Podcasts about hlh

Conversations in IFN-y explores the latest advancements in understanding and managing secondary hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS), with updates from ASH 2024. Featuring discussions by leading experts, the educational activity covers breakthroughs in diagnostic technologies. Topics covered include AI-based histology models and PET/CT imaging, therapeutic innovations such as emapalumab and reduced-intensity conditioning for HSCT. The implications of these findings for improving outcomes in diverse patient populations, including malignancy- and pregnancy-associated HLH will also be discussed.Launch Date: January 9, 2025Release Date: January 9, 2025Expiration Date: December 31, 2025FACULTYPui Lee, MDAssistant Professor of PediatricsBoston Childrens HospitalAshish Kumar, MD, PhDProfessor of PediatricsCincinnati Children's Hospital Medical CenterAlexei Grom, MDProfessor of PediatricsResearch DirectorDivision of RheumatologyCincinnati Children's Hospital Medical CenterThis podcast provides accredited continuing education credits.  To receive your credit, please read the accreditation information provided in this link prior to listening to this podcast.

BUFFALO, NY- January 7, 2025 – A new #research perspective was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22 on December 9, 2024, entitled “Nuclear lipid droplets: a novel regulator of nuclear homeostasis and ageing.” In this article, Dr. Konstantinos Palikaras from the National and Kapodistrian University of Athens and Dr. Nektarios Tavernarakis from the University of Crete explore how tiny fat droplets, known as nuclear lipid droplets (nLDs), accumulate in the nucleus of cells as we age. Unlike regular lipid droplets, which store energy in the cytoplasm, these nuclear droplets may weaken the nucleus by disrupting critical cellular processes. The authors suggest that excessive buildup of nLDs could lead to nuclear instability and may be linked to metabolic conditions such as fatty liver disease, obesity-related disorders, and premature aging. This highlights the potential role of nLDs in cellular aging and age-related diseases. Previous research by the authors using Caenorhabditis elegans (C. elegans), a model organism commonly used to study aging, revealed the role of ATGL-1, an enzyme that regulates fat storage in the nucleus. When functioning properly, ATGL-1 helps maintain a healthy lipid balance. However, when it becomes inactive or overwhelmed, fat droplets build up around the nuclear lamina, making it more difficult for the cell to function properly. “These findings establish excessive nuclear lipid deposition as a key hallmark of aging, with profound implications for nuclear processes such as chromatin organization, DNA repair, and gene regulation.” The authors emphasize that lifestyle interventions, such as caloric restriction and better insulin regulation, can significantly reduce harmful nLD buildup, reinforcing the role of healthy metabolism in slowing cellular aging. They also call for further studies to understand how nLDs behave in human experimental models, particularly in patients with conditions like metabolic syndrome and progeria. A deeper understanding of these processes could lead to treatments designed to preserve cell health and delay age-related diseases. In summary, by presenting nuclear lipid droplets as potential therapeutic targets, this research perspective presents a new path for exploring treatments aimed at combating age-related diseases driven by lipid dysregulation. DOI - https://doi.org/10.18632/aging.206175 Corresponding authors - Konstantinos Palikaras - palikarask@med.uoa.gr, and Nektarios Tavernarakis - tavernarakis@imbb.forth.gr Video short - https://www.youtube.com/watch?v=vuSLuDk8Xjk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206175 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, ATGL-1, HLH-30/TFEB, lipid droplet, non-linear optical phenomena, nucleus About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

The Running Channel Meets is where we talk to real runners with incredible stories. Each episode we speak with people who inspire us to run, and give our guests an opportunity to tell their stories, often for the first time.Doctors told Prav that running probably saved his life as his running fitness was crucial to his survival. In a two-month hospital stay at North Manchester General Hospital in 2023, Prav Patel overcame a bout of malaria that was three times over the severe infection rate, a rare disease called Hemophagocytic lymphohistiocytosis (HLH) and COVID. Less than six months after being discharged, Prav was taking on a host of gruelling running challenges to raise money in aid of the hospital that saved his life.The Running Channel Meets was born from The Running Channel podcast. Hosted by Sarah Hartley (amateur runner) and Andy Baddeley (former pro runner) alongside Rick Kelsey (recovering runner), the TRC Podcast is friendly, jargon-free, and the perfect accompaniment to your runs.Prav runs for the Manchester Foundation Trust Charity: https://www.justgiving.com/page/byron-day-1704569695291 Join The Running Channel Club for exclusive additional podcast episodes, bite-sized courses, live Q&As and so much more! Head to club.therunningchannel.comFor all enquiries contact podcast@therunningchannel.com .If you liked this, please subscribe wherever you get your podcasts. And leave us a 5* review and rating, it really helps us get discovered.We're on YouTube too, so check us out there: www.youtube.com/runningchannel

This third podcast episode in the series explores advanced understanding of primary hemophagocytic lymphohistiocytosis (HLH), focusing on its genetic basis, diagnostic innovations, and treatment strategies. The discussion highlights the pathophysiology of HLH as an interferon gamma (IFN-γ) driven disease, emphasizing the role of novel diagnostic tools such as flow cytometry and genetic panels. The panel also examines emerging therapies, including JAK inhibitors and IFN-γ monoclonal antibody (emapalumab), in improving outcomes for both primary and secondary HLH. Practical insights into balancing immunosuppression with efficacy offer guidance for optimizing patient care.Launch Date: December 2, 2024Release Date: December 2, 2024Expiration Date: November 30, 2025FACULTYScott Canna, MDAssistant Professor of PediatricsChildrens Hospital of PhiladelphiaPui Lee, MDAssistant Professor of PediatricsBoston Childrens HospitalAshish Kumar, MD, PhDProfessor of PediatricsCincinnati Children's Hospital Medical CenterThis podcast provides accredited continuing education credits.  To receive your credit, please read the accreditation information provided at this link below prior to listening to this podcast.https://www.practicepointcme.com/CMEHome/conversations-in-ifn-y-driven-diseases-decoding-the-gamma-signal-1

In this week's podcast, we'll learn about targeting mutant calreticulin in MPNs, or myeloproliferative neoplasms. Then, it's time to address bleeding and clotting in cancer. Results of the prospective, observational CAT-BLED study provide much needed data on the high risk of clinically relevant bleeding, and its association with all-cause mortality, among cancer patients receiving systemic therapy. Finally, we'll revisit diagnostic guidelines for familial HLH, or hemophagocytic lymphohistiocytosis. The authors present new and improved diagnostic criteria with revised clinical criteria, and guidelines on cellular and genetic diagnostic assays.Featured Articles:Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPNBleeding events in patients with cancer: incidence, risk factors, and impact on prognosis in a prospective cohort studyDiagnostic guidelines for familial hemophagocytic lymphohistiocytosis revisited

Patients with interferon gamma (IFN-γ)-driven diseases such as hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) face significant diagnostic and therapeutic challenges, with delays in diagnosis and limited effective treatments often resulting in poor outcomes. Despite advances in understanding the role of IFN-γ in these conditions, there remains an unmet need for more precise diagnostic tools and faster, targeted therapies to manage the hyperinflammatory states that characterize these diseases.Launch Date: November 25, 2024Release Date: November 25 2024Expiration Date: October 31, 2025FACULTYScott Canna, MDAssistant Professor of PediatricsChildrens Hospital of PhiladelphiaPui Lee, MDAssistant Professor of PediatricsBoston Childrens HospitalAshish Kumar, MD, PhDProfessor of PediatricsCincinnati Children's Hospital Medical CenterThis podcast provides accredited continuing education credits.  To receive your credit, please read the accreditation information provided at this link below prior to listening to this podcast.https://www.practicepointcme.com/CMEHome/conversations-in-ifn-y-driven-diseases-decoding-the-gamma-signal-1

Patients with interferon gamma (IFN-γ)-driven diseases such as hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) face significant diagnostic and therapeutic challenges, with delays in diagnosis and limited effective treatments often resulting in poor outcomes. Despite advances in understanding the role of IFN-γ in these conditions, there remains an unmet need for more precise diagnostic tools and faster, targeted therapies to manage the hyperinflammatory states that characterize these diseases.Launch Date: November 18, 2024Release Date: November 18, 2024Expiration Date: October 31, 2025FACULTYScott Canna, MDAssistant Professor of PediatricsChildrens Hospital of PhiladelphiaPui Lee, MDAssistant Professor of PediatricsBoston Childrens HospitalAshish Kumar, MD, PhDProfessor of PediatricsCincinnati Children's Hospital Medical CenterThis podcast provides accredited continuing education credits.  To receive your credit, please read the accreditation information provided at this link below prior to listening to this podcast.https://www.practicepointcme.com/CMEHome/conversations-in-ifn-y-driven-diseases-decoding-the-gamma-signal-1

What is the HLH Network and how is it improving patient care? In this inaugural episode of our Innovators mini-series, Dr Alexis Jones, Dr Matt Szeto and Dr Denise De Lord join Dr Lizzy MacPhie to talk about the Haemophagocytic Lymphohistiocytosis (HLH) Network, which won a 2024 BSR Best Practice Award. The network brings together specialists from rheumatology, haematology, infectious diseases and more to provide rapid collaborative care for patients with this challenging diagnosis.  Our guests discuss the challenges of diagnosing and caring for patients with HLH, how they set up their own MDT networks to address these challenges locally, their Trusts' improving survival rates, and the new GIRFT HLH pathway.  Want to find out more? There are lots of HLH resources to explore:  Find out more about the team's award-winning project Listen to our HLH spotlight podcast for essential practical tips from Dr Jessica MansonDownload a copy of the new GIRFT pathway and guidance documentVisit the HiHASC website for more resourcesThanks for listening to Talking Rheumatology! Join the conversation on X using #TalkingRheum or tweet us @RheumatologyUK.BSR is the UK's leading specialist medical society for rheumatology and MSK health professionals. To discover how we can support you in delivering the best care for your patients, visit our website.

Guest: Adam Narloch Guest: Michelle Hermiston, MD, PhD Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH) and advances in understanding this rare disease. Dr Hermiston is a pediatric hematologist-oncologist, a bone marrow transplant specialist, and the Director of the Pediatric Immunotherapy Program at UCSF Benioff Children's Hospital. Join us as we start our journey into the world of HLH! © 2024 Sobi, Inc. All Rights Reserved. NP-34329 04/24

Guest: Adam Narloch Guest: Michelle Hermiston, MD, PhD Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH) and advances in understanding this rare disease. Dr Hermiston is a pediatric hematologist-oncologist, a bone marrow transplant specialist, and the Director of the Pediatric Immunotherapy Program at UCSF Benioff Children's Hospital. Join us as we start our journey into the world of HLH! © 2024 Sobi, Inc. All Rights Reserved. NP-34329 04/24

On this episode of The Project Endure Podcast, Joe Rinaldi sits down with Jared Maynard to talk about battling death (HLH) and how powerlifting saved his life, his experience being on life support for 5 weeks (weight loss, organ failure, chemo, etc.), earning the nickname “miracle man," dealing with loss while processing anger, making room for sorrow while trusting God's plan (even when we don't understand), seeing the preciousness of close relationships, developing the skill of listening, the art of employing tactical empathy, learning to disagree without being disagreeable, the meaning of memento mori, lessons from time spent under the bar (barbell), remembering what it feels like to be strong, understanding that anything worth having is hard to get and so much more. Give this episode a listen as we dive deep into Jared's life and learn about what persistence, perspective and endurance mean to him.    If you found value in this episode and would like to help us grow, please leave the podcast a review on your platform of choice and share it with a friend(s). We appreciate your support!   Follow Jared (here)   Follow Project Endure (here) Project Endure Coaching (here) Join The Hard Things Club (here) Shop Project Endure (here)   Follow Joe (here) Read Joe's Blog (here)

In this episode I catch up with new Hands Like Houses vocalist, Josh Raven, post-recovery and pre-tour for his first live shows with the band. This might just be my favourite episode yet, as another bucket-list item checked off! We talk all things HLH, including joining the band and transitioning between projects, vocal techniques, moving into new themes and musical styles, collaborating with old and new friends, Josh's current bookworm reads, and of course preparing for the upcoming tour (starting this week!) and his top 3 current Aussie artists.

Hooked Like Helen returns to the Firelands' Local Music Spot to talk about the release of their new single "Duality (reimagined)" on May 4th. They also released the song "Marigolds" with all the proceeds from the song going to the EB Research Partnership to help children suffering from EB. (https://www.ebresearch.org/) We also debut a new song from Wexford, talk shows around town, Crystal of the Week, a HLH show at the Winchester on May 28th, and their upcoming EP. Additional music from Girl Cologne, Mister Moon, Pocket Vinyl, Virtue Furnace, and Hebdo. The FLMS is brought to you by Oddfellow Photography, The Celestial Black Cat, and HALO Live.

A scientific, groundbreaking approach to happiness and personal fulfillment. In 1979, Dr. Alphonsus Obayuwana was awarded a national research grant and Smith-Kline Medical Perspective Fellowship to develop an instrument for measuring human hope, with the purpose of detecting hopelessness early enough in troubled human individuals so assistance could be offered in time to prevent suicide. The Hope Index Scale (HIS) that resulted from this grant became very popular with Fortune 500 companies and other institutions both in the US and in other countries. This led to the foundation of decades of research that ultimately resulted in this cutting-edge book, The Happiness Formula: Using Science to Understand Personal Satisfaction, Human Hope, and Subjective Well-Being. Unlike other books about happiness, which are too often filled with dos and don'ts, wishful thinking, and empty aphorisms, The Happiness Formula breaks new ground by introducing a universal unit of measure called the “Personal Happiness Index” or PHI. This makes it possible—for the first time ever—to calculate and assign numerical happiness scores to human individuals by plugging their unique hopes, hungers, assets, and aspirations into an equation. Despite its title, The Happiness Formula is much more than a mathematical equation for measuring happiness. It is a book about life; the relationship between human hope and happiness; how to find, measure and boost them; and, most interestingly, how to confirm the happiest country in the world and even help identify the happiest living human, or HLH. It challenges the World Happiness Report of 2023, debunks three major happiness myths, and then introduces the Triple-H Equation—the simple but profound formula about what makes life worth living. This is a book for happiness seekers and happiness advocates everywhere.

Jared Maynard is a PT - Physio & Powerlifting Coach, In 2023 he caught Secondary Hemophagocytic lymphohistiocytosis (HLH) which caused him to be on life support and nearly dying. He had to learn how walk, talk and breathe on his own again.

In this week's episode we'll discuss PAR2-biased signaling in thrombo-inflammation. Then, we'll learn about how hemoglobin levels are linked to survival in transfusion-dependent beta-thalassemia. Finally we'll hear about how etoposide is better than its reputation in primary HLH—hemophagocytic lymphohistiocytosis. Symptomatic patients treated with etoposide have substantially better outcomes as compared to the historical experience.

This week we are incredibly lucky to be joined by Dr Rachel Tattersall, consultant rheumatologist and Co-Chair of HiHASC, to talk about the dangers of Haemophagocytic Lymphohistiocytosis or HLH. This dangerous complication of multiple conditions has an exceptionally high mortality. Fortunately, we have picked Dr Tattersall's brains for all the best ways to identify and treat haemophagocytic lymphohistiocytosis. Tune in to learn more, and hear me try to pronounce the condition out loud!

Mayo Clinic doctor Dr. Connor Bowman faces first-degree murder charges in the death of his wife, Betty Jo Bowman after authorities discovered he allegedly spiked her smoothie with gout medicine. The indictment, issued on January 4, upgraded the initial second-degree murder charge previously filed against Dr. Bowman, according to Minnesota court records. If convicted of the first-degree murder charge, Dr. Connor Bowman could be sentenced to life in prison. Betty Jo Bowman died on August 20, 2023, at a hospital after a four-day stay initially thought to be related to food poisoning. Her health rapidly deteriorated, leading to cardiac issues, fluid in her lungs, and organ failure. Initially attributing her death to a rare illness called hemo-phago-cytic lympho-histio-cytosis (HLH), Dr. Bowman suggested she had prior symptoms. However, investigators found no evidence of HLH in Betty Jo Bowman's medical history. The Southeast Minnesota Medical Examiner's Office raised suspicions about Betty Jo Bowman's death, preventing cremation due to unusual circumstances. A caller, reportedly aware of the couple's marital issues, infidelity, and talk of divorce, alerted authorities. Connor Bowman's behavior raised further suspicion. He urged immediate cremation, claiming his wife's death was natural. However, an acquaintance revealed the couple's relationship struggles and discussions of divorce, prompting investigators to delve deeper. Email correspondence with the medical examiner's office showed Dr. Bowman's interest in the toxicology reports and the extent of testing. With a background in pharmacy and poison control, Dr. Bowman's qualifications intensified concerns among friends and investigators. Financial troubles and infidelity added complexity to the case. Betty Bowman had reportedly mentioned her husband's debt, and friends disclosed details of a $500,000 life insurance policy. Investigators discovered a check matching this amount from an insurance company in the Bowman home. Friends portrayed a troubled marriage, worsened by financial issues and infidelity. Despite an agreement for an open relationship, Betty Bowman allegedly confronted her husband about his new girlfriend, sparking discussions of divorce. Another friend said she was visiting with Betty Bowman 10 days before her death when she gave her a smoothie her husband had made for her. It “tasted very bad,” and the friend thought it was strange Connor Bowman had made a smoothie for his wife because he “never made anything for anybody,” according to the warrant. “[The friend] said jokingly at the time that Connor must be trying to poison her but didn't think much of it at the time. Betty even joked that she had considered it at the time and said she didn't think that would happen but decided not to drink the smoothie anyway and threw it out,” the warrant said. The friend became suspicious when Betty Bowman suddenly became ill and died. Dr. Bowman's demeanor after his wife's death struck friends as unusual. Witnesses claimed he appeared indifferent, even going out for drinks just days later. One friend said she went to see Connor Bowman at his home three days after the death to find the girlfriend there with him and his wife's photos taken down, the warrant said.  The probable cause arrest affidavit said that one of Betty Bowman's boyfriends told detectives that on August 16, she told him she was so sick she could not sleep at all. She said she thought it may have been an alcoholic drink that she had that caused her illness because it was mixed in a large smoothie.   Investigators allege Dr. Bowman used his Mayo Clinic email to purchase colchicine, a drug used to treat gout. He reportedly attempted to shift blame onto his late wife, claiming she fraudulently acquired the drug under his name. Dr. Connor Bowman is set to be arraigned on the new charges on January 16. Want to listen to ALL of our podcasts AD-FREE? Subscribe through APPLE PODCASTS, and try it for three days free: https://tinyurl.com/ycw626tj Follow Our Other Cases: https://www.truecrimetodaypod.com The latest on Catching the Long Island Serial Killer, Awaiting Admission: BTK's Unconfessed Crimes, Delphi Murders: Inside the Crime, Chad & Lori Daybell, The Murder of Ana Walshe, Alex Murdaugh, Bryan Kohberger, Lucy Letby, Kouri Richins, Malevolent Mormon Mommys, Justice for Harmony Montgomery, The Murder of Stephen Smith, The Murder of Madeline Kingsbury, and much more! Listen at https://www.truecrimetodaypod.com

I'm so excited for you to hear this episode because it's exactly the kind of story we all love - one where someone meets a life-threatening challenge and comes out better on the other side.  But there's much more to  Jared Maynard story and it has to do with the importance of being in the right shape to fight for your life. Jared is a Physical Therapist, business owner, powerlifter, strength coach, husband and father of 3 girls who found out how strength training saves lives this year. After spending years in the gym training his mind and body, tragedy struck. He was diagnosed with a rare autoimmune disease called HLH that almost killed him. It took 5 weeks on life support and many months of rehabilitation for him to learn how to walk, talk and breathe on his own again. While on life support, he was so weak that he couldn't receive nutrition for weeks. The muscle he spent years building in the gym became the fuel that sustained him to better days. Now, as Jared continues through recovery, his mission is stronger than ever: To help as many people as possible become so strong that they barely recognize themselves. To help them feel empowered to take on whatever life throws at them. To help them keep showing up for their spouses, kids friends and clients. Jared works full time in his online strength coaching business, Unbreakable Strength, to do exactly that. When he's not working, you can find him reading superhero books with his daughters, sipping on delicious coffee and enjoying life in the Canadian countryside. Pull up a seat at the chef's table and let's dig in. Now, dig into these great offers that help you live your best fitlife: Hexclad Cookware.  Having the right tools makes all the difference in your pursuit of health and your cookware is one of the most important choices you'll make. HexClad makes the most BEAUTIFUL cookware that's also functional, free of harmful chemicals and best in class hybrid technology.  Plus they're easy to clean and maintain - and they come with a lifetime guarantee.  That's Michelin star performance and I'm OBSESSED.  Get up to 30% off with my code CHEFMAREYA at hexclad.com/chefmareya and start cooking like a boss.   www.hexclad.com/chefmareya Orlo Nutrition: There's a new way to get all the omega-3s that you need, and it performs 3X better than fish oil - from sustainably grown clean and pure Icelandic Ultra Algae! You get all the EPA and DHA you need directly from the original source - algae! Your body can't make Omega-3s on their own. That's why they're called ESSENTIAL FATS. You must get them from your diet.  Plus, Orlo gives you two tests to check your Omega 3 levels so you can be sure the supplement is working. GAMECHANGER.  Get 10% off at orlonutrition.com with my code CHEFMAREYA and start powering up your body to the max.  https://orlonutrition.com/discount/CHEFMAREYA The Lumebox Portable IR and Red Light Therapy: It's not from a needle a pill or a prescription. It's infrared and red light therapy and it's changing the way we squash pain, manage mood, energize, help gut health and glow up, naturally.  I'm a big fan of The Lumebox because it's power in a little package and makes traveling with it easy - and it goes with me everywhere.  Hundreds of scientific papers have been written about IR and Red Light and now you can have the ultimate biohack without breaking the bank.  Use my code ChefMareya for up to $250 off The Lumebox at thelumebox.com.  I use it daily!  https://www.lm4bxfgy5d.com/chefmareya/

Haemophagocytic lymphohistiocytosis or HLH, heard of the concept but never certain when it applies? Unsure of how to diagnose or manage it? Listen along as Dr Rohan Mehra (RCP education fellow/Infectious diseases and microbiology SPR) and Dr Alexis Jones (Rhematology consultant, UCLH) discuss a clinical case and provide key points to remember so that you can identify when HLH might be the problem, who to call and what to do to tackle this potentially devastating condition. Linkshttps://www.histiouk.org/https://www.uclh.nhs.uk/our-services/find-service/medical-specialties-1/hlh-servicehttps://www.uptodate.com/contents/clinical-features-and-diagnosis-of-hemophagocytic-lymphohistiocytosis  https://www.mdcalc.com/calc/10089/hscore-reactive-hemophagocytic-syndromeThis podcast has been made with an educational grant from Bristol-Myers Squibb Pharmaceuticals Limited (“BMS”). BMS has had no input or involvement in the design, development or content of the podcast whatsoever. Sound by bensound.com

Take a listen this week for a dive into the world of HLH. We cover primary and secondary HLH, your approach to the diagnosis and workup, as well as management and some info on recent trials. Support the show

Dregin eru fram nokkur erlend lög frá rokkárunum og líka aðeins eldri lög, sem hafa komið út á plötum með íslenskum textum. Flytjendur eru Alfa Beta, Rokkbræður: Garðar Guðmundsson, Þorsteinn Eggertsson og Stefán Jónsson, HLH flokkurinn og Borgardætur. Umsjón: Jónatan Garðarsson.

Dregin eru fram nokkur erlend lög frá rokkárunum og líka aðeins eldri lög, sem hafa komið út á plötum með íslenskum textum. Flytjendur eru Alfa Beta, Rokkbræður: Garðar Guðmundsson, Þorsteinn Eggertsson og Stefán Jónsson, HLH flokkurinn og Borgardætur. Umsjón: Jónatan Garðarsson.

Welcome to episode 050 of the podcast.  In this episode of 3-Minute Thursdays, Histio Ambassador and HLH warrior, Megan Wileman, shares her experience with secondary HLH and how important it is for us to share our stories to raise awareness and know we're not alone. Join us every week and escape for 3 short minutes into a place of hope and encouragement on your histio journey. We'd love to hear your feedback!  Let us know if a 3-Minute Thursday touched you!  Reach out to podcast@histio.org and tell us your thoughts. Music: Walk Together by Olexy --- Support this podcast: https://podcasters.spotify.com/pod/show/histio/support

In this episode, we discuss the management of acute toxicities of CAR T-cell therapy, including CRS, ICANS, and HLH with Dr. Michael Jain from Moffitt Cancer Center.Here are some of the key articles we discussed:1. “How I treat refractory CRS and ICANS after CAR T-cell therapy”.      https://pubmed.ncbi.nlm.nih.gov/36989488/ 2. CAR-HEMATOTOX score:     https://pubmed.ncbi.nlm.nih.gov/34166502/ 3. “How I treat cytopenias after CAR T-cell therapy”.     https://pubmed.ncbi.nlm.nih.gov/36800563/ 4. Immune Effector Cell-Associated HLH-Like Syndrome (ASTCT):    https://pubmed.ncbi.nlm.nih.gov/36906275/ 5. ASTCT consensus grading for CRS and ICANS:    https://pubmed.ncbi.nlm.nih.gov/30592986/6. Hematopoietic stem cell boost for persistent neutropenia after CAR T-cell therapy:    https://pubmed.ncbi.nlm.nih.gov/35696759/ 7. Modified EASIX score for predicting CRS and neurotoxicity:    https://pubmed.ncbi.nlm.nih.gov/34432870/

This week we've invited Dr. Lauren Henderson of Boston Children's Hospital to discuss what Macrophage Activation Syndrome (MAS) is, how to diagnose it and which medications are used to treat it. Dr. Henderson also explains her efforts to partner with healthcare professionals in other fields (who may use a different name for MAS) seeking to understand what treatments they use when confronted with MAS and to establish a formalized process in evaluating and treating these patients together. 

Welcome to episode 044 of the podcast.  In this episode of 3-Minute Thursdays, Histio dad and Histiocytosis Association Ambassador, Mark Ross talks about the power of kind words and how to celebrate National Say Something Nice Day. Join us every week and escape for 3 short minutes into a place of hope and encouragement on your histio journey. Mark is dad to 15-year old Ben, who was diagnosed with CNS isolated HLH.  He is also a Histiocytosis Association Ambassador.  We'd love to hear your feedback!  Let us know if a 3-Minute Thursday touched you!  Reach out to podcast@histio.org and tell us your thoughts. Music: Walk Together by Olexy --- Support this podcast: https://podcasters.spotify.com/pod/show/histio/support

When Vince and Katie Dang found out they were expecting their son Charlie, they never could've imagined the journey that lay ahead. Their story is marked by unimaginable pain, doubt, resilience and hope. Vince and Katie share their experience of navigating the loss of their beloved son, who was diagnosed with Hemophagocytic lymphohistiocytosis (HLH), and how it affected their marriage, faith, and family.In the midst of the loneliness of Charlie's medical journey, and the deep grief following his passing, the Dang's share how they found God's grace to be sufficient for each day as they look toward the day that they will be reunited with their son, Charlie.EPISODE CHAPTERS(0:00:07) - Intro to the Vince and Katie Dang(0:05:03) - A Father's Experience With HLH Disease(0:18:30) - Hope and Faith in Medical Crisis(0:23:22) - Navigating Life With a Sick Child(0:38:02) - Rare Disease Struggle and Faith(0:42:32) - Charlie's Medical Journey(0:48:56) - Fighting for Charlie's Life(0:58:26) - Finding Hope in Difficult Seasons(1:02:50) - Navigating Grief and Hope(1:07:29) - Grief, Identity, and Healing(1:13:01) - Grieving and Finding Strength to Overcome(1:26:05) - Finding Hope in a Broken WorldFOLLOW:InstagramIf you've enjoyed this episode, one of the best ways to support the show and make sure others find it, is to subscribe and leave a review. Thank You!Editing and support by The Good Podcast Co. For sponsorship inquiries, email sponsor@thegoodpodcast.co

Welcome to episode 041 of the podcast.  In this episode of 3-Minute Thursdays, 25th Histio Ambassador, Nate Milam talks about the taking your care into your own hands and the power of the patient voice. Join us every week and escape for 3 short minutes into a place of hope and encouragement on your histio journey. Nate is the 25th Histio Ambassador and an HLH survivor.  We'd love to hear your feedback!  Let us know if a 3-Minute Thursday touched you!  Reach out to podcast@histio.org and tell us your thoughts. Music: Walk Together by Olexy --- Support this podcast: https://podcasters.spotify.com/pod/show/histio/support

Team Flash has a surprise birthday party for Barry with John Diggle and Wally West in attendance. While there, Wally talks about projecting his consciousness into other timelines. Ramsey Rosso arrives and knocks out the guests. He makes Barry feel guilty for getting extra years to live while his friends die and explains to Wally that the timelines are alternate Earths of a reborn multiverse. He takes over Wally's mind and has him kill Barry. Barry awakens in purgatory with Oliver Queen, whom after the Crisis has lived on as the Spectre, watching over and protecting the new multiverse. Oliver helps him accept the guilt he feels and resurrects Barry while temporarily returning with him as Green Arrow. Wally opens a gateway into the multiverse, allowing Rosso to spread his infection. Barry helps Wally break Rosso's influence and Khione restores Diggle, who joins the others in holding off Rosso. This allows Oliver to get a clear shot into the gateway and purge the multiverse of Rosso's infection, which restores everyone. Oliver depowers Rosso and cures his HLH. Afterwards, Oliver explains that Khione is connected to the natural world and says goodbye to Diggle and Barry.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

HLH: 0:00 - 10:30 Draft thoughts through round 3: 10:30 - 41:00 NBA: 41:00 54:00 NHL: 54:00 - 1:06 Tea Party: 1:06

Happy draft season! Hailey took a turn hosting this weeks show so Tyler and Kendra could talk about the draft. HLH: 0:00 - 21:00 Mock Draft: 22:00 - On

Welcome to episode 036 of the podcast.  In this episode of 3-Minute Thursdays, 25th Histio Ambassador, Nate Milam talks about the power of pharmacogenetics and how you can take pain management into your own hands. Join us every week and escape for 3 short minutes into a place of hope and encouragement on your histio journey. Nate is the 25th Histio Ambassador and an HLH survivor.  Resources mentioned in the podcast: Invitae - https://www.invitae.com/en We'd love to hear your feedback!  Let us know if a 3-Minute Thursday touched you!  Reach out to podcast@histio.org and tell us your thoughts. Music: Walk Together by Olexy --- Support this podcast: https://podcasters.spotify.com/pod/show/histio/support

Writer, speaker and creative Frank Jackson lost both his parents at a relatively young age.  His mother died of pancreatic cancer while his father died from HLH, and at age 23 Frank became an orphan.  Frank now finds his meaning, and his ability to be in the moment, through writing and he strives to live up to the moniker Mr. Positive.  To learn more about  Frank and his book the Pearl Effect and other writing projects, visit his website here.  You can also find him on Instagram under the name frank_thefuture.

March 9, 2023 3-Minute Thursday Host – Nate Milam Welcome to episode 029 of the podcast. In this episode of 3-Minute Thursdays, 25th Histio Ambassador, Nate Milam talks about the challenges with ethnicity and matching and how his own match saved his life. Join us every week and escape for 3 short minutes into a place of hope and encouragement on your histio journey. Nate is the 25th Histio Ambassador and an HLH survivor. Resources mentioned in the podcast: · Be the Match - https://bethematch.org/ We'd love to hear your feedback! Let us know if a 3-Minute Thursday touched you! Reach out to podcast@histio.org and tell us your thoughts. Music: Walk Together by Olexy --- Support this podcast: https://podcasters.spotify.com/pod/show/histio/support

In this podcast, our Medical Director, Dr. Brad Lewis, talks with Dr. Scott Canna, from the Division of Rheumatology and the Immune Dysregulation Program at Children's Hospital of Philadelphia. Dr. Lewis and Dr. Canna discuss Hemophagocytic lymphohistiocytosis (HLH); what HLH is, treating and diagnosing HLH, and infections that make you particularly worried about the possibility of HLH developing. Don't forget, Machaon offers genetic testing STAT results in 48 hours!

Liz Brown shares the heartbreaking story of her husband, Daniel, who suffered and eventually lost his life to HLH following his vaccinations. Please visit React 19's website for more information on how to help these incredible people.Please text REACT to 50155 to donate via text 

HLH: 1:32 NFL with Sarah: 12:10 NFL with Tyler: 23:13 Lax: 56:00 NHL: 1:02:00 Pop Culture: 1:18:18 Tea Party: 1:20:00

Dr. Tim Hodges is the Executive Director of the Clifton Strengths Institute and Assistant Professor of Practice in Management at the University of Nebraska. Tim is someone who has a wealth of ideas and is practical in his approach to supporting and leading others. Take a listen to this great conversation and learn a little, laugh a bit, and lead better!   Bio and Contact: Tim Hodges, PhD is the executive director of the Clifton Strengths Institute, professor in the UNL College of Business, and a Gallup-Certified Strengths Coach. He works with individuals and teams to maximize their strengths and increase performance, engagement, and well-being in their education, career, and throughout their lives. Dr. Hodges has enjoyed a 20-year career as a research consultant at Gallup, Inc. His work at Gallup has included leading research projects in strengths development, employee selection and employee engagement with a variety of clients in education and business. Dr. Hodges has delivered hundreds of presentations and written dozens of journal articles, research reports, and academic book chapters.   HLH 115 730 N 14th Street Lincoln, NE 68588-0405 (402) 472-2035 hodges@unl.edu

When I was in the deepest, darkest pit of grief, it was almost impossible for me to think about taking care of myself physically. If you are struggling in this area, today's guest is perfect for you to hear. She is focused on performing self-care every single day. She says that she cannot even imagine going a day without doing some sort of physical activity to help both her mind and body. Lynda's focus on self-care started in a very unusual way. Her daughter, Paige, was sick with mono and within a week became very ill with a disease called HLH (hemophagocytic lymphohistiocytosis), which required hospitalization. Since her daughter was an adult hospitalized during COVID, Lynda could not stay with her constantly. The hospital staff encouraged her to go home each night to care for herself. Lynda said that she would wake up early each morning to call the night nurse to check on Paige. She would then go on a 30-minute walk or run to decompress before going into the hospital for the day to be with Paige.  After 55 days, Lynda's beloved daughter, Paige, died from HLH, but Lynda did not turn away from her self-care. Instead, she poured more of herself into it. She added yoga to her daily routines. Her 30-minute runs turned into 5K runs. She says that she uses this time to process her grief. She said that this daily activity brings her a sense of calm in her day. She finds herself better able to work and care for her family as well. It is truly inspiring. In addition to her personal self-care, Lynda is very focused on raising awareness for HLH both in the medical community and the general population. She and her family have raised money for the Liam's Lighthouse Foundation (https://www.liamslighthousefoundation.org) to help with funding research for this disease. Her hope and prayer is that treatments may improve so that other families do not have to experience this pain.

Leiknar eru upptökur af nokkrum lögum eftir Bobby Darin og Sonny Bono sem hafa komið út í túlkun íslenskra flytjenda. Þar á meðal eru Ragnar Bjarnason, Berti Möller og Anna Vilhjálms, Geimsteinn, Guðrún Gunnarsdóttir og Friðrik Ómar, Lúdó og Stefán, HLH flokkurinn, Hljómsveitin Súlur, Þuríður Sigurðardóttir og Jóhanna Guðrún. Umsjón: Jónatan Garðarsson.

Leiknar eru upptökur af nokkrum lögum eftir Bobby Darin og Sonny Bono sem hafa komið út í túlkun íslenskra flytjenda. Þar á meðal eru Ragnar Bjarnason, Berti Möller og Anna Vilhjálms, Geimsteinn, Guðrún Gunnarsdóttir og Friðrik Ómar, Lúdó og Stefán, HLH flokkurinn, Hljómsveitin Súlur, Þuríður Sigurðardóttir og Jóhanna Guðrún. Umsjón: Jónatan Garðarsson.

Leikin eru lög eftir Neil Sedaka, Carole King og Gerry Goffin sem íslenskir flytjendur hafa hljóðritað og sungið, ýmist á íslensku eða ensku. Flytjendur eru HLH flokkurinn, Lúdó og Stefán, Björgvin Halldórsson, Hljómar, The Boys, Eyjólfur Kristjánsson, Páll Rósinkranz, Rut Reginalds og Erna Gunnarsdóttir. Umsjón: Jónatan Garðarsson.

Leikin eru lög eftir Neil Sedaka, Carole King og Gerry Goffin sem íslenskir flytjendur hafa hljóðritað og sungið, ýmist á íslensku eða ensku. Flytjendur eru HLH flokkurinn, Lúdó og Stefán, Björgvin Halldórsson, Hljómar, The Boys, Eyjólfur Kristjánsson, Páll Rósinkranz, Rut Reginalds og Erna Gunnarsdóttir. Umsjón: Jónatan Garðarsson.

Leikin eru lög eftir Neil Sedaka, Carole King og Gerry Goffin sem íslenskir flytjendur hafa hljóðritað og sungið, ýmist á íslensku eða ensku. Flytjendur eru HLH flokkurinn, Lúdó og Stefán, Björgvin Halldórsson, Hljómar, The Boys, Eyjólfur Kristjánsson, Páll Rósinkranz, Rut Reginalds og Erna Gunnarsdóttir. Umsjón: Jónatan Garðarsson.

HIV, TB, MAC, PCP, HLH...which one is it??

In this week's episode we first review new work revealing the critical role of the tension-sensitive cation channel PIEZO1 in the transendothelial migration of leukocytes. We'll also review new research suggesting that CD8+ T-cells dimly expressing the CD4 antigen are increased in patients with various forms of secondary HLH, a finding that may have diagnostic, prognostic, and therapeutic significance. Finally, we'll review a large, genome-wide association study identifying the ABO O blood group as a novel risk factor for heparin-induced thrombocytopenia—a finding that could have implications for prediction of this syndrome and for the management of related conditions.

Welcome to Episode 017 of the Beyond the Diagnosis Podcast. In this episode Kathy speaks with Michelle Phay, wife of Dave Phay, who lost his life to HLH in 2018. Michelle talks about their experience with the disease, how she navigated through tests, treatments and over 27 different erroneous diagnoses, and how her grief fuels her to fulfill Dave's 3 parting wishes. Let us know what you think! Leave us a review, drop us a comment or share an idea for a future podcast with us at podcast@histio.org. Take a screenshot and tag us @histiocytosis_association on Instagram. We'd love to hear your feedback! Be sure to subscribe so you can be notified the moment a new episode of Beyond the Diagnosis is released. Resources mentioned in the podcast: Grief Resources: www.griefresourcenetwork.com Histio Physicians Directory: https://histio.org/resource-overview/histio-physician-directory/ Music: “Heroes” by Noah Smith

THE FIRST EPISODE OF OUR NEW PODCAST HOLES! Named after my tribe. This week Chloe fills you in on the deets of her mysterious boob covid boob job and the long and arduous journey to her fairy tail ending and huge wangers. We include the real meaning behind the “happy meal boob job” and all you holes need to know about the pros and cons of breast augmentation! Plus of course a little pow wow about this weeks viral Will Smith & Chris Rock slap- with no other than HLH bestie ARMANDO CABBA! You can find him at www.Instagram.com/armandocabba

In this episode, American Journalist, former News Reporter, and HealingStrong podcast co-host Allyson Powell shares her journey in letting the Lord lead after experiencing a difficult loss. Ally and her husband Landon (who currently played Major League Baseball at the time) gave birth to twins, Ellie and Izzy 8 years ago. Izzy was born with a potentially fatal genetic disease called HLH, which required chemotherapy treatment and a bone marrow transplant. Izzy did not survive, and joined her creator just 5 months after she was born. Ally and Landon travel the country telling Izzy's story and how the Lord carried them through that portion of their lives.