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Dr. Hoffman continues his conversation with pioneering integrative medicine practitioner Dr. Jacob Teibelbaum.
Dr. Jacob Teitelbaum, integrative medicine physician, researcher, and best-selling author, details preventive measures and treatments for cognitive decline, including dementia and Alzheimer's disease. He covers a wide range of topics, including the impact of conventional medications, natural supplement alternatives, dietary interventions, the role of exercise, and the importance of addressing underlying health issues like thyroid problems and metabolic syndrome. Dr. Teitelbaum emphasizes practical and low-cost approaches, and he offers listeners detailed resources and guidance.
***JOIN THE NEXT MASTER YOUR FASTING CHALLENGE THAT STARTS August 13th, 2025!*** We'll GUIDE you on how to FAST to LOSE FAT for good, and use ‘fast cycling' to achieve uncommon results! REGISTER HERE! Click the link for DATES, DETAILS, and FAQs! This episode reveals shocking research from the Journal of Nature Metabolism showing why restarting your fasting routine after vacation or weekend indulgences feels impossibly difficult - and it's not your fault. Dr. Scott and Tommy break down a groundbreaking study demonstrating that just 5 days of eating an extra 1,100 calories (equivalent to 4 drinks or one extra meal plus dessert) creates lasting brain changes that persist for weeks, making fasting adherence incredibly challenging. Discover how short-term overeating disrupts brain insulin sensitivity, reduces reward sensitivity (making fasting victories feel less motivating), increases punishment sensitivity (amplifying guilt when you break fasts), and impairs memory consolidation so you can't remember your fasting successes. Learn why your brain adapts to caloric overload faster than your body shows weight gain, creating a neurological "lag effect" that sabotages your fasting motivation and willpower. The hosts provide practical fasting recovery strategies, including why you should expect the same recovery time as your time "off track," how to use strategic 24-36 hour fasts to reset brain-derived neurotrophic factor (BDNF) and restore normal hunger cues, and why you shouldn't immediately return to long extended fasts as "punishment." This episode reframes fasting setbacks as normal biology rather than moral failure, teaching you to anticipate and work with your brain's adaptation rather than fighting against it. Essential listening for anyone struggling with the summer vacation fasting cycle, weekend warrior mentality, or the frustrating pattern of breaking their fasting routine and struggling to get back on track. Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting! Resources and Downloads: SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS! SLEEP GUIDE DIRECT DOWNLOAD DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE! Partner Links: Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here! Get 25% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here! Our Community: Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://pmc.ncbi.nlm.nih.gov/articles/PMC11946887/pdf/42255_2025_Article_1226.pdf
Natural alternatives for Trump's chronic leg swelling problems; How certain blood and urine tests can help predict osteoporosis; Dark chocolate enhances cognitive function—with lasting effects; caffeinated black coffee reduces risk of death by 14%; NY Times misses the boat again on supplements for immunity; Man dies after being pulled into MRI machine.
Episode Summary: In recognition of World Brain Day (July 22), this Think Thursday episode is a deep dive into the powerful, daily practices that shape your brain's future. While most of us worry about cognitive decline, far fewer realize how much influence we actually have. Molly introduces SHARP—a simple, science-backed framework for protecting and enhancing your brain's longevity, clarity, and resilience. From reducing dementia risk to boosting neuroplasticity, this episode gives you the tools to keep your mind vibrant for years to come.What You'll Learn – The SHARP Framework:S – Sleep & Stress Regulation: Sleep is when your brain clears out toxins linked to Alzheimer's. Chronic stress, meanwhile, shrinks memory-related regions and floods your system with cortisol. Molly shares realistic strategies to optimize both sleep and stress management.H – Health Management: Hypertension, diabetes, and high cholesterol aren't just heart issues—they directly impair blood flow to your brain. Molly encourages listeners to know their health metrics and embrace preventive care, not just reactive treatment.A – Activity (Physical & Cognitive): Regular movement and mental challenge increase BDNF and hippocampal volume—both key for memory and learning. Learn how to find the right mix of cardio, strength, and cognitive novelty to protect your brain.R – Relationships & Recovery: Human connection is vital for long-term brain health. So is purposeful mental rest. Molly outlines ways to build deeper relationships while incorporating daily mental “micro-rests” to reset your attention and creativity.P – Plant-Forward Nutrition & Preventive Living: Diets like MIND and Mediterranean are clinically linked to younger brain age. Molly explains how building meals around plants, healthy fats, and fiber—while minimizing alcohol and ultra-processed foods—can provide neuroprotective benefits.Mini Challenge: Pick just one area of the SHARP framework to focus on this week. Your brain will thank you—and it will reward you with energy, clarity, and peace of mind.Resources & Mentions:Mel Robbins Podcast featuring Dr. Vonda WrightOfficial MIND Diet WebsiteStay Connected:Website: www.mollywatts.comJoin the Facebook Community: Alcohol Minimalists – Change Your Alcohol HabitsInstagram: @alcoholminimalist ★ Support this podcast ★
Send us a textOur physical body is a miracle, but our brain is even more amazing. In this episode, I share 5 proven ways to improve our brain, ways that we can all use to take better care of our control center. __________________________Do you have questions or comments?Please contact me: rtosguthorpe@gmail.comWant more info about my books and talks?Go to my website: https://www.russelltosguthorpe.com/Want to order a book? Just go to Amazon and type in Russell T. Osguthorpe Want to access my YouTube channel:https://youtube.com/@russellt.osguthorpe497Want know more about the music on this podcast? We are blessed to have M. Diego Gonzalez as a regular contributor of songs he has arranged, performed, and recorded especially for this podcast. My wife and I became acquainted with Diego when he was serving a as missionary in the Puerto Rico San Juan Mission. We were so impressed with his talent, we asked if he would compose and perform songs for Filled With His Love. He thankfully agreed. Hope you enjoy his work!Want to boost your mood and make someone's day?Go to the App store on your iPhone, and download the app—Boonto.Want a good introduction to my book? Morgan Jones Pearson interviewed me on the All-In Podcast, and it was one of the top 10 episodes of 2022. Here's the link:https://www.ldsliving.com/2022-in-review-top-10-all-in-podcast-episod...
What does it really take to age strong—and keep your brain sharp while you're at it?In this episode, I'm joined by Janet McConnell, a 69-year-old powerhouse who's redefining what it means to thrive into your 60s and beyond. A longevity coach, personal trainer, and former corporate high-flyer turned bodybuilding competitor, Janet shares her journey from a shocking doctor's visit at 46 to standing on a bodybuilding stage—and discovering the secrets of healthy aging along the way.We dive into topics like:Why resistance training is crucial for brain health and longevityHow lifting weights produces brain-derived neurotrophic factor (BDNF) and protects cognitive functionCommon myths keeping women (especially over 40) out of the weight room—and how to overcome themJanet's incredible personal transformation and lessons learned from stepping on stage at age 48How to safely get started with resistance training at any ageTips for finding the right trainer or fitness community (and how to spot red flags)Why training for life—not just aesthetics—is the key to long-term health and independenceThe real reason obstacles show up when you're making changes—and how to handle themJanet's message is clear: You're never too old—and it's never too late—to build a strong body and mind. Whether you're in your 30s, 40s, 50s, or pushing 70, this episode will inspire you to take up space and take charge of your health.Connect with Janet McConnell:YouTube: Aging Strong For LifeLinkedIn: Janet McConnellBook: Elements of AgingWebsite: ignitefitnesswithjanet.comEmail: janet.mcconnell@gmail.comConnect with Coach Diana LeighIG, TikTok, YouTube @coachdianaleighEmail: coachdianaleigh@gmail.com
We dive into the latest research on ketamine's therapeutic potential, including its role in treating ischemic stroke, postoperative cognitive dysfunction (POCD), and PTSD. You'll hear how scientists are studying its effects on brain regions like the hippocampus and amygdala, as well as its impact on neuroinflammation, fear memory, and neurogenesis. We'll also explore ketamine's use in anesthesia, its interactions with drugs like oral morphine, and how it's monitored using tools like EEG. From molecular techniques like RT-qPCR and Western blotting to real-world applications—this episode breaks down the science driving ketamine's future in medicine. Here's some of what you'll hear in this episode:
New study shows mood, attention, brain function improvements after 2-week smartphone “fast”; Natural ways to combat the pain of neuropathy; Solutions for painful swollen lower extremities; Omega-3 reduces depression in bipolar disease; Berberine for blood sugar control; Study demonstrates comprehensive lifestyle program reverses cognitive decline; NSAIDs for knee pain—more is not better; Nighttime pistachio snack curbs pre-diabetes.
In dieser Folge zerlegen wir einen der größten Irrtümer der Persönlichkeitsentwicklung:Dass du dich allein mit Willenskraft, Affirmationen und Routinen verändern kannst.Ich zeige dir anhand des Diathese-Stress-Modells,warum so viele Coachings scheitern und wie deine genetische Veranlagung (Diathese) darüber entscheidet, wie du auf Stress, Druck und Veränderung reagierst.Du erfährst:▪️ Warum Menschen mit denselben Tools völlig unterschiedliche Ergebnisse erzielen▪️ Welche Rolle Genvarianten wie BDNF, FKBP5 oder COMT dabei spielen▪️ Warum es gefährlich sein kann, dich durch Prozesse zu zwingen, die nicht zu deinem System passen▪️ Und was du stattdessen brauchst, um dich nachhaltig und gesund zu verändernWenn du endlich verstehen willst,warum du dich oft blockiert fühlst und was das mit deiner Biologie zu tun hat, dann ist diese Folge für dich.
Welcome or welcome back to Authentically ADHD, the podcast where we embrace the chaos and magic of the ADHD brain. Im carmen and today we're diving into a topic that's as complex as my filing system (which is to say, very): ADHD and its common co-occurring mood and learning disorders. Fasten your seatbelts (and if you're like me, try not to get distracted by the shiny window view) – we're talking anxiety, depression, OCD, dyslexia, dyscalculia, and bipolar disorder, all hanging out with ADHD.Why cover this? Because ADHD rarely rides solo. In fact, research compiled by Dr. Russell Barkley finds that over 80% of children and adults with ADHD have at least one other psychiatric disorder, and more than half have two or more coexisting conditions. Two-thirds of folks with ADHD have at least one coexisting condition, and often the classic ADHD symptoms (you know, fidgeting, daydreaming, “Did I leave the stove on?” moments) can overshadow those other disorders. It's like ADHD is the friend who talks so loud at the party that you don't notice the quieter buddies (like anxiety or dyslexia) tagging along in the background.But we're going to notice them today. With a blend of humor, sass, and solid neuroscience (yes, we can be funny and scientific – ask me how I know!), we'll explore how each of these conditions shows up alongside ADHD. We'll talk about how they can be misdiagnosed or missed entirely, and—most importantly—we'll dish out strategies to tell them apart and tackle both. Knowledge is power and self-awareness is the key, especially when it comes to untangling ADHD's web of quirks and comrades in chaos. So, let's get into it!ADHD and Anxiety: Double Trouble in OverdriveLet's start with anxiety, ADHD's frequent (and frantic) companion. Ever had your brain ping-pong between “I can't focus on this work” and “I'm so worried I'll mess it up”? That's ADHD and anxiety playing tango in your head. It's a double whammy: ADHD makes it hard to concentrate, and anxiety cranks up the worry about consequences. As one study notes, about 2 in 5 children with ADHD have significant problems with anxiety, and over half of adults with ADHD do as well. In other words, if you have ADHD and feel like a nervous wreck half the time, you're not alone – you're in very good (and jittery) company.ADHD and anxiety can look a lot alike on the surface. Both can make you restless, unfocused, and irritable. I mean, is it ADHD distractibility or am I just too busy worrying about everything to pay attention? (Hint: it can be both.) Especially for women, ADHD is often overlooked and mislabeled as anxiety. Picture a girl who can't concentrate in class: if she's constantly daydreaming and fidgety, one teacher calls it ADHD. Another sees a quiet, overwhelmed student and calls it anxiety. Same behavior, different labels. Women in particular have had their ADHD misdiagnosed as anxiety or mood issues for years, partly because anxious females tend to internalize symptoms (less hyperactive, more “worrier”), and that masks the ADHD beneath.So how do we tell ADHD and anxiety apart? One clue is where the distraction comes from. ADHD is like having 100 TV channels in your brain and someone else is holding the remote – your attention just flips on its own. Anxiety, on the other hand, is like one channel stuck on a horror movie; you can't focus on other things because a worry (or ten) is running on repeat. An adult with ADHD might forget a work deadline because, well, ADHD. An adult with anxiety might miss the deadline because they were paralyzed worrying about being perfect. Both end up missing the deadline (relatable – ask me how I know), but for different reasons.Neuroscience is starting to unravel this knot. There's evidence of a genetic link between ADHD and anxiety – the two often run in the family together. In brain studies, both conditions involve irregularities in the prefrontal cortex (the brain's command center for focus and planning) and the limbic system (emotion center). Essentially, if your brain were a car, ADHD means the brakes (inhibition) are a bit loose, and anxiety means the alarm system is hyper-sensitive. Combine loose brakes with a blaring alarm and you get… well, us. Fun times, right?Here's an interesting tidbit: Females with ADHD are more likely to report anxiety than males. Some experts think this is partly due to underdiagnosed ADHD – many girls grew up being told they were just “worrywarts” when in fact ADHD was lurking underneath, making everyday life more overwhelming and thus feeding anxiety. As Dr. Thomas Brown (a top ADHD expert) points out, emotional regulation difficulties (like chronic stress or worry) are characteristic of ADHD, even though they're not in the official DSM checklist. Our ADHD brains can amplify emotions – so a normal worry for someone else becomes a five-alarm fire for us.Now, action time: How do we manage this dynamic duo? The first step is getting the right diagnosis. A clinician should untangle whether symptoms like trouble concentrating are from anxiety, ADHD, or both. They might ask: Have you always had concentration issues (pointing to ADHD), or did they start when your anxiety kicked into high gear? Also, consider context – ADHD symptoms occur in most settings (school, work, home), while pure anxiety might spike in specific situations (say, social anxiety in crowds, or panic attacks only under stress).Treatment has to tackle both. Therapy – especially Cognitive Behavioral Therapy (CBT) – is a rockstar here. CBT can teach you skills to manage worry (hello, deep breathing and logical rebuttals to “what if” thoughts) and also help with ADHD organization hacks (like breaking tasks down, creating routines). Many find that medication is needed for one or both conditions. Stimulant meds (like methylphenidate or amphetamines) treat ADHD, but in someone with severe anxiety, a stimulant alone can sometimes ramp up the jitters. In fact, children (and adults) with ADHD + anxiety often don't respond as well to ADHD meds unless the anxiety is also addressed. Doctors might add an SSRI or other anti-anxiety medication to the mix, or choose a non-stimulant ADHD med if stimulants prove too anxiety-provoking.Let me share a quick personal strategy (with a dash of humor): I have ADHD and anxiety, so my brain is basically an internet browser with 50 tabs open – and 10 of them are frozen on a spinning “wheel of doom” (those are the anxieties). One practical tip that helps me distinguish the two is to write down my racing thoughts. If I see worries like “I'll probably get fired for sending that email typo” dominating the page, I know anxiety is flaring. If the page is blank because I got distracted after one sentence... well, hello ADHD! This silly little exercise helps me decide: do I need to do some calming techniques, or do I need to buckle down and use an ADHD strategy like the Pomodoro method? Try it out: Knowledge is power, and self-awareness is the key.Quick Tips – ADHD vs Anxiety: When in doubt, ask what's driving the chaos.* Content of Thoughts: Racing mind full of specific worries (anxiety) vs. racing mind full of everything except what you want to focus on (ADHD).* Physical Symptoms: Anxiety often brings friends like sweaty palms, racing heart, and tummy trouble. ADHD's restlessness isn't usually accompanied by fear, just boredom or impulsivity.* Treatment Approaches: For co-occurring cases, consider therapy and possibly a combo of medications. Experts often treat the most impairing symptom first – if panic attacks keep you homebound, address that alongside ADHD. Conversely, untreated ADHD can actually fuel anxiety (ever notice how missing deadlines and forgetfulness make you more anxious? Ask me how I know!). A balanced plan might be, say, stimulant medication + talk therapy for anxiety, or an SSRI combined with ADHD coaching. Work closely with a professional to fine-tune this.Alright, take a breath (seriously, if you've been holding it – breathing is good!). We've tackled anxiety; now let's talk about the dark cloud that can sometimes follow ADHD: depression.ADHD and Depression: When the Chaos Brings a CloudADHD is often associated with being energetic, spontaneous, even optimistic (“Sure, I can start a new project at 2 AM!”). So why do so many of us also struggle with depression? The reality is, living with unmanaged ADHD can be tough. Imagine years of what Dr. Russell Barkley calls “developmental delay” in executive function – always feeling one step behind in managing life, despite trying so hard. It's no surprise that about 1 in 5 kids with ADHD also has a diagnosable depression, and studies show anywhere from 8% to 55% of adults with ADHD have experienced a depressive disorder in their lifetime. (Yes, that range is huge – it depends how you define “depression” – but even on the low end it's a lot.) Dr. Barkley himself notes that roughly 25% of people with ADHD will develop significant depression by adulthood. In short, ADHD can come with a case of the blues (not the fun rhythm-and-blues kind, unfortunately).So what does ADHD + depression look like? Picture this: You've got a pile of unfinished projects, bills, laundry – the ADHD “trail of crumbs.” Initially, you shrug it off or maybe crack a joke (“organizational skills, who's she?”). But over time, the failures and frustrations can chip away at your self-esteem. You start feeling helpless or hopeless: “Why bother trying if I'm just going to screw it up or forget again?” That right there is the voice of depression sneaking in. ADHD's impulsivity might also lead to regrettable decisions or conflicts that you later brood over, another pathway to depressed mood.In fact, the Attention Deficit Disorder Association points out that ADHD's impact on our lives – trouble with self-esteem, work or school difficulties, and strained relationships – can contribute to depression. It's like a one-two punch: ADHD creates problems; those problems make you sad or defeated, which then makes it even harder to deal with ADHD. Fun cycle, huh?Now, depression itself can mask as ADHD in some cases, especially in adults. Poor concentration, low motivation, fatigue, social withdrawal – these can appear in major depression and look a lot like ADHD symptoms. If an adult walks into a doctor's office saying “I can't focus and I'm procrastinating a ton,” a cursory eval might yield an ADHD diagnosis. But if that focus problem started only after they, say, lost a loved one or fell into a deep funk, and they also feel worthless or have big sleep/appetite changes, depression may be the primary culprit. On the flip side, a person with lifelong ADHD might be misdiagnosed as just depressed, because they seem down or overwhelmed. As always, timeline is key: ADHD usually starts early (childhood), whereas depression often has a more defined onset. Also, ask: Is the inability to focus present even when life's going okay? If yes, ADHD is likely in the mix. If the focus issues wax and wane with mood, depression might be the driver.There's also a nuance: ADHD mood issues vs. clinical depression. People with ADHD can have intense emotions and feel demoralized after a bad day, but often these feelings can lift if something positive happens (say, an exciting new interest appears – suddenly we have energy!). Clinical depression is more persistent – even good news might not cheer you up much. As Dr. Thomas Brown emphasizes, ADHD includes difficulty regulating emotion; an ADHD-er might feel sudden anger or sadness that's intense but then dissipates . By contrast, depression is a consistent low mood or loss of pleasure in things over weeks or months. Knowing this difference can be huge in sorting out what's going on.Now, how do we deal with this combo? The good news: many treatments for depression also help ADHD and vice versa. Therapy is a prime example. Cognitive Behavioral Therapy and related approaches can address negative thought patterns (“I'm just a failure”) and also help with practical skills for ADHD (like scheduling, or as I call it, tricking my brain into doing stuff on time). There are even specialized therapies for adults with ADHD that blend mood and attention strategies. On the medication front, sometimes a single med can pull double duty. One interesting option is bupropion (Wellbutrin) – an antidepressant that affects dopamine and norepinephrine, which can improve both depression and ADHD symptoms in some people. There's also evidence that stimulant medications plus an antidepressant can be a powerful combo: stimulants to improve concentration and energy, antidepressant to lift mood. Psychiatrists will tailor this to the individual – for instance, if someone is severely depressed (can't get out of bed), treating depression first may be priority. If the depression seems secondary to ADHD struggles, improving the ADHD could automatically boost mood. Often, it's a balancing act of treating both concurrently – maybe starting an antidepressant and an ADHD med around the same time, or ensuring therapy covers both bases.Let's not forget lifestyle: exercise, sleep, nutrition – these affect both ADHD and mood. Regular exercise, for example, can increase BDNF (a brain growth factor) and neurotransmitters that help both attention and mood. Personally, I found that when I (finally) started a simple exercise routine, my mood swings evened out a bit and my brain felt a tad less foggy. (Of course, starting that routine required overcoming my ADHD inertia – ask me how I know that took a few tries... or twenty.)Quick Tips – ADHD vs Depression:* Check Your Joy Meter: With ADHD alone, you can still feel happy/excited when something engaging happens (ADHD folks light up for interesting tasks!). With depression, even things you normally love barely register. If your favorite hobbies no longer spark any joy, that's a red flag for depression.* All in Your Head? ADHD negative thoughts sound like “Ugh, I forgot again, I need a better system.” Depression thoughts sound like “I forgot again because I'm useless and nothing will ever change.” Listen to that self-talk; depression is a sneaky bully.* Professional Help: A thorough evaluation can include psychological tests or questionnaires to measure attention and mood separately. For treatment, consider a combined approach: therapy (like CBT or coaching) plus meds as needed. According to research, a mix of stimulant medication and therapy (especially CBT) can help treat both conditions. And remember, addressing one can often relieve the other: improve your ADHD coping skills, and you might start seeing hope instead of disappointment (boosting mood); treat your depression, and suddenly you have the energy to tackle that ADHD to-do list.Before we move on, one more important note: if you ever have thoughts of self-harm or suicide, please reach out to a professional immediately. Depression is serious, and when compounded with ADHD impulsivity, it can be dangerous. There is help, and you're not alone – so many of us have been in that dark place, and it can get better with the right support. Knowledge is power and self-awareness is the key, yes, but sometimes you also need a good therapist, maybe a support group, and possibly medication to truly turn things around. There's no shame in that game.Alright, deep breath. It's getting a bit heavy in here, so let's pivot to something different: a condition that seems like the opposite of ADHD in some ways, yet can co-occur – OCD. And don't worry, we'll crank the sass back up a notch.ADHD and OCD: The Odd Couple of AttentionWhen you think of Obsessive-Compulsive Disorder (OCD), you might picture someone extremely organized, checking the stove 10 times, everything neat and controlled. When you think ADHD… well, “organized” isn't the first word that comes to mind, right?
I'm so excited to share today's episode with you because it's packed with so many actionable tips to help you cultivate more happiness in your everyday life—and understand what might be getting in the way of it. I'm joined by nine incredible leading happiness experts. We're diving deep into the truth about dopamine and serotonin—what they really are, and why dopamine might actually not want you to be happy. We explore why we often feel less satisfied even after getting exactly what we thought we wanted, and how the “when I get this, I'll be happy” mindset is secretly keeping us stuck. In this episode, we get into: Dopamine & serotonin on happiness How our society prevents happiness Having purpose in life Happiness within our career Happiness with social media & news consumption Perfectionism on happiness & so much more! Check out the full episodes of The Liz Moody Podcast discussed today: Neuroscience Hacks For Optimizing Dopamine, Serotonin, Oxytocin, BDNF, And More with Nicole Vignola The REAL Reason You're Burnt Out (And Exactly How To Fix It) with Israa Nasir My Top Micro Habits: Proven Ways To Get Happier & Healthier In 5 Minutes Or Less with Liz Moody Anyone Can Become More Optimistic—Here's How with Dr. Sue Varma Why We Have No Work/Life Balance + How To Fix It with Simone Stolzoff The Hidden Elements of Happiness That No One Is Talking About with Gretchen Rubin 3 Things To STOP Doing In Your 20s & 30s To Be Happier, Healthier & Wealthier with Liz Moody The Seven-Minute Secret To Happiness That No One Is Talking About with Dr. Dacher Keltner Science-Backed Hacks to MAJORLY Reduce Stress When The World Gets Overwhelming with Dr. Jenny Taitz Ready to uplevel every part of your life? Order Liz's book 100 Ways to Change Your Life: The Science of Leveling Up Health, Happiness, Relationships & Success now! Connect with Liz on Instagram @lizmoody or online at www.lizmoody.com. Subscribe to the substack by visiting https://lizmoody.substack.com/welcome. To join The Liz Moody Podcast Club Facebook group, go to www.facebook.com/groups/thelizmoodypodcast. This episode is brought to you completely free thanks to the following podcast sponsors: AG1: visit DrinkAG1.com/LizMoody and get your FREE year supply of Vitamin D and 5 free travel packs today. LMNT: go to DrinkLMNT.com/LizMoody to get a free LMNT sample pack with any order. IQ Bar: Text LIZ to 64000 for 20% off all IQBAR products plus FREE shipping. OSEA: get 10% off your first order at oseamalibu.com with code LIZMOODY or LIZMOODY10. The Liz Moody Podcast cover art by Zack. The Liz Moody Podcast music by Alex Ruimy. Formerly the Healthier Together Podcast. This podcast and website represents the opinions of Liz Moody and her guests to the show. The content here should not be taken as medical advice. The content here is for information purposes only, and because each person is so unique, please consult your healthcare professional for any medical questions. The Liz Moody Podcast Episode 345. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of Research Renaissance, host Deborah Westphal sits down with Dr. Prabesh Bhattarai, Associate Research Scientist - The Taub Institute for Research on Alzheimer's Disease, the aging Brain, Columbia University Irving Medical Center and a 2024 Toffler Scholar.Dr. Bhattarai shares his groundbreaking work on regenerative biology and how understanding the remarkable ability of certain fish to regrow neurons could eventually lead to new treatments for neurodegenerative diseases like Alzheimer's.They explore:
“Simple movements, taking care of your mental health, and building deeper connections— those are drivers of longevity,” explains Drew Ramsey, M.D. Drew Ramsey, M.D., board-certified psychiatrist, psychotherapist, and author, joins us today to explain how all of us can take simple and actionable steps to improve our mental health, including the importance of dreams, adding in more movement, plus: - Ramsey's practice (~1:30) - The drivers of the mental health epidemic (~3:10) - Exercise & BDNF (~10:!5) - The 9 tenets for better mental health (~17:30) - The importance of connection (~19:00) - Gender differences (~23:25) - Cultural shifts & alcohol consumption (~27:55) - Cannabis & psychedelics (~30:00) - The importance of sleep & dreams (~35:00) - The power of nutrition (~42:00) - The role of supplements (~46:00) - How to unburden yourself (~48:50) - Purpose & spirituality (~50:05) Referenced in the episode: - Follow him on Instagram (@drewramseymd) - Check out his website (https://drewramseymd.com/) - Pick up his book, Healing the Modern Brain Thanks for listening to this special episode—brought to you by Solaray, the #1 vitamin and mineral supplement brand in health food stores. Try their Liposomal Multivitamin for Women today at 30% off. Visit Solaray.com and use code MINDBODYGREEN: http://solaray.com/liposomal-womensWe hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices
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Sit to Stand Test & Surgical Vitality PodcastFIVE PRIMARY POINTS of this week's PODCAST* Tame the “Brain-on-Fire” ProblemRunaway neuro-inflammation accelerates multiple sclerosis, stroke, Alzheimer's and Parkinson's. Prioritize lifestyle tactics that cross the blood–brain barrier—sleep, anti-inflammatory diet, and stress control—while watching developments in next-gen brain-penetrant drugs.* Ice Is Medicine: Use Cold Exposure to Re-Route Energy Away from InflammationBrief, controlled cold stress (a 90-second cold shower in the morning, progressing to 3–5 min ice baths or cold plunges 2–3×/week) forces the body to burn calories for heat, starving inflammatory pathways and even improving auto-immune outcomes in animal models. Always clear major cold work with your physician first.* Move Before You Medicate for Depression & AnxietyA meta-analysis of 26 RCTs (>2,500 participants) shows exercise rivals—or beats—pharmacotherapy for mood disorders. Aim for a baseline of 30 min brisk walking or resistance work most days; any movement is better than none, and mixed aerobic + strength routines offer the strongest mental-health bump.* Inflammation in Your 20s Predicts Brainpower in Your 40sAn 18-year cohort study linked consistently high—or even slowly rising—CRP levels with poorer mid-life cognition. Action: get a baseline CRP, track it yearly, and deploy weight control, resistance training, and nutrient-dense, time-restricted eating (“eat less, eat less often”) to keep levels low.* Double-Down on Purpose & Gratitude—They're Biological Anti-InflammatoriesA strong life purpose lowers IL-6 and CRP, while daily gratitude practice calms the amygdala and drops TNF-α. Practical micro-habit: each week thank five people (voice or face-to-face), and block 15 minutes on Sunday to revisit your “why.” Pair with twice-weekly strength training to release anti-inflammatory myokines and boost BDNF for memory.Listen to the full podcast to learn more and please leave your comments below. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit vitalityexplorers.substack.com/subscribe
Get 40% Off At-Home NAD Shots Want a powerful energy boost without leaving home? Shed delivers clinical-grade NAD+ shots straight to your door—no appointment needed. NAD supports cellular repair, brain function, and longevity, making it one of our go-to biohacking tools. Get 40% off your first order at tryshed.com with code NURSEDOZA. In this episode of the School of Doza podcast, we go full Cellular Energy 101: How to Improve Mitochondrial Function Naturally. Nurse Doza breaks down the five most impactful ways to boost energy from the inside out—starting with sunlight and ending with glutathione. If you're tired, sluggish, or just want to age better, this episode is your roadmap. 5 KEY TAKEAWAYS Sunlight—especially morning light—activates your mitochondria to naturally boost energy. Resveratrol supplements (like MITOCHONDRIAC) trigger AMPK, improving mitochondrial function. NAD+ injections can stimulate ATP production and mitochondrial biogenesis. Fasting and insulin regulation are essential for mitochondrial health and longevity. Glutathione protects your mitochondria from free radical damage and oxidative stress. FEATURED PRODUCT Mitochondriac, featuring pure trans-resveratrol and quercetin, is designed to activate AMPK and enhance mitochondrial function, promoting cellular energy production and healthy aging—exactly what's needed to implement the strategies discussed in this episode. Try Mitochondriac TIMESTAMPS 00:00 START – Welcome to the energy episode 05:00 – What mitochondria actually do (and why they matter) 07:00 – Energy vs waste: the balance of ATP and byproducts 08:00 – Why sunlight is your mitochondria's best friend 11:00 – Red light therapy and how it mimics the sun 12:00 – Resveratrol: how it fuels your cells 14:00 – The AMPK gene, explained simply 16:00 – Autophagy and mitochondrial biogenesis 17:00 – NAD+ therapy: weekly injections, daily energy 19:00 – The electron transport chain 101 22:00 – Mitochondrial enzymes that need NAD+ to function 24:00 – Regulating insulin and why fasting helps 27:00 – Ketones and caloric restriction for brain health 30:00 – The role of glutathione in detoxifying your cells 32:00 – Nurse Doza's 5-part mitochondrial optimization routine RESOURCES MENTIONED Red and Near-Infrared Light and Mitochondrial ATP/ROS Regulation NIR Light Reduces Cell Death in Parkinson's Disease Models Red Light Therapy and Mitochondrial Benefits Resveratrol and AMPK Activation Mitochondria, NAD+, and the Electron Transport Chain Ketones, BDNF, and Fasting Benefits Glutathione as a Mitochondrial Antioxidant SLC25A39 and GSH Transport into Mitochondria
Transform your midday slump into peak performance with this scientifically-engineered restorative audio experience featuring our precision-tuned therapeutic frequency matrix. This 5-minute guided soundscape combines cutting-edge neuroscience with ancient healing frequencies to deliver maximum cognitive restoration.Our Therapeutic Frequency Stack:- 40Hz - Gamma wave entrainment for enhanced brain clearance, memory consolidation, and neural synchronization- 256Hz - Root chakra frequency promoting grounding and physical restoration- 285Hz - Cellular repair frequency supporting tissue regeneration during rest- 288Hz - Harmonic bridge frequency enhancing overall system balance- 320Hz - Solar plexus activation for renewed energy and confidence- 341.3Hz - Heart coherence frequency promoting emotional balance- 384Hz - Third eye resonance supporting intuitive clarity- 3Hz Binaural Beat - Delta wave induction for rapid sleep onset and deep restorationTop 3 Power Nap Usages:1. The 3PM Performance Crash - When post-lunch fatigue threatens your productivity and that important deadline looms. Studies show this timing aligns with natural circadian dips, making it ideal for a restorative reset.2. Pre-Presentation Power-Up - Before high-stakes meetings, presentations, or creative sessions when you need peak mental clarity and confidence. Research confirms 20-minute naps boost problem-solving abilities by up to 40%.3. Shift Work Recovery - For healthcare workers, first responders, or anyone managing irregular schedules. Strategic power naps help recalibrate disrupted circadian rhythms and maintain cognitive sharpness during critical hours.Our dynamic frequency layering reduces sleep latency by 15-38%, increases slow-wave sleep efficiency, and lowers cortisol by 22%. Wake refreshed without grogginess, with enhanced memory, sharper focus, and renewed energy to conquer your day.Based on peer-reviewed neuroscience research. Individual results may vary. For extended sessions and personalized soundscapes, explore our premium Restorative Audio collection.Send us a textSupport the show
Transform your midday slump into peak performance with this scientifically-engineered restorative audio experience featuring our precision-tuned therapeutic frequency matrix. This 15-minute soundscape combines cutting-edge neuroscience with ancient healing frequencies to deliver maximum cognitive restoration.Our Therapeutic Frequency Stack:40Hz - Gamma wave entrainment for enhanced brain clearance, memory consolidation, and neural synchronization256Hz - Root chakra frequency promoting grounding and physical restoration285Hz - Cellular repair frequency supporting tissue regeneration during rest288Hz - Harmonic bridge frequency enhancing overall system balance320Hz - Solar plexus activation for renewed energy and confidence341.3Hz - Heart coherence frequency promoting emotional balance384Hz - Third eye resonance supporting intuitive clarity3Hz Binaural Beat - Delta wave induction for rapid sleep onset and deep restorationTop 3 Power Nap Usages:The 3PM Performance Crash - When post-lunch fatigue threatens your productivity and that important deadline looms. Studies show this timing aligns with natural circadian dips, making it ideal for a restorative reset.Pre-Presentation Power-Up - Before high-stakes meetings, presentations, or creative sessions when you need peak mental clarity and confidence. Research confirms 20-minute naps boost problem-solving abilities by up to 40%.Shift Work Recovery - For healthcare workers, first responders, or anyone managing irregular schedules. Strategic power naps help recalibrate disrupted circadian rhythms and maintain cognitive sharpness during critical hours.Our dynamic frequency layering reduces sleep latency by 15-38%, increases slow-wave sleep efficiency, and lowers cortisol by 22%. Wake refreshed without grogginess, with enhanced memory, sharper focus, and renewed energy to conquer your day.Based on peer-reviewed neuroscience research. Individual results may vary. For extended sessions and personalized soundscapes, explore our premium Restorative Audio collSend us a textSupport the show
What if healing the brain wasn't just about rest and rehab—but light? Most people think of concussion treatment as pacing, physio, maybe some cognitive rehab… but what if we've been missing a powerful, science-backed tool this whole time? Let's be real: Photobiomodulation sounds like something straight out of a sci-fi film. And if you're a clinician or someone on a healing journey, you might be wondering—how could a helmet that shines light on your head actually make a difference? In this episode of the Concussion Nerds Podcast, Natasha is joined by Chris Garvin from Neuronic, a cutting-edge neurotech company that's changing how we support the brain using light. Together, they break down the science of photobiomodulation in a way that's actually understandable—and explore how it's being used to help people with persistent concussions, cognitive decline, and more. BY THE TIME YOU FINISH LISTENING, YOU'LL DISCOVER: What photobiomodulation actually is—and how Neuronic's device is using it to improve brain function How red light therapy has evolved beyond skincare to support concussion recovery and neurodegenerative care The real-life stories of patients and families seeing life-changing shifts through this technology What new research says about boosting BDNF (aka brain fertilizer) without needing intense aerobic exercise This episode is a must-listen for clinicians who want to stay on the cutting edge of evidence-informed care—and for anyone on a healing journey who's curious about non-invasive tools that can support real recovery. If you've never heard of Neuronic or photobiomodulation before, prepare to have your mind (and brain) blown. Let's connect! Instagram: @concussionnerds https://www.instagram.com/concussionnerds/ @natasha.wilch https://www.instagram.com/natasha.wilch/ Email: hello@natashawilch.com Website: https://www.natasha-wilch.com Learn how to connect & understand your nervous system so you can have greater outcomes in your health & healing journey: Grab a copy of the workbookhttps://www.natashawilch.com/understanding-connecting-your-nervous-system-1 Join the Clinician's Edge to have Your Weekly Taste of Neuro Wisdom here: https://www.natashawilch.com/clinicians-edge Join the Concussion Mini School and Membership! Get the support and resources you need for concussion recovery: Mini School: https://www.natashawilch.com/concussion-mini-school Membership: https://www.natashawilch.com/concussion-mini-school-the-membership
Need a pick-me-up? Skip the coffee and try a movement bite. Jessica Schatz is a celebrity trainer and biomechanics and ProACTIVE Aging expert. She's trained professional athletes, Broadway stars and Hollywood actors for decades. Those athletes and performers need to maintain energy to perform. Jessica says the key to maintaining energy and aging well isn't destroying yourself in a two-hour gym workout. It's a lot easier than that. It's incorporating five-minute exercise breaks frequently into your day. Even 30 seconds of jumping jacks, pushups or squats can go a long way. Jessica calls them movement bites. "They increase your blood flow. They increase your heart rate. And they start to release these proteins, these Myokines, and they also release a protein called BDNF, Brain Derived Neurotrophic Factor. It's like fertilizer for your brain," Schatz said. It's good news for anyone not crazy about chasing the elusive runner's high. Creating a positive neurfeedback loop doesn't have to leave you exhausted. It just needs to be consistent. "You're literally teaching yourself to foster a relationship with movement that's positive," Schatz said. Follow Jessica: Facebook: @thecoreexpert Instagram: @TheCoreExpert YouTube: @TheCoreExpert On this Dying to Ask: A deep dive into the science of hope molecules 5 movement bites you can do sitting in your car or at your desk How to plan your own "pick-me-ups" to improve mood and energy And what it's like to be a celebrity trainer to stars like Ashley Olsen and NBA players Other places to listen CLICK HERE to listen on iTunes CLICK HERE to listen on Stitcher CLICK HERE to listen on Spotify See more coverage of top California stories here | Download our app | Subscribe to our morning newsletter | Find us on YouTube here and subscribe to our channel
In this powerful episode we sit down with Britney Marsden, also known as "The PMDD Chick," to explore the multifaceted experience of living with Premenstrual Dysphoric Disorder (PMDD). Britney opens up about her personal journey with PMDD — from misdiagnosis and confusion to self-advocacy and empowerment. She dives into the many possible root causes of PMDD, including hormonal imbalances, gut health, nutrient deficiencies, and environmental factors, emphasizing that PMDD isn't just “in your head” — it's often the result of complex physiological and psychological interactions. One key theme throughout the conversation is the role of trauma, and how unresolved emotional wounds can manifest or intensify PMDD symptoms. Britney also offers heartfelt and empowering advice to women who are struggling: from finding the right practitioners to the importance of self-compassion, community, and nervous system regulation. Her message is both hopeful and validating, reminding listeners that healing is possible — and that they're not alone.Britney Marsden, known as "The PMDD Chick," is a dedicated Women's Health Coach specializing in Premenstrual Dysphoric Disorder (PMDD). Drawing from her own experience overcoming severe PMDD, she has become a trusted source of support and knowledge for women facing this often misunderstood condition. As a qualified Women's Health Coach, Britney empowers women to identify and address factors that exacerbate PMDD symptoms. Empowering women to identify contributing factors that may exacerbate PMDD symptoms, Britney offers holistic, personalized solutions through her online PMDD programs, which provide practical strategies and insights to help women manage and alleviate their symptoms effectively.SHOW NOTES:0:39 Welcome to the show!3:18 About Britney Marsden4:28 Welcome Britney to the podcast!5:39 What is PMDD?7:12 Her diagnosis & journey through12:36 Traditional solutions for PMDD14:09 Understanding the Hormonal Cycle17:04 Genetic predispositions for PMDD18:18 BDNF, Trauma & ADD correlations19:17 MCAS, Histamine & Hidden Infections22:07 The #1 contributor to PMDD25:56 Talk therapies & ISDTP31:05 *MY ALIGN MAT*33:05 Plant Medicines & Microdosing37:04 Her root cause spinal infection40:41 POTS, MCAS & Sinus Tachycardia42:49 How she persevered & turned a corner50:25 Supplements & Biohacks for PMDD53:24 Healing gut dysbiosis55:57 Coexisting comorbidities1:00:28 Her final piece of advice1:03:40 Where to find her1:04:57 Thanks for tuning in!RESOURCES:Website: www.thepmddchick.comHer Health Confessions PodcastTikTok: https://www.tiktok.com/@thepmddchickInstagram: https://www.instagram.com/thepmddchick/Intensive Short-Term Dynamic PsychotherapyMyAlignMat - code: BIOHACKERBABESPuori - Discount code: BIOHACKERBABESOur Sponsors:* Check out Puori: https://Puori.com/BIOHACKERBABESSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands
Brain Reboot is a Brain Rot remedy that is a focused restorative audio experience designed to counter the cognitive effects of digital overwhelm and information overload through precisely calibrated frequency combinations.This science-backed audio therapy integrates:- 40Hz gamma frequencies to enhance neural synchronization and stimulate BDNF production- Beta wave frequencies (13-30Hz) to improve focus and analytical thinking- Theta waves (4-7Hz) to facilitate emotional regulation and creative problem-solving- Solfeggio frequencies including 417Hz and 528Hz to promote cellular repairThe composition progresses through three strategic phases:- Clearing - Dissolves mental fog and restores attentional capacity- Synchronizing - Realigns neural oscillations disrupted by digital multitasking- Strengthening - Enhances cognitive resilience and executive functionClinical studies show that consistent listening for 20 minutes daily can improve attention span by 35% and reduce mental fatigue by 50% after four weeks.Experience renewed mental clarity, improved memory consolidation, and enhanced focus as this acoustic intervention helps recalibrate your brain's natural rhythms in our hyper-digital world.Send us a textSupport the show
Brain Reboot is a Brain Rot remedy that is a focused restorative audio experience designed to counter the cognitive effects of digital overwhelm and information overload through precisely calibrated frequency combinations.This science-backed audio therapy integrates:- 40Hz gamma frequencies to enhance neural synchronization and stimulate BDNF production- Beta wave frequencies (13-30Hz) to improve focus and analytical thinking- Theta waves (4-7Hz) to facilitate emotional regulation and creative problem-solving- Solfeggio frequencies including 417Hz and 528Hz to promote cellular repairThe composition progresses through three strategic phases:- Clearing - Dissolves mental fog and restores attentional capacity- Synchronizing - Realigns neural oscillations disrupted by digital multitasking- Strengthening - Enhances cognitive resilience and executive functionClinical studies show that consistent listening for 20 minutes daily can improve attention span by 35% and reduce mental fatigue by 50% after four weeks.Experience renewed mental clarity, improved memory consolidation, and enhanced focus as this acoustic intervention helps recalibrate your brain's natural rhythms in our hyper-digital world.Send us a textSupport the show
Brain Reboot is a Brain Rot remedy that is a focused restorative audio experience designed to counter the cognitive effects of digital overwhelm and information overload through precisely calibrated frequency combinations.This science-backed audio therapy integrates:- 40Hz gamma frequencies to enhance neural synchronization and stimulate BDNF production- Beta wave frequencies (13-30Hz) to improve focus and analytical thinking- Theta waves (4-7Hz) to facilitate emotional regulation and creative problem-solving- Solfeggio frequencies including 417Hz and 528Hz to promote cellular repairThe composition progresses through three strategic phases:- Clearing - Dissolves mental fog and restores attentional capacity- Synchronizing - Realigns neural oscillations disrupted by digital multitasking- Strengthening - Enhances cognitive resilience and executive functionClinical studies show that consistent listening for 20 minutes daily can improve attention span by 35% and reduce mental fatigue by 50% after four weeks.Experience renewed mental clarity, improved memory consolidation, and enhanced focus as this acoustic intervention helps recalibrate your brain's natural rhythms in our hyper-digital world.Send us a textSupport the show
Le Dr Boris Dufournet est neurologue, spécialisé en neurologie intégrative, médecine métabolique et neurométabolique, avec une approche holistique centrée sur la prévention, la santé globale et la performance durable.https://docteurs-dufournet.com/https://www.youtube.com/@UC3LQDnUdIjIPvykIkZhBc6Ahttps://www.youtube.com/channel/UCOHmHVv5u_mle1HCYUUF_oAhttps://www.linkedin.com/in/borisdufournet/https://x.com/bdufournetCHAPITRES0:00 Introduction0:55 Comprendre les Facteurs de Risque4:42 Le Rôle du Sommeil5:31 Impact de l'Alimentation16:39 Génétique vs Épigénétique21:14 Prévention et Mode de Vie43:51 Test Génétique et Stress47:07 Stratégies de Prise en Charge48:26 Importance de l'activité physique53:48 Impact du BDNF sur la santé cognitive55:26 Rôle des écrans et de la passivité1:01:05 Effets du sucre sur les neurones1:05:15 Diabète cérébral et Alzheimer1:15:02 Vieillissement et perception de la santé1:18:01 Activités cognitives pour prévenir Alzheimer1:30:28 Ménopause et santé hormonale1:33:01 Hormones et risque d'Alzheimer1:35:45 Les limites de la supplémentation hormonale1:38:06 Risques des niveaux hormonaux excessifs1:40:33 La question des doses physiologiques1:42:59 L'importance du régime cétogène1:47:11 Nutrition et sport à travers l'histoire1:49:24 Les effets des glucides sur la santé1:53:33 Le régime cétogène thérapeutique1:58:09 Réflexions sur le métabolisme et les cétones2:02:59 Toxicité des glucides et micronutriments2:08:13 Les phyto-oestrogènes et la testostérone2:10:50 Rôle des fibres et du microbiote2:16:18 Précautions sur le micro-dosing2:21:00 Conclusion et perspectives futuresLIENS PODCASTS• Spotify : https://open.spotify.com/show/1yqDTNuuLcagrP3Z0jwBzz• Apple Podcasts : https://podcasts.apple.com/fr/podcast/biom%C3%A9canique/id1456142727• Youtube : https://www.youtube.com/@UCQlJ8F6VtTThflbkhdJmXWALIENS RÉSEAUX SOCIAUX & SITE• Instagram : https://www.instagram.com/biomecaniquepodcast/• Facebook : https://www.facebook.com/BiomecaniquePodcast/• Tiktok : https://www.tiktok.com/@biomecaniquepodcast• Discord : https://discord.gg/EAe8aKRJ9N• Website : https://biomecaniquepodcast.com• Newsletter : https://biomecaniquepodcast.com/Lettre Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.
Story at-a-glance A study from Brazil's State University of Campinas found twice-weekly weight training for six months preserved brain regions vulnerable to Alzheimer's in older adults with mild cognitive impairment In this research, five of the 22 people in the resistance training group improved enough to no longer meet clinical criteria for cognitive impairment Exercise protects the brain through multiple mechanisms. It stimulates growth factors like BDNF, reduces inflammation, improves cerebral blood flow, and regulates stress hormones that contribute to cognitive decline For optimal longevity benefits, research suggests limiting strength training to 40 to 60 minutes weekly; exceeding 130 to 140 minutes may reverse health gains and even shorten your life Mind-body exercises like yoga and tai chi also benefit brain health. They lower cortisol, reduce anxiety, and improve executive function, attention, and processing speed
The FIT Collective Genetic Insights Series – Episode 1Understanding Genetics, Stress, & Weight with Dr. Ali NovitskyDr. Ali Novitsky, board-certified in obesity medicine, kicks off a new series on how genetics influence health—especially stress responses and weight regulation. She opens with a personal story: during college, despite eating well and exercising, she gained 20 pounds in three months. Genetic testing later revealed a variant in her cortisol receptor gene, causing her body to release excess cortisol under stress—leading to high blood sugar, insulin resistance, and ultimately, weight gain.Cortisol plays a central role in stress response and metabolism. While helpful in short bursts, chronic elevation from ongoing stress can disrupt insulin function, making weight loss more difficult for those with specific genetic variants. For Dr. Novitsky, managing stress—not restricting calories or increasing workouts—was the key to reversing her weight gain.About 30% of people carry this cortisol receptor variant. In her 2022 genetics cohort, 80% tested positive. This highlights the power of personalized health strategies rooted in understanding one's unique genetic makeup.Dr. Novitsky uses Genomind's Mental Health Map, a genetic test offering insight into stress, mood, and focus. One critical gene it reports on is COMT, which affects dopamine breakdown. Individuals with the MetMet variant retain more dopamine—great for focus, but often sensitive to stress. Those with ValVal clear dopamine quickly, leading to impulsivity and a higher likelihood of ADHD.Another important factor is BDNF (brain-derived neurotrophic factor), a gene linked to memory, cognition, and mood. Those with a BDNF variant often need regular exercise to optimize brain health and emotional balance.The takeaway? Health isn't one-size-fits-all. For some, gentle exercise, high-quality sleep, and stress reduction may be far more effective than intense workouts or calorie restriction. Dr. Novitsky's approach integrates genetic awareness into actionable wellness strategies.She also introduces her four-week genetics program, which includes one-time testing, personalized supplement recommendations, and coaching based on individual results. Participants receive a lifelong health blueprint.Future episodes will explore the genetics of eating behaviors, including cravings and satiety. Listeners are encouraged to tune in and learn how DNA influences decisions, habits, and long-term health.Timestamps00:00:00 - Introduction and Personal Story00:01:00 - Understanding Cortisol and Stress00:04:00 - Genetic Testing Insights00:05:30 - Cortisol and Weight Management00:08:00 - COMT Variants and Dopamine00:10:00 - Dopamine Receptor Genes00:11:00 - Strategies for Managing Genetics00:12:00 - Genetics Program Announcement00:13:00 - Custom Recommendations Based on Genetics00:15:00 - The Role of Serotonin and Oxytocin00:16:00 - Genetic Influences on Eating Behaviors00:18:00 - Stress Response and Emotional Eating00:20:00 - The Importance of Awareness00:22:00 - BDNF and Exercise00:23:00 - Micro-Dosed Lithium and Mood00:24:00 - Genetic Predispositions to Worry00:25:00 - Empowerment Through Genetic Awareness00:26:00 - Preview of Next Episode on Eating Genetics00:27:00 - Enrollment for Genetics Program00:28:00 - Closing RemarksWork with Dr. Ali• Beginner Strength Training Program – 12 months for only $199! Enroll TODAY• Total Fitness Program – A 12-month mind-body experience. Enroll HERE• The Fit Collective® x InBody USA/Canada – Get 15% off select models. Click HERE
In this captivating online presentation from the IMMH 2023 conference, board-certified psychiatrist Dr. Achina Stein reveals how the intersection of functional medicine, gut restoration, and psychiatry can lead to lasting healing for depression, anxiety, and other mental health challenges. She explains why the journey takes dedication and time, why psychiatry provides an ideal setting, and why it's worth the effort. She also delves into very concrete clinical advice on the basics of how to implement functional medicine psychiatry. Dr. Achina Stein is a board-certified psychiatrist with over 25 years of clinical experience and serves as the Clinical Director of the Healing Depression Project. Also a certified practitioner with the Institute for Functional Medicine (IFMCP) and a distinguished fellow of the American Psychiatric Association, Dr. Stein was awarded the Exemplary Psychiatrist Award by the National Alliance on Mental Illness. Author of the best-seller What If It's Not Depression, she explains how diet and lifestyle changes - including gut restoration and the 5R protocol - can significantly improve depression, anxiety, and mental health. In this comprehensive presentation, Dr. Stein reveals why standard psychiatric care often falls short by relying on a “silver bullet” approach, the limitations of medications, and why functional medicine offers a revolutionary path forward in psychiatry and mental health treatment. In this episode, discover: Who benefits most from functional medicine and why it's ideal for patients open to diet and lifestyle changes. Why functional medicine analyses food diaries, bowel movements, sleep patterns, exercise, toxin and mould exposure and physical exam/gait analysis in evaluations alongside more conventional psychiatric care. Why a diagnosis isn't always needed for treatment, and why changes to diet and lifestyle can treat conditions before they fully manifest. The link between complex chronic illness and mental health symptoms. The intrinsic connection between depression and inflammation. Other often overlooked root causes of depression and anxiety, including certain medications (e.g., Chantix, Accutane), low cholesterol, low Omega-3, low Vitamin D, thyroid issues, lupus and other autoimmune conditions, and hypoglycemia. Why antidepressants may not always improve symptoms and the potential downsides of their use. The importance of addressing infections, toxins, oxidative stress, hormone imbalances, digestive issues, blood sugar levels, and circadian rhythm in treatment. The 5R protocol (Remove, Replace, Reinoculate, Repair, Rebalance) and its role in restoring gut health for better mental health. Insights from the Dr. Hyman Questionnaire on how chronic toxicity impacts mental health. Why the gut-brain axis is a crucial missing link in treating depression, the mental health risks of gut permeability (leaky gut), and the critical role of diet in maintaining gut and brain health. Ways to strengthen the gut-brain connection and increase BDNF levels through HIIT, fasting, and cold exposure for mental health benefits. The crucial role of exercise in detoxification. Top dietary recommendations for improving depression, anxiety and mental health, including foods to add (vegetables, eggs, beef, fish, quinoa, nuts, seeds, fermented foods) and foods to avoid (caffeine, sugar, dairy, gluten).
Welcome back to Pushing the Limits for another insightful episode. Today, we dive into Kaatsu Training with Sandy Nelson, exploring how this blood flow restriction technique boosts bone density, muscle growth, and brain health for older adults and athletes. Key Points: Research suggests Kaatsu Training helps older adults with osteopenia by improving bone density. It seems likely that Kaatsu Training increases IGF-1 and BDNF, supporting muscle and brain health. The evidence leans toward Kaatsu Training offering neuroprotection, likely via BDNF. Kaatsu Training appears to enhance athlete performance, aiding recovery and strength. What is Kaatsu Training? Kaatsu Training, also known as Blood Flow Restriction (BFR) training, is a method where special bands partially restrict blood flow to the limbs during exercise. This creates a hypoxic environment in the muscles, promoting growth and strength with lighter loads. It was developed in Japan by Dr. Yoshiaki Sato and is used for both rehabilitation and performance enhancement. Benefits for Older Adults and Osteopenia For older adults, Kaatsu Training can help combat osteopenia, a condition with low bone density. Studies suggest it can maintain or increase bone density, reducing fracture risk and supporting mobility, especially for those with joint issues like osteoarthritis. Its low-impact nature makes it suitable, allowing strength gains without excessive joint stress. Impact on IGF-1, BDNF, and Neuroprotection Research indicates Kaatsu Training increases Insulin-like Growth Factor 1 (IGF-1), vital for muscle and bone health, and Brain-Derived Neurotrophic Factor (BDNF), important for brain health. This likely contributes to neuroprotection, potentially reducing neurodegenerative disease risk by supporting cognitive function. Benefits for Athletes For athletes, Kaatsu Training can enhance performance by improving muscle strength and hypertrophy with lighter weights. It can also aid recovery by promoting growth hormones, reducing muscle damage, and allowing more frequent, intense training, benefiting Olympians and professional athletes. Use code "Nelson" at Kaatsu.com for 10% off to start incorporating this training Sandy Nelson Bio "Never before have I seen a modality that gives such a robust hormonal response and promotes the biochemical factors we need to stay strong and sharp as we age." As a KAATSU Certified Coach, Sandy specializes in helping build and maintain your strength and stamina over 50. She also helps healthcare professionals implement KAATSU within their practices and with their clients.
Memory loss is not the only early sign of dementia! Other common cognitive decline symptoms involve the speed at which you process information and your attention and focus.To perform the clock drawing test for dementia, set a timer for 30 seconds and draw a clock with the time set at 10 minutes after 11. To evaluate your results for any dementia risk factors, examine the following:•Were any numbers jumbled or missing?•Did you write all 12 numbers?•Were the numbers spaced correctly?•Were the hands of the clock facing the right direction?•Did you reverse the hour and the minute hands?•Were you unable to complete this in 30 seconds?The clock drawing test is one of the most sensitive indicators of early cognitive deficits and is considered more accurate than memory tests.If you didn't pass this test or you made a mistake, don't worry! You can do many things to support brain health and prevent or reverse dementia.Sugar shrinks your brain, especially the hippocampus, which controls memory. Chronic stress and poor sleep can also contribute to the problem. If you notice any signs of early dementia, increasing BDNF (brain-derived neurotrophic factor) is vital. BDNF helps grow brain tissue and prevents cognitive problems, as well as other issues like depression. Here are the best ways to increase BDNF:•Intermittent fasting •Cold therapy •Deep sleep •Learning difficult tasks or skills•High-intensity interval trainingKetones can also help reverse dementia and protect your brain against cognitive decline. A low-carb diet can increase ketones and has even been shown to reverse diabetes in 10 weeks!MCT oil, coconut oil, and ketone supplements can also provide the brain with ketones. To remain in ketosis, only consume a moderate amount of protein!
Dr. Hoffman continues his conversation with Dr. Drew Ramsey, author of "Eat to Beat Depression and Anxiety: Nourish Your Way to Better Mental Health in Six Weeks."
Dr. Drew Ramsey is a pioneer in the emerging field of Nutritional Psychiatry and author of "Eat to Beat Depression and Anxiety: Nourish Your Way to Better Mental Health in Six Weeks." Dr. Ramsey reviews the remarkable research that has demonstrated the efficacy of diet for improving mental health outcomes. The foods we eat impact our brain function for better or for worse, delivering essential nutrients, fostering a healthy microbiome, combatting inflammation, encouraging neuroplasticity, and supporting neurotransmitters. He is co-developer of the Antidepressant Food Scale that rates foods based on their potential to support well-being. He is also director of the Brain Food Clinic, which offers integrative psychiatric care incorporating “dietary assessment and food prescription along with coaching, meal planning, and hands on skill building in your kitchen.” He believes that no single diet offers a panacea for mental health optimization, but that replacement of ultra-processed food with nutrient-dense alternatives offers the most benefits with ease of compliance.
You've probably heard of HIIT—but have you heard of “REHIT?” This isn't just another workout trend...it's a new science-backed way to train with maximum efficiency and zero wasted time. If you're still jogging, you're wasting hours for minimal results. In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol that's obliterating fitness myths. Forget the treadmill grind. REHIT (Reduced Exertion High-Intensity Training) exercising delivers: • 12% VO₂ max increase • 6x the fitness gains of daily jogging • 62% drop in diabetes risk • 5x more BDNF for brain power —all with just 8 minutes of effort per week. But what is it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows exactly how a brand-new way of exercising is giving explosive results—no matter your age or fitness level. What You'll Learn in This Episode: • Why Zone 2 cardio is outdated advice for most people • The science of REHIT and how 2 sprints beat 2-hour workouts • The shocking data on VO₂ max, insulin sensitivity, and lifespan • How CAROL uses AI to personalize exercise for any age or ability • Why most people fail at fitness—and how to fix it • The real role of lactate, BDNF, and HRV in recovery and resilience • How perimenopausal women benefit more from REHIT than HIIT or jogging • Why adherence—not intensity—is the #1 predictor of results • What to do when you're traveling or don't have access to the tech Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • CAROL Bike Website and use code ‘DAVE' for a discount – https://carolbike.com/ • CAROL Bike Instagram - https://www.instagram.com/thecarolbike/?hl=en • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Introduction to REHIT Training • 00:24 Meet Ulrich Dempfle: The Mind Behind CAROL Bike • 00:51 The Science and Benefits of REHIT • 01:44 Comparing Traditional Cardio to REHIT • 02:32 Dave Asprey's Personal Fitness Journey • 03:43 The Efficiency of REHIT Training • 05:03 Practical Applications and Accessibility of REHIT • 08:22 Addressing Common Concerns and Misconceptions • 11:25 The Future of Fitness: REHIT and Beyond • 18:29 Scientific Validation and Real-World Results • 31:53 Clinical Trials and Tech Integration • 32:06 Upgrade Labs and CAROL Bike • 33:00 Mitochondrial Effectiveness and Insulin Sensitivity • 36:05 Zone Two Training vs. High-Intensity Training • 42:02 REHIT for Perimenopausal Women • 48:18 AI and Personalized Exercise • 57:52 Lactate and Exercise Benefits • 01:01:48 Interval Walking Training • 01:04:01 Conclusion and Future Insights See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
You've probably heard of HIIT—but have you heard of “REHIT?” This isn't just another workout trend...it's a new science-backed way to train with maximum efficiency and zero wasted time. If you're still jogging, you're wasting hours for minimal results. In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol that's obliterating fitness myths. Forget the treadmill grind. REHIT (Reduced Exertion High-Intensity Training) exercising delivers: • 12% VO₂ max increase• 6x the fitness gains of daily jogging • 62% drop in diabetes risk • 5x more BDNF for brain power —all with just 8 minutes of effort per week. But was it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows how a brand-new way of exercising is giving explosive results—no matter your age or fitness level. What You'll Learn in This Episode: • Why Zone 2 cardio is outdated advice for most people • The science of REHIT and how 2 sprints beat 2-hour workouts • The shocking data on VO₂ max, insulin sensitivity, and lifespan • How CAROL uses AI to personalize exercise for any age or ability • Why most people fail at fitness—and how to fix it • The real role of lactate, BDNF, and HRV in recovery and resilience • How perimenopausal women benefit more from REHIT than HIIT or jogging • Why adherence—not intensity—is the #1 predictor of results • What to do when you're traveling or don't have access to the tech Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • CAROL Bike Website and use code ‘DAVE' for a discount – https://carolbike.com/ • CAROL Bike Instagram - https://www.instagram.com/thecarolbike/?hl=en • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Introduction to REHIT Training • 00:24 Meet Ulrich Dempfle: The Mind Behind CAROL Bike • 00:51 The Science and Benefits of REHIT • 01:44 Comparing Traditional Cardio to REHIT • 02:32 Dave Asprey's Personal Fitness Journey • 03:43 The Efficiency of REHIT Training • 05:03 Practical Applications and Accessibility of REHIT • 08:22 Addressing Common Concerns and Misconceptions • 11:25 The Future of Fitness: REHIT and Beyond • 18:29 Scientific Validation and Real-World Results • 31:53 Clinical Trials and Tech Integration • 32:06 Upgrade Labs and CAROL Bike • 33:00 Mitochondrial Effectiveness and Insulin Sensitivity • 36:05 Zone Two Training vs. High-Intensity Training • 42:02 REHIT for Perimenopausal Women • 48:18 AI and Personalized Exercise • 57:52 Lactate and Exercise Benefits • 01:01:48 Interval Walking Training • 01:04:01 Conclusion and Future Insights See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this episode, we explore the critical role of serotonin in shaping sensory maps within the brain, a process vital for interpreting sensory input and navigating the world. Serotonin, a neurotransmitter and neuromodulator synthesized from the aromatic amino acid tryptophan, influences brain development by fine-tuning sensory systems. It modulates neuronal growth, synaptic connections, and plasticity, which are essential for creating accurate sensory maps in regions like the somatosensory cortex, visual cortex, and auditory cortex. These maps serve as blueprints for processing touch, vision, and sound, with serotonin regulating the pruning of connections in the thalamus and cortex to ensure precise sensory wiring.The episode also explores the broader biological implications of serotonin, emphasizing its role in both prenatal and postnatal development. Maternally derived serotonin, supplied via the placenta from the peripheral and enteric nervous systems, significantly influences fetal brain development, affecting proliferation, differentiation, and neuronal migration in sensory regions. Postnatally, serotonin continues to support sensory integration and mood regulation, working alongside oxytocin to facilitate bonding and stress buffering. We explore environmental factors, such as stress and modern lighting, on serotonin synthesis and the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol release. Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Chroma Light Devices, use "autism" for a 10% discount03:12, Sensory Map Introduction and Serotonin's Role, The episode introduces sensory maps, neural blueprints that help the brain interpret sensory inputs like touch, vision, and sound, 04:30, Serotonin's Developmental Impact, Serotonin fine-tunes sensory systems by modulating neuronal growth, synaptic connections, and plasticity, creating precise sensory maps in the somatosensory, visual, and auditory cortices,06:04, Serotonin and Sensory Processing (Visual), Serotonin, sensory processing in the visual cortex08:29, Critical Periods and Neuroplasticity, sensory neurons and connections, pruning10:00, Brain Regions and Serotonin's Mechanisms, Serotonin, axonal guidance, neurogenesis, and migration via microtubules, brain-derived neurotrophic factor (BDNF), glutamate and GABA12:55, Serotonin and Sensory Processing (Somatosensory),13:51, Serotonin and Sensory Processing (Auditory),14:52, Stress and the HPA Axis, Cortisol, circadian rhythms and cortisol spikes, modern environments,16:16 Daylight Computer Company, use "autism" for a $25 discount20:38, Maternal Serotonin and Prenatal Influence; Postnatal Serotonin and Oxytocin; Tryptophan Metabolism and Neurodevelopment, placenta, fetal brain development, proliferation, differentiation, and neuronal migration, serotonin, oxytocin & bonding and stress buffering, TPH1 and TPH2, kynurenine pathwayX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
Today, we're talking about how nootropics and peptides like Semax (See-max) and Selank (SEH-lank) work together to support cognitive health, improve focus, and reduce mental fatigue. Let's start with nootropics. These are substances that are designed to support and enhance mental performance. Some work by improving memory, others help with focus, alertness, or reducing brain fog. Nootropics can be: Natural, like L-theanine or Lion's Mane Nutraceuticals, like Alpha-GPC or CDP-Choline, which support neurotransmitter production Or synthetic, like Modafinil or racetams “RASS-uh-tams”, which are often used off-label to promote wakefulness and focus Most nootropics work by affecting levels of key brain chemicals like dopamine, acetylcholine, or norepinephrine. They don't “make you smarter,” but they can improve how efficiently your brain is working—especially under stress or fatigue. Now, let's talk about peptides—specifically Selank and Semax, which are two of the most well-known nootropic peptides. Selank is more about calming and emotional regulation, while Semax leans into cognitive enhancement and brain performance. Think of Selank as the anti-anxiety sidekick and Semax as the mental sharpener. Selank works by boosting GABA activity, which helps calm the nervous system. That's why it's often used to reduce stress and anxiety without causing drowsiness or dependence — unlike traditional anti-anxiety meds. Interestingly, it also slightly increases BDNF, the brain growth factor that supports memory and learning. Semax, on the other hand, has a much stronger impact on BDNF. It's derived from ACTH, but it doesn't raise cortisol levels. Instead, it enhances BDNF, dopamine, and serotonin activity, making it great for improving focus, mental energy, and even mood. And that's what makes them such a powerful combo for some people. Selank helps create a calm, clear mental space — kind of like reducing background noise — while Semax boosts the brain's signal, improving neuroplasticity, motivation, and mental clarity. Together, they offer a full-spectrum brain support: emotional balance and cognitive performance. Whether you're dealing with brain fog, anxiety, or just want to perform at a higher level, these peptides could be worth exploring. Stacking Nootropics with Peptides One of the most popular strategies for cognitive support is to combine or stack peptides with nootropics. For example: Selank pairs well with L-theanine for calming, focused energy. L-theanine, an amino acid found primarily in green tea, promotes relaxation and reduces stress without causing drowsiness by increasing calming neurotransmitters like GABA and serotonin. Lion's Mane mushroom, a natural nootropic found in both wild and cultivated forms, can be stacked with Semax to naturally support memory, focus, and neurogenesis. Semax can be used with Alpha-GPC to support both short-term concentration and long-term brain health. Alpha-GPC (Alpha-glycerophosphocholine) is a choline-containing nutraceutical, often derived from soy or sunflower lecithin, that acts as a powerful nootropic. It increases levels of acetylcholine, a key neurotransmitter involved in learning, memory, focus, and muscle control. Because of its ability to cross the blood-brain barrier efficiently, Alpha-GPC is often used to enhance cognitive function, support brain health and neuroprotection, and improve physical performance by boosting power output and recovery in athletes. Semax can also be used with CDP-Choline for memory support, brain fog, and age-related cognitive decline. It too is a nutraceutical that provides choline, which the brain uses to produce acetylcholine, a neurotransmitter essential for memory, learning, and focus. It also delivers cytidine, which converts into uridine—a compound that supports neuron repair and brain cell membrane synthesis. Alright, so one question we get a lot is, “What's the difference between CDP-Choline and Alpha-GPC?” It's a good one—because they're both great choline sources, but they work a little differently. Alpha-GPC delivers choline more directly, which means you'll feel that boost in focus and mental energy a bit faster. It's especially handy if you're doing high-intensity brain work or even something athletic. Lastly, I also want to dive into something a lot of people are curious about, Modafinil and racetams (RASS-uh-tams). Modafinil (Provigil) is a prescription, stimulant medication used to treat sleep disorders (e.g., narcolepsy and obstructive sleep apnea) and shift work disorder. It's also used off-label as a focus-enhancing nootropic. It works by promoting wakefulness in the CNS. Researchers don't know exactly how it works, but it appears to affect areas in the brain that control attention and wakefulness. Racetams (e.g., Piracetam, Aniracetam, or Oxiracetam) are a class of compounds that enhance acetylcholine activity and neuroplasticity, leading to better learning, memory, and focus with subtle, non-stimulant effects. While Modafinil provides a noticeable surge in alertness and productivity, racetams offer a more gradual cognitive boost that can be ideal for sustained mental performance. Just remember, peptides provide foundational support—helping your brain repair and function better long-term. Nootropics can then layer on immediate effects, like sharper focus or improved mood. Thanks for listening to The Peptide Podcast. If you found this episode helpful, please follow or leave a review. And if there's a topic you'd like to hear more about, feel free to reach out—we'd love to hear from you. As always, have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.
In this episode of the Longevity Podcast, I sit down with my good friend and brilliant supplement formulator, Kyal Van Der Leest, who's known for his innovative work in the peptide space. Together, Kyal and I explore the fascinating world of brain health and uncover powerful strategies to boost cognitive function. What we discuss: Mold toxicity and health effects ... 00:03:49 Kyal's journey and Level Up Health ... 00:04:26 Lifestyle factors in brain health ... 00:19:19 Role of BDNF in neuroplasticity ... 00:24:44 Overview of neurotransmitters ... 00:30:12 Tessa Fensin and market withdrawal ... 00:39:01 Peptides for brain health ... 00:46:18 Blood flow and botanicals ... 00:53:06 Liposomal delivery benefits ... 01:06:22 Creatine for brain health ... 01:13:02 Kyal's supplement quality commitment ... 01:19:04 Conclusion and product info ... 01:26:00 Our Amazing Sponsors: Timeline: Mitopure is a breakthrough supplement that promotes cellular renewal. It contains Urolithin A, which helps your body clear out damaged mitochondria and create new, efficient ones—giving you more sustainable energy. Timeline is offering 10% off your order of Mitopure now. Go to timeline.com/NAT10. Wizard Sciences (Neural Rx) - isn't just about a quick boost. It's designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. It supports mitochondrial efficiency, for more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com. Young Goose L.A.D.R. Serum - Powered by light-activated DNA repair enzymes, NAD+, and collagen peptides, it reverses damage. Sunlight? Red light therapy? It all helps this serum work smarter, not harder. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. Future-proof your face. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
Dr. Tony Ebel interviews Dr. David Jockers, a renowned expert in functional nutrition. Dr. Jockers shares in-depth insights about the critical connection between blood sugar stability and nervous system health, particularly in children. Drawing from his personal experiences and extensive clinical work, he explains how proper nutrition can transform brain function, behavior, and overall wellbeing. The conversation covers practical strategies for parents to implement, from protein prioritization to hydration tips, and explores how modeling healthy behaviors creates lasting change for children. This episode provides actionable nutrition advice that can truly move the needle for families dealing with chronic health challenges.[00:06:00] Blood Sugar StabilityDr. Jockers identifies blood sugar stability as a major "needle mover" for healthPersonal story of growing up with blood sugar crashesWhy seed oils are problematic for cellular health[00:12:00] Protein Priorities for ChildrenGuidance on protein intake and why protein should be consumed first in a mealHow protein intake stabilizes blood sugar and prevents crashes[00:16:00] The Neuroscience of Blood SugarConnection between nervous system stability and blood sugar stabilityThe difference between hyperglycemia and reactive hypoglycemia in childrenHow hypoglycemic episodes damage neurons and increase risk of neurodegeneration[00:21:00] POTS Syndrome and Blood Sugar ConnectionDiscussion of how blood sugar instability contributes to POTS syndromeThe cascade effect: blood sugar instability → nervous system instability → hormonal instabilityDr. Ebel's clinical observations with teenage and young adult patients[00:25:00] Optimizing Brain Function Through NutritionHow stable blood sugar increases BDNF (Brain-Derived Neurotrophic Factor)Benefits of BDNF: creativity, innovation, better connections between neuronsPractical meal structure and "eating the rainbow" for phytonutrients[00:30:00] Hydration and Supplementation StrategiesThe importance of hydration timing (away from meals)Electrolytes and minerals: benefits for kids, especially active onesSupplements vs. food: "90% of health results come from lifestyle"Key supplements that make a difference: Magnesium, Vitamin D, K2[00:36:00] Modeling Health for ChildrenThe importance of parents demonstrating healthy behaviorsTeaching children nutritional concepts through benefit-focused languageConnect with Dr. Jockers: Website: www.drjockers.comInstagram: @drjockersYoutube: @drdavidjockers-- DETAILS & REGISTRATION FOR THE FREE MAY AUTISM SUMMIT Follow us on Socials: Instagram: @pxdocs Facebook: Dr. Tony Ebel & The PX Docs Network Youtube: The PX Docs For more information, visit PXDocs.com to read informative articles about the power of Neurologically-Focused Chiropractic Care. Find a PX Doc Office near me: PX DOCS DirectoryTo watch Dr. Tony's 30 min Perfect Storm Webinar: Click HereSubscribe, share, and stay tuned for more incredible episodes unpacking the power of Nervous System focused care for children!
Are you tired all the time? Energy is crucial to everything we do, from getting out of bed in the morning to getting work done throughout the day, and unfortunately it isn't as simple as just getting enough sleep. In this mini-episode, I'm giving you science-backed hacks you can use today to feel better tomorrow. As always, I don't recommend tackling all of these changes at once – instead, pick and choose a few changes that feel helpful to you, and build up from there. You deserve to feel present and reclaim your energy! 1:29 Meal Timing 3:36 Circadian Rhythm 6:27 Stress 9:14 Suppressing Emotions 13:14 Hydration 14:24 Movement 16:30 Busy, Not Productive 21:22 Task-Switching 23:51 Nagging To-Dos Ready to uplevel every part of your life? Order Liz's book 100 Ways to Change Your Life: The Science of Leveling Up Health, Happiness, Relationships & Success now! To join The Liz Moody Podcast Club Facebook group, go to www.facebook.com/groups/thelizmoodypodcast. Connect with Liz on Instagram @lizmoody or online at www.lizmoody.com. Subscribe to the substack by visiting https://lizmoody.substack.com/welcome. Check out these previous episodes of The Liz Moody Podcast mentioned in this episode: How To Work LESS AND Get MORE Done Top Attention Researcher: Our Attention Spans Are Down To 47 Seconds! Here's How To Fix It Neuroscience Hacks For Optimizing Dopamine, Serotonin, Oxytocin, BDNF, And More The Secret to Getting in Shape, Sleeping Better, Saving Money, And Being More Confident and Productive (Yes, Really!) with Dr. Katy Milkman New Circadian Science: Improve Your Energy, Metabolism, Focus, Strength, & More This episode is sponsored by: LMNT: go to DrinkLMNT.com/LizMoody to get a free LMNT sample pack with any order. Listen to Pulling The Thread with Elise Loehnen wherever you listen to podcasts, and check Elise out on Instagram @eliseloehnen. The Liz Moody Podcast cover art by Zack. The Liz Moody Podcast music by Alex Ruimy. Formerly the Healthier Together Podcast. This podcast and website represents the opinions of Liz Moody and her guests to the show. The content here should not be taken as medical advice. The content here is for information purposes only, and because each person is so unique, please consult your healthcare professional for any medical questions. The Liz Moody Podcast Episode 320. Learn more about your ad choices. Visit megaphone.fm/adchoices
SummaryIn this episode, of Metabolism, Muscles, and Mindset, Dr. Novitsky dives into one of her favorite topics as an obesity medicine doc and fitness enthusiast: the transformative link between exercise and energy. Listeners will gain insight into the bidirectional relationship between emotional and physical energy, the hormonal impacts of movement—including insulin sensitivity and cortisol regulation—and how exercise improves emotional regulation and stress resilience. She also touches on the importance of role models, confidence, and community, particularly for women, and how embodying strength becomes a purpose-driven, high-energy experience.She challenges the all-too-common belief that we're “too tired to exercise" and explores how breaking through that initial mental hurdle can unlock powerful benefits across physical, mental, and emotional energy systems.Exercise generates ATP, the body's basic energy currency, ramps up feel-good endorphins, and Brain-Derived Neurotrophic Factor (BDNF) - enhancing mood, cognition, and memory. Consistency in movement builds stamina and lowers the energy cost of exercise over time, making it easier and more enjoyable to stay active.Dr. Novitsky encourages everyone to find their “baseline minimum”—the small, sustainable commitment to movement that keeps energy and confidence high, without burnout.Key Points• Breaking the Mindset Barrier: Exercise can feel tiring before it's energizing—but getting started is the key to unlocking its benefits.• Energy on All Levels: Movement elevates physical, emotional, and mental energy by producing ATP, endorphins, and BDNF.• Stamina Through Consistency: The more conditioned you are, the less energy it takes to move—and the more mental energy you free up.• Sleep & Timing: Exercise can improve sleep quality, depending on timing and intensity. Emotional regulation through movement sets the stage for restful nights.• Hormone Harmony: Strength training boosts insulin sensitivity and regulates key hormones like cortisol, leptin, and ghrelin for steady energy.• Emotional Regulation: Exercise fosters better thoughts by creating a calm, grounded state—reducing spirals and buffering behaviors.• Confidence & Purpose: Strength training enhances confidence, especially for women, and becomes a powerful tool for embodying purpose.• The Power of Community: Supportive environments elevate both energy and belief in what our bodies can achieve.Timestamps• 00:02 – The exercise-energy paradox: feeling too tired to move• 01:35 – How ATP and endorphins fuel physical and emotional energy• 02:20 – Why morning workouts set the tone for your day• 03:30 – BDNF and mental clarity: your brain's “topsoil”• 04:45 – The interconnected nature of physical, emotional, and mental energy• 06:00 – Exercise timing and its effect on sleep and emotional regulation• 07:11 – Bringing a “vacation mindset” to everyday life• 08:10 – Building stamina: why conditioning makes movement easier• 09:30 – Mental energy saved through physical conditioning• 10:45 – Emotional regulation through movement: less stress, better thoughts• 11:50 – Exercise, insulin sensitivity, and avoiding post-meal energy crashes• 13:30 – Hormonal impacts: cortisol, leptin, and ghrelin• 14:15 – Strength as confidence: how exercise becomes empowerment• 15:45 – Role models and community: elevating female strength• 16:30 – Finding your baseline minimum: the smallest step for maximum energyFollow Dr. Ali Novitsky on SocialsTikTok• Facebook• Instagram• YouTubeWork with Dr. Ali• Beginner Strength Training Program – 12 months for only $199! Enroll TODAY• Transform® 9.0 – Enrollment now open! Starts May 5th. Learn more HERE• Total Fitness Program – A 12-month mind-body experience. Enroll HERE• Nutrition Training Program (48-CME) is enrolling now! Get the details HERE.• The Fit Collective® x InBody USA/Canada – Get 15% off select models. Click HERE
Biohacking for Longevity: Extending Your Health Span. In this episode of "Leyla Weighs In," registered dietician and nutritionist Leyla Muedin discusses the concept of biohacking and its potential to extend lifespan and health span. Leyla explores various biohacking strategies such as diet optimization, regular physical activity, stress management, enhancing sleep quality, and maintaining strong social connections. She emphasizes the importance of epigenetics, targeted lifestyle changes, and advanced medical interventions like stem cell therapy. You will learn practical biohacking tips, including the benefits of intermittent fasting, the significance of exercise, and how to use wearable technology for health tracking. Leyla also highlights the role of supplements and personalized nutrition in promoting longevity, alongside maintaining good dental health and a sense of purpose. Through these combined efforts, Leyla aims to inspire listeners to not only live longer lives but to enjoy better health and vitality.
Story at-a-glance Butyrate, produced by gut bacteria when they ferment dietary fiber, acts as a signaling molecule in the gut-brain axis, influencing stress, pain tolerance, immunity and brain health Through multiple mechanisms, including specific enzyme inhibition and NF-κB pathway regulation, butyrate reduces neuroinflammation and protects against neurodegenerative conditions like Alzheimer's and Parkinson's disease Butyrate influences key neurotransmitters including GABA, serotonin and dopamine, while also increasing brain-derived neurotrophic factor (BDNF), which supports neuronal growth and cognitive function The vagus nerve serves as a communication highway between the gut and the brain, transmitting signals about butyrate levels that affect mood regulation, stress response and immune function Optimizing gut health through dietary fiber and homemade fermented foods helps promote butyrate production and maintain a healthy gut-brain connection
Want to sharpen your focus, build unbreakable discipline, and tap into peak mental performance? In this episode, we break down how fasting rewires your brain for productivity, boosts BDNF for sharper thinking, and trains your willpower like a Navy SEAL. Hear how Jack Dorsey, Georges St-Pierre, and monks use fasting to gain an edge—and learn how you can do the same. Plus, get a simple fasting protocol to unlock mental clarity and self-control starting today!
In this episode of the Metabolic Freedom Podcast, we dive deep into the science of fasting and what happens inside your body during a 36-hour fast. From lowering insulin and tapping into fat-burning mode, to activating autophagy (cellular cleanup) and boosting brain-derived neurotrophic factor (BDNF), this fasting timeline unlocks powerful metabolic benefits. We explore: ✅ The first 14 hours: Lower insulin, burn glycogen, and experience energy diversion. ✅ 16-hour mark: Autophagy kicks in, clearing out damaged cells and enhancing fat burning. ✅ 24-hour mark: Digestive system reset with an intestinal stem cell reboot. ✅ 30-hour mark: BDNF production surges, improving brain function and mental clarity. ✅ 36-hour mark: Significant fat loss, increased ketone production, and a metabolic reset. Ben answers common fasting questions, including muscle loss concerns, what to drink, exercise during fasting, and the best way to break a 36-hour fast. Plus, hear about the longest fast ever recorded!
The brain undergoes a major change during weight loss. The result often is a much happier person with less depression. But the reason why this is happening goes far beyond just enjoying a smaller waist and what you see in the mirror. There are substantial chemical changes occurring in the brain that alleviate depression, improve mood, and bolster mental health. Dr. Hana Kahleova explores the science behind the brain boosting benefits of weight loss when she joins Chuck Carroll on The Exam Room Podcast. — In This Interview — - Bi-directional relationship between obesity and depression. - High-carb diets more beneficial than keto diets for mental health. - Fat quality, carbohydrates, fiber, and flavonoids are important. - BDNF (brain-derived neurotrophic factor) plays a crucial role in mood regulation. — — SHOW LINKS — — Watch - Weight Loss and the Brainhttps://www.youtube.com/watch?v=1RBUCWA2IJI — — EVENTS — — Lotus Health Summit Where: Rochester, MN (DATES) When: April 17-18, 2025 Who: Dr. Neal Barnard, Brenda Davis, Chuck Carroll Tickets: https://www.lotushealthfoundation.org/2025-symposium-and-gala — — BECOME AN EXAM ROOM VIP — — https://www.pcrm.org/examroomvip — — THIS IS US — — The Exam Room Podcast Instagram: https://www.instagram.com/theexamroompodcast — — — Chuck Carroll Instagram: https://www.instagram.com/ChuckCarrollWLC Facebook: http://wghtloss.cc/ChuckFacebook X: https://www.twitter.com/ChuckCarrollWLC — — — Physicians Committee Instagram: https://www.instagram.com/physicianscommittee Facebook: https://www.facebook.com/PCRM.org X: https://www.twitter.com/pcrm YouTube: https://www.youtube.com/user/PCRM Jobs: https://www.pcrm.org/careers — — SUBSCRIBE & SHARE — — 5-Star Success: Share Your Story Apple: https://apple.co/2JXBkpy Spotify: https://spoti.fi/2pMLoY3 Please subscribe and give the show a 5-star rating on Apple Podcasts, Spotify, or many other podcast providers. Don't forget to share it with a friend for inspiration!
Episode Highlights With Dr. Erika GrayImportant perspective about genetics and how to use this information for the biggest advantageThe nuance when it comes to children and genes Genes do not exist in isolation and why focusing on one gene is not helpfulHow understanding genetics helped her teens (and mine)What COMT is and how this comes into play with influencing our worldviewFast COMT break down dopamine and norepinephrine faster (linked to moving around, not sitting still, etc.)How this understanding of genetics can relate directly to how we parent Yet another reason protein is so important, especially for kids and teens Genes related to serotonin and dopamine and neurotransmittersWe have 2-5 lbs of bacteria in our gut, and there is a gene called FUT2 that ties to lower levels of bifidobacteria, and this can be linked to anxiety, longevity, and moreUnderstanding choline genes and why this is a game changer for so many people, and this is critical for pregnancy and brain development Some caveat around MTHFR and why we might be overdoing our response to thisSerotonin-related genes to look at if you get your kids' genes testedWhat BDNF genes can tell youMC4R is a snacking gene, and how to understand thisBitter taste receptor genes and how these can make kids more pickyResources We MentionMy Toolbox Genomics - Use code wellnessmama for a discountKion Aminos
In this episode, I discuss how different forms of exercise impact brain health and performance in both the short and long term. I explain how many of the positive effects of exercise on brain function occur through the action of specific neurochemicals that increase alertness. I also cover how to best time exercise and which specific types of exercise to include in your weekly routine to maximize benefits for your brain. Additionally, I explain how certain types of exercise trigger the release of a hormone from your bones called osteocalcin, as well as brain-derived neurotrophic factor. Together, these substances increase neuroplasticity and enhance learning. The positive effects of exercise on brain oxygenation, blood supply, and fuel utilization are also discussed. Listeners will learn how to design a weekly exercise program that optimizes physical fitness, brain health, longevity, and performance, along with the mechanistic logic behind those recommendations. Find show notes with articles, resources and more at hubermanlab.com. Pre-order Andrew's upcoming book, Protocols: https://go.hubermanlab.com/protocols Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman David: https://davidprotein.com/huberman Function: https://functionhealth.com/huberman Maui Nui: https://mauinui.com/huberman Timestamps 00:00:00 Exercise, Brain Health & Performance; Protocols Book 00:04:03 Sponsors: BetterHelp & Helix Sleep 00:06:55 Brain Health, Cardiovascular & Resistance Training 00:11:51 Exercise & Positive Impact on Brain Performance; Arousal 00:18:20 Learning & Arousal 00:23:18 Sponsors: AG1 & David 00:26:01 Exercise & Acute Learning 00:29:16 Tool: High-Intensity Training & Cognitive Flexibility; Over-Training 00:33:32 Long-Term Brain Health; Tool: Exercise “Snacks”, Cognitive Performance 00:36:57 Exercise, Brain & Body Energy, Adrenaline, Norepinephrine 00:44:08 Adrenal “Burnout”?; Exercise to Increase Energy, Adrenaline 00:48:20 Tool: Core, Compound Movements; Mind-Body Connection 00:53:58 Sponsor: Function 00:55:45 Bones, Osteocalcin, BDNF & Hippocampus; Tool: Jump Training 01:01:30 Exercise, Fuel, Multifactorial Pathways; BDNF & Activity 01:05:06 Lactate, Astrocytes & Brain Function; VEGF & Brain Health 01:11:17 Tools: Zone 2, High-Intensity Training, Time Under Tension Training 01:19:54 Sponsor: Maui Nui 01:21:37 Tools: Time Under Tension; Explosive Jumping, Eccentric Control Training 01:25:30 Injury & Exercise, Illness 01:28:09 Sleep; Injury, Sleep-Deprivation & Exercise 01:33:51 SuperAgers, Anterior Mid-Cingulate Cortex, Grit & Persistence 01:42:04 Tool: Embrace Challenges; Deliberate Cold Exposure, Rope Flow 01:47:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
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