Podcasts about science letters

TWiV explains why RFK Jr.'s proposal to let H5N1 infections in birds ‘rip' is a bad idea, phase 1/2 trial of combined influenza/COVID mRNA vaccines, and how your first influenza virus exposure shapes the B cell response to influenza vaccination 50 years later. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 RFK Jr. says let H5N1 rip through flocks (NY Times) Combined flu/COVID mRNA vaccine (Nat Comm) Rare syndrome after COVID vaccination (NY Times, medRxiv) Imprinting lasts 50 years (Immunity) Imprinting protects against H5N1 and H7N9 (Science) Letters read on TWiV 1203 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – Node-Focal Plane Image Competition Rich – Periodic cooking of eggs Vincent – The use of placebo controls in clinical trials Listener Picks Anne – Everything is Tuberculosis by John Green Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiV discusses secret anti-vax campaign run by Pentagon to undermine China during pandemic, NY governor's subways mask ban proposal, Colorado bat facility sparks outbreak fears, House budget billls suggest ban on gain of function research, evolution of STAT2 resistance to flavivirus NS5, and brainwide silencing of prion protein by AAV-mediated delivery of an epigenetic editor. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Pentagan anti-vac campaign to undermine China (Reuters) NY governor subway mask ban (AP News) Colorado bat facility sparks outbreak fears (Science) House NIH budget bans gain of function research (Science) Evolution of STAT2 resistance to flavivirus NS5 (Nat Commun) Brainwide silencing of prion protein by AAV delivered epigenetic editor (Science) Letters read on TWiV 1127 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Mars Odyssey Orbiter is about to make its 100,000th orbit Alan – Local animal shelters and “kitten season.” Vincent – Supreme Court allows cities to ban homeless people sleeping outside, even when shelter space is lacking Listener Picks Blog design – Trump vows to defund schools requiring vaccines for students Jon – Detections of highly pathogenic avian influenza in mammals Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiP solves the case of the case of the boy in Uganda with a mobile piece of spaghetti in the gallbladder, and reviews papers on female genital schistosomiasis in rural Madagascar, and a volatile sex attractant of tsetse flies. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode •Female genital schistosomiasis in rural Madagascar (PLoS NTD) •A volatile sex attractant of tsetse flies (Science) •Letters read on TWiP 215 Become a patron of TWiP Case Study for TWiP 215 This case was shared with my by a former student of the Diploma in Tropical Medicine and Hygiene course I coordinate, Prof Eyal Leshem, who is the Director  of the Institute for Travel and Tropical Medicine at the Sheba Medical Center in Tel Aviv and Clinical Associate Professor at the School of Medicine at Tel Aviv University, Israel. This case is of a 24 year old male who presented to the emergency room at the end of February with a 4 day history of fever, starting three weeks after he returned from a long trip. He reports traveling in India during October of the past year. From November to early January, he stayed in Papua New Guinea, from where he traveled to Thailand, returning to Israel in early February. On admission he reports a daily fever up to 40 degrees C, which I think is 104 Fahrenheit. He also mentions an itchy rash and dry cough. We learn a bit more about this patient. In Thailand, he received a five-day course of doxycycline due to a febrile illness, which resolved after treatment. During his stay in Papua New Guinea he hiked in the jungle, was bitten by multiple insects and also report finding leeches attached to his lower legs. One insect bite on his hip took a while to heal. He also reports swimming in multiple rivers. While travelling, he did not have unprotected sexual encounters but he admits to eating street food and home made food regularly. He received pre-travel vaccines and when he was in Papua New Guinea took Atovaquone Proguanil prophylaxis daily, discontinuing therapy a week after he flew to Thailand. On physical exam he is alert and oriented, vitals normal, the examination is unremarkable except for three cropped vesicles on his penis, which the patients says are itchy. A healed insect bite on his lower hip is also noted. His white blood count and differential are normal without eosinophilia. His haemoglobin is 13 g/dl, which is borderline normal and his platelet count is lower than normal with a count of 100,000 per microlitre of blood. What is your diagnosis? What test or tests would you like to order to confirm your suspicion. We would like you to be as accurate as you can when identifying the parasite causing this man's symptoms. What are special considerations you need to think about for treatment? Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Cedric Feschotte and John Anthony Frank Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Cedric on TWiV 935 Antiviral retroviral protein (Science) Stealing genes, facing consequences (Science) Letters read on TWiV 956 Timestamps by Jolene. Thanks! Weekly Picks Kathy – Wastewater Dashboard Rich – Artemis I Mission;  Artemis I launch; Artemis I Map Vincent – Pasta Grammar Listener Picks Rich – Watch a virus in the moments before it attacks Justin – Respiratory syncytial virus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 vaccines for children (Science) Risk of infection with variants (medRxiv) Immune correlates of mRNA-1273 (Science) Letters read on TWiV 835 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Pee Wee Herman aka Paul Rubens Brianne – APOD: Pleiades Vincent – A History of Poliomyelitis by JR Paul Listener Picks Richard – Let's talk about a familiar problem and a new tactic…. Sherri – Have the New Jab Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 vaccines for children (Science) Risk of infection with variants (medRxiv) Immune correlates of mRNA-1273 (Science) Letters read on TWiV 835 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Pee Wee Herman aka Paul Rubens Brianne – APOD: Pleiades Vincent – A History of Poliomyelitis by JR Paul Listener Picks Richard – Let's talk about a familiar problem and a new tactic…. Sherri – Have the New Jab Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode mRNA vaccine boosts cross-variant neutralizing Ab (Science) mRNA vaccine boosts variant B and T cell responses (Science) Directed evolution of virus-like nucleocapsid (Science) Letters read on TWiV 779 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Science of Chocolate Chip Cookies Alan – Keeping Black students in STEM Vincent – Antiviral Program for Pandemics Listener Pick Mark – Curator on the Loose, Classic Airliners and Vintage Pop Culture, Flying Men, Flying Machines, Thai Flying Club Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews evidence that mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode mRNA vaccine boosts cross-variant neutralizing Ab (Science) mRNA vaccine boosts variant B and T cell responses (Science) Directed evolution of virus-like nucleocapsid (Science) Letters read on TWiV 779 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Science of Chocolate Chip Cookies Alan – Keeping Black students in STEM Vincent – Antiviral Program for Pandemics Listener Pick Mark – Curator on the Loose, Classic Airliners and Vintage Pop Culture, Flying Men, Flying Machines, Thai Flying Club Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode David Kessler to head Operation Warp Speed (NY Times) Phase 1/2 results of Sinovac inactivated vaccine (Lancet) beta-propiolactone (Wikipedia) Multivalent anti-SARS-CoV-2 nanobodies (Science) Letters read on TWiV 708 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Photos of mob attacking Capitol Brianne – Video of Neutrophil Phagocytosis Alan – Fishing Through the Apocalypse Rich – A Word on Statistics by Wislawa Szymborska Vincent – Letters from an American Listener Pick Mike – Have the new jab Intro music is by Ronald Jenkees

The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode David Kessler to head Operation Warp Speed (NY Times) Phase 1/2 results of Sinovac inactivated vaccine (Lancet) beta-propiolactone (Wikipedia) Multivalent anti-SARS-CoV-2 nanobodies (Science) Letters read on TWiV 708 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Photos of mob attacking Capitol Brianne – Video of Neutrophil Phagocytosis Alan – Fishing Through the Apocalypse Rich – A Word on Statistics by Wislawa Szymborska Vincent – Letters from an American Listener Pick Mike – Have the new jab Intro music is by Ronald Jenkees

Podcast: This Week in Virology (LS 62 · TOP 0.5% what is this?)Episode: TWiV 697: The sky is NOT fallingPub date: 2020-12-24TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position 3:39 NERVTAG meeting minutes (pdf) NERVTAG Preliminary genomic characterization of UK variant (virological.org) PHE investigation of UK variant (pdf) N501Y does not affect antibody neutralization (Science, eLife) WHO notice on UK variant (WHO) Liver tumor during AAV gene therapy (Science) Letters read on TWiV 697 Timestamps by Jolene. Thanks! Weekly Picks Brianne – EM Rap Podcast COVID update Kathy – Conjunction of Jupiter and Saturn and Tony Fauci vaccinated Santa Claus Rich – Chicken LIttle (wiki) Vincent – virological.org Listener Pick Greg – Someone who wants to make a difference Uli – XKCD on statistics Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tvThe podcast and artwork embedded on this page are from Vincent Racaniello, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.

TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position 3:39 NERVTAG meeting minutes (pdf) NERVTAG Preliminary genomic characterization of UK variant (virological.org) PHE investigation of UK variant (pdf) N501Y does not affect antibody neutralization (Science, eLife) WHO notice on UK variant (WHO) Liver tumor during AAV gene therapy (Science) Letters read on TWiV 697 Timestamps by Jolene. Thanks! Weekly Picks Brianne – EM Rap Podcast COVID update Kathy – Conjunction of Jupiter and Saturn and Tony Fauci vaccinated Santa Claus Rich – Chicken LIttle (wiki) Vincent – virological.org Listener Pick Greg – Someone who wants to make a difference Uli – XKCD on statistics Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position 3:39 NERVTAG meeting minutes (pdf) NERVTAG Preliminary genomic characterization of UK variant (virological.org) PHE investigation of UK variant (pdf) N501Y does not affect antibody neutralization (Science, eLife) WHO notice on UK variant (WHO) Liver tumor during AAV gene therapy (Science) Letters read on TWiV 697 Timestamps by Jolene. Thanks! Weekly Picks Brianne – EM Rap Podcast COVID update Kathy – Conjunction of Jupiter and Saturn and Tony Fauci vaccinated Santa Claus Rich – Chicken LIttle (wiki) Vincent – virological.org Listener Pick Greg – Someone who wants to make a difference Uli – XKCD on statistics Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Kathleen A. Crowley Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pfizer vaccine efficacy (Pfizer) Pfizer vaccine (Stat) Distribution of Pfizer vaccine (NY Times) LSTMH vaccine tracker SARS-CoV-2 humans to mink and back in Netherlands (Science) SARS-CoV-2 mink isolates in Denmark (pdf) Preexisting antibodies to SARS-CoV-2 in humans (Science) Letters read on TWiV 681 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – OSIRIS-REx | NASA Brianne – Virtual Science Museum Tours Alan – Ring Fit Adventure Rich – BUGSS Baltimore Underground Science Space Vincent – Trilobite glassworks Listener Pick Gina and Joe – COVID Fan Tutte Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Kathleen A. Crowley Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pfizer vaccine efficacy (Pfizer) Pfizer vaccine (Stat) Distribution of Pfizer vaccine (NY Times) LSTMH vaccine tracker SARS-CoV-2 humans to mink and back in Netherlands (Science) SARS-CoV-2 mink isolates in Denmark (pdf) Preexisting antibodies to SARS-CoV-2 in humans (Science) Letters read on TWiV 681 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – OSIRIS-REx | NASA Brianne – Virtual Science Museum Tours Alan – Ring Fit Adventure Rich – BUGSS Baltimore Underground Science Space Vincent – Trilobite glassworks Listener Pick Gina and Joe – COVID Fan Tutte Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guests: Daniel Griffin and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASH guidelines on anticoagulants in COVID-19 patients (ASH) Followup of adults with noncritical COVID-19 (Clin Micr Inf) Tocilizumab in COVID-19 ICU patients (Lancet Rheum) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders 2020 Nobel Prize Chemistry (pdf) Progress towards polio eradication Afghanistan (MMWR) Inborn errors of IFN and serious COVID-19 (Science) Letters read on TWiV 671 Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Coronavirus : A book for children by Kate Wilson and Nia Roberts Alan - Lost Prologue Rich -RAPS COVID-19 vaccine tracker Vincent - A Crack in Creation by Doudna and Sternberg and Sternberg on TWiM 184 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guests: Daniel Griffin and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASH guidelines on anticoagulants in COVID-19 patients (ASH) Followup of adults with noncritical COVID-19 (Clin Micr Inf) Tocilizumab in COVID-19 ICU patients (Lancet Rheum) Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders 2020 Nobel Prize Chemistry (pdf) Progress towards polio eradication Afghanistan (MMWR) Inborn errors of IFN and serious COVID-19 (Science) Letters read on TWiV 671 Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Coronavirus : A book for children by Kate Wilson and Nia Roberts Alan - Lost Prologue Rich -RAPS COVID-19 vaccine tracker Vincent - A Crack in Creation by Doudna and Sternberg and Sternberg on TWiM 184 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CD8 cells defend against SARS-CoV (J Virol) Deep immune profiling of COVID-19 patients (Science) Letters read on Immune 33 Image credit Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Dickson, Daniel and Vincent solve the case of the Wife of a Guy with Cyclospora Diarrhea, and discuss the discovery of an intrinsic oscillator that drives the bloodstream stage cycle of the malaria parasite. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Intrinsic oscillator in malaria parasite (Science) Malaria parasite has intrinsic clock (Science) Letters read on TWiP 185 Become a patron of TWiP Case Study for TWiP 185 Seeing this type of case 1/week for last several weeks. 75 yo female, admitted with fever, body aches, cough, loose stool for 2 week, sodium 118. Sheltering in place in Long Island, some gardening, no travel. Blood testing detected low sodium. COVID-19 negative, no other symptoms. Blood work: wbc 2000; hematocrit 24; platelets 40; sodium 120s. Unremarkable physical exam. Lyme test negative; other tick borne diseases negative. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email. Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Safety of Ad5 vectored COVID-19 vaccine (Lancet) Analysis of hydroxychloroquine use (Lancet) Remdesivir study (NEJM) Ancient COVID-19 history (MMWR) Drug repurposing for COVID-19 (bioRxiv) Why do few COVID-19 patients infect others? (Science) Overdispersion in COVID-19 transmission (Wellcome Open Res) Reducing airborne transmission (Science) Letters read on TWiV 621 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email. Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Safety of Ad5 vectored COVID-19 vaccine (Lancet) Analysis of hydroxychloroquine use (Lancet) Remdesivir study (NEJM) Ancient COVID-19 history (MMWR) Drug repurposing for COVID-19 (bioRxiv) Why do few COVID-19 patients infect others? (Science) Overdispersion in COVID-19 transmission (Wellcome Open Res) Reducing airborne transmission (Science) Letters read on TWiV 621 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Inactivated SARS-CoV-2 vaccine protects monkeys (bioRxiv) Saliva is more sensitve than nasopharyngeal swab (medRxiv) NY serological survey results (NY Times) FDA caveats on serological tests (FDA) Federal guidelines on when to open When to open: Roadmap, blog, video explainer Blocking TMPRSS2 blocks SARS-CoV-2 infection (Cell) Lawmakers want human challenge studies (Science) Letters read on TWiV 606 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Inactivated SARS-CoV-2 vaccine protects monkeys (bioRxiv) Saliva is more sensitve than nasopharyngeal swab (medRxiv) NY serological survey results (NY Times) FDA caveats on serological tests (FDA) Federal guidelines on when to open When to open: Roadmap, blog, video explainer Blocking TMPRSS2 blocks SARS-CoV-2 infection (Cell) Lawmakers want human challenge studies (Science) Letters read on TWiV 606 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Dickson, Daniel and Vincent solve the case of the Two Volunteers With Watery Diarrhea, discuss diagnosis of SARS-CoV-2 in the New York area, and reveal an approach to preventing honeybee colony collapse by imbuing their gut bacteria with the ability to produce antiviral and antiparasite double-stranded RNAs. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media: Facebook, Instagram, Twitter Daniel on TWiV Special Engineered symbionts limit honeybee pathogens (Science) Letters read on TWiP 181 Become a patron of TWiP. Case Study for TWiP 181 Risks of being helpful. Volunteer from previous case. Diarrhea is gone, now has second issue. Since coming to Uganda noticing on waking in AM often has series of 1 cm red raised lesions in a line, 3-4, on torso. Swollen and itchy. New ones in the AM. Manager says welcome to Uganda. They move out of room, leave bedding behind. Lesions stop. What is going on and when can they move back into room? Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

The TWiP professors solve the case of the Ugandan Child with Splenomegaly, and reveal that mutations in the P. falciparum genome that confer artemisinin resistance interfere with endocytic uptake of hemoglobin. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media: Facebook, Instagram, Twitter Endocytosis pathway mediates artemisinin resistance in malaria parasites (Science) Letters read on TWiP 180 Become a patron of TWiP. Case Study for TWiP 180 Uganda with a twist. Meets two people with watery diarrhea, 12 episodes/day, loss of appetite. No fever, no blood in stool. Living for months at staff guest house. One week prior to onset went on weekend trip to area with waterfalls. Were served outdoor meal: meat, salad, fruit. Recommends empiric treatment trimethoprim/sulfamethoxzole for 7 days. Prompt resolution of diarrhea. A few days later, upon drinking coffee with milk gets severe cramps. 20s, long term female volunteers.  Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction. Hosts: Ori Lieberman, Erin Calipari,Jason Shepherd, and Vincent Racaniello Click arrow to play Download TWiN 003 (52 MB .mp3, 86 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Dopamine neurons encode reward probability and uncertainty (Science) Letters read on TWiN #3 Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv

The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Evolutionary historyof RNA viruses (Nature) The amphioxus song Norovirus tropism for tuft cells(Science) Letters readon TWiV 491 Weekly Science Picks Alan - Oligodendroglioma in song Kathy- Everything-repellent coating to grime proof phone screens & more Rich- Gaia star map Dickson- Clouds are complicated Vincent - Eradicating polio with a vaccine we must stop using Listener Pick Stephen- Forget the Avengers, it took real heroes to make India polio-free Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiM team explores a stingless bee that requires a fungal steroid to pupate, and colonic biofilms containing tumorigenic bacteria in patients with colorectal polyps. Hosts:  Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a patron of TWiM. Links for this episode Bee larvae require fungal steroid to pupate (Sci Rep) Biofilm refuge for tumorigenic bacteria (Science) Letters read on TWiM 171 Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

The TWiPians solve the case of the Woman With Anemia, Eosinophila, and a Worm in Her Intestine, and discuss a study on the function and druggability of two malarial aspartate proteases. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Malaria plasmepsins involved in invasion and egress (Science) Letters read on TWiP 143 Case Study for TWiP 143 From 1990s seen by a colleague, boy late teens, initially presented to ER in US chief complaint, visual disturbances and itching preventing sleep. Immigrated from Oaxaca, searching for work. Lived in modest dwelling with dirt floors, no running water, got from local river. Reports dogs, farm animals, many insects. On exam: tender nodules on head, skin irritated from scratching, small punctate lesions on right cornea. Is referred to specialists. Ophthalmologist called in, referred for further diagnostics. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Guest: Lynda Coughlan   Become a patron of TWiV! Links for this episode Linda on Virus Watch and BSGCT Anti-influenza peptide from frogs (Immunity) Magainins (Wikipedia) Urumi Kathy's defensin paper (PLoS Path) World Hepatitis Day Mouse model for hepacivirus infection (Science) Letters read on TWiV 452 Weekly Science Picks Kathy - US rivers as subway map Lynda - No Time to Lose: A Life in Pursuit of Deadly Viruses by Peter Piot Alan - Apollo-era computers found in dead engineer’s basement Vincent - 110 NFL Brains, research article in JAMA and The best science is often accidental Listener Pick Stig - Security Now! and The Gene by Siddhartha Mukherjee Ricardo - John Oliver on Vaccines Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter. The microbophiles investigate the ratio of bacterial to human cells in our bodies, and how placing solar panels on a bacterium enables it to carry out photosynthesis. Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode  Revised estimates of human and bacterial cells in the body (biorxiv) Power of ten (Small Things Considered) Solar-to-chemical production in bacteria (Science) Letters read on TWiM 119 This episode is sponsored by ASM Grant Writing Institute Online Webinar and 32nd Clinical Virology Symposium Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv. Thumbnail image: Cell structure of a gram positive bacterium. This vector image is completely made by Ali Zifan - Own work; used information from Biology 10e Textbook (chapter 4, Pg: 63) by: Peter Raven, Kenneth Mason, Jonathan Losos, Susan Singer · McGraw-Hill Education.  

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants. This episode is sponsored by ASM Microbe and ICAAC/ICC Links for this episode Possible sexual transmission of Ebolavirus (MMWR) Ebolavirus whole-virus vaccine protects primates (Science) Biologically contained Ebolaviruses (PNAS) Ebolavirus is evolving but not changing (Virology) Ebolavirus not undergoing rapid evolution (Science) Letters read on TWiV 335 Timestamps by Jennifer. Thank you! Weekly Science Picks Alan - PinboardRich - Academic medicine investment in medical researchKathy - Tissue paper stop motion animationDickson - Do peer review panels select best science proposals?Vincent - MMR and autism: Still no association Listener Pick of the Week Ramon - Autism by MMR vaccine statusMehul -  Ebolavirus disease courseJustin - Molecular Biology of Bacterial Viruses by Gunther S. Stent Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Hruby and Yoshihiro Kawaoka Vincent and Rich discuss avian influenza virus and an antiviral drug against smallpox with Dennis and Yoshi at the ASM Biodefense and Emerging Diseases Research Meeting in Washington, DC. Links for this episode ASM Biodefense Meeting Influenza H5N1 transmission (Virus Res) Aerosol transmission of H5N1 virus in ferrets (Nature) Characterization of H7N9 virus from humans (Nature) ST-246 efficacy in primates (AAC) Antiviral options for biodefense (Curr Op Virol) ST-246 safety in humans (Antimicrob Agents Chemother) Gain-of-function experiments (Science) Letters read on TWiV 270 Video of this episode - view at Vimeo Weekly Science Picks Vincent - Quanta MagazineRich - Colour is in the eye of the beholder Listener Pick of the Week Kehau - Beautiful but deadly viruses Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Ashlee Bennett Vincent, Alan, Kathy, and Ashlee discuss fomites in physicians offices, plant virus factories involved in aphid transmission, and clues from the bat genome about flight and immunity. Links for this episode How viruses cause disease (Coursera) How clean is your iPad (Which?) Meeting announcement: From emerging to pandemic viruses CaMV virus factories involved in aphid transmission (J Virol) Caulimovirus (ViralZone) CaMV responds instantly to vector (eLIFE) Aphid acquiring CaMV (J Virol) Bat genomes, flight, and immunity (Science) Letters read on TWiV 268 Weekly Science Picks Kathy - Jean-Luc Doumont (slides, communicating science, website, Scitable)Alan - Wireless thermometerVincent - LORiOLA viral necklaces Listener Pick of the Week Jessica - Knit icosahedronRobert - Practical computing for biologists by Haddock and DunnStephen - Fourteen years of US weather (YouTube) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy discuss finding viruses in outer space, varying results obtained from personal genetic testing, and depletion of CD4 cells during HIV infection by pyroptosis. Links for this episode We should hunt for viruses in space (New Scientist) I had my DNA picture taken (NY Times) CD4 cell death by pyroptosis (Nature) Abortive HIV infection in lymphoid tissue (Cell) IFI16 sensor required for HIV mediated cell death (Science) PubMed Commons Preferential CTL targeting of Gag (Cell Rep) Exonic transcription protein binding (Science) Letters read on TWiV 266 Video of this episode - view at YouTube Weekly Science Picks Kathy - 17 mundane things, mind blowing viewsAlan - SnowovelVincent - Public's views on human evolution Listener Pick of the Week Emily - Dengue pillow  Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Michelle Swanson. Vincent and Michelle reveal how the human gut microbiota can modulate obesity in mice. Links for this episode:  Gut microbiota modulate metabolism (Science)  Fighting obesity with bacteria (Science) Letters read on TWiM 065 Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

Vincent and Dickson review how sickle cell microRNAs contribute to malaria resistance, and inhibition of innate immune responses by an enzyme from trypanosomes. Links for this episode: microRNAs involved in sickle cell resistance to Plasmodium (Cell Host Microbe) Trypanosome adenylate cyclases modulate innate immune response (Science) Letters read on TWiP 43 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv.