Podcasts about variants

For the latest Whisper in the Wings from Stage Whisper, we are thrilled to be continuing our coverage of the Great Salt Lake Fringe Festival. And this time around, we welcomed on four shows and the artists behind them. So be sure you tune in and turn out to support these fantastic works!The Great Salt Lake Fringe FestivalJuly 23rd- August 2nd@ Alliance Theatre, MadKing Fellowship Theater, and Lightree StudiosTickets and more information are available at greatsaltlakefringe.org And be sure to follow our guests to stay up to date on all their upcoming projects and productions: The Variants written/produced by Randall Huskinson July 25th-August 2nd@ Alliance Theatrethevariantsplay.comReplacements created/directed by AB Harrison July 25th-August 2nd@ Alliance Theatre@saltmonstertheatrecoab@abharrison.comThis is Jane written by Kendra Preston Leonard July 24th-August 2nd@ MadKing's Fellowship Theateroperacontempo.comkendraprestonleonard.comSugar Mud created/performed by Maggie Beasley July 25th-August 2nd@ Alliance Theatre@meat_bar

Dr. Derek Stitt and Dr. Jennifer Morganroth discuss why identifying carrier status is so important.  Show citation:  Morganroth J, Yasek J, Harms M. Preparing Amyotrophic Lateral Sclerosis Clinics to Provide Longitudinal Care for Individuals Carrying ALS Risk Variants. Neurol Genet. 2026;12(4):e200406. Published 2026 Jun 24. doi:10.1212/NXG.0000000000200406  

Dr. Derek Stitt talks with Dr. Jennifer Morganroth about the evolving landscape of genetic testing in ALS, the importance of longitudinal care for at-risk individuals, and the capacity challenges faced by clinics.  Read the related article in Neurology® Genetics.  Disclosures can be found at Neurology.org. 

fWotD Episode 3359: Holden Commodore (VE) Welcome to featured Wiki of the Day, your daily dose of knowledge from Wikipedia's finest articles.The featured article for Thursday, 16 July 2026, is Holden Commodore (VE).The Holden Commodore (VE) is a full-size car that was produced from 2006 to 2013 by Holden, the former Australian subsidiary of General Motors. Dubbed Holden's "billion dollar baby", the car was available as the Holden Berlina—the mid-range model—and the Holden Calais, the luxury variant; utility body styles were marketed as the Holden Ute.Succeeding the VZ series, the VE was the first iteration of the fourth generation of the Holden Commodore, a series of automobiles built between 1978 and 2020. Unlike its predecessors, which used Opel-sourced platforms adapted to mechanics and sizes that would suit the local market, the VE was the first Commodore entirely designed and developed by Holden in Australia. To minimise export redevelopment costs, features such as a symmetrical centre console housing a flush-fitting hand brake lever facilitated the conversion to left-hand drive. The VE was internationally badge-engineered as the Chevrolet Lumina, Chevrolet Omega, Bitter Vero Sport and Pontiac G8.Holden introduced the VE body styles in stages, beginning with the sedan in July 2006. Before this, the company stated they would manufacture two parallel generations of Commodores until the launch of the station wagon and utility. Variants by Holden's performance vehicle partner, Holden Special Vehicles, were released soon after the sedan's debut alongside the long-wheelbase WM Statesman/Caprice models. The VE Ute entered production in 2007, coinciding with the unveiling of the Sportwagon concept car. The production version of the VE Sportwagon—which shared its 2,915 mm (114.8 in) wheelbase with the sedan instead of the extended wheelbase from the Caprice, like previous models—was introduced in July 2008.Named the 2006 Car of the Year by Wheels, the VE frequently ranked as the annual best-selling automobile in Australia over its production run. Holden introduced updates to the VE as model year (MY) changes. Typically subtle, these recurring changes have involved alterations to colours and trim, increased standard equipment and reduced fuel consumption. More noteworthy adjustments have come in the form of a smaller 3.0-litre V6 engine for entry-level versions and "Series II" styling revisions in September 2010.This recording reflects the Wikipedia text as of 00:02 UTC on Thursday, 16 July 2026.For the full current version of the article, see Holden Commodore (VE) on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Mastodon at @wikioftheday@masto.ai.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm standard Matthew.

Matt and David take on another round of Buy or Sell! They debate whether brands should be creating multiple variants of the same shoe, adding specialty uppers to existing models, spinning off new lines from popular shoes, and making dramatic changes to long-standing favorites. They also weigh in on whether uppers matter more than midsoles before closing out with a couple bonus mailbag questions. Want your buy/sell proposition or mailbag question on the next episode? Email us at doctorsofrunning@gmail.com!Rabbit is the presenting partner of our podcast. You can use code SUMMERDOCS to get 10% off your entire order of $50.00 or more. Note that the code is limited to one use per customer and can't be combined with other discounts. The code is active from 1st of every month to last day at 11:59PM PST, but don't worry because we'll be bringing you a new code every month. Shop now at https://www.runinrabbit.com.Our In For Testing segment is fueled by Skratch Labs! Get 20% off your first order from Skratch with code: DOCTORSOFRUNNING! https://www.skratchlabs.comChapters0:00 - Intro3:50 - In for Testing: Powered by Skratch Labs21:50 - Buy or Sell: Making multiple variants of the same shoe28:18 - Specialty uppers on existing shoes33:15 - Uppers are more important than midsoles36:16 - Creating new shoe models out of popular shoe lines44:47 - Dramatically changing a long-standing shoe51:08 - Mailbag: what causes black toenails?56:14 - Racing shoes to help with SI joint pain1:06:22 - Wrap-up

On today's Good Day Health Show - ON DEMAND…Host Doug Stephan and Dr. Ken Kronhaus of Lake Cardiology (352-735-1400) cover a number of topics affecting our health. First up, Doug and Dr. Ken discuss the latest developments in medicine, technology, and preventive healthcare. The conversation explores how artificial intelligence is transforming medical diagnosis and disease prevention, allowing healthcare providers to identify health risks earlier and deliver more personalized patient care. Dr. Ken also examines advances in cardiovascular risk assessment, highlighting new tools and strategies that can help prevent heart disease before symptoms develop. The episode takes a closer look at the relationship between vaccinations and heart health, along with emerging research on neurogenesis and the brain's ability to adapt and form new neural connections throughout life. Dr. Ken discusses the importance of maintaining brain health as we age, including the benefits of treating hearing loss with hearing aids to support communication, cognitive function, and social engagement. Listeners will also hear updates on weight-loss strategies, including both prescription medications and natural supplement options, as well as a discussion of statins and alternative cholesterol-lowering therapies for cardiovascular protection.Rounding out the episode, Dr. Ken provides an update on current COVID-19 variants and vaccination strategies while emphasizing the importance of individualized healthcare decisions. Throughout the conversation, he highlights the everyday lifestyle choices—including nutrition, exercise, sleep, and social connection—that play a critical role in protecting brain health, reducing disease risk, and promoting healthy aging. Together, these topics offer listeners practical guidance and the latest medical insights for improving long-term health and wellness. For more on Good Day Health…Website: GoodDayHealthShow.comSocial Media: @GoodDayNetworks

Will and Craig discuss the latest releases by The Love Variants, Shapes Like People, and Office Dog, plus live reports, bonus songs, and the World Cup.

ABOUT THE EPISODEAre Islam and Christianity separated brothers, mortal enemies, or something in between? History tells the storySponsorThis month, we're talking about how Christians engage with Islam, a conversation Southern Seminary has taken seriously for a long time. As President Al Mohler has put it, you can't prepare a minister for today's world without reckoning with Islam. That conviction is why Southern now offers a PhD in Islamic Studies, and why it's home to the Jenkins Center, a team devoted to helping pastors, missionaries, and everyday believers reach their Muslim neighbors with the gospel. To find resources and learn more about degrees, visit sbts.edu/islamicstudies. And be sure to listen to our interview with Dr Ayman Ibrahim, who is the head of the Jenkins Center.Timestamps00:41 - Intro03:20 - Examining Muhammad's Role and Christian Rejection09:32 - Analyzing the Quran's Gnostic Connections and Distorted Narratives18:13 - Unpacking th Quran's Variants and Historical Inaccuracies26:33 - Understanding Abrogation and Muslim Migration to the West31:17 - Navigating Ministry Challenges with Muslim Migrants37:19 - Defining Terms and Learning about Islam for Gospel Outreach44:36 - Responding to Islam's Political Aims and Sharia Law56:27 - Asking the Crucial Question: Do You Have Assurance?Resources to Click“Islam and Christianity: A Brief History” – Tony Costa“Does the Bible Predict the Coming of Muhammad?” – Tony Costa“Jesus in Islam” – Tony Costa“Does the Qur'an Really Deny That Jesus was Crucified an Died on the Cross? Answer May Surprise You” – Tony Costa“Religious Diversity in France: Intergenerational Transmissions and Practices by Origins” – Lucas Drouhot“How Religious Groups' Sizes Changed in Europe, 2010-2020” – Conrad Hackett, et al.Sefaria Library Search Results for “Gabriel”Theme of the Month: Unmasking IslamGive to Support the WorkBooks to ReadEarly Christian Creeds & Hymns – Tony CostaThe Life of Muhammad – Muhammad Ibn IshāqThe History of Al-Tabari, Vol. 6: Muhammad at Mecca – W. Montgomery Watt & M.V. McDonaldTextual Criticism and Qur'an Manuscripts – Keith E. SmallQur'ans: Books of Divine Encounter – Keith E. SmallCorrections in Early Qur'an Manuscripts: Twenty Examples – Daniel Allen BrubakerQuran: The Final Testament: Authorized English VersionThe Sources of Islamic Law: The Islamic Theories of Abrogation – John BurtonThe Meaning of the Glorious Koran – Marmaduke PickthallThe Holy Quran: Translation by Abdullah Yusuf Ali – Abdullah Yusuf AliMuhammad is Not the Father of Any of Your Men: The Meaning of the Last Prophet – David S. PowersAnswering Islam: The Crescent in Light of the Cross – Norman L. Geisler and Abdul SaleebThe Integrity of the Bible according to the Qur'an and the Hadith – Ghiyathuddin Adelphi and Ernest HahnThe Decline of Eastern Christianity Under Islam: From Jihad to Dhimmitude: Seventh – Twentieth Century – Bat Ye'orBell's Introduction to the Qur'an – W. Montgomery and Richard BellThe Crucifixion and the Qur'an: A Study in the History of Muslim Thought – Todd LawsonThe End of the Journey: An Islamic Perspective on Death and the Afterlife – Abdullah Muhammad KhoujJesus Remembered: Christianity in the Making – James D.G. DunnThe Qur'an: Arabic Text and English Translation – M.H. Shakir

You may have heard people claim there are 200,000 to 400,000 Biblical "errors" in the New Testament, and a number that large can sound terrifying if you are trying to trust Scripture.But that claim is profoundly misleading. In this episode of the Binmin Popscast, we explain why serious scholars call these differences New Testament VARIANTS, not errors! Given the more than 5,800 handwritten Greek New Testament manuscripts, small differences are expected. But those differences do not mean the original text has been lost.Instead, the abundance of New Testament manuscripts gives scholars more material to compare. This helps them identify spelling differences, word order changes, accidental omissions, and other minor variations. Most variants are trivial and obvious, and even the genuinely debated ones do not change any core Christian doctrine.So when someone says there are hundreds of thousands of errors in the Bible, you do not need to panic. The better question is whether these variants destroy the reliability of the New Testament. The answer is no. Far from undermining confidence, the manuscript evidence shows that the New Testament has been preserved with remarkable care.The New Testament remains a trustworthy foundation for faith.SUBSCRIBE to our channel / @binmin_org JOIN the NEWSLETTER at https://binmin.org/newsletter/SUPPORT Binmin with a tax-deductible gift HERE - https://binmin.org/donateYouTube Clickable Chapters00:00 - ARE THERE ERRORS IN THE BIBLE?00:20 - WHERE DO THE BIG ERROR NUMBERS COME FROM?00:40 - VARIANTS, NOT ERRORS00:57 - A SIMPLE CLASSROOM EXAMPLE01:34 - NEW TESTAMENT MANUSCRIPTS EXPLAINED01:48 - INTENTIONAL AND UNINTENTIONAL VARIANTS02:09 - DO VARIANTS RUIN THE MESSAGE?02:20 - WHAT IS TEXTUAL CRITICISM?02:31 - MORE MANUSCRIPTS MEAN MORE EVIDENCE02:50 - THE 100-PIECE PUZZLE ANALOGY03:10 - MOST VARIANTS ARE MINOR03:28 - CORE CHRISTIAN BELIEFS ARE NOT CHANGED03:45 - WHY THE BIG NUMBER SHOULDN'T WORRY YOU04:07 - THE REMAINING 0.25%04:40 - PRESERVATION, NOT CORRUPTION05:07 - WHAT'S YOUR NEXT STEP?05:20 - LIKE, SUBSCRIBE, AND VISIT BINMINCONNECT WITH THE BINMIN TEAMTikTok: / binmin_orgInstagram: / binmin_orgFacebook: / binmindotorgLinkedIn: / binminAsk Questions: info@binmin.orgPODCAST RESOURCESExplore more from Binmin at Binmin.orgSubscribe on YouTube: https://tinyurl.com/Binmin-YoutubeSubscribe on Apple Podcasts: https://tinyurl.com/Binmin-apple-podcastFollow on Spotify: https://open.spotify.com/show/09etqAg...JOIN the NEWSLETTER at https://binmin.org/newsletter/Some Binmin videos are created with the contribution of AI tools and are always carefully reviewed, revised, and taught by our team to ensure they reflect our biblical convictions and theological clarity.#Christianity #BibleReliability #ErrorsInTheBible

As a holistic and functional psychiatrist, I see many people who are highly sensitive. Most are deep divers into information and able to connect a lot of dots. Many are gifted. Many struggle with overwhelm and low stress tolerance. Some struggled with anxiety, inner tension, or feeling “too much” for as long as they can remember. Some feel different - that they don't fit in.As a holistic and functional psychiatrist with over twenty years in practice, I've worked with thousands of highly sensitive adults and children. Most are deep divers into information, able to connect a lot of dots — many are gifted. And yet many struggle with overwhelm, low stress tolerance, anxiety, or inner tension that has been there for as long as they can remember. Many feel different, like they don't quite fit in. What I've found is that sensitivity itself is rarely the problem — it's the seeming vulnerability to brain-related or physical conditions. Over the years I've found three different models to be especially useful in explaining some of the vulnerabilities and the strengths of those of us who are highly sensitive: Dr. Elaine Aron's work on the Highly Sensitive Person (HSP), the nutritional medicine concept of Pyrrole Disorder, and Dr. Sharon Meglathery's RCCX Theory. Each looks at a similar group of traits through a different lens — psychological, biochemical, and genetic, respectively.Before I start, I want to emphasize that sensitivity is not a pathology or a diagnosis. It is actually a trait that has existed across human history for a reason. My goal is not to pathologize it, but to understand it — and to offer tools to those who have these traits but who are struggling with a condition more prevalent in those with these traits. As I go through these three frameworks, the overlap will be obvious and I'll highlight what each of these has to offer that the others don't.What You'll Learn* The HSP model provides validation and a language for sensitive individuals.* Pyrrole Disorder involves an overproduction of pyrroles, leading to nutrient depletion of nutrients critical for neurotransmitter functioning.* Pyrrole Disorder is common in brain-related conditions.* RCCX Theory connects genetic vulnerabilities to sensitivity and chronic illness.* Stress amplifies the experiences of highly sensitive individuals.* Understanding these models can lead to effective treatment options.* There are meaningful paths forward for those who are highly sensitive.Chapters* 00:00 Understanding High Sensitivity* 02:26 The Highly Sensitive Person (HSP) Model* 10:23 Exploring Pyrrole Disorder* 18:18 RCCX Theory Explained* 30:11 Intersecting Models: HSP, Pyrrole Disorder & RCCX Theory* 34:40 Conclusion and Path ForwardI. THE HIGHLY SENSITIVE PERSONIn the early 1990s, psychologist Dr. Elaine Aron identified a personality trait she called Sensory Processing Sensitivity (SPS) — and the people who score high in it she called Highly Sensitive Persons, or HSPs.This is not a diagnosis. It is a trait, present in roughly 15–20% of the population. It has been found across more than 100 species — from fruit flies to primates. This tells us it is evolutionarily conserved — it confers survival advantages. In any social group, having members who are wired to notice subtle cues, process information deeply, and detect threats before others do is extremely valuable. Fitting with this, many of these individuals, who also struggle with complex chronic health issues are considered the “canaries in the coal mine” since their bodies react to environmental triggers (environmental toxins, chemicals, or stressors) long before the rest of the population.Dr. Aron captured the core features of this trait in an acronym she called DOES:D — Depth of processing: HSPs think deeply, reflect before acting, and notice subtleties that others miss.O — Overstimulation: Because they process so thoroughly, HSPs reach their threshold more quickly in high-stimulation environments.E — Emotional reactivity and Empathy: HSPs feel emotions intensely and are highly attuned to the emotions of those around them.S — Sensitivity to subtle stimuli: They pick up on things — in their environment, in social dynamics, in the body — that others simply don't register.As you can see, traits that are super powers, can become liabilities. The deep diver who loses sight of the big picture. The empath who absorbs everyone else's energy as their own energy becomes depleted. The person who withdraws from the world because the stimulation has simply become too much.HSP ResearchBeyond the clinical observations, there is now a growing body of neuroscience and genetic research supporting this trait. There is evidence that the brains of sensitive people are doing more, processing more and feeling more.fMRI studies (Acevedo, Aron et al., 2014) have shown that when HSPs view emotional images — particularly photos of loved ones expressing happiness or sadness — their brains show significantly greater activation in regions associated with awareness, empathy, and sensory integration.Twin studies show that Sensory Processing Sensitivity (SPS) as defined by Dr. Aron is approximately 47% heritable. Small studies as opposed to large genome wide studies have focused on genetic variants involving dopamine and serotonin systems, such as a serotonin transport gene, a dopamine receptor gene, and COMT, which codes for the enzyme that metabolizes dopamine and norepinephrine.While this hints at a biochemical dimension, the HSP framework doesn't address this as directly as the other two models I'll discuss, nor does it explain the higher prevalence of physical health conditions in those who are highly sensitive.Research published in 2026 (Matsuzawa et al.) found that individuals high in SPS had substantially higher rates of depression (13.8%), anxiety disorder (10.5%), and developmental disorders, such as ADHD and ASD, compared to the general population.Despite this overlap with developmental disorders: unlike, ADHD, HSPs typically have excellent concentration in quiet environments. And unlike the social deficits described in ASD, HSPs tend to have heightened social attunement. They often feel too much of what's happening in social situations, not too little, even if they respond awkwardly at times.Research shows that high sensory processing sensitivity is associated with more frequent physical symptoms — back pain, fatigue, digestive issues, frequent illness.What This Framework OffersThe HSP model has given millions of people validation and a language for these traits that has allowed them to shift from “what is wrong with me” to “this is how I am wired.”It also offers an evolutionary reframe. High sensitivity is not a mistake and is not pathologic. It is a feature of the human population that has served us.What it doesn't offer is a biological explanation for why some sensitive people suffer so acutely — or a path toward biochemical intervention. II. PYRROLE DISORDERPyrrole disorder is a biochemical imbalance that has been recognized for decades, though it remains largely unknown in mainstream psychiatry. It involves an overproduction of pyrroles — metabolic byproducts that, on their own, are not a problem. When they are high, however, they can result in a depletion of zinc, B6 and a few other nutrients.First identified in the 1950s and first treated with zinc and B6 in the 1980s, pyrrole disorder is one of the most common nutrient imbalances found in brain-related conditions — and one of the most treatable. Yet most people who have it have never heard of it. I learned about pyrroles in 2014 when I first trained with the Walsh Research Institute.The Importance of Zinc, B6 & MagnesiumVitamin B6 is required to synthesize dopamine, serotonin, and GABA — three of the most critical neurotransmitters for mood regulation, anxiety, and stress response. Zinc plays a profound role in the central nervous system, the immune system, gastrointestinal tract (which we now know has its own significant influence on brain health) and connective tissue (joints and skin).Pyrrole Disorder Traits & SymptomsThe most consistent feature is low stress tolerance. People with elevated pyrroles are often described as those for whom life seems harder than it should be, every transition can be destabilizing and every large group or new environment feels like too much.The overlap with the HSP profile is striking, but here, we start to see not only traits, but symptoms.- Socially anxious, shy, or fearful since childhood, with severe inner tension- Sensitive to bright light, loud noises, textures, and odors- Avoids crowds, strangers, and new situations- History of reading difficulty- Poor short-term memory- Underachievement- Irritability, mood swings, bouts of depression- Tends to stay up late; little or no dream recall; morning nausea- White spots on fingernails; very dry skin; stretch marks; poor wound healing- Joint pain- Frequent infections or autoimmune tendenciesMost people with pyrrole disorder don't have all of these symptoms — but the inner tension, the high sensitivity, and low stress intolerance are very common.What the Data ShowsThe Walsh Research Institute has collected data on over 30,000 patients. Elevated pyrroles were found in:* 18% of those with ADHD* 24% of those with depression* 28% of those with behavioral disorders* 35% of those with autism* 35% of those with bipolar disorder* 30% of those with schizophrenia* 12% of those with PTSDAnd in only 8% of healthy controls — meaning those with no psychiatric diagnosis.What Causes Pyrrole Disorder?For many, there appears to be a genetic component, but for others, pyrroles appear to have increased due to high physiologic or emotional stress. Examples include candida overgrowth or other forms of gut microbial imbalances, mold toxicity, heavy metals, chemical exposures, illness, emotional trauma, major life transitions or even growth spurts in children.What This Framework Brings UsRelative to the HSP framework, an understanding of pyrroles gives a specific, treatable biological mechanism. When zinc, B6, Magnesium and other nutrients are depleted, we know how the brain's neurotransmitter functioning is affected — and we know what to do about it.Treatment from a Walsh Research Institute trained practitioner typically involves a nutrient protocol of zinc (based on zinc and copper testing), B6 or its active form P5P, and other nutrients for pyrrole disorder and other nutrient imbalances identified. For many patients, a lifetime of chronic inner tension and fearfulness begins to shift within days to a couple of weeks of starting the nutrients.Treatment doesn't change one's personality, but it can improve social discomfort, overwhelm, the anxiety, the depression that has been layered on top of that sensitivity.Where zinc deficiency can impact a lot of the physical conditions that appear to be more common in those who are hypersensitive, it doesn't fully explain the significant hormonal, inflammatory, connective tissue symptoms and autoimmunity we see in many who are hypersensitive.III. RCCX THEORYRCCX theory has been proposed by Dr. Sharon Meglathery, MD — a psychiatrist and internist whose own complex health history (which is very similar to my own) led her to one of the most compelling explanations I've encountered for why hypersensitivity, neurodivergence, psychiatric conditions, MCAS (Mast Cell Activation Syndrome), EDS (Ehlers Danlos Syndrome), POTS (Postural Orthostatic Tachycardia Syndrome), CIRS (Chronic Inflammatory Response Syndrome) and/or CFS (Chronic Fatigue Syndrome) and autoimmunity tend to cluster together in certain individuals and families.RCCX refers to a module of four genes on chromosome 6. Three of them appear to be particularly important to our health, and two of those have very high rates of mutation.The Three Key Genes(1) TNXB codes for a protein involved in connective tissue. Variants range from subtle joint hypermobility to Ehlers-Danlos Syndrome. But connective tissue isn't just about joints — it's also about the permeability of the gut-blood barrier, the blood-brain barrier, and vulnerability to upper cervical (neck) instability, which can put tension on the vagus nerve and affect the entire autonomic nervous system.(2) CYP21A2 is the most important gene in the module when it comes to psychiatric conditions. It codes for 21-hydroxylase, an enzyme needed to convert 17-hydroxyprogesterone into cortisol. When there is a mutation — and there can be many, of varying degrees — the body may struggle to meet the demand for cortisol under stress. A weakness on this gene could have two primary effects:First — The theory holds that many people with CYP21A2 mutations, even without hypermobility, may develop what Dr. Meglathery calls a “brain wired for danger” — essentially, a nervous system calibrated toward threat detection from early in life, with minimal trauma required. A mutation on CYP21A2 may essentially result in relatively higher androgens impacting the amygdala — the brain's fear and emotional center. Studies have found that hypermobile individuals (who often carry TNXB mutations) have a larger-than-normal amygdala.Second — because of this mutation, the body may not be able to keep up with the body's need for cortisol (especially when under stress). This deficit causes the brain to release corticotropin releasing hormone (CRH) to signal the adrenal glands to produce more cortisol. CRH binds to mast cells and activates the immune system — leading to secondary brain inflammation. This is the inflammatory pathway that can result in a number of secondary health issues including MCAS, CIRS, POTS, CFS and more.(3) C4 is involved in immune response and autoimmunity, and has been linked to schizophrenia. This gene variant is not as common as the first two referenced, though I do see a number of families who also have autoimmunity impacting multiple family members.The CAPS Psychological ProfileDr. Meglathery uses the term CAPS — CYP21A2 Mutation Associated Neuropsychiatric Spectrum — to describe the psychological profile she has observed in people with this genetic vulnerability. These traits can exist long before any formal psychiatric diagnosis, and they are not inherently pathological. - Anxiety and over-arousal during times of stress — high adrenaline, insomnia, sometimes manic-like characteristics- Under-arousal during low-stress periods — leading to ADD presentations, compulsive behaviors, or thrill-seeking to raise arousal- High emotionality, sensitivity, and reactivity to environmental stimuli- Sensory processing difficulties — typically over-stimulation in loud or chaotic environments- A strong ability to read emotions in others, paired with social awkwardness in response- Easily affected by events others would consider minor — an offhand comment, a disturbing movie- A tendency toward nonconformity- Special abilities: gifted musicians, scientists, creatives, systems thinkers- Hyper-focus and obsession with areas of deep interest, often leading to remarkable accomplishments- High tenacity and determination, when not derailed by overstimulation or past trauma- Strong emotions — positive or negative — that can manifest as obsessional worrying, harm avoidance, OCD tendencies, or very high standards for self and othersDr. Meglathery also notes — and I have observed this clinically — that people with this profile tend to find each other through friendships, partnerships and marriage. They are drawn together by shared sensitivities, emotional depth, and intellectual gifts. This means children are likely to receive a tendency towards CAPS from both sides.Women who are appear to have CYP21A2 mutations often have a male-pattern finger length ratio — the ring finger longer than the index finger — a possible marker of androgen exposure during development.What RCCX OffersRCCX theory offers the broadest biological framework we have for understanding why sensitivity, psychiatric vulnerability, and complex chronic illness so often travel together in the same people and families. It connects the nervous system, the immune system, the hormonal system, and connective tissue under one genetic umbrella.It also points toward specific interventions: nervous system regulation (limbic retraining, vagal work), mast cell management, and addressing the downstream biochemical consequences of cortisol dysregulation.The limitation is that genetic testing for variants on the gene for 21-hydroxylase is not yet widely available, which is why this isn't a gene that you'll see referenced when it comes to HSP, though I would argue it is likely the most prevalent. RCCX remains a clinical theory — but one that explains the constellation of traits and symptoms of most of the people that I in my practiceIV. WHERE THESE MODELS INTERSECTWhere Might Pyrrole Disorder and RCCX Theory Meet?The symptom overlap is almost complete: poor stress tolerance, sensory sensitivities, anxiety, inner tension, connective tissue symptoms, frequent infections, autoimmune tendencies. Relatively low zinc would impact most of these shared symptoms, but there may be a potentially deeper connection.21-hydroxylase contains a pyrrole-like structure — heme — within it. Could a mutation resulting in abnormal 21-hydroxylase lead to a buildup of abnormal heme-like compounds, contributing directly to pyrrole disorder? This is not proven, but in an exchange about this with Dr. Meglathery, she indicated that she also believes there is a strong association, and the biochemical logic is compelling.This matters, because we know what helps pyrrole disorder. We have a treatment — treatment that can complement what RCCX theory makes evident — that the stress response has to be addressed.Stress (again from any cause - physiologic or emotional) is the great amplifier across all three models. Stress worsens the HSP experience, and tips the CYP21A2 mutation from manageable to destabilizing (through the hormonal consequences and the inflammatory cascade) and yes, it even causes pyrroles to increase.BRINGING IT TOGETHERFor someone who is highly sensitive, and struggling with brain related or physical symptoms or conditions, pyrrole disorder and even RCCX theory are worth considering because they offer tools and start to answer, “What Can We Do About It?”The three frameworks work together:The HSP model offers validation and language. It shifts the frame from deficit to difference. It reminds us that sensitivity is not pathology — it is a trait with evolutionary value, and it comes with great strengths.The Pyrrole model offers a treatable nutrient imbalance. It explains, at the neurotransmitter level, why stress hits harder for these individuals. Treatment doesn't take away the sensitivity; it lifts the weight that has accumulated on top of it.The RCCX model offers the broadest systems view. It connects the dots between what the body is doing — the immune activation, the hormonal dysregulation, the connective tissue involvement — and the psychiatric and psychological profile that tends to accompany it. It also provides additional tools: nervous system regulation, mast cell support, hormonal awareness.If any of this resonates — the sensitivity, the inner tension, the feeling of always being at the edge of overwhelm — please know that there are roots to explore and meaningful paths forward.If you are looking for someone trained by the Walsh Research Institute knowledgeable in assessing for and treating pyrrole disorder (and other common nutrient imbalances impacting brain health), or learning more about Dr. Aron's work on HSP and Dr. Meglathery's RCCX theory, I am providing those links below.And as always, I welcome your thoughts, experience and questions.Until next time,CourtneyAbout the AuthorDr. Courtney Snyder MD is a Holistic and Functional Child and Adult Psychiatrist who offers non-patient consultations to individuals and practitioners nationally and internationally in addition to her treatment practice serving FL, IN, KY, OH. Her educational content, shared through her website, Substack Newsletter, the Holistic Psychiatry Podcast and YouTube Channel reaches readers and listeners in over 160 countries.ResourcesWalsh Research Institute: walshinstitute.orgRCCX Theory — Dr. Sharon Meglathery: rccxandillness.comDr. Elaine Aron — The Highly Sensitive Person: hsperson.comOther Sources: Acevedo et al. 2014, “The Highly Sensitive Brain,” Brain & Behavior | Matsuzawa et al. 2026, Psychiatry & Clinical Neurosciences ReportsMedical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

Marvel is collecting Dark Horse's Clone Wars comics. Daredevil gets Marvel TV variants. Where Monsters Lie gets an omnibus from Dark Horse.SUBSCRIBE ON RSS, APPLE, SPOTIFY, OR THE APP OF YOUR CHOICE. FOLLOW US ON BLUESKY, INSTAGRAM, TIKTOK, AND FACEBOOK. SUPPORT OUR SHOWS ON PATREON.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Ann M Moyer, Emma Lundquist, Emily K Thoreson, Michelle L Kluge, Katrina E Kotzer, Elyse M Love, Heather L Glessner, Sarah K Arneson, Loralie J Langman, Linnea M Baudhuin, John Logan Black. DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 662–669. https://doi.org/10.1093/clinchem/hvag007.

Exploring the Profound Understanding of Human Origin Variants  In the third chapter of the Esoteric Caravan journey, the exploration delves into the intricate tapestry of human origins, unraveling the mysteries of our diverse variants. This captivating odyssey merges ancient wisdom with modern insights, offering a unique perspective on the evolutionary and metaphysical threads that weave humanity together. From the whispers of forgotten civilizations to the revelations of cutting-edge research, each variant of human origin tells a story of adaptation, resilience, and transformation. The Inner-Standing approach invites a deeper connection, encouraging an experiential comprehension that transcends mere facts, guiding seekers toward an enlightened awareness of our shared yet varied heritage.

「「Wizardry Variants Daphne」伝説の冒険者「風哭嶺の怨霊 カゲロウ」（CV：山路和弘）が追加！新たな依頼や特別な支給品も」　ドリコムは、iOS/Android/PC（Steam）向けに配信中の「Wizardry Variants Daphne」において、本日6月11日に伝説の冒険者「風哭嶺の怨霊 カゲロウ」や新たな依頼などを追加した。

Your mood struggles might not be a mindset problem — they might be a methylation problem. In this episode, Nurse Doza breaks down the TMG supplement (trimethylglycine), how it drives serotonin and dopamine production, and why pairing it with SAMe in BLISS delivers clean energy and mood support — no caffeine, no stimulants, results in minutes. Featured Partner: MSW Nutrition — BLISS BLISS by MSW Nutrition combines two of the most underutilized mood-support compounds in functional medicine — trimethylglycine (TMG) and SAMe — in a fast-absorbing sublingual powder. Together, they fuel the methylation pathways your body needs to produce serotonin, dopamine, and sustainable energy — exactly the mechanisms Nurse Doza unpacks in this episode. No caffeine. No fillers. No stimulants. Just the two ingredients your brain chemistry has been waiting for.

In this episode, Dr. Paloma Giangrande, Editor-in-Chief of Molecular Therapy Nucleic Acids, speaks with Normand Allaire, Head of Genomics at the Cystic Fibrosis Foundation Therapeutics Lab. They discuss the article, Upregulation of a CFTR mRNA isoform has therapeutic potential for the treatment of 3’ CFTR PTC variants, which introduces an ASO-based therapeutic approach to cystic fibrosis for the 10% of patients who lack an approved treatment. Music: 'Electric Dreams' by Scott Buckley - released under CC-BY 4.0. www.scottbuckley.com.auShow your support for ASGCT!: https://asgct.org/membership/donateSee omnystudio.com/listener for privacy information.

Tulio De Oliveira explains the open public nomination process and says the award is symbolic rather than financial, coming with a medal whose first recipient was Nelson Mandela. He reflects on 30 years of outbreak work and stresses that early identification of pathogens and the development of diagnostics, therapies and vaccines save lives, especially in South Africa Webpage

Marlon Hue is a stand-up comedian & producer based in Chicago!

The audio for Chy is a bit choppy; I didn't want to scrap the whole thing so I did what I could in editing, and it gets better towards the end.Feedback : blackgirlcouch@gmail.com (audio/written)Tumblr: blackgirlcouchYoutube: ChristinaBCGInstagram: @blackgirlcouch

A groundbreaking genetic study reveals how specific DNA variants can alter how viruses like Epstein-Barr behave inside your cells, potentially affecting cancer risk. Researchers analyzed nearly fourteen thousand people to identify genetic changes that make some individuals more susceptible to nasopharyngeal carcinoma. Their findings show how genetics and viral infections work together in ways that could apply to other environmental stressors, including EMF exposure. In This Episode The largest genetic study of nasopharyngeal carcinoma to date How genetic variants can change viral behavior in cells Why this matters for understanding environmental health risks Featured Study Read the full study: Geng D, Liu A, Yan Y, Zheng W See all studies at shieldyourbody.com/research

In this new (not so new anymore) segment of PEM Rules Dr. Jay Fisher, who has been practicing PEM since 1992 came back to discuss an interesting case of something we don't see very often in the Peds ER and NEVER want to miss.   

Can you help me make more podcasts? Consider supporting me on Patreon as the service is 100% funded by you: https://EVne.ws/patreon You can read all the latest news on the blog here: https://EVne.ws/blog Subscribe for free and listen to the podcast on audio platforms:➤ Apple: https://EVne.ws/apple➤ YouTube Music: https://EVne.ws/youtubemusic➤ Spotify: https://EVne.ws/spotify➤ TuneIn: https://EVne.ws/tunein➤ iHeart: https://EVne.ws/iheart MERCEDES PREVIEWS ELECTRIC C-CLASS CABIN https://evne.ws/41Ar7XP MUSK COMPANIES PROPPED UP CYBERTRUCK Q4 https://evne.ws/4tL3pnu MAZDA6E UK PRICED FROM £38,995 https://evne.ws/3OoZeyY BMW ADDS CONTRACT-FREE PLUG & CHARGE IN GERMANY https://evne.ws/4tsBIAf BYD ADDS TWO SHARK 6 VARIANTS https://evne.ws/4mDGRTw ALLEGO ADDS SMART OVERNIGHT CHARGING IN DUTCH MARKET https://evne.ws/4cQ351b FUEL SPIKE PUSHES DRIVERS TOWARDS EVS https://evne.ws/4tlNlce RIVIAN MAKES FOUR RAN SITES NACS-ONLY https://evne.ws/4cgCLx4 HONDA SUPER-N SET FOR UK JULY LAUNCH https://evne.ws/3QvWctf MAV SYSTEMS LAUNCHES BAYIQ FOR EV BAYS https://evne.ws/3OJx5mg

"VARIANTS AND MUTATIONS" Dr Stella joins the show to have the discussion. Tonight at 10pm ET on Lindell TV. #DiamondandSilk http://DiamondandSilkMedia.com Use Promo Code: DIAMOND or TRUMPWON 1. http://DiamondandSilkStore.com2. https://thedrardisshow.com/shop-all/?aff=123. http://PatchThat.com4. https://cardiomiracle.com/?ref=DIAMOND5. https://MyPillow.com/TrumpWon6. https://DrStellaMD.com7. https://www.Curativabay.com/?aff=18. http://MaskDerma.comSee omnystudio.com/listener for privacy information.

On this episode, Seriah is joined by Brennan and Saxon, and they discuss their experiences with Shadow People, the variations therein and what some would call a sort of "living darkness".Outro Music is The Douglas 57 with No Clear Photos.Become a Patreon at https://www.patreon.com/c/SeriahAzkath for extra content, commercial free shows, early access, and bonus content as well! on $3 a month!

Even as I was editing this update, even more news just broke! A listening party will be held in LA next week, April 16th 5PM PST for "The Boys of Dungeon Lane" Wow! The Dungeon Lane news cycle has kept us pretty busy here on 2Legs. For this episode Andy and Tom give an overview of all the vinyl and CD variants for the new album as well as updates on Paul's SNL appearance and the Wings Rock and Roll Hall of Fame Exhibition opening the same weekend! Join us in Cleveland in May! Andy & Tom https://www.patreon.com/c/2LegsPodcast https://www.facebook.com/2LegsPodcasts

Kelli Williams aka @Laguna_Biotch is back to talk about these crazy young-ish people on bravo starting from the oldest, the Valley, to the sort of young-ish in Summer House and then the youngest babies born well well well before 9/11 - Southern Hospitality

Tonight we'll be spotlighting characters that have had a ton of different VARIATIONS over the years. Think costumes, alternate dimensions and even the dreaded heel turn! We plumbed the depths of video games and comic books to find just the right candidates to create quite the motley crew for you to enjoy. Ever see #Batman on the same list as #SimonBelmont ? Well, now you have! And the medium that shows off these different versions of our characters can be anything. Action figures, cartoons, games, comics and movies. For this episode, we are all over the place! RETRO RIDOCTOPUS is ----------------------------------- "Parasite Steve"...... AKA Steve Van Samson (read) "8-Bit Alchemy "...... AKA Tim Krikorian (listen) "Coopster Gold"...... AKA Justin Cooper (subscribe) ------------------------------------------------------------------------- Show your RETROID PRIDE! Get your official GEAR right here! ------------------------------------------------------------------------- Retro Ridoctopus is a proud member of The Dorkening Podcast Network and is brought to you by Deadly Grounds Coffee. Podcast intro and all heavy metal interstitials by Enchanted Exile.

When to test, how to prevent, and what you need to know about hereditary gynecologic cancer syndromes. Two USC gynecologic oncologists, Dr. Mona Guo and Dr. Marcia Ciccone, go in-depth in this BackTable OBGYN x Tumor Board crossover episode. --- Get the BackTable app https://www.backtable.com/app --- Timestamps 00:00 - Introduction01:37 - Why Hereditary Cancer Matters04:51 - Family History Red Flags09:01 - Who Should Order Genetic Testing11:32 - Variants and Counseling Pitfalls13:30 - Access and Remote Testing Options19:27 - BRCA1 Positive Patient Walkthrough24:52 - Risk-Reducing Surgeries29:11 - Prevention and Screening Limits32:38 - Why Ovarian Cancer Is Hard34:04 - Combining Breast and Gyn Surgery35:41 - Preop Ultrasound and CA-12536:27 - BRCA Timing and HRT Nuance42:32 - Nonhormonal Menopause Options47:14 - Lynch Syndrome Screening Basics54:22 - Endometrial Biopsy Debate56:43 - Insurance and Coverage Pitfalls59:00 - Fertility Preservation and REI01:01:41 - Cascade Testing01:02:45 - Conclusion --- More about this episode Dr. Guo and Dr. Ciccone discuss how careful family history can identify patients who may benefit from genetic evaluation and highlight key red flags, including a family history of ovarian cancer, breast cancer at age 50 or younger, and metastatic prostate cancer. They explain the role of genetic counseling, including pre- and post-test discussions and how to approach variants of uncertain significance. They then cover BRCA counseling and risk-reduction strategies, including the timing of risk-reducing bilateral salpingo-oophorectomy, ongoing salpingectomy trials, and considerations for hysterectomy. Additionally, they touch on pathology protocols, breast cancer screening, and the potential protective effect of hormonal contraception. The doctors address the limitations of ovarian cancer screening and outline patterns suggestive of Lynch syndrome, such as endometrial cancer occurring alongside gastrointestinal or urinary tract cancers. They review the Lynch workup, including tumor mismatch repair immunohistochemistry and MLH1 hypermethylation testing. Finally, they discuss practical considerations like barriers to access, Medicare coverage challenges, fertility preservation referrals, menopause management, and cascade testing in families, including the timing of testing in children. --- Resources NCCN Guidelines: Detection, Prevention, and Risk Reductionhttps://www.nccn.org/guidelines/category_2

Adjusting genetic analyses could help plug autism's heritability gap, according to a new preprint.

The genetic variants initially affect brain development in unique ways, but over time they converge on common molecular pathways.

With this episode, it addresses a few variants that we came across for the game of blackjack and includes specialty hands that can be made along with unique side bets the players are able to make.  With that said, if you know any additional variants to blackjack, we're interested in hearing them.  If we get enough suggestions, along with an accompanying ruleset for said variants, we may do a follow-up episode on the matter.  With that said, we hope you enjoy this episode and of course, happy gaming.CreditsWriter - Bradley P. ThomasProducer - Bradley P. ThomasVoice Talent – ElevenLabs: TaylorEditor - Bradley P. Thomashttps://linktr.ee/Check_Point_GamingCopyright Disclaimer:Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education, and research.  Fair use is a use permitted by copyright statute that might otherwise be infringing.  Non-profit, educational, or personal use tips the balance in favor of fair use.https://www.copyright.gov/legislation/dmca.pdf

Understanding the Complexities of General Partnership Formation and LiabilityThis conversation provides an in-depth exploration of general partnership law, focusing on the complexities of partnership formation, liability, fiduciary duties, and the evolution of partnership structures. The discussion emphasizes the importance of understanding the legal implications of partnerships, including the risks involved and the distinctions between different types of partnerships, such as general partnerships, limited partnerships, and limited liability partnerships. Key themes include the nature of partnership relationships, the responsibilities of partners, and the legal frameworks that govern these entities.In the intricate world of business law, the formation and management of partnerships can be a minefield of potential liabilities and legal traps. This blog post explores the nuances of general partnerships, a common yet often misunderstood business entity.Introduction: The Wild West of Business LawGeneral partnerships are frequently referred to as the "default" business entity, but this term can be misleading. Unlike the default settings on your phone, which are designed for safety and ease, general partnerships are fraught with personal liability risks and legal complexities. This post aims to unpack these challenges, providing insights for law students, bar exam candidates, and business owners alike.Formation: The Unseen TrapsA general partnership can be formed without any formal agreement, simply through the conduct of the parties involved. This means that even without intending to, individuals can find themselves in a binding legal relationship that exposes their personal assets to risk. The Uniform Partnership Act (UPA) and the Revised Uniform Partnership Act (RUPA) provide the legal framework, but understanding the friction between these laws is crucial for navigating potential pitfalls.Liability: The Joint and Several ConundrumOne of the most daunting aspects of general partnerships is the concept of joint and several liability. This means that each partner can be held personally liable for the entire debt of the partnership, regardless of their individual share. The RUPA offers some protection through the "exhaustion rule," requiring creditors to first seek repayment from the partnership's assets. However, in jurisdictions following the older UPA, creditors can directly target individual partners.Conclusion: Navigating the Legal LandscapeThe evolution of partnership law reflects a balancing act between flexibility and protection. As business law continues to evolve, understanding these legal frameworks is essential for anyone involved in a partnership. Whether you're a law student preparing for exams or a business owner managing a partnership, staying informed about these legal intricacies can help mitigate risks and ensure a more secure business environment.Subscribe NowStay updated with the latest insights in business law by subscribing to our newsletter. Don't miss out on expert analysis and practical advice to navigate the legal landscape of partnerships.TakeawaysThe general partnership is often called the default business entity, but it is misleadingly dangerous.Intent to form a partnership is based on conduct, not subjective intent.Profit sharing is prima facie evidence of partnership under UPA.Partnership by estoppel can create liability without a formal partnership.In a general partnership, all partners are jointly and severally liable for debts.The default rule for profit sharing is equality, regardless of contribution.Service partners must contract around default rules to protect their interests.Fiduciary duties require partners to act in the best interest of the partnership.Every partner has authority to act on behalf of the partnership unless limitedgeneral partnership, business law, liability, partnership formation, fiduciary duties, limited partnership, LLP, UPA, RUPA, agency law

In this episode I dicuss the following DJ Spin -

Certain gene variants may have greater weight in determining autism likelihood for some populations, a new study shows.

As flu cases climb across the country and pediatric deaths rise, Dr. Natasha Bagdasarian, ASTHO member and Michigan's Chief Medical Executive, joins us to break down what this flu season means for families, health agencies, and health care systems.  Dr. Bagdasarian discusses the troubling decline in flu vaccine uptake since 2020, the risks of overlapping surges of flu, COVID-19, and RSV, and why flu vaccination remains critical, even when it doesn't prevent every infection. She explains how vaccines reduce severe illness and hospitalizations, helping protect already-strained health systems. The conversation also explores vaccine hesitancy during pregnancy, the importance of maternal vaccination, and how personal stories paired with data can help rebuild trust. Dr. Bagdasarian shares insight into the emerging H3N2 subclade K flu strain, what early data shows about vaccine effectiveness, and how public health officials are tracking flu trends using multiple surveillance tools.Meeting Home Page

On this episode, Seriah is joined by Brennan and Saxon, and they discuss their experiences with Shadow People, the variations therein, and what some would call a sort of living Darkness...Outro Music is The Douglas 57 with No Clear Photos.Become a Patreon at https://www.patreon.com/c/SeriahAzkath for extra content, commercial free shows, early access, and bonus content as well! on $3 a month! Hosted on Acast. See acast.com/privacy for more information.

Dr Jeremy Clark unpacks why leukodystrophy caused by biallelic HMBS variants does not respond to liver transplantation or hepatically targeted therapies, pointing instead to CNS-driven porphyrin toxicity and a need for entirely new management approaches. Liver Transplantation and Other Hepatically Directed Therapies Do Not Change the Biochemical Phenotype nor Halt Progression of Leukodystrophy due to Biallelic HMBS Variants: A Case Report Jeremy Clark, et al https://doi.org/10.1002/jmd2.70056

In this episode of The New Quantum Era, Sebastian talks with Hrant Gharibyan, CEO and co‑founder of BlueQubit, about “peaked circuits” and the challenge of verifying quantum advantage. They unpack Scott Aaronson and Yushuai Zhang's original peaked‑circuit proposal, BlueQubit's scalable implementation on real hardware, and a new public challenge that invites the community to attack their construction using the best classical algorithms available. Along the way, they explore how this line of work connects to cryptography, hardness assumptions, and the near‑term role of quantum devices as powerful scientific instruments.Topics CoveredWhy verifying quantum advantage is hard The core problem: if a quantum device claims to solve a task that is classi-cally intractable, how can anyone check that it did the right thing? Random circuit sampling (as in Google's 2019 “supremacy” experiment and follow‑on work from Google and Quantinuum) is believed to be classically hard to simulate, but the verification metrics (like cross‑entropy benchmarking) are themselves classically intractable at scale.What are peaked circuits? Aaronson and Zhang's idea: construct circuits that look like random circuits in every respect, but whose output distribution secretly has one special bit string with an anomalously high probability (the “peak”). The designer knows the secret bit string, so a quantum device can be verified by checking that measurement statistics visibly reveal the peak in a modest number of shots, while finding that same peak classically should be as hard as simulating a random circuit.BlueQubit's scalable construction and hardware demo BlueQubit extended the original 24‑qubit, simulator‑based peaked‑circuit construction to much larger sizes using new classical protocols. Hrant explains their protocol for building peaked circuits on Quantinuum's H2 processor with around 56 qubits, thousands of gates, and effectively all‑to‑all connectivity, while still hiding a single secret bit string that appears as a clear peak when run on the device.Obfuscation tricks and “quantum steganography” The team uses multiple obfuscation layers (including “swap” and “sweeping” tricks) to transform simple peaked circuits into ones that are statistically indistinguishable from generic random circuits, yet still preserve the hidden peak.The BlueQubit Quantum Advantage Challenge To stress‑test their hardness assumptions, BlueQubit has published concrete circuits and launched a public bounty (currently a quarter of a bitcoin) for anyone who can recover the secret bit string classically. The aim is to catalyze work on better classical simulation and de‑quantization techniques; either someone closes the gap (forcing the protocol to evolve) or the standing bounty helps establish public trust that the task really is classically infeasible.Potential cryptographic angles Although the main focus is verification of quantum advantage, Hrant outlines how the construction has a cryptographic flavor: a secret bit string effectively acts as a key, and only a sufficiently powerful quantum device can efficiently “decrypt” it by revealing the peak. Variants of the protocol could, in principle, yield schemes that are classically secure but only decryptable by quantum hardware, and even quantum‑plus‑key secure, though this remains speculative and secondary to the verification use case. From verification protocol to startup roadmap Hrant positions BlueQubit as an algorithm and capability company: deeply hardware‑aware, but focused on building and analyzing advantage‑style algorithms tailored to specific devices. The peaked‑circuit work is one pillar in a broader effort that includes near‑term scientific applications in condensed‑matter physics and materials (e.g., Fermi–Hubbard models and out‑of‑time‑ordered correlators) where quantum devices can already probe regimes beyond leading classical methods.Scientific advantage today, commercial advantage tomorrow Sebastian and Hrant emphasize that the first durable quantum advantages are likely to appear in scientific computing—acting as exotic lab instruments for physicists, chemists, and materials scientists—well before mass‑market “killer apps” arrive. Once robust, verifiable scientific advantage is established, scaling to larger models and more complex systems becomes a question of engineering, with clear lines of sight to industrial impact in sectors like pharmaceuticals, advanced materials, and manufacturing.The challenge: https://app.bluequbit.io/hackathons/

The Gemara makes one final attempt to answer the question of whether the airspace of the altar can sanctify disqualified items just as the altar does. The attempt is rejected. The Mishna teaches that liquid sacred vessels sanctify liquids, and vessels used for dry ingredients sanctify dry items. Liquid vessels cannot sanctify dry items, nor vice versa. If sacred vessels are punctured, they only sanctify if they can still perform their original function and remain whole. All sanctification occurs only within the Azara. Shmuel limits the first ruling of the Mishna to measuring utensils, but bowls and similar items can sanctify even dry ingredients. His proof is a verse regarding flour mixed with oil that was placed into a bowl generally used for liquids (Bamidbar 7:13). Rav Acha questions this proof since flour mixed with oil is not exactly a solid, and Shmuel provides two possible answers. Shmuel further rules that sacred vessels sanctify only when they are whole, filled with the entire amount needed for the offering, and can only sanctify items from within. Variants of this teaching differ slightly, as one version reads "from inside the Azara" instead of "from within the vessel" and another includes both. The difference between two of these versions is whether overflow is sanctified. Rabbi Yohanan qualifies the ruling that if there is not a complete amount, the item inside will not be sanctified. He explains that this applies only when there was no intent to reach the full amount, but if one intends to add enough to reach the requisite measure, each portion becomes sanctified as it is placed inside. A braita is brought to support this. Rav or Rav Asi qualifies the Mishna's ruling that dry vessels do not sanctify liquids and vice versa. This applies to sanctification for offering on the altar, but they are sanctified to the extent that the contents can become disqualified. Some say his statement was made regarding a different braita about meal offerings brought from orla and diverse kinds. A braita teaches that damaged sacred vessels cannot be repaired by melting or patching. Similarly, knives with defects cannot be sharpened to remove the blemish, and if a blade slips out, it cannot be reattached. This ruling reflects the principle that there is "no poverty in a place of affluence," referring to the Temple as a place of affluence. Abba Shaul recalls a defective knife in the Temple that was buried so that is would not be used. Another braita, based on the same principle, explains that the clothes of the kohanim must be woven, not stitched, and if they become soiled, they cannot be washed with cleaning agents such as natron or soap. Abaye clarifies that they can be laundered if only mildly dirty, but if cleaning them would require agents, they cannot be cleaned even with water alone. Some say they may never be washed at all. A braita describes the kohen gadol's robe as entirely blue, with hem decorations resembling unopened pomegranates and children's buttons. Bells were attached, either seventy‑two in total or thirty‑six according to differing opinions. Rabbi Anani bar Sasson notes that this dispute parallels disagreements about the number of shades in leprous afflictions. Rabbi Anani bar Sasson explains that the Torah juxtaposes sacrifices with priestly garments to teach that just as sacrifices atone, so too do the garments. Each garment corresponds to atonement for a specific sin: the tunic for murder, the pants for sexual immorality, the turban for arrogance, the belt for improper thoughts, the breastplate for judicial errors, the ephod for idolatry, the robe for lashon hara, and the tzitz for brazenness. The Gemara raises a difficulty from the statement of Rabbi Yehoshua ben Levi, who taught that murder and lashon hara have no atonement through sacrifices, only through other means - egla arufa for murder and ketoret, incense, for slander. The difficulty is resolved by distinguishing between situations: when the murderer is known, the tunic atones; when unknown, the egla arufa atones. Regarding lashon hara, they distinguish between public lashon hara, which is atoned by the robe with its bells, and private lashon hara, atoned by the ketoret, which is offered in the sanctuary, a private space.

Is the Bible we read today the same one the prophets, apostles, and early church had? In this episode, we put the Scriptures under the microscope—textual criticism, the Dead Sea Scrolls, manuscript counts, famous variants (like John 7:53–8:11 and Mark 16:9–20), and the claim of “400,000 errors.” We'll show why the integrity of the Bible matters for the Gospel, for trusting Jesus (John 10:35), and for your everyday evangelism.What you'll learn:Why this question isn't a side issue—it's about the trustworthiness of the Gospel and of Christ Himself.OT reliability: Masoretic Text vs. Dead Sea Scrolls—how close are we to the originals?NT reliability: the bibliographical test, thousands of manuscripts, and how variants are weighed.The “400,000 variants” claim—what counts as a variant, and why the vast majority don't change meaning.Big textual questions (e.g., Longer Ending of Mark, Woman Caught in Adultery, Johannine Comma) and why identifying them strengthens confidence.Why alternative “final authorities” never face the same scrutiny—and why Scripture stands.===============================Resources mentioned: Ketef Hinnom Scrolls: https://ketefhinnomsilverscrolls.github.io/about.htmlIntroduction to Textual Criticism pt. 1: https://www.aomin.org/aoblog/textual-issues/an-introduction-to-textual-criticism-part-3-textual-errors/Introduction to Textual Criticism pt. 3: https://www.aomin.org/aoblog/textual-issues/an-introduction-to-textual-criticism-part-3-textual-errors/Ed Gravely - Aren't There 400,000 Variants in the NT? https://www.youtube.com/watch?v=gieq2fYH9gs https://www.aomin.org/aoblog/textual-issues/an-introduction-to-textual-criticism-part-1-introduction/=================================If this helped you:

In this vital Options Bootcamp episode, host Mark Longo from The Options Insider provides an in-depth tutorial on butterfly spread strategies alongside guest Brian Overby from OptionsPlaybook.com. They explore both traditional and advanced butterfly strategies—including the Open Wing Butterfly (often known as a Broken Wing Butterfly) and the Intrinsic Value Butterfly—explaining their practical options trading applications and defined risk/reward benefits. This is essential options trading education for neutral, low-volatility markets. Additionally, they address a listener's puzzling options scenario involving Marvell ($MRVL) stock and offer clear resolution strategies for similar trading challenges, emphasizing proper broker interaction and order management.

In this vital Options Bootcamp episode, host Mark Longo from The Options Insider provides an in-depth tutorial on butterfly spread strategies alongside guest Brian Overby from OptionsPlaybook.com. They explore both traditional and advanced butterfly strategies—including the Open Wing Butterfly (often known as a Broken Wing Butterfly) and the Intrinsic Value Butterfly—explaining their practical options trading applications and defined risk/reward benefits. This is essential options trading education for neutral, low-volatility markets. Additionally, they address a listener's puzzling options scenario involving Marvell ($MRVL) stock and offer clear resolution strategies for similar trading challenges, emphasizing proper broker interaction and order management.

Send us a textDr. Katherine P Callahan, neonatologist and bioethicist at Children's Hospital of Philadelphia, discusses the complexity of genetic testing in neonatal care. While the NICU serves as a launch point for genetic technologies due to high prevalence of genetic disease, genetic information is often ambiguous or uncertain rather than straightforwardly diagnostic. Variants of uncertain significance represent just one challenge—even clearly pathogenic findings may have unclear implications for individual patients, as demonstrated when parents carry the same mutation as their severely affected child. Callahan emphasizes that genetic information poses "informational hazards" requiring careful consideration of psychological and ethical impacts. She advocates for acknowledging complexity, rethinking outcomes beyond traditional measures, and embracing shared decision-making rather than standardized approaches to genomic counseling. Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

You are listening to a presentation given at the 2025Michigan Conference Cedar Lake Campmeeting. We pray you will be blessed!

You are listening to a presentation given at the 2025Michigan Conference Cedar Lake Campmeeting. We pray you will be blessed!

Goose Island's annual Bourbon County Stout lineup will be released on Black Friday!  WGN Radio's Dave Plier talks to Todd Ahsmann, President of Goose Island, Mike Siegel, Goose Island Senior Innovation Manager, and Brian Noonan & Cody Gough from the Crafty Brewers podcast about this time-honored tradition, the history, the process, and why Bourbon County […]

Welcome back to another episode of the Online Warriors Podcast! This we have a very special episode for you. We're covering some movie and gaming news! - Super Mario Galaxy Trailer (1:41) - Metroid Prime 4 Trailer (4:31) - New Pokémon Variants (11:09) - Steam Machine (13:32) Then we discuss what Techtic's been up to: - Techtic watches No Body Wants This, goes to a Meat Raffle, and works on his game (19:41) Special shoutout to our Patreon Producer: Steven Keller! We'd like to thank each and every one of you for listening in every week. If you'd like to support the show, you can drop us a review on your favorite podcast platform or, if you're feeling extra generous, drop us a subscribe over at Patreon.com/OnlineWarriorsPodcast. We have three tiers of subscriptions, each of which gives you some awesome bonus content! As always, we appreciate you tuning in, and look forward to seeing you next week! Stay safe and healthy everyone! Find us all over the web: Online Warriors Website: https://www.onlinewarriorspodcast.com Online Warriors Twitter: https://twitter.com/onlinewarriors1 Illeagle's Twitter: https://twitter.com/OWIlleagle86 Nerdbomber's Twitter: https://twitter.com/OWNerdbomber Techtic's Twitter: https://twitter.com/OWTechtic Facebook: https://www.facebook.com/onlinewarriorspodcast Instagram: https://www.instagram.com/onlinewarriorspodcast/ YouTube: https://www.youtube.com/channel/UCwOwzY6aBcTFucWEeFEtwIg Merch Store: https://onlinewarriorspodcast-shop.fourthwall.com/

Become Part of our Community or Take our Free Personality Test!: https://linktr.ee/csjoseph CS Joseph Discusses The Four Octagram Variants of The INFP in this previously unreleased lecture series, enjoy

Become Part of our Community or Take our Free Personality Test!: https://linktr.ee/csjoseph CS Joseph Discusses The Four Octagram Variants of The INTP in this previously unreleased lecture series, enjoy

00:46 A multi-variant avian flu vaccine that could enhance pandemic preparednessA vaccine capable of protecting against multiple strains of avian influenza virus may be a step closer, according to new research. The H5 subtype of avian influenza viruses has spilled over into mammals and is particularly concerning to researchers due to the risk of them evolving to cause another pandemic. But because there are multiple variants of these viruses, it has been hard to pre-prepare vaccines. Now, a team have used information on how these viruses evolved over time to design a vaccine that in animal studies provided protection against different H5 strains. They hope their approach could be applied to create stockpiles of vaccine that could be used in the event of a pandemic, regardless of the strain that causes it.Research Article: Kok et al.10:53 Research HighlightsMaking muon beams without a huge particle accelerator — plus, the bats hunting migrating birds in mid-air.Research Highlight: Portable muon beam could accelerate archaeology scansResearch Highlight: European bats capture migrating birds and eat them on the wing13:34 Briefing ChatA new search engine that can sift through the staggering volumes of biological data, and the multiple failings revealed by an assessment of 25 years of carbon offsetting data.Nature: ‘Google for DNA' brings order to biology's big dataThe Guardian: Carbon offsets fail to cut global heating due to ‘intractable' systemic problems, study says​​​​​​​Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.