Podcasts about allergy and clinical immunology

Guest: Jordan Orange, MD, PhD Guest: Joshua Milner, MD Guest: Eric Silver, MD Guest: Steven Lobritto, MD On this episode of Advances in Care, host Erin Welsh explores the story behind the GUARDIAN study, where thousands of newborn babies have been screened against rare disease by sequencing their genes, and looking for more conditions than any of the current standard screening panels. First, she hears from Dr. Jordan Orange, Physician-in-Chief at Morgan Stanley Children's Hospital at NewYork-Presbyterian and Columbia, about why genetic testing is a promising way of not only catching treatable rare diseases in infants, but also expanding health equity and medical resources to marginalized populations. Erin also hears from Dr. Josh Milner, a pediatric immunologist who treated a patient with a rare form of SCID, or severe combined immune deficiency, also known as bubble boy disease that was detected in the GUARDIAN screening panel. SCID is a disease that typically occurs in 1 of 50,000 babies. But GUARDIAN caught two cases within the first 10,000 babies involved in the program, indicating that the rate of the disease might be higher than expected, and that the most accurate way to detect is through genetic screening. Dr. Steven Lobritto, a pediatric gastroenterologist, also weighs in on how genetic screening can help identify Wilson's disease, a copper storage …

CME credits: 0.50 Valid until: 28-02-2026 Claim your CME credit at https://reachmd.com/programs/cme/accurate-diagnosis-and-management-of-hereditary-alpha-tryptasemia/32716/ The identification of KIT D816V mutation as a key driver for the expansion and accumulation of neoplastic mast cells in systemic mastocytosis (SM) has significantly improved the diagnosis, subclassification, and management of SM. Moreover, the advent of novel targeted therapies has dramatically changed the treatment landscape. However, challenges persist for community clinicians due to the low prevalence of SM and its vague and wide spectrum of clinical features. Expanded knowledge of the recommended pathology and laboratory evaluation for the diagnosis and subclassification of the disease is needed to shorten delays in diagnosis and delivery of optimal care. Tune in and find out more about the management of SM and the latest clinical evidence and guideline recommendations for the use of tyrosine kinase inhibitors (TKIs) and learn about the role played by pathologists in the identification and diagnosis of SM, which ultimately guides treatment selection.

CME credits: 0.50 Valid until: 28-02-2026 Claim your CME credit at https://reachmd.com/programs/cme/diagnosis-and-treatment-of-systemic-mastocytosis-with-an-associated-hematologic-neoplasm/32715/ The identification of KIT D816V mutation as a key driver for the expansion and accumulation of neoplastic mast cells in systemic mastocytosis (SM) has significantly improved the diagnosis, subclassification, and management of SM. Moreover, the advent of novel targeted therapies has dramatically changed the treatment landscape. However, challenges persist for community clinicians due to the low prevalence of SM and its vague and wide spectrum of clinical features. Expanded knowledge of the recommended pathology and laboratory evaluation for the diagnosis and subclassification of the disease is needed to shorten delays in diagnosis and delivery of optimal care. Tune in and find out more about the management of SM and the latest clinical evidence and guideline recommendations for the use of tyrosine kinase inhibitors (TKIs) and learn about the role played by pathologists in the identification and diagnosis of SM, which ultimately guides treatment selection.

CME credits: 0.50 Valid until: 28-02-2026 Claim your CME credit at https://reachmd.com/programs/cme/is-it-nonresponsiveprogressive-ism/32714/ The identification of KIT D816V mutation as a key driver for the expansion and accumulation of neoplastic mast cells in systemic mastocytosis (SM) has significantly improved the diagnosis, subclassification, and management of SM. Moreover, the advent of novel targeted therapies has dramatically changed the treatment landscape. However, challenges persist for community clinicians due to the low prevalence of SM and its vague and wide spectrum of clinical features. Expanded knowledge of the recommended pathology and laboratory evaluation for the diagnosis and subclassification of the disease is needed to shorten delays in diagnosis and delivery of optimal care. Tune in and find out more about the management of SM and the latest clinical evidence and guideline recommendations for the use of tyrosine kinase inhibitors (TKIs) and learn about the role played by pathologists in the identification and diagnosis of SM, which ultimately guides treatment selection.

CME credits: 0.50 Valid until: 28-02-2026 Claim your CME credit at https://reachmd.com/programs/cme/differential-diagnosis-of-indolent-systemic-mastocytosis/32713/ The identification of KIT D816V mutation as a key driver for the expansion and accumulation of neoplastic mast cells in systemic mastocytosis (SM) has significantly improved the diagnosis, subclassification, and management of SM. Moreover, the advent of novel targeted therapies has dramatically changed the treatment landscape. However, challenges persist for community clinicians due to the low prevalence of SM and its vague and wide spectrum of clinical features. Expanded knowledge of the recommended pathology and laboratory evaluation for the diagnosis and subclassification of the disease is needed to shorten delays in diagnosis and delivery of optimal care. Tune in and find out more about the management of SM and the latest clinical evidence and guideline recommendations for the use of tyrosine kinase inhibitors (TKIs) and learn about the role played by pathologists in the identification and diagnosis of SM, which ultimately guides treatment selection.

Guest: Kathleen M. Buchheit, MD Guest: Joseph K. Han, MD Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with a low quality of life and increased healthcare utilization,1,2 and patients often continue to have severe symptoms despite therapy.​3 Understanding the role of underlying inflammatory pathways and epithelial dysfunction may help inform clinical decision making for these patients.​3,4 In this program, Dr Kathleen Buchheit and Dr Joseph Han share their insights on the pathophysiology of CRSwNP and how unaddressed underlying inflammation may contribute to a variety of challenges for patients. Dr Buchheit is an Assistant Professor of Medicine at Harvard Medical School, specializing in Allergy and Immunology. Dr Han is a Professor of Otolaryngology, the Chief for the Division of Rhinology and Endoscopic Sinus and Skull Base Surgery, and the Chief of the Division of Allergy at Eastern Virginia Medical School in Norfolk, Virginia. References: Mullol J, et al. J Allergy Clin Immunol Pract. 2022;10:1434-1453.e9 Bhattacharyya N, et al. Laryngoscope. 2019;129:1969-1975. van der Veen J, et al. Allergy. 2017;72:282-290. Laidlaw TM, et al. J Allergy Clin Immunol Pract. 2021;9:1133-1141. ©2024 Amgen and AstraZeneca. All rights reserved.US-96000 Last Updated 12/24

In this brief video, learn more about growing evidence supporting the key role of airway epithelium dysfunction in driving inflammation in CRSwNP. ©2025 Amgen and AstraZeneca. All rights reserved.US-94728 Last Updated 1/25

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Stephen I. Pelton, MD In the last two pre-pandemic flu seasons, approximately half of hospitalizations from influenza in the US were in adults 65 and older.1,2 A recent real-world study evaluated the relative effectiveness of adjuvanted influenza vaccine versus high-dose vaccine in preventing test-confirmed influenza hospitalizations in this age group across three flu seasons between 2017 and 2020.3 Dr. Charles Turck sits down with Dr. Stephen Pelton, an author on this study, to explore the findings and their implications for influenza vaccination strategies in older adults. Dr. Pelton is a Professor of Pediatrics at the Boston University Chobanian and Avedisian School of Medicine. References: Pelton SI, Nguyen VH, Mould-Quevedo JF. The value of influenza vaccination in the older adult population. A stochastic model estimation of the benefit of vaccination to prevent the severe outcomes in the U.S. Poster presented at: IDWeek 2023; October 11-15; Boston, MA. Pelton SI, Mould-Quevedo JF, Nguyen VH. The impact of adjuvanted influenza vaccine on disease severity in the US: a stochastic model. Vaccines. 2023;11:1525. McGovern I, Chastek B, Bancroft T, et al. Relative vaccine effectiveness of MF59-adjuvanted vs high-dose trivalent inactivated influenza vaccines for prevention of test-confirmed influenza hospitalizations during the 2017-2020 influenza seasons. Int J Infect Dis. …

Guest: Ryan Maves, MD Guest: Susan Corbridge, PhD, APRN, ACNP-BC, FAANP, FCCP, FAAN Although there have been several advances in vaccine technology and safety the past few years, the prevalence of vaccine hesitancy among patients is increasing. Since vaccine hesitancy heightens the burden of potentially life-threatening viruses like RSV and influenza, Dr. Ryan Maves speaks with Dr. Susan Corbridge about why patients might be reluctant to get vaccinated and how we can use the First 5 Minutes approach to provide individualized counseling on the importance of vaccines. Dr. Maves is a Professor of Medicine and Anesthesiology in the Sections of Infectious Diseases and Critical Care Medicine at the Wake Forest University School of Medicine, and Dr. Corbridge is a Professor Emerita at the University of Illinois at Chicago College of Nursing. This episode is supported by an educational grant from Moderna.

Guest: Lillian Siu, MD, FRCPC With a few studies in the works for cancer vaccines, the future is exciting for what this could mean for oncology patients. Dive in to learn about the various ways to package cancer vaccines so they can be delivered to patients effectively. And to learn more about the limitations, targets, and platforms of cancer vaccines, which was the topic of her presentation at the American Society of Clinical Oncology 2024 Conference, hear from Dr. Lillian Siu, Senior Medical Oncologist at the Princess Margaret Cancer Centre and Professor of Medicine at the University of Toronto.

Guest: Lillian Siu, MD, FRCPC Since cancer vaccines have been of interest to oncologists for decades, they've been trying to figure out how to prime or stimulate the immune system to attack cancer, and until the last few years, cancer vaccines have been challenging. To learn about this unique area of study, which she also presented at ASCO 2024, join Dr. Lillian Siu, Senior Medical Oncologist at the Princess Margaret Cancer Centre and a Professor of Medicine at the University of Toronto.

Guest: Lillian Siu, MD, FRCPC With a few studies in the works for cancer vaccines, the future is exciting for what this could mean for oncology patients. Dive in to learn about the various ways to package cancer vaccines so they can be delivered to patients effectively. And to learn more about the limitations, targets, and platforms of cancer vaccines, which was the topic of her presentation at the American Society of Clinical Oncology 2024 Conference, hear from Dr. Lillian Siu, Senior Medical Oncologist at the Princess Margaret Cancer Centre and Professor of Medicine at the University of Toronto.

Guest: Lillian Siu, MD, FRCPC Since cancer vaccines have been of interest to oncologists for decades, they've been trying to figure out how to prime or stimulate the immune system to attack cancer, and until the last few years, cancer vaccines have been challenging. To learn about this unique area of study, which she also presented at ASCO 2024, join Dr. Lillian Siu, Senior Medical Oncologist at the Princess Margaret Cancer Centre and a Professor of Medicine at the University of Toronto.

CME credits: 1.00 Valid until: 29-05-2025 Claim your CME credit at https://reachmd.com/programs/cme/you-dont-know-whim-syndrome-a-chronic-neutropenic-disorder/24547/ WHIM syndrome is a rare, inherited, combined immunodeficiency disease caused by reduced mobilization and trafficking of white blood cells from the bone marrow due to over-signaling of the CXCR4/CXCL12 pathway. WHIM syndrome is named for its four common clinical findings. The diagnostic challenges arise because not all symptoms are required for a diagnosis and all of them do not appear at the same time. Patients have deficient blood levels of neutrophils (neutropenia) and lymphocytes (lymphopenia), which results in frequent, recurrent infections. Affected individuals are particularly susceptible to human papillomavirus (HPV), which can cause skin and genital warts and potentially lead to certain types of cancer. Our program goal is to identify risk factors associated with WHIM syndrome, focusing on making an earlier diagnosis that can impact long-term outcomes, timely treatment options and ultimately improved quality of life for patients.

CME credits: 1.00 Valid until: 29-05-2025 Claim your CME credit at https://reachmd.com/programs/cme/goals-of-therapy-for-whim-syndrome-a-chronic-neutropenic-disorder/24552/ WHIM syndrome is a rare, inherited, combined immunodeficiency disease caused by reduced mobilization and trafficking of white blood cells from the bone marrow due to over-signaling of the CXCR4/CXCL12 pathway. WHIM syndrome is named for its four common clinical findings. The diagnostic challenges arise because not all symptoms are required for a diagnosis and all of them do not appear at the same time. Patients have deficient blood levels of neutrophils (neutropenia) and lymphocytes (lymphopenia), which results in frequent, recurrent infections. Affected individuals are particularly susceptible to human papillomavirus (HPV), which can cause skin and genital warts and potentially lead to certain types of cancer. Our program goal is to identify risk factors associated with WHIM syndrome, focusing on making an earlier diagnosis that can impact long-term outcomes, timely treatment options and ultimately improved quality of life for patients.

CME credits: 1.00 Valid until: 29-05-2025 Claim your CME credit at https://reachmd.com/programs/cme/whim-syndrome-and-cxcr4-variants-new-insights-into-cellular-changes-that-can-impact-patient-treatment-plans/24548/ WHIM syndrome is a rare, inherited, combined immunodeficiency disease caused by reduced mobilization and trafficking of white blood cells from the bone marrow due to over-signaling of the CXCR4/CXCL12 pathway. WHIM syndrome is named for its four common clinical findings. The diagnostic challenges arise because not all symptoms are required for a diagnosis and all of them do not appear at the same time. Patients have deficient blood levels of neutrophils (neutropenia) and lymphocytes (lymphopenia), which results in frequent, recurrent infections. Affected individuals are particularly susceptible to human papillomavirus (HPV), which can cause skin and genital warts and potentially lead to certain types of cancer. Our program goal is to identify risk factors associated with WHIM syndrome, focusing on making an earlier diagnosis that can impact long-term outcomes, timely treatment options and ultimately improved quality of life for patients.

CME credits: 1.00 Valid until: 29-05-2025 Claim your CME credit at https://reachmd.com/programs/cme/whim-syndrome-a-misguided-immune-system/24549/ WHIM syndrome is a rare, inherited, combined immunodeficiency disease caused by reduced mobilization and trafficking of white blood cells from the bone marrow due to over-signaling of the CXCR4/CXCL12 pathway. WHIM syndrome is named for its four common clinical findings. The diagnostic challenges arise because not all symptoms are required for a diagnosis and all of them do not appear at the same time. Patients have deficient blood levels of neutrophils (neutropenia) and lymphocytes (lymphopenia), which results in frequent, recurrent infections. Affected individuals are particularly susceptible to human papillomavirus (HPV), which can cause skin and genital warts and potentially lead to certain types of cancer. Our program goal is to identify risk factors associated with WHIM syndrome, focusing on making an earlier diagnosis that can impact long-term outcomes, timely treatment options and ultimately improved quality of life for patients.

CME credits: 1.00 Valid until: 29-05-2025 Claim your CME credit at https://reachmd.com/programs/cme/whim-syndrome-treatment-we-can-do-better/24550/ WHIM syndrome is a rare, inherited, combined immunodeficiency disease caused by reduced mobilization and trafficking of white blood cells from the bone marrow due to over-signaling of the CXCR4/CXCL12 pathway. WHIM syndrome is named for its four common clinical findings. The diagnostic challenges arise because not all symptoms are required for a diagnosis and all of them do not appear at the same time. Patients have deficient blood levels of neutrophils (neutropenia) and lymphocytes (lymphopenia), which results in frequent, recurrent infections. Affected individuals are particularly susceptible to human papillomavirus (HPV), which can cause skin and genital warts and potentially lead to certain types of cancer. Our program goal is to identify risk factors associated with WHIM syndrome, focusing on making an earlier diagnosis that can impact long-term outcomes, timely treatment options and ultimately improved quality of life for patients.

CME credits: 1.00 Valid until: 29-05-2025 Claim your CME credit at https://reachmd.com/programs/cme/whim-syndrome-a-chronic-neutropenic-disorder/24551/ WHIM syndrome is a rare, inherited, combined immunodeficiency disease caused by reduced mobilization and trafficking of white blood cells from the bone marrow due to over-signaling of the CXCR4/CXCL12 pathway. WHIM syndrome is named for its four common clinical findings. The diagnostic challenges arise because not all symptoms are required for a diagnosis and all of them do not appear at the same time. Patients have deficient blood levels of neutrophils (neutropenia) and lymphocytes (lymphopenia), which results in frequent, recurrent infections. Affected individuals are particularly susceptible to human papillomavirus (HPV), which can cause skin and genital warts and potentially lead to certain types of cancer. Our program goal is to identify risk factors associated with WHIM syndrome, focusing on making an earlier diagnosis that can impact long-term outcomes, timely treatment options and ultimately improved quality of life for patients.

CME credits: 1.00 Valid until: 29-05-2025 Claim your CME credit at https://reachmd.com/programs/cme/whim-syndrome-management-the-first-fda-approval-for-patients/24553/ WHIM syndrome is a rare, inherited, combined immunodeficiency disease caused by reduced mobilization and trafficking of white blood cells from the bone marrow due to over-signaling of the CXCR4/CXCL12 pathway. WHIM syndrome is named for its four common clinical findings. The diagnostic challenges arise because not all symptoms are required for a diagnosis and all of them do not appear at the same time. Patients have deficient blood levels of neutrophils (neutropenia) and lymphocytes (lymphopenia), which results in frequent, recurrent infections. Affected individuals are particularly susceptible to human papillomavirus (HPV), which can cause skin and genital warts and potentially lead to certain types of cancer. Our program goal is to identify risk factors associated with WHIM syndrome, focusing on making an earlier diagnosis that can impact long-term outcomes, timely treatment options and ultimately improved quality of life for patients.

Guest: Adam Narloch Guest: Michelle Hermiston, MD, PhD Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH) and advances in understanding this rare disease. Dr Hermiston is a pediatric hematologist-oncologist, a bone marrow transplant specialist, and the Director of the Pediatric Immunotherapy Program at UCSF Benioff Children's Hospital. Join us as we start our journey into the world of HLH! © 2024 Sobi, Inc. All Rights Reserved. NP-34329 04/24

Guest: Adam Narloch Guest: Michelle Hermiston, MD, PhD Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH) and advances in understanding this rare disease. Dr Hermiston is a pediatric hematologist-oncologist, a bone marrow transplant specialist, and the Director of the Pediatric Immunotherapy Program at UCSF Benioff Children's Hospital. Join us as we start our journey into the world of HLH! © 2024 Sobi, Inc. All Rights Reserved. NP-34329 04/24

CME credits: 0.50 Valid until: 24-04-2025 Claim your CME credit at https://reachmd.com/programs/cme/managing-indolent-systemic-mastocytosis-a-multidisciplinary-case-review/18089/ New tyrosine kinase inhibitor (TKI) treatment options can significantly reduce symptom burden in patients with moderate to severe indolent systemic mastocytosis (ISM). Studies report that systemic mastocytosis and ISM are often undiagnosed for years. Improve your diagnosis and treatment of ISM by tapping into the expertise of a multidisciplinary team, including allergists, gastroenterologists, and hematologists, and increase your awareness of diagnostic criteria, the varied presentations of ISM, and new treatment options that move beyond traditional anti-mediator therapy.=

CME credits: 0.25 Valid until: 24-04-2025 Claim your CME credit at https://reachmd.com/programs/cme/multidisciplinary-approach-to-diagnosing-and-managing-indolent-systemic-mastocytosis-the-changing-landscape/18090/ Patients with indolent systemic mastocytosis frequently report a symptom burden disproportionate to measurable disease burden. Anti-mediator intervention is not always successful in improving the quality of life of these patients. But the treatment landscape is changing. Join Drs. Cem Akin, Daniel DeAngelo, and Matthew Hamilton offer key clinical insights into this changing standard of care for ISM and discuss why allergists, hematologists, and gastroenterologists are at the vanguard of this change.=

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Melanie Dispenza, MD The future therapeutic landscape for food allergy prevention is looking clearer as a drug typically used to treat hematologic malignancies has shown to prevent systemic anaphylaxis to allergens and increase patients' tolerance to peanuts. Along with this, other therapies are also in development for allergy treatment. To learn more, join Dr. Charles Turck as he dives deeper into this study and its findings with Dr. Melanie Dispenza, Assistant Professor of Medicine at Johns Hopkins University School of Medicine.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Arnaud Bourdin, MD, PhD Since many severe asthma patients have been shown to have mucus plugs, it's important to understand the role they plan in severe asthma. Join us as we discuss an exploratory study and the role of mucus plugging in severe asthma with Dr. Charles Turck and Professor Arnaud Bourdin. Professor Bourdin is the Head of Pulmonology at the Arnaud de Villeneuve Hospital in Montpellier, France. TEZSPIRE is a registered trademark of Amgen Inc. and AstraZeneca.©2024 Amgen and AstraZeneca. All rights reserved. US-83499 Last Updated 1/24

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Arnaud Bourdin, MD, PhD Since many severe asthma patients have been shown to have mucus plugs, it's important to understand the role they plan in severe asthma. Join us as we discuss an exploratory study and the role of mucus plugging in severe asthma with Dr. Charles Turck and Professor Arnaud Bourdin. Professor Bourdin is the Head of Pulmonology at the Arnaud de Villeneuve Hospital in Montpellier, France. TEZSPIRE is a registered trademark of Amgen Inc. and AstraZeneca.©2024 Amgen and AstraZeneca. All rights reserved. US-83499 Last Updated 1/24

Host: Jennifer Caudle, DO Guest: Sayantani Sindher, MD Recently, Omalizumab was studied in patients due to the avoidance of management and guidance when it comes to treating food allergies in children and adults. According to this doctor, approximately 45 percent of patients seen in his clinic have multi-food allergies that are not being met with current treatment options. So to explain his research, Dr. Jennifer Caudle is joined by Dr. Sayantani Sinder, Clinical Associate Professor of Medicine and Pediatric Allergy and Clinical Immunology Physician at Stanford Healthcare and Stanford Medicine Children's Health.

Host: Tauseef Ali, MD, FACG, AGAF Host: Sabina Ali, MD Host: Neil Nandi, MD, FACP Host: Tina Aswani-Omprakash, MPH A South Asian pediatric gastroenterologist discusses the epidemiology of IBD, distinct phenotypes, the latest clinical data from the mainland and diaspora, patient burden, and the importance of providing culturally competent care.

CME credits: 0.25 Valid until: 16-07-2024 Claim your CME credit at https://reachmd.com/programs/cme/south-asians-with-ibd-underrepresented-and-underappreciated/18122/ A South Asian pediatric gastroenterologist discusses the epidemiology of IBD, distinct phenotypes, the latest clinical data from the mainland and diaspora, patient burden, and the importance of providing culturally competent care.=

Guest: Douglas Jones, MD A recent study was done to show the side effects of diphenhydramine for allergic reactions, and one of the main detriments was that it could impair the patient by making them tired or sleepy. Another finding was that it doesn't work that quickly, so in turn, giving diphenhydramine in a severe allergic reaction could cause more harm than good. To learn more on what you should know before using diphenhydramine in allergic reaction situations and possible better solutions, tune in with Dr. Douglas Jones, Board-Certified Allergist and Immunologist with the Tanner Clinic in Layton, Utah.

Host: Javed Butler, MD, MBA, MPH Guest: Jeffrey Wilson, MD There's a decent amount of evidence showing allergic immune responses could have connections with heart disease. But with the knowledge gaps that exist, a need for bigger cohorts is necessary to get more information and data. So to explore the link between allergic reactions from food and heart disease, Dr. Javed Butler is joined by Dr. Jeffrey Wilson, Allergist and Immunologist in the Department of Medicine's Division of Asthma, Allergy, and Immunology at the University of Virginia.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Arnaud Bourdin, MD, PhD It's only been a recent discovery that mucus plugging may be present and persistent in chronic severe asthma.1 In fact, studies have shown that mucus plugs may drive some lung function deficits in severe asthma.1 Given this recent finding, Dr Charles Turck speaks with Professor Arnaud Bourdin about the clinical significance and pathogenesis of mucus plugging in severe asthma. Professor Bourdin is Head of Pulmonology at Arnaud de Villeneuve Hospital in Montpellier, France. Reference: Dunican EM, Watchorn DC, Fahy JV. Ann Am Thorac Soc. 2018;15(Suppl 3):S184-S191. doi:10.1513/AnnalsATS.201807-485AW ©2024 Amgen and AstraZeneca. All rights reserved. US-86740 Last Updated 3/24

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Arnaud Bourdin, MD, PhD It's only been a recent discovery that mucus plugging may be present and persistent in chronic severe asthma.1 In fact, studies have shown that mucus plugs may drive some lung function deficits in severe asthma.1 Given this recent finding, Dr Charles Turck speaks with Professor Arnaud Bourdin about the clinical significance and pathogenesis of mucus plugging in severe asthma. Professor Bourdin is Head of Pulmonology at Arnaud de Villeneuve Hospital in Montpellier, France. Reference: Dunican EM, Watchorn DC, Fahy JV. Ann Am Thorac Soc. 2018;15(Suppl 3):S184-S191. doi:10.1513/AnnalsATS.201807-485AW ©2024 Amgen and AstraZeneca. All rights reserved. US-86740 Last Updated 3/24

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Basil M. Kahwash, MD Patients with asthma who have experienced challenges with exercise may find that they are hesitant to exercise again in the future, or they may think it's not safe to pursue. However, artificial intelligence (AI) may be a useful tool in promoting exercise in asthma patients due to its ability to generate a personalized approach for the patient with a quick turnaround. Explore the benefits between AI and exercise in asthma patients with Dr. Basil Kahwash, Assistant Professor of Medicine on the Clinical Educator Track in the Department of Medicine at Vanderbilt University in Nashville, Tennessee. He also spoke about this topic at the 2023 Annual ANAC conference in his session, titled “Managing Co-Occurring Conditions: A Clinical Update.”

Guest: Michael T. Pulley, MD PhD The chronic inflammatory demyelinating polyneuropathy (CIDP) treatment objective for disease stabilization and long-term maintenance is to get the patient to a normal functioning state with as few fluctuations and relapses as possible. Dive in with Dr. Qihua Fan, Assistant Professor in the Department of Neurology at Virginia Commonwealth University.

Host: Mary Katherine Cheeley, PharmD, BCPS, CLS, FNLA Guest: Basil M. Kahwash, MD Patients with asthma could benefit greatly from exercising, and over time, it could lead to better asthma control. Dive into this episode to learn more about the findings from a recent study on exercise and asthma with Dr. Mary Katherine Cheeley and Dr. Basil Kahwash, Assistant Professor of Medicine on the Clinical Educator track in the Division of Allergy, Pulmonary, and Critical Care Medicine at Vanderbilt University in Nashville, Tennessee.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Kalpesh Thakkar, MD, MSCR Cow's milk protein allergy is the most common food allergy in infants. And overall, it's important to know that in general, the incidence of allergy is increasing worldwide. To take a deep dive, join Dr. Charles Turck as he speaks with Dr. Kalpesh Thakkar, Pediatric Gastroenterologist at Memorial Hermann Medical Group in Sugarland, Texas. All trademarks are owned by Société des Produits Nestlé S.A., Vevey, Switzerland. ©2023 Nestlé

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Kalpesh Thakkar, MD, MSCR Cow's milk protein allergy is the most common food allergy in infants. And overall, it's important to know that in general, the incidence of allergy is increasing worldwide. To take a deep dive, join Dr. Charles Turck as he speaks with Dr. Kalpesh Thakkar, Pediatric Gastroenterologist at Memorial Hermann Medical Group in Sugarland, Texas. All trademarks are owned by Société des Produits Nestlé S.A., Vevey, Switzerland. ©2023 Nestlé

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Kalpesh Thakkar, MD, MSCR Cow's milk protein allergy is the most common food allergy in infants. And overall, it's important to know that in general, the incidence of allergy is increasing worldwide. To take a deep dive, join Dr. Charles Turck as he speaks with Dr. Kalpesh Thakkar, Pediatric Gastroenterologist at Memorial Hermann Medical Group in Sugarland, Texas. All trademarks are owned by Société des Produits Nestlé S.A., Vevey, Switzerland. ©2023 Nestlé

Guest: Qihua Fan, MD There are three main first-line treatments for CIDP, and those are steroids, immunoglobulins, and plasmapheresis. So to walk us through the updated guidelines, we're joined by Dr. Qihua Fan, Neurology Specialist in the Department of Neurology at Virginia Commonwealth University School of Medicine in Richmond.

Guest: Sami Khella, MD While there are FDA-approved treatments for CIDP, patients remain, to a large extent, fairly disabled by this illness. However, there are several ways in which clinicians can work with their patients to provide the best care possible. Dive in with Dr. Sami Khella, Professor of Clinical Neurology at Penn Medicine University City in Philadelphia.

Host: Jennifer Caudle, DO Guest: David Saperstein, MD When it comes to treating chronic inflammatory demyelinating polyneuropathy (CIDP) with subcutaneous immunoglobulin (SCIG), the patient can be trained by a professional to administer the treatment themselves. So what counseling strategies can we use to help patients successfully transition from intravenous to SCIG therapy? Join Dr. Jennifer Caudle as she gains insights from Dr. David Saperstein, Director of the Center for Complex Neurology, EDS, and POTS in Phoenix, Arizona, and Associate Professor of Clinical Neurology at the University of Arizona College of Medicine.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Jonathan Silverberg, MD, PhD, MPH Atopic dermatitis is more than a disease of the skin. It's a complex and heterogeneous inflammatory disease mediated by multiple T-cell–driven inflammatory pathways, like the OX40 pathway, leading to chronic and persistent symptoms and significant burden.1-4 Explore the heterogeneity of atopic dermatitis and the importance of OX40 signaling in disease pathogenesis with Dr Charles Turck and Dr. Jonathan Silverberg, Professor and Director of Clinical Research and the Director of Patch Testing at George Washington University School of Medicine and Health Sciences. References: Silverberg JI. Clinical Management of Atopic Dermatitis. 1st ed. 2018. Ratchataswan T, et al. J Allergy Clin Immunol Pract. 2021;9:1053-1065. Weidinger S, et al. Nat Rev Dis Primers. 2018;4:1. De Bruyn Carlier T, et al. J Autoimmun. 2021;120:102634. ©2023 Amgen Inc. All rights reserved. USA-451-80031 8/23

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Jonathan Silverberg, MD, PhD, MPH Atopic dermatitis is more than a disease of the skin. It's a complex and heterogeneous inflammatory disease mediated by multiple T-cell–driven inflammatory pathways, like the OX40 pathway, leading to chronic and persistent symptoms and significant burden.1-4 Explore the heterogeneity of atopic dermatitis and the importance of OX40 signaling in disease pathogenesis with Dr Charles Turck and Dr. Jonathan Silverberg, Professor and Director of Clinical Research and the Director of Patch Testing at George Washington University School of Medicine and Health Sciences. References: Silverberg JI. Clinical Management of Atopic Dermatitis. 1st ed. 2018. Ratchataswan T, et al. J Allergy Clin Immunol Pract. 2021;9:1053-1065. Weidinger S, et al. Nat Rev Dis Primers. 2018;4:1. De Bruyn Carlier T, et al. J Autoimmun. 2021;120:102634. ©2023 Amgen Inc. All rights reserved. USA-451-80031 8/23

Guest: Natalia Castillo Almeida, MD Influenza can increase the risk of hospitalization and disease severity, specifically for high-risk patients. Fortunately, the influenza vaccine can help combat this. Join Dr. Natalia Castillo Almeida, an Assistant Professor in the Division of Infectious Diseases at the University of Nebraska School of Medicine, as she shares key data on hospitalization rates and recommendations for vaccination.

CME credits: 1.00 Valid until: 20-06-2024 Claim your CME credit at https://reachmd.com/programs/cme/rationale-for-tyrosine-kinase-inhibitors-in-non-advanced-systemic-mastocytosis/15630/ Non-advanced systemic mastocytosis (nonAdvSM) is poorly understood and likely often overlooked or misdiagnosed. Multiple issues complicate the accurate differential diagnosis of nonAdvSM subtypes. Recent updates for diagnostic criteria, as well as validated assessments and a greater understanding of laboratory findings for this population, are providing practitioners with additional tools for arriving at an accurate diagnosis. Although many therapeutics exist for addressing symptoms of nonAdvSM, those treatments are purely palliative. To date, no disease-modifying drugs have been FDA-approved for treating nonAdvSM. However, therapeutics that are already approved for advanced SM or other indications are being evaluated in the nonAdvSM space. These drugs, particularly KIT inhibitors, have the potential to improve patient outcomes for nonAdvSM. Healthcare providers are in a unique position to improve patient outcomes by becoming experts in diagnosing, assessing, and monitoring patients with nonAdvSM; as well as ensuring access to the latest, most effective treatments. To that end, there is a need to increase disease state awareness and close knowledge gaps around the diagnosis and management of this rare disease.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Osman Mohamed Elfadil, MD Food allergies and malabsorptive conditions limit food options for patients and can lead to malnutrition if alternative sources of nutrition aren't found. So how might peptide-based formulations fit into our management approach for these GI-compromised patients? Joining Dr. Charles Turck to break down how peptide-based formulations work to improve GI tolerance, who might benefit from them, and the latest data from clinical trials is Dr. Osman Mohamed Elfadil, Senior Research Fellow in the Division of Endocrinology, Diabetes, Metabolism, and Nutrition at the Mayo Clinic in Rochester, Minnesota.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Anna Nowak-Wegrzyn, MD Cow's milk protein allergy is one of the most common food allergies in childhood and can have a heavy burden on our young patients and their families. That's why Dr. Charles Turck speaks with Dr. Anna Nowak-Wegrzyn, Director of the Pediatric Allergy Program at Hassenfeld Children's Hospital NYU Langone, about how we can better manage these patients and address their unmet needs.

Editor-in-Chief Michael Schatz, MD, MS, FAAAAI, discusses the evolution of The Journal of Allergy and Clinical Immunology: In Practice over the past decade and offers thoughts on what the next 10 years may hold. This conversation offers way more than just a walk down memory lane.