Podcasts about antithrombotics

DCS 1403: Antithrombotics

Get rid of those clots around anticoagulation and antiplatelet management Join us for a review of the perioperative risk assessment of bleeding and clotting and how to manage each patient's own antithrombotics. We are joined by Dr. Poorvi Hardman from Ohio State University.  Claim CME for this episode at curbsiders.vcuhealth.org! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Show Segments Intro Rapid Fire Questions/Picks of the Week Case 1 Risk stratification of thromboembolism and bleeding Review of types of surgeries and risk associated with surgical intervention Utilizing scoring systems to aid decision making Bridging Considerations for VKAs, DOACs  Pitfalls to bridging Case 2 Aspirin Management P2Y12 Management Consultants Outro Credits Written, produced and show notes by: Jaimie Patel MD Infographic and Cover Art by: Caroline Coleman MD Hosts: Monee Amin MD; Meredith Trubitt MD   Reviewer: Fatima Syed MD Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Poorvi Hardman MD Sponsor: Freed You can try Freed for free right now by going to freed.ai. And listeners of Curbsiders can use code CURB50 for $50 off their first month. Sponsor: Allbirds Get your shoes at Allbirds.com and use code CURB and score a free pair of socks with purchase today. Sponsor: Pathway Improve your clinical decision-making process and enhance patient care. Download the Pathway app today by visiting pathway.md

In which we talk about management of intermediate chest pain (including Cardiac CT Angiography vs Invasive Coronary Angiography, as well as Functional Stress testing), and review CKC pulmonary topics involving IDSA guidelines for Community Aquired Pneumonia treatment and Antithrombotics in VTE. | 00:00 Intro | | 00:38 TOC | | 01:18 CT vs ICA in intermediate chest pain (NEJM 2021) | | 02:59 TWDFNR - functional testing vs CCTA (JHM 2023, ACC 2022) | | 04:50 CAP review (IDSA 2019) | | 07:42 Antithrombotic therapy in VTE (Chest 2021) | | 11:22 Closing | [The appearance of external hyperlinks does not constitute endorsements by UCSF of the linked websites, or the information, products, or services contained therein. UCSF does not exercise any editorial control over the information found therein, nor does UCSF make any representation of their accuracy or completeness. All information contained in this episode are the opinions of the respective speakers and not necessarily the views their respective institutions or UCSF, and is only provided for information purposes, not to diagnose or treat.] Review content summarized by UCSF DHM CKC. Music by Amit Apte. Icon Vectors by Vecteezy.

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: May 31, 2018 Unfortunately, stroke is all too common. Nearly 1 million new strokes are diagnosed in the United States each year. And this means that complications of stroke--even if rare--may also be common. One such complication is hemorrhagic transformation. This week, Dr. Ava Liberman reviews a clinical case of hemorrhage following ischemic stroke. Produced by James E Siegler. Music by Ghost, Kevin McLeod, and Scott Holmes. Voiceover by David Manly. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. REFERENCES Benjamin EJ, Virani SS, Callaway CW, et al. Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation 2018;137(12):e67-492. Erratum in: Circulation 2018;137(12 ):e493. PMID 29386200 Frontera JA, Lewin JJ 3rd, Rabinstein AA, et al. Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine. Neurocrit Care 2016;24(1):6-46. PMID 26714677 Prabhakaran S, Gupta R, Ouyang B, et al. Acute brain infarcts after spontaneous intracerebral hemorrhage: a diffusion-weighted imaging study. Stroke 2010;41(1):89-94. PMID 19892994  We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

CME credits: 1.00 Valid until: 30-09-2023 Claim your CME credit at https://reachmd.com/programs/cme/the-future-of-antithrombotics-and-anticoagulation-perspectives-from-the-esc-2022-congress/14449/ tbd

Drs. Sruthi Arepalli, Avni Finn, and Katherine Talcott join to discuss the June 2022 edition of Retinal Physician, found online at http://www.retinalphysician.com. Topics covered include 27 gauge vitrectomy, heads Up display for retinal surgery, evaluating vitreous floaters, and antithrombotics in retinal surgery.Relevant Financial Disclosures: Dr. Sridhar is a consultant for Alcon, DORC, Genentech, and Regeneron. Dr. Finn is a consultant for Allergan and Genentech. Dr. Talcott is a consultant for Genentech, Regenxbio, and Zeiss. Dr. Arepalli has no relevant disclosures.You can now claim CME credits via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi

Caudal Epidurals on Anti-thrombotics?- Is it safe? Dr. Rosenblum takes a close look at ASIPP's guidelines, and data discussing the risk of hematoma when performing a caudal epidural on a patient who is taking an anti-thrombotic agents and are at high risk for stopping these medications.  Also discussed, Caudal Epidural history, technique and more!  The CME experience for this Podcast is powered by CMEfy - click here to reflect and unlock credits & more: https://earnc.me/daNmJq Upcoming Events... ASIPP's 24th Annual Meeting- May 5th-May 7th, 2022! American Society of Interventional Pain Physicians 24th Annual Meeting is organized by ASIPP and will be held from May 5th–7th, 2022 at the Ceaser's Palace in Las Vegas, Nevada. Get Your Tickets to ASIPP's 24th Annual Meeting Register Now! Ultrasound Experts & NRAP's Ultrasound Workshop May 14th, 2022! 1 day workshop for physicians of all levels who treat pain, perform regenerative medicine procedures, joint injections, and nerve blocks. Get Your Tickets to the Advanced Ultrasound Training Workshop! Register Now! Live Webinar Event- May 18th, 2022! How to Implement Digital Health Tools and Billing Codes to Optimize and Grow your Pain Practice The emergence of new CMS codes in the space of remote physiologic monitoring, remote therapeutic monitoring, chronic care management and more offers a unique opportunity for clinicians and practice owners to get reimbursed for bringing digital health tools into their practice. However, if not done correctly, they can increase the clinical and administrative burden and decrease the patient experience. In this webinar, industry experts will explain the details of these codes and the best ways to introduce them into your practice for optimal growth, without taking on additional burden or risk. Register Now! Advanced Pain Board Review Conference Multi Day June 10-12th, 2022 Multi-Day Advanced Pain Board Review Conference- June 10-12th, 2022 This 2-3 day intensive advanced pain board review workshop has been developed for both novices and advanced pain physicians providers who would like to further advance their skills in pain management procedures. Additional 3rd day is for the Advanced Ultrasound Guided Injection Training CME Course. Participants will have up to 5 hours of hands on ultrasound scanning on live models of different body habitus to learn and identify different sono‐anatomy. Get Your Tickets to the Multi-Day Advanced Pain Board Review & Ultrasound Guided Training Workshop! Register Now! ASPN's Annual Conference- July 14th-17th, 2022! American Society of Pain and Neuroscience Annual Conference is organized by ASPN and will be held from July 14th-17th, 2022 at the Loew's Hotel in Miami Beach, FL.   Get Your Tickets to ASPN's Annual Conference Today! Register Now!   Clarius Discount! Click on the following link and you can enter your credit card info, billing and shipping and your code (DARO) for 20% off! https://store.clarius.com/collections/accessories/products/package-2-in-1-charging-station-hd Podcast Resources: Kaye AD, Manchikanti L, Novitch MB, Mungrue IN, Anwar M, Jones MR, Helander EM, Cornett EM, Eng MR, Grider JS, Harned ME, Benyamin RM, Swicegood JR, Simopoulos TT, Abdi S, Urman RD, Deer TR, Bakhit C, Sanapati M, Atluri S, Pasupuleti R, Soin A, Diwan S, Vallejo R, Candido KD, Knezevic NN, Beall D, Albers SL, Latchaw RE, Prabhakar H, Hirsch JA. Responsible, Safe, and Effective Use of Antithrombotics and Anticoagulants in Patients Undergoing Interventional Techniques: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician. 2019 Jan;22(1S):S75-S128. PMID: 30717501. Simon JI, Caudal Epidural Steroid Injections in the Setting of Remaining on Antithrombotics: A Retrospective StudyPain Physician 2021; 24:E821-E828 • ISSN 2150-1149 New Updates- New 1 on 1 Training Service! New Hospital and Medical Network Group Training Program! Exclusive Dr/Medical Professional affiliate program! Leverage Your Social Network! PainExam "Complete" Complete CME Course now available! Subscribe to the PainExam mailing list * indicates required Email Address * Download the PainExam Official Apps for Android and IOS Devices! https://play.google.com/store/apps/details?id=com.painexam.android.painexam&hl=en_US https://apps.apple.com/us/app/the-pain-management-review/id997396714 Follow PainExam- https://painexam.com/blog/ https://www.facebook.com/PainExam/ https://twitter.com/painexams https://www.instagram.com/painexam/ https://www.linkedin.com/company/painexam https://www.pinterest.com/painexam https://www.youtube.com/user/DocRosenblum/videos

Caudal Epidurals on Anti-thrombotics?- Is it safe? Dr. Rosenblum takes a close look at ASIPP's guidelines, and data discussing the risk of hematoma when performing a caudal epidural on a patient who is taking an anti-thrombotic agents and are at high risk for stopping these medications.  Also discussed, Caudal Epidural history, technique and more!  The CME experience for this Podcast is powered by CMEfy - click here to reflect and unlock credits & more: https://earnc.me/daNmJq Upcoming Events... ASIPP's 24th Annual Meeting- May 5th-May 7th, 2022! American Society of Interventional Pain Physicians 24th Annual Meeting is organized by ASIPP and will be held from May 5th–7th, 2022 at the Ceaser's Palace in Las Vegas, Nevada. Get Your Tickets to ASIPP's 24th Annual Meeting Register Now! Ultrasound Experts & NRAP's Ultrasound Workshop May 14th, 2022! 1 day workshop for physicians of all levels who treat pain, perform regenerative medicine procedures, joint injections, and nerve blocks. Get Your Tickets to the Advanced Ultrasound Training Workshop! Register Now! Live Webinar Event- May 18th, 2022! How to Implement Digital Health Tools and Billing Codes to Optimize and Grow your Pain Practice The emergence of new CMS codes in the space of remote physiologic monitoring, remote therapeutic monitoring, chronic care management and more offers a unique opportunity for clinicians and practice owners to get reimbursed for bringing digital health tools into their practice. However, if not done correctly, they can increase the clinical and administrative burden and decrease the patient experience. In this webinar, industry experts will explain the details of these codes and the best ways to introduce them into your practice for optimal growth, without taking on additional burden or risk. Register Now! Advanced Pain Board Review Conference Multi Day June 10-12th, 2022 Multi-Day Advanced Pain Board Review Conference- June 10-12th, 2022 This 2-3 day intensive advanced pain board review workshop has been developed for both novices and advanced pain physicians providers who would like to further advance their skills in pain management procedures. Additional 3rd day is for the Advanced Ultrasound Guided Injection Training CME Course. Participants will have up to 5 hours of hands on ultrasound scanning on live models of different body habitus to learn and identify different sono‐anatomy. Get Your Tickets to the Multi-Day Advanced Pain Board Review & Ultrasound Guided Training Workshop! Register Now! ASPN's Annual Conference- July 14th-17th, 2022! American Society of Pain and Neuroscience Annual Conference is organized by ASPN and will be held from July 14th-17th, 2022 at the Loew's Hotel in Miami Beach, FL.   Get Your Tickets to ASPN's Annual Conference Today! Register Now!   Clarius Discount! Click on the following link and you can enter your credit card info, billing and shipping and your code (DARO) for 20% off! https://store.clarius.com/collections/accessories/products/package-2-in-1-charging-station-hd Podcast Resources: Kaye AD, Manchikanti L, Novitch MB, Mungrue IN, Anwar M, Jones MR, Helander EM, Cornett EM, Eng MR, Grider JS, Harned ME, Benyamin RM, Swicegood JR, Simopoulos TT, Abdi S, Urman RD, Deer TR, Bakhit C, Sanapati M, Atluri S, Pasupuleti R, Soin A, Diwan S, Vallejo R, Candido KD, Knezevic NN, Beall D, Albers SL, Latchaw RE, Prabhakar H, Hirsch JA. Responsible, Safe, and Effective Use of Antithrombotics and Anticoagulants in Patients Undergoing Interventional Techniques: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician. 2019 Jan;22(1S):S75-S128. PMID: 30717501. Simon JI, Caudal Epidural Steroid Injections in the Setting of Remaining on Antithrombotics: A Retrospective StudyPain Physician 2021; 24:E821-E828 • ISSN 2150-1149 New Updates- New 1 on 1 Training Service! New Hospital and Medical Network Group Training Program! Exclusive Dr/Medical Professional affiliate program! Leverage Your Social Network! PainExam "Complete" Complete CME Course now available! Subscribe to the PainExam mailing list * indicates required Email Address * Download the PainExam Official Apps for Android and IOS Devices! https://play.google.com/store/apps/details?id=com.painexam.android.painexam&hl=en_US https://apps.apple.com/us/app/the-pain-management-review/id997396714 Follow PainExam- https://painexam.com/blog/ https://www.facebook.com/PainExam/ https://twitter.com/painexams https://www.instagram.com/painexam/ https://www.linkedin.com/company/painexam https://www.pinterest.com/painexam https://www.youtube.com/user/DocRosenblum/videos

Caudal Epidurals on Anti-thrombotics?- Is it safe? Dr. Rosenblum takes a close look at ASIPP's guidelines, and data discussing the risk of hematoma when performing a caudal epidural on a patient who is taking an anti-thrombotic agents and are at high risk for stopping these medications.  Also discussed, Caudal Epidural history, technique and more!  The CME experience for this Podcast is powered by CMEfy - click here to reflect and unlock credits & more: https://earnc.me/daNmJq Upcoming Events... ASIPP's 24th Annual Meeting- May 5th-May 7th, 2022! American Society of Interventional Pain Physicians 24th Annual Meeting is organized by ASIPP and will be held from May 5th–7th, 2022 at the Ceaser's Palace in Las Vegas, Nevada. Get Your Tickets to ASIPP's 24th Annual Meeting Register Now! Ultrasound Experts & NRAP's Ultrasound Workshop May 14th, 2022! 1 day workshop for physicians of all levels who treat pain, perform regenerative medicine procedures, joint injections, and nerve blocks. Get Your Tickets to the Advanced Ultrasound Training Workshop! Register Now! Live Webinar Event- May 18th, 2022! How to Implement Digital Health Tools and Billing Codes to Optimize and Grow your Pain Practice The emergence of new CMS codes in the space of remote physiologic monitoring, remote therapeutic monitoring, chronic care management and more offers a unique opportunity for clinicians and practice owners to get reimbursed for bringing digital health tools into their practice. However, if not done correctly, they can increase the clinical and administrative burden and decrease the patient experience. In this webinar, industry experts will explain the details of these codes and the best ways to introduce them into your practice for optimal growth, without taking on additional burden or risk. Register Now! Advanced Pain Board Review Conference Multi Day June 10-12th, 2022 Multi-Day Advanced Pain Board Review Conference- June 10-12th, 2022 This 2-3 day intensive advanced pain board review workshop has been developed for both novices and advanced pain physicians providers who would like to further advance their skills in pain management procedures. Additional 3rd day is for the Advanced Ultrasound Guided Injection Training CME Course. Participants will have up to 5 hours of hands on ultrasound scanning on live models of different body habitus to learn and identify different sono‐anatomy. Get Your Tickets to the Multi-Day Advanced Pain Board Review & Ultrasound Guided Training Workshop! Register Now! ASPN's Annual Conference- July 14th-17th, 2022! American Society of Pain and Neuroscience Annual Conference is organized by ASPN and will be held from July 14th-17th, 2022 at the Loew's Hotel in Miami Beach, FL.   Get Your Tickets to ASPN's Annual Conference Today! Register Now!   Clarius Discount! Click on the following link and you can enter your credit card info, billing and shipping and your code (DARO) for 20% off! https://store.clarius.com/collections/accessories/products/package-2-in-1-charging-station-hd Podcast Resources: Kaye AD, Manchikanti L, Novitch MB, Mungrue IN, Anwar M, Jones MR, Helander EM, Cornett EM, Eng MR, Grider JS, Harned ME, Benyamin RM, Swicegood JR, Simopoulos TT, Abdi S, Urman RD, Deer TR, Bakhit C, Sanapati M, Atluri S, Pasupuleti R, Soin A, Diwan S, Vallejo R, Candido KD, Knezevic NN, Beall D, Albers SL, Latchaw RE, Prabhakar H, Hirsch JA. Responsible, Safe, and Effective Use of Antithrombotics and Anticoagulants in Patients Undergoing Interventional Techniques: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician. 2019 Jan;22(1S):S75-S128. PMID: 30717501. Simon JI, Caudal Epidural Steroid Injections in the Setting of Remaining on Antithrombotics: A Retrospective StudyPain Physician 2021; 24:E821-E828 • ISSN 2150-1149 New Updates- New 1 on 1 Training Service! New Hospital and Medical Network Group Training Program! Exclusive Dr/Medical Professional affiliate program! Leverage Your Social Network! PainExam "Complete" Complete CME Course now available! Subscribe to the PainExam mailing list * indicates required Email Address * Download the PainExam Official Apps for Android and IOS Devices! https://play.google.com/store/apps/details?id=com.painexam.android.painexam&hl=en_US https://apps.apple.com/us/app/the-pain-management-review/id997396714 Follow PainExam- https://painexam.com/blog/ https://www.facebook.com/PainExam/ https://twitter.com/painexams https://www.instagram.com/painexam/ https://www.linkedin.com/company/painexam https://www.pinterest.com/painexam https://www.youtube.com/user/DocRosenblum/videos

Antithrombotics in AF and Bioprosthetic Valve

Brief discussion on choice of antithrombotic agents in patients with chronic coronary syndrome and peripheral artery disease

Three studies revealed new findings on thrombosis in patients with cancer and/or COVID-19. These studies were presented at the 2020 annual meeting of the American Society of Hematology. One study suggested the Khorana score may be ineffective for predicting venous thromboembolism (VTE) in cancer patients. Another study revealed factors that can predict VTE in patients with cancer and COVID-19. And a third study indicated that antithrombotic agents don’t improve outcomes in patients with severe COVID-19.  Kristen M. Sanfilippo, MD, of Washington University, St. Louis, reviews these studies with host David H. Henry, MD, in this episode. Abstract 202: Performance of Khorana Score to Predict One-Year Risk of Venous Thromboembolism in Over Two Million Patients With Cancer. https://bit.ly/3oCHOfQ. The study included 2,112,260 patients with cancer. At 1 year after diagnosis, 227,170 (10.8%) patients had developed VTE. The Khorana score was a weak to modest predictor of the 1-year risk of VTE (area under the curve, 0.565; 95% confidence interval, 0.564-0.566). Abstract 204: Incidence of and Risk Factors for Venous Thromboembolism Among Hospitalized Patients With Cancer and COVID-19: Report From the COVID-19 and Cancer Consortium (CCC19) Registry. https://bit.ly/38waPnX. The study included 1,813 hospitalized patients with COVID-19 and cancer who were enrolled in the CCC19 registry. Patients had an increased risk of VTE if they had received anticancer therapy in the last 3 months (odds ratio, 1.63), had active disease (OR, 1.25 for stable/responding disease and 1.67 for progressing disease), had a cancer subtype with a high VTE risk (OR, 1.57 for high risk and 3.42 for very high risk), or were admitted to the ICU within 48 hours of hospitalization (OR, 2.38). Patients had a reduced risk of VTE if they received preadmission anticoagulant (OR, 0.80) or antiplatelet therapy (OR, 0.71). The researchers said this information will aid the development of a risk prediction tool for VTE in hospitalized patients with cancer and COVID-19. For more information on the CCC19 registry, listen to the Blood & Cancer episode, “Studying cancer patients with COVID-19: NCCAPS and CCC19.” https://bit.ly/39lB0x0. Abstract 206: Anticoagulant and Antiplatelet Use not Associated With Improvement in Severe Outcomes in COVID-19 Patients. https://bit.ly/3bvHqvV. This retrospective study included 28,076 patients with confirmed COVID-19 – 1,024 of whom were on antiplatelet agents, anticoagulants, or both. Chronic anticoagulant or antiplatelet use was not associated with a significantly lower risk of VTE (OR, 1.44), emergency department visit (OR, 0.94), ICU stay (OR, 0.87), or death (OR, 0.91). However, anticoagulant or antiplatelet use was associated with a decreased risk of ventilator use (OR, 0.72). Overall, these findings suggest chronic anticoagulant or antiplatelet use don't mitigate disease severity in COVID-19 patients, the researchers concluded. The session in which these abstracts were presented is entitled, “904. Outcomes Research – Non-Malignant Conditions: Venous Thromboembolism Associated With Cancer and/or COVID-19,” and details can be found here: https://bit.ly/39olwIl. Data in some of the abstracts differ from data presented at the meeting. Disclosures Dr. Sanfilippo disclosed relationships with Covington & Burling, Luther & Associates, Bayer, Health Services Advisory Group, and Amgen. Dr. Henry has no relevant disclosures. *  *  * For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgehemonc David Henry on Twitter: @davidhenrymd

Dr. Neil Hayward, CEO and founder of eXlthera, is here to discuss his company, which is developing Factor XI inhibitor antithrombotics that are attacking blood clots from a new angle and are giving patients new hope.

Here is the JournalFeed Podcast for the week of April 20-24, 2020. We cover blunt cerebrovascular injury, head CT in patients on antithrombotic agents, cooling heat stroke victims, avoiding antibiotics in pediatric pneumonia, and surviving quarantine. Special thanks to Lara Fesdekjian for writing theme music!

In today's VETgirl online veterinary continuing education podcast, we interview fellow criticalist, Dr. Armelle de Laforcade, DACVECC from Tufts Cummings School of Veterinary Medicine on the newest guidelines released by the American College of Veterinary Emergency and Critical Care called Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE).

In today's VETgirl online veterinary continuing education podcast, we interview fellow criticalist, Dr. Armelle de Laforcade, DACVECC from Tufts Cummings School of Veterinary Medicine on the newest guidelines released by the American College of Veterinary Emergency and Critical Care called Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE).

Today joining Brian and myself in the studio we are delighted to have Professor Dan Chan, our Head of Department here at the RVC. We could talk to him about so many things, though he has recently been involved in the Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE) and we thought that we’d have a chat with him about that. Enjoy. The whole Consensus is available in a Special Issue in the Journal of Veterinary Emergency and Critical Care open access here; https://onlinelibrary.wiley.com/toc/14764431/2019/29/1 If you have any comments about this podcast, please get in touch: email dbarfield@rvc.ac.uk; tweet @dombarfield. We would greatly appreciate your time to rate us on Apple podcast or Acast and kindly write us a review.

Today joining Brian and myself in the studio we are delighted to have Professor Dan Chan, our Head of Department here at the RVC. We could talk to him about so many things, though he has recently been involved in the Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE) and we thought that we’d have a chat with him about that. Enjoy. The whole Consensus is available in a Special Issue in the Journal of Veterinary Emergency and Critical Care open access here; https://onlinelibrary.wiley.com/toc/14764431/2019/29/1 If you have any comments about this podcast, please get in touch: email dbarfield@rvc.ac.uk; tweet @dombarfield. We would greatly appreciate your time to rate us on Apple podcast or Acast and kindly write us a review.

REstart or STop Antithrombotics Randomised Trial for oral anticoagulants. We talked results with Prof. Rustam Al-Shahi Salman from the University of Edinburgh.  

Unfortunately, stroke is all too common. Nearly 1 million new strokes are diagnosed in the US each year. And this means that complications of stroke--even if rare--may also be common. One such complication is hemorrhagic transformation. This week, Dr. Ava Liberman reviews a clinical case of hemorrhage following ischemic stroke. Produced by James E. Siegler. Music by Ghost, Kevin McLeod, and Scott Holmes. Voiceover by David Manly. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. REFERENCES Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, de Ferranti SD, Ferguson JF, Fornage M, Gillespie C, Isasi CR, Jimenez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Lutsey PL, Mackey JS, Matchar DB, Matsushita K, Mussolino ME, Nasir K, O'Flaherty M, Palaniappan LP, Pandey A, Pandey DK, Reeves MJ, Ritchey MD, Rodriguez CJ, Roth GA, Rosamond WD, Sampson UKA, Satou GM, Shah SH, Spartano NL, Tirschwell DL, Tsao CW, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P, American Heart Association Council on E, Prevention Statistics C and Stroke Statistics S. Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation. 2018;137:e67-e492. Frontera JA, Lewin JJ, 3rd, Rabinstein AA, Aisiku IP, Alexandrov AW, Cook AM, del Zoppo GJ, Kumar MA, Peerschke EI, Stiefel MF, Teitelbaum JS, Wartenberg KE and Zerfoss CL. Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine. Neurocritical care. 2016;24:6-46. Prabhakaran S, Gupta R, Ouyang B, John S, Temes RE, Mohammad Y, Lee VH and Bleck TP. Acute brain infarcts after spontaneous intracerebral hemorrhage: a diffusion-weighted imaging study. Stroke; a journal of cerebral circulation. 2010;41:89-94.

Commentary by Dr. Valentin Fuster

Beaming out from the NUH DREEAM recording booth comes the second part of the Therapeutics specials on Antithrombotics where our ED Pharmacist Kunal takes us through anticoagulants. We cover the clotting cascade, Heparins, Coumarins, DOACs, Fundoparinux and Thrombolytics. As ever Kunal shares his great knowledge including the reason why warfarin might actually increase your risk of clot! Check out www.takeaurally.com for more information including the Take Visually for this episode. Remember to follow Take Aurally and NUH DREEAM on Facebook and Twitter.

In this episode our favourite Pharmacist Kunal Gohil joined us in DREEAM once again this time to cover antithrombotics. In part one we discuss antiplatetets. Whilst the focus is on Aspirin and Clopidogrel we also cover Prasugrel and Ticagrelor with plenty of pharmacology along the way. Visit TakeAurally.com for more information including the Take Visually for this episode. Remember both DREEAM and Take Aurally are on Facebook and Twitter. Part 2 covering anticoagulants will be coming soon!

Today we welcome one of the gurus in anti-coagulant reversal, John J. Lewin. Dr. Lewin recently published one of the recent landmark articles in the field of Neurocritical care: "Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage". Today he is gracious enough to spend 60 minutes with us, and not a second can be missed if you EVER expect to take care of a patient with a head bleed on AC!!

Neurocritical Care Society and Society for Critical Care Medicine recommendations for reversal of antithrombotic agents in patients with intracranial hemorrhage Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage : A Statement for Healthcare Professionals from the Neurocritical Care Society... - PubMed - NCBI http://www.ncbi.nlm.nih.gov/pubmed/26714677 Antithrombotic: Timing, Antidote, Factor Replacement, antifibrinolytics Vitamin K antagonists (warfarin) If INR > 1.3 then Vitamin K 10 mg IV, plus 3 or 4 factor PCC IV (dosing based on weight, INR and PCC type) OR FFP 10–15 ml/kg IV if PCC not available Direct factor Xa inhibitors: activated charcoal (50 g) within 2 h of ingestion, activated PCC (FEIBA) 50 units/kg IV OR 4 factor PCC 50 units/kg IV Direct thrombin inhibitors (dabigatran): Activated charcoal (50 g) within 2 h of ingestion, AND Activated PCC (FEIBA) 50 units/kg IV OR 4 factor PCC 50 units/kg IV Idarucizumab 5 g IV (in two 2.5 g/50 mL vials) consider hemodialysis or idarucizumab redosing for refractory bleeding after initial administration if 1) dabigatran was taken with 3-5 half lives and NO evidence of renal insufficiency or 2) dabigatran was taken beyond 3-5 half lives WITH renal insufficiency For other DTIs: Activated PCC (FEIBA) 50 units/kg IV OR 4 factor PCC 50 units/kg IV Unfractionated heparin: Protamine 1 mg IV for every 100 units of heparin administered in the previous 2–3 h (up to 50 mg in a single dose) LMWH Enoxaparin: Dosed within 8 h: Protamine 1 mg IV per 1 mg enoxaparin (up to 50 mg in a single dose) Dosed within 8–12 h: Protamine 0.5 mg IV per 1 mg enoxaparin (up to 50 mg in a single dose) Minimal utility in reversal >12 h from dosing Dalteparin, Nadroparin and Tinzaparin: Dosed within 3–5 half-lives of LMWH: Protamine 1 mg IV per 100 anti-Xa units of LMWH (up to 50 mg in a single dose) OR rFVIIa 90 mcg/kg IV if protamine is contraindicated Danaparoid: rFVIIa 90 mcg/kg IV Pentasaccharides: Activated PCC (FEIBA) 20 units/kg IV or rFVIIa 90 mcg/kg IV Thrombolytic agents (plasminogen activators): Cryoprecipitate 10 units IV OR antifibrinolytics (tranexamic acid 10–15 mg/kg IV over 20 min or e-aminocaproic acid 4–5 g IV) if cryoprecipitate is contraindicated Antiplatelet agents: DDAVP 0.4 mcg/kg x 1, if neurosurgical intervention, transfuse one apheresis unit

Editor's Audio Summary by Howard Bauchner, MD, Editor in Chief of JAMA, the Journal of the American Medical Association, for the February 24, 2015 issue

Antiplatelets: ASA Clopidogrel Anticoagulants: Warfarin Apixaban Dabigatran Rivaroxaban Clotting Cascade: Clotting Factor Song, by Emily Anne Nagler: Twelve, eleven, nine, it’s clotting factor time 8 and 9 to 10a 5, that’s how we stay alive Don’t forget to say: the tissue factor way 7 to 7a helps 10 go to 10a Then 2 to thrombin, […] The post A Fib 5: Antithrombotics appeared first on Family Pharm Podcast.

Antithrombotic Therapy and Prevention of Thrombosis, 9th ed Guidelines from the American College of Chest Physicians

An interview with Dr Stephen Luby from the International Centre for Diarrhoeal Research in Bangladesh.