Podcasts about cytokines

Even if I needed two to three allergy medications. For over 6 years! And looked like something from a horror movie due to my allergies!WAS IT REALLY ALLERGIES - or just symptoms of something else going on? What are allergies? ------------In this episode of BodyHacking – Build a Better You, Michaela opens up about her personal battle with allergies that began after the birth of her second son. From seasonal sniffles to full-blown cross-allergies that made her react to almost every fruit and vegetable, she found herself dependent on multiple antihistamines a day.But what if allergies aren't just allergies? What if they're actually signals that your immune system needs help?Join Michaela as she breaks down:• What allergies really are and why your immune system overreacts• The link between gut health, leaky gut, and food/environmental sensitivities• How heavy metals and nutrient deficiencies contribute to allergic conditions• The role of Omega-3s, beta-glucans, and local bee pollen in calming the immune system• How processed foods and AA buildup can trigger long-term inflammation• Her transformation from histamine overload to a life without symptoms—even in peak pollen seasonThis episode is packed with personal insight, scientific studies, and practical tools for anyone struggling with allergies, asthma, or chronic inflammation.

Description: Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Dr. Melanie Ruffner, an Attending Physician with the Division of Allergy and Immunology and the Center for Pediatric Eosinophilic Disorders at Children's Hospital of Philadelphia. Dr. Ruffner describes her work in clinic and the paper she co-authored about pediatric and adult eosinophilic esophagitis (EoE). She covers the questions they considered in the paper and the conclusions they reached. Disclaimer: The information provided in this podcast is designed to support, not replace the relationship that exists between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:49] Co-host Ryan Piansky introduces the episode, brought to you thanks to the support of Education Partners Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz.   [1:17] Holly introduces today's topic, pediatric and adult eosinophilic esophagitis (EoE), and introduces today's guest, Dr. Melanie Ruffner.   [1:23] Dr. Melanie Ruffner is an attending physician with the Division of Allergy and Immunology in the Center for Pediatric Eosinophilic Disorders at Children's Hospital of Philadelphia. Holly welcomes Dr. Ruffner to Real Talk.   [1:50] As an attending physician in the Center for Pediatric Eosinophilic Disorders at Children's Hospital of Philadelphia, Dr. Ruffner sees patients who have eosinophilic esophagitis and other eosinophilic disorders, including eosinophilic GI tract disorders.   [2:09] Dr. Ruffner also leads a research group that studies how the immune system causes inflammation in response to certain foods, leading to EoE.   [2:20] Inflammation in the esophagus is tied to other diseases like epithelial barrier dysfunction and fibrosis.   [2:28] Our bodies use many different proteins that allow cells to communicate with one another. One type of signaling protein that causes inflammation is called cytokines.   [2:41] Dr. Ruffner's group is interested in how these signaling proteins called cytokines interact with epithelial cells and how that impacts the oral function of the esophagus in patients with EoE.   [3:02] In training, Dr. Ruffner became interested in eosinophilic esophagitis and other non-IgE-mediated food allergies because we don't have a lot of clear treatments or clear mechanisms that cause them.   [3:21] Dr. Ruffner felt there was a lot of work to be done in that area. It was rewarding to be in clinical encounters with those patients. Often, patients had spent a long time trying to find out what was happening and to find a treatment plan that worked for them.   [4:31] Dr. Ruffner's group sees some patients who have eosinophilic gastroenteritis and patients who are referred for hypereosinophilia with impacts of inflammation in other organ systems.   [5:06] Dr. Ruffner co-authored a paper about pediatric and adult EoE published in the Journal of Allergy and Clinical Immunology. It explored if EoE in pediatric patients and adult patients is a spectrum or distinct diseases.   [5:29] EoE is a chronic allergic condition that affects the esophagus. The esophagus carries food from the mouth to the stomach. In people with EoE, the immune system overreacts to foods and causes inflammation in the esophagus.   [5:47] Eosinophils are a type of white blood cell. Eosinophils infiltrate the tissue in the esophagus of people with EoE. Doctors look for eosinophils in the tissue of the esophagus as a sign that inflammation in the esophagus is EoE.   [6:04] The symptoms of EoE can vary in children and adults. That was one of the things the doctors were interested in when they were thinking about this paper. There are no blood or allergy tests that make it easy to diagnose EoE, which requires an endoscopy.   [6:31] An endoscopy is performed by a gastroenterologist. The gastroenterologists look at the appearance of the esophagus and take biopsies.   [6:49] A pathologist counts the eosinophils in the tissue to determine if there are eosinophils present. If there are more than 15 eosinophils in the high-powered field of the microscope and symptoms and clinical conditions are present, EoE is diagnosed.   [7:25] One of the variables Dr. Ruffner considers is that symptoms can be different in children versus adults. In older adolescents and adults, the classic symptom is difficulty swallowing or dysphagia. That is often caused by fibrosis in the esophagus.   [7:54] In younger children this is often not how EoE presents. They may vomit or refuse food. They may experience more weight loss. Symptoms vary over the lifespan. Pediatric EoE symptoms of nausea and abdominal pain can also show up in adults.   [9:54] Atopy refers to allergic conditions. In the paper, a history of atopy means a history of allergic conditions, like atopic dermatitis, IgE-mediated food allergy, allergic rhinitis, or asthma.   [10:37] These disorders tend to cluster together, over time, because they share many common genetic risks. They cluster in families because some of the genetic risks are the same. Not every family member will have the same atopic or allergic conditions.   [11:07] In families, perhaps one person will have atopic dermatitis and allergic rhinitis while another will have atopic dermatitis, allergic rhinitis, asthma, and EoE. They may have inherited different genetics or had different environmental exposures.   [11:50] Ryan says that describes his family. They each have different atopic conditions. Ryan got them all! Dr. Ruffner says it describes her family, as well.   [12:26] Dr. Ruffner says it's understandable for families to stress about atopic conditions. Unfortunately, right now, there's no way to predict who will develop which atopic conditions. It's on the minds of the medical and research communities.   [13:10] IgE is an antibody that binds to food allergens and mediates anaphylaxis, usually within 30 minutes, with hives, vomiting, and difficulty breathing. Not everyone with a diagnosed food allergy will be given an epinephrine auto-injector.   [13:44] IgE-mediated food allergies are influenced by type 2 cytokines. Cytokines are immune system signaling proteins that have been labeled as groups. The group that is involved in allergy most heavily is under the label type 2.   [14:15] These type 2 cytokines are responsible for influencing B cells to make IgE. In the tissue in EoE, we find that there is a large amount of these type 2 cytokines present.   [14:37] This is quite relevant because dupilumab, the monoclonal antibody that has been approved to treat EoE, targets type 2 inflammation by blocking type 2 cytokines.   [16:04] Dr. Ruffner says one of the biggest challenges in the field of EoE is we don't have a way to stratify who should get which treatment for EoE. Patients have to choose between diet and pharmacologic therapy.   [16:48] We don't know enough about the inflammatory profiles to give any patient the specific guided information that one therapy would be better than another.   [17:11] Pediatric and adult patients are given the same treatment options. Some dosing, such as proton pump inhibitors and dupilumab, is weight-based so different doses are needed.   [17:36] Over time, people's needs change. From early school age to when people leave home, they may have very different needs. They may do well on diet therapy when their diet is controlled by parents, but, on their own, that may not be the best option for them.   [18:20] Therapy may change over time to support each patient's individual goals. It can be challenging because therapies are imperfect. Each therapy has a percentage probability of success. Not every therapy is guaranteed to work for every individual.   [19:01] There is some flexibility and possibility of switching between therapies to support people. Ryan shares one of his experiences in changing treatments.   [20:03] Some patients are stable on a therapy for a time but then see symptoms creep back up. Dr. Ruffner strongly suggests they talk to their care team for an endoscopy and biopsy to see if they need to switch therapy and if their diet has changed.   [21:31] In young children, Dr. Ruffner sees a much higher incidence of feeding refusal. The child may have a preferred food or a preferred texture like puree, long past when that would be appropriate for the age.   [22:41] It can be very difficult to move past this learned behavior even if remission is achieved through therapy. The child may need feeding therapy to help with that. [22:59] Feeding behaviors in older individuals may be much more subtle. Talk about them with your care team. Needing water to eat, cutting food very small, and fearing to eat around people are common eating behaviors to discuss in older patients.   [23:53] These eating behaviors affect people's well-being deeply because they affect how social they feel when they are around people. Ideally, you want to be around people and share in social times.   [24:16] Holly has used these eating behaviors herself and notices them in other people. When adults come to her for therapy, she asks how many times they refill their water when they eat, and if food ever gets stuck. They are surprised that those are symptoms.   [26:01] Dr. Ruffner says it's important to recognize the difference in symptoms in diagnosing EoE. The main risk factor of EoE is fibrosis, over time. The thought is that early in EoE there is an inflammatory phenotype, but later, there is a fibrotic phenotype.   [26:51] The phenotype refers to the presentation or characteristic of disease. What is the appearance at endoscopy? What do we see in the biopsied tissue? Is there fibrosis or not?   [27:15] This is the crux of the paper: Is this on a spectrum, that the inflammation is driving the fibrosis, or are these two different things altogether? There is some evidence to suggest that the inflammation contributes to this fibrosis over time.   [27:40] One thing that is missing is following a group of patients from the start and having that evidence. There is mechanistic evidence from studies to show that inflammation can contribute to fibrosis. That was one of the discussions in the paper.   [28:29] In endoscopies, something that can be seen with fibrosis or fibrostenotic features is more of an appearance of rings and narrowing of the esophagus. A proportion of patients with strictures or narrowing need to have them dilated.   [29:11] For patients who have dilation, it can help with symptoms significantly. When pathologists look at the tissue with fibrosis, they can see changes in the protein structure. There is more collagen and other changes in the tissue, causing fibrosis.   [30:03] Some patients use adaptive eating behaviors to adapt to significant changes in their esophagus and go for many years without being diagnosed until they present with an impaction when food becomes stuck in their esophagus.   [30:46] This makes EoE a challenging disorder for many because it can be very difficult to diagnose. The journey to a diagnosis is very individual. As a group, adults are much more likely to have fibrosis, leading to dysphagia, strictures, or impaction.   [31:25] Statistically, across all patients, you see fibrosis more in adults than in children.   [32:42] In the paper, Th1 cells are mentioned. Th1 is an immune system term referring to a cell that produces interferon-gamma. Studies show there may be differences in interferon signaling in different age groups but it needs to be studied further.   [33:57] Dr. Ruffner's team had looked at a small group and saw that interferon signaling seemed to be relatively similar between children and adults. Both CD4 and CD8 T cells (types of immune system cells) are potentially producing interferon in the esophagus.   [34:32] More study needs to be done around those immune system cells and their potential significance in EoE, if any.   [35:33] The paper suggests that EoE in children and adults is essentially a spectrum of the same disorder rather than distinct diseases.   [35:42] Aspects of immunology, responses to different treatments across children and adults, the similar responses to diet and different medications, and over time in the same individuals, indicate these are changes and complications over time.   [36:41] Dr. Ruffner suggests that medical researchers need to understand which patients are at the highest risk of complications and work to identify the best treatments to prevent those.   [37:14] Dr. Ruffner is thinking about the response to proton pump inhibitor therapy. One of the things she is looking at is whether or not proton pump inhibitors affect how eosinophils migrate into the tissue.   [37:33] They are finding that it seems that PPIs can decrease the degree of migration of eosinophils into the tissue. They are very interested in looking at that. Ryan says when Dr. Ruffner gets that paper published, she'll have to come back on the show!   [38:06] Ryan thanks Dr. Ruffner. For our listeners who would like to learn more about eosinophilic disorders, including EoE, please visit APFED.org and check out the links in the show notes.   [38:15] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at APFED.org/specialist.   [38:24] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at APFED.org/connections.   [38:33] Ryan thanks Dr. Ruffner for participating in the podcast episode. Holly also thanks APFED's Education Partners Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda for supporting this episode.   Mentioned in This Episode: Dr. Melanie Ruffner, MD, PhD, Attending Physician with the Division of Allergy and Immunology and the Center for Pediatric Eosinophilic Disorders at Children's Hospital of Philadelphia “Pediatric and adult EoE: A spectrum or distinct diseases?” by Stanislaw J. Gabryszewski, Melanie A. Ruffner, and Jonathan M. Spergel   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda.   Tweetables:   “EoE is a chronic allergic condition that affects the esophagus. The esophagus carries food from the mouth to the stomach. In people with EoE, the immune system overreacts to food allergens and causes inflammation in the esophagus.” — Dr. Melanie Ruffner   “In EoE, there are no blood or allergy tests that make it easy to diagnose EoE without an endoscopy.” — Dr. Melanie Ruffner   “Is EoE on a spectrum, that the inflammation is driving the fibrosis, or are these two different things altogether? There is some evidence to suggest that the inflammation contributes to fibrosis over time.” — Dr. Melanie Ruffner   “When pathologists look at the tissue with fibrosis, they can see the changes in the protein structure.” — Dr. Melanie Ruffner   “There are some folks who have adapted their eating behavior quite significantly and may have quite a number of chronic changes in their esophagus that they have adapted around, and they go for many years without being diagnosed.” — Dr. Melanie Ruffner

In this episode, we discuss the gut-immune axis and Small Intestinal Fungal Overgrowth (SIFO), with a mechanistic focus on immune activation and epithelial barrier disruption. We detail contributing factors to and symptoms of SIFO. We further discuss the anatomical positioning and immunological functions of mast cells within the lamina propria, highlighting mast cell activation syndrome, while detailing how SIFO and SIBO can serve as upstream triggers for mast cell activation.Topics:1. The Gut-Immune Axis and Mast Cells - The intestinal epithelium forms the innermost selective barrier, coated in a protective mucus layer.- Immediately beneath lies the lamina propria, rich in immune cells including mast cells. 2. Mast Cells in the Lamina Propria - Mast cells are positioned near nerves, capillaries, lymphatics, and epithelial cells within the lamina propria.- Their anatomical location enables rapid immune surveillance and inflammatory response.- Mast cell granules store histamine and more. 3. Mast Cell Mediators - Histamine: Biogenic amine, inflammatory signaling.- Tryptase: A serine protease.- Cytokines and lipid mediators also released upon activation. 4. Mast Cell Activation Syndrome (MCAS) - Systemic: skin, respiratory tract, cardiovascular system, nervous system, and more.- The gastrointestinal tract.- Common triggers for mast cell activation. 5. Transition to Small Intestinal Fungal Overgrowth (SIFO) - Overgrowth of fungal organisms, often candida species, within the small intestine.- Contributing factors including hypochlorhydria, slowed motility, immune suppression, disrupted bacterial populations.- Overlap: SIFO, SIBO  6. Hypochlorhydria and the Stomach's Defense Role - Parietal cells secrete hydrochloric acid (HCl) and intrinsic factor.- HCl denatures proteins and sterilizes ingested pathogens.- Chief cells secrete pepsinogen, which becomes pepsin in acidic conditions to digest proteins.- Consequences of Reduced Gastric Acidity  7. The Role of Intestinal Motility - Enteric nervous system (ENS), myenteric and submucosal plexuses.- Coordinated contractions preventing stasis and microbial overgrowth. 8. Common Symptoms of SIFO and clinical overlap with SIBO 9. Candida and Fungal Pathophysiology in the Gut - Yeast form, regulated by microbial competition and immune defenses.- Hyphal transformation.- Degrade the mucus layer, disrupt epithelial integrity, trigger inflammation. 10. Secretory IgA and Mucosal Defense - Chronic stress, immune dysfunction, dysbiosis can lower sIgA levels and weaken mucosal immunity. 11. SIFO, SIBO, and Mast Cell Activation  12. Conclusion  - Root cause approach, multi-factorial Thanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

Cancer cachexia isn't just weight loss—it's a hijacking of motivation

Send us a textIf you like learning about the mysteries of the immune system - you're going to like this episode! Dr Yas makes learning about the immune system fun - even going so far as to create poke-immune cards on instagram. If you are a pokemon fan & science lover - you'll love it. Check out an example below.Dr Yasmin Mohseni, PhD is an immunologist with 6+ years of experience in the cell and gene therapy biotech space, specialising in immunotherapy for cancer and immunoregulation. Dr Mohseni earned her PhD in Immunotherapy from King's College London, where she focused on using engineered regulatory T cells (Tregs) to promote immune tolerance in solid organ transplantation with applications to autoimmunity. She began her industry journey at Quell Therapeutics, advancing Treg-based therapies, and now works at A2 Biotherapeutics in the cancer immunotherapy space, developing therapies for solid tumours. She currently serves as the scientific lead within Quality, bridging analytical strategy, process and product knowledge improvements within CMC.Dr. Yasmin Mohseni is an immunologist with an interest in immunology and cancer biotech. She discusses the emotional complexities of being an IBD patient while also being a scientist, the intricacies of the immune system, and her current role in developing immunotherapies for cancer treatment. The conversation highlights the importance of understanding the immune system's balance and the potential of immunotherapy in revolutionizing the future healthcare. In this conversation, Dr. Yasmin Mohseni delves into the complexities of the immune system, particularly in relation to Inflammatory Bowel Disease (IBD), immune memory and the effects of stress. The discussion highlights the mechanisms of immune responses, the role of cytokines, and how various factors, including hormones and stress, can influence immune health and disease progression.Takeaways-Dr. Yasmin Mohseni shares her experience of becoming an immunologist.Immunology is about communication between cells.T cells play a crucial role in fighting cancer.Immunotherapy is changing the landscape of cancer treatment.The immune system not only protects the body from invaders but also aids in healing and repair.Inflammation is a natural response to infection.Understanding the immune system can empower patients. IBD involves complex immune responses and genetic predispositions.Cytokines serve as crucial communicators in the immune system.Antibody presence does not always indicate immune memory.Chronic stress can lead to dysregulated immune responses.Pregnancy can alter immune responses, affecting autoimmune diseases..Understanding immune memory is essential for vaccine responses.The relationship between hormones and immunity is nuanced and complex.Follow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here.

Guest: Kathleen M. Buchheit, MD Guest: Joseph K. Han, MD Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with a low quality of life and increased healthcare utilization,1,2 and patients often continue to have severe symptoms despite therapy.​3 Understanding the role of underlying inflammatory pathways and epithelial dysfunction may help inform clinical decision making for these patients.​3,4 In this program, Dr Kathleen Buchheit and Dr Joseph Han share their insights on the pathophysiology of CRSwNP and how unaddressed underlying inflammation may contribute to a variety of challenges for patients. Dr Buchheit is an Assistant Professor of Medicine at Harvard Medical School, specializing in Allergy and Immunology. Dr Han is a Professor of Otolaryngology, the Chief for the Division of Rhinology and Endoscopic Sinus and Skull Base Surgery, and the Chief of the Division of Allergy at Eastern Virginia Medical School in Norfolk, Virginia. References: Mullol J, et al. J Allergy Clin Immunol Pract. 2022;10:1434-1453.e9 Bhattacharyya N, et al. Laryngoscope. 2019;129:1969-1975. van der Veen J, et al. Allergy. 2017;72:282-290. Laidlaw TM, et al. J Allergy Clin Immunol Pract. 2021;9:1133-1141. ©2024 Amgen and AstraZeneca. All rights reserved.US-96000 Last Updated 12/24

In this brief video, learn more about growing evidence supporting the key role of airway epithelium dysfunction in driving inflammation in CRSwNP. ©2025 Amgen and AstraZeneca. All rights reserved.US-94728 Last Updated 1/25

In this episode, we detail the gut's intricate immune defenses, emphasizing the role of mast cells in inflammation and immune signaling. We extend this conversation to Mast Cell Activation Syndrome briefly going through potential triggers, tests, and symptoms. Finally, we examine the bidirectional relationship between MCAS and Small Intestinal Bacterial Overgrowth (SIBO), illustrating how mast cell mediators and microbial byproducts can drive a cycle of chronic inflammation and increased intestinal permeability. Topics: 1. Introduction to the Gut-Immune Axis - Focus: mast cells, small intestinal bacterial overgrowth (SIBO), and mast cell activation syndrome (MCAS). 2. Anatomy of the Gastrointestinal Lining - Intestinal lumen, microbiome, mucus layer, epithelial monolayer, tight junctions, and lamina propria. - Role of the smooth muscle and deeper layers supporting the mucosal structures. 3. Gut-Associated Lymphoid Tissue (GALT) - Peyer's patches, mesenteric lymph nodes (MLNs), isolated lymphoid follicles (ILFs), intraepithelial lymphocytes (IELs), and dispersed immune cells in the lamina propria. - Function of GALT. 4. Peyer's Patches and Antigen Exposure - Location and function of Peyer's patches. - Role in antigen sampling and processing. 5. Immune Cells in the Lamina Propria - Overview of interspersed immune cell populations. 6. Focus on Mast Cells - Key roles of mast cells in the gut's innate immune system. - Locations with a focus on the lamina propria. 7. Mast Cell Mediators - Histamine - Tryptase: tissue remodeling, impact on intestinal permeability. - Cytokines, prostaglandins, and leukotrienes. 8. Mast Cell Activation Syndrome (MCAS) - Overactivation of mast cells and excessive release of inflammatory mediators. - Effects on gut barrier function. - Pathological behavior due to altered activation thresholds, receptor expression, and tissue environment changes (not resulting from an increased number of mast cells). 9. MCAS Symptoms and Systemic Effects - Abdominal pain, cramping, bloating, diarrhea, and nausea. - Systemic symptoms: skin reactions, respiratory and cardiovascular effects, neurological impacts. 10. Triggers and Conditions Associated with MCAS - Environmental toxins, infections, stress, chemical exposures. - Hypermobile Ehlers-Danlos syndrome (hEDS), dysautonomia (e.g., POTS). 11. MCAS Testing - Testing limitations: variability in mediator release and transient nature of mast cell degranulation. - Serum tryptase, urinary N-methylhistamine, plasma heparin levels, specific cytokines like IL-6, and more. 12. Small Intestinal Bacterial Overgrowth (SIBO) - Overview of SIBO. - Slow motility, low stomach acid. 13. Interaction Between SIBO and Mast Cells - SIBO-induced mast cell activation. - Cycle of inflammation, increased intestinal permeability, and gut dysfunction. 14. Conclusion - Recap of the intestinal anatomy and immune cell focus. - MCAS triggers, symptoms, and testing. - Connections between SIBO and MCAS, emphasizing an inflammatory cycle. Thank you to our episode sponsor: 1. Check out ⁠⁠⁠Ulyana Organics'⁠⁠⁠ ⁠⁠⁠Tallow Wild Yam Cream⁠⁠⁠ and ⁠⁠⁠Healing Facial Oil⁠⁠⁠, and use code ⁠⁠⁠CHLOE10⁠⁠⁠ 10% off your order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

In this episode, Lorrie chats with Dr. Raymond Perrin about his groundbreaking insights into ME Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome, Fibromyalgia and Long COVID, revealing how his revolutionary Perrin Technique helps drain toxins from the brain's glymphatic system to support recovery. Discover the hidden connections between the brain, lymphatic system, and chronic illness and learn techniques you can do at home. About Dr. Perrin:Dr. Perrin's research since 1989 into ME/Chronic Fatigue Syndrome and now Long COVID has expanded our knowledge of diagnosis and treatment of complex neurological disease.

My guest today is Dr. Kristen Lyall, ScD. Dr. Lyall received a Doctor of Science in Epidemiology from Harvard School of Public Health. During her postdoctoral training, she received training in Nutrient Science at Harvard and Pediatric Epidemiology at UC-Davis MIND Institute's Autism Research Training Program. Currently, Dr. Lyall is an Associate Professor at Drexel University's A.J. Drexel Autism Institute – Modifiable Risk Factors Program.The overarching goal of the Modifiable Risk Factors program is to identify factors that can be changed to prevent or mitigate the adverse effects associated with Autism, thereby potentially improving outcomes for individuals and informing public health policy and practice. Dr. Lyall's expertise provides actionable tools for listeners to understand the environmental risks of Autism. By the end of the episode, we hope you gain insight into the identified modifiable risk factors for Autism.Dr. Kristen Lyall: https://drexel.edu/autisminstitute/about/our-team/all-staff/Kristen-Lyall/Dr. Lyall publications link: https://pubmed.ncbi.nlm.nih.gov/?term=Kristen%20Lyall&sort=pubdateECHO: https://echochildren.orgFish not Supplements: https://echochildren.org/research-summaries/fish-but-not-supplements-consumed-in-pregnancy-associated-with-lower-rates-of-autism-diagnosis-and-related-traits-echo-cohort-study-finds/Other Resources:Biological Energy: Quantum Mechanisms, Water, DHA, and NF-kB (Autism is a loss of energy- electrons, photons, protons)https://youtu.be/2-IA_gunXbw0:00 Dr. Kristen Lyall2:30 Her Journey into Epidemiology & Autism7:50 The Role of Epidemiology & Autism12:15 Modifiable Risk Factors17:32 Dietary Influences on Autism Risk; Eat more FISH (DHA!)22:53 Assessing Exposure & Risk Factors32:35 Immune & Hormonal Factors in Autism; Cytokines & Inflammation39:17 The Impact of Acute Events during Pregnancy44:45 Air Pollution & its Effects in Neurodevelopment; Oxidative Stress48:14 Current & Future Research; ECHO & EARLI56:34 Reviews/Ratings, Contact InfoX: https://x.com/rps47586YouTube: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAHopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com

Send us a textAs a result of the rapid adoption CAR-T therapy for certain lymphoid malignancies and multiple myeloma, of these treatments, CRS and ICANS will become more common in IM wards in the coming years. Take a listen to learn about how to treat this emerging condition. This episode was written by Dr. Veronica Ramirez (Internal Medicine Resident) and reviewed by Dr. Kelly Davison (Hematology) and Dr. Blair Schwartz (General Internist and Intensivist). Infographic by Neeloufar Grami (medical student).Support the show

Recent studies from Harvard Medical School have suggested that inflammation may play a role in the development of autism. A study published in the Journal of Neuroinflammation found that children with autism had higher levels of inflammatory markers in their blood than typically developing children. Inflammation is a crucial process for our health, but when it becomes chronic, it can lead to a host of health problems. Cytokines signal the immune system to protect the body from threats like bacteria, allergens, toxins, and other harmful microbes and substances. In this case, they are pro-inflammatory, so they create inflammation as a defense mechanism for the body.  Another study published in the Journal of Autism and Developmental Disorders found that children with autism had higher levels of inflammatory cytokines in their brains than typically developing children.  Studies increasingly indicate a strong inflammatory state associated with ASD [11]. This inflammatory condition is often linked to immune system dysfunction [12]. Enhanced inflammatory activity in ASD children has been demonstrated through pro-inflammatory biomarkers analysis. What is inflammation and how is it related to autism? Inflammation is a natural response by the immune system to protect the body from any harmful stimuli. However, when inflammation becomes chronic, it can lead to tissue damage and a variety of health problems, including autoimmune disorders, heart disease, and even neurological disorders like autism. Recent research has suggested that inflammation may contribute to the development of autism by disrupting healthy brain development during critical periods of growth in utero or early childhood. Inflammation can also exacerbate symptoms associated with autism, such as irritability and social withdrawal. Children with autism often have chronic inflammation. This is not only a problem in the digestive system but also in the brain. Inflammation impairs brain cells and it can also kill them.  If the brain cells are weakened, they are even less capable of fending off toxins or excreting them once they have entered the cell... Click Here or Click the link below for more details! https://naturallyrecoveringautism.com/209

In this episode of Accelerated Health with Sara Banta, I explore the fascinating world of cytokines, the molecules that serve as your body's communication network. Discover how cytokines regulate inflammation, immunity, and overall health while playing a critical role in maintaining balance within your body. I break down what cytokines are, the difference between pro-inflammatory and anti-inflammatory cytokines, and how factors like diet, stress, and sleep influence their activity. Plus, learn practical tips to support a balanced immune response and optimize your overall well-being. Supplements Featured In This Episode:• Accelerated Scalar Copper® https://www.acceleratedhealthproducts.com/products/accelerated-scalar-copper • Accelerated Liver Care™ https://www.acceleratedhealthproducts.com/products/accelerated-liver-care • Acceleradine® Iodine https://www.acceleratedhealthproducts.com/products/acceleradine-iodine-supplement • Accelerated C60™ https://www.acceleratedhealthproducts.com/products/accelerated-c60 Not sure what food to eat and avoid? This guide is for you.⬇️

In this episode of Derms and Conditions, host James Q. Del Rosso, DO, welcomes E. James Song, MD, Chief Medical Officer at Frontier Dermatology, to explore the nuances of systemic therapy selection for atopic dermatitis (AD) and offer practical guidance on tailoring treatment plans to optimize outcomes for these patients. They begin by discussing the importance of considering patient-specific factors, such as contraindications, access, and age, when selecting among the 3 currently available biologics for AD: dupilumab, tralokinumab, and lebrikizumab. While these therapies share many similarities, nuanced differences—such as dupilumab's approval for younger patients and asthma comorbidity, or lebrikizumab's sustained efficacy after discontinuation—can guide treatment decisions. They also discuss adverse events, including conjunctivitis and dupilumab-associated facial erythema, highlighting strategies for managing these issues. Dr Song notes that switching within the IL-13 pathway can often resolve conjunctivitis and speculates on the possible mechanisms behind facial redness. They then explore one critical insight: the potential for patients to fail one biologic and still respond to another within the same class. While complete nonresponders may benefit from switching to a different class, such as JAK inhibitors, partial responders often do well with another IL-13 inhibitor. Tune in to the full episode to explore more insights on optimizing AD management, including how to navigate biologic options, manage adverse events, and approach challenging cases while embracing new therapies and tailoring care to each patient's unique needs.

In this episode, we examine the bidirectional relationship between intestinal health and immune aging, emphasizing how gut barrier dysfunction and microbial imbalances accelerate systemic inflammation and diminished immune function. Furthermore, we explore the effects of aging on intestinal barrier function, focusing on the decline in tight junction integrity, reduced mucus production, and impaired epithelial renewal, all of which contribute to increased gut permeability and chronic inflammation. Thus, restoring microbial diversity, supporting mucosal defenses, and addressing gut permeability are essential strategies to break this cycle and promote healthy aging. Topics: 1. Introduction: Immune Aging - Immune aging: a decline in immune function, increasing vulnerability to infections and chronic diseases. - The intestinal microbiome influences and is shaped by immune aging. - Microbial metabolites, epithelial integrity, and immune signaling are critical. 2. Anatomical Context of the Gut and Immune Cells - Gut layers: lumen, mucus, epithelium, lamina propria, and more. - The mucus layer protects the epithelium; function can become impaired with age. - Tight junctions prevent pathogen entry, while the lamina propria houses immune cells. 3. Mucus Layer and Goblet Cells: Role and Aging Effects - Goblet cells secrete mucins that form the protective mucus layer. - Aging can reduce mucin production, weakening the mucus barrier. - A thin mucus layer increases epithelial exposure and inflammation risk. 4. Microbial Interactions with the Mucus Layer - Commensal bacteria support mucus turnover by controlled mucin degradation. - Dysbiosis can disrupt this process, thinning the mucus layer. - Reduced mucus protection increases susceptibility to pathogens. 5. Effects of Immune Aging on the Intestinal Barrier - Aging effects on T cells, B cells, and inflammatory cytokine secretion. - Cytokines disrupt tight junctions and increase permeability. - Microbial products like LPS (endotoxin) cross the barrier, fueling chronic inflammation. 6. Dysbiosis and Its Role in Immune Aging - Dysbiosis reduces SCFA production and Treg activity. - Dysbiosis promotes chronic inflammation and accelerates immune aging. 7. Microbial Translocation and Systemic Effects - A weakened barrier allows microbial products to reach immune cells. - LPS triggers inflammatory signaling, amplifying systemic inflammation. - Chronic inflammation perpetuates gut dysfunction and immune aging. 8. Conclusion - Immune aging and intestinal health are interconnected in a feedback loop. - Aging weakens the gut barrier, while dysbiosis amplifies inflammation. - Restoring microbial balance and gut integrity is vital for healthy aging. Thanks for tuning in! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/CC information, and to apply for credit, please visit us at PeerView.com/AYT865. CME/MOC/CC credit will be available until November 9, 2025.Uncovering the Role of Epithelial Cytokines in CRSwNP: Examining the Clinical Implications of New Approaches with Targeted Biologic Therapy In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AstraZeneca LP.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/CC information, and to apply for credit, please visit us at PeerView.com/AYT865. CME/MOC/CC credit will be available until November 9, 2025.Uncovering the Role of Epithelial Cytokines in CRSwNP: Examining the Clinical Implications of New Approaches with Targeted Biologic Therapy In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AstraZeneca LP.Disclosure information is available at the beginning of the video presentation.

Today on the Holistic Dentistry Show, Dr. Sanda continues her exploration of jaw bone cavitations and discusses how they form and why they are so difficult to diagnose. Jawbone cavitations can significantly impact overall health, especially for those with chronic pain. Dr. Sanda breaks down the science of what exactly a jawbone cavitation is and how it can lead to osteonecrosis and inflammation. Studies show that jawbone cavitations are linked to elevated cytokine levels, which is why they are linked to systemic health issues. Dr. Sanda identifies lifestyle choices and related health issues that may increase the risk of developing a jaw cavitation, including root canals. Jaw cavitations can be difficult to diagnose, and Dr. Sanda emphasizes receiving proper diagnosis and treatment.  Call our office at (310) 275-4180 to find out more about cavitations! Want to see more of The Holistic Dentistry Show? Watch our weekly episodes on YouTube!  Do you have a mouth- or body-related question for Dr. Sanda? Send her a message on Instagram! Remember, you're not healthy until your mouth is healthy. So take care of it in the most natural way.  Key Takeaways: (1:13) How jaw bone cavitations form (03:36) Cytokines in cavitations (07:02) Fatty Degenerative Osteonecrosis (FDOJ) (09:56) Root canal treatments and cavitations (12:49) How cavitations impact overall health Resources Mentioned: IAOMT Position Paper on Human Jawbone Cavitations Connect With Us:  BeverlyHillsDentalHealth.com |  Instagram  DrSandaMoldovan.com | Instagram  Orasana.com | Instagram

Dr. Chad Cook is interviewed by Dr. Tony Varela discussing his recent publication, “A Narrative Overview of Manual Therapy and Exercise Effects on Inflammatory Cytokines.”

Dr. Chad Cook (E-mail, X, LinkedIn) is interviewed by Dr. Tony Varela discussing his recent publication, “A Narrative Overview of Manual Therapy and Exercise Effects on Inflammatory Cytokines.” The discussion offers empirical and anecdotal analyses of treatment mechanisms for physical therapists.Here is the article referenced in the interview, “Priorities in updating Training Paradigms in Orthopaedic Manual Therapy: an International Delphi Study”Find out more about the Foundation for Orthopaedic Manual Physical Therapy (FOMPT) and the American Academy of Orthopaedic Manual Physical Therapists (AAOMPT) at the following links:Foundation website: www.aaompt.org/foundationAcademy website: www.aaompt.orgTwitter: @AAOMPTFacebook: https://www.facebook.com/aaompt/Instagram: https://www.instagram.com/officialaaompt/?hl=enPodcast e-mail: aaomptpodcast@gmail.comPodcast website: https://aaomptpodcast.simplecast.fm

In this week's episode, we continue our series on Adverse Childhood Experiences by delving deeper into the lasting effect of ACEs on the brain and body. We explore the intricate impact of ACEs on the HPA axis, inflammation, and neurobiology, shedding light on their role in various psychiatric disorders. We highlight how these changes may indicate a shared phenotype resulting from early adversity but that they likely do not explain the entire effect ACEs have on an individual.  

In this episode, Brendan Vermeire talks about mental health, from depression, anxiety, and neuroinflammation to dementia and Alzheimer's. They dive into: 1. Debunking the classic psychiatric narrative 2. Inflammation and mental health symptoms 3. The role of neuroplasticity in mental health 4. How does the microbiome affect mental health? 5. The Mental M.A.P. Brendan is a mental and metabolic health researcher, functional medicine educator, board-certified holistic practitioner, personal trainer, writer, speaker, and host of The Holistic Savage podcast. He is also the owner and founder of the Metabolic Solutions Institute for Functional Health and Fitness Practitioners and the Metabolic Solutions Research & Education Foundation, a not-for-profit foundation dedicated to "changing the way the world views mental health" through advancing the science of mental health dysfunction.

How closely are your emotions linked to your physical health? Today on the Vibrant Wellness Podcast, we welcome Nicole Reilkoff, a certified naturopath and reflexologist. She shares her journey from childhood trauma and addiction to holistic wellness. Join Dr. Emmy Brown and Melissa Gentile as they explore the world of hormones, neurotransmitters, and cytokines, showing how these biochemical forces shape our emotional well-being. We'll discuss common myths about diet and lifestyle's role in mental health and stress the importance of addressing emotional states in healing.Ever wondered about the gap between the physical body and the soul? We investigate this divide through the lenses of Western science and Chinese energetic medicine. Building on Candace Pert's idea of the body as the subconscious mind, we point out the deep physiological roots of emotions and the need to integrate this understanding into holistic practices. Our conversation reveals how cultivating body trust and situational awareness can foster healthier connections with oneself and others, highlighting the power of vulnerability and open communication.Lastly, we illuminate the profound mind-gut connection and how societal constructs shape our emotional experiences. From mindful eating to the challenging but crucial process of dissociation for trauma survivors, we cover practical strategies to enhance both emotional and physical health. We wrap up with advice on nutrition and sleep, emphasizing the transformative power of positive self-talk and holistic approaches to healing. Tune in for an insightful discussion that will elevate your understanding of holistic health and emotional well-being.Chapters:(00:00) Emotional Health and Holistic Healing(15:12) Understanding the Mind-Body Connection(23:17) Understanding Gut Health for Emotional Well-Being(33:21) Mind-Body Connection Through Nutrition and Sleep(42:47) Healing the Gut Through MindsetLinks:www.mvnaturopathie.comJoin Over 18,000 Leading Medical Professionals and Become a Vibrant Wellness Provider Today! https://portal.vibrant-wellness.com/#/sign-up

For more information regarding this CME/CE activity and to complete the CME/CE requirements and claim credit for this activity, visit:https://www.mycme.com/courses/dd5-your-questions-on-cytokines-in-asthma-9477SummaryIn this activity, moderator Corinne Young works with asthma expert Amanda Michaud to answer the common and remaining questions regarding inflammation in asthma, the role of TSLP and other alarmins, and the modulation of upstream and downstream cytokines with available and emerging biologic agents for asthma. Five questions in fifteen minutes – can they do it?!Learning ObjectivesUpon completion of this activity, learners should be able to: Discuss the role of epithelial cytokines in the inflammatory response of asthma and other airway diseasesSelect appropriate agents to target the ongoing inflammatory cascade in patients with severe asthmaThis activity is accredited for CME/CE CreditThe National Association for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.The National Association for Continuing Education designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.National Association for Continuing Education is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 121222. This activity is approved for 0.25 contact hour (which includes 0 hours of pharmacology).For additional information about the accreditation of this program, please contact NACE at info@naceonline.com.Summary of Individual DisclosuresPlease review faculty and planner disclosures here.Disclosure of Commercial SupportThis educational activity is supported by an independent educational grant from AstraZeneca Pharmaceuticals.Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

This journal club episode comes to you from the 2024 Tri-State Dairy Nutrition Conference. The paper is “Major Accomplishments in Calf Nutrition and Growth” from the conference proceedings.Accelerated milk feeding of calves results in about a thousand-pound first lactation production increase. The mechanism is unclear: it could be isolated to the mammary gland or related to the functional ability of the digestive tract and liver to support lactation. Economic analyses have shown an advantage of $205 per calf. (6:04)Regarding amino acid requirements of dairy calves, whey-based milk replacers require additional methionine; lysine is also common. Threonine can be limiting in soy-based milk replacers. Establishing amino acid requirements was beyond the scope of what the NASEM committee could do, and more data is probably needed for calves. However, CNCPS has amino acid requirements defined, so it's possible to get in the ballpark for amino acids. (12:00)What about feeding hay to young calves? The latest research has shown calves only over-consume alfalfa out of all the common forages. A study in Spain showed when offered alfalfa, calves consumed 14% of their total dry matter from alfalfa, decreasing the amount of starter they consumed. When offered grass hay or straw, calves only consumed 4-5% forage and they actually boosted starter intake and overall feed efficiency. Dr. Drackley recommends starting grass hay, wheat straw, or similar forages at 2-3 weeks of age. It should be just a sprinkling top dressed on their starter, or about 5% of the total if you're feeding a mixed diet. (15:08)Dr. Drackley covers five major accomplishments in this paper. (18:06)Knowledge of colostrum, highlighting the establishment of different categories for passive transfer (excellent, good, fair, and poor) rather than just a yes or no. The four categories relate very well to the mortality and morbidity associated with young calves. Feeding more milk to young calves, highlighting a 2001 paper from Dr. Mike Van Amburgh's lab that was the eye opener for the industry. The publication of the NRC in 2001, which had a separate chapter for calves, was perhaps the first time people started to think seriously about calves.Major growth in behavior research, particularly related to feeding behavior, shows calves fed conventional, limited amounts of milk are hungry as demonstrated by vocalization and increased restlessness.Publication of NASEM 2021.From a welfare research perspective, Dr. Drackley thinks cow-calf separation and group vs hutch housing will continue to be issues of concern for consumers. In Europe, there's demonstration research keeping calves with cows during the milk-feeding period. (20:44)What about the post-weaning slump? The big issue is weaning too early before starter intake has increased adequately. Weaning at eight weeks instead of six weeks results in an improvement in total nutrient intake. A gradual step down in the amount of milk provided will also stimulate starter intake. Starter quality and composition is critical, and water availability can be an issue for many farms. (23:29) Concerning colostrum, a big advancement has been a better understanding of what colostrum does in addition to establishing passive immunity. The nutrition aspects of high protein, vitamins, minerals, and growth-promoting ingredients like hormones, growth factors, and cytokines all play a major role in calf health and development. Measuring colostrum quality is better and easier with the use of refractometers. Recent emphasis on how easily colostrum can be contaminated and how that negatively affects the calf has also been crucial. As much as we know about milk synthesis, we know very little about colostrum synthesis. Adequate metabolizable protein is important for quality and quantity, and immune-related vitamins and minerals are important. Beyond that, we do not have a good understanding of what regulates colostrum, particularly volume. (25:50)What's next in calf nutrition? Establishing a good amino acid model and trying to minimize both costs and nitrogen excretion, colostrum quality and quantity from the cow side, continued research into workable systems for accelerated milk feeding with a smooth weaning transition, and post-weaning feeding programs are areas where Dr. Drackley predicts fruitful research opportunities. (31:36)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

CardioNerds (Drs. Richard Ferraro, Gurleen Kaur, and Rupan Bose) discuss the growing epidemic of obesity and dive into the role of its procedural management with Dr. Steve Nissen, Chief Academic Officer at the Cleveland Clinic HVTI and past president of the American College of Cardiology. This is an exciting topic that reflects a major inflection point in cardiovascular care. In this episode, we discuss the importance of addressing obesity in cardiovascular care, as it is a major driver of cardiovascular disease and the progression of associated cardiovascular comorbidities. We look at the role of bariatric surgery and its ability to produce sustained weight loss. Finally, we look into the emerging role of new medical therapies such as GLP1 and GIP agonist medications. Notes were drafted by Dr. Rupan Bose and episode audio was edited by CardioNerds Intern Dr. Atefeh Ghorbanzadeh. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - Procedural Management of Obesity with Dr. Steve Nissen Obesity is associated with adverse cardiovascular outcomes. Returning to a healthy weight can largely prevent the downstream consequences of obesity. Regarding lifestyle modifications, diet alone is insufficient in sustaining prolonged weight loss. It is associated with short-term weight loss, but it is generally necessary to supplement with exercise and activity to ensure sustained weight loss. Bariatric surgery should be considered for patients with BMI ≥40 kg/m2 or BMI ≥35 kg/m2 with obesity-related comorbid conditions who are motivated to lose weight and who have not responded to behavioral treatment with or without pharmacotherapy. New emerging medications, including GLP1 receptor agonists, GIP receptor agonists, and glucagon receptor agonists, are beginning to approach weight loss levels that were previously only seen with bariatric surgery. Further research in this dynamic area is ongoing. Show notes - Procedural Management of Obesity with Dr. Steve Nissen Notes drafted by Dr. Rupan Bose. What is the role of obesity in the burden of cardiovascular disease, and why is it so important for CardioNerds to address it? According to the AHA, approximately 2.8 to 3.5 billion people worldwide are either overweight or obese. It is estimated that by 2030, 30% of people in the US will have a BMI greater than 30. Adipose tissue is associated with cytokine release. Cytokines, in turn, can activate and increase levels of IL-1 beta, IL-6, and CRP, leading to an increased inflammatory state. This pro-inflammatory state then accelerates the rate of cardiovascular disease. Obesity is also associated with significant joint and orthopedic diseases, which further impact patients' quality of life and morbidity. Additionally, obesity is associated with NASH cirrhosis. These adverse liver outcomes hold additional significant systemic implications and morbidity. How do you determine one's goal weight and goal BMI? Is BMI a good standard for measuring obesity? BMI is a variable of both weight and height. However, it cannot differentiate those whose weight is from adipose tissue versus from muscle mass. Therefore, BMI measurements can sometimes be misleading. Waist circumference may be a better measurement standard for obesity and risk assessment. The “apple shape” body type, with more abdominal fat, is associated with higher inflammation and cardiovascular risk than the “pear-shaped” body type, which is where there is more fat deposition in the buttocks a...

On this week's episode, I am going to be talking about why I think Ozempic does NOT cause muscle loss. I'm also going to be talking with you about how you are shooting yourself in the foot if you are not strength training and building muscle when you're trying to get your metabolic health in order. If you have pre-diabetes or diabetes, listen up, because you can go as low carb as you want and you can take all the Ozempic in the world, but you are never going to get ahead if you're not actively building muscle. On This Episode We Cover: 03:52 - Ozempic training series 04:21 - The dangers of losing weight on a caloric restriction diet 09:20 - Cytokines  10:16 - Your muscles is your metabolic sync  11:25 - Your brain reprograms itself to make it harder to keep the weight off  12:04 - Ozempic and skinny fat 14:39 - Insulin resistance  15:33 - Using glucose for fuel 18:08 - Building muscle builds more insulin receptors 19:49 - Keeping insulin in check 21:34 - Strength training improves insulin sensitivity  22:35 - You can't have balanced hormones without optimized metabolic health and muscle mass 25:14 - Diabetes prevention and strength training 25:57 - Pilates and strength training  27:30 - GLP1 agonists protect and regenerate muscle tissue  28:40 - Incorrectly using ozempic 29:50 - Your muscle is your health insurance  30:57 - Glutes are the center of your vitality  32:36 - Benefits of peptides while used in correct doses  34:16 - GLP1s do not cause muscle loss 36:59 - Good protein synthesis mode  38:30 - Paleo valley protein powder 39:55 - Make strength training a priority Show Links: Ozempic Uncovered Dr. Tyna's Strength Corner Sponsored By: ALITURA NATURALS SKIN CARE Use Code DRTYNA for 20% off www.alitura.com Paleovalley For 15% off go to http://paleovalley.com/drtyna BIOptimizers  Go to bioptimizers.com/drtyna and use code DRTYNA to save 10% and get a free gift with purchase Head to www.Drtyna.com for the following offers: GET MY “OZEMPIC DONE RIGHT” FREE Mini-Course: https://www.drtyna.com/ozempicdoneright Grab my FREE GUIDE to Assess Your Metabolic Health. Check out my Metabolic Revamp Toolkit for a deeper dive. Grab My Winter Crud Cheat Sheet Now! Click Here! Further Listening: EP 106: Ozempic Done Right Part 1 | Solo Episode  EP 107: Ozempic Done Right Part 2 | Solo Episode  EP. 109: Ozempic Done Right Part 3 | Solo Episode EP. 116: Berberine: Not Natures Ozempic | Quick & Dirty Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Lou Hawthorne is the founder and CEO of NaNotics, LLC, and the inventor of the company's core technology. Lou is an entrepreneur with 27 years of experience in founding and leading companies developing new technologies in biotech/life science and information technology, including reproductive cloning, human IVF, oncology, and artificial intelligence. In 2002, Lou founded the cloning companies Genetic Savings & Clone and BioArts International, and co-founded Viagen, Inc. acquired by Intrexon (XON) in 2014. In 2014, Lou conceived "NaNots" – which are subtractive immune modulators – and founded NaNotics LLC, which is currently developing NaNots for treating cancer, sepsis, autoimmune disease and aging, in collaboration with Mayo Clinic and other groups. NaNots have demonstrated near total tumor suppression in humanized mouse models of cancer, significantly outperforming checkpoint inhibitors. NaNots are the subject of 30 granted patents to date. Lou is an experienced company leader with an extensive track record in funding, recruiting and managing senior level multi-disciplinary teams for effective development of new technologies. He has collaborated closely with NaNotics company co-founder, John Dodgson, PhD, a physical chemist and IP expert, for two decades. Lou is also an expert at brand development and strategic media, having designed global media campaigns that reached millions of people and generated profile valued at hundreds of millions of dollars. He has been interviewed by most major newspapers, magazines, and television programs, including appearances on The Oprah Winfrey Show and Good Morning America. Lou holds a B.A. in English Literature from Princeton University, where he was a University Scholar and recipient of the Ward Mathis prize. PODCAST INFO:The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKSSpotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRHRSS: https://www.learningwithlowell.com/feed/podcast/Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com Lou hawthorne linkshttps://www.nanotics.com/https://www.linkedin.com/in/louis-hawthorne-b654b12b/https://twitter.com/thelouhawthorne?lang=enhttps://www.lifespan.io/news/lou-hawthorne-nanotics-on-cleaning-blood-with-nanoparticles/ Timestamps00:00 Introducing Lou Hawthorne02:20 PTSD / depression / cytokine disorders07:50 Cytokines / mental health09:00 Appling NaNots to mental health / DARPA / DOD10:54 Picking what to apply with NaNots / Platform technology17:20 Cancer Dogma vs complete picture on combination inhibitors25:00 Individual NaNots vs multiple capture agents / internal debates29:30 Multiple targets / click chemistry31:40 Absorption / nano medicines / cancer38:20 Injecting NaNots and how often43:55 NaNots as a sensor for cancers46:50 Could Theranos have been successful / CTO story to know it was BS53:00 Autodidact / partnering with experts / meritocracy58:45 Finding Experts to partner with / emotional intelligence01:01:15 Elon Musk / Brain teasers / How he assesses in an interview01:03:05 Matt Sholz way to learn / learning / correlation is not enough01:06:30 Autodidact getting people to believe in you / product as the credential01:08:30 How is Raising $100 million going / what he needs help with01:12:40 FDA not seeing them as a device / how to change their minds01:16:55 High net worth individuals01:21:45 Power of Empathy01:25:00 Book recommendations01:26:00 Sci fi / history01:27:55 Band of Brothers / Pacific / Masters of Air01:28:55 How he keeps himself Mentally Healthy01:35:45...

KSQD 01-24-2024: Introduction to mitochondria and related diseases that associate with Long COVID; Practical advice if you have post-COVID syndrome; Mitochondria research related to post-COVID symptoms and nutritional supplements that help; more about chronic fatigue, myalgic encephalitis and long COVID; Does a caller have long COVID? What to check to confirm; The function of neutrophils in autoimmune disease and the benefits of ginger to dampen overreaction of the immune system; A case of retinal dystrophy

What is Aged Garlic Extract (A.G.E.) and how is it different from the garlic we eat? Can this one thing actually lower cholesterol, improve insulin resistance, keep bones strong, boost immunity and detoxification, and prevent dementia? We tend to compartmentalize our bodily systems, but they are all connected and the cardiovascular system is at the head of them all. Learn the science behind how A.G.E. can impact all of our systems, how to take it, how much to take, and what the research actually shows, on this episode of Vitality Radio, where Jared interviews Dr. Jim LaValle all about Kyolic Aged Garlic Extract. You'll learn its many benefits and how to use it to improve your overall health. Dr. Jim LaValle is an internationally recognized clinical pharmacist, author, and board-certified clinical nutritionist, with over 40 years of clinical experience. He is considered a renowned expert in his field.Products:Kyolic Aged Garlic ProductsAdditional Information:#278: The Incredible Benefits of Aged Garlic ExtractLipid tests discussed: NMR LipoProfile® TestCardio IQ®Visit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Our special guest, Julie Ann Davey, RN, MSN, ANP-C, ACNP-C, will discuss how your gut affects your skin? Welcome to Humanized! Each week, we feature top experts in personalized health and functional medicine through engaging interviews and presentations. You'll get practical advice on diet and nutrition, lifestyle, toxins and disease, hormone imbalances, nutrient deficiencies, inflammation, digestive health, mental health, the fast-changing world of genomics, and so much more. All presentations are available as videos, podcasts or transcripts – whichever form is most convenient and enjoyable for you! Visit us at: https://humanizedhealth.com Subscribe to get weekly updates at: https://omniform1.com/signup/v1/5e736dfb8a48f751fdd6aa8a_604bd3c799f0b7086d1de9a4.html

In this episode, we review the high-yield topic of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Recombinant Cytokines⁠ from the Rheumatology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets

In today's episode we talk about gluten. What it is, the symptoms that it can cause (and how it may be involved in health issues you may be experiencing), how to know if it's an issue for you, and what to do about it. Gluten has been something that I've been researching and learning about for more than 20 years. When I was in my training at Bastyr University in the 90s, it wasn't well known that gluten could cause so many health issues. At the time, I, myself was dealing with health issues, including severe allergies and migraines, and I was trying to figure out the cause. I really wanted to understand how my diet and the food I was eating were influencing my health, and so I tried every diet and did every kind of test on myself to try and figure out the cause of my health issues. It wasn't until after having graduated from Naturopathic Medical School that I finally did a test that was able to identify that gluten was an issue for me. And so, I started avoiding gluten and immediately started feeling better. My allergies decreased, the migraines lessened, and I started to feel better in general, so discovering that I have a sensitivity to gluten really helped me. As of now, I have been avoiding gluten for over 20 years and have helped thousands of patients to discover that gluten is an issue for their health as well. I became an expert resource on the topic of gluten and gluten sensitivity, lecturing at professional conferences across the U.S. and being interviewed by the media on numerous occasions. In the process, I learned so much more about the trouble that gluten can cause. And in helping my patients I discovered that it is not just important to identify gluten as an issue, but also how to recover from gluten exposure. This is important because many patients come to me saying they are already avoiding gluten, but they haven't started to feel better yet, and so it's key to know how to do a full recovery from gluten in order to reset your health and to heal. What Is Gluten? Gluten is a protein that is found in certain grains, including barley, rye, spelt and wheat. This protein acts as a binder in recipes, to hold foods that we make with these grains together, and to make them chewy, like the dough in the process of making bread for example. Without gluten, the dough would just crumble and fall apart easily. Gluten is made up of two smaller protein molecules: gliadin and glutenin. I find that it's helpful to understand that these protein molecules are made up of amino acids, just like all protein. When we ingest protein, in general, it is broken down by our pancreatic enzymes into amino acids which can be absorbed into our bodies. The issue with gluten is that humans, in general, are not able to completely digest gliadin (in gluten) and the related prolamins (from wheat, barley, and rye) due to their high glutamine and proline content. That means that when we consume gluten, some amount of it will not be digested, and can become a trigger to our immune system. It's also important to know that there's a whole spectrum of possible reactivities to wheat and gluten, and to understand that we don't all react the same. A person's immune system might be more reactive to gliadin than glutenin, for example, or vice versa. Some people may be equally reactive to both. Others may be more reactive to wheat, which is a larger molecule than gluten. It can be helpful to understand exactly what is triggering your immune system so you know what to avoid specifically. When Is Gluten A Problem? Anytime we eat a food that we don't digest well (like a larger amino acid chain or protein molecule) it has the potential of causing health issues, especially if that undigested food is able to get through the intestinal lining to where our immune system exists, ready to protect us from foreign substances. Our immune system picks up on proteins (remember that viral proteins, like all proteins, consist of amino acids!) and triggers an inflammatory response to attack the protein. This is what can happen with gluten, because we don't digest it well, and because gluten itself opens spaces between intestinal cells, and gets through to where our immune system thinks it needs to protect us from it. Our immune system releases cytokines (which are inflammatory molecules) to try to protect us. Cytokines are important because they help us heal but if our intestines are being constantly bombarded by gluten and cytokines, there will be constant inflammation, and this can end up causing damage to our cells in the long run. Damage to the intestinal cells is called intestinal permeability or leaky gut. For most people, eating gluten occasionally is not a problem. It is more likely to be an issue when we consume gluten all the time. If we're not paying attention, we could even be exposed to gluten in every meal. Some people may be having gluten for breakfast, lunch, dinner, and snacks. Gluten is often added to products and recipes, even when we don't realize it. Besides the grains mentioned above, gluten is added to condiments, recipes and packaged foods that we wouldn't even think would have gluten in them. Some breads, for example, may even contain 10 times more gluten (as an added ingredient) to make them fluffier and chewier. In fact, in the United States we're exposed to more gluten than anywhere else in the world because of the “added gluten” in products, intended to increase sales of these foods. If you are wondering why gluten is such an issue now, it's because we're getting so much more exposed to it than ever before. Additionally, there are other factors, such as that most wheat, especially in the United States, is grown with exposure to a pesticide called glyphosate. Glyphosate is know to damage to the intestinal cells. When you combine the negative effects of glyphosate with the increased exposure to gluten, it makes sense why we are seeing an increase in gluten-related health issues. What is Celiac Disease and How is it Different from Gluten Sensitivity or Wheat Allergy? Let's start with wheat allergy. A wheat allergy is when your immune system is creating IgE antibodies to wheat, similar to when someone is allergic to peanuts. Someone with wheat allergy is likely to develop symptoms within minutes to hours after eating something containing wheat. The symptoms include itching, irritation and swelling of the mouth and throat, hives, itchy rash or swelling of the skin and nasal congestion. This is different from Celiac disease. Celiac disease (CD) is a chronic digestive and autoimmune disorder that damages the small intestine. The disease is triggered by eating foods containing gluten. Celiac can cause long-lasting digestive problems and keep your body from getting all the nutrients it needs. It is an autoimmune condition meaning your immune system is not only trying to protect you from gluten (gliadin), but also from your own intestinal cells. It is thought that at first the immune system is reacting to gluten, and then begins to attack nearby proteins, including an enzyme in intestinal cells called transglutaminase enzyme or tTG. This process ends up damaging the intestinal cells, causing severe leaky gut. About 2% of the population is considered to suffer from Celiac disease. There is a genetic correlation for this disease. We have been able to identify that people who have the genes that are called HLA DQ-2 and HLA DQ-8 have an increased risk of Celiac disease. Those people also have an increased risk of non-Celiac gluten sensitivity. Non-Celiac gluten sensitivity (NCGS or gluten sensitivity) means a person has a reaction to gluten but doesn't have the autoimmunity condition, so the immune system is not attacking their own cells. It is much more common than CD and is thought to occur in at least 6% of the population. Both CD and gluten sensitivity have a lot of health issues associated with them. What Are the Symptoms of Gluten Sensitivity and CD? One of the most common symptoms, especially in children, is a stomachache. GERD/reflux, gastritis, nausea, bowel changes, and abdominal pain are all associated with gluten sensitivity and CD. Headaches are also common. So, if you get a lot of headaches paired with digestive discomfort, you could be suffering from gluten sensitivity. At the same time, it's important to consider that only about 50% of people with Celiac disease and gluten sensitivity have digestive symptoms. Many people come in saying they do not have digestive issues. In fact, with gluten issues it is much more likely to have neurological symptoms, like anxiety, depression, neuropathy, or other neurological issues. The inflammation is going from your digestion straight to your nervous system. Other symptoms include fatigue, brain fog, decreased focus, memory loss and sleep issues. Not only that but gluten can cause aches and pains whether that's joint pain, muscle pain (that might be considered fibromyalgia), and can cause nutrient deficiencies because of the damage to intestinal cells. When we have damage to our intestinal cells, or leaky gut, we're not going to be able to absorb the nutrients from the foods we eat, so we become more likely to have nutrient deficiencies. The most common deficiencies are iron, vitamin D and B vitamins. It may go as far as developing anemia. So, if you have anemia or iron deficiency, you could be suffering from gluten sensitivity. It also can cause canker sores, skin rashes, menstrual issues (including fertility issues), and perimenopausal symptoms. One of the most common issues I find related to gluten is that it increases our risk of infections of all different types - viral infections, bacterial infections, and yeast infections. If you're getting recurrent infections, whether that's sinus infections or bladder infections, vaginitis, skin infections, eye infections and even persistent HPV, it can all be related to gluten. How Can You Know if You Have Gluten Sensitivity or CD? At least one in four people are thought to have some degree of gluten sensitivity. So, how do we test for it? How do we know if we are sensitive to gluten? For Celiac disease, the standard way to diagnose it is with an intestinal biopsy so, you would need to go into the gastroenterologist to have an endoscopy and biopsy. With the biopsy, they're looking for damage to the small intestinal cells caused by the autoantibodies. There is a blood test that shows anti-gliadin antibodies and antibodies to tTG. These tests are part of a Comprehensive Celiac Panel, and can give a sense of whether Celiac exists, but for an official diagnosis of Celiac disease it is necessary to do the biopsy. For non-Celiac gluten sensitivity, the standard is to avoid gluten for a period of time (usually at least three weeks) and monitor your symptoms. If you feel better when you eliminate gluten fully from your diet, then you could have gluten sensitivity. Then you can try re-introducing gluten to your diet and see if you feel worse to confirm if gluten is affecting you. What I find really helps to identify gluten sensitivity is an IgG and IgA food panel. Not all IgA and IgG food panels are as accurate at identifying reactions to gluten, so I recommend using the lab that I have tested and found to provide the most accurate results. You can order this test through my office here. It's a finger poke so you can do it from home anywhere in the world and mail it in. With this test, we can also check for other food that your body may be reacting to – it tests for 96 foods. It is also possible to test for gliadin antibodies in a stool test. The stool test that I recommend to my patients is called the GI Map from Diagnostic Solutions. It is a highly sensitive test for gliadin antibodies in the stool and can identify if your immune system is trying to protect you from gluten. These tests can be helpful even for someone who's been avoiding gluten as they can tell you if your system is still trying to protect you from it based on your current diet. If this is the case, you may want to take a closer look at your diet so you can identify if gluten is sneaking in somehow. What Is Leaky Gut? Leaky gut is a short way of saying intestinal permeability. The mucous lining of our intestines is designed to absorb water and nutrients from our food into our bloodstream. The intestinal cells are lined up next to each other and our body grows new intestinal cells every day. Those intestinal cells can be damaged by stress, injuries, medications, toxins, and gluten. When the intestinal cells are not as healthy, the intestinal lining allows undigested food to “leak” through, causing an inflammatory reaction by our immune system. When we're under a lot of stress, our body is not able to keep up with making new healthy intestinal cells, leading to increased intestinal permeability or leaky gut. Other causes of leaky gut include surgery, physical stress, lack of sleep, exposure to toxins (like pesticides and toxins from gut bacteria), eating non-organic foods, alcohol, caffeine, and gluten. Gluten causes damage to the intestinal cells by triggering the inflammation that we mentioned. It also increases a substance called zonulin which is a protein that signals to open the spaces between the cells. So, gluten is literally signaling through zonulin to cause leaky gut. Then it gets through to the other side of the intestinal lining and that's where our immune system is hanging out waiting to protect us. So, the immune system triggers even more inflammation. And that inflammation doesn't just stay in the intestinal area, it can go anywhere in the body which is why it can cause such broad symptoms. It goes to our nervous system, our joints, our skin, etc. That inflammation then overwhelms our system, causing more stress. So, not only does the stress from our external world make us more likely to have leaky gut and a reaction to gluten, but gluten and the inflammatory response cause more internal stress. And so, it becomes this vicious cycle or snowball effect where it compounds, and you end up with more and more health issues. By doing the food sensitivity panel that I mentioned we can get an assessment of the degree of leaky gut that you may have. To me, that is the real question – is leaky gut mild, moderate or severe. Gluten can also disrupt our microbiome. We've discussed the importance of the gut microbiome in prior episodes. Microbes living in our body are important for maintaining our health in general, our immune system, our nutrient absorption, our neurotransmitters production, etc. If you would like to learn more about how important our microbiome is and how you can get yours back to balance, you can watch Episode 169 of How Humans Heal here. Are Gluten Sensitivity and HPV Related? Through many years helping people with gluten sensitivity, and also helping people with HPV, I have been identified a pattern. Gluten causes leaky gut, and it disrupts the gut microbiome. A disrupted gut microbiome leads to a disrupted vaginal biome, and this causes vaginal inflammation. Vaginal inflammation and a disrupted biome increase the risk of HPV. Also, gluten and leaky gut cause nutrient deficiencies. We know that nutrient deficiencies increase risk of HPV and abnormal cells, and decrease immune function, so it is not able to protect us optimally. Yes, we can work on healing leaky gut, rebalancing your biome, addressing nutrient deficiencies, and supporting your immune system to protect you from HPV. But if we don't take gluten out of your diet, it's just going to recur. It will happen again and again, and that's why I spend so much time in my programs and working with patients to help them successfully eliminate gluten from their diet and fully recover from gluten sensitivity. If you have tested positive for HPV and are ready to get it out of your life for good, I encourage you to join me for an upcoming 5 Days to Heal HPV Live Online Workshop. You can learn more and sign up here. Gluten and Autoimmunity There is also a correlation between autoimmune diseases, such as Hashimoto's, and gluten sensitivity. When there's a reaction to gluten and the immune system starts to protect you from gluten, it can also begin to attack nearby tissue. That's what occurs with Celiac disease and tissue transglutaminase (tTG). Similarly with Hashimoto's, the immune system starts to protect the person from their own thyroid cells. Research shows the relation between gluten sensitivity, leaky gut, chronic inflammation, disrupted microbiome, and disrupted cortisol levels all leading to a likelihood of developing autoimmunity diseases. So, if you're dealing with an autoimmune condition, then I would say it's important to take a look at gluten sensitivity as an underlying cause. How Can We Recover from Gluten? Step one is avoiding gluten, and that's an important step. I have so many resources on helping people avoid gluten I have developed over the past couple of decades. I have written about gluten and how to avoid it in all of my books. I've created recipes and menu plans because I want you to have support. It doesn't have to be a difficult thing if you have the right support. I also like to emphasize that it doesn't need to be an overnight change. You don't have to be stressing yourself trying to avoid all gluten by tomorrow. I wouldn't try to do that. I would look at it as a learning opportunity. Start by finding replacements for common foods in your diet. It's also important to know that most gluten-free products still contain carbs and sometimes more carbs and more sugar than the products containing gluten, and so you don't want to just switch from a gluten filled product to a gluten free product and end up disrupting your blood sugar levels. That's not a good idea either. What we want to do is use this as an opportunity to go more toward a balanced diet where you're having adequate protein, adequate healthy fats and a nice balance of healthy fruits and vegetables, which, by the way, are already gluten-free. We have a lot of food options available that naturally don't have gluten in them. We just need to remind ourselves to choose those foods instead of those containing gluten, or high carbs and sugar. I can help you to start shifting your diet so you have the support you need. I have many programs that help people with this every day. The Stress Warrior Program, for example, including my Stress Remedy 21-day meal plan, that guides you on exactly what to eat for a healthy gluten-free diet. The next step is healing leaky gut. You need to help your body rebuild your intestinal cells. Yes, our body grows new intestinal cells every day but when your body has been constantly bombarded with gluten, and if you've developed severe leaky gut and a disrupted microbiome, then it's going to take some time for those intestinal cells to heal. Often patients tell me they have been avoiding gluten for years, but they still don't feel good. I find that is most often because they have not adequately healed leaky gut. Healing leaky gut involves getting the right enzymes, nutrients and herbs to help your body digest your food better and grow back new healthy cells, decrease inflammation and reestablish a healthy microbiome. If you want to learn more about my protocol to heal leaky gut, you can watch my FREE Heal Leaky Gut Masterclass here. If you are ready to fully heal, you can join my Leaky Gut Online Program here. It includes a food sensitivity panel and support to address your results. Step 3 is to address nutrient deficiencies. It's important to do the right blood test to identify if you have iron, B vitamin, vitamin D, and/or other nutrient deficiencies. These tests are not usually included in standard blood work, but they are tests I can help order so that you get the right information. When you get the right nutrients back into your body and into your cells, you'll be able to fully recover from gluten exposure and improve your health overall. The last step of gluten recovery is to fully reduce inflammation. Remember that gluten is triggering so much inflammation through your whole system, and even if you're avoiding gluten, that inflammation may still exist, especially if you have leaky gut. To decrease inflammation, we need to look at the food sensitivity panel and see if there are other foods in addition to gluten that may be causing inflammation. By avoiding the highly reactive foods, while taking steps to heal leaky guy, you can drop inflammation levels for good. Taking anti-inflammatory herbs and enzymes can help speed up the process. And, of course, we need to address imbalanced cortisol levels in order to fully resolve inflammation. It's about developing a strategy that is unique for your body and the symptoms you are experiencing. We need to understand your health issues and do the right tests to find out what your body needs and how to support it in the best way possible. For those of you who have more severe reactions to gluten, including Celiac disease, and you feel restricted by having to avoid gluten so strictly, and if you potentially have other types of autoimmunity, you may want to consider something called helminthic therapy. This is something that I can talk with you about and help you with as well as it has been shown to reduce severe reactivity to gluten. Personalize Your Recovery From Gluten I want to emphasize that not everyone has to avoid gluten 100%, and not everyone has to avoid it forever. We really have to take it on a case by case basis, and understand how is it reacting in your body, and how it has affected your health, and then help you recover fully. As I mentioned, stress of all types can trigger leaky gut and gluten sensitivity, as well as autoimmunity, and then gluten causes more stress from within the body. Stress then disrupts the HPA (hypothalamic pituitary adrenal axis), adrenal function, and both cortisol and adrenaline levels. A perpetual cycle of stress ensues. This is why I consider recovery from stress to be so important for reversing health issues. If you want to learn more about how stress and trauma have affected you, in terms of your cortisol and adrenaline levels, and how to recover so that you can get back to feeling your best, you may want to read my book Master Your Stress Reset Your Health. To know your Stress Type, which is your unique cortisol and adrenaline levels based on how stresses have affected your adrenal function, you can take the quiz I developed. You can find the Stress Type® Quiz in the book and on my website. If you're ready to start rebalancing your cortisol and neurotransmitters, to help your adrenals reset after stress exposure, you can start by ordering this home test kit. And you can also sign up for my Stress Warrior Online Program to guide you here. If you're interested in a safe and effective body, mind and spirit detoxification that will actually make you feel better and that you can do without affecting your daily routine, you can check out my 14-Day Detox Program here. The Detox Program includes a gluten-free, dairy-free meal plan, along with a protein shake (the protein shake is included), as well as videos to guide you every step of the way. If you're interested in learning more about my approach to addressing HPV, including why healing leaky gut is essential, you can find my HPV Recovery Guide here. If you would like more help getting HPV to negative, and are really committed to erasing it from your life forever, you can sign up for the upcoming 5 Days to Heal HPV Workshop here or my Say Goodbye to HPV 12-Week Program here. To read more blogs about gluten and leaky gut, you can find them here. You can also subscribe to my newsletter, where you'll receive a newsletter from me every Thursday with the latest episode and additional resources and tools for your success with achieving optimal health. For the most comprehensive support, even with the most difficult health issues (physical or mental), it is best to meet with me one-on-one, which is available to you no matter where you are in the world (via phone or zoom). You can set up a one-on-one appointment with me here. We're here to help you! Connect with Dr. Doni:    Facebook HTTPS://FACEBOOK.COM/DRDONIWILSON   Instagram HTTPS://INSTAGRAM.COM/DRDONIWILSON   YouTube HTTPS://YOUTUBE.COM/USER/DONIWILSONND   Weekly Wellness Wisdom Newsletter: HTTPS://DOCTORDONI.COM/WWW     -   Additional Resources:    If you want to work on your gut health and microbiome you may want to sign up for my Heal Leaky Gut Program (https://doctordoni.com/leaky-gut-program) where I teach you how to heal leaky gut with my proven protocol.    If you're interested in learning more about my approach to healing HPV you can find my new HPV Recovery Guide here (https://doctordoni.com/ddpp/hpv-guide/).    If you are tired of this virus and are really committed to erasing it from your life forever, you can sign up for my Say Goodbye to HPV 12-Week Program here (https://drdoni.lpages.co/hpv-12-week-program/).   You can also sign up for my Stress Warrior Program here (https://doctordoni.com/stress-program).    Also, if you want to learn more about how to recover from stress so that you can get back to feeling your best, you may want to read my book Master Your Stress Reset Your Health (https://doctordoni.com/master-your-stress/). In the book, I also share the quiz I developed to help you identify how stress has affected you specifically by knowing your Stress Type. You can also take this Stress Type Quiz online (https://doctordoni.com/quiz/stress-quiz/)   For the most comprehensive support, even with the most difficult health issues (physical or mental), it is best to meet with me one-on-one, which is available to you no matter where you are in the world (via phone or zoom). You can set up a one-on-one appointment with me here (https://doctordoni.com/work-with-me/)   Disclosure: Some of the links in this post are product links and affiliate links and if you go through them to make a purchase I will earn a commission at no cost to you. Keep in mind that I link these companies and their products because of their quality and not because of the commission I receive from your purchases. The decision is yours, and whether or not you decide to buy something is completely up to you.  

Dr. Fahar Merchant, President, CEO, and Co-Founder of Medicenna Therapeutics, talks about the role cytokines play in managing the immune system, activating the system, or dampening the immune response depending on the circumstances.  When the system is out of balance, pathogens and cancers can attack, or autoimmune diseases can occur. MDNA11 is an engineered cytokine or superkine which can be used to effectively deliver drugs to treat a range of solid tumors. in addition, MDNA11 is being fused with a checkpoint inhibitor to both stimulate the immune system and reverse the exhaustion of cancer-fighting immune cells. Fahar elaborates, "Engineered cytokines, or superkines, essentially have been designed so that these molecules are much more effective, they're much safer to administer, and therefore have better outcomes than naturally occurring cytokines. So naturally occurring cytokines tend to be rather small. They clear the kidneys very, very quickly, so they're not in the bloodstream for long enough."  "The other thing is that some of these cytokines can be very toxic when administered in large quantities. Scientists at Stanford University looked at these cytokines. We'll talk about three cytokines, interleukin-2, interleukin-4, and interleukin-13, and thus engineered them in such a way that they can be much more effective, more potent, but at the same time much safer as well. So that's why we call them engineered. That's why we call them superkines because they are much more potent, much more powerful, than our own naturally occurring cytokines floating in our bloodstream." #Medicenna #Oncology #Cancer #Superkines #Cytokines #IL2 #Immunotherapy  Medicenna.com Download the transcript here

Dr. Fahar Merchant, President, CEO, and Co-Founder of Medicenna Therapeutics, talks about the role cytokines play in managing the immune system, activating the system, or dampening the immune response depending on the circumstances.  When the system is out of balance, pathogens and cancers can attack, or autoimmune diseases can occur. MDNA11 is an engineered cytokine or superkine which can be used to effectively deliver drugs to treat a range of solid tumors. in addition, MDNA11 is being fused with a checkpoint inhibitor to both stimulate the immune system and reverse the exhaustion of cancer-fighting immune cells. Fahar elaborates, "Engineered cytokines, or superkines, essentially have been designed so that these molecules are much more effective, they're much safer to administer, and therefore have better outcomes than naturally occurring cytokines. So naturally occurring cytokines tend to be rather small. They clear the kidneys very, very quickly, so they're not in the bloodstream for long enough."  "The other thing is that some of these cytokines can be very toxic when administered in large quantities. Scientists at Stanford University looked at these cytokines. We'll talk about three cytokines, interleukin-2, interleukin-4, and interleukin-13, and thus engineered them in such a way that they can be much more effective, more potent, but at the same time much safer as well. So that's why we call them engineered. That's why we call them superkines because they are much more potent, much more powerful, than our own naturally occurring cytokines floating in our bloodstream." #Medicenna #Oncology #Cancer #Superkines #Cytokines #IL2 #immunotherapy Medicenna.com Listen to the podcast here

In this week's episode, we talk about an aspect of thyroid health that is frequently overlooked, and causes people to suffer as a result. Despite showing classic signs and symptoms, people are told they don't have thyroid problems and that there is nothing wrong with their thyroid. These people fall through the cracks and suffer from thyroid imbalances that can be managed with the proper diet, lifestyle strategies and nutrients.   IN THIS EPISODE: What Is Thyroid Receptor ResistanceIt is an overlooked problem with the thyroid that affects thyroid hormones. Clients oftentimes have low thyroid function despite having normal blood levels and show signs of inflammation, which can be caused by elevation in Cytokines, Leukotrienes, and Interleukins. How Toxins Can Affect The Thyroid Toxins are found everywhere - in the food we eat, the products we use on our skin, and in everyday items we see and use everyday.  These toxins can bind to thyroid receptors, cause damage to cells, and decrease thyroid hormone activity. Why Testing and Retesting Are ImportantIt is important to retest clients, using symptom surveys and labs, every few months so that you can monitor symptoms and their progress to better improve and tweak their recommendations depending on their current state.    RESOURCES: Get our Free Guide with resources to support you in managing clients with Thyroid issues here. Learn How to take a History Test that gets you to root causes with ease and for FREE here.  Access Additional Resources for Practitioners who want to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.   Improve Your Clinical Skills with our recorded 1-day Thyroid Adrenal Workshop here. Learn from our Client Thyroid Program packed with strategies for restoring optimal thyroid function here.

The Root Cause Medicine Podcast is created by Rupa Health, the best way to order, track & manage results from 30+ lab companies in one place for free. The Root Cause Medicine Podcast is a weekly one-on-one conversation with renowned medical experts, specialists, and pioneers who are influencing the way we look at our health and wellbeing. This week we're joined by Brendan Vermeire, Functional Medicine Consultant and Founder of Metabolic Solutions. In this episode, Brendan Vermeire talks about mental health, from depression, anxiety, and neuroinflammation to dementia and Alzheimer's. Brendan is a mental and metabolic health researcher, functional medicine educator, board-certified holistic practitioner, personal trainer, writer, speaker, and host of The Holistic Savage podcast. He is also the owner and founder of the Metabolic Solutions Institute for Functional Health and Fitness Practitioners and the Metabolic Solutions Research & Education Foundation, a not-for-profit foundation dedicated to "changing the way the world views mental health" through advancing the science of mental health dysfunction. Key Takeaways: Debunking the classic psychiatric narrative The current model of mental health treatment in the psychiatric world offers limited treatment options, such as pills or therapy, with little consideration for underlying causes of inflammation or other factors that could contribute to mental health issues. As a result, mental health practitioners like Brendan focus on studying more predominant theories, such as cytokine or neurotrophic ones. Inflammation and mental health symptoms Brendan represents inflammation as "the cleansing fire the immune system uses to fight off pathogens and remodel tissues." Inflammation can be driven by anything, including food, mold, viruses, or pathogens. Most people aren't aware of it, but the average American is inflamed at a low chronic meta-level, which drives the chronic disease epidemic, depression, anxiety, and other mental health issues. The role of neuroplasticity in mental health Neuroplasticity refers to the brain's ability to change and adapt in response to experiences and environmental factors. It is a crucial process that underlies learning, memory formation, and the recovery of function after brain injury. Interventions that promote neuroplasticity, such as cognitive-behavioral therapy, mindfulness-based practices, and physical exercise, effectively improve symptoms of depression, anxiety, and other mental health conditions, which may help to promote positive changes in brain structure and function. How does the microbiome affect mental health? Changes in the microbiome can affect our mental health. Multiple research suggests that the microbiome composition can impact the brain through various mechanisms, including neurotransmitter regulation, inflammation, and immune system modulation. Additionally, some studies have found that a diverse and healthy microbiome is associated with better mental health outcomes. The Mental M.A.P. The Mental M.A.P. (Microglial Activation Profile) is a sophisticated lab panel that assesses the likelihood of microglial activation and neuroinflammation by evaluating multiple serological blood, urine, and even stool markers, as well as other core functions like methylation and nutrient imbalances. Also, check out Brendan's recommended lab testing: The Mental M.A.P., C-reactive protein test, Homocysteine, Thromboxane B2, and Kryptopyrrole Order these tests through Rupa Health - https://www.rupahealth.com/reference-guide

Dr. Trites explains Long Haul Syndrome (long haulers) (Long covid) and why 50% of US will have this and need to know what to do about it. Cytokines in LHS pt 2

In this month's Fertility & Sterility: Unplugged, we take a look at articles from each of F&S's sister journals! Topics this month include: cytokine profiles associated with miscarriage (1:18), a review of blood and urine biomarkers for endometriosis (10:42), and embryonic aneuploidy rates in patients with recurrent pregnancy loss (23:38). F&S Science: https://www.fertstertscience.org/article/S2666-335X(22)00061-1/fulltext  F&S Reviews: https://www.fertstertreviews.org/article/S2666-5719(22)00021-4/pdf   F&S Reports: https://www.fertstertreports.org/article/S2666-3341(22)00108-8/fulltext  View the sister journals at: https://www.fertstertreviews.org https://www.fertstertreports.org https://www.fertstertscience.org

References Dr Guerra's micro RNA lectures FEBS J Volume278, Issue10 May 2011. Pages 1598-1609 International Journal of Molecular Sciences 2013. 14(11):22796-22816 Front. Genet., 07 September 2021 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Episode SummaryChimeric antigen receptors, or CARs, repurpose the build-in targeting and homing signals of our immune system to direct T cells to find and eliminate cancers. Although CAR-T cells have transformed the care of liquid tumors in the circulating blood, like B cell leukemia and lymphoma, CAR-T therapy has shown limited efficacy against solid tumors. To unlock the full potential of CAR-T therapies, better receptor designs are needed. Unfortunately, the space of potential designs is too large to check one by one. To design better CARs, Dan and his co-author Camillia Azimi developed CAR Pooling, an approach to multiplex CAR designs by testing many at once with different immune costimulatory domains. They select the CARs that exhibit the best anti-tumor response and develop novel CARs that endow the T cells with better anti-tumor properties. Their methods and designs may help us develop therapies for refractory, treatment-resistant cancers, and may enable CAR-T cells to cure infectious diseases, autoimmunity, and beyond.About the AuthorDuring his PhD in George Church's lab at Harvard Medical School, Dan studied interactions between bacterial transcription and translation, built and measured libraries of tunable synthetic biosensors, and constructed a new version of the E. coli genome capable of incorporating new synthetic amino acids into its proteins. He also built a high-throughput microbial genome design and analysis software platform called Millstone.As a Jane Coffin Childs Postdoctoral Fellow at UCSF, Dan is currently applying these high-throughput synthetic approaches to engineer T cells for the treatment of cancer and autoimmune disease. He is also working in the Bluestone, Roybal, and Marson labs.Key TakeawaysBy genetically engineering the chimeric antigen receptor (CAR), T cells can be programmed to target new proteins that are markers of cancer, infectious diseases, and other important disorders.However, to realize this vision, more powerful CARs with better designs are needed - current CAR-T therapies have their restraints, including limited performance against solid tumors and lack of persistence and long-term efficacy in patients.An important part of the CAR response is “costimulation,” which is mediated by the 4-1BB or CD28 intracellular domains in all CARs currently in the clinic. Better designs of costimulatory domains could unlock the next-generation of CAR-T therapies.Since there are so many possibilities for costimulatory domain designs, it's difficult to test them all in the lab.Based on his experience in the Church Lab, Dan has developed tools to “multiplex” biological experiments; that is, to test multiple biological hypotheses in the same experiment and increase the screening power.Dan and his co-author Camillia Azimi developed “CAR Pooling”, a multiplexed approach to test many CAR designs at once.Using CAR Pooling, Dan tested 40 CARs with different costimulatory domains in pooled assays and identified several novel cosignaling domains from the TNF receptor family that enhance persistence or cytotoxicity over FDA-approved CARs.To characterize the different CARs, Dan also used RNA-sequencing.ImpactThe CAR Pooling approach may enable new, potent CAR-T therapies that can change the game for solid tumors and other cancers that are currently tough to treat.Highly multiplexed approaches like CAR Pooling will allow us to build highly complex, programmable systems and design the future of cell engineering beyond CAR-T.In addition to new therapeutics, high-throughput studies will allow us to understand the “design rules” of synthetic receptors and improve our understanding of basic immunology.Paper: Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies 

Risa Groux is a Functional Nutritionist and Certified Autoimmune CoachRisa is the author of “Foodframe: Diet Is a Four-Letter Word”, a guide to using functional nutrition to help identify root causes of health issues so that you can eat according to your needs. She also developed the “FoodFrame™ method”, “Risa's Recipes”, and “RGN products” to quickly determine an appropriate nutrition plan based on symptoms and health concerns physically apparent in each person's own body and daily experiences.Risa is a mother, a nutritionist and Certified Coach.In this episode, Risa shares insights into:◈ The 4 Pillars of Functional Nutrition.◈ Why Vitamin D is important.◈ FoodFrame![00:01:31]- Getting into Functional Nutrition.[00:03:48]- 4 Pillars of Functional Nutrition.[00:05:14]- Two foundational health issues.[00:10:17]- Looking at the data.[00:11:10]- Systemic Inflamation.[00:17:00]- Cytokines.[00:18:35]- The importance of vitamin D.[00:24:30]- Food Matters![00:28:18]- See the doctor, get a candy.[00:35:55]- Too little Acid. [00:41:00]- Emotions and diet.[00:44:47]- FoodFrame![00:50:46]- Information is Key.https://www.risagrouxnutrition.com/Please do me a favor, subscribe, leave a positive review on iTunes, follow us on Instagram and share if you know anyone who would benefit from this or other episodes!Do you want to work with me? Reach out and let me know!https://www.instagram.com/youwinninglife/https://www.tiktok.com/@youwinninglifehttps://linktr.ee/jasonwasserlmftThank you for joining me on this ride!Jason Wasser Therapist/CoachOnline Tele-Therapy & Coaching

Regain your freedom from Crohn's, ulcerative colitis, constipation and more in 12 weeks or less without harmful drugs or surgeries. To book a free call and to learn more about working with Dr. Christine, visit: www.bit.ly/gutcall  To purchase Dr. Christine's custom formulations: www.OmegaDigestion.com

In this episode, we review the high-yield topic of Recombinant Cytokines from the Immunology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbulletsIn --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

In this episode, Kyle and Nate discuss the speaker shares advice on how to reduce visceral fat. They recommend trying a coffee enema to regain insulin sensitivity and dropping sugar consumption. Additionally, they discuss how stress and inflammation can lead to weight gain and health problems. The speaker also shares their keto success story. Regain insulin sensitivity, and decrease sugar consumption. They also suggest fasting to help improve insulin sensitivity and lose weight.   [00:00 - 05:52] Is Visceral Fat a Parasite or Parasitic Relationship? Sustainable weight loss is important Sustainable weight loss happens when there is more flexibility in one's lifestyle. Pop quiz!   [05:53 - 08:14] How to Cut Visceral Fat for a Healthier You Visceral fat: active fat that goes underneath the skin, underneath muscles, and around internal organs Endothelial dysfunction: impaired blood flow in the stomach and around organs Organ fat: fat that protects us from organ fat and leads to death if too much is accumulated Cytokines: inflammatory compounds that circulate in the body   [08:15 - 13:16] How to Lose Visceral Fat and Regain Insulin Sensitivity Do your waist to height ratio to determine if you have too much visceral fat Decrease your sugar consumption Start fasting Sustainability is key!   [13:17 - 22:40] How to Release Fat When You're Stressed Decrease toxins in the environment, reduce stress and consume healthy foods. Reducing visceral fat is a key part of reducing inflammation and improving overall health. There is a lot of stress in people's lives, and this can lead to inflammation. To reduce inflammation and improve weight loss, it is important to balance stress and recovery. Some ways to improve stress and recovery include massage, stretching, foam rolling, yoga, meditation, walking, and eating fruits and vegetables.   [22:41 - 29:45] How to Lose Visceral Fat: 3 Simple Tips To lose weight, focus on proteins and fats, especially early in the day when you're moving around. To regain insulin sensitivity, reduce sugar intake and increase walking. Give your body a reason to mobilize and burn fat by decreasing sugar intake and increasing walking. How to Lose Weight without Losing Your Mind   [29:46 - 31:58] Closing Segment The Food and Drug Administration (FDA) may not be giving consumers all the incentives they need to make healthy choices. Check out the free SugarDetox.com to help them start to get more insulin sensitive and free from insulin resistance.   Get lean, get strong, and get paid!     Let me help you reach your goals for FREE, just go to GetNatesBook.Com.  Break your relationship with sugar and drop fat in 5 days at SugarDetox.com, your first step to health. Learn more by connecting with me through Instagram or visit www.LowCarbHustlePodcast.com.      If you liked the show, please LEAVE A 5-STAR REVIEW, like, and subscribe through your favorite streaming platform!     Key Quote   "Whatever you're doing, however, you're trying to get rid of your visceral fat or trying to lose weight, it has to be sustainable." - Kyle Tyler

Are you trying to weigh the pros and cons of possibly using a biologic like Dupixent for your skin condition? Your immune system has such a complex relationship with one another, so it's important to have complete informed consent when starting one. Look into all the side effects- they could be actually helpful, but they could also lead to cancer! My guest today, Heather Zwickey, earned a Ph.D. in Immunology and Microbiology from the University of Colorado and completed a postdoctoral fellowship and taught at Yale University School of Medicine. Dr. Zwickey is recognized internationally as an expert and educator in the fields of integrative medicine, natural therapies and the immune system and has been leading natural medicine research for 20 years. Heather speaks at conferences world-wide, sharing her enthusiasm for naturopathic medicine and science. She currently serves as the Director of Communication and Innovation at Thaena Inc., a microbiome-based company. Join us as we talk about how biologic drugs for chronic skin conditions work. Did you know about the relationship between your immune system and your skin? Let me know in the comments! In this episode: Biologic drugs - what are they, how are they prescribed, and what do they do? Real side effects of biologics - the bad and even the good Breaking down what cytokines are (in layman's terms) Cytokines and the JAK/STAT pathway Discussion of JAK inhibitors (the newest version of biologic drugs for skin issues) Quotes “Back when we used things like methotrexate for skin disorders, we would see that the entire immune system was blocked and as a result, there would be side effects of things like cancer. When we're only blocking one protein, we have much less severe side effects.” [2:59] “If your skin is not in balance with its microbes, it will affect your gut. We really got to address that. That is the root cause, and usually the way that we're going to address that is with eating more plant-based foods and getting some of the toxins out of our system, and letting those microbes grow the way that they were supposed to grow in normal ecosystems.” [17:47]  Links Find Dr. Zwickey online here Healthy Skin Show ep. 180:  How Hormones Impact Your Immune System + Skin Health w/ Heather Zwickey, PhD Healthy Skin Show ep.157: How Your Immune System Can Trigger Skin Rashes w/ Heather Zwickey, PhD Follow Dr. Zwickey on Instagram

About This Episode: Picking up where our Part-1 episode with Dr. Arash Asher left off, Host Bruce Watkins and Dr. Asher dive deeper into factors that cause and/or enhance the common experience of chemo brain, or cancer-related cognitive impairment (CRCI). In this episode, we learn how the experience of chronic loneliness can “up-regulate” our genes to produce more inflammatory agents called Cytokines. In the previous Part-1 episode, Dr. Asher described how these inflammatory cytokines can cross the blood brain barrier and wreak havoc on our concentration and memory.CLICK HERE to Read the FULL SHOW NOTESIf you have not yet listened to the Part-1 episode installment of the interview with Dr. Asher, you can find it here: #015 – What is Chemo Brain, Cytokines & Accelerated Aging – Part 1 – Dr. Arash AsherDirect Link to Episode #015: https://www.ourcancerjourney.com/2022/04/12/015-what-is-chemo-brain-cytokines-accelerated-aging-part-1-dr-arash-asher/ANNOUNCING SEASON 2 of the OCJ Podcast!The improbably positive and up-beat podcast that explores ways to help YOU feel better, live happier, expand your self-empowerment, and enhance your life experience, IS BACK for its 2nd Season! We are so excited about the engaging guests, insightful topics and fun banter in our upcoming line-up that we had to share just a few of the memorable moments with you in advance!! Check out this Season 2 Trailer episode, enjoy the sonic ride, and don't miss a new show by following the Our Cancer Journey Podcast on your apps, by following the OCJ show's Facebook page, or by visiting the Official Our Cancer Journey Podcast Website! Episode Guest:Dr. Arash Asher, MD - Director of Cancer Survivorship & Rehabilitation at the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai. Episode Host: Bruce Watkins:A Father, Cancer survivor, producer, podcaster, writer & content creator, speaker, voice-over artist, facilitator/moderator, avid traveler, cultural explorer, humanitarian, giving-back & minimalist evangelist, music enthusiast, former Corporate people leader, and curious soul who transformed into an unapologetically optimistic and unpretentious advocate of Life-Optimization for all. After surviving Cancer and other life-changing experiences in 2017, Bruce gave away most of his possessions, left his home behind and began traveling, writing, volunteering, and giving back. https://www.ourcancerjourney.com/about-our-cancer-journey-bruce-watkins/https://www.brucewatkins.comhttps://www.linkedin.com/in/brucewatkins/About the Podcast: If you are just discovering the Our Cancer Journey Podcast with Bruce Watkins, …….This Podcast is a place for those impacted with illness, their caregivers, their loved ones, and everyone wishing to prevent illness and enhance their life. Learn more about the Our Cancer Journey Podcast:The Our Cancer Journey Podcast Official Webpage:https://www.ourcancerjourney.com/ Follow Our Facebook Page:https://www.facebook.com/ourcancerjourneypodcastSubscribe for Free to the OCJ Newsletter:https://www.ourcancerjourney.com/contact/

SHR # 2849:: The PEP Talk plus The Story Of Hong Kong - Small device Big Difference - Jean-Francois Tremblay - Bill Mitchell - Brett Jacobson - There's more than one way to skin a cat it's said. And the same is true of managing inflammation. Cytokines became part of the common vernacular due to the recent pandemic. Therapies that suppressed cytokines were shown to have great value increasing survival. But cytokines are harmful in general when they overwhelm the body. This new peptide takes a different approach to quelling the cytokine storm. And may be even more effective. PLUS Bill Mitchell is a gentlemen farmer whos very observant about different governments. He discusses the phenomenon of Benign Neglect which made Hong Kong a powerhouse of a country with no real natural resources in one quarter of the time it took the USA. PLUS A new FDA approved medical device enters the market for treating ED and has some huge benefits. http://shrnetwork.biz/eddie and use code SUPER20 for $20 off.

Here are the notes for episode #367 of Well-Fed Women. Be sure to check back every Tuesday for a new episode, and head over to Apple Podcasts or Stitcher to subscribe!To leave a review for the podcast (HORRAY!), go to: https://coconutsandkettlebells.com/reviewIn this episode, Noelle and Beth O'Hara discuss how to know if you have mast cell activation syndrome.Got a question you'd like us to answer? Email us at wellfedwomen@gmail.com.10% of the funds we receive from our sponsors is donated directly to our partner charity, Thistle Farms, a place where women survivors of abuse, addiction, trafficking and prostitution receive help and support through residential programs, therapy, education, and employment opportunities. Because we get paid per download, you are actively supporting Thistle Farms by downloading our podcast each week.Topics![06:30] How to Know If You Have Mast Cell Activation Syndrome with Beth O'HaraLinks!Noelle's website: https://coconutsandkettlebells.comStefani's website: http://healthtoempower.comBuy our book Coconuts and KettlebellsOrganifiBLUbloxMast Cell 360QuercetinMC260 Precision Mold Master Class: Use code WELLFED for 10% off (expires 4/13/22)Mast Cell Nervous System Reboot: Use code WELLFED for 10% off (expires 4/13/22)Top 8 Mast Cell Supporting Supplements Master Class: Use code WELLFED for 10% off (expires 4/13/22)OrganifiSupport your body, energy, immunity, and stress with Organifi.Organifi takes pride in offering the best tasting superfood products on the market at a price that works out to less than $3 a day.You can experience Organifi's high-quality superfoods without breaking the bank.Go to www.organifi.com/wellfed and use code wellfed for 20% off your order.BLUbloxThe podcast is sponsored by BLUblox. I have become so passionate about light optimization recently, and filtering out computer light and blue light entirely after the sunsets. I wasn't doing anything about this until about a year ago, and I was experiencing eye strain, migraines, and an unexplained wired and tired feeling, especially at night. Now I wear BLUblox computer filter glasses anytime I'm looking at screens, and BLUblox sleep lenses at night, and I haven't experienced symptoms since.BLUblox was created because they saw the need for a product that was exactly in line with the peer-reviewed academic literature. There are a lot of cheaply made lenses out there that don't actually block all the blue and green light. Don't waste your time on that, go to blublox.com/wellfed, and use the code WELLFED for 15% off.