Podcasts about bdnf

An increase of just 40 watts of leg power is linked to cognitive aging benefits equivalent to a brain functioning three years younger. There's also a direct relationship between leg strength and the size of your hippocampus — the memory center of your brain, and one of the first regions affected by Alzheimer's.In the final episode of Move for Your Brain, Amy and Marian Barnick bring it all together: the research on leg strength and brain health, Marian's Foundations First framework applied specifically to lower body strength, and Marian's own long recovery road — multiple surgeries, two total knee replacements, and what she learned going through it all as both the expert and the patient.This is the episode to share with every woman in your life who thinks she's too broken, too busy, or too late to build strong legs. She's not. Do not settle.What You'll LearnThe King's College London twin study: what 10 years of data says about leg strength and brain healthWhy your hippocampus — your memory center — is directly linked to how strong your legs areWhat happens to proprioception after a knee replacement, and what retraining really looks likeHow to apply Foundations First to lower body strength: ankles → hips → balance → strengthWhy pain is the number one thing that stops women from building the strength their brains needThe difference between "used to be athletes" and "forever athletes"Marian's mantra — do not settle — and Amy's reframe: it's your future self, not your old selfWhat to Listen For[1:11]  Amy's opening — leg strength and the brain[2:29]  Marian's recovery road: the car accident, surgeries, what she didn't expect[5:22]  Leg strength and hippocampal volume: the research[6:19]  Foundations First applied to lower body strength[8:35]  "Your ankle mobility shows up as knee pain" — finding the root cause[11:55]  Pain is the #1 barrier — BDNF and why movement helps[12:39]  Marian's free lower body mobility guide[17:01]  Marian's pet peeve: why "just get stronger" is incomplete advice[20:16]  Forever athletes vs. used to be athletes[20:49]  Tennis as a brain health activity[23:26]  Leg strength as locomotion and independence[24:10]  "Do not settle" — Marian's mantra[27:41]  Amy's reframe: future self, not old self[31:24]  The stair moment: small wins, big winsResources MentionedKing's College London twin study on leg power and cognitive aging: https://pmc.ncbi.nlm.nih.gov/articles/PMC4789972/RESTORED Protocol (free guide): moxie-club.com/restoredIs It Just Brain Fog? Quiz: moxie-club.com/bfquizMarian Barnick's free lower body mobility guide: MarianBarnick.com/GuideRESOURCES:Book a FREE Discovery Call with AmyOrder Amy's book Thoughts Are Habits Too:  Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating.Schedule your Breakthrough Roadmap session with AmyFollow Amy on Instagram @amylangcoaching Follow Amy on Facebook @amylangcoachingSubscribe to Amy's YouTube channel @happyandhealthywithamy

In this first part of what became a two-part conversation, we sat down with anesthesia provider Charles Miller from Scenic City Neurotherapy for a discussion that challenged so many assumptions about ketamine therapy.Charles presents what he calls the "collective lie" in ketamine therapy - the argument that the obsession with psychedelic experiences and mystical insights for a growing segment of providers in our industry is not just misguided, but actually making our patients worse. He walks through the neurobiological evidence showing that the real therapeutic action happens days after treatment during the neuroplasticity window, not during those profound moments when patients feel like they're talking to God or having life-changing realizations.You'll hear Charles critique the research methodologies that seem to support ketamine-assisted psychotherapy, explaining why group averages can mask poor individual outcomes and why the frequently cited KAP studies may actually show lower success rates than standard ketamine protocols. He also shares refreshingly honest advice about starting a clinic - including his decision to open with folding chairs rather than go into debt for impressive furniture.We're also trying something new with this episode: audio sidebars. As we talk, we'll pause to provide additional context about complex concepts like psychoplastogens, research study limitations, and the cutting-edge science behind separating therapeutic effects from psychedelic experiences. Think of these as educational moments designed to help you fully understand and enjoy the episode.This conversation will make you question whether the approaches many of us have been using actually serve our patients - or if we've been chasing the wrong mechanisms entirely.What You'll Learn in This Episode· Charles's entrepreneurial journey - How he started Scenic City Neurotherapy with minimal capital and his advice for keeping overhead low during startup· The "collective lie" concept - Why Charles believes the field's emphasis on ketamine experiences actually reduces treatment success rates· Neuroplasticity mechanisms - Detailed explanation of the NMDA-glutamate-BDNF pathway and why the therapeutic window occurs after, not during, ketamine administration· Psychoplastogens vs psychedelics - Understanding David E. Olson's groundbreaking research on compounds that promote neuroplasticity without hallucinogenic effects· Research methodology critique - Analysis of popular KAP studies and why methodological flaws may be masking poor individual patient outcomes· Evidence-based positioning - How to counter the "ketamine is just anesthesia" criticism with solid neurobiological science· Experience vs neuroplasticity - Why Charles argues that focusing on insights and visions during treatment may be counterproductiveKey Takeaways· Ketamine may function primarily as a psychoplastogen rather than a classic psychedelic, blocking NMDA receptors to trigger neuroplasticity cascades instead of flooding serotonin receptors like traditional psychedelics· The therapeutic neuroplasticity window occur days to weeks after ketamine administration, when BDNF-driven synaptic remodeling takes place, not necessarily during the acute dissociative experience· Research comparing ketamine-assisted psychotherapy to standard protocols could show mixed results, with some studies reporting lower individual response rates despite promising group averages· Providers who overfocus on experiential components during treatment may inadvertently create performance pressure that could reduce patient outcomes and increase perceived treatment failure rates· Startup ketamine clinics might benefit from beginning embarrassingly small with minimal overhead, focusing resources on essential clinical equipment rather than impressive lobbies or furniture· David E. Olson's psychoplastogen research suggests that neuroplastic benefits might be separable from psychedelic experiences, supporting approaches that prioritize physiological mechanisms over experiential componentsEpisode 52 show notes:00:00:00 - Teaser: When Patients Feel They Failed00:00:17 - Introduction and Episode Setup00:02:06 - Charles's Journey into Ketamine Therapy00:04:30 - The Entrepreneurial Leap00:06:00 - Startup Advice: Think Embarrassingly Small00:08:30 - Evolution of the Ketamine Field00:10:00 - The "Collective Lie" Concept Introduction00:12:30 - Neurobiological Mechanisms00:16:30 - Psychoplastogens vs. Psychedelics00:24:00 - David E. Olson's Revolutionary Research00:27:27 - Audio Sidebar: Psychoplastogens & David E. Olson00:30:00 - Research Critique: KAP Study vs Real-World IV Ketamine Data00:34:27 - Episode Wrap-upThanks for listening

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Modern neuroscience confirms something our bodies already know: the brain was designed to move. Physical activity stimulates brain-derived neurotrophic factor (BDNF), improves neuroplasticity, protects the hippocampus, and reduces the risk of cognitive decline. As a neurologist and chiropractor, I see the consequences of inactivity every day—degeneration of joints, loss of balance, neurological slowing, and early dependence on others for basic life functions. The truth is simple: movement is medicine for both the brain and the body.That is why I say, “I'd rather be the oldest person in the gym than the youngest person in the nursing home.” Exercise is not about vanity or appearance—it is about independence. Strength preserves dignity, balance prevents falls, and physical challenge keeps the nervous system alive and adaptable. The gym is not a punishment; it is a commitment to your future self. Train today so that decades from now you can still walk, move, think clearly, and live life on your own terms.Dr. Fred Clary, founder of Functional Analysis Chiropractic Technique and lifting/life coach/ gym-chalk covered philosopher talks about aging well.

Register for a live Q&A with Dr. Tommy Wood on Wednesday, March 25th.Decreased glucose uptake in the brain is often considered a hallmark of Alzheimer's disease. But Dr. Tommy Wood asks whether part of that metabolic signature may reflect how little cognitive demand we place on the brain.He sits down with Dr. Dominic D'Agostino for a nuanced conversation on metabolic health and cognitive function.. Dr. Wood is a neuroscientist, neonatal brain injury researcher, and author of The Stimulated Mind.This episode follows the metabolic thread through every stage of brain health. Pre-diabetes and type 2 diabetes as predictors of cognitive decline. Neurovascular coupling as the reason heart disease risk factors double as brain disease risk factors. Lactate crossing the blood-brain barrier to drive BDNF production where it actually matters. Creatine as a brain energy distributor that most people still only associate with muscle. Dr. Wood lays out his Three S Model — Stimulus, Supply, Support — and makes the case that cognitive demand drives glucose uptake into the brain the same way muscular contraction drives it into skeletal muscle.Questions Answered in This Episode:Does the brain respond to energy demand the same way skeletal muscle does?What role does creatine play in brain energy distribution, and what do the clinical trials show?Can heavy resistance training produce the same brain-relevant lactate response as HIIT?How should exercise be dosed after a concussion or traumatic brain injury?Is cognitive decline in your 50s, 60s, and 70s actually inevitable, or is that a statistical artifact?Why are pre-diabetes and metabolic syndrome among the strongest predictors of dementia?The mechanistic throughline here is demand-driven metabolism. Dr. Wood makes the case that the same principles governing glucose uptake in skeletal muscle apply to the brain — and the conversation gets into what that means for how we interpret FDG-PET data, design lifestyle interventions, and think about neurodegeneration itself.Find more at DrTommyWood.comSpecial thanks to the sponsors of this episode:✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK here✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here✅ Toups and Co – Get 15% off your first order with code METABOLIC here✅ ZocDoc - Find and instantly book a top-rated doctor hereIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Send a textIn this episode, Dr. Porter breaks down the neuroscience behind why your brain is not built for modern life — and what to do about it. From the glymphatic system that washes your brain during sleep, to the voltage drop that leads to dementia, to the 2 PM cortisol trough that kills your afternoon — this conversation will change how you think about your brain forever.​In this conversation, you'll learn:◼️ Why your brain shrinks ¾ inch overnight◼️ How drinking coffee before 10 AM shuts down your dopamine and cortisol production◼️ The "glymphatic system" discovery: how deep sleep literally washes your brain clean◼️ Brain voltage explained: 18.1V at birth → below 7V = dementia → below 4V = Alzheimer's◼️ The Google/Microsoft study where a 20-min BrainTap session at 2 PM boosted output by 26%◼️ Why "grind culture" is neuroscience backwards — and what high performers actually do◼️ His dad's alcoholism origin story and how it led to the Silva Method breakthrough◼️ BDNF: the "Miracle-Gro for the brain" you trigger 10 minutes after exercise◼️ MIT's discovery that your body absorbs light codes from distant star systems — run through DNA◼️ The heart transplant patient who started craving KFC — and what it proves about cellular memory◼️ Alarm clocks, melatonin timing, and the liver-cleaning window between 11 PM–12 AM◼️ Why stressed mice outlived comfortable ones (and what that means for your daily habits)◼️ The "pause, break, breathe" technique that Einstein and top performers use before answering​

View This Week's Show NotesStart Your 7-Day Trial to Mobility CoachJoin Our Free Weekly Newsletter: The AmbushWhat if the biggest predictor of dementia isn't your genes — but your metabolic health?In this episode, neuroscientist and performance coach Dr. Tommy Wood reveals why blood sugar regulation and blood pressure are more powerful predictors of Alzheimer's disease and cognitive decline than amyloid plaques or even genetics like ApoE4.For decades, Alzheimer's has been framed as either a genetic lottery or the inevitable buildup of amyloid in the brain. But emerging research shows that metabolic dysfunction, insulin resistance, and vascular health may play a far greater role in determining long-term brain outcomes.Instead of focusing on fear, this conversation delivers a practical blueprint for building cognitive reserve and “cognitive headroom” — the brain's ability to stay resilient, adaptable, and high-performing as you age.You'll learn why crossword puzzles aren't enough, how high-intensity exercise and resistance training stimulate brain-derived neurotrophic factors (BDNF), why lactate may act like “Miracle-Gro” for your neurons, and how to interpret early warning signs like subjective brain fog.What You'll Learn in This EpisodeWhy Alzheimer's isn't just about amyloid plaquesThe powerful link between blood sugar and cognitive declineHow genetics (like ApoE4) increase risk — but don't seal your fateWhat “cognitive headroom” means and how to build itWhy high-intensity exercise may act as Miracle-Gro for the brainThe surprising role of resistance training in brain healthWhat subjective brain fog might be telling youHow menopause affects cognition — and what's reversibleWhy boredom and focus matter more than we thinkThe kinds of skills you should keep practicing as you ageFor women navigating perimenopause and menopause, Dr. Wood explains what cognitive changes are hormonally driven, what's reversible, and how to protect long-term brain health.Whether your goal is preventing Alzheimer's disease, improving focus and processing speed, or becoming a cognitive “superager,” this episode provides evidence-based strategies to help you build a brain that is robust, metabolically healthy, and built to last.Key Highlights: (00:00) – Brain Health & Cognitive Longevity Intro(00:35) – Brain Evolution & Survival Mechanisms(02:53) – Diabetes & Alzheimer's Disease Link(07:31) – Genetic Risk & Dementia Family History(11:32) – Expanding Brain Capacity & Headroom(15:08) – Cognitive Reserve & Brain Resilience(19:55) – Preventing Age-Related Cognitive Decline(23:00) – Exercise Data for Brain Health(26:16) – Best Exercises for Cognitive Function(35:11) – Amyloid Plaques & Alzheimer's Pathology(38:00) – Amyloid-Targeting Drugs & Treatments(40:31) – Subjective Cognitive Decline Measures(45:04) – Testing & Measuring Brain Performance(49:58) – Menopause & Female Brain Health(56:10) – Aging Brain, Wisdom & Intelligence(1:05:00) – Cognitive Processing Speed & Aging(1:07:07) – Benefits of Boredom for the Brain(1:12:17) – Book Recommendations for Mental GrowthConnect with Dr. Tommy WoodWebsite | Substack | InstagramPre-Order The Stimulated Mind for tons of extra perks!Huge thanks to our sponsors, Momentous, Vitality, and LMNT.

 Whether you feel stuck in your career, your relationship, your friendships, your habits, your overall life, it can feel hopeless. It can feel confusing. It can feel really, really frustrating. In my over 400 conversations with experts on this podcast, the topic of feeling stuck or how to make the right decision or how to get out of a slump comes up so, so often. So I decided to put together the ultimate unstuck toolkit, which covers everything you need from all angles (neuroscience, behavioral patterns, relationship patterns) to help you gain motivation, clarity, and finally feel like you are able to move forward.

Can something as simple as walking or running rival antidepressants? In this episode of The Lebanese Physicians Podcast, I sit down with Dr. Farid Talih, American board–certified psychiatrist, sleep medicine and addiction specialist, to explore the powerful science behind exercise as a treatment for depression and anxiety. We dive into: How exercise reshapes the brain through BDNF (brain-derived neurotrophic factor) Why movement works differently than SSRIs and psychotherapy The role of lactate, cortisol, endorphins, and the “runner's high” Exercise vs medication: when to use one, the other, or both Group exercise, loneliness, and mental health Practical, realistic ways to “prescribe” movement in real-world settings Cultural, socioeconomic, and access barriers to exercise Exercise in pregnancy, postpartum depression, aging, and addiction recovery Why mental health care must stay individualized, humane, and holistic This episode challenges the idea that mental health treatment is only about prescriptions and reminds us that movement, connection, and context matter.

Have you ever noticed how quickly your mood can shift… and then blamed yourself for it? Like you should just think more positively or try harder to control your mindset? In this week's episode of The Thin Thinking Podcast, I'm joined by Jenn Trepeck for a conversation that many of you will find incredibly freeing:

Jejum intermitente não é só para emagrecer. Neste episódio do Made in Brasil, a Dra. Maíra Soliani explica, com base científica, como o jejum intermitente pode melhorar clareza mental, foco e produtividade, além de apoiar saúde metabólica e longevidade.

Vitamin D testing is vital for tailoring doses to optimize health—but regulators are conducting a campaign to deny coverage; Can magnesium be taken simultaneously with blood pressure meds? Lifelong learning delays Alzheimer's onset by 5 years; Your MRI says you have a bum shoulder—but 99% of people show abnormalities even when they have no discomfort; Saunas can help stave off dementia. 

VO2 max is one of the strongest, most measurable predictors we have of longevity; and for midlife women, getting your cardio strategy right matters. In this episode, I break down the real truth behind the “HIIT vs Zone 2” debate, and show you how to use both in a way that supports energy, brain health, and long-term performance, including what Zone 2 training really improves, and what HIIT actually changes in your body. You'll also learn how to programme cardio in midlife so you increase VO2 max without disrupting sleep, strength training, or your ability to recover. By the end, you'll have a clear weekly framework to build cardiovascular fitness safely in midlife, even if you're time-crunched, plus two science-backed interval workouts that reliably improve VO2 max. WHAT YOU'LL LEARN • Why VO2 max is a powerful longevity marker (and why it matters in midlife) • The difference between Zone 2 and HIIT (and what each one is for) • What Zone 2 builds (aerobic base, mitochondria, recovery capacity) • Why Zone 2 often “feels pointless” for high-achieving women (and what to do instead) • How HIIT improves VO2 max, insulin sensitivity, and metabolic health • The brain benefits of Zone 2 vs Zone 5 (BDNF, lactate, blood flow) • Why “more intensity” often backfires in midlife (sleep, stress, injury risk) • The progression hierarchy that protects your joints and results• How many HIIT sessions women actually need (and when it's too much) • Two evidence-backed HIIT workouts: micro-intervals + the Norwegian 4x4 • A simple weekly template that works even with 30 minutes a day • How to combine resistance training + cardio in the same day for best results VALUABLE RESOURCES 10 Habits That Help Me Reverse My Biological Age (Free Guide)

In this episode, I sit down with neuroscientist Dr. Louisa Nicola to unpack what women actually need to know about Alzheimer's risk, cognitive decline, and long term brain protection. We break down APOE genetics, advanced blood biomarkers that can now detect amyloid and tau with remarkable accuracy, and why brain health is inseparable from metabolic health. Louisa explains how muscle acts as a metabolic sink for glucose, why resistance training and high intensity intervals stimulate BDNF, and how sleep drives the glymphatic system to clear amyloid from the brain. If you want practical tools to assess your personal risk, understand your labs, and build a proactive prevention plan decades before symptoms appear, this conversation is for you. → Leave Us A Voice Message!  Topics Discussed: → What does APOE4 mean for Alzheimer's risk? → Can exercise prevent cognitive decline? → Do blood tests detect early Alzheimer's? → How does perimenopause affect brain health? → Does hormone therapy reduce dementia risk? Sponsored By:  → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/KELLY and save up to 39% off your Mitopure® Gummies. → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com. → Cozy Earth |  Head to https://cozyearth.com and use code BEWELL for up to 20% off. And if you get a post-purchase survey, make sure you tell them you heard about Cozy Earth right here at the Be Well by Kelly podcast.  → LMNT | Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at https://drinklmnt.com/Kelly. Find your favorite LMNT flavor, or share with a friend. Timestamps:  → 00:00:00 - Introduction → 00:01:27 - Mission to end Alzheimer's  → 00:03:28 - Women's rate of Alzheimer's  → 00:04:11 - Alzheimer's overview  → 00:07:44 - Education level & health  → 00:09:57 - Anatomy  → 00:14:16 - Neuroplasticity & glucose  → 00:19:38 - Amyloid-beta → 00:26:41 - LDL Cholesterol → 00:28:36 - Preparing for menopause  → 00:31:30 - Blood testing recommendations  → 00:34:26 - Lifestyle interventions  → 00:39:05 - Nutrition & the MIND diet  → 00:42:19 - Zone 2 vs zone 5 training  → 00:44:36 - Lactic acid  → 00:47:58 - HRT is protective → 00:50:19 - When to test for HRT → 00:51:56 - Testosterone + brain health  → 00:53:40 - Cognitive reserve  → 00:57:12 - Hot flashes  → 00:58:13 - Quick fixes  → 01:00:01 - Brain surgery  → 01:05:38 - The brain code  Show Links: → Function | Own your health for $365 a year. That's a dollar a day. Learn more and join using my link. Visit https://www.functionhealth.com/bewellbykelly and use gift code BEWELL25 for a $25 credit toward your membership Further Listening: → How to Take Control of Your Health in a Toxic Food Landscape | Max Lugavere  Check Out Louisa:  → Instagram  → The Brain Code Check Out Kelly: → Instagram → Youtube → Facebook

Think your brain has to slow down with age? We push back hard with science, stories, and a step-by-step plan that has helped patients regain clarity in weeks, not years. Our guest, Dr Majid Fotuhi, a Harvard- and Hopkins-trained neurologist who has treated thousands of patients, explains why common forgetfulness isn't the same as cognitive decline and how simple daily choices can restore sharpness at any age.We break brain health down to four core levers: increase blood flow, reduce inflammation, enhance the brain's cleaning systems, and minimize plaques and tangles. Then we map those levers to five daily pillars you can actually do: exercise, sleep, nutrition, stress reduction, and learning. You'll hear why exercise is the highest-yield habit for cognition, how BDNF acts like fertilizer for the hippocampus, and what happens when sugar spikes and insulin resistance quietly shrink your memory center. We also get practical about sustainable nutrition, from curbing glucose swings to deciding whether keto is worth it for your lifestyle.Beyond biology, we dig into the mindsets that keep the brain young. Boredom—of the unplugged, daydreaming kind—can unlock creativity and problem solving. A clear sense of purpose measurably lowers dementia and stroke risk while making healthy choices easier to keep. We share the telltale red flags (like repeating questions) versus normal lapses (like misplacing keys), plus the personalized assessment approach that uncovered treatable factors in patients who feared Alzheimer's. If you want a realistic timeline, expect noticeable gains in about 12 weeks when you dial in the five pillars.Ready to build a resilient, younger brain? Follow the five pillars, personalize your plan, and start today with one small step—take a brisk walk, protect your sleep window, or learn something challenging you actually enjoy. If this conversation helped you, tap follow, share it with a friend who needs hope, and leave a quick review so more people can find it.https://drfotuhi.com/Continue this conversation on SubStack: https://robertlufkinmd.substack.com Get 120 Biomarkers for $99 and CT Calcium scans anywhere in the US. https://www.vitalsvault.com/ Win a Signed Copy of Lies I Taught in Medical School :https://robert-lufkin.mykajabi.com/pages/review-kit Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: https://www.facebook.com/robertlufkinmd ...

Get AudioBooks for FreeBest Self-improvement MotivationA Simple Way to Boost BDNF for Brain PowerLearn a simple, science-backed way to increase BDNF and support brain growth, memory, and focus. Boost mental performance and long-term brain health.Get AudioBooks for Free⁠We Need Your Love & Support ❤️https://buymeacoffee.com/myinspiration#Motivational_Speech#motivation #inspirational_quotes #motivationalspeech Get AudioBooks for Free Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Your self-image shapes your decisions, your perspective and your outcomes. And because your self-image is formed from a very young age, it can be difficult to change the habits, thoughts, and patterns that have been ingrained for decades. Today, you're going to learn a proven framework for improving your self-image and overcoming self-doubt.   On this episode of The Model Health Show, our guest is behavioral researcher and educator, Dr. Shadé Zahrai. She's here to share science-backed strategies for shaping your self-image from her new book, Big Trust. You're going to discover how to rewire self-doubt, how to build confidence, and how transforming your self-image can help you reach your potential.   Specifically, we're going to discuss the four inner attributes that could be holding you back, and how to sharpen them to improve your self-esteem, mindset, and overall personal growth. Dr. Shadé is an absolute expert in helping folks break free from the mindset blocks that are holding them back. If you're ready to take control of your inner world so you can improve your relationships, decision making, and more, this episode is for you. Enjoy!    In this episode you'll discover:  The connection between confidence and well-being. (3:29)  Why you need to take action to develop confidence. (3:49)  What self-image is. (8:21)  The truth about changing your personality. (10:58)  What the most common self-doubt is, and where it originates from. (13:10)   Four main signs that you struggle with self-acceptance. (15:51)  How having a creative hobby can help improve your self-esteem. (18:57)  The power in simply delaying a decision. (29:51)   What imposter syndrome is and how to reframe it. (37:26)  How pursuing discomfort can activate BDNF. (43:18)  Why comparison can be a sign that you struggle with agency. (47:31)  What autonomy is and how it relates to self-doubt. (59:13)  How microdosing hard things can get you out of your comfort zone. (1:05:05)   Signs you might be struggling with adaptability. (1:15:37) Items mentioned in this episode include:  Organifi.com/Model - Use the coupon code MODEL for 20% off + free shipping!  DrinkLMNT.com/model -  Get a FREE sample pack of electrolytes with any order!  Big Trust by Dr. Shadé Zahrai - Order your copy of the book today!   The Doubt Profille - Discover your doubt profile & what it's costing you!    Connect with Dr. Shadé Zahrai Website / Instagram / Facebook / YouTube     Be sure you are subscribed to this podcast to automatically receive your episodes:   Apple Podcasts  Spotify  Soundcloud  Pandora  YouTube     This episode of The Model Health Show is brought to you by Organifi and LMNT.   Organifi makes nutrition easy and delicious for everyone. Take 20% off your order with the code MODEL at organifi.com/model.  Head to DrinkLMNT.com/model to claim a FREE sample pack of electrolytes with any purchase. 

Une mémoire n'est jamais qu'un simple fichier dans le cerveau, c'est un fil qui nous relie à ce que nous sommes. Nous ouvrons l'épisode avec des récits sincères tirés de l'expérience de notre propre famille avec la maladie d'Alzheimer, ainsi que du poids silencieux porté par les proches aidants, puis nous passons à ce que la science nous dit aujourd'hui pour protéger l'esprit de demain. L'objectif n'est ni la perfection ni la peur, mais une prévention pratique, ancrée dans la vraie vie.Nous expliquons la différence entre la maladie d'Alzheimer et les autres formes de démence, pourquoi l'espérance de vie moyenne après le diagnostic se situe souvent entre 7 et 10 ans, et comment les habitudes adoptées tôt peuvent bâtir une réserve cognitive. L'activité physique occupe une place centrale : l'exercice régulier augmente le BDNF, renforce les connexions neuronales et soutient la santé vasculaire dont le cerveau dépend. Les entraînements mentaux comptent aussi. La lecture, les mathématiques, l'apprentissage des langues et les jeux de mémoire contribuent tous à garder les circuits cérébraux souples et résistants.Les choix alimentaires complètent l'approche. Nous décortiquons le régime MIND et ses racines dans les modèles méditerranéen et DASH, en mettant l'accent sur les légumes verts feuillus, les petits fruits, les légumineuses, les grains entiers, les noix, les graines, l'huile d'olive et les oméga-3 provenant du poisson ou des algues. Plutôt que de débattre des étiquettes, nous nous concentrons sur les résultats : une alimentation riche en fibres, un apport protéique adéquat, moins de gras saturés et une grande variété d'aliments végétaux riches en antioxydants et en composés phytochimiques comme les anthocyanines et le sulforaphane. Nous apportons aussi de la nuance à la notion d'aliments « transformés », en expliquant comment l'enrichissement peut être utile, pourquoi toute transformation n'est pas néfaste, et à quel moment les produits ultra-transformés commencent à remplacer une nutrition de qualité.Si vous cherchez un point de départ simple, essayez ceci : comptez les couleurs plutôt que les calories et visez trois à quatre couleurs dans chaque assiette. Construisez de petits rituels, une portion supplémentaire de légumes verts, une marche de 20 minutes, un casse-tête hebdomadaire, qui s'additionnent au fil des mois. Votre cerveau, votre cœur et votre futur vous en remercieront. Si cette discussion vous a parlé, abonnez-vGo check out my website for tons of free resources on how to transition towards a healthier diet and lifestyle.You can download my free plant-based recipes eBook and a ton of other free resources by visiting the Digital Downloads tab of my website at https://www.plantbaseddrjules.com/shopDon't forget to check out my blog at https://www.plantbaseddrjules.com/blog You can also watch my educational videos on YouTube at https://www.youtube.com/channel/UCMpkQRXb7G-StAotV0dmahQCheck out my upcoming live events and free eCourse, where you'll learn more about how to create delicious plant-based recipes: https://www.plantbaseddrjules.com/Go follow me on social media by visiting my Facebook page and Instagram accountshttps://www.facebook.com/plantbaseddrjuleshttps://www.instagram.com/plantbased_dr_jules/Last but not least, the best way to show your support and to help me spread my message is to subscribe to my podcast and to leave a 5 star review on Apple and Spotify!Thanks so much!Peace, love, plants!Dr. Jules

Elizabeth Troy shares the hidden world of fascia and how this 'living matrix' impacts anxiety, why traditional stretching isn't enough, and steps to take to finally feel like yourself again.

Send us a textWhat happens when modern neuroscience, ancient plant medicine, and spiritual self-awareness collide?In this powerful conversation, Joey Pinz sits down with Dr. Leah Linder—naturopathic physician, reverend, and co-founder of Setas Seminary—to explore how psilocybin mushrooms are being used responsibly, ethically, and intentionally to support healing from trauma, PTSD, anxiety, addiction, and cognitive decline.Leah breaks down the actual science behind psilocybin—how it reduces neuroinflammation, stimulates brain-derived neurotrophic factor (BDNF), and helps the brain form new neural pathways—while also explaining why integration and nervous system regulation matter far more than the ceremony itself.You'll also hear why psilocybin became a Schedule I substance, how federal religious protections allow safe access today, and why healing isn't about being “fixed,” but about learning to listen to your body and rewrite old stories.This episode is grounded, thoughtful, and eye-opening—perfect for anyone curious about the future of mental wellness, consciousness, and sustainable personal growth. 

Join My Private Group: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://theaxioncollective.manus.space/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Email List: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://huntershealthhacks.beehiiv.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get My Book On Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://a.co/d/avbaV48Download⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Peptide Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Download The Bioregulator Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠1 On 1 Coaching Application: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscoaching.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book A Call With Me: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscall.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Supplement Sources: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon Storefront: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Socials:Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Video Topic Request: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamsvideotopic.carrd.co/⁠⁠⁠⁠⁠In this episode, I finally dive deep into a peptide I've wanted to talk about for a long time: P21.P21 is what I would call a true brain health peptide. It's not a nootropic in the classic “stimulant” sense, and it's definitely not a limitless-pill type compound. Instead, it works upstream, supporting the brain by upregulating BDNF, enhancing neurogenesis, improving synaptic connectivity, and reducing neuroinflammation.I first heard about P21 years ago through parents of neurodivergent children who were experimenting with intranasal use and seeing meaningful changes. That sent me down the research rabbit hole. Since then, I've used it personally, worked with others using it, and spent a lot of time reviewing the animal data behind it.In this episode, I break down what P21 actually is, how it works mechanistically, why it's often compared to Cerebrolysin (and why it's very different), and where I see its real-world use cases. We talk memory, neurogenesis, Alzheimer's and Down syndrome animal models, traumatic brain injury, vision effects, dosing strategies, safety data, and how I personally cycle it.This isn't hype. There are no human trials yet. But the preclinical data is compelling, and in a world where sourcing Cerebrolysin is harder than ever, P21 stands out as a lighter, more accessible tool for long-term brain health.

Examining the $107B burden of insomnia and its link to a 45% increase in cardiovascular risk, Matt dissects a landmark study of 1,348 participants proving that movement is a potent clinical tool. He also explains how yoga adds nearly two hours of sleep by boosting GABAergic activity, while Tai Chi provides sustained benefits for up to two years.Our host details how exercise facilitates the core temperature drop necessary for consciousness to power down. Matt discusses how movement increases brain-derived neurotrophic factor (BDNF) and turns down the volume on systemic inflammation. In the end, Matt reveals that intentional activity recalibrates the nervous system to help you obtain the best quantity and quality of sleep.Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.Clean biological living requires precision. Podcast partner Caraway's non-toxic ceramic cookware eliminates deleterious "forever chemicals" for a seamless, slide-off-the-pan cooking experience. Save $190 on sets plus 10% off at Carawayhome.com/mattwalker. Caraway. Non-Toxic kitchenware made modern.Another of today's partners is Pique. Their circadian hydration system features a morning BT Fountain for skin and cellular health, plus an evening RE Fountain with triple magnesium for recovery. No sugar or fillers. Get 20% off + a free gift at piquelife.com/mattwalker to start your daily hydration ritual.As always, if you have thoughts or feedback you'd like to share, please reach out to Matt or Eti:Matt: Instagram @drmattwalker, X @sleepdiplomat, YouTube: https://www.youtube.com/@sleepdiplomat

Join us for this episode which is a fast, honest tour through what ketamine can actually do for mental health—without the hype. We sit down with addiction psychiatrist Dr. Mark Hrymoc to unpack where the evidence is strongest, who qualifies, and why IV ketamine often produces quicker relief than nasal esketamine when depression won't budge. From treatment-resistant depression and acute suicidality to anxiety and PTSD, we dig into the protocols that matter: six-session inductions, customized maintenance, and practical strategies for measuring progress with tools like the PHQ-9.We pull back the curtain on how ketamine works at the receptor level—NMDA antagonism, downstream dopamine effects, and BDNF-driven neuroplasticity—and explain why dissociation may help some patients but isn't required for benefit. You'll hear how we screen candidates, manage blood pressure, reduce nausea, and set up sessions with eye masks, ambient music, and a nurse at the bedside so the experience is safe, focused, and grounded. We also get real about addiction risk, clarifying the difference between recreational use and a carefully monitored medical protocol, and how stable recovery timelines factor into clinical decision-making.For PTSD and anxiety, we explore pairing ketamine with psychotherapy and post-session integration to turn insights into change. We compare IV ketamine's dosing flexibility with Spravato's structured pathway, talk costs and coverage, and outline how to taper other meds only after sustained stability. Looking ahead, we spotlight promising research directions—from extending response with adjuncts to early signals for substance use disorders—and why interventional psychiatry is opening a much-needed chapter beyond traditional antidepressants. If you've wondered whether ketamine is a bridge or a destination, this conversation gives you a clear, practical map. Subscribe, share with a clinician friend, and leave a review to help others find evidence-based mental health care.To contact Dr. Grover - ammadeasy@fastmail.com

The sauna is one of the most powerful, research-backed tools for improving cardiovascular health, brain function, athletic performance, and longevity.In this episode, Andrew breaks down the science behind sauna use, including why regular sauna sessions can reduce cardiovascular mortality by up to 50%, improve blood pressure and cholesterol, boost endurance performance, enhance recovery, and support long-term brain health.We also explore how heat exposure triggers heat shock proteins, growth hormone release, increased red blood cell production, and improved detoxification—plus why sauna works best after your workouts, not before.Whether you're an athlete, someone focused on longevity, or just curious about adding sauna use to your routine, this episode gives you clear, evidence-based guidance on how to use sauna safely and effectively.Chapters00:00 Saunas in the Winter01:57 Sauna history: Finland, Russia, Rome06:30 Sauna Boom in the US09:00 Cardiovascular Health12:39 Performance benefits: endurance, blood volume, RBCs + EPO22:00 Heat acclimation + cardio-respiratory fitness + recovery27:30 Muscle preservation: heat shock proteins + sarcopenia31:30 Brain & mental health: dementia risk, mood, BDNF + learning38:00 Cellular repair, detox, pain reliefThe Co-Movement Gym Podcast is supported by Native Path Supplements and Lombardi Chiropractic.

Most women think brain fog in perimenopause is inevitable. It isn't. In this episode, I explain what's really going on: your brain isn't broken, it's running on empty; and that's a solvable biology problem, not a willpower problem. I break down what happens as estrogen and progesterone fluctuate, how that impacts brain energy, and why symptoms like forgetfulness, poor focus, and “slow-motion thinking” can show up even when you're doing everything right. Then I share four science-backed strategies to rebuild a sharper, more resilient brain—covering nutrition, training for cognitive performance, regulating your mental “gears,” and a practical supplement toolkit to amplify the foundations WHAT YOU'LL LEARN: How blood sugar crashes sabotage cognition (and the breakfast fix) Why protein & healthy fats matter for focus in perimenopause The role of omega-3s (EPA/DHA) in neuroinflammation and clarity Why higher-intensity exercise can improve focus via lactate → BDNF How to use training strategically before deep work or high-stakes meetings The 3 Gears framework for focus, creativity, and stress regulation Why micro-breaks between meetings improve engagement and reduce stress buildup The supplement stack discussed (omega-3s, magnesium forms, ubiquinol/CoQ10, B vitamins) How to start with one change and build momentum without overwhelm TIMESTAMPS 00:00 Brain Fog in Perimenopause: What's Really Going On 02:37 Strategy 1: High-Quality Nutrition 05:25 Strategy 2: Exercise for Focus (Lactate, BDNF & Brain Energy) 08:59 Strategy 3: 3 Gears Framework for Focus & Stress 13:05 Strategy 4: The Supplement Toolkit (What Actually Helps) 17:28 How to Reclaim Your Focus & Energy VALUABLE RESOURCES ⁠Join The High Performance Health Community⁠ ⁠Click here⁠ for discounts on all the products I personally use and recommend • Longevity Supplement Masterclass – https://academy.angelafosterperformance.com/longevity-masterclass-27 • Omega-3 Episode featuring Dr. Bill Harris – https://www.youtube.com/watch?v=J42kJPyHPoA A BIG thank you to our sponsors who make the show possible Get 10% off MitoQ NAD+ - www.mitoq.com with code ANGELA Get 35% off Timeline Mitopure by visiting this link while the offer lasts - https://www.timeline.com/promotions/angela35 ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. CONTACT DETAILS ⁠Instagram⁠ ⁠Facebook⁠ ⁠LinkedIn⁠ Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast. This Podcast has been brought to you by Disruptive Media. ⁠https://disruptivemedia.co.uk/

Susan Bratton⁠ discusses the importance of a healthy sex life, the four pillars of longevity, and divulges secrets to your orgasmic potential (spoiler alert: she claims there are 20 different types of orgasms!).

In this episode of Barbell Shrugged, Doug Larson is joined by longtime co-host Travis Mash and new co-host Dr. Mike Lane for a return visit from one of the show's most popular guests, Dr. Tommy Wood. Tommy breaks down the core thesis of his new book, The Stimulated Mind (releasing March 24), which uses dementia prevention as the headline but is really about boosting cognition at every stage of life. The crew sets the tone early: brain health is not "old people stuff," it's performance, learning, and resilience, built daily through how you live and how you train. Tommy makes the case that "optimization" only works when it fits real life, and that the brain adapts like the body: sleep, nutrition, and exercise support it, but you still have to "train the brain" with demanding learning and skills. He outlines a practical learning dose-response, roughly 30–90 minutes of deep challenge per session, 2–3 times per week as a sweet spot for consolidation, while acknowledging the power of daily touchpoints for habit formation (Doug's Duolingo streak and the "don't break the chain" approach). From there, they go deep on exercise modalities and cognition: aerobic work and interval training improving hippocampal function (memory), high-intensity work potentially driving brain benefits through lactate → local BDNF, and coordinative/open-skill sports (racket sports, dancing, martial arts) producing outsized brain returns for the same physical strain. The conversation closes with a fast but important run through risk, genetics, and lifestyle: Tommy explains ApoE4 as a risk multiplier that's highly environment-dependent, amplifying bad inputs (inflammation, poor metabolic health) but also amplifying the benefits of doing the basics well. They hit the big nutrition levers for cognition; omega-3s, key B vitamins (methylation), vitamin D, iron, plus polyphenol-rich foods (berries, cocoa, coffee/tea), and squash the common "red wine" rationalization by emphasizing net outcomes (sleep and brain volume matter). Finally, Tommy emphasizes the under-rated keystone: social connection and pro-social behavior, arguing that the Mediterranean "diet" is really a Mediterranean lifestyle, and that isolation can erase many of the benefits of even a perfect nutrition plan. Links: Doug Larson on InstagramCoach Travis Mash on Instagram  

What if your next big idea isn't hiding in your to-do list, but in your stride? We explore how moving your body can unlock mental clarity, creative problem solving, and a resilient identity you can trust under pressure. This isn't hype; it's a practical playbook backed by neuroscience, sports psychology, and hard-won stories from leaders, creators, and everyday high performers.We break down the embodied confidence loop: small physical wins become mental evidence, which then fuels bolder actions across your work, relationships, and creative pursuits. You'll hear why BDNF and increased prefrontal blood flow make walking, running, and even gentle stretching powerful tools for ideation and focus. We talk posture and presence, drawing on embodied cognition research to show how standing like a leader helps you think like one. From a tech executive who used boxing to transform stage fright into stage presence, to an entrepreneur who scaled past a revenue ceiling after rock climbing rewired his relationship with risk, you'll see how courage and clarity transfer across domains.Then we get tactical. Use the movement breakthrough technique when you're stuck: step away with intention and let motion change your state. Try the power position reset before high-stakes moments. Practice the breakthrough breath to calm the nervous system and widen attention. Build physical anchors—simple gestures that cue confidence on command. If time is tight, micro workouts and walking meetings can deliver outsized gains in decision quality and creativity. Expect resistance and treat it as a signal to move. Choose one stuck area, one small physical practice, and repeat with consistency and intention.Ready to build a body that your mind can trust? Press play, pick your next move, and let movement and mindset compound your results. If this resonated, subscribe, share with a friend, and leave a review to help others find the show.Illuminate Your World with Kore Candles!Kore Candle Company is a brand that specializes in creating unique and high-quality soy candles. Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showhttps://www.kore-fit.com

It's a controversial topic, fasting, especially for women. Dr. Mindy Pelz was teaching women to fast primarily because they wanted to lose weight, but what she was witnessing was women saying things like, "I lost weight, but my hair's falling out. I don't have a period anymore. I sat down with Dr. Mindy Pelz, New York Times bestselling author of Age Like a Girl, hormone expert, and the voice redefining fasting for women - because doing it wrong can wreck your health. We explore why fasting affects women differently, how ketones can restore brain function during menopause, and why understanding your hormonal cycle is critical for metabolic health, cognitive performance, and longevity. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro 01:50 What put Dr. Mindy Pelz on the map 03:14 The truth about fasting vs intermittent fasting 05:13 How the brain uses glucose vs ketones 07:25 Why the brain "eats itself" during menopause 10:14 What is mitophagy and cellular autophagy 13:11 Why autophagy is the body's repair system 15:24 The 12-hour vs 17-hour vs 72-hour fast 17:23 Why women's cycles are disrupted by fasting 19:59 The fasting cycle for women 21:05 Lactate as a fuel source for the brain 23:01 Hemoglobin A1C and insulin resistance 27:36 Understanding CGM data correctly 30:13 Where women should start at 48 32:01 HRT: personal decision or necessity? 34:15 The nervous system shift during perimenopause 38:48 The grandmother hypothesis and evolutionary sensitivity 41:09 The "menopause divorce" phenomenon 44:18 Dementia, Alzheimer's, and women46:17 Dopamine, novelty, and neuroplasticity47:23 Cold water immersion and trauma rewiring51:19 Cold water and cortisol for women53:51 Exercise, BDNF, and brain health55:21 Serotonin, light exposure, and sleep58:00 Glycine, bone broth, and longevity01:02:26 Preparing for perimenopause and menopause 01:04:24 Acetylcholine, storytelling, and memory 01:08:38 Why eggs and cholesterol matter for the brain _______ A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Ketone-IQ: Mental clarity that lasts - without the crash. Visit https://ketone.com/NEURO for 30% OFF your subscription order - PLUS receive a free gift with your second shipment or find Ketone-IQ at Target stores nationwide and get your first shot free! IQBAR: The New Year gives us all a chance to reset. Maximize your brain and body's potential with IQBAR's protein bars, hydration mixes, and mushroom coffees. Text NEURO to 64000 to get 20% off all IQBAR products, plus FREE shipping. Caraway: Visit Carawayhome.com/neuro10 or use code neuro10 at checkout to take an additional 10% off your next purchase. Caraway. Non-Toxic cookware made modern. Cure Hydration: For The Neuro Experience listeners, you can get 20% off your first order at curehydration.com/NEURO with code NEURO. Cure is FSA/HSA approved, so you can use your FSA or HSA funds to stay hydrated the smart way. Jones Road Beauty: Use code NEURO at jonesroadbeauty.com to get a Free Cool Gloss with your first purchase! _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

Broadcast from KSQD, Santa Cruz on 1-01-2025: An emailer asks about omega-3 supplementation for memory at age 72. Dr. Dawn advises checking that fish oil capsules contain adequate DHA—at least 1,000 mg—since many omega-3 products have low DHA levels. She notes Medicare covers the same testing at standard labs as proprietary labs like OmegaQuant that charge patients directly. Beyond omega-3s, she emphasizes glucose control (hemoglobin A1c below 5.6) since the enzyme that breaks down insulin also clears beta-amyloid, and weight training to raise brain-derived neurotrophic factor (BDNF), which promotes new synapse formation essential for memory. Dr. Dawn reviews Popular Science's top 2025 health innovation: eye drops from Lens Therapeutics containing aceclidine that correct age-related farsightedness for 10 hours. The drops shrink the pupil to increase depth of field, improving near vision by three or more lines on eye charts within 30 minutes without affecting distance vision. Side effects include eye irritation, dimmed night vision, and headache. She describes Duke University's breakthrough allowing heart transplants from circulatory death donors using an on-table reanimation technique. This could expand the pediatric donor pool by 20%—critical since up to 20% of children die waiting for transplants. Dr. Dawn celebrates CAR-T immunotherapy for multiple myeloma, which saved her husband's life. Of 97 heavily pretreated patients, 38% achieved complete remission still present at five years, with over 50% total survival. The therapy removes T-cells, uses CRISPR to add receptors targeting cancer cell antigens, then reinfuses the modified cells. She highlights a UC Davis study showing remote blood pressure monitoring with home technology, education, and coaching dropped patients' average blood pressure from 150/80 to 125/74 in months—low-tech with high impact. Dr. Dawn explains the Nano Knife for prostate cancer, which uses localized electrical pulses delivered through thin wires to destroy tumors while sparing surrounding nerves. This minimally invasive approach could reduce erectile dysfunction and incontinence common with traditional surgery. She describes Gilead's Sunlenca, a twice-yearly injection for HIV prevention that's 99% effective. At $14,000 per injection in the US, proceeds help fund access in resource-limited countries where it can be distributed like a vaccination. Dr. Dawn discusses Journavx (suzetrigine), a new non-opioid pain medication working on sodium channels to block pain signals before reaching the brain. At $30 for 50 pills on GoodRx, it offers an alternative for surgical pain in patients with addiction history or genetic vulnerability to opioid dependence. She details the landmark case of Baby KJ, the first person to receive personalized CRISPR gene therapy. Born with a CPS1 enzyme deficiency causing toxic ammonia buildup, KJ was too small for liver transplant. Scientists identified his specific mutation and used CRISPR base editing delivered via lipid nanoparticles to correct a single DNA letter—changing an A to G—in his liver cells which restored enough function to be discharged home. Dr. Dawn reports surprising findings that COVID mRNA vaccines amplify cancer immunotherapy. Lung cancer patients who received COVID vaccination within 100 days of checkpoint inhibitor treatment had 56% three-year survival versus 31% for unvaccinated patients. The mechanism is unknown but may involve mRNA generally alerting the immune system. She revisits research showing Zostavax shingles vaccination reduced dementia risk by 20% over seven years. A natural experiment in Wales—where an age cutoff created comparable vaccinated and unvaccinated groups—provided strong evidence that preventing herpes zoster inflammation protects brain health. Dr. Dawn concludes with Huntington's disease breakthrough: microRNA therapy delivered by virus directly into the brain slowed disease progression by 75% over three years. The microRNA binds to Huntington protein mRNA, preventing ribosome translation and toxic protein production. Some patients returned to work; others expected to need wheelchairs are still walking.

Send us a textCellular metabolism, mitochondrial health, and the roles of diet and environment in metabolic health, fetal & child development, and Alzheimer's.TOPICS DISCUSSED:Cellular growth vs. burning: Cells alternate between growing (using glucose for building blocks in low-oxygen environments) and burning (generating ATP in mitochondria with oxygen); dysregulation leads to metabolic issues.Key regulatory enzymes: PI3 kinase imports glucose, AMP kinase builds mitochondria, and mTOR drives cell division; their synchronization determines healthy modes, while desynchronization causes diseases.Fructose as a dose-dependent mitochondrial toxin: High fructose intake inhibits AMP kinase, reducing mitochondrial function and diverting energy to fat storage; it is dose-dependent, like alcohol, and unnecessary in the diet.Obesogens & endocrine disruptors: Chemicals like tributyltin (TBT) alter gene expression across generations, promoting obesity unrelated to calories; modern exposures increase reactive oxygen species (ROS), burdening cells.Fetal & neonatal development: Maternal diet, especially high sugar or formula feeding, can cause neonatal obesity and fatty liver; breastfeeding supports proper jaw development and oxygen intake.Brain metabolism & Alzheimer's: The brain's high energy needs make it vulnerable to mitochondrial issues and ROS; energy deficits from diet, stress, and toxins lead to synapse loss and inflammation, treatable via prevention.ROS & health: Mitochondria produce ROS as a byproduct of ATP generation; excess from diet or environment causes damage, but antioxidants and lifestyle can mitigate risks.PRACTICAL TAKEAWAYS:Limit added sugars in your diet to reduce mitochondrial stress and ROS, focusing on whole foods over ultra-processed items for better metabolic health.Prioritize breastfeeding for infants when possible to support proper physical development and reduce future metabolic risks.Incorporate regular exercise and social activities to manage stress and boost brain-protective factors like BDNF, aiding neurodegeneration prevention.Get adequate sleep to regulate cortisol and maintain cellular energy balance, helping prevent brain fog and chronic diseases.ABOUT THE GUEST: Robert Lustig, MD is a pediatric endocrinologist and Professor Emeritus at the University of California, San Francisco, with a background in neuroendocrinology and obesity research.*Not medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

What if the gap between your age and your energy is wider than you think—and fixable? That's the wager we make as we sit down with longevity strategist Bob Gilpatrick to unpack why most people lose health, not just time, in their final decade and how to reverse that trend with measurable steps. We trace his journey from a near-fatal crash at 17 to a career spanning plant science roots, healthcare leadership, and breakthroughs that blend targeted nutrition with mind-body mastery.We get practical fast: CRP as a “burn rate” for your body, why keeping it below 0.5 changes everything, and how a complete nutrient strategy powers real mitochondrial energy instead of caffeine jitters. Bob explains epigenetic reprogramming—plant-derived, purified molecules that nudge gene sets for muscle, energy, NAD, and BDNF—plus why they can outperform complex peptide stacks at a fraction of the cost. He pairs these advances with essential building blocks: amino acids, enzymes, and minerals that allow your body to build what your genes request. The result? Faster strength gains, better motivation, and noticeable changes many feel within days.We also go beyond biology to the beliefs that block action. You'll hear how EFT tapping and havening calm the nervous system, reduce cravings, and resolve grief or fear by changing brain states in real time. From cartilage support that challenges “once it's gone, it's gone” to sustainable weight loss that protects muscle, this episode is a blueprint for adding strong, clear years—healthspan—to your life. If you're ready to test, adjust, and prove it in your own bloodwork and daily energy, this conversation gives you the steps and the science.Subscribe, share with a friend who needs a push, and leave a review telling us the one change you'll make this week. Then visit boomerboost.com for details and use promo code Omar at checkout.Join the What if it Did Work movement on FacebookGet the Book!www.omarmedrano.comwww.calendly.com/omarmedrano/15min

Consistently moving your body in a way that you enjoy is the best route to optimal health. However, in recent years emerging science has shown the benefits that sprint training can have on human health. On this episode of The Model Health Show, you're going to learn about the science of sprinting.  Today's guest, Cynthia Monteleone is a 400-meter world champion masters sprinter and decathlete who ran her fastest times in her 40s. Cynthia is also a metabolic practitioner who works with clientele ranging from Olympians to everyday folks. She is an expert on sprinting over 40, and on today's show she's sharing the top 10 reasons why sprinting is better than endurance training for longevity.  You're going to learn how sprinting can affect everything from your gut health to your heart health, the best ways to burn fat, and more. Cynthia is also sharing her personal experience becoming an athlete during midlife and how beginners can start sprint training. Cynthia's message is that it's never too late to empower yourself to reach your goals, and I hope this episode resonates with you!   In this episode you'll discover:  The top ten reasons why sprinting is better than endurance training for longevity. (2:43) How endurance training impacts gut health. (4:50)  The link between sprinting and BDNF production. (5:18) How sprinting impacts fat burning. (7:57) Why sprinting can aid in heart health. (13:18) What dynapenia is. (25:08) How Cynthia became a world champion masters sprinter. (29:23) What Cynthia eats to support her neurotransmitters. (34:45) How beginners can build up to sprinting. (45:05) Which strength training exercises are best for sprinters. (45:57) How to improve your form and breathing while sprinting. (53:34)  Items mentioned in this episode include:  Organifi.com/Model - Use the coupon code MODEL for 20% off + free shipping! Fast Over 40 by Cynthia Monteleone - Check out Cynthia's book here! Connect with Cynthia Monteleone Website / Shop / Instagram  Be sure you are subscribed to this podcast to automatically receive your episodes:   Apple Podcasts  Spotify  Soundcloud  Pandora  YouTube    This episode of The Model Health Show is brought to you by Organifi. Organifi makes nutrition easy and delicious for everyone. Take 20% off your order with the code MODEL at organifi.com/model. 

Butyrate, produced by gut bacteria when they ferment dietary fiber, acts as a signaling molecule in the gut-brain axis, influencing stress, pain tolerance, immunity, and brain health Through multiple mechanisms, including specific enzyme inhibition and NF-κB pathway regulation, butyrate reduces neuroinflammation and protects against neurodegenerative conditions like Alzheimer's and Parkinson's disease Butyrate influences key neurotransmitters including GABA, serotonin, and dopamine, while also increasing brain-derived neurotrophic factor (BDNF), which supports neuronal growth and cognitive function The vagus nerve serves as a communication highway between the gut and the brain, transmitting signals about butyrate levels that affect mood regulation, stress response, and immune function Optimizing gut health through dietary fiber and homemade fermented foods helps promote butyrate production and maintain a healthy gut-brain connection

Neil steps away from traditional business tactics to focus on the essential foundation of any successful venture: the health and well-being of the entrepreneur. He explores the concept of ‘The Fasting Miracle', specifically focusing on water fasting and its transformative effects on the body and mind. He breaks down the biological processes that occur during various stages of fasting, from the initial fed state to deep cellular repair and regeneration. By sharing his personal 21-day fasting experience and detailing the scientifically supported benefits, such as increased mental clarity, fat loss, and immune system rebooting, Neil provides a compelling case for fasting as a no-cost tool for tutors and coaches to optimise their performance and longevity. KEY TAKEAWAYS Maintaining good health is a critical business issue because it forms the foundation for everything a business owner does. Fasting triggers natural mechanisms like lipolysis (fat burning) and ketosis, where the body switches from burning glucose to burning stored fat and ketones for cleaner, steadier energy. Between 20 to 24 hours of fasting, the body initiates autophagy - a "self-eating" process where damaged cells and proteins are recycled into useful materials, reducing inflammation and the risk of degenerative diseases. Extended fasting (72+ hours) can eliminate old white blood cells and stimulate stem cell production to create a new, more efficient immune system. BEST MOMENTS "Health is the foundation on which everything we do is built. So staying healthy is a business issue." "Fasting isn't some brand new trendy fufu-dufu woo-woo fad. People have been doing it for centuries." "Autophagy is cellular cleanup and repair. The damaged proteins and organelles that are flapping around your body are broken down and recycled into useful stuff." "BDNF supports brain health and cognitive function. I've heard BDNF often called miracle grow for the brain, and that's what it does." "The longer I fasted, the better I felt. My mental sharpness increased like it's hard to explain. I just got sharper, faster." VALUABLE RESOURCES www.Neilcowmeadow.com info@neilcowmeadow.com HOST BIO Neil Cowmeadow is a maverick peripatetic guitar teacher from Telford with over 19 years' experience in the business of helping people. Learn how to start, grow and love your business with Neil's invaluable advice and tips without the buzzwords and BS! This Podcast has been brought to you by Disruptive Media. https://disruptivemedia.co.uk/

Kylen Ribeiro shares essential ways to reduce your radiation exposure, explaining why holding your phone to your head, placing a laptop on your lap, and using some smart devices carry potential risks.

What if thousands of steps of gentle walking aren't giving you the brain protection you think they are? In this solo episode, I break down one of the most important exercise studies published in Nature Communications and what it means for your brain, longevity, and Alzheimer's risk. Tracking over 73,000 people for eight years using wearables, the findings are shocking: one minute of vigorous exercise is worth up to 10 minutes of moderate activity — not the outdated 2-to-1 rule. For diabetes prevention, it's nearly 10-to-1. For cardiovascular mortality, it's 8-to-1. And here's what no one is saying: every outcome measured — heart disease, diabetes, metabolic dysfunction — is an independent risk factor for Alzheimer's and dementia. I explain why vigorous exercise is so powerful for your brain: shear stress that strengthens blood vessels, lactate that triggers BDNF, muscle fiber recruitment that protects against falls and cognitive decline, and glucose regulation that defends against insulin resistance — a driver of neurodegeneration. Think vigorous exercise is out of reach? Good news: the study defines it as brisk stairs, carrying groceries, or playing actively with your kids. No gym required — just effort. Just 3–4 minutes of vigorous bursts per day can reduce all-cause mortality by 40% and cardiovascular events by nearly 50%. For women over 40, this is critical. Two-thirds of Alzheimer's cases are women, and perimenopause is a vulnerability window for the brain. Vigorous exercise can partially compensate for declining estrogen by improving glucose regulation, reducing inflammation, and protecting the brain in ways gentle movement cannot. *** Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/brain-code-yt Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Rho NutritionYou can get 20% off with the code NEURO at https://rhonutrition.com Function HealthVisit https://functionhealth.com/louisa or use gift code NEURO100 at sign-up to own your health. AquaTruGo to https://AquaTru.com now for 20% off using promo code NEURO. TimelineHead to https://www.timeline.com/neuro to get 20% off. Cure HydrationGet 20% off your first order at https://curehydration.com/neuro with code NEURO. *** I'm Louisa Nicola — clinical neurophysiologist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Topics discussed:00:00:00 Introduction: The Exercise Intensity Revolution 00:01:02 The Study That Changes Everything 00:04:50 The Flawed Foundation: Why Guidelines Were Wrong 00:06:50 The Real Numbers: 4 to 10 Times More Powerful 00:08:53 The Brain Connection No One Is Talking About 00:15:32 Mechanism 1: Shear Stress and Cerebral Blood Flow 00:17:38 Mechanism 2: Lactate and BDNF Production 00:19:25 Mechanism 3: Type 2 Muscle Fibers and Myokines 00:24:30 Mechanism 4: Glucose Regulation and Mitochondrial Health 00:28:18 VILPA: The 3-Minute Daily Game Changer 00:32:16 Women and Menopause: The Critical Window 00:35:19 Practical Protocols: What to Do Starting Today Learn more about your ad choices. Visit megaphone.fm/adchoices

Send us a text if you want to be on the Podcast & explain why!Ever feel the ground shift under a job you once loved? We sit down with a K–12 principal who built his identity around coaching kids, weathered the Paradise fire, and still found his purpose dissolving under politics, ego, and endless pushback. What follows is a candid look at walking away from a steady six-figure paycheck to pursue fitness, craft, and a life that feels honest again.We trace the throughline from early days lifting in Chico to leading schools where every decision meets resistance, and then to the spark of a new path: training, education reform from the outside, and programs that make movement central to learning. We talk openly about comfort as a trap, the fear of starting at zero, and the mindset shift that turns practice into momentum. If you're wrestling with a pivot, you'll hear a practical playbook: shadow great coaches, study daily, build a routine that stacks mobility, lifting, and focused learning, and have one meaningful industry conversation every day. It's career capital by design, not hope.There's a strong case for bridging education and fitness. PE gets sidelined, yet aerobic work boosts BDNF, sharpens attention, and primes the brain for class. With the right partnerships, schools can implement zero-period training, teacher wellness, and skill-based PE that kids actually believe in. This isn't about quick wins; it's about craft, clarity, and owning your trajectory. If you're choosing between safe and alive, this conversation will nudge you toward the path that compounds.If this resonates, follow the show, share it with someone stuck in a comfort loop, and leave a review with the bold move you're planning next. Keep showing up.Want to become a SUCCESSFUL personal trainer? SUF-CPT is the FASTEST growing personal training certification in the world! Want to ask us a question? Email info@showupfitness.com with the subject line PODCAST QUESTION to get your question answered live on the show! Website: https://www.showupfitness.com/Become a Successful Personal Trainer Book Vol. 2 (Amazon): https://a.co/d/1aoRnqANASM / ACE / ISSA study guide: https://www.showupfitness.com

Listen as host Amy Rodquist-Kodet, Health Coach with UK HR Health and Wellness, shares simple, research-backed practices to help steady your mood during the dark Winter months. Seasonal Affective Disorder (SAD) impacts millions each year, but small actions—light exposure, gentle movement and self-compassion—can make a meaningful difference. Amy says, “These practices aren't about fixing everything at once; they're about shifting your internal weather by a few degrees, building resilience over time.”Key Points:• Light: Morning light exposure is a powerful cue for your circadian rhythm. Even a short burst of brightness—like turning toward a window or a bright lamp—can support a more positive circadian rhythm.• Movement: Just 10 minutes of low-intensity movement can increase BDNF, a brain chemical tied to emotional stability and resilience. Think of gentle movements like rolling your shoulders or shifting in your seat.• Self-Compassion: Brief moments of self-kindness reduce stress and regulate the nervous system. Pairing a small action with a compassionate phrase—such as “I deserve steadiness and kindness”—makes the practice more powerful and sustainable.

In this episode of The Eric Bach Show, Eric breaks down seven specific foods that make losing stubborn belly and visceral fat easier—not by “magic,” but by improving insulin sensitivity, metabolism, gut health, inflammation, and hormone balance. You'll learn how to build meals that keep you full, support longevity, and help you look great naked… without starving yourself or living in the gym. Why the same foods that help you get leaner also protect your brain, mitochondria, DNA, and cardiovascular system as you age. The 7 Foods Eric Breaks DownCoffeeBoosts metabolic rate (roughly 3–11% in studies).Increases fat oxidation during exercise and can blunt appetite earlier in the day.Loaded with polyphenols like chlorogenic acid that support liver health, reduce oxidative stress, and may lower risk of neurodegenerative disease—as long as you're not turning it into a 500-calorie dessert drink. Lean Beef or Bison (93–95% lean)High-protein, nutrient-dense source with iron, zinc, B12, creatine, and some omega-3s (especially in grass-fed and bison).Higher protein = more thermogenesis, more satiety, better lean-mass retention in a deficit.CLA and omega-3s are linked to reductions in visceral fat and improved metabolic health. Wild BlueberriesImprove insulin sensitivity and help stabilize blood sugar, reducing cravings.High in fiber plus powerhouse antioxidants and polyphenols (anthocyanins) that support brain health, BDNF, and mitochondrial protection.Wild varieties can have 2–3x the antioxidant load of regular blueberries. Broccoli (and other crucifers)Ultra high volume, low-calorie, fiber-rich—great for appetite control and blood sugar stability.Rich in sulforaphane, which activates NRF2 (your body's “master antioxidant switch”) to support detoxification, lower inflammation, and protect DNA from damage. Greek Yogurt (2% or Non-Fat)High in protein to preserve muscle and support metabolism during fat loss.Probiotics support gut health, digestion, inflammation, and immune function.Fermented dairy is linked to better microbiome diversity and improved longevity markersLeafy Greens (Spinach, Kale, Arugula, Romaine, etc.)Low-calorie, high-volume, packed with folate, vitamin K, magnesium, nitrates, and antioxidants.Support insulin sensitivity, stress management, cardiovascular health, and nitric oxide (better blood flow, performance… and erections).Simple habit: a “big-ass salad” at dinner most nights. Wild-Caught SalmonElite combo of high-quality protein and omega-3 fats (EPA + DHA).Helps improve insulin sensitivity, lower systemic inflammation, and reduce cardiovascular risk by ~25–35% in some research.Supports brain function, mood, joint health, and telomere protection—huge for longevity and preserving leanness as you age. Big TakeawaysYou don't need “fat-burning foods”—you need fat-loss friendly foods that make a calorie deficit sustainable.Focus on foods that either had a face or came from the ground: protein + fiber + micronutrients beat pills, potions, and powders.Start by consistently adding 2–3 of these foods into your daily rotation, then build from there. Who This Episode Is ForAnyone struggling with stubborn belly fat despite “eating

We explore how movement reshapes the mind, builds self-trust, and reconnects you with your body's wisdom. Science, stories, and a guided practice show why intention and consistency—not intensity—unlock healing and growth.• reframing exercise beyond aesthetics toward agency • Sarah's story of confidence and identity change • brain chemistry and BDNF-driven neuroplasticity • movement as a tool for control and resilience • nervous system regulation and mindful presence • Marcus's rock climbing and rebuilding trust • somatic approaches for trauma and emotion release • debunking intensity myths and widening access • choosing modalities by desired feeling state • practical starting steps and consistent habits • guided mindful movement sequence for listeners • closing resources and community supportIf you'd enjoyed today's episode, I'd love for you to share it with your friends and family And if you're feeling generous, consider donating at the link provided in the description For more resources, tips, and updates, don't forget to visit our website at www.kore-fit.com and follow us on Instagram at KoreFitnessAZIlluminate Your World with Kore Candles!Kore Candle Company is a brand that specializes in creating unique and high-quality soy candles. Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showhttps://www.kore-fit.com

For decades, the topic of menopause has been overlooked, misunderstood, and undertreated. As more science emerges, more experts are sharing the truth about how women's brains and bodies shift during this important, transformative change. On today's show, you're going to learn about what actually happens during menopause and how to embrace and reclaim menopause.   Today's guest, Dr. Mindy Pelz, is a New York Times bestselling author, functional health expert, and a leading voice in women's health, hormonal health, and aging. She's back on this episode of The Model Health Show to share the science and tangible takeaways from her new book, Age Like a Girl. In this interview, Dr. Mindy is sharing details about the hormonal shift that happens during menopause, and how women (and their families) can honor this transition.   You're going to learn about how using lifestyle practices like weightlifting and fasting can help women balance hormones, eliminate brain fog, and boost their energy levels. You'll learn why there is so much misinformation and outdated narratives surrounding menopause, the science of neurochemical shifts, and how midlife can be a time to step into leadership and purpose. I hope you enjoy this interview with the one and only, Dr. Mindy Pelz!   In this episode you'll discover:  The meaning behind Dr. Mindy's new book, Age Like a Girl. (3:47)   How the female brain rewires during menopause. (4:22)  What the relational brain is and how it is impacted by hormones. (10:04)  How environmental factors are changing the menstrual cycle. (13:40)  What the grandmother hypothesis is. (22:21)  The two main metabolic systems and how they work. (25:02)  What estrogen's girl gang is. (26:28)  How levels of insulin and glucose change during menopause. (27:42)  The relationship between estrogen and dopamine. (32:59)  Which supplement is a nutritional necessity for post-menopausal women. (42:01)  How to naturally increase BDNF levels. (43:06)  The importance of in-person knowledge sharing and storytelling. (46:27)  What the toxic dump of menopause is. (58:48)  Free or low-cost ways to naturally detoxify. (1:04:39)  How men can support their partners through the process of menopause. (1:10:35)  Items mentioned in this episode include:  ⁠Thelumebox.com/model⁠ ß Get an exclusive $260 off your red light therapy device!  ⁠Piquelife.com/model⁠ ß Get exclusive savings on bundles & subscriptions!   Age Like a Girl by Dr. Mindy Pelz⁠ ß Preorder your copy of the book today! Connect with Dr. Mindy Pelz ⁠Website⁠ / ⁠Podcast⁠ / ⁠Facebook⁠ / ⁠Instagram⁠ / ⁠YouTube⁠ Be sure you are subscribed to this podcast to automatically receive your episodes:   Apple Podcasts  Spotify  Soundcloud  Pandora  YouTube    This episode of The Model Health Show is brought to you by Lumebox and Pique.   The LUMEBOX is clinically designed to deliver both red (660 nm) and near-infrared (850 nm) wavelengths in one sleek handheld device. Independently lab-tested for performance: more coverage, higher irradiance, and a greater effect. Enjoy an exclusive $260 off the premium LUMEBOX red light therapy system, designed to boost recovery, skin health, and overall vitality by using my exclusive link: thelumebox.com/model.  Go to Piquelife.com/model for exclusive savings on bundles & subscriptions on cutting-edge solutions for your head-to-toe health and beauty transformation. 

Trauma does not just live in your memories. It reshapes your brain. It can shrink your hippocampus, disrupt your prefrontal cortex, heighten your stress response, and leave you feeling stuck in survival mode. But the good news is this. Your brain is not fixed. It can heal. It can rewire. And one of the most powerful tools to rebuild a trauma-affected brain is movement.In this episode, I break down the neuroscience of how trauma changes the brain and how exercise can stimulate neuroplasticity, grow new brain cells, repair damaged pathways, and restore your ability to focus, learn, and feel in control again.You will discover why BDNF acts like fertilizer for your brain, how aerobic movement grows the hippocampus, why pairing exercise with mindfulness accelerates healing, and how to create a simple step-by-step plan to rebuild your brain even if you feel busy, stressed, or unmotivated.I also guide you through a seven day brain healing challenge you can start today and share how sleep, nutrition, connection, and lifelong learning work together to create the ultimate environment for recovery.This episode will show you how one small step can ignite big healing and longevity. Your brain can change at any age and any stage. And you can start rebuilding today./ / / Are you ready to take the next step on your brain optimization journey? / / /Choose your own adventure. Below are the best places to start:>>> Join Limitless Live 2025 Virtual Experience >>> Master Exceptional Memory Skills in 31 Days>>> Discover Your Unique KWIK BRAIN C.O.D.E To Activate Your GeniusTake your first step by choosing one of the options above, and you will find everything you need to ignite your brilliant brain and unlock your exceptional life, allowing you to achieve and surpass all of your personal and professional goals.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Dr. Jockers reveals the simplest yet most powerful strategy to heal and protect your brain: intermittent fasting. By stabilizing blood sugar and reducing insulin levels, fasting supports mitochondrial health, which is crucial for maintaining brain function and preventing degeneration.   You'll learn how brain degeneration isn't something that happens overnight, but rather a 30–40 year process that starts early, often in childhood. Dr. Jockers explains how poor metabolic health over time can silently damage the brain, leading to conditions like dementia and Alzheimer's.   Finally, discover how intermittent fasting not only supports brain repair but also activates powerful neuroprotective mechanisms, including the production of BDNF, a critical factor for brain regeneration. It's a simple lifestyle shift with profound long-term effects on cognitive health.   In This Episode:  00:00 Introduction to Intermittent Fasting and Brain Health 02:34 The Rise of Brain Degeneration 03:41 Benefits of Intermittent Fasting 09:28 Understanding Neuroinflammation 13:02 Preparing for Intermittent Fasting 15:44 Conclusion and Final Thoughts Struggling with digestion? Masszymes by BiOptimizers is the most potent digestive enzyme formula, featuring 300-500% more protease than most brands. This powerful blend breaks down proteins and other macronutrients, reducing bloating, inflammation, and indigestion. Try Masszymes risk-free with a 365-day money-back guarantee. Boost your digestion and feel your best—get yours today at bioptimizers.com/jockers and save 10% with promo code 'JOCKERS'! If you're serious about reducing your toxic load, I highly recommend upgrading to the P600 ceramic cookware. It's 100% free from Teflon, PFAS, and plastic coatings, ensuring a non-toxic cooking experience. Right now, you can get it for 50% off, plus an extra 20% off with the code SAFE20 at checkout! Don't miss this limited-time offer—head to chefsfoundry.com/jockers to claim your discount today!     "You don't just wake up with dementia — it's a 30–40 year process silently damaging your brain long before symptoms appear."  ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Use code JOCKERS at bioptimizers.com/jockers to save 10% Use code Safe20 at chefsfoundry.com/jockers     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

In this episode, Ben Azadi breaks down the science and real-life experience behind a 36-hour fast, explaining why this specific fasting window creates a powerful metabolic, hormonal, and cellular reset. Ben walks listeners through the hour-by-hour stages of the fast — from digestion, to fat burning, to deep autophagy — and explains how fasting transforms the body at every level. He covers increases in human growth hormone, gut repair, ketone production, mitochondrial upgrades, and the mental clarity that comes from elevated BDNF. He also answers the most common questions about long fasts:• What drinks or supplements break a fast• Whether women should modify fasting based on their cycle• How often to repeat a 36-hour fast• What symptoms are normal vs. concerning• Whether fasting impacts muscle• How to eat before and after a long fast for best results Ben also explains who should not attempt a 36-hour fast and how to break the fast without losing the benefits. He emphasizes that fasting is not starvation — it's a biological event designed for healing, fat loss, and metabolic restoration. FREE GUIDE: The World's Easiest Breakfast Diet - https://bit.ly/4puckHV 

Dr. Hoffman continues his conversation with Alan Frost, founder of Flava Naturals, and Dr. Joseph C. Maroon, MD, FACS, clinical professor and vice chairman of the Department of Neurological Surgery and Heindl Scholar in Neuroscience at the University of Pittsburgh Medical Center, and author of "The Science of Cocoa."

Alan Frost, founder of Flava Naturals, and Dr. Joseph C. Maroon, MD, FACS, clinical professor and vice chairman of the Department of Neurological Surgery and Heindl Scholar in Neuroscience at the University of Pittsburgh Medical Center, and author of "The Science of Cocoa," detail recent scientific findings on the cardiovascular and cognitive benefits of cocoa flavanols, the importance of sourcing and processing cocoa, and how cocoa can enhance athletic performance and brain health. The episode also covers the benefits of cocoa for skin health, fighting inflammation, and even mitigating some of the effects of sitting. Dr. Maroon elaborates on his protocols for concussion recovery, including the use of omega-3 fish oil, creatine, and CBD. The episode concludes with a discussion on how cocoa impacts mood and a special discount offer for Flava Naturals products. Just go to FlavaNaturals.com and use coupon code HOFFMAN20 for 20% off site-wide, plus get free shipping on all orders over $30.

On this episode of Vitality Radio, Jared dives deep into one of the most fascinating frontiers in functional nutrition—brain energy. He unpacks how ATP fuels your mind, why BDNF acts like “fertilizer for neurons,” and how lifestyle stressors, toxins, and poor sleep can dim your mental lightbulb. From there, he explores the natural tools that can reignite focus, memory, and long-term cognitive vitality. You'll hear how powerhouse nutrients can support mitochondrial performance, boost brain-derived neurotrophic factor, and promote sharper thinking—without the crash of caffeine or pharmaceuticals. Jared wraps up with three practical, results-driven protocols: one for focus and ADHD support, one for immediate memory and cognition, and one for long-term prevention of cognitive decline. Each stack can be customized to fit your individual goals so you can think clearer, focus longer, and age smarter—naturally.Brain Boosting Protocol CollectionShop the collection! Bundle and save - no code needed, just add to your cart to get:Buy 2 at 10% offBuy 3-4 at 15% offBuy 5+ at 25% offAdditional Information:Brain Boosting Protocol Blog Post#335: The Latest Research on Preventing and Reversing Dementia and Alzheimer's with Dr. Dale Bredesen#570: Liquid Yoga & Mind Fuel: Harnessing Mushrooms and Herbs for Focus and Calm#511: Unraveling NAD+ and NMN for Longevity and Anti-AgingVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Upgrade your week in just 10 minutes with D(AI)ve Asprey's essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. This episode covers: • Apple Cider Vinegar Myth Busted A weight-loss study just got retracted. ACV will not melt fat, but it may blunt glucose spikes or ease digestion when diluted in water before carb-heavy meals. Skip the shots and protect your teeth. Source: https://www.sciencedaily.com/releases/2025/10/251001092216.htm • NMN Is Back The FDA reversal puts NMN back on shelves as a clean NAD precursor. Dave explains why quality, cycling, and stacking with anti-inflammatory strategies make the difference. Source: https://www.prnewswire.com/news-releases/renue-by-science-celebrates-fda-reversal-confirming-nmn-is-lawful-for-use-in-dietary-supplements-302573317.html • Poor Sleep Ages Your Brain Machine learning MRI studies show poor sleep makes your brain biologically older and raises dementia risk. Dave shares the three dials to track (deep sleep, REM, resting heart rate) and the three biggest levers to fix them. Source: https://www.sciencedaily.com/releases/2024/10/241023171543.htm • Psilocybin for Lasting Reset New research finds a single guided dose can unlock plasticity, ease pain patterns, and lift mood for weeks. Dave outlines safe protocols, integration steps, and why it is a strategic reset tool, not a party trick. Source: https://www.sciencedaily.com/releases/2025/06/250616040215.htm • AI Detects Cancer Earlier A new AI tool called DOLPHIN can find hidden genetic markers to flag cancer risk sooner. Pairing high tech scans with low tech terrain fixes like sleep, muscle, and insulin control is the prevention model that works. Source: https://www.sciencedaily.com/releases/2025/10/251001092206.htm All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Apple cider vinegar, weight loss myths, NMN supplements, NAD precursors, cellular energy, sleep and dementia, brain aging, deep sleep optimization, REM sleep, psilocybin therapy, BDNF, neuroplasticity, pain relief, mood reset, AI cancer detection, early cancer screening, biohacking news, longevity science, Dave Asprey, Human Upgrade podcast Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction 0:18 — Story 1: Apple Cider Vinegar and Weight Loss 1:49 — Story 2: NMN is Back in Supplements 3:31 — Story 3: Sleep and Brain Health 5:39 — Story 4: Psilocybin and Lasting Relief 7:49 — Story 5: AI Tool DOLPHIN for Early Cancer Signals 9:48 — Conclusion & Weekly Roundup See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.