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“If the asthma is under good control but they are still having these episodes, then I do think that maybe they have a PVFMD component to their breathing issue.” Dr. R. Jun LinPatients come into clinic short of breath. It hits during exercise, it looks dramatic, and they may even describe noisy breathing or the feeling that they “can't get air in.” So we do what clinicians do: we think asthma. We try inhalers. But sometimes, no matter how many puffers are thrown at the problem, nothing changes.That's when it may be time to look higher, to the larynx.On this episode of The Allergist, Dr. Mariam Hanna is joined by Dr. R. Jun Lin, a fellowship-trained laryngologist and chief of the Division of Laryngology at the University of Toronto, for a practical discussion of vocal cord dysfunction, inducible laryngeal obstruction, and paradoxical vocal fold motion disorder. Dr. Lin walks through how these patients present, how to distinguish laryngeal obstruction from asthma, when both may be present, and why respiratory retraining therapy is often the cornerstone of care.Key PointsVCD, ILO, EILO, and PVFMD describe the same basic problem through different specialty lenses.The key clue: trouble breathing in, not out.In teens, it often shows up during warm-up or early competition.In adults, common triggers include perfume, bleach, gasoline, cooking fumes, cold air, humidity, speaking, or laughing.Asthma and PVFMD can coexist. If asthma is controlled but symptoms persist, think larynx.Laryngoscopy is often normal in PVFMD, but helps rule out structural causes.Respiratory retraining therapy is the cornerstone of treatment.Pursed-lip breathing can reduce the severity and duration of episodes, but patients need to practise it before symptoms peak.Food triggers, urticaria, tongue swelling, or rash point away from PVFMD.Botox is a last resort, not first-line treatment.For clinicians, this episode is a reminder that not every dramatic breathing episode starts in the lower airway. When the history points to trouble getting air in, especially with poor response to inhalers, PVFMD deserves a place on the differential.Have an idea for the show or a comment, send us a text!Visit the Canadian Society of Allergy and Clinical ImmunologyFind an allergist using our helpful toolFind Dr. Hanna on X, previously Twitter, @PedsAllergyDoc or CSACI @CSACI_caThe Allergist is produced for CSACI by PodCraft Productions
“AI might feel like magic at times, but mostly it's just powerful technology, and with any technology, it's a tool.” —Merlijn van BreugelAI is no longer a future-tense possibility for allergists. It is already shaping diagnosis, prediction, documentation, patient communication, and the way clinicians think through complex decisions. But if AI can process more than we can, what still belongs to the clinician?On this episode of The Allergist, Dr. Mariam Hanna is joined by Merlijn van Breugel, a data scientist and philosopher whose work focuses on AI in allergy and immunology. Together, they get into where AI may be most useful now and in the near future, including phenotyping asthma and eczema, supporting diagnosis in young children, combining genetic, environmental, wearable, and clinical data, and reducing the administrative work that pulls clinicians away from patient care. But the episode does not dodge the hard stuff: hallucinations, bias, validation, liability, overtrust, and the very human problem of changing behaviour in real clinics.Key PointsAllergy and immunology are not early adopters of AI, partly because the field relies on complex, heterogeneous data.AI is most promising when it helps reveal patterns clinicians struggle to synthesize on their own, such as asthma or eczema subtypes.Large language models can hallucinate, so clinicians need to stay critical even when an answer sounds polished and convincing.Decision-support tools should augment clinical judgment, not replace it.Bias in training data can create real harm if AI tools work better for some patient populations than others.The best use cases are significant, underserved problems where AI can do something that older tools could not.AI literacy will become a core skill for clinicians who want to use these tools safely and effectively.For allergists, the message is not to fear the machine or blindly follow it. AI may help identify patterns, reduce administrative work, and open new research possibilities, but the clinician still brings the judgment, context, accountability, and critical eye. The future is not AI instead of allergists. It is allergists who understand how to use AI well.Have an idea for the show or a comment, send us a text!Visit the Canadian Society of Allergy and Clinical ImmunologyFind an allergist using our helpful toolFind Dr. Hanna on X, previously Twitter, @PedsAllergyDoc or CSACI @CSACI_caThe Allergist is produced for CSACI by PodCraft Productions
Send us Fan MailFood allergies can feel incredibly overwhelming for parents — especially during infancy when introducing new foods for the first time. What does a true allergic reaction actually look like? And what should families know about new treatment options for food allergies?In this episode, Dr. Jessica Hochman sits down with allergist Dr. Akansha Ganju of Latitude Food Allergy Care to discuss the latest science around food allergies, eczema, early allergen introduction, and oral immunotherapy (OIT).They discuss:Why early allergen introduction mattersThe connection between eczema and food allergiesWhat mild vs severe allergic reactions look likeWhy many first food reactions in babies are usually mildCommon misconceptions about food allergy testingHow OIT works and which children may benefitThe role of Xolair in food allergy treatmentWhy food allergy treatment is changing rapidlyThis episode is packed with practical advice, reassurance, and evidence-based guidance for families navigating food allergies.To learn more about Dr. Ganju and Latitude Food Allergy Care, visit:Latitude Food Allergy CareInstagram:Latitude Food Allergy Care InstagramYour Child is Normal is the trusted podcast for parents, pediatricians, and child health experts who want smart, nuanced conversations about raising healthy, resilient kids. Hosted by Dr. Jessica Hochman — a board-certified practicing pediatrician — the show combines evidence-based medicine, expert interviews, and real-world parenting advice to help listeners navigate everything from sleep struggles to mental health, nutrition, screen time, and more. Follow Dr Jessica Hochman:Instagram: @AskDrJessica and Tiktok @askdrjessicaYouTube channel: Ask Dr JessicaIf you are interested in placing an ad on Your Child Is Normal click here or fill out our interest form.-For a plant-based, USDA Organic certified vitamin supplement, check out : Llama Naturals Vitamin and use discount code: DRJESSICA20-To test your child's microbiome and get recommendations, check out: Tiny Health using code: DRJESSICA The information presented in Ask Dr Jessica is for general educational purposes only. She does not diagnose medical conditi...
This week on The Hamilton Review Podcast, we're pleased to welcome Dr. Akansha Ganju. Dr. Akansha Ganju is a board-certified allergist and immunologist with a passion for delivering comprehensive, patient-centered care for both adults and children with allergic conditions. She leads Latitude's Los Angeles clinic in West LA, providing specialized life-changing care for food allergy patients of all ages. In this must listen episode, Dr. Ganju discusses food allergies in children and the steps an immunologist can take to diagnose and create a personalized treatment plan for the child and their family. Prior to joining the Latitude team, Dr. Ganju was the Medical Director at Nectar Allergy Center where she played a pivotal role in developing and expanding the startup's inaugural clinic for innovative allergy treatment. Dr. Ganju graduated from an accelerated, combined baccalaureate-M.D. program and received her medical degree from Northeast Ohio Medical University. She is board-certified in internal medicine and completed her residency at Riverside Methodist Hospital in Columbus, Ohio. She went on to complete her allergy and immunology fellowship at UCLA and the VA Greater Los Angeles Healthcare System. Dr. Ganju has authored numerous publications in peer-reviewed journals, conducted both basic science and clinical research, and often presents at healthcare conferences. She is a member of the American Academy of Allergy, Asthma & Immunology (AAAAI) and American College of Allergy, Asthma, and Immunology (ACAAI). How to contact Dr. Akansha Ganju: Dr. Akansha Ganju on Instagram Latitude Food Allergy Care Latitude Food Allergy Care on Instagram Latitude Food Allergy Care on Facebook How to contact Dr. Bob: Dr. Bob on YouTube: https://www.youtube.com/channel/UChztMVtPCLJkiXvv7H5tpDQ Dr. Bob on Instagram: https://www.instagram.com/drroberthamilton/ Dr. Bob on Facebook: https://www.facebook.com/bob.hamilton.1656 Dr. Bob's Seven Secrets Of The Newborn website: https://7secretsofthenewborn.com/ Dr. Bob's website: https://roberthamiltonmd.com/ Pacific Ocean Pediatrics: http://www.pacificoceanpediatrics.com/
There are growing concerns that the science behind many allergy tests just doesn’t stack up — and they could be sending people down the wrong path. We get expert advise from Dr. Shireen Marzouk, Consultant Paediatrician & Allergist at Circle Care Clinic in Dubai. Plus, we learn about art therapy for children, and an app that motivates children to do chores around the house - in exchange for rewards. See omnystudio.com/listener for privacy information.
What do you do when your child has that first allergic reaction—and your allergist appointment is still weeks, maybe even months, away? That in-between time can feel overwhelming, with so many questions and not enough answers. We're sitting down with FAACT Medical Advisory Board Member, Dr. Justin Greiwe, to walk through practical steps families can take right now to stay safe, feel more confident, and navigate this uncertain window. Resources to keep you in the know:FAACT's Newly Diagnosed sectionFAACT's Newly Diagnosed GuideFAACT's Living With Food Allergies Resource CenterYou can find FAACT's Roundtable Podcast on Apple Podcast, Pandora, Spotify, Podbay, iHeart Radio or wherever you listen to your podcasts.Follow us on Facebook, Instagram, BlueSky, Threads, LinkedIn, Pinterest, TikTok, and YouTube.Sponsored by: ARS PharmaThanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!
Allergies can be miserable, and like other threats in the air, can often be invisible but cause a great deal of misery! For this episode, Dr Sharmilee Nyenhuis from the University of Chicago teaches us about pollen, how it affects us, and how it is changing. Listen and learn! Know your own allergies, and make a plan for that pollen season- avoiding peak pollen times outdoors, rinsing pollen off your face and maybe your sinuses when you come indoors, keeping windows closed and moreCheck out the Asthma and Allergy Foundation of America Home Checklist for AllergiesFind a pollen counter that actually counts pollen in real time, not based on historic controls. With climate change, history doesn't predict what may be going on outdoorsThe time is always right to run a HEPA filter- if it's not sweeping the pollen from your air, it will be cleaning out pollution or catching viruses. Share this episode with a friend who suffers from allergies.For more on the interaction of climate change and plant biology, listen to the “Science over Politics” episode from Season One. Consider a donation to the American Lung Association, who works hard to help those with asthma and allergies breathe better-----------------------------------------------------------------------------------------For more information go to airhealthourhealth.org.Follow on Facebook and Instagram. Pollen image by Alex Jones on Unsplash
Allergy season is in full swing and more than 80 million Americans suffer with seasonal allergies.How does this year compare to years in the past? Are people going to be sniffling more, or is this year going to finally be a downturn in pollen?We'll get the answers from a local allergist.Conservation can take on many forms. It can involve protecting animals, plants, forests or any of Earth's natural resources.We are going to meet a woman who has dedicated herself to protecting and preserving wildlife areas, including The Dawes Arboretum in Newark.For many young people, a little guidance and mentorship can be life changing.When someone dedicates themselves to being that change, their community grows and prospers.We'll talking with an individual who has worked for decades to teach and help young people to reach their full potential through various initiatives and programs.It's all coming up on this week's edition of Fascinating Ohio.Guests:Dr. Summit Shah, allergist/founder, Premier Allergy & AsthmaHolly Latteman, director of science and research, Dawes ArboretumDavid Bush, founder, Madd Poets Society/commissioner of youth civic engagement, City of ToledoIf you have a disability and would like a transcript or other accommodation you can request an alternative format.
Allergy season is in full swing and more than 80 million Americans suffer with seasonal allergies.How does this year compare to years in the past? Are people going to be sniffling more, or is this year going to finally be a downturn in pollen?We'll get the answers from a local allergist.Conservation can take on many forms. It can involve protecting animals, plants, forests or any of Earth's natural resources.We are going to meet a woman who has dedicated herself to protecting and preserving wildlife areas, including The Dawes Arboretum in Newark.For many young people, a little guidance and mentorship can be life changing.When someone dedicates themselves to being that change, their community grows and prospers.We'll talking with an individual who has worked for decades to teach and help young people to reach their full potential through various initiatives and programs.It's all coming up on this week's edition of Fascinating Ohio.Guests:Dr. Summit Shah, allergist/founder, Premier Allergy & AsthmaHolly Latteman, director of science and research, Dawes ArboretumDavid Bush, founder, Madd Poets Society/commissioner of youth civic engagement, City of ToledoIf you have a disability and would like a transcript or other accommodation you can request an alternative format.
“I do not believe we should be testing to test. We have to know, is this test going to change management and is it going to make a difference,” says pediatric allergist-immunologist Dr. Zachary Rubin. His knack for providing that sort of straightforward guidance explains why Dr. Rubin has become a trusted voice on allergies, asthma, and vaccines for his millions of followers on social media platforms. It's also why we couldn't ask for a better guide for our discussion on the rise in allergies, asthma, and immune-related conditions in children, and how families can navigate the quickly evolving science and rampant misinformation in the space. On this episode of Raise the Line, we also preview Dr. Rubin's new book, All About Allergies, in which he breaks down dozens of conditions and diseases, offering clear explanations and practical treatment options for families. Join host Lindsey Smith for this super informative conversation in which Dr. Rubin shares his thoughts on a wide range of topics including: What's behind the rise in allergic and immune-related conditions.Tips for managing misinformation, myths and misunderstandings. How digital platforms can be leveraged to strengthen public health.How to build back public trust in medicine.Mentioned in this episode:All About Allergies bookBench to Bedside PodcastInstagramTikTokYouTube Channel If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast
The Natural Nurse, Ellen Kamhi, talks with Dr. Dean Mitchell, a board-certified allergist, immunologist, and integrative medicine specialist with over 25 years of experience. He is the founder of Mitchell Medical Group in New York City and a national leader in sublingual immunotherapy, a safer and more natural treatment for allergies. Dr. Mitchell is the author of Dr. Dean Mitchell's Allergy and Asthma Solution, which offers an innovative, holistic approach to managing immune and allergic conditions. A graduate of NYU School of Medicine, he is also the host of the Smart Medicine podcast, where he explores cutting-edge strategies for treating chronic illness and restoring vibrant health. www.mitchellmedicalgroup.com
Are we diagnosing allergies all wrong? Join pediatric allergist and clinical immunologist Dr. Zainab Abdurrahman as we debunk common myths in allergy management. We dive deep into why patient history matters more than testing, the danger of using Benadryl, and the life-changing impact of early food introduction. Dr. Abdurrahman also discusses the "diversity gap" in Canadian healthcare, explaining why cultural sensitivity and representation are vital for better patient outcomes. Whether you're a parent, a medical professional, or someone living with allergies, this episode offers a masterclass in modern immunology and health equity. In this episode, we cover: Early Food Introduction: How to reduce allergy risks in infants. Allergy vs. Intolerance: Clearing up the most common misconceptions. The Specialist Shortage: Why Canada needs more pediatric allergists. Cultural Sensitivity: Why representation in medicine saves lives. Learn how to advocate for better care and understand the critical role of social media in spreading accurate allergy awareness. More about Dr. Abdurrahman: Dr. Zainab Abdurrahman, president of the Ontario Medical Association, is an allergist and clinical immunologist, advocating for health equity, medical innovation and inclusive leadership. She brings a strong background in biostatistics and a deep commitment to systemic change. Dr. Zainab Abdurrahman (she/her) is the president of the Ontario Medical Association and a practising allergist and clinical immunologist in the Greater Toronto Area. She serves as an assistant clinical professor of the School of Medicine at the Toronto Metropolitan University and an adjunct assistant clinical professor in pediatrics at McMaster University. Dr. Abdurrahman earned her doctorate of medicine from the University of Toronto. She completed her pediatrics residency and subspecialty training in allergy and clinical immunology at McMaster University. She also holds a master's degree in statistics, with a specialization in biostatistics. She is deeply committed to advancing health and has been a key contributor to the Black Scientists Taskforce on COVID-19 Vaccination Equity and the Black Health & Vaccine Initiative, in partnership with the Black Physicians' Association of Ontario. Beyond equity work, Dr. Abdurrahman is passionate about the intersection of technology and medicine. She is dedicated to leveraging innovation to enhance patient care and is a strong advocate for advancing the medical profession through inclusive leadership and systemic change. https://www.oma.org/expert-advice/request-a-physician-speaker/speakers-search/dr-zainab-abdurrahman/ https://www.qandaallergy.ca/post/dr-a-explains-the-concerns-about-older-sedating-antihistamines Keywords pediatric allergy, immunology, health equity, representation in medicine, food allergies, EpiPen, allergy diagnosis, cultural considerations, adult allergies, social media awareness * Listen on Apple Podcasts – : The Gritty Nurse Podcast on Apple Apple Podcasts https://podcasts.apple.com/ca/podcast/the-gritty-nurse/id1493290782 * Watch on YouTube – https://www.youtube.com/@thegrittynursepodcast Stay Connected: Website: grittynurse.com Instagram: @grittynursepod TikTok: @thegrittynursepodcast Facebook: https://www.facebook.com/profile.php?id=100064212216482 X (Twitter): @GrittyNurse Collaborations & Inquiries: For sponsorship opportunities or to book Amie for speaking engagements, visit: grittynurse.com/contact Thank you to Hospital News for being a collaborative partner with the Gritty Nurse! www.hospitalnews.com
“It's not about knowing each one. It's about knowing the patterns, the warning signs, the general pathways, and knowing when to ask a friend when you're a little bit lost.” —Dr. Tamar RubinOn this episode of The Allergist, Dr. Mariam Hanna turns the focus to how allergists LEARN to recognize when common presentations may signal a deeper immune problem — and how that diagnostic instinct is built, taught, and sustained.She's joined by Tamar Rubin, pediatric allergist and clinical immunologist, Assistant Professor at the University of Manitoba, and a national leader in immunology education. Dr. Rubin makes the case that inborn errors of immunity are not a fringe interest, but central to understanding immunology across allergy, asthma, infection, and biologic therapies — and that allergist-immunologists are the specialists uniquely trained to recognize and teach this.On this episode, they discuss:Why allergist-immunologists “own” inborn errors of immunity, and why teaching these conditions is part of the specialty's responsibilityMoving trainees away from memorizing rare syndromes and toward recognizing immune pathways, patterns, and warning signsHow patient-based teaching, case discussions, OSCEs, and national academic half-day curricula help trainees develop diagnostic “spidey sense”What happens when you build dedicated immunology clinics, and how volume and exposure increase once you start lookingThe importance of national collaboration and collegial networks when managing ultra-rare immune conditionsPractical ways allergists in community practice can stay engaged with inborn errors of immunity, even with limited volume or access to specialized testingKnowing when — and how — to ask for help matters as much as knowing the diagnosis.Because in the end, inborn errors of immunity aren't just about rare diseases. They sharpen how allergists think, teach, and listen when the immune story doesn't quite fit.Have an idea for the show or a comment, send us a text!Visit the Canadian Society of Allergy and Clinical ImmunologyFind an allergist using our helpful toolFind Dr. Hanna on X, previously Twitter, @PedsAllergyDoc or CSACI @CSACI_caThe Allergist is produced for CSACI by PodCraft Productions
== Happy holidays to our audience around the world! As a gift, and a break for The Allergist team, we are replaying our most popular episode from 2025. We hope you enjoy it as much this time around. See you in the New Year! ==“We have to keep in mind that urticaria has to be treated until it's completely gone. So, absolute control of the disease.” — Dr. Hermenio LimaChronic spontaneous urticaria has long been managed with the goal of complete symptom control. But for many patients, that goal remains elusive. In this episode of The Allergist, Dr. Mariam Hanna talks with dermatologist and clinical immunologist Dr. Hermenio Lima about the updated urticaria guidelines—and how new treatment options are giving clinicians more ways to act, and more hope for getting patients all the way to control.On this episode:What's new in the 2025 guideline—including additional second-line options beyond antihistaminesWhy nearly 40% of patients may need to escalate to biologicsHow remibrutinib compares to omalizumab and what its trials revealedWhat the CUPID studies say about dupilumab, especially in biologic-naive patientsKey safety signals and clinical considerations for the new treatment optionsHow to move toward full disease control—and why suboptimal outcomes are no longer acceptableComplete control is still the destination, but the path to get there is about to get a lot more flexible.Visit the Canadian Society of Allergy and Clinical ImmunologyFind an allergist using our helpful toolFind Dr. Hanna on X, previously Twitter, @PedsAllergyDoc or CSACI @CSACI_caThe Allergist is produced for CSACI by PodCraft Productions
Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Fei Li Kuang, MD, PhD, an allergist and immunologist, at Northwestern Medicine, about receiving two APFED HOPE on the Horizon Grants. Disclaimer: The information provided in this podcast is designed to support, not replace, the relationship between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own. Key Takeaways: [:50] Co-host Ryan Piansky introduces this episode, brought to you thanks to the support of Education Partners GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz. [1:14] Holly introduces today's topic, two APFED HOPE on the Horizon Pilot Grant Projects and today's guest, Fei Li Kuang, MD, PhD, an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine in Chicago, Illinois. [1:42] Dr. Kuang is a physician-scientist who takes care of patients with eosinophilic disorders and also performs laboratory research on these disorders in her lab, often using patient samples. Holly thanks Dr. Kuang for joining us. [2:05] As a child, Dr. Kuang always wanted to be a scientist. She is so grateful to live out her childhood dream, and it's because of the amazing people who have supported her, most importantly, her parents. [2:29] In graduate school, Dr. Kuang studied B cells. When she went on to do an allergy fellowship, she thought she would study B cells and care for patients with B cell problems. Instead, she fell in love with allergy and eosinophilic disorders. [2:50] Dr. Kuang is here, in part, because of the different mentors she has had, and in large part, because of the patients she has met along the way. [3:20] Dr. Kuang had the opportunity to work with Amy Klion at the NIH in a clinical trial to treat patients with a drug that gets rid of eosinophils. She says it was a dream come true after her training. [4:02] She says she learned so much about eosinophils, their unusual biology, and the mystery behind what they are here for. She got hooked. [4:15] Dr. Kuang thinks the patients you meet in a clinical trial in a special place like NIH occupy a space in your heart that makes you want to keep working on the subject area. [4:34] Patients in a clinical trial have given up a bunch of their time to travel to Bethesda, Maryland. For the trial Dr. Kuang participated in as a Fellow, it was a good year of their time to come out and do it. [4:47] Dr. Kuang felt there were so many interesting questions, from an intellectual point of view, but there was also a real need from patients with chronic conditions. It was a beautiful opportunity to marry scientists with physicians in training. [5:36] Dr. Kuang shares some knowledge about eosinophils. They are white blood cells that are in all of us. They have little pink packages or granules that "jumped out" in the light microscope almost 200 years ago, when we first identified them. [6:00] Dr. Kuang says that animals, dating back to reptiles, and different species of dolphins, all have eosinophils. A veterinary scientist, Dr. Nicole Stacy of the University of Florida, has taken photos of eosinophils from all these different species. [6:21] They've been around for a long time. What are they good for? What we know is that they are associated with disease conditions, such as asthma and others, including leukemia. Those were the classic first studies of eosinophils. [6:42] Now, we have a different mindset about eosinophils from work by the late James Lee at Mayo Clinic, Arizona. [6:58] Dr. Kuang credits Dr. Lee with suggesting that eosinophils not just cause us problems but also help treat parasitic infections, maintain tissue homeostasis, help wound healing, and tissue repair. That's a new area we are beginning to appreciate. [7:41] Dr. Kuang says we need to be open-minded that in some circumstances, eosinophils may be helpful or innocent. Now we have tools to start to understand some of that. We need to collect information from patients being treated with medicines. [8:10] Ryan tells of being diagnosed as a kid. Doctors explained to him that eosinophils fight parasites, but in some people, they get confused and attack the esophagus. That's EoE. That was easy to understand, but he knew that the researchers knew more. [8:53] Ryan is grateful to the patient population around eosinophilic esophagitis, and is proud of APFED's support of patients and caregivers with HOPE Grants. APFED has the HOPE on the Horizon Research Program, entirely funded by community donations. [9:13] To date, APFED has directed more than $2 million toward eosinophilic disease research initiatives through various grant programs. As a patient advocacy organization, APFED works with fantastic researchers who submit innovative research ideas. [9:32] These research ideas go through an extensive and competitive peer-review process, supported by researchers and clinicians in the APFED community. [9:42] Today, we're going to discuss two different projects supported by HOPE Pilot Grants with Dr. Kuang. [10:00] Dr. Kuang thinks there are two ways these grant programs are important to patients. One is advancing research by nurturing seedling investigators. Dr. Kuang got her first grant when she was a Fellow. It was an incredible opportunity. [10:25] These grant programs also nurture seedling ideas that don't have enough evidence yet to garner the larger NIH grants, and so forth. There are other sources for grants: pharmaceutical companies. The grant programs are for seeds. [10:49] Patients need to know that there are new things that are given some chance of being tested out. Research takes some time, and the FDA process of getting a drug approved is long. [11:04] For the newly diagnosed patient, it can feel overwhelming. It feels like there's a loss of control. Sometimes, participating in something like APFED, being part of a community, gives back a sense of control that is lost when you're handed a diagnosis. [11:45] For patients who have had it for a long time, when they participate in research and become engaged in organizations like APFED, they know they may not directly benefit today, they may benefit later, but they hope future patients will benefit. [12:21] That gives them a sense of control and hope that things will be better for the next generation. We all want that, especially in medicine, in something that we don't have a very deep understanding of. [12:58] Dr. Kuang received two HOPE Pilot Grants, one in 2018 and one in 2022. The first grant was awarded when she was a Fellow at the NIH. [13:05] That first grant explored some effects of eosinophilic depletion of pathogenic lymphocytes in hypereosinophilic syndrome and overlaps with EGIDs. Ryan asks for a broad overview of that research. [13:25] When Dr. Kuang was a Fellow at the NIH, they were doing a Phase 2 clinical trial, looking at "blowing up" eosinophils in patients who have a lot of them, hypereosinophilic syndrome patients. [13:39] They included patients who had eosinophilic GI disease, often beyond the esophagus. They may have esophageal involvement, but sometimes their stomach is impacted, sometimes their large bowel is impacted, with related symptoms. [13:57] What Dr. Kuang and the team noticed in the trial was that just within that little group of patients, there were people who did well, and people who did much better than before, but would have recurrent symptoms, and with no eosinophils in their GI tissues. [14:16] The researchers wanted to know what was causing these problems for the patient. If you take eosinophils away, what other factors will impact the immune system of the patient, semi-long-term? [14:32] Their focus was on these groups of patients who had different responses. They looked at the white blood cells that had been previously described as being the responsible, "bad" T cells that lead to eosinophils in the gut. [14:49] They found that the patients who had recurrent flares of the disease had more of the bad T cells, and the patients who responded well and never complained again about symptoms did not. [15:03] That allowed researchers to identify that there were subsets of patients with the disease that they were calling the same thing. [15:18] Dr. Kuang says that work also led them to find that those cells were being reported in patients who had food allergies for which they needed an epinephrine auto-injector. [15:27] The researchers were curious whether that was just a food allergy issue, or only applied if you had food allergies and eosinophilic GI disease. That HOPE project allowed them to do a pilot study to look at food allergy patients, too. They did, and published it. [15:45] They published that in patients who have a food allergy and have these T cells, the insides of those cells make different messages for the immune system than the ones that the researchers had previously described. [16:01] In looking for why there were differences in those responses, they accidentally found that there were differences inside these cells in a completely different disease, which also had these T cells. [16:21] Dr. Kuang says that the finding was kind of a surprise. If they had found anything in the eosinophilic GI disease patients, that would have been good. They also looked at the epithelial cells and the structure of the GI lining. [16:42] Even though there were no eosinophils in the GI lining in the patients who had been treated with a biologic that depleted eosinophils, their GI lining still looked like the GI lining of patients who had eosinophilic GI disease. [16:55] Dr. Kuang asked what was creating those spots. Our gut lining sheds, so there should have been an opportunity for the GI lining to turn over and look new. Something was there, making signals to create these spots. They did a different publication on that. [17:21] The data from the HOPE Pilot study allowed Dr. Kuang to apply for larger grants. It allowed her to propose to the company that made this drug, when they did the Phase 3 trial, to insert into that special study the study on eosinophilic GI disease. [17:48] Do patients with eosinophilic GI disease do better or worse on this drug, and how do the T cells look in that trial? That HOPE Grant gave Dr. Kuang the data to ask the drug company to give her money to study it in an international cohort of patients. [18:17] There were only 20 patients in that first NIH trial, who gave a year of their life, coming to NIH all the time. They continued to be in the study until the drug was approved for asthma. [18:28] Dr. Kuang says the main reason the company did the Phase 3 trial, which is expensive, and the market share is not huge because it's a rare disease, is that two of the patients went to bat for this disease population. [18:47] The two patients went and showed the business people what they looked like before, what the drug had done for them, and how their lives had changed. It wasn't the doctors or the great paper from the trial, but the patients who convinced the company. [19:01] Dr. Kuang says she was so floored by that and moved by what they did for the community. She is grateful. [19:24] Since the Phase 3 trial, Dr. Kuang and the other researchers realized they had not fully studied the eosinophils. They had studied them in part. They found differences in response. This inspired the second APFED HOPE Pilot Grant. [21:19] In 2022, Dr. Kuang received a two-year APFED HOPE Pilot Grant to examine how blood eosinophils in Eosinophilic Gastrointestinal Diseases differ from those of other eosinophilic diseases and how T cells in EGIDs differ from those in food allergies. [21:49] Dr. Kuang says normally, the biggest place of residence for eosinophils is the GI tract. That's where they are normally seen in people who do not have eosinophilic disorders. [21:59] People who have eosinophilic disorders that attack other parts of the body, asthma, and rarely, the heart. Dr. Kuang was curious to know why one person and not the other? [22:15] Patients who have eosinophilic GI disease often ask, How do you know this high level in the blood is not going to attack my heart or my lungs in the future? Dr. Kuang does not know. [22:29] Dr. Kuang says, looking at the cohort at the NIH, that for many patients who have both GI organ involvement and some other space, when they first went to see a provider, their first complaint was a GI condition. [22:54] If the doctor had only diagnosed a GI condition, nothing else, that would have been wrong. Those patients may not have been monitored as well. A third of the patients originally presented like that. [23:11] What that meant was that we should be paying attention to patients who have GI disease who have lots of eosinophils in their blood. Moving forward, if there are new complaints, we need to investigate. We can't forget they have that. [23:27] Dr. Kuang asks, Wouldn't it be great if we had a better tool than needing to wait? Wouldn't it be great if we had a biomarker that said the eosinophils have switched their target location and are going somewhere else? [23:41] One way to do that is to take different groups of eosinophils and look for differences between those that never target the GI tract and those that do. In patients who have EoE, the eosinophils only target or cause problems in the esophagus. [23:58] Are their eosinophils any different than those of a healthy person, with none of these conditions? That was the goal of that study. [24:10] T cells are another type of white blood cell. They contain a memory of foreign things they have encountered, which allows them to glom onto flu, COVID, peanuts, pollen, that kind of thing. They remember. [24:32] Dr. Kuang says they learned that T cells, at least in the mouse model, are required in the development of eosinophilic esophagitis. The mice in the old study, where mice were forced to develop EoE, did not get EoE if you removed their T cells. [24:50] In the first APFED HOPE grant study, Dr. Kuang found T cells in the blood and tissue of both EGIDs and food allergy patients, but the insides of the T cells were different. The food allergy patients were children recruited by a pediatric allergist. [25:19] In the second APFED HOPE grant study, at Northwestern, Dr. Kuang recruited her adult food allergy patients. That was a way to validate what they found in the first study and move further to better characterize those T cells in the two different diseases. [25:47] Dr. Kuang says we're at a point where we've recruited a lot of people. She says it's amazing what people are willing to do. It's very humbling. [26:06] Dr. Kuang's team in the lab is really great, too. To accommodate patients, they would see them after work, if that's what they had to do to isolate eosinophils. So they did that, and now they are in the process of analyzing that data. It's really exciting. [26:28] What's exciting is that they are seeing results that show that eosinophilic GI disease patients have circulating eosinophils that are different from the eosinophils of people who don't have GI involvement, and from people who have EoE. [26:46] The EoE patients have eosinophils different from those of healthy donors. Dr. Kuang says there's a lot of promise for perhaps unique signatures that could help define these conditions; maybe someday without biopsying, but that's a long time away. [27:16] Dr. Kuang says they will focus on some candidate targets and try to recreate some of that in a dish with eosinophils from healthy people. [27:26] What are the signals that lead eosinophils to do this, and can we translate that back to available drugs that target certain cytokines or other pathways, and maybe give some insight to develop drugs that target other pathways for these diseases? [28:17] Ryan thinks it's exciting that this research is narrowing in on not only the different symptoms, but also how the eosinophils are acting differently in these populations. [28:44] Dr. Kuang is super excited about this research. You could imagine that all eosinophils are the same, but you don't know until you look. When they looked, using the newest technology, they found there were differences. [29:33] Dr. Kuang says it is thought that T cells respond to triggers. We don't think eosinophils have a memory for antigens. T cells do. That's one of their definitions. When T cells react to a trigger, they give out messages through cytokines or by delivery. [30:20] Those are the messages that recruit eosinophils and other cells to come and stir up some trouble. [30:28] In the mouse model, where you don't have the T cells, and you don't get eosinophilic esophagitis in the particular way they made it happen in a mouse, that middle messenger is gone, so the eosinophils don't know where to go. [30:44] With drugs that take out eosinophils, you think that you've gotten rid of the cell that creates all the problems. It shouldn't matter what the message says because there's no cell there to cause the damage. [30:58] What Dr. Kuang learned is that, at least in certain eosinophilic GI diseases, that's not true. You erase the eosinophils from the picture, but that message is still coming. [31:10] Who's carrying out the orders? Or is that message maintaining the wall of epithelial cells in a certain way that we didn't appreciate because the eosinophils were also there? [31:24] It's important to study both, because one is the messenger and the other is one of the actors. Whether all of the actions taken by eosinophils are bad, or maybe some of them were meant to be good, we have yet to learn. [31:40] At the moment, we're using it as a marker for disease activity, and that may change in the future, as we learn more about the roles of these cells in the process. [31:50] We have drugs now that target eosinophils and drugs that target T cells. Dr. Kuang thinks it's important to study both and to study the impact of these drugs on these cells. [32:02] You could theoretically use these drugs to understand whether, if someone responds to it, what happens to these cells, and if someone doesn't respond to it, what happens to these cells, and how this disease manifests in this flavor of patients. [32:54] Dr. Kuang says, Often in science, we take a model. We think this works this way. Then, if this works this way, we expect that if we remove this, these things should happen. We did that with the first clinical trial, with NIH patients. [33:10] It didn't quite happen the way we thought, so we had to go looking for explanations. These were unusual setbacks. Sometimes you have unusual findings, like the food allergy part. [33:24] When Dr. Kuang went to Northwestern, she saw different cohorts of patients than she saw at NIH. She saw people who were seen every day, which is a different spectrum than those who are selected to be enrolled in a study protocol at the NIH. [33:42] That broadened her viewpoint. It's maybe not all food-triggered. They were seeing adults who'd never had food allergies or asthma their whole life, and they had eosinophilic esophagitis suddenly as a 50-year-old. There's a significant group of them. [34:10] What Dr. Kuang learned and tries to be open-minded about is that where you train, what sorts of patients you see, really shape your viewpoint and thinking about the disease process and the management process. [34:24] Dr. Kuang says she was so lucky to have experienced that at a quaternary care referral center like the NIH and at an academic center like Northwestern, where there are fantastic gastroenterologists who see so many of these patients. [34:56] Dr. Kuang and an Allergy Fellow knew they were going to get a wonderful data set from the NIH patients they had recruited, so they thought they had better look deeply at what had been learned before with older technology, with mice and people. [35:13] They decided to gather previous research, and that ultimately got published as an article. From that research, they learned that people did things in many different ways because there was no standard. They didn't know what the standard should be. [35:28] Different things you do to try to get eosinophils out of tissue impact how they look, in terms of transcript, gene expression, and what messages they make to define themselves as an eosinophil. [35:43] They also learned that because eosinophils are hard to work with, they die easily, and you can't freeze them and work on them the next day; you can introduce issues in there that have to be accounted for. [35:59] They learned that as an eosinophil research community, they ought to come up with some standards so that they can compare future studies with each other. Dr. Kuang says it was impossible to compare the old studies that used different premises. [36:50] Dr. Kuang says we need to be proactive in creating the datasets in a standard way so that we can compare and have a more fruitful and diverse community of data. It's hard to use the old data. [37:57] Dr. Kuang says they get fresh blood from patients, and because eosinophils are finicky, they need to be analyzed within four hours, or preserved in a way to save whatever fragile molecules are to be studied. [38:19] If you let it sit, it starts dying, so you won't have as many of them, and they start changing because they're not in the body. Dr. Kuang experimented with putting a tube of blood on the bench and checking it with the same test every two hours. It changes. [38:38] Four hours is a standard to prevent the eosinophils from dying. Patients need treatment. If a patient is hospitalized and needs treatment, Dr. Kuang's team needs to be there to get a sample before treatment is started. [39:03] The treatment impacts it, changing the situation. Much of the treatment, initially, is steroids. When you give lots of steroids, the eosinophils go away. It's no good to draw their blood then. [39:27] Dr. Kuang also gets a urine sample. The granules of the eosinophils can get into the urine. As they study people with active disease, they want to capture granule proteins in the urine as a less invasive way to monitor activity in different disease states. [40:04] The patient just needs to give Dr. Kuang either arm and a urine sample. [41:04] Dr. Kuang explains, you can count your eosinophils after four hours, but to study them, they have different flags of different colors and shapes. Those colors and shapes may mean that it's an activated eosinophil, or they may have other meanings. [41:41] Dr. Kuang focused on markers that look at whether it's going to spill its granules and some traditional markers of activation. [41:50] Everyone chooses a different marker of activation. So they decided to look at as many as they could. One marker is not sufficient. They seem to be different in different conditions. The markers are on the surface; you need to analyze them right away. [42:20] Then, Dr. Kuang breaks open the eosinophils and grabs the messenger RNA. They preserve it to do sequencing to read out the orders to see what this eosinophil is telling itself to make. RNA chops up messages. [43:00] When you open an eosinophil, a protein you find is RNA, which chops up messages, destroying parts of the cell. You want to save the message. There's a brief time to analyze the eosinophil. Dr. Kuang works to preserve and read the message. [44:04] Dr. Kuang hopes someday to run a tube of blood, look at the flags on the eosinophils, and say, "I think your eosinophilic GI disease is active," or "You have a kind of eosinophilic GI disease we need to monitor more frequently for organ damage." [44:38] If another patient doesn't have those flags, Dr. Kuang could say, "I think the chances that you're going to have involvement elsewhere are low." That can give reassurance to folks who are worried. [45:15] Dr. Kuang hopes that someday we can understand better why some people have food allergies vs. eosinophilic GI disease. They both have T cells, but the T cells have different packages inside with messages to deliver. [45:34] Every day, Dr. Kuang has to tell patients she doesn't have that answer. Someday, she hopes she can tell a patient she does have that answer. [46:35] Dr. Kuang tells about an NIH grant she's excited about and the patients she recruits after therapy, or elimination diets, to examine eosinophils and T cells, to see the impacts their treatments or diets have had on eosinophilic GI disease. [47:18] Dr. Kuang believes there will be predictors of who will respond to an elimination diet and who will respond to steroid therapy. She hopes one day to have that, rather than going through rounds of six to eight weeks followed by a scope. [47:34] If you have an elimination diet for six to eight weeks, every time you add back a food, you have to do a scope. Dr. Kuang says it would be great if you could be more precise ahead of time for therapy. [47:48] Dr. Kuang says these wonderful drugs selectively take out parts of the pathway in the immune system. They provide real-life opportunities to ask, why is this important in human biology and the human immune system? [48:15] Dr. Kuang finds the knowledge itself fascinating and useful. She hopes it informs how we choose future drugs or therapeutic avenues to get the best we can out of what we've learned, so we have more targeted ways of treating specific diseases. [48:48] Ryan is grateful for all the research happening for the eosinophilic disease community and all the patients participating in the research. He asks Dr. Kuang how a patient can participate in research. [49:12] There are lots of ways to be involved in research. Dr. Kuang says her patients come away from participating in research feeling good about having done it. [49:22] Answer a survey, if that's what you have bandwidth for. Where therapies are changing, being a part of a community is good for the community, for the future, but it's good for you, too. It's healing in ways that are not steroids or biologics. [49:58] Being part of a community is healing in ways we all need when we feel alone and bewildered. You're not alone. [50:12] There are many ways to participate: APFED, CEGIR, individual institutions, and clinical trials. They all have different amounts of involvement. It's worthwhile to participate, not only for future patients but for yourself. They're fantastic! [50:56] Dr. Kuang talks about the privilege as a physician of working with APFED and other organizations to do this work. [51:09] Holly thanks Dr. Kuang for sharing all of this research and exciting information. [51:25] Dr. Kuang is excited about what her group is doing and is hopeful. Besides showing up for this disease, we have to show up for research, in general, in this country. It's a dark time for NIH research funding. [51:55] Dr. Kuang asks the young listeners who are thinking of choosing a field to see the potential and get into it, study this, and believe that there's going to be a future with a more nurturing research environment. [52:36] Dr. Kuang would hate to lose generations of scientists. She says that once she was a little girl who was trying to be a scientist. Her parents had no connections with scientists or doctors, but she was able to get into research, and she thinks you can, too. [53:48] As a graduate student, Ryan has always been interested in trying to improve things, and he sees hope on the horizon. He's very grateful to the APFED community for supporting these research HOPE Pilot Grants. [54:17] Ryan is very grateful to Dr. Kuang for joining us today. [54:22] For our listeners who want to learn more about eosinophilic disorders, we encourage you to visit apfed.org and check out the links in the show notes. [54:28] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at apfed.org/specialist. [54:37] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at apfed.org/connections. [54:57] Dr. Kuang thanks Ryan and Holly and says she enjoyed the conversation. Holly also thanks APFED's Education Partners GSK, Sanofi, Regeneron, and Takeda for supporting this episode. Mentioned in This Episode: Fei Li Kuang, MD, PhD, Allergist and Immunologist, Northwestern Medicine Grants and publications discussed: Apfed.org/blog/apfed-announces-2018-hope-apfed-hope-pilot-grant-recipient/ Apfed.org/blog/fei-li-kuang-hope-pilot-grant-award/ Pubmed.ncbi.nlm.nih.gov/39213186/ Pubmed.ncbi.nlm.nih.gov/37487654/ APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections apfed.org/research/clinical-trials Education Partners: This episode of APFED's podcast is brought to you thanks to the support of GSK, Sanofi, Regeneron, and Takeda. Tweetables: "I think the patients that you meet in a clinical trial, especially in a special place like NIH, occupy a space in your heart — I don't mean to be all too emotional about this — that makes you want to keep working on the subject area." — Fei Li Kuang, MD, PhD "When I was a Fellow at the NIH, we were doing a Phase 2 clinical trial, looking at, for want of a better word, "blowing up" eosinophils in patients who have a lot of them, hypereosinophilic syndrome patients." — Fei Li Kuang, MD, PhD "We're at a point where we've recruited a lot of people. I've had patients drive from the northern part of Illinois … come down and give me blood. It's amazing what people want to do and are willing to do. It's very humbling, actually." — Fei Li Kuang, MD, PhD "You erase the eosinophils from the picture, but that message is still coming. Who's carrying out the orders? Or is that message maintaining the wall of epithelial cells in a certain way that we didn't appreciate because the eosinophils were also there?" — Fei Li Kuang, MD, PhD "We need to be proactive in creating the datasets in a standard way so that we can compare and have a more fruitful and diverse community of data." — Fei Li Kuang, MD, PhD "I think it's worthwhile to participate [in a clinical trial], not only for the future people but for yourself." — Fei Li Kuang, MD, PhD Guest Bio: Fei Li Kuang, MD, PhD, is currently an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine in Chicago, IL. She is a graduate of the Albert Einstein College of Medicine Medical Scientist Training Program with both a PhD in Cell Biology/Immunology and an MD. She completed her Internal Medicine Residency at Columbia University, New York Presbyterian Hospital in New York City, she did her Fellowship in Allergy and Immunology at the National Institute of Allergy and Infectious Disease (NIAID) in Bethesda, Maryland. She is a physician-scientist who takes care of patients with eosinophilic disorders and also performs laboratory research on these disorders in her lab, often using patient samples.
National Nut Day (And Naked at the Allergist) by Maine's Coast 93.1
On this episode of Eczema Out Loud, Dr. Ari Zelig, an allergist and immunologist out of Charleston, South Carolina's Charleston ENT and Allergy, talks eczema, allergies, and the relationship between the two. We cover food allergies, environmental allergies and treatments. We also do some myth-busting and answer your community-sourced questions. What did you think of this episode? Consider writing us a review!National Eczema Association (NEA)NEA is the driving force for an eczema community fueled by knowledge, strengthened through collective action and propelled by the promise for a better future.https://nationaleczema.org/Contact us: podcast@nationaleczema.org
Summary In this truncated replay, Dr. Shyam Joshi explores the intersection between allergy and dermatology—focusing on how chronic spontaneous urticaria (CSU), atopic dermatitis, and food allergies often overlap. Learn how emerging biologics like omalizumab and dupilumab are reshaping treatment decisions, why comorbidities matter, and how collaboration between allergists and dermatologists creates better outcomes for patients with complex allergic and dermatologic conditions. This episode dives into real-world case studies, FDA updates on antihistamines, and the multidisciplinary approach to managing eczema and CSU in pediatric and adult populations. Takeaways - FDA Advisory on Antihistamines: Long-term use of cetirizine or levocetirizine can lead to rebound pruritus upon discontinuation—but gradual tapering minimizes symptoms. - Biologic Selection Depends on Comorbidities: - Omalizumab is effective for IgE-mediated food allergies and chronic urticaria. - Dupilumab is preferred for patients with eosinophilic esophagitis (EoE) or moderate-to-severe atopic dermatitis. - CSU Is Systemic: Symptoms may extend beyond hives—impacting joints, sleep, and energy levels. - Comorbid Conditions Are Common: Up to 20 % of CSU patients have asthma, allergic rhinitis, or food allergies; identifying these helps guide treatment and patient education. - Unified Messaging Builds Trust: Consistent communication from both dermatologists and allergists reduces unnecessary testing and supports adherence to treatment plans. Chapters 00:00 - Introduction: Bridging Allergy and Dermatology 00:45 - Case Study: An 18-Year-Old with Chronic Urticaria 02:00 - FDA Warning: Antihistamine Withdrawal Itch 03:45 - Selecting the Right Biologic: Food Allergy Considerations 04:45 - Eosinophilic Esophagitis and CSU 05:35 - The Systemic Nature of CSU 06:40 - Comorbidities in CSU and Atopic Patients 07:30 - Multidisciplinary Collaboration in Practice 08:00 - Closing Thoughts & Educational Disclaimer
From “colic” that never eased to four pages of confirmed allergens, Susanna Peace Lovell recounts the first years of parenting her daughter, Arizona—years marked by nonstop crying, full-body eczema, and relentless advocacy. When a hypoallergenic formula finally brought relief around 18–19 months, Susanna could breathe—and begin reframing motherhood with compassion for her child and herself. She shares practical allergy survival tips (from table toppers to EpiPens), how autism diagnosis informed self-advocacy, and why community through We Are Brave Together mattered. This conversation serves as a guidepost for any parent navigating complex medical needs while preserving joy at home. You won't want to miss Katie and Susanna's conversation. Episode Timestamps: [03:45] Signs of Severe Food Allergies in Infants – From nonstop crying to full-body eczema, Susanna shares the earliest symptoms Arizona showed. [08:15] How Doctors Diagnosed Multiple Severe Food Allergies – The long journey to four pages of allergy results and what that meant for daily life. [18:30] Switching to Hypoallergenic Formula – How finding the right formula finally brought relief after months of suffering. [22:45] Tips for Parents Navigating Severe Food Allergies – Compassion, picky eating strategies, and surviving dining out with kids. [26:50] Teaching Kids Self-Advocacy with Food Allergies – How Arizona learned to protect herself and why autism shaped that process. [30:40] Finding Support for Parents of Kids with Severe Allergies – The role of We Are Brave Together and community in surviving medical parenthood. Resources mentioned: We Are Brave Together (caregiver community Jessica Patay founded). Susanna's Website Follow Susanna on Instagram
Warner Carr, MD, Allergist and Immunologist at the Allergy and Asthma Associates of Southern California, discusses the mastocytosis control test and its implications for physicians.
In this special Pride episode, Mark-Eugene and Dylan team up with DPS/Broadway Licensing for an author roundtable celebrating queer voices in the theatre. Moderated by Emmy-winning journalist Patrick Pacheco, the conversation features an all-star panel: Charles Busch (The Tale of the Allergist's Wife, Vampire Lesbians of Sodom), C.A. Johnson (All the Natalie Portmans), Michael Korie (Grey Gardens, Flying Over Sunset), and Lisa Kron (Fun Home, 2.5 Minute Ride). Together, they reflect on the power of queer storytelling, the evolution of representation onstage, and what it means to write with pride. It's a dynamic, heartfelt discussion with some of the most influential and exciting voices in American theatre today. Learn more about your ad choices. Visit megaphone.fm/adchoices
Listen as Michael S. Blaiss, MD provides case-based perspectives on chronic cough recognition, burden, management, and pathophysiology and describes the evolving treatment landscape for refractory chronic cough.PresenterMichael S. Blaiss, MDClinical Professor of PediatricsDivision of Allergy-ImmunologyMedical College of Georgia at Augusta UniversityAugusta, GeorgiaLink to full program: https://bit.ly/4kweynG
How can you treat a chronic cough when you're not sure what's causing it? In this episode of BackTable ENT, Dr. Basil Kahwash, a board-certified allergist and immunologist from Ohio ENT and Allergy, discusses the complexities of diagnosing and treating chronic cough. ---SYNPOSISDr. Kahwash explains common causes, such as upper airway cough syndrome, allergic rhinitis, and asthma, and delves into the importance of patient history and physical exams in identifying the root cause. The conversation also covers diagnostic tools, including allergy testing, spirometry, and chest X-rays, as well as treatment options like allergy medication, immunotherapy, and cough suppressants. Dr. Kahwash also touches upon new therapies on the horizon and emphasizes the role of multidisciplinary collaboration with ENTs, pulmonologists, GI specialists, and speech therapists in managing chronic cough.---TIMESTAMPS00:00 - Introduction03:20 - Defining Chronic Cough06:47 - Patient Evaluation and Key Questions11:10 - Asthma vs. Allergic Rhinitis Cough18:31 - Red Flags in Chronic Cough30:20 - Diagnostic Testing for Chronic Cough34:46 - ENT Collaboration in Allergy36:08 - Skin Testing vs. Blood Testing for Allergies44:30 - Eosinophilic Esophagitis (EOE) & Upper Airway Cough Syndrome50:28 - Allergy Treatment Pathways01:03:05 - Conclusion and Contact Information---RESOURCESDr. Basil Kahwash https://www.ohioentandallergy.com/physicians/basil-kahwash-md/
Allergies are one of the most common—and nerve-wracking—concerns for families starting solids. From knowing when to introduce allergens to understanding how often they should be offered, it's no wonder so many parents feel overwhelmed.In this week's episode of Boob to Food The Podcast, we're joined by the brilliant (and relatable) Dr. Chaitanya Bodapati, a dual-trained paediatric allergist/immunologist and general paediatrician. Not only does she bring a wealth of clinical experience, but she also shares her perspective as a mum navigating food allergies firsthand.In this episode we discuss:When and how to start introducing allergensWhy timing matters (but also why you don't need to panic)How often allergens should be offered and in what quantityWhat to do if your baby spits the food out (again!)How to approach allergens when you have dietary restrictions or food avoidance in your familyWhether it's necessary to introduce every single tree nut individuallyWhat to do if your baby is unwell, or if there's a family history of allergyWhat reactions to look out for and when to seek help... and so much more!You can connect with Dr Chai via Instagram or through her website www.childrensallergyclinic.com.au.Today's episode is brought to you by Harris Farm. Harris Farm is a family-owned Aussie business and one of our favourite places to shop - both for everyday staples and those special little extras that make meals feel exciting and extra delicious. They're passionate about supporting local growers, reducing food waste, and making good food more accessible.If you're a fan of vibrant produce, pantry staples without the nasties, and delicious snacks your kids will actually eat (without the additives), Harris Farm is the place to go. We especially love their Imperfect Picks range (hello, sustainable savings!) and their Colour by Nature initiative that removes artificial colours from their products.Visit www.harrisfarm.com.au to find your nearest store.Follow us on instagram @boobtofood to stay up to date with all the podcast news, recipes and other content that we bring to help make meal times and family life easier.Visit www.boobtofood.com for blogs and resources, to book an appointment with one of our amazing practitioners and more.Presented by Luka McCabe and Kate HolmTo get in touch please email podcast@boobtofood.com
Description: Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Dr. John Accarino, an allergist and immunologist at Massachusetts General Hospital and Mass General for Children, on the topic of immunology support for eosinophilic esophagitis (EoE). Dr. Accarino shares his experiences as a person living with food allergies, allergic asthma, peanut allergy, and eosinophilic esophagitis. He tells how his experiences help him in his work with patients. Dr. Accarino shares some education on a variety of allergy mechanisms and the treatments that mitigate them. Disclaimer: The information provided in this podcast is designed to support, not replace the relationship that exists between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own. Key Takeaways: [:49] Co-host Ryan Piansky introduces the episode, brought to you thanks to the support of Education Partners Bristol Myers Squibb, GSK, Sanofi, and Regeneron. Ryan introduces co-host Holly Knotowicz. [1:14] Holly introduces today's topic, immunology support for eosinophilic esophagitis (EoE), and introduces today's guest, Dr. John Accarino, an allergist and immunologist at Massachusetts General Hospital. Holly welcomes Dr. Accarino to Real Talk. [1:49] Holly notes that Dr. Accarino is her allergist and immunologist. [2:03] Dr. Accarino works at Massachusetts General Hospital and Mass General for Children. Allergy and Immunology is a field where he can see pediatrics and adults. Originally trained in pediatrics, now Dr. Accarino sees patients of all ages. [2:23] Dr. Accarino grew up with allergies. He has experienced food allergies since he was young, along with allergic asthma, and some eczema, which he grew out of. Later in life, he was diagnosed with eosinophilic esophagitis. He talks with his patients about his experiences. [2:47] Dr. Accarino also does research on drug allergies in the context of certain drug interactions that involve eosinophils. [3:06] When Holly was referred to Dr. Accarino, it was for multiple sclerosis (MS). He told her, “It looks like you have EoE. I have EoE.” It was a huge relief to Holly not to have to explain EoE to her doctor. [3:41] Some patients start to explain their EoE to Dr. Accarino, and he assures them he understands where they're coming from. Sometimes, he has to be careful not to think everyone has his symptoms, as there is a large spectrum of presentations. [4:26] Dr. Accarino wasn't diagnosed with EoE until he was in his allergy fellowship, after he suspected it when he had a food impaction at a steakhouse at a graduation party from his pediatric residency. He tried to manage the EoE with lifestyle changes. [5:39] Dr. Accarino didn't often go to see a doctor during residency, but he realized it was probably a good time to get an endoscopy. [5:52] Holly shares how she was also diagnosed as a clinical fellow. She was subbing for someone on the GEDP team at Children's Hospital in Colorado. Listening to all the patients, she realized, “This sounds a little bit like me … What is going on?” [6:23] Even with his medical background, it took Dr. Accarino some time to decide to get the endoscopy and biopsies. You or your doctor have to have a high level of suspicion to realize this isn't just reflux. Food doesn't get stuck in every person's throat. [7:01] Thinking back, Dr. Accarino remembers an instance as a child when a dry muffin got stuck in his throat. He stayed calm and waited for it to pass. He thought it was normal. [7:39] He drank a lot of water and chewed his food a lot. Those are markers of potential esophageal inflammation. [8:20] Different groups have different management strategies for EoE. Dietary management, topical steroids, biologics. A subgroup of people with EoE are responsive to proton pump inhibitors (PPIs). Finding the best management strategy is a work in progress. [8:53] With pediatric patients, the parents control the diet, and the children eat what is prepared. He notes that with adult patients, sometimes they let foods slip through. [9:10] If you want to do a single-food elimination diet with dairy, there's a lot of dairy in the American diet. Dr. Accarino tried eliminating dairy and wheat, but he still had persistent eosinophils with dietary elimination. [9:24] Dr. Accarino then tried PPIs. To know if you have PPI-responsive EoE, you might do twice-daily omeprazole at a significant dose. Have the endoscopy after a few weeks pass and see if the eosinophils are still present in the biopsy. [9:59] Dr. Accarino did that recently and still has the eosinophils. He plans to talk to his gastroenterologist about considering dupilumab, but he feels that he can mitigate his subjective day-to-day experience of symptoms with dietary elimination and PPIs. [10:24] If you still have the presence of eosinophils on biopsy, there's still inflammation happening. In the long term, you still have to worry about fibrosis and narrowing. [10:34] The last treatment Dr. Accarino tried was as a research participant in a study for dissolvable fluticasone. He received either the medication or a placebo; he doesn't know which. [11:01] To stay in the study, he had to journal and report his symptoms regularly. He didn't have enough symptoms to stay in the study. They were looking for a baseline to see how it changed with either the placebo or the medication. [11:20] In research, you have to have a baseline to start, and then you want to see improvement, plus or minus. With EoE, it's difficult. You have the biopsy and eosinophils, but there's a large spectrum of symptoms that people may experience. [12:40] Holly appreciates Dr. Accarino's unique perspective as a doctor with EoE who has experienced various treatments and diets. He understands the concerns of his patients. [12:43] Dr. Accarino says even taking a twice-daily PPI or other medication is difficult for a lot of people, and that's the most simple of these therapies. [13:06] Dr. Accarino wants to validate everyone's experience in terms of how difficult it is to treat this disorder, how it may present in different ways, and how there may be a delay in diagnosis. [13:16] This isn't IgE-mediated immediate food allergy, where you eat a food and may have swelling within minutes; you may have flushing or hives. That's very clear. With EoE, it's a different mechanism; in many cases, there is a delay. [14:37] Allergy, in general, is under the purview of clinical immunology. Dr. Accarino is allergic to peanuts and has an IgE-mediated immediate reaction to them. If he eats a peanut, he has symptoms within minutes. He could have anaphylaxis. As a result, he carries an epinephrine auto-injector. [15:01] If Dr. Accarino has a skin test, it will be positive for peanut. He has IgE antibodies to peanuts. He also has oral allergy syndrome where the body mistakes certain fruits, vegetables, or nuts with certain tree pollens or grass pollens. [15:23] Oral allergy syndrome is usually a lower-risk condition where it's a less-stable protein that once cooked might not produce any symptoms. If it's raw when you consume it, you may have oral itching, a bit of throat discomfort, or tongue itching. [15:54] Your stomach acid breaks it down so it doesn't get into your bloodstream and you shouldn't have a systemic reaction. [16:01] If Dr. Accarino eats a peanut, his stomach acid doesn't break down the high-risk, stable peanut protein, it gets into his bloodstream, and he can have a systemic anaphylactic reaction. [16:20] Chronic EoE symptoms can present with something like a food impaction, or bad reflux or belly pain, and nausea. The reaction may not be immediate. It may be progressive over days or weeks. [16:38] FIRE is an interesting condition that takes some time to narrow down. It's an immediate response of the esophagus, but we don't think it's histamine-mediated. [16:56] We don't know, exactly, the mechanism but it's in people with eosinophilic esophagitis. They feel differently, and there would be different specific food triggers. [17:11] It took some time to figure out what was going on. Dr. Accarino felt like he had a lump in his throat, then a lump in his chest, nausea, and belly pain. It felt like a slow progression of EoE symptoms, and it was from specific food triggers, in his case. [17:30] In some of the FIRE literature, they looked at banana and avocado. For Dr. Accarino, it took a couple of exposures to protein bars and milk protein whey isolate, specific to protein bars he had multiple times, until he figured out that was the trigger. [17:50] Another protein whey isolate that Dr. Accarino scooped as a powder and made into a shake also led to FIRE. [17:55] It took that event for Dr. Accarino to figure out it wasn't just a flareup of EoE or reflux but some trigger that caused this response that wasn't anaphylaxis but may be due to the recruitment of eosinophils or some immediate process not well understood. [18:18] FIRE is going to be very hard to research. How would we figure this out? Would we bring someone in and do an endoscopy immediately and see what happens? There's a lot of descriptive data and case series. [18:32] Dr. Accarino has had experiences when he knew it wasn't an immediate anaphylactic reaction, oral allergy, or reflux. He asked what else it could be in the context of EoE. When he looked at different case series, that's the presentation he had. [19:17] Dr. Accarino acknowledges that having personal experience with FIRE, oral allergies, and IgE-mediated allergies, on top of EoE, has influenced his work as a medical professional. He can share anecdotes with patients as he explains the available testing. [19:39] Dr. Accarino says a lot of immunology and allergy is explaining the diagnostic tools and management strategies we have and what we think is going on. [19:50] The immune system is infinitely complex, and a lot of the practice is making a digestible analogy, not just in the context of allergic conditions but also everything with the immune system. There are so many cells doing so many different things. [20:04] Dr. Accarino explains false positives in testing. He has positive scratch tests for peanuts, cashews, and almonds, which shows he has IgE for each of them. He is allergic to peanuts, but he can eat cashews and almonds. Those are false positives. [20:56] When a scratch test is negative for immediate food allergy, it's a powerful predictive tool. But you may get false positives. How positive is it? There might be room for more discussion. [21:10] There may be more hesitation for people who do large panels of food testing without any history of reacting to any foods. [21:31] Some people have EoE triggered by milk or wheat but have negative skin tests. That doesn't mean they aren't triggered by these foods. The skin test is an IgE histamine mast cell mechanism, not for eosinophils, which are other immune cells. [21:58] We go down these steps of thinking about diagnostic triggers and eventually treatment for those immediate symptoms mentioned for EoE. [22:09] Dr. Accarino doesn't expect FIRE to be responsive to epinephrine. He doesn't have to stabilize the mast cells. It's a chronic disease that's flaring up. You treat it with a chronic type of treatment. [24:10] Dr. Accarino says that for a doctor, immunology is rewarding, interesting, and complex, but it's intimidating until you get your foothold and see patients and clinical experiences. [25:14] A lot of medical students and residents are a little fearful of immunology. They might not think about it too much. Dr. Accarino loves to talk about it and think about it. He can't think of anything more complex in terms of systems within our body. [25:37] Ryan comments on his experiences with IgE-mediated food allergies, some environmental allergies that he has no idea how they work, and EoE, which he believes he has a good grasp on. [25:55] Ryan imagines that having a physician with a good understanding of the immune system and also personal experience would be helpful for a patient with multiple allergic conditions. [26:13] Dr. Accarino sees a large overlap of seasonal or year-round environmental allergies and EoE. There are some studies that show that endoscopies on patients with EoE may change at different times of the year if they have underlying seasonal allergies. [26:33] Some people who have food allergies also have EoE or other eosinophilic disorders. Some discussions with them may be about blood tests that detect eosinophils in the bloodstream versus biopsies of the esophagus, stomach, or colon. [27:15] It's thinking about what tests are available, what they tell us, and how to use them to predict the next steps, things like dietary changes or for immediate food allergy, considering challenges versus full avoidance. Each test has its pluses and minuses. [27:35] People like a clear test, and they like an easy fix, but sometimes there's a lot of nuanced conversation of shared decision-making and trying things in a supervised setting. [27:57] Holly speaks as a patient of the investigative testing Dr. Acarino is doing with her immune system trying to figure it out along with her MS and EoE. [28:14] Dr. Accarino says the words immune system, immunity, and inflammation are used a lot in talking about foods. Dr. Accarino uses the framework of the immune system trying to help you. [28:42] Sometimes, instead of making helpful antibodies to things like vaccines or viruses, that give you protection, the immune system makes antibodies that attack a certain organ or your joints. [29:02] Dr. Accarino thinks of treatments that suppress the immune system in certain ways. Some treatments cool down the populations of many different immune cells. Oral steroids and prednisone are used for many conditions for autoimmune flares. [29:29] Oral steroids, in the long term, may lead to weight gain, bone density changes, and diabetes. The big push for many diseases is toward non-steroidal biologics to target specific cells that cause disease. [29:59] For Crohn's disease, a specific monoclonal antibody is used to target TNF-alpha molecules and blocks that inflammation pathway. [30:14] For EoE, dupilumab, a specifically designed antibody, blocks a specific receptor in a specific pathway so the immune system doesn't have to be shut down and the patient doesn't have the side effects of steroids. It's a targeted therapy. [30:32] What you see in commercials for injectable medications are large, designed antibodies that, if you took them in a pill form, your stomach acid would break down and digest. So they are injections and infusions that go directly into the bloodstream. [31:22] Medications that end in -mab are monoclonal antibodies. They are very large molecules that would not be stable in stomach acid. [32:09] Dr. Accarino talks of eosinophil normal function and aberrant function. IgE-mediated reactions are usually related to mast cells, a type of immune cell that shouldn't be in the bloodstream. [32:54] Dr. Accarino can do a CBC with differential to see the number of white blood cells and the number of red blood cells. The differential of white blood cells will include neutrophils, lymphocytes, and eosinophils. It shouldn't show mast cells. [33:19] If you have mast cells in your bloodstream, that's mastocytosis, a different problem. Mast cells live in your skin, in your gut, and around your blood vessels. They're full of granules like histamine and tryptase. [33:38] Dr. Accarino explains how mast cells release their contents and how he would treat the resulting swelling or itch with an antihistamine or epinephrine. Epinephrine treats systemic reactions and stabilizes the mast cells. [34:16] Mast cells have many receptors and may be triggered by many things other than IgE. This is a conversation Dr. Accarino has with patients who have chronic hives unrelated to any foods. [34:29] Some people get hives from non-steroidal anti-inflammatory drugs NSAIDs. Some get hives from vancomycin. Some get hives when the temperature changes, from tight clothing, or from IV contrast. It's not an IgE-mediated mechanism, but it's still mast cells being degranulated. [35:45] Dr. Accarino says people see hives and they think allergy. But, like EoE, it doesn't involve histamine. There can be hives that aren't related to allergies. This can be idiopathic urticaria or spontaneous urticaria. [36:04] Sometimes, when switching from a day shift to a night shift, hormonal changes will trigger hives. Sometimes, the stress of having a family member in the hospital will cause hives. An accumulation of triggers can lead to mast cell degranulation. [36:38] There are many ways that allergy can have different mechanisms and treatments, with different cells involved. There are different molecules that cause symptoms and manifestations. [36:50] Navigating that and understanding what might be going on can give people a sense of reassurance. The biggest fear is a life-threatening allergic reaction. People will read about fatal anaphylaxis and wonder if it will happen to them with their condition. [37:16] Sometimes, thinking of the cells involved and the pathways may give a level of reassurance that this may not be the same thing that they read about. [37:28] Ryan thanks Dr. Accarino for joining us today. [37:37] Dr. Accarino says it was nice to reflect on things and to go through different scenarios and experiences he has gone through. It was nice to have the opportunity to share them with Ryan, Holly, and all the listeners. [37:57] For our listeners who would like to learn more about eosinophilic disorders, including EoE, please visit APFED.org and check out the links in the show notes. [38:06] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at APFED.org/specialist. [38:15] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at APFED.org/connections. [38:25] Ryan thanks Dr. Accarino for joining us today for this fun conversation. Holly also thanks APFED's Education Partners Bristol Myers Squibb, GSK, Sanofi, and Regeneron for supporting this episode. Mentioned in This Episode: Dr. John Accarino, MD, Allergist and Immunologist at Massachusetts General Hospital and Mass General for Children Episode 034: Food-Induced Response and Eosinophilic Esophagitis APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections Education Partners: This episode of APFED's podcast is brought to you thanks to the support of Bristol Myers Squibb, GSK, Sanofi, and Regeneron. Tweetables: “Allergy and immunology is a field where I can see pediatrics and adults. I was originally trained in pediatrics, but now I see all ages, from infants up until older adults.” — Dr. John Accarino “Part of the conversation sometimes is trying not to overly bias myself, where I say, ‘Oh, this is my experience.' … Like many diseases, there's a large spectrum of presentations, … different symptoms that people have.” — Dr. John Accarino “We don't think [Food-Induced Response in Eosinophilic Esophagitis is] histamine-mediated. We don't know exactly the mechanism, but it's in people with eosinophilic esophagitis. They feel differently, and there would be different specific food triggers. It took some time to figure out that was going on.” — Dr. John Accarino “When a scratch test is negative for immediate food allergy, it's a very powerful predictive tool. But there are times that you may get false positives. How positive is it? There might be room for more discussion.” — Dr. John Accarino “There are a lot of ways that allergy can have different mechanisms and different treatments, with different cells involved.” — Dr. John Accarino
Konstrakta - Serbia 2022 (22:33), Charles Busch - Tale of the Allergist's Wife (43:42) In our Season 2 premiere we're tackling Eurovision and the Avant-Garde! First, we deep dive into the history of avant-garde Eurovision acts and discuss the tension between Eurovision's desire to appeal to the broadest possible audience and its elevation of some of the most aesthetically and politically innovative pop acts of the last half century. Then, we talk to Eurovision avant-garde darling Konstrakta, who took Turin by storm in 2022 with In Corpore Sano. Konstrakta walks us through her decades long career, where she has explored a modernity shaped by listlessness, spiritual consumerism and consternation about how it is that Megan Markle actually does get her healthy hair. Finally, we sit down with queer theater pioneer Charles Busch, whose play, Tale of the Allergist's Wife, is the longest running Broadway comedy in the last quarter century. We get his thoughts on Eurovision's most boundary pushing acts, as well as a wild story about an alluring, antique thieving count. "VAMPIRE LESBIANS OF EUROVISION" CLIPS Konstrakta, In Corpore Sano (Serbia, 2022) -https://www.youtube.com/watch?v=odFhYxoXiuo Rodolfo Chikilicuatre, Baila el Chiki-Chiki (Spain, 2008) - https://www.youtube.com/watch?v=wfeCIvOxXBo Guildo Horn, Guildo Hat Euch Lieb (Germany, 1998) - https://www.youtube.com/watch?v=jo_DyXn-9Bc Les Fatals Picards, L'amour à la française (France, 2008) - https://www.youtube.com/watch?v=xjo3PIABpVQ Let 3, Mamma SC (Croatia, 2023) - https://www.youtube.com/watch?v=isZ_4AnCTnA&t=1s Verka Serduchka, Dancing Lasha Tumbai (Ukraine, 2007) - https://www.youtube.com/watch?v=hfjHJneVonE&t=1s
Can you slow down the atopic march and prevent kids from developing more allergic diseases? Type 2 inflammation plays a central role in allergic diseases, which impact children from infancy through adulthood. From eczema and asthma to food allergies and allergic rhinitis, these conditions are all connected through an underlying immune response: Type 2 inflammation. But is there a way to prevent the progression of these diseases? In this episode, Dr. Payel Gupta and Kortney are joined by Dr. Priya Bansal to explore how Type 2 inflammation manifests in children, the concept of the atopic march, and whether treatments like immunotherapy or biologics can alter the course of the diseases. Many parents aren't aware of the atopic march until their child starts developing multiple allergic conditions. Understanding how Type 2 inflammation progresses and when to intervene can be crucial in managing these diseases early. Dr. Bansal shares her expert insights on the best time to seek treatment and how biologics may help some children break the cycle of inflammation. What we cover in our episode about type 2 inflammation in children Understanding Type 2 Inflammation in Children: Understand type 2 inflammation's role in conditions like eczema, asthma, allergic rhinitis, and food allergies. Learn why children with one allergic condition often develop others over time. The Atopic March: Discover why some children with eczema go on to develop asthma and food allergies. Learn why early intervention can make a difference. Immunotherapy and Biologics: Can They Change the Course of Disease? Understand how allergy shots, OIT, SLIT and biologics work, when they are recommended, and whether they can stop or slow down the atopic march in children. When to See an Allergist & Parental Concerns About Treatment: Learn the signs that indicate your child may need an allergist evaluation. Plus, we address common concerns about aggressive treatment options, including steroids and biologics. Managing Type 2 Conditions at Home & School: Practical tips for parents navigating food allergic diseases. Made in partnership with The Allergy & Asthma Network. Thanks to Sanofi and Regeneron for sponsoring today's episode. This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.
We're celebrating 100 episodes and six years of The Itch Podcast! In this special episode, Dr. Payel Gupta and Kortney reflect on their journey—sharing insights from their experiences as a doctor-patient duo. Dr. G talks about how the podcast has influenced her as a provider, while Kortney shares how it has literally changed her life. We also introduce The Journal Club, a brand-new series in which we unpack the latest journal articles in our famous, easy-to-digest style. What We Cover in This Episode: Why Kortney decided to share her story about allergies, asthma, and eczema. Why Dr. Gupta became an allergist and how her personal journey shaped her career. The impact of patient advocacy—why Dr. G is passionate about empowering patients. The Itch Podcast's partnership with Allergy & Asthma Network and how it's raising awareness and education. Lessons from six years of podcasting—what we've learned from our guests, experts, and YOU, our listeners. Introducing The Journal Club—a new series unpacking medical research in a simple and relatable way.
Send us a textJoin Pulmonologist Dr. Mitchell Rothstein and Allergist and Immunologist Dr. Steve Dorman as they explore the violent activity that can project particles at 100 miles an hour out of your mouth: coughing! The doctors explain the varied approaches doctors take when trying to find the cause of a cough and what happens inside the body to turn a cough from productive to chronic. They explore things that can stimulate a coughing event and review what medications are currently approved for chronic cough. Finally, the two doctors discuss the possibility of new medications being developed currently in clinical trials. Stay tuned and don't miss this episode.Be a part of advancing science by participating in clinical research.Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.comListen on SpotifyListen on AppleWatch on YouTubeShare with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInWant to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.comMusic: Storyblocks - Corporate InspiredThank you for listening!
Off the back of news that Disney influencer Dominique Brown had died after consuming peanuts, a food she's allergic to, we've been curious about peanut allergies. What's its really like to navigate life with a peanut allergy or anaphylaxis? Today we hear about that experience first hand, plus what we should know about the allergy broadly. THE END BITS Support independent women's media Check out The Quicky Instagram here Feeling festive? Gift a Mamamia subscription! Head here to give the best stuff for women. GET IN TOUCH Share your story, feedback, or dilemma! Send us a voice note or email us at thequicky@mamamia.com.au CREDITS Host: Claire Murphy With thanks to: Charlie Begg, Mamamia's Audience Editor Dr Kahn Preece, Allergist and Deputy Chair of the ASCIA Paediatric Practice Committee Executive Producer: Taylah Strano Audio Producers: Tegan Sadler Become a Mamamia subscriber: https://www.mamamia.com.au/subscribeSee omnystudio.com/listener for privacy information.
Dr. Timothy Buckey, MD, MBE, discusses how medical ethics impact every patient encounter and offers practical advice on how to implement into clinical practice. (November 13, 2024)
Food Allergy Made Easy | Food Allergy Safety Based On Experience and Research
Hey Food Allergy Mama, I used to dread the regular blood tests that our Allergist would request at our food allergy follow-ups. Scared kids, watching my child go through pain, and all the crying and consoling. They seemed to cause so much stress for my kids and it was a struggle every time. I mean it's just something they had to do, but I always wondered if there was a way to make it easier. Honestly, it wasn't until my girls were MUCH older that I realized there are steps you can take to make the process of a blood draw or blood test easier. Even though I can't turn back time and make things easier for my kids, I can help you! So if you have an allergy blood test in your future, don't miss this episode, I'm cheering for you! Corinna NEXT STEPS: Subscribe to this podcast, and give it a review. Your review makes the podcast easier to find for families that need it. Join the Get Over The Fear of Trying New Foods Workshop. Grab the School Food Allergy Template & School Success Pack Grab the 90-Minute Variety Booster. Join the Dining Out With Food Allergies Workshop Join the Food Allergy Travel Workshop Grab the Social Event Survival Pack Get the free resources: Newly Diagnosed Checklist: https://www.friendlypantry.com/newly-diagnosed-with-food-allergies-guide Food Allergy Kids Empowerment Guide(for kids aged 2-7): https://www.friendlypantry.com/fa-kids-empowerment-guide Read The Blog: How To Calm A Child For An Allergy Blood Test Listen to Related Episodes: 33| Birthday Parties With Allergies: Educating Hosts Without Awkwardness 30| 3 Tips To Make Oral Food Challenges Less Stressful 19| Kindergarten Readiness: A Food Allergy Parent's Essential Guide 13| What I Wish I Knew Sooner About Living With Food Allergies
In episode 17, Mark-Eugene and David pass the mic to the incredible playwright and friend Nora Brigid Monahan who interviews the legendary Charles Busch! As the Tony Award-nominated writer behind "The Tale of the Allergist's Wife" and the long-running hit "Vampire Lesbians of Sodom," and a Sundance Festival award winner, Charles Busch has carved a unique place in the entertainment realm as a playwright, LGBT icon, drag actor, director, and cabaret performer. Charles dives into his journey from losing his mother at a young age to becoming an LGBT trailblazer. He shares hilarious and heartfelt stories about his career, including encounters with stars like Joan Rivers, Angela Lansbury, and Rosie O'Donnell. Afterward, David and Mark-Eugene chat about a slew of upcoming events from Drama After Dark- a cabaret featuring staff of the Drama Book Shop, David's multi hyphenated participation in an upcoming theatre festival, Mark's upcoming production of Goat Blood, and the next big events at the Drama Book Shop. Learn more about your ad choices. Visit megaphone.fm/adchoices
On this episode of Food Allergy Talk, I welcome Meg Nohe of Allergy Amulet. Meg has a child with peanut and tree nut allergies and she manages her own intolerances to dairy, gluten and citrus. She has been a team member at Allergy Amulet for almost 8 years, and is a Certified AllerCoach – she used to own a food allergy and intolerance coaching business where she trained commercial kitchens, restaurants, schools, and individuals on food allergy best practices. More about Meg:Meg is the Chief Operating Officer at Amulet. She has nearly two decades of experience positioning and launching consumer products, therapeutics, and medical devices—including multiple first-of-its-kind devices. She also spent several years in clinical sales at Pfizer and Stryker.Meg is the former President of Food Allergy Partners, a food allergy and intolerance consulting practice. She has a daughter with peanut and tree nut allergies, and she herself has intolerances to gluten, dairy, and citrus.Allergy Amulet Links:Video for how to run a testOur site! Link to sign up for our waitlistCheck out our FAQ'sOur IG handle: @allergyamulet Find us on Facebook!Join My Private Facebook Group to connect, support and share: https://www.facebook.com/groups/FoodAllergyPI/Read My Articles on WebMD: https://blogs.webmd.com/food-allergies/lisa-horneThe Everything Nut Allergy Cookbook: https://www.simonandschuster.com/authors/Lisa-Horne/190009636The Food Allergy Talk Podcast: https://foodallergypi.com/the-food-allergy-talk-podcast/Food Allergy P.I. Blog: https://foodallergypi.comX: @foodallergypi & @fatalkpodcastInstagram: https://www.instagram.com/foodallergypi/ and https://www.instagram.com/foodallergytalk/ TikTok: https://www.tiktok.com/@foodallergypiEmail: foodallergypi@gmail.com
Kristin is joined by Professor Sanjay Swaminathan to talk all things MABs or monoclonal antibodies. Dr Sanjay Swaminathan is a Clinical Immunologist and Allergist, he is a Senior Staff Specialist and Head of the Department of Immunology and Allergy at Westmead and Blacktown Hospitals.
Food Allergy Made Easy | Food Allergy Safety Based On Experience and Research
Hey food allergy mama, I know you might be looking for food allergy treatment that will help your child live a normal life of "food freedom". In this episode, I'm sharing the good, the bad and the ugly of our OIT journey. I hope it gives you a balanced look at what it's like to do Oral Immunotherapy so you can decide if it's right for your child and family. Of course, nobody's journey will be the same, and I'm not a doctor so please check with your Allergist for the food allergy treatment plan specific to your child. I'm cheering for you, Corinna Next Steps: 1. Subscribe to this podcast, and give it a review. Your review makes the podcast easier to find for families that need it. 2. Enroll in the Food Allergy Travel Workshop Enroll in the Get Over The Fear of Trying New Foods Workshop. Grab the School Food Allergy Template & School Success Pack Grab the 90-Minute Variety Booster. Enroll in the Dining Out With Food Allergies Workshop Grab the Birthday Party (and Playdate) Success Pack. Enroll in Calm Epinephrine Workshop. Enroll in Get Others To Take Food Allergies Seriously Workshop 4. Get the free resources: Newly Diagnosed Checklist: https://www.friendlypantry.com/newly-diagnosed-with-food-allergies-guide Food Allergy Kids Empowerment Guide(for kids aged 2-7): https://www.friendlypantry.com/fa-kids-empowerment-guide 5. Read The Blog: Food Allergy Treatment: Our Tree Nut Desensitization Journey 6. Listen to Related Episodes: Episode #1: From Mistakes to Food Allergy Awareness: Our Journey Episode #2: 7 Food Allergy Myths & Errors I've Made, And What To Do Instead Episode #13: What I Wish I Knew Sooner About Living With Food Allergies Episode #14: To Food Allergy Moms With Love 7. Resources mentioned in this episode: The Nervous Parent's Guide To Oral Food Challenges at Home
David Leopold interviews actor, writer, cabaret performer, and drag legend Charles Busch on his vivid career and his work on the online exhibition Hirschfeld's Drag Show, celebrating 74 years of performers in drag across 15 drawings by Al Hirschfeld. Hirschfeld's Drag Show is available to view now at alhirschfeldfoundation.org/exhibitions Recorded at The Algonquin Hotel in New York. Check out The Hirschfeld Package at The Algonquin Hotel Visit CharlesBusch.com Follow along with the show notes to view the works mentioned in the episode: Charles Busch (Two Drawings) Charles Ludlam, 1983 Jose Ferrer Charley's Aunt, 1940 Charley's Aunt (Other Drawings) Mary Martin as Peter Pan, 1954 Peter Pan (Other Drawings) Some Like It Hot, 1959 Myra Breckinridge, 1969 La Cage Aux Folles, 1983 Charles Busch in Vampire Lesbians of Sodom, 1986 Goodbye Charlie, 1959 Liza Minnelli Barbra Streisand Meghan Robinson in Psycho Beach Party, 1987 Andy Halliday in The Lady in Question, 1989 The Tale of the Allergist's Wife, 2002 Lynne Meadow, 1993 Victor/Victoria, 1995 Julie Andrews Valerie Harper Hairspray, 2002 Visit our website Visit our shop Like us on Facebook Subscribe to our Youtube Channel Watch Hirschfeld Moments: Ep.4 - Hirschfeld Draws a Star! Follow us on Twitter Follow us on Instagram HirschfeldHomestyle.com The Hirschfeld Package at The Algonquin Hotel
Dr Zachary Rubin joins the Glaucomfleckens to talk about how more people these days have allergies, what the Lone Star Tick is, details the first medication to treat allergies, and how he got into hula hooping along with the origin of his bow ties. — Want to Learn About Dr. Zachary Rubin: Tik Tok / Instagram / YouTube: @rubin_allergy — To Get Tickets to Wife & Death: You can visit Glaucomflecken.com/live We want to hear YOUR stories (and medical puns)! Shoot us an email and say hi! knockknockhi@human-content.com Can't get enough of us? Shucks. You can support the show on Patreon for early episode access, exclusive bonus shows, livestream hangouts, and much more! – http://www.patreon.com/glaucomflecken -- A friendly reminder from the G's and Tarsus: If you want to learn more about Demodex Blepharitis, making an appointment with your eye doctor for an eyelid exam can help you know for sure. Visit http://www.EyelidCheck.com for more information. This episode is brought to you by pRxcision. To see a demo, Go to http://www.prxcision.com/kkh. Today's episode is brought to you by the Nuance Dragon Ambient Experience (DAX). It's like having a virtual Jonathan in your pocket. If you would like to learn more about DAX Copilot check out http://nuance.com/discoverDAX and ask your provider for the DAX Copilot experience. Produced by Human Content Learn more about your ad choices. Visit megaphone.fm/adchoices
According to the Centers For Disease Control, about one in four Americans report they suffer from seasonal allergies. And if you're one of those unlucky folks, you may feel like your symptoms are getting worse. That's because more pollen is in the air than in past years. Allergist and spokesperson for the American College of Allergy, Asthma, and Immunology, Dr. Tania Elliot recently joined FOX News Rundown host Chris Foster to discuss this unfortunate trend and why you may be feeling so crummy. Dr. Elliot shared ways people can manage their symptoms with new treatments and explained why spring allergies are starting much earlier than in prior years. She also addressed some misconceptions about allergies including how certain foods and our diets impact our tolerance to allergens. The segment that aired this week on the regular weekday version of the Rundown only included a small portion of the interview. On the FOX News Rundown Extra, you will hear our entire interview with allergy expert Dr. Tania Elliot and hear even more of her advice on how to deal with allergy season. Learn more about your ad choices. Visit megaphone.fm/adchoices
According to the Centers For Disease Control, about one in four Americans report they suffer from seasonal allergies. And if you're one of those unlucky folks, you may feel like your symptoms are getting worse. That's because more pollen is in the air than in past years. Allergist and spokesperson for the American College of Allergy, Asthma, and Immunology, Dr. Tania Elliot recently joined FOX News Rundown host Chris Foster to discuss this unfortunate trend and why you may be feeling so crummy. Dr. Elliot shared ways people can manage their symptoms with new treatments and explained why spring allergies are starting much earlier than in prior years. She also addressed some misconceptions about allergies including how certain foods and our diets impact our tolerance to allergens. The segment that aired this week on the regular weekday version of the Rundown only included a small portion of the interview. On the FOX News Rundown Extra, you will hear our entire interview with allergy expert Dr. Tania Elliot and hear even more of her advice on how to deal with allergy season. Learn more about your ad choices. Visit megaphone.fm/adchoices
Weeks-long protests continue on some college campuses, even after many administrations worked to remove encampments set up by anti-Israel protesters. House Republicans have begun a probe investigating federal funding to universities amid the strife. Congressman Mike Lawler (R-NY-17) joins the Rundown to discuss the passage of the Antisemitism Awareness Act, the need to investigate the funding of the anti-Israel protests and weighs in on Congresswoman Marjorie Taylor Greene's attempt to vacate House Speaker Mike Johnson. According to the Centers For Disease Control, about one in four Americans report they suffer from seasonal allergies. And if you're one of those unlucky folks, you may feel like your symptoms are getting worse. That's because there is more pollen in the air than in past years. Allergist and spokesperson for the American College of Allergy, Asthma, and Immunology, Dr. Tania Elliot joins the Rundown to share ways people can manage their symptoms with new treatments and explain why spring allergies are starting much earlier than prior years. Plus, commentary from former Hawaii Congresswoman Tulsi Gabbard. (Image Via AP) Learn more about your ad choices. Visit megaphone.fm/adchoices
Weeks-long protests continue on some college campuses, even after many administrations worked to remove encampments set up by anti-Israel protesters. House Republicans have begun a probe investigating federal funding to universities amid the strife. Congressman Mike Lawler (R-NY-17) joins the Rundown to discuss the passage of the Antisemitism Awareness Act, the need to investigate the funding of the anti-Israel protests and weighs in on Congresswoman Marjorie Taylor Greene's attempt to vacate House Speaker Mike Johnson. According to the Centers For Disease Control, about one in four Americans report they suffer from seasonal allergies. And if you're one of those unlucky folks, you may feel like your symptoms are getting worse. That's because there is more pollen in the air than in past years. Allergist and spokesperson for the American College of Allergy, Asthma, and Immunology, Dr. Tania Elliot joins the Rundown to share ways people can manage their symptoms with new treatments and explain why spring allergies are starting much earlier than prior years. Plus, commentary from former Hawaii Congresswoman Tulsi Gabbard. (Image Via AP) Learn more about your ad choices. Visit megaphone.fm/adchoices
This episode covers:In this episode, we discuss why allergies occur, how to best manage allergies, why a customized nasal spray may be beneficial for your allergies, and so much more.Shuba Iyengar is a practicing Allergist and former academic researcher who is now founder and Chief Medical Officer at Allermi. She is passionate about making allergy care more accessible, affordable, and effective. She and her team have pioneered customized medications for allergy sufferers; offering relief to thousands of patients and improving their quality of life. Shuba graduated from UC Berkeley, Shuba completed medical school at Duke University, earning her MPH in tandem at UNC. After a research fellowship at the NIH, Shuba completed her residency at Stanford, then fellowship in allergy-immunology at Boston Childrens/Harvard. Shuba returned to the Bay Area to join Dr. Bocian at a large multi-speciality health system where she helped lead an allergy practice.Links mentioned during this episode:Allermi Website: https://www.allermi.comLyons' Share Instagram: www.instagram.com/thelyonsshareJoin Megan's Newsletter: www.thelyonsshare.org/newsletter
In today's show, we welcome Colonel Joseph Forester, a retired Air Force veteran and allergist, to discuss allergies and DoDMERB disqualifications. Service Academy and ROTC scholarship candidates must be DoDMERB qualified (or waived) in order to participate in these programs. One of the most common medical issues we see in candidates is an allergy to food. You can read the Department of Defense Instruction 6130.03 (or DoDI6130.03) here: https://www.gainserviceacademyadmission.com/wp-content/uploads/2024/01/613003_vol1.pdf We also discuss the DoDMERB waiver process more in depth in this episode: https://www.youtube.com/watch?v=qS3T6kVyLqQ&
Have you ever wondered why your doctor puts their membership in their bios? Why is it relevant to a patient that your allergist is a member of the ACAAI? This podcast is made possible through Allergy & Asthma Network's partnership with the American College of Allergy, Asthma and Immunology. Dr. G and Kortney had the special privilege of interviewing Dr. Gailen Marshall, the president of the American College of Allergy, Asthma, and Immunology (ACAAI). He explains what the ACAAI, also known as the College, does and why this matters to patients. We learn about the resources provided by the College, which offer patients invaluable support in managing their allergies. From accessing specialized care through the "Find an Allergist" tool to engaging with the ACAAI's educational materials and advocacy opportunities, patients are empowered to take control of their treatment journey. We also dive into Dr. Gailen Marshall's work in psychoneuroimmunology, which sheds light on how both external and internal environments impact allergic reactions. We touch upon Dr. Marshall's Presidential Initiative, CAAPER, which bridges the gap between community and academic allergists, driving innovation in patient treatment. As allergy research continues to advance, Dr. Marshall's leadership underscores the importance of interdisciplinary collaboration and patient-centred care in navigating the complexities of allergic diseases. What we cover in the episode Dr. Marshall's field of study: Psychoneuroimmunology What does the American College of Allergy Asthma and Immunology (ACAAI) do? How is the ACAAI relevant to patients? How can a patient take advantage of the resources the ACAAI has? How can patients be involved with the ACAAI? Why should you see an allergist? Dr. Marshall's Presidential Initiative - Community and Academic Allergist Partnership in Education and Research (CAAPER) About our guest, Dr. Marshall Gailen D. Marshall, Jr. MD, PhD, FACP, is the president of the American College of Allergy, Asthma and Immunology and holds distinguished roles as Chair of Allergy and Immunology, Professor of Medicine and Pediatrics, Vice Chair for Research, Director of the Division of Clinical Immunology and Allergy, and Chief of the Laboratory of Behavioral Immunology Research at the University of Mississippi Medical Center in Jackson. With a background in both Immunology and Medicine from the University of Texas Medical Branch in Galveston and extensive training at institutions like the University of Iowa and the University of Tennessee at Memphis, Dr. Marshall is renowned for his expertise in integrative approaches to managing inflammatory diseases. His research delves into the impact of psychological stress and environmental factors on immune responses, aiming to identify biomarkers for stress susceptibility. With over 200 publications and active engagement as a speaker in regional, national, and international forums, Dr. Marshall also served as Editor-in-chief of the Annals of Allergy, Asthma and Immunology, showcasing his leadership in the field. Additionally, he plays a vital role in professional societies like the Southern Society for Clinical Investigation, where he serves as Secretary-Treasurer and contributes to various committees, highlighting his commitment to advancing clinical research and education.
Character actor extraordinaire, Richard Kind, talks about having the authenticity and self confidence to speak his mind and get away with it. He says having a healthy ego and approaching the world with joy give him permission to say just about anything. And how that confidence goes into his landing acting jobs and parenting his children. We also talk about the loss of Matthew Perry and the horror of eating dinner by yourself. Bio: Richard Kind, a Drama Desk Award winner and Tony nominee for the Broadway hit The Big Knife, is an accomplished stage, screen and television actor who continues to redefine the term character actor. Kind starred as Sam Meyers in Red Oaks, and as Arthur in the Coen Brothers, A Serious Man. He appeared in the Best Picture Academy Award-winning Argo. Additional film credits include The Visitor and The Station Agent, among many others, as well as voicing characters in A Bug's Life and Cars. In television, besides his infamous roles on Spin City, Mad About You, and Curb Your Enthusiasm. Kind starred in the acclaimed HBO drama series Luck and Gotham. On stage, Kind has starred in the smash hit Broadway musical The Producers, The Tale of the Allergist's Wife, Candide, and Bounce, among others. Kind started his career in Chicago with the Practical Theatre Company, founded by Julia Louis-Dreyfus, Brad Hill and Gary Kroeger. Then moved on to Second City and the rest… is history.From Straw Hut Media
This week, Rosie's guest is the award winning playwright, actress and drag legend, Charles Busch. One of the funniest broadway shows Rosie ever saw was Charles' The Tale of The Allergist's Wife and when deciding to produce Taboo on Broadway, he was THE only writer she wanted! This pursuit and production began their lifelong friendship filled with drama, laughter, and survival. Join us as Rosie and Charles sit down to a long overdue chinwag about his fantastically fun and poignant new memoir, Leading Lady; finally embracing their experiences of Taboo; each of their ignored heart attacks; and the undeniable moments when magical thinking somehow appears at life's darkest and most needed moments. Please send voice memos with your questions, comments or thoughts to OnwardRosie@gmail.comSee omnystudio.com/listener for privacy information.
A lot of people think they have allergy to medications when they don't. In this episode, I welcome Allergist and Immunologist Farah Khan to chat about drug allergies and share some misconceptions. We discuss:What a true drug allergy looks likeWhy not all rashes while on antibiotics are a drug allergyAre true drug allergies hereditary?What to do if you truly feel your child has a drug allergyConnect with Farah Khan on Instagram @farah.khan.md
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