&preview=newtab&linkCode=kpe&ref_=cm_sw_r_kb_dp_1984RXHNZ8WBNHR7WSJ2 You can also leave questions here: https://anchor.fm/rita-a-jablonski/message #alzheimers #dementia #caregiving #behaviors #dementiabitch #Lewy body #Parkinsons #vascular #care refusals #apathy #holidays --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/rita-a-jablonski/message

In vivo 18F-DOPA PET imaging identifies a dopaminergic deficit in a rat model with a G51D α-synuclein mutation

Play Episode Listen Later Nov 5, 2022

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.05.515268v1?rss=1 Authors: Morley, V., Singh-Dolt, K., Alcaide-Corral, C. J., Walton, T., Lucatelli, C., Mashimo, T., Tavares, A., Kunath, T. Abstract: Parkinsons disease (PD) is a neurodegenerative condition with several major hallmarks, including loss of substantia nigra neurons, reduction in striatal dopaminergic function, and formation of alpha-synuclein-rich Lewy bodies. Mutations in SNCA, encoding for alpha-synuclein, are a known cause of familial PD, and the G51D mutation causes a particularly aggressive form of the condition. CRISPR/Cas9 technology was used to introduce the G51D mutation into the endogenous rat SNCA gene. SNCAG51D/+ and SNCAG51D/G51D rats were born in Mendelian ratios and did not exhibit any severe behavourial defects. L-3,4-dihydroxy-6-18F-fluorophenylalanine (18F-DOPA) positron emission tomography (PET) imaging was used to investigate this novel rat model. Wild-type (WT), SNCAG51D/+ and SNCAG51D/G51D rats were characterised over the course of ageing (5, 11, and 16 months old) using 18F-DOPA PET imaging and kinetic modelling. We measured the influx rate constant (Ki) and effective distribution volume ratio (EDVR) of 18F-DOPA in the striatum relative to the cerebellum in WT, SNCAG51D/+ and SNCAG51D/G51D rats. A significant reduction in EDVR was observed in SNCAG51D/G51D rats at 16 months of age indicative of increased dopamine turnover. Furthermore, we observed a significant asymmetry in EDVR between the left and right striatum in aged SNCAG51D/G51D rats. The increased and asymmetric dopamine turnover observed in the striatum of aged SNCAG51D/G51D rats is similar to prodromal PD, which suggests the presence of compensatory mechanisms. SNCAG51D rats represent a novel genetic model of PD, and kinetic modelling of 18F-DOPA PET data has identified a highly relevant early disease phenotype. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

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Episode 64: Apathy in Different Dementias

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Play Episode Listen Later Nov 2, 2022 25:13

One of the most frustrating aspects of dementia is when the person living with dementia has no motivation to do anything. This extreme lack of motivation is called apathy. Apathy has different causes in people living with bvFTD than people with other dementias. In today's podcast, I'm going to explain what causes apathy depending on the type of dementia and, as I always do, will provide some approaches to successfully handle apathy. Want to hear me LIVE? If you live in the Anniston Alabama area, I will be speaking on November 4 at the Annual Caregiver Conference. Here is the link to register (it is free!): https://www.eastalabamaaging.org/4th-annual-caregivers-conference-caregiving-around-the-clock/ Make Dementia Your B*tch podcast has been selected by Feedspot as one of the Top 25 Dementia Podcasts for 2022—check it out: https://blog.feedspot.com/dementia_podcasts/ Free VIRTUAL dementia education and support session calendar: https://dementiacentricsolutionsllc.clickmeeting.com/monthly-dementia-webinars Other resources: New! 5 Ways to help People living with dementia who refuse help: https://dementiacentricsolutions.com/caring-for-someone-living-with-dementia-tired-of-fighting-and-arguing/ Have a question? Want more information about my programs? Email me: dr.rita.jablonski@gmail.com Interested in my book? Get your free preview here: https://read.amazon.com/kp/embed?asin=B09SR2ZMM2&preview=newtab&linkCode=kpe&ref_=cm_sw_r_kb_dp_1984RXHNZ8WBNHR7WSJ2 You can also leave questions here: https://anchor.fm/rita-a-jablonski/message #alzheimers #dementia #caregiving #behaviors #dementiabitch #Lewy body #Parkinsons #vascular #care refusals #apathy --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/rita-a-jablonski/message

Et si l'intelligence artificielle pouvait aider à diagnostiquer les maladies neurodégénératives ?

Choses à Savoir CERVEAU

Play Episode Listen Later Oct 30, 2022 2:34

Les maladies neurodégénératives telles que la maladie d'Alzheimer, la maladie de Parkinson ou encore la maladie à corps de Lewy touchent des millions de personnes à travers le monde. S'il n'existe malheureusement aucun traitement permettant de guérir de ces pathologies, des approches et prises en charges adéquates permettent de ralentir l'évolution irrémédiable de ces maladies offrant ainsi des années d'autonomie et de vie supplémentaires. Mais pour que ces traitements puissent réellement avoir une prise sur l'évolution de ces pathologies, il apparait qu'un diagnostic le plus précoce possible est l'une des clés de cet efficacité. Or, le diagnostic des maladies neurodégénératives n'est pas facile à poser et celui-ci peut fréquemment arriver une fois que la pathologie a largement progressé. Learn more about your ad choices. Visit megaphone.fm/adchoices

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Episode 63: Why Does My Family Member's Dementia Look Differently? Cognitive Reserve

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Play Episode Listen Later Oct 25, 2022 20:02

Why does my family member's dementia look differently from others with the same diagnosis, or even at the same stages? I get this question multiple times a week. Sometimes, caregivers are confused because this is the second, or third, person they are caring for…and their experience this time is very different from earlier experiences. Or, a caregiver is going to a support group and realizes that their loved one's memory problems are not consistent with what other members are describing. Caregivers start to wonder if the person living with dementia is “pretending” to have memory problems or if the diagnosis is correct. Some caregivers may even believe that their family member could do more if only they would try harder. One reason why two people with the same diagnosis may behave differently is because of something called “cognitive reserve.” Cognitive reserve is the build up of extra neurons in different parts of the brain. Education, hobbies, and occupation can all build cognitive reserve. Make Dementia Your B*tch podcast has been selected by Feedspot as one of the Top 25 Dementia Podcasts for 2022—check it out: https://blog.feedspot.com/dementia_podcasts/ Free VIRTUAL dementia education and support session calendar: https://dementiacentricsolutionsllc.clickmeeting.com/monthly-dementia-webinars Other resources: New! 5 Ways to help People living with dementia who refuse help: https://dementiacentricsolutions.com/caring-for-someone-living-with-dementia-tired-of-fighting-and-arguing/ Have a question? Want more information about my programs? Email me: dr.rita.jablonski@gmail.com Interested in my book? Get your free preview here: https://read.amazon.com/kp/embed?asin=B09SR2ZMM2&preview=newtab&linkCode=kpe&ref_=cm_sw_r_kb_dp_1984RXHNZ8WBNHR7WSJ2 You can also leave questions here: https://anchor.fm/rita-a-jablonski/message #alzheimers #dementia #caregiving #behaviors #dementiabitch #Lewy body #Parkinsons #vascular #care refusals #cognitive reserve --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/rita-a-jablonski/message

Alzheimer's and Dementia Types

Answers For Elders Radio Network

Play Episode Listen Later Oct 22, 2022 12:01

Kelley Smith at CarePartners Senior Living joins Suzanne to talk about different types of dementia, and how to approach caring for a senior loved one. If you contact the Alzheimer's Association, they'll tell you there are over a hundred different types of dementia. Alzheimer's is the kind of dementia you see the most, and you also see vascular dementia that can be brought on by a number of different things. Heart disease, COPD. You also see Lewy body dementia, which unfortunately is very common with many Parkinson's residents. You don't have to have Parkinson's to get Lewy body, but that also forms a very different behavior, a very different outlook. Also, a 45 year old person who gets Alzheimer's will probably be deceased by 50, and an 89 year old woman's with Alzheimer's will probably live out their life. We as family members think we're doing right by a loved one because we have them at home, but we really are clueless when it comes to communication. We don't know how to stimulate their brains — we don't have those skill sets. What should they expect in a home care situation? You need to take a look at the situation. If your loved one is still safe at home — they're not wandering, they're not at risk, they're still in the first stages — can you bring in some home care to kind of help out with a few things, maybe some housekeeping, whatever it takes to keep them at home? As long as they're safe at home, it's never a bad idea. When we get to the dementia part, where we have science experiments in the refrigerator and medication not being taken on time, then it's time to ask: Is it really realistic for us to keep mom and dad at home? What's it doing to my health, what's it doing to our situation? And is it working? Is mom happy? And if the truth is it's not working, she's not happy, then you have to start looking at some outside options. And there's adult family homes, there's assisted living, memory care-type communities, there are options out there. But you have to figure out what's going to be best for them with their personality and their abilities, and their social skill at the time that the placement has become necessary. In the next segment, Kelley and Suzanne talk about various care options for those with Alzheimer's and dementia. Learn more at CarePartners' website.

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Episode 86: Robin Williams / Lewy Body Dementia

Doctor Vs Comedian

Play Episode Listen Later Oct 21, 2022 54:44

Today, Ali and Asif discuss the career of the legendary actor and comedian Robin Williams. The guys start off by discussing their early exposure to Robin Williams including ‘Popeye', ‘Mork and Mindy' Robin's early HBO specials (including Comic Relief). They then discuss some interesting facts about Robin's early life. They go over some interesting trivia about Robin, his pivotal movies and his legacy in stand-up comedy. Then Ali asks Asif about Dementia with Lewy Bodies, which Robin suffered from. Asif starts off by defining what Lewy Bodies are and their connection to dementia and Parkinson's disease. They then discuss the symptoms Robin suffered from and how these symptoms (retrospectively) fit completely the criteria for Dementia with Lewy Bodies. The opinions expressed are those of the hosts, and do not reflect those of any other organizations. This podcast and website represents the opinions of the hosts. The content here should not be taken as medical advice. The content here is for entertainment and informational purposes only, and because each person is so unique, please consult your healthcare professional for any medical questions. Music courtesy of Wataboi and 8er41 from Pixabay Contact us at doctorvcomedian@gmail.com Follow us on Social media: Twitter: @doctorvcomedian Instagram: doctorvcomedian Show Notes: Robin Williams: Come Inside My Mind: https://www.hbo.com/movies/robin-williams-come-inside-my-mind Knowing: Robin Williams: https://podcasts.apple.com/ca/podcast/knowing-robin-williams/id1482972205 Robin's Wish review – sad salute to a master comedian: https://www.theguardian.com/film/2020/dec/30/robins-wish-review-robin-williams Robin Williams's widow: 'There were so many misunderstandings about what had happened to him: https://www.theguardian.com/film/2021/jan/01/robin-williamss-widow-there-were-so-many-misunderstandings-about-what-had-happened-to-him The terrorist inside my husband's brain: https://n.neurology.org/content/neurology/87/13/1308.full.pdf Diagnosis and management of dementia with Lewy bodies: https://n.neurology.org/content/89/1/88 Dementia with Lewy bodies: an update and outlook: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341685/ Lewy body disease or diseases with Lewy bodies? https://www.nature.com/articles/s41531-021-00273-9

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Grandpa & Lewy – A Children's Book of Hope and Understanding

Alzheimer's Speaks Radio - Lori La Bey

Play Episode Listen Later Oct 21, 2022 55:00

Lori La Bey talks with Jennifer Randazzo, author of Grandpa & Lewy: A Story of Hope and Empowerment for Children Touched by Lewy Body Dementia. Her own father battle Lewy body dementia. Jennifer was determined to raise awareness and provide a resource that her family never had. Join Lori and listen to Jennifer's story. By sharing experiences and tools we make the journey easier for everyone. Contact Jennifer Randazzo Website Email Instagram Facebook Pinterest Twitter @JRandazzoAuthor Linkedin @Jennifer Randazzo Contact Lori La Beywith questions or visit www.AlzheimersSpeaks.com Alzheimer's Speaks Radio - Shifting dementia care from crisis to comfort around the world one episode at a time by raising all voices and delivering sounds news, not just sound bites since 2011.

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Dispelling Brain Health Misunderstandings: A Response to Joe Rogan and Max Lugavere

Brain Health and Beyond with Team Sherzai, MD

Play Episode Listen Later Oct 17, 2022 169:58 Very Popular

This episode is dedicated to clarification of a podcast between Joe Rogan and Max Lugavere, two popular influencers that have a large audience. They discussed Alzheimer's disease and brain health in general and some of the information that was shared was not accurate, which can be really harmful. This is by no means an attack on Rogan or Lugavere. After listening to the conversation, we think Lugavere may not be quite familiar with the data regarding brain health, and it would be important to set the record straight and share the evidence with people and let them decide what's best for them. Having seen thousands of patients with dementia, whether it's Alzheimer's disease, frontotemporal lobe dementia, Lewy Body Dementia and others, we feel it's our responsibility to share evidence based data as opposed to feel-good, self confirming anecdotes. Relevant references: Ketogenic Diet: Phillips, M. C et al. (2021). Randomized crossover trial of a modified ketogenic diet in Alzheimer's disease. Alzheimer's research & therapy, 13(1), 1-12. Lilamand, M et al. (2022). Efficacy and Safety of Ketone Supplementation or Ketogenic Diets for Alzheimer's Disease: A Mini Review. Frontiers in Nutrition, 1324. Włodarek, D. (2021). Food for thought: the emerging role of a ketogenic diet in Alzheimer's disease management. Expert Review of Neurotherapeutics, 21(7), 727-730. Cronjé, H et al. (2021). Ketogenic therapies in mild cognitive impairment and dementia. Current Opinion in Lipidology, 32(5), 330-332. LDL Cholesterol metabolism and risk of Alzheimer's: Andrews, S et al., collaborators of the Alzheimer's Disease Genetics Consortium. (2021). Causal associations between modifiable risk factors and the Alzheimer's phenome. Annals of neurology, 89(1), 54-65. Olmastroni, E et al. (2022). Statin use and risk of dementia or Alzheimer's disease: a systematic review and meta-analysis of observational studies. European Journal of Preventive Cardiology, 29(5), 804-814. Iwagami, M et al. (2021). Blood cholesterol and risk of dementia in more than 1· 8 million people over two decades: a retrospective cohort study. The Lancet Healthy Longevity, 2(8), e498-e506. Tan, Z. S et al. (2003). Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study. Archives of Internal Medicine, 163(9), 1053-1057. Kivipelto, M et al. (2002). Apolipoprotein E ε4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Annals of internal medicine, 137(3), 149-155. Zhou, Z et al. (2020). Low-density lipoprotein cholesterol and Alzheimer's disease: a systematic review and meta-analysis. Frontiers in aging neuroscience, 12, 5. Sáiz-Vazquez, O et al. (2020). Cholesterol and Alzheimer's disease risk: a meta-meta-analysis. Brain sciences, 10(6), 386. Wingo, A. P et al. (2022). LDL cholesterol is associated with higher AD neuropathology burden independent of APOE. Journal of Neurology, Neurosurgery & Psychiatry, 93(9), 930-938. The Nigerian Paradox Study: Hall, K et al. (2006). Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba. Neurology, 66(2), 223-227. Vascular health and Alzheimer's disease: Levit, A et al. (2020). Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease. Geroscience, 42(2), 445-465. The Effect of Lifestyle on Alzheimer's Risk: Dhana, K et al. (2020). Healthy lifestyle and the risk of Alzheimer dementia: Findings from 2 longitudinal studies. Neurology, 95(4), e374-e383. Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. Geneva, Switzerland: World Health Organization; 2019. https://apps.who.int/iris/bitstream/handle/10665/312180/9789241550543-eng.pdf. Accessed December 4, 2019. MIND Diet: Morris, M. C et al. (2015). MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimer's & Dementia, 11(9), 1007-1014. Morris, M. C et al. (2015). MIND diet slows cognitive decline with aging. Alzheimer's & dementia, 11(9), 1015-1022. van den Brink, A. C et al. (2019). The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets are associated with less cognitive decline and a lower risk of Alzheimer's disease—a review. Advances in Nutrition, 10(6), 1040-1065. Kheirouri, S., & Alizadeh, M. (2021). MIND diet and cognitive performance in older adults: a systematic review. Critical Reviews in Food Science and Nutrition, 1-19. Hosking, D. E et al. (2019). MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study. Alzheimer's & Dementia, 15(4), 581-589. Melo van Lent, D et al. (2021). Mind diet adherence and cognitive performance in the Framingham heart study. Journal of Alzheimer's Disease, 82(2), 827-839. Dhana, K et al. (2021). MIND diet, common brain pathologies, and cognition in community-dwelling older adults. Journal of Alzheimer's Disease, 83(2), 683-692. Thomas, A et al. (2022). Association of a MIND Diet with Brain Structure and Dementia in a French Population. The Journal of Prevention of Alzheimer's Disease, 1-10. Arjmand, G et al. (2022). Effect of MIND diet intervention on cognitive performance and brain structure in healthy obese women: a randomized controlled trial. Scientific Reports, 12(1), 1-14. Nutrition and Dementia Prevention: Yassine, H. N et al. (2022). Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group. The Lancet Healthy Longevity, 3(7), e501-e512. Scarmeas, N et al. (2018). Nutrition and prevention of cognitive impairment. The Lancet Neurology, 17(11), 1006-1015. Publications by Lugavere's mentor, Dr. Richard Isaacson: Isaacson, R. S et al. (2019). Individualized clinical management of patients at risk for Alzheimer's dementia. Alzheimer's & Dementia, 15(12), 1588-1602. Amini, Y., Saif, N., Greer, C., Hristov, H., & Isaacson, R. (2020). The role of nutrition in individualized Alzheimer's risk reduction. Current nutrition reports, 9(2), 55-63. Isaacson, R. S. (2019). Advances in early diagnosis and treatment strategies in the management of Alzheimer's disease. Journal of Managed Care Medicine, 22(4), 17-21. Berkowitz, C. L., Mosconi, L., Rahman, A., Scheyer, O., Hristov, H., & Isaacson, R. S. (2018). Clinical application of APOE in Alzheimer's prevention: a precision medicine approach. The journal of prevention of Alzheimer's disease, 5(4), 245-252. BOOK: The Alzheimer's Prevention & Treatment Diet: Using Nutrition to Combat the Effects of Alzheimer's Disease. Isaacson, R. S., & Ochner, C. N. (2016). Square One Publishers, Inc. Podcast episodes mentioned: The Proof with Simon Hill: The carnivore diet, veganism and nutrition misinformation | Dr Alan Flanagan. The Proof with Simon Hill: Debate: Seed Oils And Heart Disease | Tucker Goodrich And Dr Matthew Nagra Our publications relevant to this topic: Sherzai, A., Edland, S. D., Masliah, E., Hansen, L., Pizzo, D. P., Sherzai, A., & Corey-Bloom, J. (2013). Spongiform change in dementia with Lewy bodies and Alzheimer disease. Alzheimer Disease & Associated Disorders, 27(2), 157-161. Whitehair, D. C., Sherzai, A., Emond, J., Raman, R., Aisen, P. S., Petersen, R. C., & Fleisher, A. S. (2010). Influence of apolipoprotein E ɛ4 on rates of cognitive and functional decline in mild cognitive impairment. Alzheimer's & Dementia, 6(5), 412-419. Lazar, E., Sherzai, A., Adeghate, J., & Sherzai, D. (2021). Gut dysbiosis, insulin resistance and Alzheimer's disease: review of a novel approach to neurodegeneration. Frontiers in Bioscience-Scholar, 13(1), 17-29. Sherzai, D., & Sherzai, A. (2019). Preventing Alzheimer's: Our most urgent health care priority. American journal of lifestyle medicine, 13(5), 451-461. Sherzai, A. Z., Sherzai, A. N., & Sherzai, D. (2022). A Systematic Review of Omega-3 Consumption and Neuroprotective Cognitive Outcomes. American Journal of Lifestyle Medicine, 15598276221117102. Sherzai, D., Sherzai, A., & Sherzai, A. (2022). Lifestyle Intervention and Alzheimer Disease. The Journal of Family Practice, 71(1 Suppl Lifestyle), eS83-eS89. Sherzai, D., Sherzai, A., Lui, K., Pan, D., Chiou, D., Bazargan, M., & Shaheen, M. (2016). The association between diabetes and dementia among elderly individuals: a nationwide inpatient sample analysis. Journal of Geriatric Psychiatry and Neurology, 29(3), 120-125. Sherzai, A., Sherzai, D., Pilot, M., & Ovbiagele, B. (2016). Prevalence of the Diagnoses of Alzheimer's Dementia, Non-Alzheimer's Dementia and Vascular Dementia Among Hospitalized Stroke Patients: A National Inpatient Sample Analysis, 1999-2012 (P1. 125). Follow us on social media: Instagram: The Brain Docs @thebraindocs Facebook: The Brain Docs Website: TheBrainDocs.com

american food blood australian brain healthy mind pilot lifestyle influence current safety nutrition journal disease effects proof alzheimer's disease joe rogan prevention combat lent morris omega relevant gut clinical andrews mediterranean archives dementia brink hansen pan melo advances consumption tan diagnose neurology findings internal medicine brain health frontiers plasma petersen cholesterol lui publications efficacy american journal vazquez dispelling ketogenic rahman ketogenic diet prevalence misunderstandings lifestyle medicine zhou annals food science ldl vascular lazar raman berkowitz individualized european journal cognitive decline isaacson causal randomized amini shaheen family practice saif framingham lewy systematic review wingo statin risk reduction scientific reports max lugavere hosking apoe fleisher lewy body dementia pizzo mosconi levit white hair preventive cardiology critical reviews current opinion mind diet dhana ldl cholesterol brain structure lugavere preventing alzheimer alan flanagan geriatric psychiatry scheyer neurovascular dietary approaches hristov accessed december lifestyle intervention neurotherapeutics expert review apolipoprotein e stop hypertension dash

Presymptomatic neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy

Play Episode Listen Later Oct 17, 2022

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.12.511820v1?rss=1 Authors: Tullo, S., Miranda, A. S., del Cid-Pellitero, E., Peng Lim, M., Gallino, D., Attaran, A., Patel, R., Novikov, V., Park, M., Beraldo, F., Luo, W., Shlaifer, I., Durcan, T. M., Bussey, T. J., Saksida, L. M., Fon, E. A., Prado, V. F., Prado, M. A. M., Chakravarty, M. M. Abstract: There is significant evidence suggesting aggregated misfolded alpha-synuclein, a major component of Lewy bodies, propagates in a prion-like manner contributing to disease progression in Parkinson's disease (PD) and other synucleinopathies. Animal models are essential for understanding and developing treatments for these diseases. However, despite modelling human pathology, most endpoints studied in mice do not translate to humans. Furthermore, the progression by which alpha-synuclein misfolding affects human-relevant measures such as brain volume and underlying subtle, high-level cognitive deficits is poorly understood. Here we used a mouse model of synucleinopathy; hemizygous M83 human A53T alpha-synuclein transgenic mice inoculated with recombinant human alpha-synuclein preformed fibrils (PFF) injected in the right striatum to initiate alpha-synuclein misfolding and aggregation. We examined alpha-synuclein-induced atrophy at 90 days post-injection using ex vivo magnetic resonance imaging as well as high-level cognition and motor function, as biomarkers of alpha-synuclein toxicity. We observed widespread atrophy in bilateral regions that project to or receive input from the injection site, highlighting a network of regions that are consistent with structural changes observed in humans with PD. Moreover, we detected early deficits in reversal learning with touchscreen testing in PFF-injected mice prior to motor dysfunction, consistent with the pathology observed in cortical-striatal and thalamic loops. We show, using translational approaches in mice, that progression of prion-like spreading of alpha-synuclein causes selective atrophy via connected brain regions leading to high-level cognitive deficits. We propose that precise imaging and cognitive biomarkers can provide a more direct and human-relevant measurement of alpha-synuclein-induced toxicity in pre-clinical testing. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

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Synaptojanin1 regulates lysosomal functions in ventral midbrain neurons

Play Episode Listen Later Oct 14, 2022

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.14.512269v1?rss=1 Authors: Zhu, X., Prakash, S. S., McAuliffe, G., Pan, P.-Y. Abstract: A major pathological hallmark of Parkinsons Disease (PD) is the manifestation of Lewy bodies comprised of alpha-synuclein (a-syn). The accumulation of a-syn enriched protein aggregates is thought to arise from dysfunction in degradation systems within the brain. Recently, missense mutations of SYNJ1 encoding the SAC1 and 5-phosphatase domains have been found in families with hereditary early-onset Parkinsonism. Previous studies showed that Synj1 haploinsufficiency (Synj1+/-) leads to PD-like behavioral and pathological changes in mice, including the accumulation of the autophagy substrate p62 and pathological a-syn proteins in the midbrain (MB) and striatum. In this study, we aim to investigate the neuronal degradation pathway using the Synj1+/- MB culture as a model. Our data suggests that autophagy flux and cumulative autophagosome formation is unaltered at baseline in Synj1+/- MB neurons. However, lysosome number is reduced with a similar decrease in lysosomal proteins, including LAMP1, LAMP2, and LAMP2A. Lysosomes are hyperacidified with enhanced enzymatic activity in Synj1+/- MB neurons. Using a combination of light and electron microscopy, we show that lysosomal changes are primarily associated with a lack of SAC1 activity. Consistently, expressing the SYNJ1 R258Q mutant in N2a cells reduces the lysosome number. Interestingly, the lysosomal defects in Synj1+/- neurons does not impact the clearance of exogenously expressed wild-type a-syn; however, the clearance of a-syn A53T was impaired in the axons of Synj1+/- MB neurons. Taken together, our results suggest axonal vulnerability to lysosomal defects in Synj1 deficient MB neurons. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

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FC Barcelona v Inter Milan (3-3) Match Review: Dembele & Lewy Score 3 while Busquets and Pique Fail

Play Episode Listen Later Oct 13, 2022 18:11

The Barca Breakdown reviewed FC Barcelona's draw in the second leg against Inter Milan at the Camp Nou. Every fan felt this game was do or die and the Camp Nou fans' energy was exuberant! The Blaugrana energy was also pouring out on the pitch as players pushed their physical limits. Dembele and Lewandowki were able to score 3 goals. However it wasn't enough. Barca were their own worst enemy as blunders from Pique, Busquets, and Eric Garcia resulted in 3 goals for the Italian side. The result is another knife in the side of Barca fans. Barca find themselves 3rd in the Champions League group still 3 points behind Inter. Inter must lose both remaining games and Barca must win both... but Barca still will face Bayern Munich at the Camp Nou. Xavi and his men will be faced with another challenge this weekend in the highly anticipated El Clasico against Real Madrid at the Santiago Bernabéu. A win against Real would bolster Barca's hopes of taking the La Liga title. Subscribe to our channel for coverage of everything FC Barcelona - Thank you for your support!

Episode 61: Feeling Disconnected from People living with Dementia

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Play Episode Listen Later Oct 10, 2022 21:55

Family caregivers often share that they have lost their connection with people living with dementia. Some limit their communication with the person living with dementia because of constant arguments. Others feel sad when their efforts go unappreciated. In today's episode, you will learn why the disconnect happens and how to handle it. You will learn a handy tip for side-stepping arguments. Make Dementia Your B*tch podcast has been selected by Feedspot as one of the Top 25 Dementia Podcasts for 2022—check it out: https://blog.feedspot.com/dementia_podcasts/ Free VIRTUAL dementia education and support session calendar: https://dementiacentricsolutionsllc.clickmeeting.com/monthly-dementia-webinars Other resources: New! 5 Ways to help People living with dementia who refuse help: https://dementiacentricsolutions.com/caring-for-someone-living-with-dementia-tired-of-fighting-and-arguing/ Have a question? Want more information about my programs? Email me: dr.rita.jablonski@gmail.com Interested in my book? Get your free preview here: https://read.amazon.com/kp/embed?asin=B09SR2ZMM2&preview=newtab&linkCode=kpe&ref_=cm_sw_r_kb_dp_1984RXHNZ8WBNHR7WSJ2 You can also leave questions here: https://anchor.fm/rita-a-jablonski/message #alzheimers #dementia #caregiving #behaviors #dementiabitch #Lewy body #Parkinsons #vascular #care refusals --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/rita-a-jablonski/message

FC Barcelona v Elche (3-0) Match Review: Lewandowski TWO MORE GOALS! Pedri MOTM, Depay Scores!

50+2 - Der Fussballpodcast mit Nico & Niklas

Play Episode Listen Later Sep 17, 2022 9:26

The Barca Breakdown discussed Matchday 6 against Elche. Elche has surely struggled this season as they've plummeted to 20th on the table. Barca's form this season has proved to be strong, scoring many goals, many of which coming from Lewandowski. Unfortunately for Elche, they received a red card for a poor foul on Lewandowski in the 15th minute leaving them with 10 men. Barca certainly capitalized on this opportunity, in the 34' when Balde crossed the ball into the box and Lewy slid in and scored. It was all downhill for Elche from that point. Depay was also able to box out his defender in the box and received a pass from Balde. Depay quickly turned and smashed the ball into the back of the net. The first half ended and Barca completely dominated possession and control of the game. The second half started with Kessie subbed off for Gavi. Soon after, Gavi pushed forward and crossed the ball back to Lewandowski. A one touch shot placed the ball in the left side of the net. Barca lead 3-0. Big shout out to Frenkie De Jong, Balde, and Lewandowski for a great performance and complete domination of the game. Elche only managed 1 shot on goal with a 22% possession. While this game cannot provide any insight on Barca's progress it keeps them very competitive in La Liga. International break has now begun for Barca. The big question is can they keep their form when they return? When we return in October to play Mallorca, we have a big test in the Champions League against Inter Milan. This is the focus of Barca.

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Das ist der perfekte Roger! CL-Rückblick 22/23, 2. Spieltag

Play Episode Listen Later Sep 15, 2022 53:02

Jetzt kommt er langsam auf dich zu, Haaland trifft in dein Gesicht Siehst die Bayern wie im Film Doch der Lewy trifft heute nicht, Das ist der perfekte Roger Das ist der perfekte Tag Lass dich einfach von ihm tragen Denk am besten gar nicht nach. Wirklich, wer das bis hier gelesen hat, ist selbst Schuld. Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte: https://linktr.ee/50plus2

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Superstau dank Lewy - Krawall und Remmidemmi

Eine Halbzeit mit

Play Episode Listen Later Sep 15, 2022 53:20

Neben den zwei ersten Dates mit der Ex behandeln die Protagonisten diesmal auch ein extrem schwieriges Thema - es geht um Randale und Ausschreitungen, um die Verantwortung der Vereine und Verbände. Außerdem: Flicks Pläne mit Blick auf die Winter-WM.

Superstau dank Lewy – Krawall und Remmidemmi

Fußball – meinsportpodcast.de

Play Episode Listen Later Sep 15, 2022 53:20

Neben den zwei ersten Dates mit der Ex behandeln die Protagonisten diesmal auch ein extrem schwieriges Thema - es geht um Randale und Ausschreitungen, um die Verantwortung der Vereine und Verbände. Außerdem: Flicks Pläne mit Blick auf die Winter-WM. Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten.

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Bayerns Ausrufezeichen gegen Barca und Lewy

Eishockey – meinsportpodcast.de

Play Episode Listen Later Sep 14, 2022 14:25

Am Tag nach einem erfolgreichen deutschen Champions League Abend mit drei deutschen Siegen und vor allem dem Sieg der Bayern gegen Barca melden sich Malte Asmus und Andreas Wurm mit der Aufarbeitung der Duelle, aber sie hören auch Ilkay Gündogan und Antonio Rüdiger über ihre Treffen mit alten Freunde heute und eine "Drohung" von Pep Guardiola, außerdem sprechen sie über das Dilemman des 1. FC Köln und den Modus der DEL in dieser Saison. Dieser Podcast wurde produziert mit freundlicher Unterstützung und Text- und Ton-Material unseres Partners, dem Sport-Informations-Dienst SID. Der SID ist Content-Lieferant für nahezu alle großen Sender und digitalen Sport-Portale. Über 90 Prozent aller Sportredaktionen in Deutschland setzen auf den SID. Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten.

Bayerns Ausrufezeichen gegen Barca und Lewy

Fußball – meinsportpodcast.de

Play Episode Listen Later Sep 14, 2022 14:25

Am Tag nach einem erfolgreichen deutschen Champions League Abend mit drei deutschen Siegen und vor allem dem Sieg der Bayern gegen Barca melden sich Malte Asmus und Andreas Wurm mit der Aufarbeitung der Duelle, aber sie hören auch Ilkay Gündogan und Antonio Rüdiger über ihre Treffen mit alten Freunde heute und eine "Drohung" von Pep Guardiola, außerdem sprechen sie über das Dilemman des 1. FC Köln und den Modus der DEL in dieser Saison. Dieser Podcast wurde produziert mit freundlicher Unterstützung und Text- und Ton-Material unseres Partners, dem Sport-Informations-Dienst SID. Der SID ist Content-Lieferant für nahezu alle großen Sender und digitalen Sport-Portale. Über 90 Prozent aller Sportredaktionen in Deutschland setzen auf den SID. Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten.

Bayern rain on Lewy's homecoming, elation at Anfield, Boehly's big ideas, more! | Champions League Recap & Analysis (Soccer 9/13)

Fußball – meinsportpodcast.de

Play Episode Listen Later Sep 13, 2022 61:47 Very Popular

There were no goals for Robert Lewandowski on his Allianz Arena return as Barcelona's wasteful first half cost them, while Jurgen Klopp's men secured a last-gasp win at Anfield. Ian Paul Joy, Nigel Reo-Coker and Michael Lahoud react to both of these games and the rest of Tuesday's Champions League action. Plus, Todd Boehly has big plans for Chelsea... and the rest of the Premier League. (01:23) -- Bayern rain on Lewy's homecoming (12:10) -- Inter Milan are up and running (15:45) -- Liverpool beat Ajax at the death (22:10) -- Big opportunity for Napoli at Ibrox (25:55) -- Sporting deflate Tottenham, Conte's UCL record (33:44) -- Marseille's UCL misery continues (37:23) -- Brugge top of Group B, Levekusen beat Atleti (42:42) -- Todd Boehly's bold plans for football & thoughts on Tuchel ‘Qué Golazo' is available on Apple Podcasts, Spotify, Stitcher, Google Podcasts, Castbox and wherever else you listen to podcasts. Follow the Qué Golazo team on Twitter: @quegolazopod, @JOYPAULIAN, @MikeLahoud, @JimmyConrad, @FabrizioRomano, @Jon_LeGossip, @jamesbenge, Nigel Reo-Coker, @heathpearce, @PartidoPooper Watch Qué Golazo on YouTube: https://www.youtube.com/QueGolazo For more soccer coverage from CBS Sports, visit https://www.cbssports.com/soccer/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ Get 20% off Que Golazo merch, using the code GOLAZO20: https://store.cbssports.com/collections/que-golazo?utm_source=podcast-apple-com&utm_medium=web&utm_campaign=buy-our-merch&utm_content=que-golazo Watch UEFA Champions League, UEFA Europa League, UEFA Europa Conference League, Serie A, Coppa Italia, CONCACAF, NWSL, Scottish Premiership, the Brasileiro, Argentine Primera División by subscribing Paramount Plus: https://www.paramountplus.com/home/ To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Greek Freak und Lewy stoppen

Play Episode Listen Later Sep 13, 2022 14:45

Was Alexander Zverevs Davis-Cup-Absage sportlich und für die Veranstaltung bedeutet, ob Carlos Alcaraz eine neue Ära im Herrentennis begründen kann, wie man den Greek Freak heute im EM-Viertelfinale stoppen kann und wie die Bayern ihre Aufgabe Barca angehen werden, erfahrt ihr von Malte Asmus und Andreas Wurm, Julian Nagelsmann, Dennis Schröder und den Experten vom Chip&Charge-Podcast. Und den mehrfach aktualisierten Newsblock bekommt ihr auch. Dieser Podcast wurde produziert mit freundlicher Unterstützung und Text- und Ton-Material unseres Partners, dem Sport-Informations-Dienst SID. Der SID ist Content-Lieferant für nahezu alle großen Sender und digitalen Sport-Portale. Über 90 Prozent aller Sportredaktionen in Deutschland setzen auf den SID. Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten.

UEFA Champions League preview: Lewandowski v Bayern Munich, Haaland v Dortmund, pressure on Liverpool, Chelsea, Juventus, more! (Soccer 9/12)

Play Episode Listen Later Sep 12, 2022 58:49 Very Popular

All eyes will be on Robert Lewandowski and Erling Haaland on matchday 2 of the UEFA Champions League campaign with both strikers squaring off against their former clubs. Ian Paul Joy, James Benge, Nigel Reo-Coker and Michael Lahoud preview Bayern Munich vs. Barcelona and Manchester City vs. Dortmund as well as the rest of the week's must-watch UCL games on the latest Que Golazo. (01:35) -- Barça & Lewy v Bayern (12:30) -- Man City & Haaland v Dortmund (19:12) -- Liverpool in need v Ajax (30:50) -- Rangers v Napoli, rescheduled games (34:58) -- Potter's Chelsea debut (43:20) -- Milan v Dinamo (44:45) -- Real Madrid v Leipzig (53:25) -- Final thoughts ‘Qué Golazo' is available on Apple Podcasts, Spotify, Stitcher, Google Podcasts, Castbox and wherever else you listen to podcasts. Follow the Qué Golazo team on Twitter: @quegolazopod, @JOYPAULIAN, @MikeLahoud, @JimmyConrad, @FabrizioRomano, @Jon_LeGossip, @jamesbenge, Nigel Reo-Coker, @heathpearce, @PartidoPooper Watch Qué Golazo on YouTube: https://www.youtube.com/QueGolazo For more soccer coverage from CBS Sports, visit https://www.cbssports.com/soccer/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ Get 20% off Que Golazo merch, using the code GOLAZO20: https://store.cbssports.com/collections/que-golazo?utm_source=podcast-apple-com&utm_medium=web&utm_campaign=buy-our-merch&utm_content=que-golazo Watch UEFA Champions League, UEFA Europa League, UEFA Europa Conference League, Serie A, Coppa Italia, CONCACAF, NWSL, Scottish Premiership, the Brasileiro, Argentine Primera División by subscribing Paramount Plus: https://www.paramountplus.com/home/ To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Cadiz v. FC Barcelona (0-4): Frenkie CRUSHES Cadiz's 2 Year Unbeaten Streak Against Barca

Play Episode Listen Later Sep 10, 2022 20:48

The Barca Breakdown discussed matchday 5 away in Cadiz. A team that is 20th on the table with ZERO points and ZERO goals on the charts. Seeing Barca have their first huge match of the season against Bayern on Tuesday, Xavi chose a lineup that featured less starters. Bellerin started as right back alongside Araujo, Pique, and Balde while the midfield started with Frenkie, giving Pedri a rest. Memphis and Torres were the attacking front with Raphinha. As the lineup is very fresh, it was expected to have a slower start. Most goal scoring attempts came from the left side of the field, however, the finishing touches were sloppy and off the mark. Torres continued to sky the ball into the stands and Depay continued to shoot low and weak at the goalie, making for easy saves. A great output was seen from Frenkie and Gavi while Busquets held the midfield ground. However no goals were scored and Cadiz was able to play a heavy defensive line to crowd the box. The second half started with no substitutes. But it was the starting XI that could score the game opener. Raphinha runs up the right side of the pitch getting the ball to Gavi who crosses the ball and the goalie blocks it. The rebound fell to Frenkie de Jong who put in the opening goal. After this moment, the game opens up as Cadiz must score to equalize or lose the game. Xavi then puts on Dembele, Fati, and Lewandowski. Not long after, Bellerin makes a run down the right pitch and gets the ball to Raphinha who crosses the ball into Frenkie and a Cadiz defender. The ball slips off and Lewandowki slides in for the goal! In the 80' the game was paused due to a person in the crowd falling ill. After about a 45 minute delay the game resumed. Fati was able to score in the box from an assist from Lewy and another goal from Dembele! The game ends 0-4 and Barca take another 3 points. The Breakdown looks forward to the midweek Bayern game. Where Barca will face their first huge test of the season.

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Liverpool humbled in Naples, Ajax rinse Rangers, Bayern & Barça cruise, more! | Champions League Recap & Analysis (Soccer 9/7)

Reif ist live - Fußball-Podcast von BILD

Play Episode Listen Later Sep 7, 2022 47:33 Very Popular

Luis Miguel Echegaray, Jonathan Johnson and Michael Lahoud pick over Wednesday's UEFA Champions League action beginning with Group A where Napoli made light work of Jurgen Klopp's disjointed Reds, and Ajax showed they are still a force on the European stage. Plus, Robert Lewandowski put on another show at Camp Nou, Bayern Munich won on the road, Richarlison broke his Tottenham duck, and there was injury time madness at the Metropolitano Stadium. (02:15) -- Napoli ask questions of Liverpool / Klopp's seventh season struggles (13:19) -- Rangers overrun in Amsterdam (19:02) -- Inter outplayed by Bayern / Is Inzaghi in trouble? (23:50) -- Lewy hat-trick / Who forgot about Ferran Torres? (28:55) -- Tottenham huff and puff vs. Marseille (35:15) -- Sporting expose Frankfurt frailties (36:10) -- Griezmann at the death... will Simeone use him more? ‘Qué Golazo' is available on Apple Podcasts, Spotify, Stitcher, Google Podcasts, Castbox and wherever else you listen to podcasts. Follow the Qué Golazo team on Twitter: @quegolazopod, @JOYPAULIAN, @MikeLahoud, @JimmyConrad, @FabrizioRomano, @Jon_LeGossip, @jamesbenge, Nigel Reo-Coker, @heathpearce, @PartidoPooper Watch Qué Golazo on YouTube: https://www.youtube.com/QueGolazo For more soccer coverage from CBS Sports, visit https://www.cbssports.com/soccer/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ Get 20% off Que Golazo merch, using the code GOLAZO20: https://store.cbssports.com/collections/que-golazo?utm_source=podcast-apple-com&utm_medium=web&utm_campaign=buy-our-merch&utm_content=que-golazo Watch UEFA Champions League, UEFA Europa League, UEFA Europa Conference League, Serie A, Coppa Italia, CONCACAF, NWSL, Scottish Premiership, the Brasileiro, Argentine Primera División by subscribing Paramount Plus: https://www.paramountplus.com/home/ To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Transferfinale, Lewy-Show und die „Arschlochfrage“

Play Episode Listen Later Aug 29, 2022 50:50

Robert Lewandowski hat die nächste Show beim FC Barcelona abgeliefert. Außerdem geht die Transferperiode in die finale Phase. Und Bayern-Trainer Julian Nagelsmann hat gegen Gladbach die gelbe Karte kassiert - und dafür eine viel diskutierte Erklärung geliefert. Darüber diskutieren BILD-Sportchef Matthias Brügelmann und TV-Experte Marcel Reif. Außerdem Thema: die Premier League mit dem Haaland-Hattrick und Liverpools 9:0-Erfolg.

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FC Barcelona v Valladolid (4-0) Match Review: Lewandowski &Dembele Shine and Kounde's First Start!

Reif ist live - Fußball-Podcast von BILD

Play Episode Listen Later Aug 28, 2022 17:34

The Barca Breakdown discussed the 4-0 victory against Valladolid. After much anticipation, Xavi started Kounde as the right back alongside Araujo, Garcia, and Balde. Again, Frenkie De Jong lost the starting position to Gavi. And the seemingly standard starting front line of Rahpinha, Dembele, and Lewandowski kicked off at the Camp Nou. The possession was dominated by Barca in the whole 90'. This isn't particularly surprising as Valladolid had recently just returned from regulation and in previous seasons always fell to the bottom of the table. Barca attacked time and time again until Lewandowksi scored from a cross from Raphinha. This opened the game up as players were able to find the open pitch and make runs through the midfield. The wingers dropped to the middle which pulled defenders back allowing Gavi and Pedri to run up the pitch into the box. Many times Gavi was able to get the ball in the box, but held on too long or was covered too quickly. Then the play dies. Moving forward though Dembele lit up the match with two assists. The first was a pass to Pedri at the middle of the penalty box and the second came to Lewy in which he back healed it into the net. Lastly, Lewy just misses a hat trick off the crossbar and Roberto smashes it back. Barca geet another 3 points. However, Valladolid performed very poorly, and this game cannot be completely representative of Barca in its peak performance. Barca just drew Bayern and Inter Milan in the Champions League and these games will be much more of a test of Barca's capabilities.

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Lewy-Tor-Show, Super-Bayern, BVB-Drama & Bundesliga-Fehlstarter

Play Episode Listen Later Aug 22, 2022 49:22

Eine neue Folge „Reif ist Live“ ist da! TV-Experte Marcel Reif analysiert den Doppelpack von Robert Lewandowski beim FC Barcelona, singt ein Loblied auf die Machtdemonstration des FC Bayern in Bochum und sieht dramatische Züge beim BVB. Zudem blickt er auf die Fehlstarter aus Leverkusen und Leipzig, sowie den Spieltag der Premier League.

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Fati and Lewy put on a Barcelona show

Barça Blaugranes: for FC Barcelona fans

Play Episode Listen Later Aug 22, 2022 12:12

Today on the Barca Blaugranes podcast, I chat about the exhilarating Barcelona performance from the weekend. Xavi's men put on a second half spectacle that saw Ansu Fati and Robert Lewandowski shine in an impressive 4-1 away win at Real Sociedad. Is this the start of something special? (I said Bernardo Silva instead of David Silva at the beginning, what can I say? I've got Silva's on the mind.) You can check out the podcast on Apple Podcasts, Spotify, Google Podcasts, and more here. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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The Gary Null Show - 08.19.22

The Gary Null Show

Play Episode Listen Later Aug 19, 2022 64:17 Very Popular

VIDEOS: Dr. Ryan Cole: Covid Vaccine Side Effects Are Like A Nuclear Bomb (10:00) We don't need the CIA – The Chris Hedges Report (10:00) GlyNAC supplementation reverses aging hallmarks in aging humans Baylor College of Medicine, August 19, 2022 A randomized, double blind human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC—a combination of glycine and N-acetylcysteine—improves many age-associated defects in older humans and powerfully promotes healthy aging. This is relevant because until now, there have been no solutions toward improving many of these age-related declines in people. Published in The Journals of Gerontology: Series A, the study shows that older humans taking GlyNAC for 16-weeks improved many characteristic defects of aging. This includes oxidative stress, glutathione deficiency and multiple aging hallmarks affecting mitochondrial dysfunction, mitophagy, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue and cellular senescence. These were associated with improvements in muscle strength, gait speed, exercise capacity, waist circumference and blood pressure. The improvements in oxidative stress, glutathione levels and mitochondrial function in the muscle tissue of older humans taking GlyNAC were similar to the improvements in organs such as the heart, liver and kidneys of aged mice supplemented with GlyNAC as reported in the researchers' recent publication. Taken together, the results of these studies show that GlyNAC supplementation can improve these defects in many different organs of the body. “GlyNAC supplementation in aging mice increased their length of life mice by 24%,” said Sekhar. “Gait speed is reported to be associated with survival in older humans. Our randomized clinical trial found a significant improvement in gait speed in older humans supplemented with GlyNAC. This raises the interesting question of whether GlyNAC supplementation could have implications for survival in people.” Mitochondria generate energy needed for supporting cellular functions. However, the ability of mitochondria to work well declines as we age. How to improve the ability of these failing mitochondria to work is not well understood, and therefore no solutions have been available. Sekhar's group discovered earlier that supplementing GlyNAC in aged mice corrected malfunctioning mitochondria. However, to definitively determine whether GlyNAC supplementation benefited people, a placebo-controlled randomized clinical trial was required. After 16-weeks of GlyNAC supplementation, mitochondrial function of older people improve toward levels found in young people. This was accompanied by improvements in multiple additional outcomes as reported in the publication. Analysis of the molecular data from the trial suggests that the GlyNAC supplementation is able to fill cells with younger and more efficient mitochondria. “Collectively these exciting new discoveries hold great promise for improving our mitochondrial and general health as we age,” Sekhar said. A second vital benefit offered by supplementing GlyNAC is that it also helps protect the body from an important problem called oxidative stress. GlyNAC supplementation corrects glutathione deficiency and lowers oxidative stress in older humans back to youthful levels, thereby solving both problems. “One of the intriguing questions from this trial is why so many improvements occur toward promoting health. We believe that this is due to the combined effort of three separate components—glycine, cysteine (from NAC) and glutathione, and not just due to glutathione itself. Glycine and cysteine are both very important for cellular health on their own, and GlyNAC provides both. Glycine and cysteine are building blocks to form glutathione, which also has health benefits. We believe that the improvements in this trial and in our previous studies are the result of the combined effects of glycine and NAC and glutathione, and we refer to this combination as the ‘Power of 3,'” said Sekhar. GlyNAC supplementation improved muscle strength in the upper and lower extremity and a trend toward increased exercise capacity. “These findings could have additional implications for improving the health of older humans, especially in terms of being able to be more physically active,” said Sekhar. High-fructose corn syrup consumption in adolescence impairs learning and memory University of Southern California, August 12, 2022 Because most corn in America is genetically modified to kill corn “pests,” no human on Earth should be eating it, especially every day. This is now being proven by scientists who run tests on animals in laboratories and have concluded that high-fructose corn syrup (HFCS) and sucrose can impair an adolescent animal's ability to learn, and it can impair its ability to remember information. And that brings us to the rat genome. Research reveals a difference between adult animals that consume HFCS-sweetened beverages and adolescent animals that consume the same. The amounts of HFCS used in the research were very similar to the amounts of GMO sugar found in common soft drinks. The study was conducted over one month. The lead author of the study said it's no secret that soft drinks can lead to not only metabolic disturbances but interference with the brain's ability to function normally and remember “critical information” about one's environment. Dr. Scott Kanoski from the University of Southern California explained, “The hippocampus is such a critical brain region for memory function. In many ways this region is a canary in the coal mine, as it is particularly sensitive to insult by various environmental factors, including eating foods that are high in saturated fat and processed sugar.” Music More Effective Than Drugs At Releasing Brain's Painkillers McGill University (Montreal), August 11, 2022 400 published scientific papers have proven the old adage that “music is medicine.” Neurochemical benefits of music can improve the body's immune system, reduce anxiety levels and help regulate mood in ways that drugs have difficulty competing. “We've found compelling evidence that musical interventions can play a health care role in settings ranging from operating rooms to family clinics,” says Prof. Levitin of McGill University's Psychology Department. “But even more importantly, we were able to document the neurochemical mechanisms by which music has an effect in four domains: management of mood, stress, immunity and as an aid to social bonding.” Like other pleasurable experiences, there are two components to enjoying music: anticipation of hearing your favourite song, and then actually hearing it. The brain signalling chemical dopamine, which is linked to reward, is involved in both phases. But neuroscientists have wondered for decades whether there was more to it — what gives music its power to induce euphoria? The brain's natural opioids could be key. Professor Levitin's team showed that blocking opioid signals in the brain by giving people a drug called naltrexone reduces the amount of pleasure they report getting from their favourite song. They still enjoy the anticipation of hearing the song just as much, suggesting that, although dopamine is involved, it's when the opioids kick in that music really starts to affect our minds. A flood of opioids would also explain music's effect on our body. Listening to music is known to raise people's pain thresholds, so much so that in some cases, it can be used to reduce the need for morphine-like painkillers. In their analysis, Levitin's team surveyed over 400 papers, looking for patterns in the scientific evidence supporting the claim that music can affect brain chemistry in a positive way. They succeeded in isolating four areas where music can help: Reward, motivation, and pleasure (to help with eating disorders, as an example) Stress and arousal (to help reduce anxiety) Immunity (to strengthen the body's immune system and slow-down age related decline) Social affiliation (to assist in trust building and social bonding) The researchers connected these areas with four primary neuro-chemical systems: Dopamine and opioids Cortisol (and related hormones) Serotonin (and related hormones) Oxytocin “We know music facilitates active neurochemical processes in a symphony of opioids which pharmaceutical intervention has been unable to match,” said Dr. Francis Chandra commenting on the study. Calcium & magnesium reduce risk of metabolic syndrome: 9000-strong study Case Western Reserve University, August 14, 2022 Calcium and magnesium may reduce the risk of metabolic syndrome – but men need above and beyond recommended levels for this effect, say researchers. The researchers from the Case Western Reserve University in the US used 9,148 adults to test the theory that higher dietary intakes of calcium and magnesium decreased the risk of metabolic syndrome. Using 24-hour recalls as part of the National Health and Nutrition Examination Study, they found women who met the US recommended dietary allowance (RDA) for both magnesium (310–320 mg per day) and calcium (1000–1200 mg per day) saw the greatest decrease in risk of metabolic syndrome. The European RDA for magnesium is 375 mg and 800 mg for calcium. Meanwhile, they did not see the same association for men meeting the RDA for magnesium (400–420 mg per day) and calcium (1000–1200 mg per day), individually or in combination. However, when these intakes were increased to over 386 mg for magnesium and over 1224 mg per day for calcium, the odds of metabolic syndrome for the men was lowered. “The underlying mechanisms driving the differences we and others have observed by sex are not well understood and warrant additional mechanistic studies,” the researchers wrote. The study measured serum triglyceride, high-density lipoprotein (HDL) cholesterol and glucose levels as markers of the condition Treadmill exercise shown to improve Parkinson's symptoms in mice Rush University Medical Center, August 18, 2022 Regular treadmill exercise helped improve Parkinson's disease symptoms in mice in a recent study by researchers at RUSH University Medical Center. The results of the study were recently published in the Cell Reports. “We're very excited about the results,” said Kalipada Pahan, Ph.D., Floyd A. Davis, MD, Endowed Chair in Neurology and professor of neurological sciences, biochemistry, pharmacology at the RUSH University Medical Center. “Our hope is that we can use this as a jumping off point for furthering our ability to help Parkinson's patients manage their symptoms.” In the study, scientists found positive results in using regular treadmill exercise to stop the spread of the α-synuclein protein and reverse biochemical, cellular, and anatomical changes that occur in the brains of mice with Parkinson's disease in the absence of any drugs. The mice in the trial ran on a treadmill consistently in 30-minute intervals for six days a week, over the course of two months. The findings are key in the ongoing research of Parkinson's, but Pahan and his team were quick to note that while treadmill exercise is something that can be easily available and accessible, some patients with Parkinson's might not be able to run on a treadmill daily. “Once patients are diagnosed with these neurodegenerative disorders, there are no drugs available for halting the disease progression,” Pahan said. “Understanding how the treadmill helps the brain is important to developing treadmill-associated drugs that can inhibit α-synuclein pathology, protect the brain, and stop the progression of Lewy body diseases.” 30 Minutes of Reading a Day Could Add Years to Your Life University of Sussex (UK) and Yale University, August 7, 2022 Past studies have shown that reading books can benefit people in a multitude of ways, physically, mentally, and intellectually. Now in a new study, people who read a book for about 30 minutes a day were found to live approximately 2 years longer than those who didn't read at all. In previous research, curling up with a good book has been shown to improve people's social skills by improving their ability to read the thoughts and feelings of others. Researchers at the University of Sussex in England found that reading was “the most effective way to overcome stress” – even better than listening to music, having a cup of tea, or going for a walk. Reading has also been proven to be a great way to keep the mind sharp, and may reduce mental decline by 32%, helping to prevent Alzheimer's disease. For the new study, researchers from Yale University analyzed data on 3,635 people age 50 and older. The participants were divided into 3 groups – those who didn't read at all, those who read up to 30 minutes a day, and those who read for longer than 3.5 hours per week. Those who read the most tended to be women with college educations and high incomes. The researchers said that book readers appear to have a “significant survival advantage” over people who don't read books. The study didn't address whether reading on a Kindle or other tablet device counted, but it did find that book readers in general lived an average of 2 years longer than non-readers. Specifically, the researchers found that people who read up to 3.5 hours a week were 17% less likely to die over the study's 12-year follow-up period than participants who read no books. This was after accounting for the participants' age, race, self-reported health, depression, employment, and marital status. Compared with those who didn't read books, those who read for more than 3.5 hours a week were 23% less likely to die overall.

James Galvin, University of Miami – Properly Diagnosing Lewy Body Dementia

The Academic Minute

Play Episode Listen Later Aug 17, 2022 2:30

On University of Miami Miller School of Medicine Week: Misdiagnosis is a common problem that can cause havoc for patients. James Galvin, professor of neurology, delves into how to stop this for one disease. James Galvin, M.D., M.P.H., has over 25 years as a clinician-scientist specializing in brain health, cognitive aging, Alzheimer's disease, Lewy body […]

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Euro-Eintracht gegen Real, aber ohne Kostic! So kämpft de Ligt um seinen Abwehrboss-Platz! Lewy droht Tribünen-Start

Reif ist live - Fußball-Podcast von BILD

Play Episode Listen Later Aug 10, 2022 15:44

Hier läuft heute eine Folge von Stammplatz, dem täglichen Fußball-Podcast von BILD. In dieser Episode sprechen die Hosts André Albers und Kilian Gaffrey über den europäischen Supercup heute Abend, den Kostic-Abgang und vieles mehr.

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Bavarian Podcast Works S5E6: Thoughts on Bayern's thumping victory at Frankfurt; talking Bayern post-Lewy; analyzing the 4-triple-2 formation; and more!

Bavarian Football Works: For Bayern Munich fans

Play Episode Listen Later Aug 8, 2022 56:50

Bayern Munich looks very different from the side we have been used to seeing, and in a good way. Of course, the 6-1 thumping of Frankfurt on Friday was only the first game of the season, but it showed a lot of promise for the rest of the season and gave us a glimpse of Nagelsmann's strategies for this side, and the plans he wishes to implement moving forward. The 4-2-2-2 is just one of many formations Nagelsmann can deploy this season, but it certainly seems to be one that he favors. He also has the right personnel to execute it to perfection, so we might be seeing a lot more of the same in upcoming fixtures. With the squad super stacked everywhere and spirits looking high, one can't help but speculate whether this is going to be another one of those historic seasons (in a good way, of course). But yeah, too soon to say anything. All that being said, Tom and Schnitzel sit down in this edition of the flagship show to discuss many positives (positivity is good :)) and some minor concerns, while also postulating to guess how the rest of the season could pan out. Here are the major talking points discussed in this episode: Bayern's dominant performance against Frankfurt How Chuck steals the spotlight all the time, leaving the rest of us poor folks hanging The 4-triple-2 and what it brings to the table Nagelsmann's plans for the rest of the season Tom's insufferable EPL talk and Schnitzel trying hard to bring him back on track Sané transfer rumours Throwing shade at INNN and Teddy (once again) A look at the other fixtures in the BuLi and early predictions for the rest of the season Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Bavarian Podcast Works S5E3: How Robert Lewandowski leaving affects Bayern Munich (Transfers, tactics, and expectations)

Bavarian Football Works: For Bayern Munich fans

Play Episode Listen Later Jul 18, 2022 67:28

So it happened. Bayern Munich have sold Robert Lewandowski to FC Barcelona for a fee of around €45m guaranteed plus €5m in bonuses. With his departure, Bayern lose a striker who has scored 50+ goals a season for three seasons in a row. Without him, Julian Nagelsmann will have to find new solutions for the attack, while the transfer fee raises money to reinvest into the squad. Since this is a major discussion, we got three people together for only our second-ever three-person podcast. In this episode, INNN, Tom, and Schnitzel discuss: Our initial impressions on Lewandowski leaving the club. Can the striker pairing of Sadio Mane and Serge Gnabry make up for the loss of Lewy's goals? The problems with the rumored 3-5-2 formation planned by Julian Nagelsmann. Schnitzel suggests a different formation that gives INNN conniptions. How Bayern can still operate a 4-2-3-1 with Sadio Mane as a lone striker. INNN's take: Why the defense needs to be the focus for the upcoming season. Massive argument about formation fluidity and how to use Thomas Muller. What transfers do Bayern Munich have left in the window? Which transfers are still likely? Why Cristiano Ronaldo could still end up coming to Bayern. Closing thoughts — what are the expectations for Julian Nagelsmann in the upcoming season? Expected positions in the Bundesliga, DFB Pokal, and the Champions League. If you guys like what you hear, PLEASE vote for us on the World Soccer Talk — Best Club Podcast award. Go on that page and vote for Bavarian Football Works. We cannot lose to a Spurs pod! Be sure to stay tuned to Bavarian Podcast Works for all of your up to date coverage on Bayern Munich and Germany. Follow us on Twitter @BavarianFBWorks, @jeffersonfenner, @TheBarrelBlog, @tommyadams71, @bfwinnn, and more. Learn more about your ad choices. Visit podcastchoices.com/adchoices

JOKE SILVA: The Standard of the Woman To Marry ~ Olu Jacobs. (5 Tips)

EMPIRE LIFESTYLE

Play Episode Listen Later Jul 14, 2022 10:52

Wow... isn't she lovely... Ms. Joke Silva. A.k.A Mrs. Joke Olu-Jacobs, the wife of a veteran Nigerian actor who starred in several British television series and international films... --> READ THE BLOG POST HERE https://lolaandola.com/joke-silva-the-standard-of-the-woman-to-marry-olu-jacobs-5-tips/ --> WATCH VIDEO VERSION HERE https://youtu.be/ZeHfFrKqFm8 And whose 80th birthday was celebrated by friends and lovers around the world from Lagos Nigeria on Sunday, July 10th, 2023. If you are looking for a wife or looking to maintain a blissful marriage long term with your wife, I have extracted 5 simple but massive tips for you to apply to your own life. The first tip is to marry a woman whose name is Joke. Okay... That was a joke... no pun intended. My beautiful wife's middle name is also Joke. But the chances of you finding a Joke is slimmed to almost none. I do have another 5 tips for you. And I QUOTE... "‘Wow! This is the standard of the woman I'm going to marry." That was what Olu Jacobs told his wife of some 37+ years when he first laid eyes on this beautiful young woman who was in her early 20's at the time. Listen. We don't know them personally... but never mind all that... This is “couple goals”. At least, we can see a real life example of what marriage was designed to do even in the entertainment industry which is notorious for random divorces. Did you see my last video on Funke Akindele and JJC Akindele… Gentlemen… we have to step our game up. These women belong to you if you can get your sh*t together. Don't you get tired of the horrible divorce, paternity fraud, and etc stories? Anyway, if you are struggling in dating, relationships, marriage, parenting, career etc... Consider sending me a text message with the word "HELP" to +1 (732) 517-7532 and I will see what I can do. Let's countdown the 5 tips from Mr Olu Jacobs and Ms Joke Silva. Tip #5 - Avoid attachments to ideology A lot of young men these days, in response to the decline to the pride that comes with the nuclear family, are now subscribing to archaic ideologies as a quick solution. In fact, it's a major talking point that one of the signs of unruly women is when they choose to keep their maiden name as opposed to changing to their husband's family name as the new last or surname. While I recognize the pride attached to the culture of women changing names once they get married, there is something to say to a man who is secure in himself enough to say these words and managed to keep his home together for 37+ years. And I'm quote... “She is her individual. When I met her, she was an actress known as Joke Silva, so why should marrying me deny her audience her name. She is Miss Joke Silva, who is Mrs Joke Jacobs. It is as simple as that. People now begin to say all sorts. They have even written that we are separated and all sorts of stuff. When she is working, she is Joke Silva, but she is Mrs Joke Jacobs at home,” That was Olu Jacobs speaking to rumors in the past. Tabloids used to be entertainment for women. But sadly in this modern era, men would join and shame this man who actually is an example of their secret desired results. They shame him because he chose not to have an unhealthy attachment to the ideology of his wife changing her brand name after getting married as far back as 37+ years ago in the still "traditional non-westernized" Nigeria. You've sworn you know everything about the traditional Africans right? Sure you should stand for something so you don't fall just for anything. But as a man, you must know how to identify and create valid exceptions in life. If you don't, you will suffer from your own ignorance. Tip #4 - Make finances the least of your problems when it comes to marriage In a few Instagram posts on July 10th, 2023, you can see Ms. Joke Silva fitting her husband, visually appearing to be in his old age but also sick with a condition called Dementia with Lewy bodies. Dementia with Lewy bodies (DLB) is a type of progressive dementia that leads to a decline in thinking, reasoning and independent function. Many young man today are stupidly concerned about how much weight a lady gains after having the first baby when that's fundamentally an attraction issue that should have been ironed out earlier. Others worried about superficial nonsense like if she makes more money or not... fundamentally an insecurity issue on the part of the man. In reality, these are the least of your issues when you are doing life with a person you love and are in-love with. Inevitably, crises will fall on you and whoever you are spending time with in life. If you are an immature person, the easiest thing for you to do is to blame it on the closest person or things like finances, infidelity, in-laws.... but the reality is that there are deeper issues… And Ultimately… you do not know tomorrow… but yet acting like God. Focus on finding a wife... a good thing... someone you can see yourself with when you are sick and 90 years olds... flat boobs, wrinkle... and all.... provided you feel a physical attraction to them today. Anxiety about tomorrow and yesterday will destroy and rob you of your chances of achieving true joy. Clearly... Olu Jacobs is reaping what he sowed over the last 37 years and most likely beyond. Tip #3 - Leverage your work and reputation to do the bragging for you. When Aunty Joke first met Uncle Olu at a rehearsal around 1981, she had heard a lot of good things about him... “a man coming from England to play the lead role.” The anticipation and excitement about a person she had never met... she looked forward to meeting him. In this time and age, there are many men of all ages sadly roaming around social media creating reputations of polar opposite. Many ladies are pinged into online and social media spaces to hear how some men have chosen to address women in disrespectful, generalized and rude manners. That's also a form of reputation right? Well, Law 5 of the 48 laws of power by Robert Greene says "So Much Depends on Reputation — Guard It with Your Life." Question of the day: Do you think Mr Olu Jacobs' reputation that worked ahead of him made it easier for him to woo a fine lady like Ms Joke Silva or it didn't matter what type of reputation it was? Answer me in the comment area below. Tip #2 - Forgive yourself and move forward. When they first met, here was his first statement and I quote... "Wow! This is the standard of the woman I'm going to marry." Ms Joke Silva thought it was a rubbish pick up line. But she said, he continued to demonstrate being a "wonderful" person during the rehearsals. She thought he realized... and I quote... "He had made a faux pas and tried to get in my good graces after that. And we became excellent friends." I would argue that he confidently forgave himself as fast as humanly possible if at all necessary and moved on to demonstrate self-respect, self-validation, high self-esteem which in turn made her feel safe and secure around him. Does a typical woman feel safe and secure around you after running your mouth online? I am not talking about the women advocating for men's rights online. Are you attracting the S.I.G.N language from the typical woman and having a hard time holding yourself accountable? Shame, Insults, Guilt, Need to be right… Nagging. Or maybe… you are the first to beat the ladies to the S.I.G.N language… “these 304s ain't sh*t!” What I observe these days are a bunch of young men who need external validation in order to remain in their masculine frame; an oxy-freaking-moron. They need the modern woman to be checked and roasted constantly; needy behavior. Tip #1 - Leverage her feminine energy The feminine energy is there ready to receive, multiply and reciprocate back to you. It's like the ocean with a massive chaotic-like trend. If you attempt to swim against it, you will drown yourself. That's a whole series of processes, it takes time and that whole phenomenon and the respect that comes with it will be earned; no exceptions. Yes! The beautiful feminine energy is conditional. The conditions and passing the non-intentional and endless shit tests from women overall is what makes you a man. If you have problems with this reality, you will attempt to "fake-masculine" and demand respect and you will fall flat on your face all bruised up 100% of the time. Feel free to try and prove me wrong. In no way, shape or form am I asking you to engage an unruly or disrespectful woman and attempt saving her, you will fail. But I will continue to hold you accountable for engaging unruly or disrespectful community of women and attempting to save them. It's a YOU problem. Stop the cap and Fix YOU!

Fabrizio Romano: Sterling to Chelsea imminent, Barça not giving up on Lewy, Ronaldo will get what he wants | Transfer News & Notes (Soccer 7/8)