Podcasts about variants

In this episode of Talking Drupal, we dive into the world of Drupal user groups and meetups with guests Lee Walker, Bernardo Martinez, and Bo Shipley. Our guests share their experiences in organizing and participating in Drupal communities and the vital role these meetups play in fostering continuous learning and professional development. We also explore the newest features of Drupal Core 11.2 in the Module of the Week. For show notes visit: https://www.talkingDrupal.com/508 Topics Meet the Guests: Lee, Bo, and Bernardo Module of the Week: Drupal Core 11.2 Diving into Drupal User Groups and Meetups Personal Journeys into Drupal User Groups The Role of Meetup.com in Drupal Communities Organizing and Attending Meetups vs. Conferences Challenges and Strategies for Growing Meetups Virtual and Hybrid Meetups: Impact on Attendance Success Tips for Organizing Meetups Keeping Meetups Simple and Engaging Preventing Organizer Burnout Challenges and Changes in Meetup Cadence Finding and Retaining Meetup Members Communication Tools for Meetup Groups The Importance of In-Person Meetups Advice for Starting or Restarting Meetups Conclusion and Contact Information Resources Drupal.org Events The Drop Times Events Meetup.com Drupal Chattanooga Drupal Users Group Chattanooga Drupal Camp Guests Lee Walker - www.codejourneymen.com mr_scumbag Bo Shipley - simplyshipley Bernardo Martinez - linkedin bernardm28 Hosts Stephen Cross - stephencross John Picozzi - epam.com johnpicozzi JD Leonard - modernbizconsulting.com jdleonard Module of the Week with Martin Anderson-Clutz - mandclu.com mandclu Drupal Core 11.2 Single Directory Components (SDCs) have been a focus of excitement for Drupal's front end developers since they were added to Drupal 10.1 as an experimental module, and merged into 10.3 as a stable feature. With Drupal 11.2, SDCs now have a concept of variants, to allow for different ways of presenting a component's information. Some component frameworks like Storybook have a somewhat different concept of variants, which is really a set of property value presets that are useful for testing. Variants with Drupal SDCs strike me as being analogous to view modes for content types, in that you can have separate template files for each variant, or you can have conditional logic within a single template based on the variant in use. Our own nicxvan, chx, and some others put some significant work into allowing preprocess hooks to be defined as OOP classes, which bring us a significant step closer to not needing .module files anymore. Hooks (and .module files) are Drupalisms, so removing the need for them is a big improvement for Developer Experience, and makes it easier for developers to get started with Drupal In Drupal 11.2 the module installer has been updated to only rebuild the container after several modules have been installed, which significantly speeds up installing multiple modules at once. Drupal 11.2 also brings us a Recipe Unpack composer extension, so when you composer require a recipe, the dependencies get automatically added to your site's composer.json file, so you can apply and then remove the recipe and still have a fully functional site Package Manager is now a hidden module in Drupal core, which is critical for initiative like Automatic Updates and Project Browser, that the community has been working on for years Drupal core now also supports the next-generation AVIF format, with WEBP as a fallback with servers that don't support generating them Of course there are also a variety of dependency updates as well, for CKEDitor, Symfony, composer and more, as well as too many minor improvements and bugfixes to cover in detail here

BUFFALO, NY — June 12, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 5, on May 3, 2025, titled “APOE genotype and biological age impact inter-omic associations related to bioenergetics.” In this study, led by first author Dylan Ellis and corresponding author Noa Rappaport from the Institute for Systems Biology, researchers discovered that different versions of the APOE gene—particularly ε2 and ε4—are linked to metabolic patterns associated with aging and Alzheimer's disease risk. Both variants were linked to increased levels of diacylglycerols, a type of fat molecule connected to insulin resistance and inflammation, suggesting shared disruptions in how the body regulates energy. The research team analyzed data from over 2,200 adults without an Alzheimer's diagnosis, exploring how APOE genotypes influence biological age, a measure of health that reflects how quickly or slowly someone is aging at a cellular level. They found that the same metabolic disturbances seen in ε2 carriers were also present in people considered biologically older, revealing unexpected overlap between genetic risk and aging-related metabolic changes. To examine these connections in more detail, the researchers used a multi-omics approach, combining blood-based metabolism and protein data, gut bacteria analysis from stool samples, and clinical chemistry data. This method allowed them to map how genetic differences and biological aging affect the body's energy systems. They observed altered connections between glucose metabolism, inflammatory markers, and key molecules that play roles in energy production, indicating early disruptions that could contribute to age-related diseases. One of the study's surprising findings was that the ε2 variant, usually associated with longer life and reduced Alzheimer's risk, showed metabolic traits similar to those found in insulin-resistant individuals. This suggests that ε2 may carry metabolic disadvantages earlier in life, with its protective effects becoming more pronounced later. Conversely, ε4—linked to greater Alzheimer's risk—may exert its influence based on interactions with lifestyle factors like diet, sex, and overall health status. “‘Omics association patterns of ε2-carriers and increased biological age were also counter-intuitively similar, displaying significantly increased associations between insulin resistance markers and energy-generating pathway metabolites.” By identifying these shared biological signatures, this study offers a new framework for understanding how genes and metabolism work together to influence aging. These findings could support more personalized health strategies aimed at delaying biological aging and reducing the risk of chronic diseases. As aging populations grow worldwide, understanding these pathways is essential to improving healthspan. DOI - https://doi.org/10.18632/aging.206243 Corresponding author - Noa Rappaport - noa.rappaport@isbscience.org Video short - https://www.youtube.com/watch?v=75hZQoO5U0U Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206243 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, apolipoprotein E (APOE), biological age, metabolism, Alzheimer's disease (AD), insulin resistance To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

In today's episode, we tweak some existing pokemon to make fun and interesting variants! Guess what?! One of us goes mechanics, one goes goofy fun!Intro/Outro music: https://commons.nicovideo.jp/material/nc163920

The Ars Magica roleplaying game is currently complete, but the community is still mining great gaming material out of medieval history as part of a Share Alike License. The Games From Folktales podcast gives you new, odd, useful material each week, for roleplaying games set in European-styled fantasy settings.   Mythic Europe Magazine is now available from Drivethru, Patreon and itch.io. https://www.patreon.com/c/timothyferguson/shop https://timothy-ferguson.itch.io/mythic-europe-magazine-issue-one https://www.drivethrurpg.com/en/product/520248/Mythic-Europe-Magazine-Issue-One?affiliate_id=1776916

Covid-19 : le Dr Khodabocus appelle à la prudence face au risque de nouveaux variants by TOPFM MAURITIUS

Un nouveau variant de la Covid-19 fait des ravages en Asie et des nouveaux cas ont été détectés dans plusieurs aéroports des États-Unis. Est-ce que ce nouveau variant est inquiétant pour les Québécois? Entrevue avec Dr Luc Boileau, directeur national de santé publique du Québec. Regardez aussi cette discussion en vidéo via https://www.qub.ca/videos ou en vous abonnant à QUB télé : https://www.tvaplus.ca/qub ou sur la chaîne YouTube QUB https://www.youtube.com/@qub_radio Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

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The Rebbe responds to an editorial suggestion, defending his deliberate use of a less common version referencing food purity in Egypt. He explains that uncommon variants often reflect deeper intent and clarity, not error, and that changing them risks distorting the message—especially in light of contemporary challenges to kashrus in Eretz Yisrael. https://www.torahrecordings.com/rebbe/igroskodesh/015/009/5433

Explains language models (LLMs) advancements. Scaling laws - the relationships among model size, data size, and compute - and how emergent abilities such as in-context learning, multi-step reasoning, and instruction following arise once certain scaling thresholds are crossed. The evolution of the transformer architecture with Mixture of Experts (MoE), describes the three-phase training process culminating in Reinforcement Learning from Human Feedback (RLHF) for model alignment, and explores advanced reasoning techniques such as chain-of-thought prompting which significantly improve complex task performance. Links Notes and resources at ocdevel.com/mlg/mlg34 Build the future of multi-agent software with AGNTCY Try a walking desk stay healthy & sharp while you learn & code Transformer Foundations and Scaling Laws Transformers: Introduced by the 2017 "Attention is All You Need" paper, transformers allow for parallel training and inference of sequences using self-attention, in contrast to the sequential nature of RNNs. Scaling Laws: Empirical research revealed that LLM performance improves predictably as model size (parameters), data size (training tokens), and compute are increased together, with diminishing returns if only one variable is scaled disproportionately. The "Chinchilla scaling law" (DeepMind, 2022) established the optimal model/data/compute ratio for efficient model performance: earlier large models like GPT-3 were undertrained relative to their size, whereas right-sized models with more training data (e.g., Chinchilla, LLaMA series) proved more compute and inference efficient. Emergent Abilities in LLMs Emergence: When trained beyond a certain scale, LLMs display abilities not present in smaller models, including: In-Context Learning (ICL): Performing new tasks based solely on prompt examples at inference time. Instruction Following: Executing natural language tasks not seen during training. Multi-Step Reasoning & Chain of Thought (CoT): Solving arithmetic, logic, or symbolic reasoning by generating intermediate reasoning steps. Discontinuity & Debate: These abilities appear abruptly in larger models, though recent research suggests that this could result from non-linearities in evaluation metrics rather than innate model properties. Architectural Evolutions: Mixture of Experts (MoE) MoE Layers: Modern LLMs often replace standard feed-forward layers with MoE structures. Composed of many independent "expert" networks specializing in different subdomains or latent structures. A gating network routes tokens to the most relevant experts per input, activating only a subset of parameters—this is called "sparse activation." Enables much larger overall models without proportional increases in compute per inference, but requires the entire model in memory and introduces new challenges like load balancing and communication overhead. Specialization & Efficiency: Experts learn different data/knowledge types, boosting model specialization and throughput, though care is needed to avoid overfitting and underutilization of specialists. The Three-Phase Training Process 1. Unsupervised Pre-Training: Next-token prediction on massive datasets—builds a foundation model capturing general language patterns. 2. Supervised Fine Tuning (SFT): Training on labeled prompt-response pairs to teach the model how to perform specific tasks (e.g., question answering, summarization, code generation). Overfitting and "catastrophic forgetting" are risks if not carefully managed. 3. Reinforcement Learning from Human Feedback (RLHF): Collects human preference data by generating multiple responses to prompts and then having annotators rank them. Builds a reward model (often PPO) based on these rankings, then updates the LLM to maximize alignment with human preferences (helpfulness, harmlessness, truthfulness). Introduces complexity and risk of reward hacking (specification gaming), where the model may exploit the reward system in unanticipated ways. Advanced Reasoning Techniques Prompt Engineering: The art/science of crafting prompts that elicit better model responses, shown to dramatically affect model output quality. Chain of Thought (CoT) Prompting: Guides models to elaborate step-by-step reasoning before arriving at final answers—demonstrably improves results on complex tasks. Variants include zero-shot CoT ("let's think step by step"), few-shot CoT with worked examples, self-consistency (voting among multiple reasoning chains), and Tree of Thought (explores multiple reasoning branches in parallel). Automated Reasoning Optimization: Frontier models selectively apply these advanced reasoning techniques, balancing compute costs with gains in accuracy and transparency. Optimization for Training and Inference Tradeoffs: The optimal balance between model size, data, and compute is determined not only for pretraining but also for inference efficiency, as lifetime inference costs may exceed initial training costs. Current Trends: Efficient scaling, model specialization (MoE), careful fine-tuning, RLHF alignment, and automated reasoning techniques define state-of-the-art LLM development.

Interview with Leonoor F. J. M. Wijdeveld, BSc and Sean J. Jurgens, MD, MSc, PhD, authors of Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation. Hosted by Sharlene Day, MD. Related Content: Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation Genetic Testing in Early-Onset Atrial Fibrillation

Interview with Leonoor F. J. M. Wijdeveld, BSc and Sean J. Jurgens, MD, MSc, PhD, authors of Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation. Hosted by Sharlene Day, MD. Related Content: Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation Genetic Testing in Early-Onset Atrial Fibrillation

The scientific method involves observation, questioning, forming hypotheses, testing predictions and altering theories to align with results; it is not the altering of results to align with a hypothesis.  There are three acceptable narratives about COVID-19: a wet mart (official), 5G (conspiracy), and laboratory leak (alternative). Whereas the https://www.science.org/content/article/cia-bribed-its-own-covid-19-origin-team-reject-lab-leak-theory-anonymous-whistleblower to reject the lab theory, https://apnews.com/article/covid-cia-trump-china-pandemic-lab-leak-9ab7e84c626fed68ca13c8d2e453dde1 explanation. This announcement was made just days after the former President regained the White House. As of April 2025, the https://www.whitehouse.gov/lab-leak-true-origins-of-covid-19/?fbclid=IwY2xjawJv5wdleHRuA2FlbQIxMAABHrhaCm1LYQx2UbG8uGLw5gkhCvB3N4a2gNrAgdarT7Z6C-XKZijSXHb3PctU_aem_hUJWc6XJ_Gfj14AvDa1VSA as “the true origins of COVID-19.”  This new official designation means that at one time or another two totally different explanations were given, ultimately with the consequence of censorship and ridicule if a person thought or said anything different. Both explanations still result in justufciaotn for past, and future, measures such as: social distancing, masking, https://www.theatlantic.com/ideas/archive/2021/04/end-hygiene-theater/618576/ as a form of a theater, vaccines, etc.  Prior to the recent shift in narratives, undercover video reportedly proved that Pfizer was indeed conducing gain of function research in a laboratory. But that lab was not a viral facility or a Wuhan institute; instead, it was a computer lab. In fact, https://www.pfizer.com/news/announcements/pfizer-responds-research-claims stating: “With a naturally evolving virus, it is important to routinely assess the activity of an antiviral. Most of this work is conducted using computer simulations…” Such computer simulations were used to predict mass casualties from COVID, too, and are the same ones being employed for Climate Change narratives. But what is COVID-19 or the virus designated SARS-COV-2. It is a list or complex of symptoms that are classified into categories of disease. Examination of COVID's symptoms prove they are nearly identical to the common cold and flu, among others. In fact, the https://hsph.harvard.edu/news/a-sharp-drop-in-flu-cases-during-covid-19-pandemic/. According to Harvard, this was the result of “wearing masks and distancing,” though they did not explain how such measures stopped the flu but not SARS-COV-2. Consider these three sets of symptoms from the CDC website: https://www.cdc.gov/common-cold/about/index.html: runny nose or nasal congestion, cough, sneezing, sore throat, headache, mild body aches, fever.https://www.cdc.gov/flu/signs-symptoms/index.html: runny or stuffy nose, cough, sore throat, headaches, muscle or body aches, fatigue, fever, and vomiting or diarrhea.  https://www.cdc.gov/covid/signs-symptoms/index.html: congestion or runny nose, cough, sore throat, headache, muscle or body aches, fatigue, fever or chills, nausea or vomiting, and diarrhea.  The only distinct symptoms of COVID were “shortness of breath or difficulty breathing” and “new loss of taste or smell.” The first symptom is already https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm in the United States - chronic lower respiratory disease. Since COVID was first tested CLRD has been bumped to sixth, though many of these respiratory deaths have been listed as COVID. In other words, what would have been diagnosed as CLRD was categorized instead as COVID-19. This is the same reason flu nearly disappeared as reported cases. These breathing problems were, within the COVID diagnosis, themselves sub-categorized as COVID-Pneumonia, and https://my.clevelandclinic.org/health/diseases/24002-covid-pneumonia.   The second symptom of losing a senes of taste or smell varied between total loss and partial loss, something that also occurs with the common cold and flu. This distinct and often promoted https://www.healthline.com/health-news/who-is-most-likely-to-lose-their-sense-of-smell-and-taste-from-covid-19, and even so only involved some often minor or unspecified form of loss.  Thus we can determine that between 15-37% of COVID cases had “distinct” symptoms arguably different than the overall symptoms that classify cold or flu, which means at liberal estimates over two thirds of COVID cases were nothing more than a case of the cold or flu. When defining what caused these other symptoms, we know recategorized pneumonia was one. But what about other causes that resulted in loss of senses?  Other than injuries or inflammation, often caused by what we call allergies, https://www.livestrong.com/article/13731552-food-suddenly-tastes-different/ and https://pubmed.ncbi.nlm.nih.gov/27178656/, as can neurological disorders. Other than the obvious and physical, there is also the psychological. Anxiety and stress are well known to alter sense perceptions, including https://www.calmclinic.com/anxiety/signs/smell and https://pmc.ncbi.nlm.nih.gov/articles/PMC10668578/. Consider how much anxiety and stress were cultivated by 24-hour coverage of cases, deaths, symptoms, videos from China, etc., and how wiling the public was to adopt any perceptually legal or even illogical dictate for the purposes of keeping themselves and others “safe.” There is a long history of such mass psychogenic pathogen.Much of this fear was generated by variant names like “KRAKEN,” a mythical monster, as was https://www.unmc.edu/healthsecurity/transmission/2023/09/19/meet-the-man-who-named-covids-new-variants/ who likewise believed this naming heightened the public's perception of a terror they should be feeling. Such fear became so intense that one analysis suggested that COVID activated “archetypes of evil” and thus “added psychological suffering.” The study suggested: “Fear and grief caused by the pandemic have produced a powerful unconscious narrative in the collective psyche that the coronavirus is driven by an https://pmc.ncbi.nlm.nih.gov/articles/PMC8441919/. The resulting archetypal dimension of fear causes an extra layer of psychological suffering in individuals.”  Such mythical, theological, and even magical terms were not lost in the New England Journal of Medicine which openly declared in 2020 that masks were little more than talismans: “Masks are not only tools, https://www.nejm.org/doi/full/10.1056/NEJMp2006372...” A spirit or demon possessing a body is an impure form that makes one sick. Items such as crosses or holy water are employed in its exorcism - to exercise/exorcise the demon and make healthy again - along with the name of the unclean. The same is done today in modern vaccine administration. The holy water is replaced by a vaccine vial, the cross is replaced by a syringe and plunger, the demon's name is replaced by the variant or virus name, and the ritual robes are replaced by white lab coats.  The pandemic was not about a virus and a distinct set of symptoms. Instead it was about inducing archetypical fear and https://www.weforum.org/stories/2020/10/the-rich-got-richer-during-the-pandemic-and-that-s-a-daunting-sign-for-our-recovery/. It was at best https://www.history.com/articles/mysterious-illnesses-mass-hysteria, in the middle a conspiracy of fraud and psychological terror, and at worst a dark magical ritual to induce trauma.  Further evidence of the fraud can be found in reports like this one from the New York Times that discuss the ultra amplification of PCR testing cycles from the low 30s to the mid 40s -“https://absa.org/wp-content/uploads/2020/09/NYT-200829-Your-Coronavirus-Test.pdf” - “In three sets of testing data that include cycle thresholds, compiled by officials in Massachusetts, New York and Nevada, up to 90 percent of people testing positive carried barely any virus…In Massachusetts, from 85 to 90 percent of people who tested positive in July with a cycle threshold of 40 would have been deemed negative if the threshold were 30 cycles.”  Even ‘true' positive tests do not indicate symptoms or disease, or the future development of such, which brings us back to the White House website and the statement about the lab leak: “The virus possesses a biological characteristic that is not found in nature.” This may be true, as per whatever is being assumed to exist, or observed under a microscope, or played with in a computer model, yet it does not prove any disease, especially in https://abcnews.go.com/Health/covid-transmission-asymptomatic/story?id=84599810. *The is the FREE archive.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-secret-teachings--5328407/support.

In this week's episode we'll learn more about how phosphoseryl-tRNA kinase inhibition promotes cell death in acute myeloid leukemia, or AML; APOE gene variants and their association with post-hematopoietic stem cell transplant outcomes in AML; and pathways by which chronic inflammation and oxidative stress may lead to cardiomyopathy in patients with sickle cell disease.Featured Articles:PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells Common Hereditary Variants of the APOE Gene and Posttransplant Outcome in Acute Myeloid Leukemia 17R-Resolvin D1 Protects Against Sickle Cell Related Inflammatory Cardiomyopathy in Humanized Mice 

Philosophers have for over two millennia debated the irresistible force paradox, usually formulated as ‘What happens when an unstoppable force meets an immovable object?' Variants of the problem date back as far as China in the third century BCE and ancient Greece. The world got one answer to the question on March 26, 2024, when a Singapore-flagged boxship hit the Francis Scott Key Bridge that spanned Baltimore harbour in the US. The vessel was inevitably damaged, the bridge collapsed, and six people from a maintenance crew working on the bridge at the time were killed. Within days, the owners and managers of Dali filed for limitation of liability. If their suit is successful, Grace Ocean, Synergy Marine and their insurers will pay out no more than $44m. In this edition of the podcast, Lloyd's List insurance and law editor David Osler unpacks what happens next in what could turn out to be one of the costliest marine casualties of all time.

In this episode I discuss the following ⭐️ DJ Spin .. I discuss high voltage and what makes it kind of boring.. also i go over this months cards so far (high expectations can lead to disappointment). ⭐️ Listener questions (thank you to both who sent them this week! ) please send me YOURS via my X/ Blusky or my discord !! ⭐️ my week in snap & what's in the shop with where I am for the month.. how has the climb been? Decks I've played , variants , bundles and more! ⭐️ Strange Supreme in comics corner (no comic presence just the origin from what if ) Also a look at the new books in the marvel unlimited app⭐️ MCU minute with a daredevil finale review and my thoughts on the entire season/ early (non spoiler) reviews from people who pre screened Thunderbolts, Fantastic Four promo art and the rest of the MCU projects coming out this year!

Listen in as Real Science Radio host Fred Williams and co-host Doug McBurney review and update some of Bob Enyart's legendary list of not so old things! From Darwin's Finches to opals forming in months to man's genetic diversity in 200 generations, to carbon 14 everywhere it's not supposed to be (including in diamonds and dinosaur bones!), scientific observations simply defy the claim that the earth is billions of years old. Real science demands the dismissal of the alleged million and billion year ages asserted by the ungodly and the foolish.     * Finches Adapt in 17 Years, Not 2.3 Million: Charles Darwin's finches are claimed to have taken 2,300,000 years to diversify from an initial species blown onto the Galapagos Islands. Yet individuals from a single finch species on a U.S. Bird Reservation in the Pacific were introduced to a group of small islands 300 miles away and in at most 17 years, like Darwin's finches, they had diversified their beaks, related muscles, and behavior to fill various ecological niches. Hear about this also at rsr.org/spetner.  * Finches Speciate in Two Generations vs Two Million Years for Darwin's Birds?  Darwin's finches on the Galapagos Islands are said to have diversified into 14 species over a period of two million years. But in 2017 the journal Science reported a newcomer to the Island which within two generations spawned a reproductively isolated new species. In another instance as documented by Lee Spetner, a hundred birds of the same finch species introduced to an island cluster a 1,000 kilometers from Galapagos diversified into species with the typical variations in beak sizes, etc. "If this diversification occurred in less than seventeen years," Dr. Spetner asks, "why did Darwin's Galapagos finches [as claimed by evolutionists] have to take two million years?" * Opals Can Form in "A Few Months" And Don't Need 100,000 Years: A leading authority on opals, Allan W. Eckert, observed that, "scientific papers and textbooks have told that the process of opal formation requires tens of thousands of years, perhaps hundreds of thousands... Not true." A 2011 peer-reviewed paper in a geology journal from Australia, where almost all the world's opal is found, reported on the: "new timetable for opal formation involving weeks to a few months and not the hundreds of thousands of years envisaged by the conventional weathering model." (And apparently, per a 2019 report from Entomology Today, opals can even form around insects!) More knowledgeable scientists resist the uncritical, group-think insistence on false super-slow formation rates (as also for manganese nodules, gold veins, stone, petroleum, canyons and gullies, and even guts, all below). Regarding opals, Darwinian bias led geologists to long ignore possible quick action, as from microbes, as a possible explanation for these mineraloids. For both in nature and in the lab, opals form rapidly, not even in 10,000 years, but in weeks. See this also from creationists by a geologist, a paleobiochemist, and a nuclear chemist. * Blue Eyes Originated Not So Long Ago: Not a million years ago, nor a hundred thousand years ago, but based on a peer-reviewed paper in Human Genetics, a press release at Science Daily reports that, "research shows that people with blue eyes have a single, common ancestor. A team at the University of Copenhagen have tracked down a genetic mutation which took place 6-10,000 years ago and is the cause of the eye color of all blue-eyed humans alive on the planet today." * Adding the Entire Universe to our List of Not So Old Things? Based on March 2019 findings from Hubble, Nobel laureate Adam Riess of the Space Telescope Science Institute and his co-authors in the Astrophysical Journal estimate that the universe is about a billion years younger than previously thought! Then in September 2019 in the journal Science, the age dropped precipitously to as low as 11.4 billion years! Of course, these measurements also further squeeze the canonical story of the big bang chronology with its many already existing problems including the insufficient time to "evolve" distant mature galaxies, galaxy clusters, superclusters, enormous black holes, filaments, bubbles, walls, and other superstructures. So, even though the latest estimates are still absurdly too old (Google: big bang predictions, and click on the #1 ranked article, or just go on over there to rsr.org/bb), regardless, we thought we'd plop the whole universe down on our List of Not So Old Things!   * After the Soft Tissue Discoveries, NOW Dino DNA: When a North Carolina State University paleontologist took the Tyrannosaurus Rex photos to the right of original biological material, that led to the 2016 discovery of dinosaur DNA, So far researchers have also recovered dinosaur blood vessels, collagen, osteocytes, hemoglobin, red blood cells, and various proteins. As of May 2018, twenty-six scientific journals, including Nature, Science, PNAS, PLoS One, Bone, and Journal of Vertebrate Paleontology, have confirmed the discovery of biomaterial fossils from many dinosaurs! Organisms including T. Rex, hadrosaur, titanosaur, triceratops, Lufengosaur, mosasaur, and Archaeopteryx, and many others dated, allegedly, even hundreds of millions of years old, have yielded their endogenous, still-soft biological material. See the web's most complete listing of 100+ journal papers (screenshot, left) announcing these discoveries at bflist.rsr.org and see it in layman's terms at rsr.org/soft. * Rapid Stalactites, Stalagmites, Etc.: A construction worker in 1954 left a lemonade bottle in one of Australia's famous Jenolan Caves. By 2011 it had been naturally transformed into a stalagmite (below, right). Increasing scientific knowledge is arguing for rapid cave formation (see below, Nat'l Park Service shrinks Carlsbad Caverns formation estimates from 260M years, to 10M, to 2M, to it "depends"). Likewise, examples are growing of rapid formations with typical chemical make-up (see bottle, left) of classic stalactites and stalagmites including: - in Nat'l Geo the Carlsbad Caverns stalagmite that rapidly covered a bat - the tunnel stalagmites at Tennessee's Raccoon Mountain - hundreds of stalactites beneath the Lincoln Memorial - those near Gladfelter Hall at Philadelphia's Temple University (send photos to Bob@rsr.org) - hundreds of stalactites at Australia's zinc mine at Mt. Isa.   - and those beneath Melbourne's Shrine of Remembrance. * Most Human Mutations Arose in 200 Generations: From Adam until Real Science Radio, in only 200 generations! The journal Nature reports The Recent Origin of Most Human Protein-coding Variants. As summarized by geneticist co-author Joshua Akey, "Most of the mutations that we found arose in the last 200 generations or so" (the same number previously published by biblical creationists). Another 2012 paper, in the American Journal of Physical Anthropology (Eugenie Scott's own field) on High mitochondrial mutation rates, shows that one mitochondrial DNA mutation occurs every other generation, which, as creationists point out, indicates that mtEve would have lived about 200 generations ago. That's not so old! * National Geographic's Not-So-Old Hard-Rock Canyon at Mount St. Helens: As our List of Not So Old Things (this web page) reveals, by a kneejerk reaction evolutionary scientists assign ages of tens or hundreds of thousands of years (or at least just long enough to contradict Moses' chronology in Genesis.) However, with closer study, routinely, more and more old ages get revised downward to fit the world's growing scientific knowledge. So the trend is not that more information lengthens ages, but rather, as data replaces guesswork, ages tend to shrink until they are consistent with the young-earth biblical timeframe. Consistent with this observation, the May 2000 issue of National Geographic quotes the U.S. Forest Service's scientist at Mount St. Helens, Peter Frenzen, describing the canyon on the north side of the volcano. "You'd expect a hard-rock canyon to be thousands, even hundreds of thousands of years old. But this was cut in less than a decade." And as for the volcano itself, while again, the kneejerk reaction of old-earthers would be to claim that most geologic features are hundreds of thousands or millions of years old, the atheistic National Geographic magazine acknowledges from the evidence that Mount St. Helens, the volcanic mount, is only about 4,000 years old! See below and more at rsr.org/mount-st-helens. * Mount St. Helens Dome Ten Years Old not 1.7 Million: Geochron Laboratories of Cambridge, Mass., using potassium-argon and other radiometric techniques claims the rock sample they dated, from the volcano's dome, solidified somewhere between 340,000 and 2.8 million years ago. However photographic evidence and historical reports document the dome's formation during the 1980s, just ten years prior to the samples being collected. With the age of this rock known, radiometric dating therefore gets the age 99.99999% wrong. * Devils Hole Pupfish Isolated Not for 13,000 Years But for 100: Secular scientists default to knee-jerk, older-than-Bible-age dates. However, a tiny Mojave desert fish is having none of it. Rather than having been genetically isolated from other fish for 13,000 years (which would make this small school of fish older than the Earth itself), according to a paper in the journal Nature, actual measurements of mutation rates indicate that the genetic diversity of these Pupfish could have been generated in about 100 years, give or take a few. * Polystrates like Spines and Rare Schools of Fossilized Jellyfish: Previously, seven sedimentary layers in Wisconsin had been described as taking a million years to form. And because jellyfish have no skeleton, as Charles Darwin pointed out, it is rare to find them among fossils. But now, reported in the journal Geology, a school of jellyfish fossils have been found throughout those same seven layers. So, polystrate fossils that condense the time of strata deposition from eons to hours or months, include: - Jellyfish in central Wisconsin were not deposited and fossilized over a million years but during a single event quick enough to trap a whole school. (This fossil school, therefore, taken as a unit forms a polystrate fossil.) Examples are everywhere that falsify the claims of strata deposition over millions of years. - Countless trilobites buried in astounding three dimensionality around the world are meticulously recovered from limestone, much of which is claimed to have been deposited very slowly. Contrariwise, because these specimens were buried rapidly in quickly laid down sediments, they show no evidence of greater erosion on their upper parts as compared to their lower parts. - The delicacy of radiating spine polystrates, like tadpole and jellyfish fossils, especially clearly demonstrate the rapidity of such strata deposition. - A second school of jellyfish, even though they rarely fossilized, exists in another locale with jellyfish fossils in multiple layers, in Australia's Brockman Iron Formation, constraining there too the rate of strata deposition. By the way, jellyfish are an example of evolution's big squeeze. Like galaxies evolving too quickly, 

Listen in as Real Science Radio host Fred Williams and co-host Doug McBurney review and update some of Bob Enyart's legendary list of not so old things! From Darwin's Finches to opals forming in months to man's genetic diversity in 200 generations, to carbon 14 everywhere it's not supposed to be (including in diamonds and dinosaur bones!), scientific observations simply defy the claim that the earth is billions of years old. Real science demands the dismissal of the alleged million and billion year ages asserted by the ungodly and the foolish.   * Finches Adapt in 17 Years, Not 2.3 Million: Charles Darwin's finches are claimed to have taken 2,300,000 years to diversify from an initial species blown onto the Galapagos Islands. Yet individuals from a single finch species on a U.S. Bird Reservation in the Pacific were introduced to a group of small islands 300 miles away and in at most 17 years, like Darwin's finches, they had diversified their beaks, related muscles, and behavior to fill various ecological niches. Hear about this also at rsr.org/spetner.  * Finches Speciate in Two Generations vs Two Million Years for Darwin's Birds?  Darwin's finches on the Galapagos Islands are said to have diversified into 14 species over a period of two million years. But in 2017 the journal Science reported a newcomer to the Island which within two generations spawned a reproductively isolated new species. In another instance as documented by Lee Spetner, a hundred birds of the same finch species introduced to an island cluster a 1,000 kilometers from Galapagos diversified into species with the typical variations in beak sizes, etc. "If this diversification occurred in less than seventeen years," Dr. Spetner asks, "why did Darwin's Galapagos finches [as claimed by evolutionists] have to take two million years?" * Opals Can Form in "A Few Months" And Don't Need 100,000 Years: A leading authority on opals, Allan W. Eckert, observed that, "scientific papers and textbooks have told that the process of opal formation requires tens of thousands of years, perhaps hundreds of thousands... Not true." A 2011 peer-reviewed paper in a geology journal from Australia, where almost all the world's opal is found, reported on the: "new timetable for opal formation involving weeks to a few months and not the hundreds of thousands of years envisaged by the conventional weathering model." (And apparently, per a 2019 report from Entomology Today, opals can even form around insects!) More knowledgeable scientists resist the uncritical, group-think insistence on false super-slow formation rates (as also for manganese nodules, gold veins, stone, petroleum, canyons and gullies, and even guts, all below). Regarding opals, Darwinian bias led geologists to long ignore possible quick action, as from microbes, as a possible explanation for these mineraloids. For both in nature and in the lab, opals form rapidly, not even in 10,000 years, but in weeks. See this also from creationists by a geologist, a paleobiochemist, and a nuclear chemist. * Blue Eyes Originated Not So Long Ago: Not a million years ago, nor a hundred thousand years ago, but based on a peer-reviewed paper in Human Genetics, a press release at Science Daily reports that, "research shows that people with blue eyes have a single, common ancestor. A team at the University of Copenhagen have tracked down a genetic mutation which took place 6-10,000 years ago and is the cause of the eye color of all blue-eyed humans alive on the planet today." * Adding the Entire Universe to our List of Not So Old Things? Based on March 2019 findings from Hubble, Nobel laureate Adam Riess of the Space Telescope Science Institute and his co-authors in the Astrophysical Journal estimate that the universe is about a billion years younger than previously thought! Then in September 2019 in the journal Science, the age dropped precipitously to as low as 11.4 billion years! Of course, these measurements also further squeeze the canonical story of the big bang chronology with its many already existing problems including the insufficient time to "evolve" distant mature galaxies, galaxy clusters, superclusters, enormous black holes, filaments, bubbles, walls, and other superstructures. So, even though the latest estimates are still absurdly too old (Google: big bang predictions, and click on the #1 ranked article, or just go on over there to rsr.org/bb), regardless, we thought we'd plop the whole universe down on our List of Not So Old Things!   * After the Soft Tissue Discoveries, NOW Dino DNA: When a North Carolina State University paleontologist took the Tyrannosaurus Rex photos to the right of original biological material, that led to the 2016 discovery of dinosaur DNA, So far researchers have also recovered dinosaur blood vessels, collagen, osteocytes, hemoglobin, red blood cells, and various proteins. As of May 2018, twenty-six scientific journals, including Nature, Science, PNAS, PLoS One, Bone, and Journal of Vertebrate Paleontology, have confirmed the discovery of biomaterial fossils from many dinosaurs! Organisms including T. Rex, hadrosaur, titanosaur, triceratops, Lufengosaur, mosasaur, and Archaeopteryx, and many others dated, allegedly, even hundreds of millions of years old, have yielded their endogenous, still-soft biological material. See the web's most complete listing of 100+ journal papers (screenshot, left) announcing these discoveries at bflist.rsr.org and see it in layman's terms at rsr.org/soft. * Rapid Stalactites, Stalagmites, Etc.: A construction worker in 1954 left a lemonade bottle in one of Australia's famous Jenolan Caves. By 2011 it had been naturally transformed into a stalagmite (below, right). Increasing scientific knowledge is arguing for rapid cave formation (see below, Nat'l Park Service shrinks Carlsbad Caverns formation estimates from 260M years, to 10M, to 2M, to it "depends"). Likewise, examples are growing of rapid formations with typical chemical make-up (see bottle, left) of classic stalactites and stalagmites including: - in Nat'l Geo the Carlsbad Caverns stalagmite that rapidly covered a bat - the tunnel stalagmites at Tennessee's Raccoon Mountain - hundreds of stalactites beneath the Lincoln Memorial - those near Gladfelter Hall at Philadelphia's Temple University (send photos to Bob@rsr.org) - hundreds of stalactites at Australia's zinc mine at Mt. Isa.   - and those beneath Melbourne's Shrine of Remembrance. * Most Human Mutations Arose in 200 Generations: From Adam until Real Science Radio, in only 200 generations! The journal Nature reports The Recent Origin of Most Human Protein-coding Variants. As summarized by geneticist co-author Joshua Akey, "Most of the mutations that we found arose in the last 200 generations or so" (the same number previously published by biblical creationists). Another 2012 paper, in the American Journal of Physical Anthropology (Eugenie Scott's own field) on High mitochondrial mutation rates, shows that one mitochondrial DNA mutation occurs every other generation, which, as creationists point out, indicates that mtEve would have lived about 200 generations ago. That's not so old! * National Geographic's Not-So-Old Hard-Rock Canyon at Mount St. Helens: As our List of Not So Old Things (this web page) reveals, by a kneejerk reaction evolutionary scientists assign ages of tens or hundreds of thousands of years (or at least just long enough to contradict Moses' chronology in Genesis.) However, with closer study, routinely, more and more old ages get revised downward to fit the world's growing scientific knowledge. So the trend is not that more information lengthens ages, but rather, as data replaces guesswork, ages tend to shrink until they are consistent with the young-earth biblical timeframe. Consistent with this observation, the May 2000 issue of National Geographic quotes the U.S. Forest Service's scientist at Mount St. Helens, Peter Frenzen, describing the canyon on the north side of the volcano. "You'd expect a hard-rock canyon to be thousands, even hundreds of thousands of years old. But this was cut in less than a decade." And as for the volcano itself, while again, the kneejerk reaction of old-earthers would be to claim that most geologic features are hundreds of thousands or millions of years old, the atheistic National Geographic magazine acknowledges from the evidence that Mount St. Helens, the volcanic mount, is only about 4,000 years old! See below and more at rsr.org/mount-st-helens. * Mount St. Helens Dome Ten Years Old not 1.7 Million: Geochron Laboratories of Cambridge, Mass., using potassium-argon and other radiometric techniques claims the rock sample they dated, from the volcano's dome, solidified somewhere between 340,000 and 2.8 million years ago. However photographic evidence and historical reports document the dome's formation during the 1980s, just ten years prior to the samples being collected. With the age of this rock known, radiometric dating therefore gets the age 99.99999% wrong. * Devils Hole Pupfish Isolated Not for 13,000 Years But for 100: Secular scientists default to knee-jerk, older-than-Bible-age dates. However, a tiny Mojave desert fish is having none of it. Rather than having been genetically isolated from other fish for 13,000 years (which would make this small school of fish older than the Earth itself), according to a paper in the journal Nature, actual measurements of mutation rates indicate that the genetic diversity of these Pupfish could have been generated in about 100 years, give or take a few. * Polystrates like Spines and Rare Schools of Fossilized Jellyfish: Previously, seven sedimentary layers in Wisconsin had been described as taking a million years to form. And because jellyfish have no skeleton, as Charles Darwin pointed out, it is rare to find them among fossils. But now, reported in the journal Geology, a school of jellyfish fossils have been found throughout those same seven layers. So, polystrate fossils that condense the time of strata deposition from eons to hours or months, include: - Jellyfish in central Wisconsin were not deposited and fossilized over a million years but during a single event quick enough to trap a whole school. (This fossil school, therefore, taken as a unit forms a polystrate fossil.) Examples are everywhere that falsify the claims of strata deposition over millions of years. - Countless trilobites buried in astounding three dimensionality around the world are meticulously recovered from limestone, much of which is claimed to have been deposited very slowly. Contrariwise, because these specimens were buried rapidly in quickly laid down sediments, they show no evidence of greater erosion on their upper parts as compared to their lower parts. - The delicacy of radiating spine polystrates, like tadpole and jellyfish fossils, especially clearly demonstrate the rapidity of such strata deposition. - A second school of jellyfish, even though they rarely fossilized, exists in another locale with jellyfish fossils in multiple layers, in Australia's Brockman Iron Formation, constraining there too the rate of strata deposition. By the way, jellyfish are an example of evolution's big squeeze. Like galaxies e

Tube Screamers—whether you love them, hate them, or can't decide, their impact on the guitar world is undeniable. In this episode of Four On The Floor, we explore four unique Tube Screamer-style variants, each offering a fresh take on the classic sound with added versatility and tonal options. Your guitar will thank you. Hosted by Todd Novak with Tony Dudzik, Rob Chafe, and Bobby Withers   #guitarpodcast #electricguitar #pedaleffects #pedalfx #theguitarknobs #guitarknobs #guitarinterview #guitaramplifier #guitarpickups #guitarsetup #fuzz #overdrive #reverb #distortion #guitartips    Visit us at theguitarknobs.com Support our show on Patreon.com/theguitarknobs

It's a heated debate in the Star Wars toy collecting world: Variants or Fariants? Tonight, the Five Idiots Talking Toys crew goes LIVE to hash it out! We'll be exploring which action figure variations hold true collectible value and which are potentially being overhyped. From mold differences and plastic degradation to paint breakdown, factory errors, running changes, and COO/factory distinctions, we're leaving no stone unturned. Get ready for an honest and opinionated discussion! #ToyCommunity #VariantDiscussion #FakeOrReal #CollectingTips #PodcastShow

New ransomware group claims attack on US Telecom firm WideOpenWest NSA warned of vulnerabilities in Signal app a month before Houthi strike chat New ReaderUpdate malware variants target macOS users Huge thanks to our episode sponsor, ThreatLocker ThreatLocker® is a global leader in Zero Trust endpoint security, offering cybersecurity controls to protect businesses from zero-day attacks and ransomware. ThreatLocker operates with a default deny approach to reduce the attack surface and mitigate potential cyber vulnerabilities. To learn more and start your free trial, visit ThreatLocker.com.

In this short podcast, I count down 10 unusual variants of migraine which illustrate the challenging diversity of what is otherwise a common and well-recognised disease.

The biggest stories on the internet from March 20th, 2025.Timestamps:1:23 Emma Chamberlain film debut4:02 Billboard cracks down on album variants5:58 Shay Mitchell's Beis pop up scandalFind our podcast YouTube channel here: https://www.youtube.com/channel/UC18HclY7Tt5-1e3Z-MEP7Jg Subscribe to our weekly Substack: https://centennialworld.substack.com/ Follow us on Instagram: https://www.instagram.com/infinitescrollpodcast/ Follow Lauren on Instagram: https://www.instagram.com/laurenmeisner_/ 

durée : 00:05:08 - Avec sciences - par : Alexandre Morales - Une nouvelle étude publiée dans Science dévoile un nouveau type d'anticorps efficace sur tous les variants de SARS-CoV-2 étudiés par les auteurs.

44 views Premiered 4 hours ago FITT: Wins & Wiffs of the WeekSometimes, you win; sometimes, you wiff! Check out this week's #actionfigures Wins and Wiffs of the week! Wait till you see this awesome pickup of a vintage toy that is just not easy to find these days. Stay on the #toyhunt folks!

Variants are kinda like clones right? Who's to say the Variants didn't get Star Wars: Episode II - Attack of the Clones'ed? *Insert R2 Scream for comedic effect*Please leave us a 5 star review on your podcast platform, drop us a follow on the socials, consider joining the Patreon, & share with your friends & family! Thank you for listening & thank you for all the support! Links for all of our stuff can be found here: https://linktr.ee/VariantVendettaYou can find our good friend's Podcasts here:https://linktr.ee/anyonescomichttps://linktr.ee/goingmerrypod

In this episode, DuDs and Carl discuss all the warm and cold additions to Minecraft. Plus, is the Creaking just the exact opposite of an Enderman? Also, Mending Minecraft is back! Make sure you vote in this episode's poll on Spotify, YouTube, and Discord.Thank you to our Milk level Patrons: Aerington, aubni, FragileRock, Jronman, LOKIOLR, and The Meme Bug.(AD) Do you need a Minecraft server? BisectHosting is recommended by the Podcast Team for easy set-up, 24/7 support with fast response times, and a 3-day money-back guarantee. Interested? Get 25% off your first month of any gaming server at ⁠⁠⁠⁠https://bisecthosting.com/TWE⁠⁠ and use code TWE at checkout. New clients only.Discord: ⁠⁠https://discord.gg/gqnKyeZ⁠⁠Patreon: ⁠⁠⁠⁠https://patreon.com/thewitheringeffect⁠⁠Website: ⁠⁠⁠⁠http://thewitheringeffect.com/⁠⁠E-Mail: ⁠⁠podcast@thewitheringeffect.com⁠⁠X/Twitter: ⁠⁠⁠⁠https://twitter.com/WitheringEffect⁠⁠YouTube: ⁠⁠⁠⁠https://youtube.com/thewitheringeffect⁠⁠Instagram: ⁠⁠⁠⁠https://instagram.com/witheringeffect⁠⁠TikTok: ⁠https://tiktok.com/@witheringeffect⁠Show HostDuDs YouTube: ⁠⁠⁠⁠https://youtube.com/DuDs_vs⁠⁠DuDs X/Twitter: ⁠⁠⁠⁠https://twitter.com/DuDs_vs⁠⁠DuDs Twitch: ⁠⁠https://twitch.tv/DuDs_vs⁠⁠Show Host / Digital ProducerCarlRyds YouTube: ⁠⁠⁠⁠https://youtube.com/CarlRydsGaming⁠⁠CarlRyds X/Twitter: ⁠⁠⁠⁠https://twitter.com/CarlRyds⁠⁠CarlRyds Twitch: ⁠⁠https://twitch.tv/CarlRydsGaming⁠⁠Music MasterDiiKoj YouTube: ⁠⁠⁠⁠https://youtube.com/DiiKoj⁠⁠DiiKoj X/Twitter: ⁠⁠⁠⁠https://twitter.com/DiiKoj

Summer Colling and Emma Wille speak with Datamonitor Healthcare's infectious disease analysts Charlotte Holmes and Natasha Boliter to discuss the latest trends in COVID-19 and influenza, including their global impact, vaccine developments, and the challenges in prevention. The experts break down the science behind these viruses, the future of combination vaccines, and what's next for respiratory disease prevention.

FINALLY. The Match (승부) will see the light of day! I'm so hyped. I do a full recap of the long road that this baduk film has traveled to get here, adding a brief thought on feeding your passion for Go. I also had lots of fun reading about all your Go variants!The Match Trailer (Eng Sub)Cards GoQuantum Go Video TutorialQuantum Go Rules---⁠Support Star Point⁠The Star Point Store

This Week on The Casual Hour…On this Deep Dive™ we talk about our favorite Video Game Console variations! From the 90's transparent tech love to those glow in the dark relics of the past, we are here to celebrate the weird and wonderful variations of the consoles we love. We still manage to check in on Kingdom Come: Deliverance II and Digimon? All that and more on this edition of The Casual Hour!// T W I T C H------------------------------------------------------------------------------------M W F @ 9 PM CSTtwitch.tv/thecasualhouryoutube.com/thecasualhourinstagram.com/thecasualhour// S U B S C R I B E------------------------------------------------------------------------------------https://www.youtube.com/thecasualhourWe post Quick Looks and VOD from previous streams weekly!// F O L L O W------------------------------------------------------------------------------------One link to rule them all: www.thecasualhour.com// T H E   C A S U A L   H O U R------------------------------------------------------------------------------------Bobby Pease - https://linktr.ee/bob_ombyChase Koeneke - http://Linktr.ee/chase_koeneke// M U S I C------------------------------------------------------------------------------------Love our theme music? It was created by Patric Brown. You can follow his antics on Twitter @insaneanalog or check out more of his music and download our theme at www.insaneanalog.com

Go with no vision and Go on a cube,Ever play Toroidal Go on a tube?⁠Support Star Point⁠The Star Point Store

Are you ready to live the life you deserve? Welcome to Victory.. Join the Variants in the season 2 premier, as we try to break free from the thrilling mystery the unfolds in this movie!Please leave us a 5 star review on your podcast platform, drop us a follow on the socials, consider joining the Patreon, & share with your friends & family! Thank you for listening & thank you for all the support! Links for all of our stuff can be found here:https://linktr.ee/VariantVendetta

Between 5-10% of breast and 20-25% of ovarian cancers are inherited. The majority of hereditary breast and ovarian cancer cases are caused by deleterious mutations (variants) in the BRCA1 and BRCA2 genes, which normally prevent cancer through protecting and repairing our DNA. Genetic testing is used to identify pathogenic BRCA carriers who would subsequently benefit from personalized screening, preventative and management plans. However, its widespread implementation has resulted in a significant increase in findings of variants of uncertain significance (VUS) – DNA sequence variants with uncertain effects on disease risk. VUSs pose a critical clinical challenge as they limit clinicians' ability to effectively interpret genetic test results. For upcoming interviews check out the Grad Chat webpage on Queen’s University School of Graduate Studies & Postdoctoral Affairs website.

In episode 2 of 'What's in a name' we look how choosing names can help, or hinder, attempts to communicate important messages.Categorizing things is central to science. And there are dozens of systems scientists have created to name everything from the trenches on the sea bed to the stars in the sky.But names have consequences. In our series What's in a name we explore naming in science and how names impact the world — whether the system of naming species remains in step with society, how the names of diseases can create stigma, or even how the names of scientific concepts can drive the direction of research itself.In episode two, we're looking at how the names chosen by scientists help, or hinder, communication with the public.Well chosen names can quickly convey scientific concepts or health messages — in emergency situations they can even save lives. We'll hear how the systems of naming tropical storms and Covid-19 variants came to be, and how they took different approaches to achieve the same outcome.We'll also consider the language used to talk about climate change, and how the ways of describing it have been used to deliberately introduce uncertainty and confusion.Listen to the first episode Should offensive species names be changed? The organisms that honour dictators, racists and criminalsFor a list of sources please visithttps://www.nature.com/articles/d41586-024-04200-9Music creditsPremiumaudio/Pond5Richard Smithson/Triple Scoop Music/Getty Images Hosted on Acast. See acast.com/privacy for more information.

Send us a textAuthor and journalist, Matt Haines explains how King Cake is more than just a dessert; it's a cultural celebration that blends history, tradition, and culinary artistry, especially during Mardi Gras. The episode explores the origins, varieties, and the community rituals surrounding King Cake, highlighting its significance in New Orleans' seasonal festivities. Plus, chef Sara Salgado bakes up fresh King Cake right in studio! • Overview of Mardi Gras and King Cake season • Historical origins linking King Cake to ancient Roman celebrations • The evolution of King Cake in New Orleans culture • Variants and unique flavors that reflect local creativity • Social rituals and etiquette surrounding King Cake consumption • Importance of King Cakes in supporting local bakeries and economies • Advice for experiencing King Cake for the first time • Insights from guests about the future of King Cake traditionsIntroducing the SupraCut System - the automated solution that enhances safety, quality, and efficiency, cutting up to 120 perfect citrus wedges per minute, 6 times faster than manual. Patented tech delivers uniform slices, reducing waste and eliminating plastic, while the hygienic, contactless design lowers contamination and injuries, integrating seamlessly to transform your operations and improve profitability - get started at SupraCut.com and ask about risk-free trials. Elevate your dining experience with RAK Porcelain USA! As the exclusive tableware brand for the Walk-In Talk Podcast, RAK combines exceptional craftsmanship with innovative design. Whether you're a chef, a restaurant owner, or a food enthusiast, RAK's high-quality porcelain products will enhance every meal. Discover the artistry of food presentation and make every dining occasion special. Visit rakporcelain.com today and see how RAK can transform your table The following brands and companies help us continue supporting the food industry - have a look below! Support the showThank you for listening to the Walk-In Talk Podcast, hosted by Carl Fiadini and Company. Our show not only explores the exciting and chaotic world of the restaurant business and amazing eateries but also advocates for mental health awareness in the food industry. Our podcast offers a behind-the-scenes look at the industry. Don't miss out on upcoming episodes where we'll continue to cook up thought-provoking discussions on important topics, including mental health awareness.Be sure to visit our website for more food industry-related content, including our very own TV show called Restaurant Recipes where we feature Chefs cooking up their dishes and also The Dirty Dash Cocktail Hour; the focus is mixology and amazing drinks!Thank you for tuning in, and we'll catch you next time on the Walk-In Talk Podcast. https://www.TheWalkInTalk.comLeave a review and rating, please!

In this episode, Martin Witzenrath, MD, FERS, and Michele Bartoletti, MD, PhD, discuss the management of mild to moderate COVID-19 in patients who are immunocompromised, including:Initial workup, which may include laboratory tests and/or imagingLatest data on the use of remdesivir or nirmatrelvir plus ritonavir for mild to moderate COVID-19, including considerations for drug–drug interactions Presenters:Martin Witzenrath, MD, FERSMedical DirectorCharite Centrum 12Internal Medicine & DermatologyProfessor and Chair for Respiratory Medicine and Critical CareDepartment of Infectious Disease, Respiratory Medicine and Critical CareCharite Campus Mitte/Campus Virchow Klinikum/Campus Benjamin FranklinCharite – University of BerlinBerlin, GermanyMichele Bartoletti, MD, PhDAssociate Professor of Infectious DiseasesDepartment of Biomedical SciencesHumanitas UniversityPieve Emanuele (MI), ItalyHead of Infectious Diseases UnitIRCCS Humanitas Research HospitalRozzano (MI), Italy Link to full program: https://bit.ly/4gu2gcUDownloadable slides: https://bit.ly/3CGlDBSGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

In this episode of Bladder Cancer Matters, host Rick Bangs is joined by the esteemed Dr. Ashish Kamat of MD Anderson Cancer Center to dive into the often-overlooked world of histologic subtypes, or variants, of bladder cancer. These rare subtypes can significantly alter how bladder cancer behaves and responds to treatment. Dr. Kamat breaks down the science behind these variants in a way that's both accessible and empowering for patients, offering crucial insights into why understanding your specific diagnosis matters. From the differences between common urothelial cancer and variants to the critical questions patients should ask their doctors, this conversation is packed with valuable information for anyone navigating a bladder cancer journey.

William H. Sauer, MD, FHRS, CCDS, Brigham and Women's Hospital is joined by Ezim Ajufo, MD, Brigham and Women's Hospital and Victor Nauffal, MD, Brigham and Women's Hospital to discuss the Patients with rare, pathogenic cardiomyopathy (CM) and arrhythmia variants that can present with atrial fibrillation (AF). The efficacy of AF ablation in these patients is unknown. This study tested the hypotheses that: 1) patients with a pathogenic variant in any CM or arrhythmia gene have increased recurrence following AF ablation; and 2) patients with a pathogenic variant associated with a specific gene group (arrhythmogenic left ventricular CM [ALVC], arrhythmogenic right ventricular CM, dilated CM, hypertrophic CM, or a channelopathy) have increased recurrence.  https://www.hrsonline.org/education/TheLead https://doi.org/10.1016/j.jacep.2024.06.035 Host Disclosure(s): W. Sauer: Honoraria/Speaking/Consulting: Biotronik, Biosense Webster, Inc., Abbott, Boston Scientific, Research: Medtronic   Contributor Disclosure(s): E. Ajufo: Nothing to disclose. V. Nauffal: Nothing to disclose.

In this episode, I sit down with Natalie Richheimer, a genetic counselor at JScreen, to dig into the world of preconception and prenatal genetic testing. We explore the basics of carrier screening, how to interpret results, and the importance of genetic counseling for both new and experienced parents—especially those who already have a child with a rare disease. Natalie also sheds light on Variants of Uncertain Significance (VUS) and offers insight into talking with family members about genetic risks and results. Throughout our chat, Natalie emphasizes that knowledge truly is power when it comes to family planning and navigating the complexities of genetic information. We discuss strategies for deciding between natural pregnancy, IVF with genetic screening, and other alternatives, helping you feel more confident and informed about your options. Whether you're just beginning your journey or seeking clarity in the midst of it, this episode offers valuable perspectives and heartfelt advice. Join us as we learn how to take charge of our genetic health and family-planning decisions with compassion and confidence. Finally, don't forget about the Once Upon a Gene Revival—an uplifting event designed to support, educate, and connect rare disease caregivers. Registration is open now on my website. Links: JScreen Genetic Testing Instagram Once Upon A Gene Revival

Jump in with Carlos Juico and Gavin Ruta on episode 217 of Jumpers Jump. This episode we discuss: LA Fire theories, Dark Hollywood theories, Alien Ocean theory, Project Blue Beam, Universe theories, Multiverse Jumping theory, The Upside Down is Real, Dark Nemo theory, The Losses before the Wins, Rarest Blood Type theory, Annunaki theories, Sabrina Priest Scandal, Supply & Demand theory, Community Subconscious theory, Square reality theory, Dog poop mandela effect, Burnt toast theory, The Chinese Farmer story, Fate theories, Carlos 22 Variants, Artist theories, Social Media theory, The Meaning of Life, Sentimental Value and much more! Download the DraftKings Sportsbook app and use code JUMPERSJUMP. That's code JUMPERSJUMP for new customers to get $200 in bonus bets instantly, when you bet just five bucks. Only on DraftKings Sportsbook - The Crown Is Yours. Gambling problem? Call one eight hundred Gambler. In New York, call 8778 HOPENY or text HOPENY (467369). In Connecticut, Help is available for problem gambling. Call 8887897777 or visit ccpg.org. Please play responsibly. On behalf of Boot Hill Casino & Resort (Kansas). Twenty-one plus age and eligibility varies by jurisdiction. Void in Ontario. Bonus bets expire one hundred sixty eight hours after issuance. For additional terms and responsible gaming resources, see DKNG.CO/AUDIO. Follow the podcast: @JumpersPodcast Follow Carlos: @CarlosJuico Follow Gavin: @GavinRutaa Check out the podcast on YouTube: https://bit.ly/JumpersJumpYT Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week on The Genetics Podcast, we're joined by Hilary Martin, Group Leader in Human Genetics at the world-renowned Wellcome Sanger Institute. Hilary and Patrick discuss her group's work on neurodevelopmental conditions, the role of common genetic variants in rare disease, and how to untangle the impact of direct and indirect genetic influences on various traits. Find out more Nature paper: Examining the role of common variants in rare neurodevelopmental conditions https://www.nature.com/articles/s41586-024-08217-y Genes and Health Project https://www.genesandhealth.org

We're thrilled to share a special episode drop from one of our producers, Kira Dineen, and her flagship podcast, DNA Today! As a multi award winning genetics podcast with over 12 years of groundbreaking episodes, DNA Today explores the latest in genetics and genomics through expert interviews and engaging discussions.    To celebrate the new year, this episode reflects back on the top genetics and genomics news stories during 2024. The top stories we chatted about are from the American Journal of Human Genetics' “Genomic medicine year in review: 2024” paper.    Joining Kira Dineen for this discussion are two leaders in genomics: Dr. Bruce Gelb and Dr. Eric Green. In this reflective conversation, Kira Dineen, Dr. Bruce Gelb, and Dr. Eric Green discusses the significant developments in genetics and genomics over the past year, including the recent American Society of Human Genetics (ASHG) conference. They explore themes such as variable expressivity, the integration of genomics in human genetics, and the importance of diversity in genomic research.    The discussion also highlights key publications in genomic medicine and the evolving landscape of genetic research, emphasizing the need for continued focus on prevention and the implications of polygenic risk scores. They converse about the evolving landscape of genomic medicine, highlighting key advancements in research, particularly in areas like hemochromatosis and CRISPR technology. They reflect on the rapid progress made in genomic sequencing, especially in newborns, and the transformative impact it has on healthcare, particularly in NICUs. The discussion emphasizes the importance of diverse studies and scalable solutions in genetic counseling, as well as the future potential of genomic medicine to save lives and improve health outcomes.    Top 2024 Genomic Medicine Advancements Testing and managing iron overload after genetic screening-identified hemochromatosis Actionable genotypes and their association with lifespan in Iceland Impact of digitally enhanced genetic results disclosure in diverse families Chronic disease polygenic risk scores for clinical implementation in diverse US populations Skeletal Muscle Ryanodine Receptor 1 Variants and Malignant Hyperthermia Treating inherited retinal disease with gene-editing Validation of a clinical breast cancer risk assessment tool for all ancestries Broader access to clinical genome sequencing benefits diverse individuals with rare diseases Benefits for children with suspected cancer from routine whole-genome sequencing Clinical signatures of genetic epilepsies precede diagnosis in electronic medical records   The Guests:    Bruce D. Gelb, M.D. is the Director and Gogel Family Professor of the Mindich Child Health and Development Institute at the Icahn School of Medicine at Mount Sinai. He is Professor of Pediatrics and of Genetics and Genomic Sciences. Dr. Gelb completed a pediatric residency and pediatric cardiology fellowship at Babies Hospital of Columbia-Presbyterian Medical Center and Texas Children's Hospital at the Baylor College of Medicine, respectively. He joined the faculty at Mount Sinai in 1991 after fellowship and has remained there since. He developed and now oversees an extensive program in genomics/gene discovery for congenital heart disease. Dr. Gelb has received the E. Mead Johnson Award from the Society for Pediatric Research and the Norman J. Siegel New Member Outstanding Science Award from the American Pediatric Society. He was elected to the American Society of Clinical Investigation and the National Academy of Medicine (formerly, the Institute of Medicine). Dr. Gelb is the President for the American Pediatric Society, Immediate Past President for the International Pediatric Research Foundation and Treasurer-Elect for the American Society of Human Genetics. In addition to his research, he co-directs the Cardiovascular Genetics Program at Mount Sinai.   Dr. Eric Green is the director of the National Human Genome Research Institute (NHGRI) at the U.S. National Institutes of Health (NIH). As NHGRI director, Dr. Green leads the Institute's research programs and other initiatives. He has played an instrumental leadership role in developing many high-profile efforts relevant to genomics. Dr. Green received his B.S. degree in bacteriology from the University of Wisconsin - Madison in 1981, and his M.D. and Ph.D. degrees from Washington University in 1987. Coincidentally, 1987 was the same year that the word “genomics” was coined. Dr. Green's relationship with the Institute began long before his appointment as director. He served as the Institute's scientific director (2002 - 2009), chief of the NHGRI Genome Technology Branch (1996 - 2009) and founding director of the NIH Intramural Sequencing Center (1997 - 2009). Prior to that, he played an integral role in the Human Genome Project. Dr. Green is a founding editor of the journal Genome Research (1995 - present) and a series editor of Genome Analysis: A Laboratory Manual (1994 - 1998), both published by Cold Spring Harbor Laboratory Press. He is also co-editor of Annual Review of Genomics and Human Genetics (since 2005). Throughout his career, he has authored and co-authored over 385 scientific publications.    Dr. Green is a recurring guest on DNA Today, and he might hold the title as the guest who has been on the show the most times! He was featured on Episode #182 when we chatted about the Human Genome Project and the recent completion of the human genome sequence -- from telomere to telomere. Dr. Green was a panelist on the PhenoTips Speaker Series installment that our host Kira Dineen moderated about population genomics in clinical practice, this was also released on the DNA Today podcast feed as Episode #260. He was also on the last couple years for our genetics wrapped 2022 (#214) and 2023 (#263).    Be sure to subscribe to DNA Today wherever you get your podcasts to explore hundreds of episodes on topics ranging from genetic counseling to cutting-edge research in genomics. New episodes are released every Friday. In the meantime, you can binge over 300 other episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Today”. Episodes since 2021 are also recorded with video which you can watch on our YouTube channel, this includes some episodes recorded at NBC Universal Stamford Studios.    DNA Today is hosted and produced by Kira Dineen. Our video lead is Amanda Andreoli. Our social media lead is Kajal Patel. Our Outreach Intern is Liv Davidson. And our logo Graphic Designer is Ashlyn Enokian, MS, CGC.    See what else we are up to on Instagram, X (Twitter), Threads, LinkedIn, Facebook, YouTube and our website, DNAToday.com. Questions/inquiries can be sent to info@DNAtoday.com. 

Hosts: Ed Gallagher and Brad McNutt  |  Released Wednesday, January 1, 2025 Watch the Video: [Coming Soon!] We want to hear from you! Subscription Links  

Today, we’re going to talk to Carmen David, who is going to share her experience with an aortic dissection after the delivery of her second daughter, her experiences recovering from that physically and emotionally, how she handled the information of two VUS’s, or Variants of Unknown Significance, and what she’s been doing since her dissection … Read More Read More

In this episode I discuss the following: The DJ Spin with my Christmas

Steve Mason - People To The River! (Warmduscher Remix) Joe Goddard - Revery (feat. Alabaster DePlume) Overmono feat. Ruthven - Gem Lingo (ovr now) Caribou - Come Find Me Moscoman & COMA - Ride Heiko Voss - Follow your line (Michael Mayer Dub Mix) Cold Cave - Hourglass Curses - Get Lost Skelesys feat. Curses - Pictures In My Mind Museum Of Love - After Us Max Richter - The Poetry of Earth (Geophony) Vanity Fairy - Top of the Pops (Sworn Virgins Remix) Gui Boratto,Darren Emerson - The Shell Warmduscher - Top Shelf Saint Etienne - Half Light

Nick Da Greek Geek and Snap Decisions join forces to preview the newest patch and the datamines that accompanied it including the Brave New World February season and more! 00:00:00 Intro00:00:36 February Season Pass00:03:00 New Card Backs00:05:38 January and February Spotlights00:27:37 Datamined Effects00:31:01 Character Mastery00:34:24 Variants00:55:31 Upcoming, Dated Variant Releases00:56:53 Upcoming Albums

Scott and Wes break down the tech behind video streaming for the web, from transcoding and variants to CDN and access control. They also share insights on tools like Mux, Cloudflare Stream, and ffmpeg, plus tips for managing bandwidth, hosting, and costs. Show Notes 00:00 Welcome to Syntax! 00:50 Brought to you by Sentry.io. 01:15 The history of video streaming. 02:10 How video streaming works: The Tech. 03:54 How video streaming works: Transcoding. 06:37 How video streaming works: Variants. ffmpeg. Wes' R2-video-streaming. Wes' Transcoding. YT-DL. YT-DLP. 13:13 Dynamic ad insertion. 14:29 Bandwidth and hosting. Mux. 18:03 Cloudflare. 19:13 The costs. Wes Bos Tweet Cloudflare TOS. Steve Tenuto tweet. 25:39 Media players. Media Chrome. 29:42 CDN. 32:04 Access control. 33:35 Solutions. Mux. Cloudflare Stream. Bunny.net Stream AWS Media Convert. Cloudinary. Bitmovin. 41:55 Some other features. 45:47 Sick Picks & Shameless Plugs. Sick Picks Scott: Anker MagGo. Wes: PolyCapture. Shameless Plugs Scott: Syntax on YouTube. Hit us up on Socials! Syntax: X Instagram Tiktok LinkedIn Threads Wes: X Instagram Tiktok LinkedIn Threads Scott: X Instagram Tiktok LinkedIn Threads Randy: X Instagram YouTube Threads

In the realm of nutrition science, individual differences are more profound and impactful than many realize. For decades, we've developed dietary recommendations with a “one-size-fits-all” approach, assuming that most people respond similarly to specific nutrients. But Dr. Martin Kohlmeier, a pioneer in precision nutrition, challenges this very notion. How might an individual's genetic makeup alter their need for certain nutrients? With advances in nutrigenetics, we're beginning to see how personalized nutrition could bridge long-standing gaps in dietary efficacy. Dr. Kohlmeier's work highlights fascinating examples, from the APOE4 gene's influence on cholesterol metabolism to variations in folate metabolism that could affect everything from heart health to birth outcomes. As Dr. Kohlmeier explains, precision nutrition is not simply about adding genetic testing to a wellness regimen. Instead, it requires rethinking nutrition research from the ground up—ensuring studies capture these individual variations and that public health policy moves beyond broad averages. With genetic testing now more accessible than ever, could commercial pressures and oversimplified testing derail the science before it even gets going? In this episode, we dive deep into the potential and pitfalls of precision nutrition, exploring the future of personalized dietary advice and the road to truly individualized health. Timestamps [02:33] Introduction of Dr. Martin Kohlmeier and his background [05:10] Rethinking assumptions in nutrition science [07:42] The role of genetic variations in nutrient responses [13:15] Practical examples of genetic impact on nutrition [22:55] Misinformation and commercial misuse in nutrigenetics [29:48] Case studies: cholesterol sensitivity (APOE4) and folate metabolism (MTHFR) [41:03] Public health implications and the need for tailored research [49:27] Future directions and the path forward for precision nutrition Links Go to episode page Join the Sigma email newsletter for free Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course Kohlmeier, 2023 – One size does not fit all: on the need for categorical stratification in nutrition science, practice and policy

Tony opens the show by talking about buying some candy and also about his adventures walking on the boardwalk in Rehoboth Beach. Kenny McPeek - the trainer of the Kentucky Derby winning horse Mystik Dan - calls in to talk about how winning the Derby has impacted his life, and also about a filly he has running in the Travers Stakes this weekend, gambling expert Jeff Ma calls in to talk about futures bets and also about fantasy football strategies, and Tony closes out the show by opening up the Mailbag. Songs : Interstate Rivals “What's It About” ; “Skazzarella Stix” To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices