POPULARITY
3 episodes with Exosome
5 episodes with Exosome
2 episodes with Exosome
2 episodes with Exosome
2 episodes with Exosome
2 episodes with Exosome
2 episodes with Exosome
In this episode, I dive deep into the transformative world of regenerative medicine with Dr. Ed Park—a leader who has spent nearly two decades pushing the boundaries of aging and healing. Curious about exosomes and how these tiny biological messengers are redefining our ability to recover from injury, illness, and even chronic conditions? You'll love this conversation. What we discuss: Why exosomes? Origins, discovery, and benefits of stem cells ... 00:03:00 How exosomes communicate and trigger healing ... 00:06:00 Exosomes for neurological repair and brain injuries ... 00:10:00 Exosome delivery: IV, targeting, and blood-brain barrier ... 00:12:00 Exosomes in musculoskeletal injuries and healing rates ... 00:18:00 Patient selection, expectations, and placebo effects ... 00:23:00 Exosomes for immune system support and aging ... 00:30:00 Lifestyle pillars alongside regenerative medicine ... 00:32:00 Exosomes in cardiac and nerve repair ... 00:34:00 Provider training, resources, and Dr. Park's practice ... 00:43:00 Closing remarks and medical disclaimer ... 00:45:00 Our Amazing Sponsors: Timeline: Mitopure: is a breakthrough supplement that promotes cellular renewal. It contains Urolithin A, which helps your body clear out damaged mitochondria and create new, efficient ones—giving you more sustainable energy. Timeline is offering 10% off your order of Mitopure now. Go to timeline.com/NAT10. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
80% of diseases are impacted by environment or lifestyle described as your exposome. Thomas Hartung expects information from studying the exposome will bring benefits on par with those brought by studying the human genome.
ハーフマラソン参加を通じたコンディショニングの変化、Bluesky移行など。論文紹介は、valenceに応じた伝達物質放出の変化、生きた細胞からのトランスクリプトミクス、空腹による恐怖表象の変化 (12/15収録) Show Notes (番組HP): UW medのハーフマラソン 村上春樹のエッセイ 腸脛靭帯炎 ボストンマラソンのエントリー基準 Garminのスマートウォッチたち (割と山に特化したfenix 7を使ってます 萩) 萩原(暫定)おすすめデカフ1: Sightglass Coffee 萩原(暫定)おすすめデカフ2:Linea Coffee 宮脇おすすめKarma Coffee V60 手で押すタイプのエスプレッソマシン アーロンチェア Sayl Logitechの575 Mx Ergo S Logitech Lift エレコムのベアリングトラックボールマウス 日本では謎に高い NIH Armamentarium NatureでもBluesky移行の記事が出ていた Nikolas KaralisによるBluesky移行ガイド NeuroRadioのBlueskyアカウント American Football Cap'n Jazz このへんのバンドはより正確には”midwest emo”らしいです Hiatus Kaiyote - Red Room Robert Glasperの生歌が下手すぎるRed Room Robert Glasper Experiment の Smells Like Teen Spirit Robert Glasper Trio - LIVE at The Village Vanguard Darkside Tyler, the Creator Kendrick LamarとSZA トム・ヨークのツアー 観光客に成り下がっている写真 The Smile 論文紹介パート 論文１：Encoding opposing valences through frequency-dependent transmitter switching in single peptidergic neurons Sung Han (気づいたらAssociate Profになってました) Richard Palmiter ポスドクにおける仕事 先に出たリソース論文の仕事 五十嵐さんが最初に出たとき Synapto pHluorine GabaとDopamineが一緒に放出されるケース Central Amygdalaはめちゃくちゃヘテロ Plateau Potential NNに出てた呼吸の論文 論文２：Live-cell transcriptomics with engineered virus-like particles Paul Blainey ピペットでちょっと吸うタイプのlive cell transcriptomics Exosomeを使ったケースについてのレビュー Gil Westmeyerラボから同じ時期に出た類似プレプリント CellNet CROP-seq Evan Macosko Synapse-seq Synaptosomeを分けてシーケンスするのではなくBarseqみたいな感じですね汗 最近出ていたTissueからの経時的intactサンプリング Jerzy Szablowski 論文３：Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum Sabatiniラボ ケータイのラボからのプレプリント GRAB 今回使っているdLight3.8はRoshgadol et al., in preparationとのこと Robert Datta MoSeq Tail of Striatumのaversive stimulus coding Dattaがclosed loopでrewardingなdopamineを叩く この前のSaunders ポスドクのときにいたJanakラボ 似たタスクを作ったのは院生の頃っぽい RealTimeLinux Editorial Notes: ハーフ2時間は切れましたがベンチ100kg上がらなくなりました (萩原) このあと背中攣りました。そしてSteelcaseのThinkを拾いました (脇)
Are exosomes the planet's ultimate healing tool?! In this episode, Dave Asprey sits down with Harvard-trained physician Dr. Edward Park to explore the groundbreaking science of exosomes. Dr. Park, a pioneer in regenerative medicine and author of Exosomes: Songs of Healing, explains how these tiny cellular messengers are revolutionizing health and longevity by bypassing the limitations of stem cells. BUT this episode isn't just about cutting-edge science. Dr. Park also shares profound insights into life, resilience, and emotional well-being, offering advice that goes far beyond medicine. From the power of forgiveness to breaking free of limiting beliefs, his perspective blends science, spirituality, and practical wisdom for living a better life. Here's what you'll learn in this episode: • How exosomes work and why they're being called the future of regenerative medicine • The key differences between exosomes and stem cells—and which is better for healing • Real-life applications of exosome therapy for injuries, anti-aging, and overall health • The potential of exosomes to enhance brain function, reduce inflammation, and promote recovery • Dr. Park's advice on emotional resilience, gratitude, and creating lasting change With over a decade of experience, Dr. Park shares compelling case studies, cutting-edge insights, and practical advice for anyone looking to upgrade their body, mind, and life. Whether you're managing chronic pain, exploring anti-aging therapies, or seeking wisdom for navigating life's challenges, this episode has something for everyone. Sponsors TRU KAVA | Go to https://trukava.com and enter code DAVE15 at checkout for 15% off Resources: • 2025 Biohacking Conference – https://biohackingconference.com/2025 • Dr. Edward Park's Website: Recharge Biomedical – https://www.rechargebiomedical.com • Dr. Edward Park's Book: Exosomes: Songs of Healing – https://www.amazon.com/EXOSOMES-Songs-Healing-Ed-Park/dp/098260632X • Dr. Edward Park's YouTube Channel – https://www.youtube.com/channel/UCpp9DlRArB1rKAWNwoouiTg • Dr. Edward Park on Instagram – https://www.instagram.com/dredpark/ • Dave Asprey's Website – https://daveasprey.com • Dave Asprey's Book: Smarter Not Harder – https://daveasprey.com/books • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey's Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Timestamps: • 00:00 Introduction to Exosomes and Healing • 00:48 Understanding Exosomes: Stem Cell Communication • 01:19 Dr. Edward Park's Insights on Exosomes • 02:47 Exosomes vs. Traditional Treatments • 04:44 Exosomes in Regenerative Medicine • 07:33 Cost-Effective Regeneration Protocols • 12:35 Exosomes for Hair Growth • 14:37 Stem Cells and Brain Health • 25:33 Banking Stem Cells for Future Use • 35:27 Epigenetic Age and Longevity Predictors • 37:48 CRISPR and Gene Editing: Risks and Benefits • 39:43 Basic Health Tips for Longevity • 41:02 Spirituality, Past Lives, and Healing • 42:50 Questioning Medical and Political Narratives • 47:54 The Importance of Free Speech • 01:07:40 The Role of Intuition in Medicine • 01:09:22 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
If you have vision problems, this episode is for you! Visual performance can be improved with physical therapy for your eyes, quality food, top supplements, and biohacking tools such as microcurrent devices for the eyes which are all topics of today's show. Special notes about Starguardt disease at the end. Not listening on Spotify? Find show notes at: https://ashleydeeley.com/w2w/nautraleyecare New episodes of Welcome to Wellness released every Friday. Brought to you by Primeadine Dr. Marc Grossman is a holistic optometrist on a mission to help others improve their vision holistically. 4:15: What are floaters and how to reduce them (blog post on floaters) 6:53: Digestive enzymes can reduce floaters! So can peptides! 10:05: Tom Beckman + Heart Math Institute 11:19: Eyes hurt when reading? Check prescription and check out Irlen syndrome for tinted glasses for relief from eye strain 13:15: How pregnancy affects vision 14:10: Testosterone eye drops for dry eye treatment 17:45: Exosome injections and high dose fish oil as treatment for dry eye 18:41: Microcurrent device for the eyes 20:34: NMN for eye health 20:59: Advice for macular degeneration 21:52: Supplements for eye health: Lutein and Zeaxanthin Mesozeaxanthin Lion's Mane mushroom extract Billberry 25:26: Four minute workout - Zach Bush 25:51: Organic Castor oil (castor oil packs) 26:17: Free eBook for Eye Exercises 30:20: Migraines and eye pressure 34:34: Advice on Starguardt's disease: Studies have indicated Vitamin A and beta carotene should be avoided in food and supplements. They have put together Stargardt packages that avoid these nutrients as well as other carotenoids that can be converted to vitamin A, but contain a wide range of nutrients to support retinal and overall vision health. Stargardt's Package 1 (3-month supply) OR Stargardt's Package 2 (3-month supply) - same as package 1 but with NMN added. Also, take a look at the following home unit - Microcurrent Stimulation 100ile Purchase Option Where to find Dr. Grossman: Website Podcast
In this episode, Dr. Rohrich is joined by dermatologist Dr. Janine Hopkins to discuss advancements in exosome therapy.
Exosome technology is a hot topic in the skincare industry. The skin in the eye area is thinner and delicate, making it more prone to aging. Exosome technology allows for the delivery of proper ingredients to repair and maintain the health of the skin and Lira Clinical has developed a new eye cream that incorporates exosomes and addresses specific concerns around the eyes. Find out more about the PRO Refining Eye Crème and how Exosome Technology is advancing skincare.
Exosome technology is a hot topic in the skincare industry. The skin in the eye area is thinner and delicate, making it more prone to aging. Exosome technology allows for the delivery of proper ingredients to repair and maintain the health of the skin and Lira Clinical has developed a new eye cream that incorporates exosomes and addresses specific concerns around the eyes. Find out more about the PRO Refining Eye Crème and how Exosome Technology is advancing skincare.
Exosomes, Stem Cells, Mitochondria - Join us in this week's podcast where we sit down with Dr. Jordan Plews, a leading expert in biochemical engineering and co-founder of Elevai Skincare! We explore the revolutionary potential of exosomes in regenerative medicine and skincare. Dr. Plews breaks down the science behind exosomes, explaining their origin, function, and the crucial factors that determine their effectiveness in aesthetic treatments. The conversation delves into the nuances of exosome sourcing, the superiority of mesenchymal stem cells from Wharton's Jelly, and the challenges posed by marketing misinformation in the industry. Dr. Plews also shares the latest advancements in exosome-based products, including their role in accelerating post-procedure recovery and supporting long-term skin health. This episode is a must-listen for practitioners and skincare enthusiasts eager to stay ahead in the rapidly evolving field of regenerative aesthetics.
In this episode of The Dr. Geo Podcast, Dr. Geo Espinosa sits down with Dr. Johan Skog, the Chief Scientific Officer and founding scientist of Exosome Diagnostics, to delve into the groundbreaking Exosome DX test. This innovative urine test is designed to determine whether a patient needs a prostate biopsy, providing a non-invasive approach to diagnosing prostate cancer. Dr. Skog explains the fascinating science of exosomes and their crucial role in this diagnostic process.The conversation covers the development and validation of the Exosome DX test, highlighting its sensitivity and predictive values. Listeners will gain insights into the clinical implications of this diagnostic tool and the shared decision-making process between patients and doctors. Dr. Skog also discusses his background and the scientific rigor that underpins the Exosome DX test, emphasizing its potential to minimize unnecessary biopsies and enhance patient care.----------------Thank you to our July Sponsors:The Decipher Test: The Decipher Prostate Test by Veracyte analyzes specific genes in a prostate tumor to assess cancer aggressiveness, aiding in personalized treatment decisions and improving patient outcomes. Learn more about the Decipher Prostate Test here [https://bit.ly/4cNH805].ExoDx: The ExoDx Prostate Score is a non-invasive urine test for assessing the risk of aggressive prostate cancer, using cancer-specific genomic biomarkers. Scores below 15.6 indicate low risk, while scores above 15.6 indicate higher risk. Decisions on further actions, such as biopsies, should involve shared decision-making between the doctor and patient. Learn more about ExoDx here [https://bit.ly/3oA8rXC].XY Wellness: XY Wellness provides a high-value roadmap to health and wellness for men with prostate cancer. Co-founded by our Chief Medical Officer, they aim to help men thrive post-diagnosis. [Learn more about XY Wellness here [https://bit.ly/3uJPC7Z].----------------Thanks for listening to this week's episode. Subscribe to The Dr. Geo YouTube Channel to get more content like this and learn how you can live better with age.You can also listen to this episode and future episodes of the Dr. Geo Podcast by clicking HERE.----------------Follow Dr. Geo on social media. Facebook, Instagram Click here to become a member of Dr. Geo's Health Community.Improve your urological health with Dr. Geo's formulated supplement lines:XY Wellness for Prostate cancer lifestyle and nutrition: Mr. Happy Nutraceutical Supplements for prostate health and male optimal living.You can also check out Dr. Geo's online dispensary for other supplement recommendations Dr. Geo's Supplement Store____________________________________DISCLAIMER: This audio is educational and does not constitute medical advice. This audio's content is my opinion and not that of my employer(s) or any affiliated company.Use of this information is at your own risk. Geovanni Espinosa, N.D., will not assume any liability for...
----- BraveTV Official Website: https://BraveTV.com Store: https://BraveTV.com/store Podcasts: https://BraveTV.com/watch About Dr. Jason Dean: https://BraveTV.com/about ----- BRAND NEW UPDATED Jan 8, 2024 FREE BraveTV Newsletter BraveTVNews.com BLACK November Special!! Work one-on-one with Dr. Jason Dean in his practice. You will get a Full New Patient Consult as well as a Report of Findings and an opportunity to work with Dr. Dean on your customized program for only $99 up front. You can also add a on a special DNA Report for just $297! Sign up HERE! www.workwithdrdean.com/qualify NEW SAVINGS!!! Full Moon Protocol $197 Today with PROMO Code BTV - SAVE over $20 Get your Full Moon Protocol at: https://bravetv.store/ The United States Federal Government has purchased over $200 MILLION in ANTIi-Radiation Medications for a coming Nuclear Event! Grab Your Pre-Sale Special Atomic Detoxified Iodine, a SPECIAL Edgar Cayce Formula! https://bravetv.store/products/pre-sale-bravetv-iodine-formula-will-ship-early-october-1-2-oz-size To change your retirement to Silver IRA's, be sure to check out my Plan for you at http://www.kirkelliottphd.com/DrDean For Vaccinated and Spike Protein Shedding, clean your arteries out with NEW Nattokinase and Vitamin C Power at https://bravetv.store/collections/bravetv-supplements Get CLEAN American Grasslands Beef for your family at http://mylibertybox.com/Drdean
An opportunity to detect pancreatic cancer at stages where early intervention can greatly extend life and even make cure possible seems to be on offer, according to findings from a study of a new liquid biopsy method based on so-called exosomes: subcellular molecules shed into the circulation by cancer cells. At the AACR Annual Meeting 2024 in San Diego, Peter Goodwin talked with Ajay Goel, PhD, AGAF, senior author of the study and Chair of the Molecular Diagnostics and Experimental Therapeutics in the Beckman Research Institute at City of Hope in Los Angeles.
In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with David Weir, MSN, APRN, NP-C, about exosomes and the challenge of limited substantiated science.The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.0:00 Introduction0:55 Guest, David Weir3:00 Exosomes in the aesthetic industry 7:12 Studies with exosomes10:40 Questions of safety and dosage 12:50 Exosome sources 18:10 How genetics play into exosome contents 24:40 Responsibilities of consumers, providers, and companies 28:40 What questions patients should ask about exosome products33:40 Concluding statements
Joined with Jeffrey D. Gross, MD, a spine fellowship trained, board certified neurological surgeon. In his practice, he provides specialized treatment options for patients with neck and/or back problems, as well as brain and head injuries. He has also been featured in the scientific community, has authored textbook chapters in regenerative medicine, and is working on an anti-aging “how to” book called “Young Again” and his course “GET YOUNG AGAIN, the METHOD. He states “I am one of the few who thinks that stem cells are yesterday's longevity trend in the area of regenerative medicine. I am a proponent of stem cell derived exosomes. This is not just for longevity!” PODCAST INFO:The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKSSpotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRHRSS: https://www.learningwithlowell.com/feed/podcast/Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com Jeff Gross Linkshttps://ifixspines.com/https://pressrelease.healthcare/jeffrey-d-gross-md-a-neurosurgeon-with-spine-and-recellebrate.htmlhttps://www.linkedin.com/groups/14074103/ Timestamps00:00 Start00:25 Jousting injury02:30 Benefit of modern day leeching on health03:15 Benefits of plasma donation on health05:45 Human regeneration / health08:00 Exercise /muscle impact on brain health09:45 Why Women living longer / bone density / muscle12:22 Exercise & supplements to help women / improve health13:30 Men when to check hormones16:25 Bryan Johnson/ genetic testing18:00 Advice for Bryan Johnson20:20 How to help back pain / strength spine tips23:00 Exercises for spine27:00 How to improve neck pain28:36 Thoughts on shoes for spine / back health31:00 Back pain is not inevitable34:00 Working on back muscles34:45 Sleeping for back health36:00 Disk health of back and how to improve37:55 Reversing spine damage40:40 Regenerative medicine in US44:00 Stem cells / Exosomes benefits47:45 How to make us like Captain america / wolverine50:20 outcome differences for exosomes/ stem cells with injury52:00 Sport athletes / injury53:45 Stem cells / exosomes for getting healthy faster / examples in practice57:00 Exosomes explained and impact01:02:40 Taking exosomes regularly / biohacking01:04:10 Cost of exosomes01:06:45 Lethal dose / diminishing returns of exosomes01:08:20 Exosome injections01:11:06 Healthier now he has been in decades01:12:16 Designer exosomes / future research and practice opportunities01:15:12 Significance of designer exosomes01:17:55 How to learn about designer exosomes, regeneration, longevity interventions01:21:20 Strategies to get the most from papers01:26:20 Strategies / questions for when you're seeing your doctor01:30:32 Book recommendations01:32:55 Hate / love prior authorizations01:36:10 Private equity in practices01:36:50 When was he happiest in life01:38:30 Cutting edge scientist from outside of companies longevity #regeneration #exosomes
In this special replay episode of GRUFFtalk: How to Age Better, host Barbara Hannah Grufferman takes a deep dive into the amazing world of the skin microbiome with renowned dermatologist, TV personality, and author, Dr. Doris Day. Together they uncover the secrets to healthy, glowing skin as we discuss the ins and outs of the skin's microbial ecosystem: from understanding the influence of the skin microbiome on various skin conditions to exploring effective strategies for maintaining a balanced and thriving microbiome. But they also delve into eating the right foods, how external influencers (pollution, stress, and so on) can impact skin, and Dr. Day shares why she's such a big believer in intermittent fasting. Your skin will definitely thank you for tuning in to this episode! Key Links: Learn more about Dr. Doris Day: Website: https://dorisdaymd.com New Book—“Rebooting the Biome”: https://www.amazon.com/Rebooting-Biome-Properly-Skincare-Ingredient/dp/1990830196/ref=sr_1_1?crid=3GHGUKYM6HJOS&keywords=reboot+your+biome&qid=1689713613&sprefix=reboot+your+biome%2Caps%2C75&sr=8-1 The Role of Retinol: https://www.harpersbazaar.com/beauty/skin-care/a42749388/retinol-for-skin-care-wrinkles-acne-explained/ What is the Mtor Signaling Pathway? https://www.news-medical.net/life-sciences/What-is-the-mTOR-Signaling-Pathway.aspx Intermittent Fasting 101: https://www.healthline.com/nutrition/intermittent-fasting-guide Can Metformin Extend the Healthspan and Lifespan?: https://fortune.com/well/2023/05/04/metformin-anti-aging-longevity-risks-side-effects/# Understanding Exosomes: https://www.allure.com/story/exosome-therapy-for-skin-review#:~:text=Exosome%20therapy%20allows%20new%20exosomes,%2C%20strengthen%2C%20and%20rejuvenate%20skin. Past Episodes with Dr. Doris Day: Hair Loss: https://podcasts.apple.com/us/podcast/why-hair-loss-happens-and-what-to-do-about-it-with-dr-doris-day/id1623436268?i=1000628416064 Have questions or comments? Or maybe you have an idea for a topic or a guest you would like to see on the show? Email Barbara at grufftalkpodcast@gmail.com or connect with her on social media: Website: https://www.barbarahannahgrufferman.com Facebook: https://www.facebook.com/BarbaraHannahGruffermanAuthor Instagram: https://www.instagram.com/barb arahannahgrufferman/ Learn more about your ad choices. Visit megaphone.fm/adchoices
Prepare to unlock the secrets of your skin's potential as we welcome Alisa Lask, CEO of Rion Aesthetics, into a world where cardiology meets beauty to revolutionize your skincare routine. Alisa takes us through her transformative journey into the aesthetics field and unveils how a cardiologist's research paved the way for today's most innovative skincare solutions. We delve deep into the science of human biology, discussing breakthroughs that harness the power of platelet-derived exosomes – our body's natural healers. This episode promises to shift your perspective on the power of human-derived ingredients and their remarkable ability to regenerate and renew your skin, marking a new era in skincare innovation.Amid the science, we don't lose sight of the practical side – the art of skincare application. Alisa sheds light on the synergy between Rion's exosome technology and retinoids, a ray of hope for those battling irritation, and emphasizes the meticulous dance of applying products to maximize benefits. We cap off our conversation by celebrating Rion's commitment to age-appropriate skincare solutions, their 'trademark renewal zone technology', and the significance of antioxidants in their skincare line. With a nod to sustainability, we applaud Rion's introduction of refillable products, illustrating their ethical and rapid stride forward in the medical-grade skincare industry. Join us for a session that's not only enlightening but also redefines your skincare practices for the better.Support the showFollow The Show On All Socials Using The Tag @skincareanarchy
Are you fascinated by the incredible world of regenerative medicine? If so, you've probably come across the buzz about exosomes! These tiny extracellular vesicles, secreted by various cells in the body, play an important role in cell-to-cell communication and tissue repair. Research is underway studying stem cells and their exosomes to be able to deliver important cellular instructions for various organs, including the skin. Exosome therapy is a bit like the wild west however as it remains largely unregulated at this time so be sure to do your research! Discover the world of exosomes with Dr. Russak on this week's podcast episode! From their sources to application methods and ethical concerns, we take a deep dive into this cutting-edge skincare science. In this episode: 1. What are exosomes? What do they do? (5:30) 2) How do we get exosomes? (7:24) 3) What conditions in dermatology can we treat using exosomes? (10:12) 4) Limitations and ethical concerns with exosomes (15:15) 5) Can someone buy products with exosomes from a drug store? (17:48) 6) Are exosomes shelf stable or do they have to be refrigerated? (19:40) 7) The future of exosomes (21:15) 8) Tips for someone considering exosome therapy (26:30) Julie E. Russak, M.D., FAAD., is a Board-Certified Dermatologist, Fellow of the American Academy of Dermatology, serves as Faculty at the Mount Sinai Hospital, and founder of Russak Dermatology Clinic and Russak+ Aesthetic Center. She founded her private practice, Russak Dermatology Clinic, in 2013 in midtown Manhattan to fulfill her goal of providing comprehensive medical and cosmetic skin care to her patients. In addition to her excellence as a dermatologic surgeon, Dr. Russak has distinguished herself in the medical community through her clinical research, scientific presentations, publications and aesthetic approach. Find Dr. Russak here:- https://www.instagram.com/russakderm/ https://russakplus.com/ Follow Dr. Mina here:- https://instagram.com/drminaskin?igshid=OGQ5ZDc2ODk2ZA== For more great skin care tips, subscribe to The Skin Real Podcast or visit www.theskinreal.com Baucom & Mina Derm Surgery, LLC Email - scheduling@atlantadermsurgery.com Contact - (404) 844-0496 Instagram - @baucomminamd Thanks for listening! The content of this podcast is for entertainment, educational, and informational purposes and does not constitute formal medical advice.
Researchers define a nanopipette fabrication protocol for high resolution cell imagingTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Yasufumi Takahashi at the Kanazawa University NanoLSI.The research described in this podcast was published in Analytical Chemistry in August 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Researchers define a nanopipette fabrication protocol for high resolution cell imagingResearchers at Kanazawa University report in Analytical Chemistry how to produce nanopipettes that reliably provide nanoscale resolution scanning ion conductance microscopy images of living cells.A nanoscale view of living cells can provide valuable insights into cell structure and function. Over the years, various microscopy techniques have been enrolled to obtain a window into biological specimens at the nanoscale but all with their limitations and challenges. Although scanning ion conductance microscopy has demonstrated the capability to image living biological samples in solution with nanoscale resolution, it has been hampered by challenges in reliably producing nanopipettes with the optimum geometry for the job. Now researchers led by Yasufumi Takahashi at Kanazawa University's Nano LSI and Nagoya University have devised a protocol for reproducibly fabricating nanopipettes with the preferred geometry for high quality imaging. So what is scanning ion conductance microscopy and what kind of nanopipette does it need?Scanning ion conductance microscopy uses a nanopipette to control the distance between nanopipette and sample using an ion current as feedback signal. The shape of the nanopipette significantly influences the performance of the device. For instance, a wide aperture limits the possible resolution, a long shunt can lead to rectification effects that warp the ion current measurements, and if the glass of the nanopipette is too thick it can deform the sample before the proximity of the aperture has reached the point needed for constant ion current topographical mapping. As a result, the ideal nanopipette has a short shunt, small aperture and thin glass walls.The standard procedure for fabricating the nanopipette is to pull a capillary tube with a laser puller that heats the capillary tube it is manipulating. The capillary then narrows where it lengthens until it is finally drawn into two separate pieces. Although quartz can allow a little more control in the process of drawing the capillary tube into shape it is hydrophobic, which raises complications in actually filling the nanopipette with the aqueous solution needed for the ion current. For this reason, the researchers developed a protocol by which they could draw nanopipettes from borosilicate glass capillaries with the required control and reproducibility.Takahashi and his collaborators noted that ideally the starting capillary should have thick walls and a narrow inner diameter, however it is not easy to obtain capillary tubes to these requirements from commercial suppliers. Instead, they preheat the capillary for 5 s without pulling it, which causes the glass walls to the thicken and reduces the inner diameter. They also optimized the parameters for pulling the tube, such as the velocity.So did it work? Apparently soThe researchers demonstrated the performance of the nanopipettes they produced by imaging a cell undergoing a type of endocytosis, where it engulfs and absorbs some external material. They were able to image the microvilli – that is, tiny cellular membrane protrusions – found on the cell surface, as well as the endocytic pits that NanoLSI Podcast website
Exosome นวัตกรรมในการฟื้นฟูและบำรุงร่างกายที่กำลังได้รับความนิยมอย่างมาก ไม่ว่าจะเป็นการฟื้นฟูผิวให้ดูอ่อนเยาว์ รักษาปัญหาหัวล้าน หรือลดอาการปวดเข่า แต่จริงๆ แล้ว Exosome คืออะไร มีประโยชน์อย่างไร และได้รับการรับรองมาตรฐานในการใช้งานหรือไม่ Top to Toe เอพิโสดนี้ พามารู้จัก Exosome ที่ไม่เพียงแต่เป็นประเด็นในวงการความงามเท่านั้น แต่ยังเป็นส่วนสำคัญในวิทยาการทางการแพทย์ รวมไปถึงเบื้องหลังธุรกิจการผลิตและการวิจัย Exosome ที่จะช่วยให้เรามีข้อมูลมากเพียงพอก่อนที่จะตัดสินใจฉีด Exosome เข้าสู่ร่างกาย
In this episode Dr. Masha and Dr. Richard Ambrozic are discussing regenerative medicine, in particular Exosomes and Stem cell therapy. After listening to this episode you will understand the difference between these two therapies, who can benefit from these therapies and how to combine it with HBOT to decrease pain, improve mobility, and for an injury recovery ► Contacts: Dr. Rick Ambrozic, MD on Instagram: https://www.instagram.com/drrick/ Dr. Ambrozic' website: http://www.iwcusa.com/ Timestamps: 00:00 INTRO 01:44 Exosome therapy vs Stem cell therapy 02:41 Exosome therapy: results 04:53 How it works with Hyperbaric Therapy 11:09 Infertility treatment 12:09 The most effective combination 12:54 Contraindications 14:53 Side effects 17:22 Anti-aging effect ► Stay Updated With Our 'How to HYPERBARIC' Newsletter: https://mailchi.mp/e04a3f427054/how-to-hyperbaric-newsletter ► To learn how Hyperbaric Therapy can help you and where to start, book your Hyperbaric Oxygen Therapy consultation with Dr. Masha: https://drmasha.com/hbot/ ► This podcast season's focus is on natural therapies that can be effectively combined with Hyperbaric Oxygen Therapy. LET'S STAY IN TOUCH: ► How to Hyperbaric on Instagram: https://www.instagram.com/how_to_hyperbaric/ ► Subcribe to my YouTube channel: https://www.youtube.com/channel/UCLMVcniuFse9B6XMKhg1_aw/featured?sub_confirmation=1 ABOUT ME: I'm Dr. Masha, Naturopathic doctor and Hyperbaric expert. I teach how to integrate natural therapies with lifestyle changes to regain health, live longer and be healthy for as long as possible. I have a special interest in Hyperbaric Oxygen Therapy and I am on a mission to raise awareness about the benefits of HBOT. I host 'How to HYPERBARIC" podcast, a leading podcast about Hyperbaric Therapy. DISCLAIMER: This “How to HYPERBARIC” Podcast is for informational purposes only. Statements and views expressed on this podcast are not medical advice. This podcast disclaims responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guests' qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician. #hyperbaricoxygentherapy #exosomes #stemcellstherapy #drmasha #hyperbaricchamber #hbot #regenerativetherapy
I recently had the pleasure of speaking with Dr. Jeffrey Gross, a fascinating guest who is on the cutting edge of regenerative medicine and biohacking. Dr. Gross joined me on The Over 50 Health & Wellness Podcast to discuss how we can use science and technology to optimize our health. Dr. Gross is a board-certified neurological surgeon with over 25 years of experience helping patients avoid unnecessary surgeries. More recently, he has focused on anti-aging strategies and founded ReCELLebrate Health to provide regenerative therapies. On the podcast, Dr. Gross outlined some incredible innovations that left my mind blown! We covered emerging treatments like: - PRP (platelet rich plasma) injections- Stem cell therapies - Exosome treatments He explained how these treatments utilize the body's own healing systems to reduce inflammation, repair joints, and even turn back aging. I was fascinated to learn how a simple IV infusion of something called “extracellular vesicles” can make people feel energized, refreshed, and reduce aches and pains. According to Dr. Gross, the science shows these regenerative treatments can potentially help with conditions ranging from arthritis to neurological diseases to cosmetic anti-aging. While not currently approved by the FDA, they are widely available, especially for biohackers and athletes looking for an edge. Listen to this trailblazing episode for a glimpse into the exciting possibilities of biohacking your health for longevity! Dr. Gross provides an expert perspective on how these cutting-edge therapies work and what the future may hold as the research continues to progress. If overcoming health challenges and living longer through science sounds compelling, you won't want to miss this episode! You can connect with Dr. Gross and ReCELLebrate in the following ways: Main Website:https://recellebrate.com(mention you heard about ReCELLebrate form the pod for free intro call) Free Longevity Supplement Guide:https://www.youngagainmethod.com/longevity YouTube:https://www.youtube.com/@stemcellwhisperer LinkedIn:https://www.linkedin.com/in/jeffrey-gross-md-5605605 Instagram - @recellebrateTikTok - @recellebrate Ready to rewrite the narrative of your life and health? Visit the link below to see if our bespoke coaching services align with your vision: https://calendly.com/thesilveredge/coaching-inquiry Longing for more wisdom on health and wellness in your golden years? Dive into our exclusive Facebook group: https://www.facebook.com/groups/silveredgefitness
We're welcoming Alisa Lask, the CEO of Rion Aesthetics, to the show today. She has over two decades of experience in this industry, spanning across pharmaceuticals, medical devices, and cosmeceuticals. Our focus in today's discussion is Rion's revolutionary ( plated ) Skin Science products. You'll know by listening to this episode that the future is here. When she ventured into skincare, Alisa thought exosomes were useless because of her science-based background. After a doctor that she trusts really recommended them, Alisa used them for 5 months and realized that the science behind them is amazing. After explaining what exactly exosomes are, Alisa takes us through the different ( plated ) Skin Science offerings from Rion. Some of the most common feedback about ( plated ) is appreciation of the source material of the product being so transparent. Also, providers are saying that by using this product, they're able to simplify skincare routines. Exosomes are so extremely small, and very sophisticated machinery is needed to extract them properly for use on your skin. Rion's products do not contain anything else, such as DNA, which is quite mind-blowing given their size. There are a lot more exciting things coming from Rion, and Alisa provides a timeline of what we can expect. Still, they're focused on not getting too big too fast. Their long-term goal is to help advance aesthetics, especially in the regenerative space. Stimulating tissue to grow collagen and elastin on its own is so much more effective than using filler. www.rionaesthetics.com www.platedskinscience.com www.beautyculturespa.com @beautyculture.medspa
Your Infinite Health: Anti Aging Biohacking, Regenerative Medicine and You
Regenerative medicine is revolutionizing the way we approach Parkinson's disease, offering hope to those living with the condition and their caregivers.In this episode, Dr. Trip Goolsby discusses the promising use of regenerative medicine in reversing Parkinson's disease symptoms. Exosome therapies, derived from biological nanoparticles, have shown positive results in early and moderate stages of the disease. Dr. Goolsby explains that these exosomes, containing regenerative molecules, can be administered through a micronized nasal spray, allowing them to specifically target and repair areas of inflammation and damage in the brain. This breakthrough in regenerative medicine offers hope to those living with Parkinson's disease and their caregivers.Dr. Trip Goolsby & LeNae Goolsby are the co-founders of the Infinite Health Integrative Medicine Center, and are also the co-authors of the book “Think and Live Longer”TakeawaysExosome therapies hold potential for reversing Parkinson's symptoms.Micronized nasal spray precisely delivers exosomes to the brain.Regenerative medicine could transform Parkinson's treatment, addressing underlying damage, unlike current symptomatic approaches.ConnectDr. Trip Goolsby: https://www.linkedin.com/in/trip-goolsby-96669023/LeNae Goolsby: https://www.linkedin.com/in/lenae-goolsby/Instagram: https://www.instagram.com/your.infinite.health/Facebook: https://www.facebook.com/InfiniteHealthIMCResourcesWebsite: www.YourInfiniteHealth.comTwitter: https://twitter.com/URInfiniteLifeBook: Think & Live Longer on AmazonConnectDr. Trip Goolsby & LeNae Goolsby are the co-founders of the Infinite Health Integrative Medicine Center, and are also the co-authors of the book “Think and Live Longer”.
How can regenerative medicine, like stem cell and exosome treatment, relieve arthritis? Could stem cells help repair a vision-impaired eye or a nerve-damaged spine? On VitalSigns, Dr. Damon Noto explains to host Brendon Fallon how regenerative medicine can be used to counter osteoarthritis. But the possibilities go well beyond that. “Within 48 hours, if we'd had the ability to put stem cells into that area of trauma, he may not have been paralyzed,” Dr. Noto says of 1970s–80s Superman star, Christopher Reeve, whose horse-riding accident left him paralyzed. Dr. Noto is a physical and regenerative medicine specialist who has helped patients recover health and function in joints and other areas through stem cell, exosome, PRP, and related treatments. “When you have trauma, those stem cells go into that area. And then [they're] like the foreman telling people what to do: ‘Hey, lay down fibrin here, lay down cartilage here; we need to grow blood vessels!'” What prospects does regenerative medicine offer for reversing aging and disability in the future? Why hasn't the technology of stem cells advanced as fast as expected? ⭕️ Watch in-depth videos based on Truth & Tradition at Epoch TV
In this episode, the hosts have an intriguing discussion with Dr. Ben Sun, Head of Biomarker Genetics at Biogen. Dr. Sun holds an MD/PhD from the University of Cambridge, providing a view and perspective on data from both research and clinical perspectives. The advantage of his unique background is that it provides a balanced perspective on large-scale population data and genomic data sets used to train computational models for predicting and informing clinical treatment. The conversation touches on the fundamental science as well as the integration of in silico, in vitro, and in vivo methods. Ben also shares insights on decision-making is different in research vs. clinical spaces and on the types of variations that can make it challenging to train and confidently use AI in healthcare. Subscribe to be notified when future episodes drop. For full access to the video and transcripts, please visit our Thermofisher page directly at https://www.thermofisher.com/us/en/home/global/forms/life-science/subscribe-speaking-mol-bio-podcast.html In the meantime, we hope you'll share our podcast with a friend or colleague that might enjoy it. And as you progress in your own work, we hope you'll visit the Invitrogen School of Molecular Biology (https://thermofisher.com/ISMB) where you can access molecular biology resources to help you achieve your goals.
In this week's episode of GRUFFtalk: How to Age Better, host Barbara Hannah Grufferman takes a deep dive into the amazing world of the skin microbiome with renowned dermatologist, TV personality, and author, Dr. Doris Day. Together they uncover the secrets to healthy, glowing skin as we discuss the ins and outs of the skin's microbial ecosystem: from understanding the influence of the skin microbiome on various skin conditions to exploring effective strategies for maintaining a balanced and thriving microbiome. But they also delve into eating the right foods, how external influencers (pollution, stress, and so on) can impact skin, and Dr. Day shares why she's such a big believer in intermittent fasting. Your skin will definitely thank you for tuning in to this episode! Key Links: Learn more about Dr. Doris Day: Website: https://dorisdaymd.com New Book—“Rebooting the Biome”: https://www.amazon.com/Rebooting-Biome-Properly-Skincare-Ingredient/dp/1990830196/ref=sr_1_1?crid=3GHGUKYM6HJOS&keywords=reboot+your+biome&qid=1689713613&sprefix=reboot+your+biome%2Caps%2C75&sr=8-1 The Role of Retinol: https://www.harpersbazaar.com/beauty/skin-care/a42749388/retinol-for-skin-care-wrinkles-acne-explained/ What is the Mtor Signaling Pathway? https://www.news-medical.net/life-sciences/What-is-the-mTOR-Signaling-Pathway.aspx Intermittent Fasting 101: https://www.healthline.com/nutrition/intermittent-fasting-guide Can Metformin Extend the Healthspan and Lifespan?: https://fortune.com/well/2023/05/04/metformin-anti-aging-longevity-risks-side-effects/# Understanding Exosomes: https://www.allure.com/story/exosome-therapy-for-skin-review#:~:text=Exosome%20therapy%20allows%20new%20exosomes,%2C%20strengthen%2C%20and%20rejuvenate%20skin. Past Episodes with Dr. Doris Day: Hair Loss: https://podcasts.apple.com/us/podcast/grufftalk-how-to-age-better-with-barbara-hannah-grufferman/id1623436268?i=1000577771641 Have questions or comments? Or maybe you have an idea for a topic or a guest you would like to see on the show? Email Barbara at grufftalkpodcast@gmail.com or connect with her on social media: Website: https://www.barbarahannahgrufferman.com Facebook: https://www.facebook.com/BarbaraHannahGruffermanAuthor Instagram: https://www.instagram.com/barb arahannahgrufferman/ Learn more about your ad choices. Visit megaphone.fm/adchoices
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.12.548710v1?rss=1 Authors: Meneses-Salas, E., Arnold, M., Hsieh, F., Enrich, C., Pfeffer, S. R., Merchant, K. M., Lu, A. Abstract: Background: The endo-lysosomal phospholipid, bis(monoacylglycerol)phosphate (BMP), is aberrantly high in the urine of Parkinson's patients with mutations in genes encoding leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase). Because BMP resides on and regulates the biogenesis of endo-lysosomal intralumenal membranes (exosomes when released), we hypothesized that elevated urinary BMP may be driven by increased exocytosis of BMP-enriched exosomes. Objective: Our aim was to explore the contribution of LRRK2 and GCase activities in the regulation of BMP metabolism and release. Methods: Microscopy and biochemical assays were used to analyze antibody-accessible BMP and exosome release in wild type (WT) and R1441G LRRK2-expressing mouse embryonic fibroblast cells. Lipidomics analysis was conducted to measure BMP and lipid content in cells and isolated exosomes. In these experiments, we tested the effects of LRRK2 and GCase inhibitors, MLi-2 and conduritol {beta}-epoxide respectively, to assess regulation of BMP by LRRK2 and GCase. Results: Alterations in antibody-accessible BMP and endo-lysosome morphology were detected in R1441G LRRK2 cells. Lipidomics analysis revealed increased BMP content in mutant LRRK2 MEFs compared to WT MEFs. Inhibition of LRRK2 partially restored cellular and exosome-associated BMP levels; abrogation of GCase activity had the opposite effect. Metabolic labeling experiments confirmed that BMP synthesis is not influenced by LRRK2 or GCase activities. Pharmacological modulation of exosome release further confirmed exosome-mediated BMP exocytosis. Conclusions: LRRK2 regulates BMP in cells and its release in exosomes, which can be further modulated by GCase activity. These results have implications for the use of exosomal BMP as a Parkinson's disease biomarker. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
NAD, Intravenous laser therapy, Plasmapheresis, Exosome หัตถการความงามที่กำลังฮิตอยู่ในตอนนี้สรุปดีจริงมั้ย? แล้วมีอะไรที่เป็นข้อควรระวังหรือเปล่า? หมอผิงและหมอจั๊ด นพ.ชลธวัช สุวรรณปิยะศิริ จะพาคุณไปฟังความจริง รวบรวมมาให้หมดที่ Podcast Episode นี้ค่ะ ห้ามพลาดเลยนะคะ!!
Reference The International Journal of Biochemistry& Cell BiologyVolume 114, 105564. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
Join us for this powerful discussion with Dr. Jeffrey Gross, a neurosurgeon and regenerative medicine expert. He is on a mission to get the message out in regards to the blossoming field of anti-aging, regenerative medicine, and spinal disc regeneration. Dr. Gross has been featured in the scientific community and is currently working on an anti-aging book called "Young Again." He shares the biggest drivers for chronic pain, the role of inflammaging, top lifestyle recommendations, the use of stem cells & exosomes, and more on precision medicine care. A board-certified and fellowship-trained neurosurgeon, Dr. Gross is the Owner of SPINE, and a regenerative medicine practice called ReCELLebrate, is seeing patients in Orange County, California, and in Henderson, Nevada, as well as remotely by computer video conference. In his practice, he offers specialized precision and concierge treatment options for patients with neck and/or back problems, as well as brain and head injuries. He provides a comprehensive approach to evaluating the pain generators of the spine and associated areas, and digs deeper to find the source of the problem when identifying the root issues of persistent pain and injuries. SHOW NOTES:0:51 Welcome to the show!1:20 Pop Quiz of the Day3:35 Addressing dopamine addictions4:38 Today's topic: Regenerative Medicine6:36 Dr. Jeffrey Gross' bio8:43 Welcome him to the show!9:45 How often are we performing unnecessary surgeries?11:12 Renee's spine injury13:00 What is causing chronic pain?14:55 Is inflamm-aging the biggest cause?16:12 What have we gotten wrong about movement?17:32 Healthspan Summit18:15 Alzheimer's prevention19:40 Our Great Aunt Kay20:12 Number two pillar: nutrition21:20 Supplements to support inflammation22:48 What happens to our stem cells as we age?25:10 Different levels of Regenerative Medicine26:08 The Vampire Facial26:23 Injecting Stem Cells29:47 *LightPath LED*33:02 All about Exosomes38:15 *Magnesium Breakthrough*40:04 How are the Exosomes delivered?41:45 Treating spine degeneration45:10 Our Dad's knee surgery46:32 Addressing nerve involvement & PAIN50:13 Building good abdominal strength57:16 Additional biohacks to support recovery 1:01:10 Exosome injections & supplements1:05:07 His final piece of advice1:06:00 Where to find Dr. Gross1:07:42 Thanks for tuning in!RESOURCES:Podcasts: Recellebrate Stem CellsBlogs: https://recellebrate.com/blog/Fun promo video: https://www.youtube.com/watch?v=dFQDMTfw1rELightPathLED - Save 5% with discount code: BIOHACKERBABEESMagnesium Breakthrough - Save 10% with discount code - BIOHACKERBABES10Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands
Automated Microneedling utilizes tiny needles which penetrate into the skin at very fast rates (from 100 to 150 hz or repetition rate).These tiny needle insertions create pinpoint bleeding which initiates the wound healing cascade to stimulate elastin and collagen.This episode discusses the Exceed MN Pen and discusses pre-treatment recommendations as well as post treatment care.We like to utilize Exosomes post treatment (refer to episode #12 for more info on exosomes).Enjoy! Thank you for your listenership!
Hair loss is bigger in females than most people realize and many women don't realize there are solutions. Dr. Champagne is back for part two to share. What are the first steps for women with thinning hair? Red Laser Caps, Dermarolling, PRP injections, Exosome therapy, topical solutions, medications and vitamins and other non surgical, affordable solutions to hair loss. How can these be used as alternatives to surgery or even in combination? Hint: one modality alone is not enough. How to find a reputable surgeon in your area and the questions to ask when you do. Fees and recovery times. Why going oversees to save money could cost you much MUCH more. The differences (pros and cons) between FUE and FUT surgical procedures that you need to know. Does any of this work in cases of Alopecia? Male vs. Female hair loss and how treating them could be different. HEAL SQUAD SOCIALS IG: @HealSquad TikTok: @HealSquadxMaria APPLE PODCASTS: https://podcasts.apple.com/us/podcast/heal-squad-x-maria-menounos/id1320060107 SPOTIFY: https://open.spotify.com/show/2kXrmaNDQQ4i6prZe6LO89?si=19af23c6154943d0 HEAL SQUAD RESOURCES: Website: www.mariamenounos.com Curated Macy's Page: macys.com/healsquad Amazon Storefront: https://www.amazon.com/shop/mariamenounos Patreon: https://patreon.com/HealSquad?utm_medium=clipboard_copy&utm_source=copyLink&utm_campaign=creatorshare_creator&utm_content=join_link ABOUT MARIA MENOUNOS: Emmy Award-winning journalist, TV personality, actress, 2x NYT best-selling author, former pro-wrestler and brain tumor survivor, Maria Menounos' passion is to see others heal and to get better in all areas of life. ABOUT HEAL SQUAD x MARIA MENOUNOS: A daily digital talk-show that brings you the world's leading healers, experts, and celebrities to share groundbreaking secrets and tips to getting better in all areas of life. DISCLAIMER: This Podcast and all related content [published or distributed by or on behalf of Maria Menounos or Mariamenounos.com] is for informational purposes only and may include information that is general in nature and that is not specific to you. Any information or opinions expressed or contained herein are not intended to serve as or replace medical advice, nor to diagnose, prescribe or treat any disease, condition, illness or injury, and you should consult the health care professional of your choice regarding all matters concerning your health, including before beginning any exercise, weight loss, or health care program. If you have, or suspect you may have, a health-care emergency, please contact a qualified health care professional for treatment. Any information or opinions provided by guest experts or hosts featured within website or on Company's Podcast are their own; not those of Maria Menounos or the Company. Accordingly, Maria Menounos and the Company cannot be responsible for any results or consequences or actions you may take based on such information or opinions.
Dr. Linda Marbán, Ph.D., CEO of Capricor Therapeutics, a clinical-stage biotech focused on the development of cell and exosome-based therapeutics for the treatment and prevention of serious diseases, joins Cell & Gene: The Podcast's Erin Harris to discuss the current state and the near-term future of exosomes. Marbán discusses Capricor's exosome program and the company's proprietary allogeneic cardiosphere-derived cells (CDCs) and engineered exosomes. She also covers the company's HOPE clinical trial series' progress to treat Duchenne muscular dystrophy (DMD).
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.04.535541v1?rss=1 Authors: Wells, A., Mendes, C. C., Castellanos, F., Mountain, P., Wright, T., Wainwright, S. M., Stefana, M. I., Harris, A. L., Goberdhan, D. C. I., Wilson, C. Abstract: Secretory cells in glands and the nervous system frequently package and store proteins destined for regulated secretion in dense-core granules (DCGs), which disperse when released from the cell surface. Despite the relevance of this dynamic process to diseases such as diabetes and human neurodegenerative disorders, our mechanistic understanding is relatively limited, because of the lack of good cell models to follow the nanoscale events involved. Here, we employ the prostate-like secondary cells (SCs) of the Drosophila male accessory gland to dissect the cell biology and genetics of DCG biogenesis. These cells contain unusually enlarged DCGs, which are assembled in compartments that also form secreted nanovesicles called exosomes. We demonstrate that known conserved regulators of DCG biogenesis, including the small G-protein Arf1 and the coatomer complex AP-1, play key roles in making SC DCGs. Using real-time imaging, we find that the aggregation events driving DCG biogenesis are accompanied by a change in the membrane associated small Rab GTPases which are major regulators of membrane and protein trafficking in the secretory and endosomal systems. Indeed, a transition from trans-Golgi Rab6 to recycling endosomal protein Rab11, which requires conserved DCG regulators like AP-1, is essential for DCG and exosome biogenesis. Our data allow us to develop a model for DCG biogenesis that brings together several previously disparate observations concerning this process and highlights the importance of communication between the secretory and endosomal systems in controlling regulated secretion. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Dr. Claudia Benavente studied Molecular Biotechnology Engineering at Universidad de Chile where her interest in pursuing cancer research first started. To further her studies, she came to the US to pursue a doctoral degree in Cancer Biology at The University of Arizona as a Fulbright scholar. She then moved on as a postdoctoral fellow to St. Jude Children's Research Hospital in Memphis, TN where she became familiar with childhood solid tumors. Professor Benavente is currently an Associate Professor at the Departments of Pharmaceutical Sciences and Developmental and Cell Biology and a member of the Chao Family Comprehensive Cancer Center at the University of California, Irvine. Dr. Benavente's research focuses on understanding how pediatric tumors form to design new ways to treat them. Her research aims to understand how genes are normally controlled in developing tissues and how epigenetic processes are perturbed to facilitate cancers to arise. This information guides her in the development of new therapies. --- What We Do at MIB Agents: PROGRAMS: ✨ End-of-Life MISSIONS ✨ Gamer Agents ✨ Agent Writers ✨ Prayer Agents ✨ Healing Hearts - Bereaved Parent Support ✨ Ambassador Agents - Peer Support ✨ Warrior Mail ✨ Young Adult Survivorship Support Group ✨ EDUCATION for physicians, researchers and families: ✨ OsteoBites, weekly webinar & podcast with thought leaders and innovators in Osteosarcoma ✨ MIB Book: Osteosarcoma: From our Families to Yours ✨ RESEARCH: Annual MIB FACTOR Research Conference ✨ Funding $100,000 annually for OS research ✨ MIB Testing & Research Directory ✨ The Osteosarcoma Project partner with Broad Institute of MIT and Harvard ... Kids are still dying with 40+ year old treatments. Help us MakeItBetter.
This episode is brought to you by Rupa Health and Athletic Greens.You can dramatically increase your healthspan through diet, exercise, and lifestyle, and that's enough to feel younger for longer! But if you're interested in taking your longevity protocol to the next level, there are many advanced longevity innovations coming online and giving insight into the future of longevity.In today's episode of my series I'm calling Health Bites, I dive into exciting new advances to optimize health and increase longevity. What I've discovered has blown my mind and changed the way I approach my own health and the health of my patients. I've compiled it all into a new book called Young Forever, which is out now. Learn more and order the book at youngforeverbook.com.This episode is brought to you by Rupa Health and Athletic Greens.Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 35 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.AG1 contains 75 high-quality vitamins, minerals, whole-food sourced superfoods, probiotics, and adaptogens to support your entire body. Right now when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting athleticgreens.com/hyman.Here are more details from our interview (audio version / Apple Subscriber version):Stem cell therapy (4:50 / 2:45) Exosome therapy (8:05 / 5:50) My own experience using exosomes (9:07 / 6:52)Peptide therapy (11:39 / 9:23) My personal use of peptides (13:34 / 10:07) Regenerative medicine: what it is and my own experience using it (14:03 / 11:48) Mentioned in this episodeBioReset Medical Hosted on Acast. See acast.com/privacy for more information.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.23.529257v1?rss=1 Authors: Bebelman, M. P., Crudden, C., Snieder, B., Thanou, E., Langedijk, C. J. M., Viola, M., Eleonora, S., Baginska, U., Cotugno, O., Bebelman, J. P. M., van Eijndhoven, M. A. J., Bosch, L., Li, K. W., Smit, M. J., van Niel, G., Smit, A. B., Verweij, F. J., Pegtel, D. M. Abstract: Dysregulated extracellular vesicle (EV) release has been implicated in various pathologies, including cancer, neurodegenerative disease and osteoarthritis. Despite clear therapeutic potential, drug screening for EV release modulators has yielded limited success due to the lack of a sensitive and scalable EV read-out system. Here, we employed CRISPR-Cas9 to engineer HEK293 cells expressing HA-NanoLuciferase-(NL)-tagged endogenous CD63. We found that under basal culture conditions, CD63-containing EVs are released via a mechanism that is independent of the exocytic SNARE protein SNAP23, presumably by direct budding from the plasma membrane. Endo-lysosome inhibition by chemical or genetic perturbation of vATPase strongly increased SNAP23 and nSmase2-dependent exosome secretion from intracellular compartments. Proteomic analysis revealed these exosomes are enriched for early- and late endosomal markers, but also for autophagosomal proteins. This suggests that a proportion of these exosomes originate from amphisomes, although chemical inhibition of canonical autophagy did not affect exosome secretion upon lysosome inhibition. Using a broad-spectrum kinase inhibitor screen, we identified and subsequently validated the lipid kinase PI4KIII{beta} as a critical mediator of exosome secretion and amphisome-mediated secretory autophagy, upon lysosome inhibition. We conclude that tagging of endogenous CD63 with NanoLuciferase represents a sensitive, scalable reporter strategy that enables identification of (druggable) modulators of EV biogenesis and release under physiological and pathological conditions. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.14.528554v1?rss=1 Authors: Jin, S., Chen, X., Tian, Y., Jarvis, R., Promes, V., Yang, Y. Abstract: Developing astroglia play important roles in regulating synaptogenesis through secreted and contact signals. Whether they regulate postnatal axon growth is unknown. By selectively isolating exosomes using size-exclusion chromatography (SEC) and employing cell-type specific exosome reporter mice, our current results define a secreted astroglial exosome pathway that can spread long-range in vivo and stimulate axon growth of cortical pyramidal neurons. Subsequent biochemical and genetic studies found that surface expression of glial HepaCAM protein essentially and sufficiently mediates the axon-stimulating effect of astroglial exosomes. Interestingly, apolipoprotein E (ApoE), a major astroglia-secreted cholesterol carrier to promote synaptogenesis, strongly inhibits the stimulatory effect of astroglial exosomes on axon growth. Developmental ApoE deficiency also significantly reduces spine density of cortical pyramidal neurons. Together, our study suggests a surface contact mechanism of astroglial exosomes in regulating axon growth and its antagonization by ApoE, which collectively coordinates early postnatal pyramidal neuronal axon growth and dendritic spine formation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
https://psychiatry.dev/wp-content/uploads/speaker/post-10914.mp3?cb=1669206634.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome – PubMed Jessica AFull EntryA blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome – PubMed
TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Click arrow to play Download TWiN 028 (77 MB .mp3, 64 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Glia 101 (TWiN 19) Oligodendrocytes enhance axonal energy metabolism (Neuron) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
Putting Manufacturing First: Codiak Moves Swiftly into Clinical Trials with Exosome-based Treatments Sriram Sathyanarayanan, Codiak's CSO, and Linda Bain, their CFO, share how the company moved into clinical trials in under 6 years. Exosomes, extremely small vesicles shed by all cell types, promise to become a viable delivery system for treatments of many diseases. But until recently, manufacturing them at a commercially viable scale has been unfeasible. That is why in 2015 the company Codiak took a two-pronged approach to developing exosome-based treatments: prioritizing both the engineering and manufacturing tracks from the outset. A mere six years after the company was launched, this approach has proven effective, with two promising studies in the clinic for tumor treatments, while most other developers are still at the starting blocks. The exosome field today holds the kind of promise that antibody and protein-based therapeutics did in the 1980s—the potential to improve both treatments and patient well-being is great. With a low risk of immunotoxicity, leveraging their natural abilities and engineering them to deliver targeted therapies could open new therapeutic pathways to previously undruggable targets. Yet as recently as only a couple of years ago, manufacturing exosomes was limited to small batches. Codiak has successfully increased production to thousand-liter batches, permitting clinical studies and greatly improving the prospective of widespread use. In collaboration with Lonza, Codiak is doubling down on their advantage with a recently established Center of Excellence for exosome manufacturing in Massachusetts. To learn more about Codiak's pipeline of therapeutic candidates with a potential to transform patients' lives, visit: https://www.codiakbio.com/pipeline-programs/pipeline Curious to Know More? Listen to Martina Hestericová's conversation with Sriram Sathyanarayanan and Linda Bain as they discuss the advantages of exosome treatments, how they are developed and why the company's early manufacturing strategy is paying off. KEY TERMS IN CONTEXT: Exosomes are nano-sized delivery vehicles generated by all eukaryotic cells. They are roughly between 30 and 120 nanometers large and originate when endosomes, or intercellular vesicles, are released into the blood, milk or tissue. Exosomes then become messengers and surrogates for the original cell. Their surface markers represent a location code and spread through the extracellular space in the body to communicate with other cells and deliver packages. Commercial exosome manufacturing is the scaling-up process of moving from small-batch exosome production that uses ultracentrifuges to large-scale production that in many ways resembles the processes already used to manufacture antibody and protein-based therapies. The exosome's lumen is the interior volume of the exosome where, through biological engineering, the therapeutic molecule can be placed. The molecule can also be on the surface of the exosome, allowing for two alternative payload capacities, depending on the target. Immunosafety and immunotoxicity refer to how potentially safe or toxic the immune system's reaction to a molecule may be. Since exosomes already have a history of low immunotoxicity – think of blood transfers – their immunosafety is already proven to be very high.
In Episode 86, I sit down with Dr. Andrew Doe who owns and operates Alate Health in Houston, Texas. I flew down and had a treatment done to my knees that will regenerate cartilage with the hopes of lessening the pain and increasing the functionality of my knees. Dr. Doe goes into detail regarding my specific treatment and talks about all the different aspects of stem cell, exosomes, and growth factor treatments. This was an incredible podcast because Dr. Doe is not only a physician, but a veteran and a blackbelt in jiu jitsu, so we had no shortage of things to talk about. Many of our listeners are athletes, first responders, and soldiers, and we put our body through the wringer, so be prepared to take copious notes! Please enjoy episode 86 of the Endless Endeavor Podcast. --- Connect with me Instagram: @granderson33 Website: www.theelectricnorth.com for podcast apparel and gear Email: gregandersonpodcast@gmail.com Linktr.ee: https://linktr.ee/Granderson33 Connect with Dr. Andrew Doe Website: www.alatehealth.com Instagram: @andrewldoe_md Email: Info@alatehealth.com Episode resources: Bio Pro + https://bioproteintech.com/product/biopro-plus coupon code ENDLESS saves $30 Moya Brand https://www.moyabrand.com Coupon ENDLESS 20% off Cured Nutrition https://www.curednutrition.com coupon ENDLESS 10% Off If you enjoy the show, make sure to give the Endless Endeavor Podcast a rating via your favorite audio platform OR on YouTube here: https://www.youtube.com/channel/UCieFsr26t9cyPDKMbLQJzXw/featured!
Aspen Institute for Anti–Aging And Regenerative Medicine (970-279-8348) in Denver, CO is known for its exosome treatments that use only cutting-edge technology for the immediate resolution of your chronic or acute pain. Learn more at https://aspen-regenerativemedicine.com (https://aspen-regenerativemedicine.com)
ReNeuron Group's Olav Hellebo joins Proactive to talk about their exosome technology which has shown it can deliver therapeutic proteins to a hard to access region of the human brain. Exosomes are powerful mediators that carry all the signalling and the machinery necessary to change the behaviour of a cell. As Hellobo explains, the line created by ReNeuron comes from its CTX technology and has been developed to carry the therapeutic proteins as well as delivering it to an exact destination - an area of the brain called the corpus striatum.
Este episodio se grabó el 23 de septiembre de 2021, en el estudio de radio de la Facultad de Ciencias de la Comunicación de la UMA. En esta ocasión excusaron su asistencia Francis (estaba en Naukas) y Belén. Como siempre, os presentamos una tertulia con la actualidad de la semana en investigación biomédica. Tras la presentación con las habituales efemérides del día, se inicia la tertulia. Silvana nos presenta el primer artículo: un trabajo del grupo de Kevin Morris (City of Hope-Beckman Research Institute, Duarte, USA) en el que se muestra una ingeniosa estrategia terapéutica contra el SIDA. Estos investigadores han modificado células en cultivo para que produzcan exosomas (vesiculas derivadas de la membrana celular) que transportan en su interior ARN condificante para una metil transferasa (DNMT3A) fusionada a una proteína de unión al DNA (ZFP-362). De esta manera, los autores han conseguido dirigir la actividad metilasa a una secuencia concreta del genoma del virus (LTR, reconocida por la ZFP-362) y silenciar la replicación del virus HIV-1 integrado en las células infectadas (la referencia es: Shrivastava et al. (2021). Exosome-mediated stable epigenetic repression of HIV-1. Nat Commun 12, 5541, https://doi.org/10.1038/s41467-021-25839-2). Íker nos trae las siguientes (bio)noticias que comenta junto con Silvana y Pepe: i) se ha anunciado un incremento en la dotación presupuestaria para las ayudas a actividades de divulgación científica gestionadas a través de la FECYT (Ayudas para el Fomento de la Cultura Científica, Tecnológica y de la Innovación); ii) un comentario en Nature se hace eco de un estudio publicado por el investigador Lokman Meho (la referencia es: Meho, L.I. (2021). The gender gap in highly prestigious international research awards, 2001–2020. Quantitative Sci Stud 1–14. https://doi.org/10.1162/qss_a_00148) en el que se indica que, aunque el número de grandes premios de investigación concedidos a mujeres está aumentando, aún es inferior al de hombres y no está en proporción con los puestos de liderazgo científico alcanzados por las mujeres; iii) celebración del Día Mundial del Alzheimer (21 de septiembre); y iv) un nuevo método de diagnóstico de tumores pancreáticos y/o de las vías biliares basado en la secuenciación masica del ADN presente en la bilis. Este importante y novedoso estudio ha sido coordinado por los doctores Matías Ávila y Carmen Berasain, del CIMA, en Pamplona (la referencia es: Arechederra et al. (2021). Next-generation sequencing of bile cell-free DNA for the early detection of patients with malignant biliary structures. Gut gutjnl-2021-325178, http://dx.doi.org/10.1136/gutjnl-2021-325178). Tras las (bio)noticias, finalizamos el episodio con un estudio en Drosophila que nos trae Pepe y la entrevista a la Investigadora Principal responsable del estudio: la Dra. Lola Martín-Bermudo, del Centro Andaluz de Biología del Desarrollo. Mediante screenings de RNAi y CRISPR en embriones de la mosca Drosophila, este grupo de investigación ha identificado un nuevo regulador negativo del oncogén Ras. Se trata de una proteína que interacciona con el receptor de EGF, razón por la cual, la han denominado EGFRAP (la referencia es: Beatty et al. (2021). EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis. Plos Genet 17, e1009738 https://doi.org/10.1371/journal.pgen.1009738). Como siempre, esperamos que este episodio os resulte interesante y entretenido. Bienvenidos y gracias por seguir ahí.
The Aspen Institute in Denver, Colorado provides the very latest non-surgical, stem cell, and exosome regenerative treatments to fight the effects of aging. Call 970-283-7797 to find out more. Go to https://aspen-regenerativemedicine.com (https://aspen-regenerativemedicine.com) for more information.
Key Takeaways: A little bit about Dr. Kaylea and how she found herself in medicine. Realizing food is so impactful towards our health and inflammation, Dr. Kaylea knew she had to show up differently for her unhealthy patients. Dr. Kaylea shares what her PLAN acronym stands for and why she uses it as a framework. Dr. Kaylea feels so grateful that she is in this line of work and able to help impact people's lives. The easiest way to inspire someone to lose weight is to have them see the last 10lb they lost. The progress is contagious. How does simulation in the spine work? How does regenerative medicine work and how does Dr. Kaylea guide her patients when it comes to stem cells? What are the different types of stem cells out there? Why does Dr. Kaylea favor exosome therapy? Exosome treatments do wonders to those suffering from COVID. How do peptides work for pain? When it comes to pain management, you have to look at the root problem. Which peptides does Dr. Kaylea prefer? What's some of the best ways to age gracefully? Dr. Kaylea shares her thoughts. Episode Summary: Dr. Kaylea Boutwell Lenarz is passionate about helping her patients live a pain-free life. She builds entirely customized and multi-faceted treatment plans for every patient, and shares her keys to success in this week's episode. You'll learn everything from the different types of stem cells out there, to why she loves peptides and exosomes. Guest Bio: Dr. Kaylea Boutwell Lenarz. Since the completion of her medical training and residency at Saint Louis University Hospital (2001 - 2008), and subsequent Specialty Fellowship at the world-renowned Cleveland Clinic Foundation Hospital, her practice has been devoted exclusively to top-tier Pain Management. It was in 2011, at only 32 years old, when she herself was taken entirely out of physical commission by an injury resulting in the rupture of two lower back discs. The journey back to a state of strength and physical predictability was arduous, but it imparted the blessing of an entirely new level of commitment and compassion for the patients who trust her with their care for pain in all it's places and forms. Resources for a Younger Lifestyle: Dr. Robyn Benson's Free Youthful Aging eGuide FREE GIFT: Robynbenson.com/gift Connect with Dr. Kaylea: Katalystmd.com Quotes: “A man with his health has a million dreams. A man without his health has but one.” “Pain doesn't have to be a way of life as you age.” “Surround yourself with people who want the same thing as you.”
ILLUMINATED ILLUSIONS PODCAST: A Virus is a solvent made in our cells | EXOSOME THEORY Visit Our Website: http://illuminated-illusions.com/livestream Join us on Rumble: https://rumble.com/account/content?type=all Donation: https://paypal.me/pools/c/8uJzowuzzv
What’s the most effective treatment for sexual performance we know of? How does it work? Is it safe? How successful is it, compared to other treatments? Today, The Novus Center answers all of your questions about the Stem Cell Exosome P-Shot. If you'd like to learn more about the Exosome P-Shot, we have more information on our website: https://www.thenovuscenter.com/treatments-los-angeles/sexual-performance/exosome-p-shot/ Studies on Stem Cell Exosomes and Sexual Performance: [CLINICAL STUDY] Stem Cell Therapy for Erectile Dysfunction: https://www.ncbi.nlm.nih.gov/pubmed/29631980 [CLINICAL STUDY] MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury: https://www.ncbi.nlm.nih.gov/pubmed/30257719 [CLINICAL STUDY] Embryonic stem cell-derived extracellular vesicle-mimetic nanovesicles rescue erectile function by enhancing penile neurovascular regeneration in the streptozotocin-induced diabetic mouse: https://www.nature.com/articles/s41598-019-54431-4#Sec10 FDA DISCLAIMER: THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE UNITED STATES FOOD AND DRUG ADMINISTRATION (FDA). EXOSOME THERAPY, STEM CELL THERAPY, SHOCKWAVE THERAPY, PRP THERAPY OR REGENERATIVE MEDICINE THERAPY IS NOT FDA APPROVED TO PREVENT, CURE OR TREAT DISEASES OR CONDITIONS. PLEASE VISIT THE FDA WEBSITE (WWW.FDA.GOV) FOR ADDITIONAL INFORMATION, INCLUDING CONSUMER ALERTS REGARDING EXOSOME THERAPY, STEM CELL THERAPY, SHOCKWAVE THERAPY, PRP THERAPY OR REGENERATIVE MEDICINE THERAPY. MEDICAL DISCLAIMER: These videos or any videos on "The Novus Center" YouTube channel does not provide medical advice. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this channel.
Dr. Richard Massey, MD Your Health Questions Answered Dr. Richard Massey joins us LIVE once a month to take health questions from our listeners. He is an MD practicing Wholistic and Natural Medicine docmassey@gmail.com Give Dr. Massey a call for a phone consultation 830-992-1143 Dr. Richard Massey talks about addiction and habitual patterns. “I just hate real estate,” complained one of Dr. Massey’s clients. Dr. Massey asked her, “What is our first home? The womb.” He explains how real estate and the womb tie together, using Recall Healing. “What happened at your birth?” is an important question to ask. “My burden in life gets lighter.” Saying it can make diseases go away. “Almost always there’s a family story,” regarding all diseases, including thyroid diseases. “Biology is like the accountant. It keeps track of everything,” says Dr. Massey. Patrick asks for more information about the thyroid and it’s relationship to time. Dr. Massey replies in detail. Patrick’s question leads to a discussion about synchronicity and the nature of “time.” Dr. Massey’s grandparents barely survived the “Great Miami hurricane” in 1926. His father became a weatherman. Diseases have two main causes — birth or family constellations. This coronavirus is not the problem. “Each person will find their part in it,” Dr. Massey explains. “My cells are actually ejaculating exosomes. Somehow the word ‘virus’ got put on these little particles of connection.” Virus has meant “poison” for 500 years, “Exosome” is a much better word. Dr. Massey didn’t wear a mask in the operating/recovery rooms, and he never caught anything. “When a doctor says, ‘Oh, my, there’s two small spots on the lung,’ we forget the several trillion that are functioning perfectly well.” Patrick discusses his sleeplessness. He speculates it’s about his compassion for what other people are experiencing (losing their businesses, etc.) “If I had any symptoms, I’d be staying home,” Dr. Massey says about the coronavirus, comparing his chances of survival at home versus a hospital, but it’s everyone’s choice, not personal advice. A listener asks Dr. Massey about testosterone. Dr. Massey personally takes a bio-identical version along with a little DHA and sometimes pregnenolone. A listener asks about rheumatoid arthritis. Dr. Massey talks about “telling the story so there are no victims or perpetrators,” then gives additional details about remedies that can make a difference. Patrick and Dr. Massey discuss pasteurization and “solution-mongers.” A listener has a “fluttering left ear.” Dr. Massey gives some practical advice.
Pain and discomfort keep us from being enthusiastic and energetic! God gave our bodies amazing restorative powers and by incorporating regenerative medicine we can ignite our body’s natural ability to heal itself. Regenerative medicine is a natural approach to activate our cells to repair tissues and organs to establish normal function. Wouldn’t it be better to regenerate and repair the body naturally instead of enduring surgery? Join Dr. Hotze and his guest Stephen Martinez today as they discuss Stem Cell Exosome therapy and how it helped Stephen recover from a running injury. After being treated with Stem Cell Exosome therapy, Stephen began to notice relief after a couple of weeks. The decrease in pain and increase in mobility continued to improve every week, and by month 3 life has greatly improved! Stephen Martinez, PA-C has a functional medicine practice in McAllen, Texas. He loves to listen to the guest stories. Stephen believes in creating an environment of independence, not dependence! Watch now and subscribe to our podcasts at www.HotzePodcast.com If you have any of the signs and symptoms mentioned on this podcast, take our free symptom checker test at https://www.hotzehwc.com/symptom-checker/ To contact Stephen Martinez @ Restore Wellness call him at (956) 683-6797 or visit online: www.RestoreRGV.com
Pain and discomfort keep us from being enthusiastic and energetic! God gave our bodies amazing restorative powers and by incorporating regenerative medicine we can ignite our body’s natural ability to heal itself. Regenerative medicine is a natural approach to activate our cells to repair tissues and organs to establish normal function. Wouldn’t it be better to regenerate and repair the body naturally instead of enduring surgery? Join Dr. Hotze and his guest Stephen Martinez today as they discuss Stem Cell Exosome therapy and how it helped Stephen recover from a running injury. After being treated with Stem Cell Exosome therapy, Stephen began to notice relief after a couple of weeks. The decrease in pain and increase in mobility continued to improve every week, and by month 3 life has greatly improved! Stephen Martinez, PA-C has a functional medicine practice in McAllen, Texas. He loves to listen to the guest stories. Stephen believes in creating an environment of independence, not dependence! Watch now and subscribe to our podcasts at www.HotzePodcast.com If you have any of the signs and symptoms mentioned on this podcast, take our free symptom checker test at https://www.hotzehwc.com/symptom-checker/ To contact Stephen Martinez @ Restore Wellness call him at (956) 683-6797 or visit online: www.RestoreRGV.com
There's a of talk out there that COVID-19 is actually an exosome. There's now also talk that all exosomes are bad. Is this really true? Austin Wolff breaks down these myths and sheds some light on a very complicated subject. Transform Your Body And Change Your Life With Biotech: https://www.ModernBiotechRadio.com Show Notes: Kurzgesagt - How The Coronavirus Works: https://youtu.be/BtN-goy9VOY
The truth about exosomes, i.e., what they really are and why they are in the bloodsteam and what they have to do with mycoplasma infectionsMusic by Twisterium licensed June 2019
What are exosomes? What can stem cell exosomes do for you? Find out how Stephanie is using stem cell exosomes in her clinic and how she can heal your joint pain, transform your sexual performance, and help repair your lungs! Also hear her personal story, and how she was able to defy the surgeon and heal her own fracture WITHOUT surgery. Even the X-ray technician couldn't see any history of a fracture in her X-ray! All of your questions are answered right here, right now...
This week, Doctor Tom goes over an Exosome Injection he had last year in July. After getting the injections he felt rejuvenated,filled with vigor, and thought he could lift a truck. Doctor Tom goes over such questions such as: What happens with a Exosome injection? Does Causenta off Exosome injections? What can Exosomes do? What can Exosomes repair? Dr. Tom (Thomas Incledon) is the founder and CEO of Causenta Wellness, and the Causenta Cancer Treatment Center in Scottsdale, Arizona. Doctor Tom's mission at Causenta is to "Kill cancer once and for all with minimal side effects". Join Doctor Tom and the team at Causenta as he answers important questions about cancer treatment and wellness.
Dr. Sierakowski earned both her BS in Biological Sciences and Doctor of Medicine from the University of Connecticut. She completed the Integrative Medicine in Residency during her Family Medicine training at the University of Arizona Alvernon, and is board certified in Family Medicine. She is Fellowship trained in Integrative Medicine through AzCIM and is pursuing Fellowship in Anti-Aging, Regenerative, and Functional Medicine through A4M, anticipating board certification in both Integrative and Functional medicines. She carries certificates in functional endocrinology, mitochondrial health, bioidentical hormone replacement therapy, and an array of integrative modalities. As physician and owner of Essential Health and Wellness, Dr. Elizabeth Sierakowski is committed to an atmosphere of warmth and the pursuit of excellence in primary care. These qualities help patients achieve whole and lasting wellness through optimization of the body and integration of the mind and spirit. She is a member of the American Academy of Family Practice and the American Academy of Anti-Aging and Regenerative Medicine. Professionally, her interests include preventive wellness care of children and adults, addressing exhaustion and burnout, and gut microbiome rehabilitation. She and her husband Jonathan enjoy traveling, adventures in the kitchen, and playing with their Goldendoodle pup Zelda.Links:Essential Health & Wellness PracticeInstagramA4M Provider search for Anti-Aging MedicineBooks:Crossing the unknown seaThe Circadian CodeWhat the heck should I eat?Women who run with the WolvesBraving the Wilderness by Brené Brown
Exosomes, what are they and why do they exist? Well, if you haven’t heard what exosomes are, then you are not alone. Exosomes are extracellular vesicles first discovered 30 years ago. It was since implicated in cell-cell communication and the transmission of disease states. It was also explored as a means of drug discovery. So how are these extracellular vesicles important? Exosome therapies are now being explored in anti-cancer clinical trials, and recent reports claim taxol-filled exosomes can be used to treat cancers in mice at 50-fold lower doses than conventional treatments. And that is with the additional benefit that exosomes do not invoke an immune response. To explain more about exosomes, Jim West visits the Startup Hustle studio. West is a life science entrepreneur, founder, and engineer. He is the founder of Clara Biotech, Anatomy3D, and Somametric. At Clara Biotech, their mission is to enable therapeutic and diagnostic discovery and support clinical applications by providing the tools researchers need to harness the full potential of exosomes. The company was founded by scientists in 2015 who have spent much of their professional careers contending with the trials and tribulations of exosome research. Clara Biotech is a platform technology that allows for the isolation of specific cellular markers (exosomes) from very small fluid samples, enabling liquid biopsy for the very early detection of cancer, Alzheimer's Disease, and many others. These same markers can also be turned into a precision medicine drug delivery platform delivering targeted drugs directly to the cells being targeted. Learn more about: Full Scale: https://fullscale.io/ Stackify: https://stackify.com/ Clara Biotech https://www.clarabio.tech/ GigaBook: https://gigabook.com Follow us on Instagram: https://www.instagram.com/startuphustlepodcast/ Subscribe to our YouTube channel: https://www.youtube.com/channel/UCDXy14X95mzCpGSHyDvvoVg Follow us on TikTok: https://www.tiktok.com/@startuphustle
Host Kevin Patton summarizes many strategies from learning science that can amplify learning in our courses. Also, updates in the role of exosomes in the spread of cancer and how activity type affects the shape of our heart. 00:48 | Jargon: Show Notes & Episode Pages 05:07 | Sponsored by HAPS 07:01 | Role of Exosomes in Spread of Cancer 13:20 | Sponsored by AAA 13:44 | Activity Type Affects Heart Shape 18:03 | Sponsored by HAPI Online Graduate Program 18:35 | Amplifying Learning in A&P: ANSWER 53:30 | Staying Connected If you cannot see or activate the audio player click here. Questions & Feedback: 1-833-LION-DEN (1-833-546-6336) Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! Give the pupils something to do, not something to learn; and the doing is of such a nature as to demand thinking; learning naturally results. (John Dewey) 1 | Jargon: Show Notes & Episode Page 4 minutes Kevin explains that show notes are notes and links related to an episode. You are reading the show notes right now! The episode page is a page dedicated to an episode at theAPprofessor.org and it contains the show notes, which may also be available in the podcasts or radio app where you listen to episodes. 2 | Sponsored by HAPS 2 minutes The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast. You can help appreciate their support by clicking the link below and checking out the many resources and benefits found there. There are a bunch of 1-day regional workshops scattered all over the continent. There's probably one near you coming up this year (or next)! Cleaning Anatomical Models with Denture Tablets (blog post by Carol Britson) my-ap.us/2Qn9FnP Anatomy & Physiology Society theAPprofessor.org/haps 3 | Exosomes & Metastasis 6.5 minutes Extracellular vesicles (EVs) such as exosomes and oncosomes play important roles in spreading cancer. For example, exosomes play a role in the metastasis of breast and lung cancer, through the blood-brain barrier (BBB) to the brain tissue. We are still working out the mechanisms. Sneaky Spread: How breast cancer uses exosomes to breach the blood-brain barrier (news summary) my-ap.us/2QjS5Rw Brainwashed by extracellular vesicles: the role of extracellular vesicles in primary and metastatic brain tumour microenvironment (review article) my-ap.us/2QkDoxv What are Oncosomes? (description) my-ap.us/2Qj3PUf 4 | Sponsored by AAA 0.5 minutes A searchable transcript for this episode, as well as the captioned audiogram of this episode, are sponsored by the American Association for Anatomy (AAA) at anatomy.org. Searchable transcript Captioned audiogram 5 | Activity & Heart Shape 4.5 minutes Evolution has played a role in making human hearts similar to chimpanzee hearts. The left ventricle is thick-walled and short—best suited for shorter and perhaps intense bursts of activity. However, the heart is able to elongate and have a thinner wall to adapt to a lifestyle that features endurance activity. Running—or sitting—can change the shape of your heart (news summary) my-ap.us/2ACm7oO Selection of endurance capabilities and the trade-off between pressure and volume in the evolution of the human heart (research article) my-ap.us/2AEbvpO " the human (LV) evolved numerous features that help to augment stroke volume (SV), enabling moderate-intensity EPA. We also show that phenotypic plasticity of the human LV trades off pressure adaptations for volume capabilities, becoming more similar to a chimpanzee-like heart in response to physical inactivity or chronic pressure loading." 6 | Sponsored by HAPI Online Graduate Program 1 minute The Master of Science in Human Anatomy & Physiology Instruction—the MS-HAPI—is a graduate program for A&P teachers. A combination of science courses (enough to qualify you to teach at the college level) and courses in contemporary instructional practice, this program helps you power up your teaching. Kevin Patton is a faculty member in this program. Check it out! nycc.edu/hapi 7 | Amplifying Learning in A&P 35 minutes In this discussion, Kevin borrows a mnemonic acronym from Yee and Boyd (cited below) that summarizes key strategies derived from learning science (cognitive psychology) and riffs on adapting it to the A&P course to amplify learning. How Can We Amplify Student Learning? The ANSWER from Cognitive Psychology (article from Faculty Focus) my-ap.us/2AEaIoQ Measuring actual learning versus feeling of learning in response to being actively engaged in the classroom (research article) my-ap.us/2AEUWd6 There's Been A Misunderstanding (opinion piece on what we mean by "lecture") my-ap.us/2AzHMyb The Distracting Draw Of Smartphones (episode of Hidden Brain podcast) my-ap.us/2AFZ6kU Some of the episodes mentioned in this segment Playful & Serious Is the Perfect Combo for A&P | Episode 13 Storytelling is the Heart of Teaching A&P | Episode 12 The Wallenda Model of Homeostasis | Episode 46 Fishbowl Model of Homeostasis | Concept Lists | TAPP Identity | Episode 45 Spaced Retrieval Practice | Episode 1 Cumulative Testing Makes Learning Last | Episode 4 Running Concept Lists Help Students Make Connections | Episode 8 The Case for Transparency | Episode 51 If the hyperlinks here are not active, go to TAPPradio.org to find the episode page. More details at the episode page. Transcript available at the script page. Listen to any episode on your Alexa device. Need help accessing resources locked behind a paywall? Check out this advice from Episode 32 to get what you need! https://youtu.be/JU_l76JGwVw?t=440 Sponsors Transcript and captions for this episode are supported by the American Association for Anatomy. anatomy.org The Human Anatomy & Physiology Society also provides marketing support for this podcast. theAPprofessor.org/haps Distribution of this episode is supported by NYCC's online graduate program in Human Anatomy & Physiology Instruction (HAPI) nycc.edu/hapi Clicking on sponsor links helps let them know you appreciate their support of this podcast! Referrals also help defray podcasting expenses. Amazon TextExpander Snagit & Camtasia The A&P Professor Logo Items Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton)
A brief preview of the upcoming full episode 53, featuring upcoming topics that include tips for amplifying learning in the A&P course, updates regarding the role of exosomes in the spread of cancer and how heart shape relates to human activity. There's more... some word dissections and Kevin's recommendation for The A&P Professor Book Club. If you cannot see or activate the audio player click here. Questions & Feedback: 1-833-LION-DEN (1-833-546-6336) Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! Topics 1 minute Strategies to amplify learning in the A&P course The role of exosomes in the spread of cancer How heart shape relates to type of activity Word Dissections 8.5 minutes Metastasis Extracellular vesicle (EV) Exosome Oncosome Transcytosis Book Club 3.5 minutes Prime Mover: A Natural History of Muscle by Steve Vogel amzn.to/30jcKcm Special opportunity Contribute YOUR book recommendation for A&P teachers! First five submitted and used will be in a drawing for a Kindle Fire HD 10 tablet amzn.to/2WwLZvb Any contribution used will receive a $25 gift certificate The best contribution is one that you have recorded in your own voice (or in a voicemail at 1-833-LION-DEN) Check out The A&P Professor Book Club If the hyperlinks here are not active, go to TAPPradio.org to find the episode page. More details at the episode page. Transcript available at the script page. Listen to any episode on your Alexa device. Need help accessing resources locked behind a paywall? Check out this advice from Episode 32 to get what you need! https://youtu.be/JU_l76JGwVw?t=440 Sponsors Transcript and captions for this episode are supported by the American Association for Anatomy. anatomy.org The Human Anatomy & Physiology Society also provides marketing support for this podcast. theAPprofessor.org/haps Distribution of this episode is supported by NYCC's online graduate program in Human Anatomy & Physiology Instruction (HAPI) nycc.edu/hapi Clicking on sponsor links helps let them know you appreciate their support of this podcast! Referrals also help defray podcasting expenses. Amazon TextExpander Snagit & Camtasia The A&P Professor Logo Items Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton)
New report shows serious health problems with vaping; m: E-Cigarette flavorings interacts with solvents to create dangerous chemicals; Arginine vasopressin helps administering blood in trauma patients -- gun issues discussed; C. difficile infection can be aided by other cooperative bacteria and fungi; The interesting idea of using ammonia-eating bacteria instead of bathing! Anti-inflammatory agents and common drugs encourage bacteria to share antibiotic resistance genes; Communication between mother and fetus through proteins in exosomes; Pomegranate juice helps with slow growth problems in utero; Brain biofeedback can reduce Tourette syndrome symptoms as shown by fMRI; A exciting use of EEG to diagnose autism at an early stage; New biochemical details about the toxoplasmosis and cat interaction story
Stephanie Wolff, P.A.-C and CEO of Novus, gets Exosomes and explains how they can help your joint pain, skin, hair, and even sexual performance. (KEEP READING...) EXOSOMES VS STEM CELLS: https://www.thenovuscenter.com/exosom... EXOSOMES FOR HAIR GROWTH: https://www.thenovuscenter.com/hair-g... EXOSOMES FOR SEXUAL PERFORMANCE (Exo P-Shot): https://www.thenovuscenter.com/exosom...
Want to reach the NEXT LEVEL in sexual performance? Want to be the best partner they’ll ever have in their entire life? This isn’t some gas-station pill… This is the next stage in human biotech. Safer, more efficient, and MORE EFFECTIVE THAN STEM CELLS… EXOSOMES. What are they? Exosomes are essentially the “workers” of stem cells. They do the work. They run the show. And now they can transform your sexual performance more than shockwave, PRP, or stem cells ever could… If you want the FERRARI of sexual performance… If you want your “package” to be the “McLaren of packages…” Click below to schedule a call with my Exosome Specialist. https://www.thenovuscenter.com/exosom… For more information check us out: TWITTER: https://twitter.com/NovusCenters FACEBOOK: https://www.facebook.com/novus.centers/ INSTAGRAM: https://www.instagram.com/novus.centers/ YOUTUBE: https://www.youtube.com/channel/UCbspWZlciV6cLZIlv7Mjw_A/videos
Exosomes isolated from cerebrospinal fluid were rich in proteins originated from the brain
Lyme Voice Radio, Discussing your Lyme Disease Journey with Aaron & Sarah Sanchez
In this episode, Aaron and Sarah talk about the primary treatments used at Envita Medical for treating neurological Lyme disease. Sarah went to treatment in 2013 for late-stage neurological Lyme disease and Envita saved her life. After being reinfected in 2018 she returned and did a second round of treatment in 2019. Segment 1 FIGHTING is a mindset! ~Patient Care Coordinators are a vital link between you and all your physicians. They keep tabs on you throughout your entire visit, make sure you are getting to your outside appointments. So many times throughout my years of battling chronic Lyme I would wish that someone could be in charge of me, give me advice, or help me make decisions, that is what the Patient Care Coordinators do for you, it is fantastic. Click here to see more https://www.envita.com/about ~NMD's-Naturopathic Medical Doctor (integrative) Most of the physicians at Envita are Naturopathic Medical Doctors which is my favorite type of physician because they problem-solve with a wide variety of natural modalities. ~PTSD-I definitely battled PTSD while out at treatment for the 2nd time. It was prepared for the reality that I was leaving my family for 10 weeks and would be living in a hotel. I was even prepared for the intense Mon-Fri treatment schedule, but the emotional weight of being back at treatment, having my life once again be put on hold was and still is immense. I'm honestly still trying to figure it out. Segment 2-HEALING always consists of choices ~Housing while at Envita Medical If you fully implement all the protocols (outside) then you should in some way be prepared for it to be all-encompassing...and yet totally boring at the same time ~Ozone therapy ~Bemer PEMF Mat ~Hydrogen Peroxide IV-is an antiviral therapy that is especially helpful for Lyme patients due to co-viral infections. Envita uses a unique formula that is able to pass through the blood-brain barrier ~DMPS Chelation removes heavy metals from the body. Improves your ability to fight infection ~Glutathione push -IRAD is the neurological repair program that completely changed my life back in 2013. This time it didn't disappoint, after the 4th treatment I just felt like I could think on another level, I had a more executive function. The possible benefits of IRAD can be: Deeper delivery of the antibiotics Penetration into the central nervous system via insulin Helps infections that impact the nervous system Detoxifies the liver Immune Modulator Potentiates the antibiotics to kill the infection For more info on treating late-stage neurological Lyme disease or Lyme disease complex, https://www.envita.com/conditions/lyme-disease ~Ketamine can help with resetting the neurological system, wiping it clean so that the synapsis connections can connect properly, it can be helpful with tremors, insomnia, depression, addiction. ARTICLE LINKS Ketamine for chronic pain: risks and benefits Effects of intravenous ketamine in a patient with post-treatment Lyme disease syndrome ~Exosome treatment-Exosomes are a subtype of membrane vesicle released from the endocytic compartment of live cells. They play an important role in endogenous cell-to-cell communication. Previously shown to be capable of traversing biological barriers and to naturally transport functional nucleic acids between cells, they potentially represent a novel and exciting drug delivery vehicle for the field of gene therapy. Existing delivery vehicles are limited by concerns regarding their safety, toxicity, and efficacy. In contrast, exosomes, as a natural cell-derived nanocarrier, are immunologically inert if purified from a compatible cell source and possess an intrinsic ability to cross biological barriers. Already utilized in a number of clinical trials, exosomes appear to be well-tolerated, even following repeat administration ARTICLE LINKS Exosomes and the Emerging Field of Exosome-Based Gene Therapy Segment 3-LIVE ~Environment is HUGE ~Support system is HUGE (if you don't have this, if you are surrounded by toxic people who can't or won't support you, find new people, start there) This is not your fault but it is your responsibility. Links Kangen Water- http://www.lymewater.com/ Envita Medical –Envita Medical Lyme Voice Facebook The Lyme Voice Podcast- Lymevoice.com Lyme Documentary-Disappearing From Society, Life with chronic Lyme in 14 minutes…Documentary Little Bite, BIG TROUBLE, available on Amazon –Children’s book about Lyme disease
For over a century, conventional science has attributed illness and disease to mechanistic failures of the body's systems. Rather than “victims” of dysfunctional cells and genes, the new fields of epigenetics and quantum biophysics reveal that your mind expresses creative mastery over your biology and the character of your life. A radical new insight on how the mind shapes the body was discovered in 2007. A population of exosomes, small submicroscopic vesicles in the blood, were found to be virus particles created by our own cells and designed to infect our own cells. Via the cell's membrane, consciousness is translated into gene and behavior controlling molecules. These information molecules can be conveyed by exosome viruses to specifically targeted cells. Exosome signaling coordinates the structure and function of the body's cellular community in shaping overall health and wellbeing, including disease states, especially cancer. Understanding epigenetic and exosome mechanisms offers profound insight on the process of expressing self-empowerment in the unfolding of our lives. Join Bruce H. Lipton for an illustrated and animated presentation that will engage your mind and challenge your creativity as you comprehend the enormous potential for applying this information in your life and practice. MLF ORGANIZER NAME Adrea Brier NOTES MLF: Health & Medicine Learn more about your ad choices. Visit megaphone.fm/adchoices
The TWiM-opods consider two stories about exosomes, vesicles that are shed from cells: those that eliminate airway pathogens, and those from the plants we eat that shape our gut microbiome. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM. Links for this episode Exosome swarms eliminate airway pathogens (J Aller Clin Immunol) Exosome release from Bacteria, Eukaryotes, Archaea (Infect Immun) Plant exosomes shape gut microbiome (Cell Host Microbe) Image credit Subscribe to MicrobeTV on YouTube TWiM Listener survey Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses. Host: Vincent Racaniello Guests: Nicholas Buchkovich and Leslie Parent Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode HIV-1 gag membrane binding domain (J Virol) Nuclear experience for gag (PNAS) Gag in nucleolus (J Virol) YB-1 for retrovirus assembly (J Virol) HCMV controls BiP levels (J Virol) HCMV regulates La (J Virol) Inhibition of HCMV by modulating syntaxin 5 (J Virol) Non-envelopment role for ESCRT-III during HCMV infection (J Virol) Late retroviral budding function (J Virol) Grit by Angela Duckworth The Scientists by John Gribbin Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
What you are about to discover in this podcast is one of the most advanced, fringe, cutting-edge biohacks and forays into self-experimentation I've ever done... ...a full body stem-cell makeover at in Salt Lake City, Utah...including a little-known type of compound called an "exosome". Dr. Harry Adelson, my first guest on today's podcast, began his training in regenerative injection therapy (prolotherapy) in 1998 while in his final year at The National College of Naturopathic Medicine, in Portland, Oregon after having been cured of a rock-climbing injury with prolotherapy. During his residency program in Integrative Medicine at the Yale/Griffin Hospital in Derby, Connecticut, he volunteered after hours in a large homeless shelter in Bridgeport, Connecticut, providing regenerative injection therapies to the medically underserved while gaining valuable experience. He opened Docere Clinics in Salt Lake City in 2002 and from day one, his practice has been 100% regenerative injection therapies for the treatment of musculoskeletal pain conditions. In 2006 he incorporated platelet-rich plasma and ultrasound-guided injection into his armamentarium, in 2010, bone marrow aspirate concentrate and adipose-derived stem cells, and in 2013, fluoroscopic-guided injection (motion X-ray). Since February of 2010, Dr. Adelson has performed over 4,000 bone marrow and adipose-derived adult stem cell procedures, placing him among those most experienced in the world with the use of autologous stem cells for the treatment of musculoskeletal pain conditions. Dr. Amy Killen is also a guest on today's show. She joined Docere Medical after moving to Utah from Portland, Oregon, where she was the Medical Director of an anti-aging and regenerative medicine specialty practice. Dr. Killen’s medical training began in Dallas, where she attended medical school at UT Southwestern and received her M.D. degree, graduating in the top 10% of her class. She completed a residency in Emergency Medicine at the University of Arizona and served as Chief Resident during her final year. After working as a board-certified emergency physician for more than 7 years, Dr. Killen began studying and training in anti-aging, regenerative, and aesthetic medicine in hopes of approaching patients’ wellness and beauty from a different perspective and with a new toolbox of innovative and effective treatment options. Advanced training has included completion of the fellowship in Anti-Aging and Regenerative Medicine through the American Association of Anti-Aging Medicine and certification training in Age Management Medicine. Dr. Killen is certified by the National Institute of Medical Aesthetics in both basic and advanced cosmetic injections and trained with Dr. Lisbeth Roy to learn the O-Shot and P-Shot PRP procedures. Further PRP injection training was provided by PRP Life Lift and she completed the Hair Coach certification program with Dr. Alan Bauman in Florida, which taught a comprehensive approach to non-surgical hair loss. Dr. Killen learned how to extract and process stem cells as part of the U.S. Stem Cell Training Course taught by leading stem cell scientist Dr. Kristin Comella. Dr. Amy Killen has also spent many hours in the operating suite learning directly from Harry Adelson N.D. at Docere Clinics. Dr. Killen has spoken nationally about PRP and stem cell therapies and teaches a physician training course for ApexBiologix outlining current best practices for using regenerative therapies in aesthetics and sexual optimization. During my discussion with Harry and Amy, you'll discover: -How Harry got started with prolotherapy and PRP for pain management in farmers and construction workers... -The “Stem Cell Theory of Aging", which states that biologic aging is a result of loss function and population of stem cells in musculoskeletal tissues... -How Harry is harvesting stem cells from bone marrow, supplementing them with exosomes (the “currency” of stem cells, the inter-cellular communication blocks), and then injecting them into all major moving parts as well as skin of face, scalp, and penis... -Why exosomes may be the future of stem cell therapy... -Why umbilical and amniotic stem cells could potentially be dangerous due to exposing the body to foreign DNA... -What "MSC's" are, why are they different and better than other stem cell therapies, and how they differentiate into musculoskeletal tissues and have been called “medical signaling cells” because they trigger the healing of damaged tissues... -Why somebody would undergo a full body stem cell treatment, and whether is it going to "rejuvenate all of the cells in my body"... -What to expect after a full body stem cell makeover... Interview with Dr. Amy Killen: -What PRP therapy is, and how it differs from stem cells... -What happens when you inject stem cells into a man’s "unit", and why Amy injected Ben... -Why Amy injects stem cells and PRP into vaginas, and how the O-Shot improves the power and duration of female orgasms... -The secrets of the vampire breast lift and other cosmetic procedures she has done... -What causes hair loss, and how to fix it with stem cells... -How to use stem cells and PRP to get a non-surgical facelift, and why Amy injected my face and scalp... -What V-cells are and how they work... -Post-treatment care and biohacks to enhance recovery and efficacy of the treatment... -And much more! Resources from this episode: - -Video: -Video: -Video: -Video: -All the recovery biohacks I implemented to recover from the stem cell procedures and enhance stem cell production: - - - - - - - - - - - Episode Sponsors - Join me for an amazing week at Runga. It's one of the most amazing weeks of my year. Use discount code "ben" to secure the one last minute reservation that just became available. - Support for normal blood sugar levels and healthy energy metabolism, even after large, carb-rich meals. - Get 15% off your order when you use my link and get a couple of travel packs on the house if you sign up for a subscription. - Next-Level Light Therapy. See how Joovv can help you reach—and surpass—your health and fitness goals. - Engineered for peak performance, Onnit is the easiest way to get optimized. Do you have questions, thoughts or feedback for Dr. Harry, Amy or me? Leave your comments below and one of us will reply!
Peter H Backx, PhD is a senior scientist at Toronto General Hospital Research Institute and also at York University. Dr Backx is a recognised expert in cardiac mechanics, heart failure and arrhythmias. His research focuses on the role of ion transport, ion channels and myocardial signalling in the initiation and progression of heart disease with a particular interest in atrial fibrillation. He holds a patent on tissue-specific drug delivery and has published over 190 peer-reviewed articles, many in the top tier journals like Cell, Nature, Nature Medicine, Journal of Clinical Investigation and Circulation Research. His work has been cited over 12,900 times, with over 5600 in the last 5 years. Dr Backx has delivered over 150 distinguished invited lectures at the national and international level. You could listen to this podcast to learn more about the causes of arrhythmias in endurance athletes. Special thanks to Mark Featherman for the introduction to Dr Backx and also some excellent questions. Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following: One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up. One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why. One remarkable thing that we think you’ll enjoy! Here’s the outline with Peter H Backx, PhD: [00:00:06] Book: The Haywire Heart: How too much exercise can kill you, and what you can do to protect your heart. [00:00:21] PHAT FIBRE MCT oil powder. [00:01:27] Toronto General Hospital Research Institute (TGHRI). [00:01:50] Atrial arrhythmias. [00:03:23] The electrical system of the heart. [00:04:04] SA node. [00:07:30] Main symptoms: fatigue, dizziness. [00:09:02] Peter is trained as a cardiac electrophysiologist. [00:09:18] Sudden cardiac death. [00:09:43] Ventricular tachycardia. [00:10:23] The dangers of afib. [00:11:03] Paroxysmal (acute) afib. [00:12:07] Tommy and Mark Cucuzzella podcast: greatest risk endurance athletes doing more than an hour per day for 20 years. [00:13:01] Biggest risk factor is ageing. [00:13:36] CVD risk factors are also predictive of afib. [00:14:39] Is there a threshold? [00:15:25] Athletes may be at great risk for vfib. [00:17:30] Genetic predisposition. [00:18:33] Exosome (genetic) testing. [00:19:15] Ion channels. [00:20:17] Ablation. [00:22:24] Mark Featherman, you rock! [00:22:55] If you continue doing the same thing, will you develop another arrhythmia? [00:24:44] Finding the sweet spot of exercise. [00:25:36] Exercise intensity. [00:26:20] Polarised training. See Hydren, Jay R., and Bruce S. Cohen. "Current scientific evidence for a polarized cardiovascular endurance training model." The Journal of Strength & Conditioning Research 29.12 (2015): 3523-3530. [00:27:00] Rodent studies. [00:28:18] Only the mice running on weighted wheels developed pathological changes. [00:32:13] Chronic inflammation. [00:32:41] Rheumatoid arthritis. [00:34:05] TNF-a is a mechanosensor. [00:34:58] TNF-a inhibitors. [00:35:51] Etanercept. [00:36:09] XPro®1595. [00:37:02] Blood testing for TNF-a. [00:37:41] Kroetsch, Jeffrey T., et al. "Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure." Nature Communications 8 (2017). [00:39:01] Sebastian Bolz, PhD. See Hui, Sonya, et al. "Sphingosine-1-phosphate signaling regulates myogenic responsiveness in human resistance arteries." PloS one 10.9 (2015): e0138142. [00:41:11] The atria as an endocrine organ, see atrial natriuretic factor. [00:42:36] Stretching the atria. [00:42:46] Alcohol. [00:43:54] Increased parasympathetic activity. [00:45:43] Low-dose alcohol is a stimulant, at higher doses, it's a depressant. [00:47:31] Caffeine. [00:50:12] Acid reflux. [00:50:37] Vagus nerve. [00:51:54] A hiatal hernia. [00:52:37] Proton pump inhibitors and dementia. [00:53:21] The 2016 Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi for his discoveries of mechanisms for autophagy. [00:53:54] Lysosomes. [00:55:03] The vulnerability period increases the chances of a “false start”. [00:58:18] Vagus nerve releases acetylcholine. [01:00:34] Are ablation procedures overperformed? [01:01:14] Stroke. [01:03:16] Increased back pressure “volume overload” models. [01:05:03] Heart & Stroke/Richard Lewar Centre of Excellence. [01:05:39] York University, Canada. [01:05:56] MRI on cyclists. [01:06:39] PubMed author search for Peter H. Backx. [01:07:34] Developing methods for producing atrial cardiomyocytes from stem cells.
Takahiro Ochiya explains how bone marrow mesenchymal stem cells can cause metastatic breast cancer cells to become dormant.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich and Kathy review how human placental trophoblasts confer viral resistance via exosome-mediated delivery of microRNAs, and isolation of the first human influenza virus in 1933. Links for this episode: Human placental trophoblasts confer viral resistance (PNAS) Placental circulation (Wikipedia) Ovum in uterine decidua (Wikipedia) A virus obtained from influenza patients (Lancet) 80 years ago today (the guardian) Influenza: Exposing the true killer (J Exp Med) Letters read on TWiV 239 Weekly Science Picks Matt - The Kid Should See ThisAlan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)Rich - Sydney Brenner (Web of Stories) Listener Pick of the Week Joe - Grand challenges in science education (Science)Mark - Weather Underground Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Carolyn Coyne, and Sara Sawyer Vincent, Rich, Carolyn, and Sara recorded TWiV at the 31st Annual Meeting of the American Society for Virology in Madison, where they discussed genetic conflict between viral and human genes, and how the placenta protects the fetus against viral infection. Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: ASV 2012 at Madison, WI Photographs of ASV 2012 Rock band Herpetic Legion plays at ASV 2012 TWiV on Facebook Letters read on TWiV 193 Weekly Science Picks Rich - Benjamin Franklin: An American Life by Walter IsaacsonVincent - Biochemistry Revealed Listener Pick of the Week Matlock - The BioDigital HumanMatt - Scientists create jellyfish from rat cells Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
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