Podcasts about blood cancer

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Blood cancers are the fifth most common group of cancers in the UK. But for a small number of people, the condition may have an inherited genetic cause.  In this episode of Behind the Genes, we explore the role of genetics in blood cancer, and what an inherited risk means for patients and their families. Our guests explain what blood cancer is, how inherited factors can increase risk, and why multidisciplinary teamwork is key to supporting families. They also look ahead to future advances, from whole genome sequencing to prevention trials.  Our host Amanda Pichini, Clinical Director at Genomics England, is joined by:  Dr Katie Snape, Principal Clinician at Genomics England and Consultant Cancer Geneticist  Bev Speight, Principal Genetic Counsellor Dr Sarah Westbury, Consultant Haematologist “By doing whole genome sequencing we get all of the information about all of the changes that might have happened, we know whether any are inherited, but importantly, we're certain of the ones that have just occurred in the cancer cells and can help guide us with their treatment.”  You can download the transcript or read it below. Amanda: Hello, and welcome to Behind the Genes.  Sarah: When we think about blood cancers, it's a whole range of different conditions and when you talk to patients who are affected with blood cancers or are living with them, their experiences are often really different from one another, depending in part on what kind of blood cancer they have.  We also know that blood cancers affect not just the cell numbers but also the way that those cells function, and so the range of symptoms that people can get is really variable.  Amanda: I am your host, Amanda Pichini, clinical director at Genomics England and genetic counsellor.  Today I'll be joined by Dr Katie Snape, principal clinician at Genomics England and a consultant cancer geneticist in London, Bev Speight, a principal genetic counsellor in Cambridge, and Dr Sarah Westbury, and haematologist from Bristol.  They'll be talking about blood cancers and the inherited factors that increase blood cancer risk.  If you enjoy this episode, we'd love your support, so please subscribe, rate and share on your favourite podcast app.  Let's get started.  Thanks to everyone for joining us today on this podcast, we're delighted to have so many experts in the room to talk to us about blood cancer.  I'd love to start with each of you introducing yourself and telling us and the listeners a little bit about your role, so, Sarah, could we start with you?  Sarah: Sure.  It's great to be here.  My name's Sarah Westbury, and I'm a consultant haematologist who works down in Bristol.  And my interest in this area is I'm a diagnostic haematologist so I work in the laboratories here in the hospitals, helping to make a diagnosis of blood cancer for people who are affected with these conditions.  And I also look after patients in clinic who have different forms of blood cancer, but particularly looking after families who have an inherited predisposition to developing blood cancer.  And in the other half of my job, I work as a researcher at the University of Bristol.  And in that part of my job, I'm interested in understanding the genetic basis of how blood counts are controlled and some of the factors that lead to loss of control of those normal blood counts and how the bone marrow functions and works.  Amanda: Thank you.  That's really interesting, we'll be looking forward to hearing more about your experience.  Bev, we'll come to you next.  Bev: Thank you.  Hello everyone, I'm Bev Speight, I'm a genetic counsellor, and I work at Addenbrooke's Hospital in Cambridge.  I work with families with hereditary cancers in the clinical genetic service, and for the last six years or so have been focused on hereditary blood cancers.  So we've been helping our haematologists across the region to do genetic tests and interpret the results, and then in my clinic seeing some of the onward referrals that come to clinical genetics after a hereditary cause for blood cancer is found.  I'm also part of the Council for the UK Cancer Genetics Group.  Amanda: Thank you, Bev.  And Katie, over to you.  Katie: Hello, I'm Katie Snape.  I'm a genetics doctor and I am a specialist in inherited cancer.  So we look after anyone who might have an increased chance of developing cancer in their lifetime due to genetic factors.  I am the chair of the UK Cancer Genetics Group, so that's a national organisation to try and improve the quality of care and care pathways for people with inherited cancer risk in the UK.  And I have a special interest in inherited blood cancers through my work at King's College Hospital, I work in the haematology medicine service there seeing individuals who might have or have been diagnosed as having an inherited component to their blood cancers.  So it's great to be here.  Amanda: Excellent, thank you for those introductions.  I'd like to then dive right in and understand a little bit more about blood cancers.  So, Sarah, could you tell us a little bit more about what blood cancer is?  Sarah: Yes, sure.  The term blood cancer is used to describe a whole range of different kinds of cancer, all of which affect some part of the blood or sometimes parts of the immune system that kind of gets represented as part of the blood.  So it's really describing a big group of conditions rather than one single kind of condition or entity itself.  But like any form of cancer, we understand blood cancers as being conditions where because cells as part of the blood system are rapidly dividing and normally doing so under really well controlled circumstances to produce just the right balance of blood cells and just the right number of those cells.  In a cancer affecting those cells, we see that that loss of control results in either too many of one type of blood cell being produced or too few, or that balance being lost.  And like any form of cancer, this is because of genetic changes that happen in individual cells that then go on to grow in a way that is not controlled and well regulated.    And because when we talk about blood cancer we're talking about such a wide range of different kinds of cancer affecting different cells within that blood system, there's a really wide range of different conditions.  From conditions that we might think of as being like a form of acute leukaemia, so something that produces often symptoms and signs in patients very quickly and they can often feel quite unwell quite soon and then get picked up with having this condition because they present feeling unwell.  All the way to chronic and slow growing cancers that can be found completely by chance and serendipity when blood tests are done for other reasons.  So when we think about blood cancers, it's a whole range of different conditions.  And when you talk to patients who are affected with blood cancers or are living with them, their experiences are often really different from one another, depending in part on what kind of blood cancer they have.  We also know that blood cancers affect not just the cell numbers, but also the way that those cells function.  And so the range of symptoms that people can get is really variable, again depending on which of the blood cells are really affected by that.  And it may be that during the course of some of the conversations we have today in this podcast, we'll perhaps focus on particular kinds of blood cancer.  But like any cancer, it's that disruption of the normal growth and development of cells that means that the number and function of those blood cells has been disrupted in some way.  Amanda: Thank you so much for explaining that, Sarah, that's really helpful.  In terms of across the range of blood cancers, is that something that people can get at any age, and how common is it?  Sarah: It does depend, as we were sort of talking about that really wide range of different disorders that make up that group of blood cancers.  And individually each of those blood cancers is reasonably uncommon compared to cancers that we might typically think of, like breast cancer or colon cancer.  But actually, if you group blood cancers together, they make up quite a sizeable proportion, and they're actually as a group the fifth most common form of cancer that's diagnosed in people in the UK.  In adults in particular we think that perhaps people diagnosed with leukaemia would make up about 3% of the new diagnosis of cancer made in any year.  Amanda: So coming to you, Bev, when we talk about inherited blood cancers, what are the differences between those and blood cancers more generally?    Bev: So at point of diagnosis, it may not be obvious that somebody with a new blood cancer diagnosis is one of the minority of people in that big group as Sarah has described, who has an inherited cause.  So it may not be immediately obvious.  However, in the last few years certainly, it's become more and more routine to do quite broad genetic testing.  Often on a bone marrow sample or blood, because that is done looking for genetic changes, which are part of all cancer and we find within cancer cells, that can help with treatment planning.  It can also find that there is an inherited cause to that new blood cancer diagnosis.  Sometimes that might not be clear cut, sometimes that might be inferred from the genetic tests that are done on the blood or the bone marrow. And the proportion of blood cancers in that huge group which do have an inherited cause is fairly small, the actual proportion will depend a bit on the age of the patient and the specific subtype of blood cancer.  Amanda: Okay, and could you talk us through how some of those inherited genetic factors can increase the chance of a person developing blood cancer, how does that work?  Bev: Yes, so if we know that there is an inherited cause for blood cancer, then what we mean by that most of the time is that a change in a single gene has been found.  And that there is enough research evidence and enough known about that specific change in that gene to say to the person who's been diagnosed, there is at least in part or perhaps a full explanation for why that blood cancer has developed and this could be shared in the family.  So at that point it's information that not only has implications for the person in treatment, but also their relatives.  Depending on what sort of gene alteration it is and which gene it's found in, there are different inheritance patterns, and that changes the sorts of information that we give about risks for relatives.  So for lots of the genetic tests that detect an inherited cause in adults when they're diagnosed, that's most often what we would call an autosomal dominant inheritance pattern.  Essentially that means you only need to have one gene alteration which is in that person's normal non-cancerous DNA inherited from a parent and can be passed onto a child.  And for people in the family who have inherited this one genetic change, then they are likely to be at increased risk of developing blood cancer.  Sometimes with particularly the children's blood cancers, if an inherited cause is found, it can be a different pattern, which we call autosomal recessive.  And that's where two gene changes are found and one has been inherited from each parent.  So parents might be what we call carriers and have one each just by chance, both have been passed onto a child who has developed blood cancer either in childhood or possibly later on, and that's the pattern we call autosomal recessive.  There are other inheritance patterns too.  The third one that we come across being X-linked, and so that has a gender component.  That's where there's a change on the X chromosome, women have two X's, and men have one X and one Y.  So sometimes with the X-linked conditions we're more likely to see the clinical signs of a condition in boys and men because they've only got that one X chromosome.  But those are less common in the context of talking about hereditary blood cancers.  Amanda: Thank you.  That's really helpful to understand.  So it sounds like you're saying that these forms of blood cancers that are caused by a single gene are relatively rare.  And also by having one of these changes, it's not a given that that person will develop a blood cancer, but it makes them more likely, and how likely that is might depend on the inheritance pattern or the type of condition.  Bev: That's right.  So what we're saying is it can give either part of full explanation for the blood cancer diagnosis, and it could confer a risk to family members, but that doesn't mean they definitely will develop it.  We're talking about an increased risk compared to the population risk.  Amanda: Right.  I can imagine for those families to some extent it might be helpful to know the underlying reason why they had that blood cancer, but again, that's just a small proportion.  So, Katie, could I come to you next?  What about the rest of all the blood cancers, how do they occur?  Katie: Yes, thanks, Amanda.  So most blood cancers will occur just by chance.  We also know that there are some environmental factors that can increase the risk of blood cancers, so, for example, serious radiation exposure, something like that.  What Bev has described is where there is this sort of quite rare condition where there is a kind of single gene that's really important for the blood cells in terms of keeping those control mechanisms that Sarah described.  And that's not working properly, which has increased the risk of a blood cancer.  But we also sometimes see some families where there is more blood cancer, or the same type of blood cancer in that family than we might expect by chance.  We think that's probably not due to a single high risk genetic factor, but might be due to kind of multiple lower risk genetic factors that are sort of shared by close family members and can add up together to increase the risk a little bit.  And we call that familial risk or polygenic risk.  We don't have a test for that at the moment.  We wouldn't offer usually any extra screening or testing to those families, but we would just suggest obviously family members are aware of any signs of symptoms of blood cancers and seek any advice if they're concerned.  But, you know, the majority of blood cancers are not due to genetic factors, and it's sort of environmental or chance or bad luck. Amanda: Okay, so it's clear that obviously blood cancer is almost an oversimplification, within that category there's so many different types, so many ways that it could happen in a person.  So, Bev, if we're dealing with that type of blood cancer that is inherited or has some heritability, can you tell us more about what that means for the family?  What kind of impacts do you see that having for them?  Bev: Yes, of course.  So clearly this is another layer of information that's often coming at a family during a time where somebody is often recently diagnosed with blood cancer of one sort or another and is having to take in a lot of information about treatment and all of the uncertainty and anxiety that goes with that.  So for this minority of patients and families where there is new information about an inherited cause, that needs conveying in a timely but sensitive way, bearing in mind what else is happening.  And for some people it can come as a major shock and really an additional burden at that time.  I think the reaction to that will of course depend on lots of factors.  And what we also see is that this question about a new cancer diagnosis of any sort, including blood cancers, can generate the question in people's mind, particularly if they've got children, about does this change the risk for relatives?  So sometimes this new information that, actually, there is an inherited cause is an answer to a question that families have already got.  And that might be because of what Katie's described as familial clustering, there might already have been this known history in the family. So sometimes this information can feed into that and actually be quite a helpful answer.  But it's quite normal for families to feel quite mixed about this and for different family members to have a different approach to it.  When there's the offer of what we would call predictive testing, if we found a change in a single gene in somebody with blood cancer which we're saying is a hereditary cause for that, that might open the door for relatives to access predictive testing.  I.e., the opportunity to discuss and possibly take up a genetic test for themselves when they haven't had cancer themselves, but there's an opportunity to try and quantify whether or not they're at increased risk.  We know in families the uptake of those kinds of tests is different, and a lot of it is to do with timing and the way people respond to this in families might depend on their response to the cancer diagnosis in their relative, and of course what else is going on in their life at the time.  This aspect for the family is where clinical genetic services come in, because these initial tests in the person with blood cancer are done in their haematology/oncology setting, and normally the results about an inherited cause has been found are conveyed through that service.  That's when a referral to clinical genetics happens.  And in our specialist service we're addressing those additional concerns for the family which arise because of this diagnosis. Amanda: Thanks, Bev, for explaining that.  Sarah, coming back to you.  Could you tell me then if someone has an inherited blood cancer does it also change the way that the patient is treated? Sarah: Well, it certainly can do, and again, it does depend a little bit on the specific circumstances of that particular person and the form of inherited blood cancer predisposition that they have.  But certainly if we think about treatment as a whole, then for a lot of people it does affect the way that we might recommend treatments or look after them and their families.  So, for example, for some patients who have a diagnosis of an inherited form of blood cancer, we know that some treatments might be more or less effective for their particular set of circumstances.  And so that can sometimes influence the specific treatment recommendations that we would make, particularly thinking about, for example, the risks that the cancer might come back again after it's been treated.  Or thinking about whether or not some of the typical drug regimes that might be used might be perhaps more likely to cause them side effects or problems with tolerating that treatment.  So it can certainly make some changes in that respect. For some people, to be fair a minority of people with blood cancers, they may need a stem cell transplant as part of their treatment to hopefully cure them of their blood cancer.  And this as I say is a treatment that's required for a minority of patients as a whole who have a diagnosis of a blood cancer.  But for those people who have got an inherited predisposition and who might be recommended a stem cell transplant as part of their treatment, then knowing about a familial risk for this condition can also be really important.  For making sure that if a family member is being considered as a donor for example that we're being really careful to make sure that we're not choosing a donor that might also be affected by the same underlying blood cancer predisposition.  Because this can obviously cause problems for the person that's receiving the stem cells if it turns out that the person they're receiving them from actually has the same inherited condition as them.  So in that respect knowing about the underlying predisposition and genetic cause for their cancer can be helpful.  But in a more sort of general sense, yes, the other thing that it can have a big difference for is that some of these inherited cancer predispositions and syndromes also have other health conditions associated with them.  So it might be that that genetic diagnosis predisposes somebody not only to a form of blood cancer but to other health conditions as well.  And so actually knowing about that diagnosis can help their haematologist then make sure that they're linked in with the right other medical teams to make sure that those other health conditions are identified if they're present and taken care of.  And then I think really coming back to what Bev has already touched on, there's the sort of bigger picture of just how people are looked after in their own right but also as part of their family unit.  And making sure that they're given the right information and advice about their health, but also thinking about other family members.  And particularly for younger patients who perhaps either are just starting their own families or for whom that's not yet a consideration, making sure that they've got the information to understand what might be relevant for future family members, if that makes sense.  So it's not necessarily true to say that for every individual patient knowing that there's an inherited blood cancer present will necessarily directly affect the way that the treatment is offered.  But you can see that as a part of a bigger picture for a lot of patients, it will make a difference to their care as a whole.  Amanda: And you can really see how the impact is very sort of multigenerational and is going to affect people at all ages and stages of their life, so that's really interesting.  Katie, Bev spoke a little earlier about the fact that there are genetic tests that can help tell us if blood cancer is inherited.  Could you tell us more about what the tests involve, and some of your experience taking families through this?  Katie: There's sort of two main different ways that we might identify somebody has an inherited cause for their blood cancer through testing.  So traditionally what has happened, as Bev and Sarah sort of discussed before, is that when a person is diagnosed with a blood cancer, we either take a sample of their blood or bone marrow.  To try and look at what are the changes within those cells that have driven that cell to become a cancer cell and have driven this blood cancer to develop.  And a lot of the time, as we've said, it's not inherited, it's not genetic, so they're what we call acquired changes, they're changes that have just happened in the bone marrow or to the blood cells that have caused that kind of particular cell to become a cancer cell.  And it's really important that we look at those because that can help both diagnose the blood cancer, it can give us information about how serious that blood cancer might be, and it can also help us guide our treatments and therapies.  And so if we do those testings, they're primarily done within haematology for those sort of diagnostic or prognostic or treatment purposes.  We do sometimes see then a change that looks a bit suspicious that it might be inherited for various reason.  And if we see something that is in the cancer and it looks like there's a potential it could be inherited, we would go on and do a second test.  So usually because we can't do a blood test because the cancer's in the blood, we would take a skin biopsy.  And then we would look and see, well, is this change also present in the skin?  And if it is, then that indicates that that change is in all of the cells of the body, because it's in both the blood cancer and it's in the skin, and therefore it's likely to be inherited.  So that's one thing that we do.  And I think that that can be quite challenging for patients.  Because they go in to have a test for their blood cancer and then suddenly were being told, “Well, actually, we've also found something that might be inherited,” and it is something then that other members of the family might have.  And as Sarah said, potentially that means that even if your relative was offering to be a bone marrow donor for you, they might not be able to if they also carry the same thing.  And so that can be quite tricky just in terms of making sure that we're guiding the patient and their family members through that process.  And then thinking about the work that Genomics England does, particularly with whole genome sequencing, and this is particularly offered for children and young adults in the paediatric setting.  But I think we're also increasingly, as we progress we'll perhaps talk about this a bit, moving towards whole genome sequencing for adult blood cancers more routinely as well, that that is offered as a sort of standard of care.  And what whole genome sequencing is, is it is looking at the entire genetic instruction manual in both the blood cancer cells and in the cells that we're born with, to look at the inherited or germline genome as well.  And the reason that we look at both the cancer cells and the inherited or germline genome is because what we're trying to understand is firstly, are there any inherited changes that have led to the blood cancer developing?  But also, what are the changes that have just occurred in the cancer cells that are going to help us to diagnose and treat that blood cancer?  So by doing whole genome sequencing we get all of the information about all of the changes that might have happened, we know whether any are inherited, but importantly, we're certain of the ones that have just occurred in the cancer cells and can help guide us with their treatment.  And so, again, when we're talking to patients, we have to explain to them that we're going to be looking at their entire genetic information.  And what's interesting about that is it might find things that are not only relevant to blood cancer, but very rarely other findings, incidental findings as well, or we might find things that we don't know about.  But I think certainly that's something that patients often feel very comfortable with having because it gives them the maximum amount of information.  Amanda: Thanks, Katie.  So it really sounds like there's a lot of advancements that are being made in genetic technology which potentially brings a lot of new things for you and Bev as genetic specialists, but also for you, Sarah, as a haematology specialist.  What does that kind of change for you, and I assume it's really important then for you all to be working together as a multidisciplinary team?  Katie: Yes, I mean, I think for clinical genetics, we were not involved in sort of haematology pathways for a really long time, and the haematologists are absolute experts in the genomic factors that drive blood cancers.  And certainly in my practice, it's really only been as the technology advanced that we really started finding more and more of these inherited factors, particularly in the adult setting.  Because I think in the paediatric and childhood setting, the haematologists again have been managing those conditions very well for years.  And I think there's places that we really interface and we really need to work together as a multidisciplinary team, understanding the genetic information, really understanding when something that we've seen in the blood cancer or the bone marrow could be inherited.  Do we need to check that?  What should that pathway look like?  But I think as you've said, a lot of these are actually really quite new conditions, particularly in the adult setting.  And we don't yet 100% know why do some people get blood cancer and some people don't when they have the same inherited factor.  What's the actual risk?  Are there any other factors modifying it?  What makes some people progress to develop a blood cancer and some people not?  And for that we really need to work together to try and gather the data and sort of capture people that have these inherited changes.  And hopefully develop a system and an infrastructure that we can follow it long-term and get a lot of information about long-term outcomes, both for individuals with cancer but also their families.  And also from looking at doing population studies.  Because I think we know that lots of people in the general population might carry some of these inherited changes and never develop a blood cancer as a result of this, certainly ones that seem a bit lower risk.  So we really need to work together to understand all of that.  But I'd be really interested in Sarah's views on that as well.  Sarah: Yes, sure.  So I think, as you say, Katie, haematologists have got a long history of understanding and interpreting genetic findings in the sort of acquired or somatic changes that we know are what occurs in some blood cells to drive the cancer forming in the first place. But this kind of newer integration of that with the germline testing is something that is becoming much more mainstream in haematology now, and I think something that people have had to sort of acquire new skills in this area to interpret that alongside.  I think as you say, that multidisciplinary working, where we're able to benefit from both sides of our expertise and knowledge and put that together is so valuable, particularly in those circumstances where there is some uncertainty.  And I think as a haematologist, one of the things that I really find a benefit both personally and professionally to help me navigate these tricky questions but that I also think patients benefit from is your expertise and ability to have those really quite tricky conversations with people who are not haematology patients, if that makes sense.  So they may be the relatives of patients who have a haematological diagnosis for example.  Who at the moment are entirely well and were just going about their daily business, and they're now told that they may or may not potentially have this inherited predisposition.  And I think that as haematologists, we're very used to dealing with potentially quite poorly patients, potentially quite scared patients who find themselves, you know, the recipient of all this quite difficult information.  But we're not necessarily so skilled and experienced at holding conversations with people who don't yet have that diagnosis.  And I think that that's a really rich area of mutual aid to one another as haematologists and genetic doctors, if that makes sense.  And I think your points about understanding actually the real risks and the nature history, as we would call it, of what happens to people who carry these variants that predispose them to blood cancers is something that we can probably only work out by working together.  And of course, working with the patients and families that are affected by these conditions so that hopefully for both sides in the future we'll be able to give much better advice to patients and their families.  Amanda: So, Bev, from your experience and as a genetic counsellor, what do you feel are the important things that patients and their families should know as they're going through this testing and diagnosis process?  Bev: The things I think families where there is a hereditary cause found should know is that with this new information comes a whole new referral to a dedicated service.  Who want to help patients and their family members at risk to navigate this, to adjust the information, and to make decisions that fit with them, about whether to have testing and the timing of that.  As we already said, where there is a hereditary blood cancer risk, that risk in family members is rarely 100%.  Depending on what the hereditary predisposition is in the family, we may be able to quantify that risk, sometimes we can't always.  And the other thing to know which links to that is that there is growing interest in research in this area.  That will really help us to improve care in terms of, for example, being able to quantify the risk of developing a blood cancer in relatives who are perfectly well that may have inherited these predisposition gene changes.  Or, for example, the other obvious place where we want to make improvements in terms of some sort of evidence-based surveillance for those people who want to find out that they have inherited the genetic change and are at increased risk.  Amanda: Thank you.  And overall there's been a lot I think we've been covering today that's probably going to be very new to many people.  Why do you think it's important to raise public awareness of inherited blood cancers?  Bev: There have been lots of public awareness campaigns about other cancers, as listeners probably can think about, in terms of for women checking their breasts and breast cancer awareness.  And perhaps there's been a bit less of that in general for blood cancers.  As we've already talked about, clinical genetics were not so involved in all of the genetic testing happening in blood cancers.  Because it wasn't so long ago in the history of how we think about inherited cancers in general that our suspicion of inherited causes in leukaemia was much lower than it is now.  So I think that awareness in the public probably will take a bit more effort to bring up.  But clearly public awareness about blood cancers in general, symptom awareness, and the fact that occasionally it can be something that is running in the family, clearly better public awareness of that means that people are empowered to ask the right questions.  And the questions that might already be in some way going through their minds of their haematology doctors or perhaps of their GP, if they've got a family history but are not affected themselves.  Amanda: Wonderful.  So, looking now to the future, Katie, what genomic advancements are we seeing or are we likely to see that could impact on the care of people with an increased genetic risk of blood cancer?  Katie: We touched a little bit, I think that whole genome sequencing is expanding.  And as we can turn that test around and get it back more quickly that might become more commonplace.  And I know Genomics England and the UK Haemato-oncology Network of Excellence have been doing a lot of work in that area.  We are very lucky now we have a national inherited cancer predisposition register that NHS England have set up with the National Disease Registration Service.  So that will enable us to capture individuals that have these sort of rarer but single gene disorders or conditions that increase the chance of developing blood cancers.  And that will enable us to do that sort of longer-term follow-up and get really more information.  We've touched on this already but I think there's really amazing research happening, why do some people develop blood cancers and some people don't, even though everyone carries the same underlying change that increases the risk?  And then I think really importantly, we're seeing now in some conditions, clinical trials of certain medications to see if that can actually prevent people who carry these inherited changes from progressing to developing blood cancers.  So I think all of those things are really exciting and will give us lots more information that we can then help patients and their families, particularly the sort of treatment and trials aspects.  Amanda: And, Sarah, on treatment and trials, how do think genomics might improve the treatment, but also the diagnosis of people with inherited blood cancers in the future?  Sarah: I think, you know, hopefully when we are able to accrue more information about these underlying genetic predispositions and how they actually then affect people's likelihood of developing blood cancer, we'll be able to build on what we have so far to make that just feel much more robust and evidence based.  And it feels like at the moment there are many of us struggling to bring together small threads of evidence that have been accrued in the UK but in other centres around the world that are also interested in understanding this inherited blood cancer risk.  In such a way that we can actually give patients and their families more clear information and advice about what that means to them.  And I think that in terms of the diagnosis of blood cancer, I think this is something that Bev alluded to.  If we could better understand who might benefit for example from having regular screening or monitoring blood tests performed to see whether we can detect an emerging blood cancer.  Versus identifying those people who actually, the chances of them developing a blood cancer are so small that doing those tests is likely to do them more harm than good.  Perhaps by just causing them to be anxious or have other sort of unintended consequences of that kind of testing.  So understanding something more about that natural history, as we've already alluded to, will hopefully improve our ability to go from the diagnosis of the predisposition condition to working out how to then diagnose the blood cancer on the back of that.  And with time, I think as Katie has alluded to, thinking about more specific treatments and more tailored treatments to the individual predisposition condition and the blood cancer.  So whether it's that you're intervening before the blood cancer has developed to try and reduce that happening, or whether it's that you're then treating the blood cancer after it's developed.  Understanding the genetic basis and what it is that causes that transition would be really helpful and I think that is something that will come but will take time.  And I think on a sort of national level what I would really hope to see over time is that we're able to use that improvement in evidence base to then be able to bring together perhaps more defined patient pathways.  So that if you're diagnosed with a particular condition, one of these leukaemia predisposition syndromes or another form of blood cancer predisposition, there's a recognised strategy and set of steps that should be taken for all of those patients.  To make sure that they're getting equity of care and make sure that everything is being done in a way that feels safe, sensible and appropriate across the country.  While still then enabling us to give really personalised treatment to that individual person and what that diagnosis means for them.  But I think until we've gathered more information and more evidence we are just in the process of trying to do that to then bring about those changes.   Amanda: If you enjoyed today's episode, we'd love your support.  So please subscribe, share and rate us on wherever you listen to your podcasts.  I've been your host, Amanda Pichini.  This podcast was produced by Deanna Barac and edited by Bill Griffin at Ventoux Digital.  Thank you for listening. 

In this episode of Hema Now, Anna Schuh discusses the evolution of precision medicine in haematology. From her early inspiration to pursue haematology to her pioneering work in chronic lymphocytic leukaemia, she reflects on how whole genome sequencing, single-cell technologies, and circulating tumour DNA are transforming risk prediction and treatment strategies.   Timestamps:   00:00 – Introduction  02:20 – What drew Anna to haematology  03:57 – Chronic lymphocytic leukaemia  08:55 – Genomics reshaping high risk chronic lymphocytic leukaemia  12:19 – OxPLoreD and STELLAR aims  15:52 – Liquid biopsies  19:56 – Global diagnostics implementation challenges  25:57 – Integrating molecular testing clinically  29:20 – Training future precision leaders  33:51 – Next breakthroughs in precision haematology  35:35 – Three magic wishes 

Right Thinking with Steve Coplon | Guests: Jim StovallThis week's show is called "Managing Expectations and Initiatives" with guest Jim Stovall. Tune in and hear Steve and Jim talk about how we control keeping our word by being more careful when we give our word.  Bestselling author, internationally renowned storyteller, Jim's wisdom has changed the lives of millions, and it will change your life too.https://www.talknetworkradio.com/hosts/right-thinking

The Health Minister won't say if the government has met its promise to blood cancer patients in New Zealand - that is that they have not been forgotten. Pharmac has proposed to fund two new combination medicines to treat a type of blood cancer - chronic lymphocytic leukaemia or CLL. The drugs can help those with CLL achieve longer lasting remission and avoid the need for traditional chemotherapy. Patients and advocates are celebrating, but Blood Cancer NZ and the Ministers acknowledge more work needs to be done. Lillian Hanly reports.

Two new blood cancer medications could soon be available to patients as pills, with one accessible through private clinics. Pharmac will consider funding treatments for chronic lymphocytic leukaemia, which could be available from May 1st. They can be taken in pill form and take away the need for chemotherapy. Blood Cancer NZ CEO Tim Edmonds told Ryan Bridge the medications take a targeted approach to first-line treatment, which means they'll be able to access targeted therapy instead of chemotherapy once diagnosed. He says instead of visiting the hospital up to 20 times in six months, they can take an oral tablet every day from home and actually get better outcomes. LISTEN ABOVE See omnystudio.com/listener for privacy information.

Right Thinking with Steve Coplon | Guests: Sonny EnglishThis week's show is called "The Message in the Music - Part 2" with guest Sonny English. Tune in and hear Steve and Sonny offer wisdom and encouragement to those of us needing to change our environment. After listening to this show, you will realize that there is much you can do to help your situation that you haven't been able to see before.https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon | Guests: Sonny EnglishThis week's show is called "The Message In The Music - Part 1 with guest Sonny English." Tune in and get inspired as you hear Steve and Sonny, a disabled army veteran, talk about staying positive through music. This show will warm your heart as you spend time with Sonny and experience what a beautiful person he is.https://www.talknetworkradio.com/hosts/right-thinking

ມູນນິທິ ມະເຮັງເລືອດຂາວ (The Leukemia Foundation) ເຕືອນວ່າ ເດັກນ້ອຍຫຼາຍກວ່າ 400ຄົນຕໍ່ປີ ອາດປະເຊີນກັບ ການກວດມະເຮັງເລືອດ (Blood cancer) ພາຍໃນສິບປີຂ້າງໜ້າ. ມູນນິທິ ກໍາລັງພະຍາຍາມຫາເງິນຈໍານວນ 12 ລ້ານໂດລາ ສໍາລັບການຄົ້ນຄວ້າ ແລະບໍຣິການຊ່ອຍເຫລືອ ຄອບຄົວທີ່ໄດ້ຮັບຜົນກະທົບ ຈາກໂຣກມະເລັງເລືອດ (Blood cancer) ຜ່ານໂຄງການ World's Greatest Shave, ດ້ວຍການຊຸກຍູ້ຜູ້ຄົນໃຫ້ແຖ, ຕັດ ຫລືຍ້ອມສີຜົມ ຂອງເຂົາເຈົ້າ ສໍາລັບ the World's Greatest Shave.

Send us a textIn this episode, Callie and Kraven sit down with two inspiring seniors, Jaeylynn Deutschman and Brennyn Treen, who are turning creativity into compassion. Through school fundraisers like Dimes for Donuts and the upcoming Winter Formal, they're rallying their classmates and community to raise money for Blood Cancer United - proving that small ideas can make a big impact. We talk about what motivated them to get involved, how student-led fundraising can spark real change, and what it feels like to leave a legacy of service in their final year of high school. It's a conversation about leadership, empathy, and the power of showing up for a cause bigger than yourself.For more information on their “Light the Fight” campaign, check out their link ⬇️ https://pages.lls.org/svoy/tol/svoynwoh26/KnightsLighttheFightThis episode was edited by Ace and sound recorded by Ollie S.Intro/Outro Music: “Motivated” by Alex MakesMusicDate Recorded: January 28th, 2026FOLLOW OUR SOCIALS:Twitter: @OHS_RoundTableInstagram: @ohs_roundtableEmail: podcast@otsegoknights.orgtiktok:  @ohs_roundtableStudent Video Show on YouTube: https://youtube.com/@lateknightsroundtablepodcast?feature=shared

Right Thinking with Steve Coplon.This week's show is called "Nine Years – A Message for the Ages." Tune in and hear Steve as he celebrates nine years of Right Thinking with Steve Coplon weekly shows and reflects on where he's been, who he is, and his new attitude about where he is now. This message gives a special thanks to Dr. Dennis Waitley and Jim Rohn, two of the most influential people in Steve's life who he has learned so very much from in his own personal development. This message will certainly bring you closer to finding your own purpose in life if you really listen.In this special episode titled "Nine Years, A Message for the Ages," I reflect on my transformative journey over nine years of hosting this podcast. I express my gratitude to influential figures such as Dr. Dennis Waitley and Jim Rohn for shaping my personal and spiritual growth. Sharing a poignant story from 1974, I describe my quest for adventure that led me to profound life lessons from a cowboy named Merle about love and connection. I also openly discuss recent health challenges, including my battle with cancer, and how they fostered resilience and a deeper perspective on life's seasons.Alongside significant literary influences, I emphasize the importance of nurturing connections and being present for one another, and of intentionally using our gifts to serve others. This episode serves as an inspiring call for listeners to embrace their unique paths with love and understanding.https://www.talknetworkradio.com/hosts/right-thinking

The Leukemia Foundation is warning more than 400 children a year could face a blood cancer diagnosis within the next decade. - Nagbabala ang Leukemia Foundation na mahigit 400 bata bawat taon ang maaaring ma-diagnose ng blood cancer sa loob ng susunod na dekada.

Right Thinking with Steve Coplon | Guests: Lefford Fate &  Henry SmithThis week's show is called "Toasting the Next Generation" with guests Lefford Fate and Henry Smith. Tune in and hear Steve welcome two of his favorite guests, Lefford Fate and Henry Smith. Lefford is a recipient of the Distinguished Toastmaster Award, the most prestigious award in Toastmasters International, signifying the highest level of educational and leadership excellence. Henry is one of the brightest lights of today's youth that Steve has the pleasure of knowing. Henry has recently joined Toastmasters, so it was a complete no-brainer for Steve to want to introduce Henry to Lefford. The timing is perfect for this meeting as Lefford will be launching his new book, Everybody Speaks, in the very near future. We are all going to become better speakers and communicators as we enjoy this powerful show.In this episode of "Right Thinking," I converse with Leffert Fate, a Toastmasters leader and author of "Everybody Speaks," and a young entrepreneur, Henry Smith. We discuss the impact of effective communication in leadership, personal expression, and the journey of finding one's voice.Leffert shares insights from his Toastmasters experience, while Henry reflects on overcoming public speaking nerves. We cover mentorship, practical speaking techniques, and the transformative power of community, reminding listeners that everyone has a story to share and urging them to communicate purposefully.https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon.This week's show is called "Poco a Poco. Tune in and hear Steve celebrate the 250th episode of Right Thinking with Steve Coplon as he shares some reflections on how little by little one goes far.https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon.This week's show is called "Lost and Found, Right from Wrong, A Lost Opportunity." Tune in and hear Steve share an amazing story of the recovery of a lost, then stole,n cell phone, and explore with him the deeper issue of doing the right thinghttps://www.talknetworkradio.com/hosts/right-thinking

Host Tricia Pritchard sits down with Sophia Cornetti to discuss how she and her classmates at Butler High School are raising money for blood cancer research.Welcome to Team B.o.S.S.'s Fundraising Page(1) Instagram

Right Thinking with Steve Coplon.This week's show is called "A New Year, A New Necktie." Tune in and hear Steve present a message for the New Year that is sure to get you thinking about how you can be glad you are alive and ready to make a contribution.https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon | Guest: Donna CoplonThis week's show is called "Why Listening Skills Are So Important" with Donna Coplon.  Tune in and hear Donna and Steve talk about the key to a healthy family is good communication, and good communication starts with good listening skills.https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon | Guest: Dave RichardsThis week's show is called "Choices: Choose to Take Charge of Your Life." Tune in and hear Steve and guest Dave Richards, CEO of Concursive Corporation, have an engaging conversation about one of the greatest of all human freedoms – the choice of one's attitude in any given set of circumstances. This show will motivate you to take charge of your life.https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon.This week's show is called "A Tribute to Jimmy Cliff." Tune in and hear Steve share a heartfelt tribute to Jimmy Cliff, one of Steve's favorite musicians, who was a pioneer in bringing reggae music to a world audience. Jimmy Cliff's message dealing with hardship, struggles, perseverance through challenges, and the faith to continue on had a profound influence on Steve. Through Jimmy Cliff's own lyrics, you will see why Steve loved Jimmy Cliff's music so much.In this episode of Right Thinking, I pay tribute to my musical inspiration, Jimmy Cliff, reflecting on his impact on reggae and resilience. I share my personal journey, sparked by watching "The Harder They Come," which ignited my passion for Jamaica and led to the creation of a travel agency concept tied to his music. I celebrate Cliff's ability to express struggles and social injustices through his lyrics, reading excerpts that highlight their motivational essence.My experiences at the Locken Music Festival and his live performance further cement his influence on my work with individuals in prisons, using his songs as tools for encouragement. Additionally, I explore how Cliff's legacy promotes themes of hope, love, and the universal fight against adversity, urging listeners to embrace these values as they navigate their own challenges.https://www.talknetworkradio.com/hosts/right-thinking

The Smart 7 is an award winning daily podcast, in association with METRO that gives you everything you need to know in 7 minutes, at 7am, 7 days a week...With over 19 million downloads and consistently charting, including as No. 1 News Podcast on Spotify, we're a trusted source for people every day and the Sunday 7 won a Gold Award as “Best Conversation Starter” in the International Signal Podcast Awards If you're enjoying it, please follow, share, or even post a review, it all helps...Today's episode includes the following guests:Anthony Albanese - Australian Prime Minister Julie Inman Grant - Australia's ESafety Commissioner Dr Rachel Murrihy - Clinical Psychologist and Director of the KIdman Centre at Sydney's University of Technology Melanie Dawes - Chief Executive of Content Regulator Ofcom Lisa Nandy - UK's Culture Secretary Will Guyatt - The Smart 7's Tech Guru Reid Wiseman - NASA astronaut and member of Artemis crew Dr David Burtt - Postdoctoral Fellow at NASA's Goddard Space Flight CentreDr Mike Thorpe - Assistant Research Scientist at the University of Maryland, and the Planetary Environments Lab Division at NASADouglas Gonzaga de Sousa - Co-ordinator of the Centre for Specialty Coffees of Espirito SantoEdmond Rhys Jones - Co-lead at Boston Consulting Groups Centre for Climate and Sustainability Policy & RegulationBill Gates - Co-founder of Microsoft and high profile philanthropist Alyssa Tapley - Took part in the gene therapy trialProfessor Waseem Qasim - Consultant in Paediatric Immunology, and Professor of Cell and Gene Therapy at UCLDr Robert Chiesa - Consultant in Bone Marrow Transplantation at Great Ormond Street HospitalDr Roberto Biaggi - Co-author of the study from California's Loma Linda University.Celso Aguilar - Superintendent of the Toro Toro Park in BoliviaContact us over @TheSmart7pod or visit www.thesmart7.com or find out more at www.metro.co.uk Presented by Ciara Revins, written by Liam Thompson, researched by Lucie Lewis and produced by Daft Doris. Hosted on Acast. See acast.com/privacy for more information.

Right Thinking with Steve Coplon | Guest: Henry SmithThis week's show is called "Get Up Off the Couch!" with guest Henry Smith. Tune in and hear Steve and Henry provide powerful inspiration on why it is so important to believe in yourself so that you can set sail on your life's journey and not be stuck in someone else's vision for you. Steve and Henry will help you learn to apply yourself to live up your potential to give you the best chance to achieve your goals in life.In this episode of Right Thinking with Steve Coakland, I chat with young entrepreneur Henry Smith about the power of self-belief in achieving personal success. We discuss his journey from feeling lost to becoming proactive, emphasizing the importance of evaluating one's environment and relationships.Using Snoop Dogg's rubber band analogy, we highlight how the right connections can propel us forward. We also explore the values of integrity and self-discipline, the necessity of embracing failure, and the importance of adaptable goals. This episode serves as a powerful reminder that taking action is essential to shaping one's own destiny.https://www.talknetworkradio.com/hosts/right-thinking

Concentrating on Priorities | Episode #459This week's show is called "Concentrating on Priorities." Tune in and hear Steve share his heart on what keeps him going every day. For Steve, it all comes down to knowing what is important and a deep commitment to serving others. It all starts with being thankful for each and every day that the Lord has blessed him with.In this episode, I explore the theme of prioritizing what truly matters, focusing on gratitude after Thanksgiving and the personal significance of this holiday in my battle with multiple myeloma. I share my tradition of sending heartfelt cards to loved ones, fostering meaningful connections, and reflecting on life's purpose through mentoring.Citing Marcus Aurelius, I emphasize the role of daily habits in character building and the impactful message of unity from "We Are the World." My goal is to inspire listeners to embrace their worth, act kindly, and cultivate a sense of community and gratitude.https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon.This week's show is called "Thankfulness." Tune in and hear Steve share his thoughts on why he is so thankful for the life that he has, particularly at this Thanksgiving time of the year, and how you too can be just as thankful.https://www.talknetworkradio.com/hosts/right-thinking

When doctors couldn't cure John Belfonte's blood cancer alone, family stepped in — and saved his life. Up next, the powerful story of how love, science, and one selfless act led to a cure.

Right Thinking with Steve Coplon | Guest: Henry SmithThis week's show is called 95 Years of Entrepreneurial Experience" with guest Henry Smith. Tune in and hear Steve and Henry, founder/owner of Smashers Burgers & Fries, have an engaging conversation on what it takes to operate a small business. With over 95 years of combined wisdom to draw from, Steve and Henry will benefit you greatly. Whether you are already in business for yourself, going to someday operate your own business, or just want to learn more about how to give yourself a better chance of success in your life, this show is for you.In this episode of Right Thinking with Steve Coplon, I speak with Henry Smith, the founder of Smashers Burgers and Fries. We explore the realities of running a small business in the food industry, drawing from our combined 95 years of entrepreneurial experience. Henry shares his journey into restaurant ownership, highlighting the importance of understanding costs and making strategic decisions.We discuss his innovative use of social media for marketing, focusing on video engagement to build brand awareness. Key themes include the significance of hard work, persistence, and customer feedback in enhancing the business. The conversation reflects on personal growth and resilience, emphasizing that the entrepreneurial journey is as crucial as the financial outcome.https://www.talknetworkradio.com/hosts/right-thinking

In this inspiring episode of Philanthropy in Phocus, Tommy D – the Nonprofit Sector Connector – sits down with his longtime friend Dr. Joy DeDonato, Executive Director for the Metro New York region of Blood Cancer United (formerly the Leukemia & Lymphoma Society). Joy shares how a lifetime of service began with a simple feeling of wanting to help others, and evolved into more than two decades in the nonprofit sector focused on cancer support, education access, women's issues, and amplifying the voices of those who are too often unseen or unheard. She reflects on the powerful example set by her parents, who modeled service “before it had a title,” and how that foundation of love, grit, and doing the right thing has shaped her entire journey.Joy walks listeners through her professional path from Nassau Community College—first as a student, then staff member and later Executive Director of the college's foundation—to a decade at the American Cancer Society, and on to SUNY Stony Brook working on women's health and women's leadership. Throughout, she emphasizes the power of long-term relationships, showing how mentors, colleagues, and friends have stayed connected across roles, institutions, and life milestones. Joy also shares deeply personal stories of losing loved ones to cancer early in her career, and then, 20 years later, watching close family members with blood cancers move from “despair to hope to strength” thanks to advances in treatment—an evolution that called her back into the cancer space and ultimately to Blood Cancer United.Together, Tommy and Joy highlight the recent rebrand from Leukemia & Lymphoma Society to Blood Cancer United, designed to be more inclusive of all blood cancer patients and families. Joy outlines key initiatives including the Dare to Dream project for safer pediatric treatments, the Student Visionaries of the Year campaign, the emotional Light the Night walks, the Big Climb at Citi Field, and the Visionary of the Year competition that rallies leaders to raise critical funds. She also touches on her wider civic leadership as Vice Chair of Dress for Success Long Island and as a commissioner for both Human Rights and Women's Leadership in Suffolk County. Through humor, Golden Girls and Fraggle Rock references, and real talk about grit and service, this episode celebrates how one person's commitment to community, equity, and compassion can ripple out to transform countless lives.

Right Thinking with Steve Coplon.This week's show is called "Personal Finance and Small Business Ownership Part 4 - Encore Edition #19". Tune in and hear Steve as he continues in the last of this four-part series to teach valuable lessons on how to reach success in business. Now that you've established your Sales Goals, your best chance to reach them is with a well-managed Marketing Plan.https://www.talknetworkradio.com/hosts/right-thinking

There are calls for greater transparency about how Pharmac prioritises medicines on what is effectively a wait list for funding as it considers culling that list. If the proposal goes ahead the government drug buying agency will focus on cutting drugs that have been in the lowest ranked group on the options for funding list for more than two years. Publicly drugs on the funding wait list appear in alphabetical order; but where they are ranked in terms of priority for funding is kept secret. Leukemia and Blood Cancer chief executive Tim Edmonds spoke to Lisa Owen.

Right Thinking with Steve Coplon.This week's show is called "Personal Finance and Small Business Ownership Part 3 - Encore Edition #17." Tune in and hear Steve as he continues to teach this powerful seminar on starting your own business.  If you are going to succeed in owning your own small business, you need to know your costs and expenses and how much sales you need to cover them and pay yourself!https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon.This week's show is called "Personal Finance and Small Business Ownership  - Part 2 | Encore Edition #16." Tune in and hear Steve as he continues to share valuable insights and provide tools on how to give yourself the best chance of success if you are thinking about starting your own small business.https://www.talknetworkradio.com/hosts/right-thinking

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare blood cancer that primarily affects older adults. One of the key challenges in diagnosing and treating BPDCN is that it closely resembles other forms of leukemia in both appearance and behavior. This overlap often leads to delays or uncertainty in diagnosis, especially since currently there is no single, reliable marker that clearly distinguishes BPDCN from related diseases. To address this issue, researchers from the City of Hope Comprehensive Cancer Center investigated the genetic profile of BPDCN. Their study, titled “Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience,” was published in Oncotarget (Volume 16). Full blog - https://www.oncotarget.org/2025/10/22/genetic-study-identifies-potential-diagnostic-marker-for-rare-blood-cancer-bpdcn/ Paper DOI - https://doi.org/10.18632/oncotarget.28742 Correspondence to - Michelle Afkhami - mafkhami@coh.org Abstract video - https://www.youtube.com/watch?v=wUjr3uU3onI Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28742 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, Blastic plasmacytoid dendritic cell neoplasm (BPDCN), Next-generation sequencing (NGS), CCDC50 To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Right Thinking with Steve Coplon.This week's show is called "Personal Finance and Small Business Ownership -  Part I."   If you have ever thought about starting your own small business, then this show is for you!https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon.This week's show is called "Row, Row, Row Your Boat." Tune in and hear Steve share valuable insights into one of the strongest core parts of his character and personality – Perseverance. Believing in yourself and knowing that you have reasons to not give up, will motivate you toward success. Stay tuned in till the end of this powerful show and learn what motivates Steve.In this episode of Right Thinking, I delve into perseverance through personal stories, particularly my journey battling COPD and the lessons learned from cardio rehabilitation. Titled "Row, Row, Row Your Boat," I highlight the importance of steady progress and community support in overcoming challenges.Drawing parallels between rowing and life, I discuss resilience and the significance of acceptance in the face of setbacks. Using quotes from influential figures, I encourage listeners to reflect on their own journeys and find motivation in family and community. The episode emphasizes that persistent effort and a positive mindset are essential for navigating life's obstacles.https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon.This week's show is called "450 Thole Street - Part 2." Tune in and hear Steve continue the journey back to his first neighborhood. A neighborhood that was a true community, where neighbors knew one another and watched out for one another. It will take you back to your own roots. The visit will help you find the peace and understanding that we are all searching for.In this episode, I continue my reflections on 450 Tholl Street, a neighborhood rich with memories of community and connection. Joined by my sister Arlene, we share anecdotes that highlight the warmth and camaraderie of our upbringing, emphasizing the importance of storytelling in honoring those who shaped our lives. We delve into the invaluable life lessons learned from neighbors, illustrating how their support during both joyful and challenging times influenced our resilience.As I discuss my family's trials, I underscore the compassion shown by our community. Together, we explore the interplay of light and dark in my childhood, including the significance of literature in shaping perspectives. I draw connections between my experiences and spiritual teachings, encouraging listeners to find strength in their own histories and communities, ultimately trusting in the divine plan that guides us.https://www.talknetworkradio.com/hosts/right-thinking

Right Thinking with Steve Coplon.This week's show is called "450 Thole Street".  Tune in and hear Steve as he invites you to travel with him back to his first neighborhood where it all really began for him. This prequel to his autobiography "The Value of a Dollar: My Memoirs and How I Learned the Work Ethic", offers insights into understanding how Steve grew up to be the man that he is. Take a look into Steve's life, take a look into your own. There's always more to learn.In this episode, I delve into my childhood memories, specifically my first neighborhood, Thole Street, as a prelude to my autobiography, "The Value of a Dollar." I share personal stories that reveal how my early experiences shaped my identity and relationships. With a focus on family dynamics, I discuss the complexities of growing up amidst confusion and conflict while highlighting the importance of understanding our roots for personal growth.Through anecdotes about neighbors and friendships, I illustrate how these formative experiences fostered resilience and community support. I stress the significance of reflection and forgiveness, encouraging listeners to evaluate their pasts and the lessons learned along the way. By the end, I hope to inspire a journey of self-discovery, urging everyone to reconnect with their memories to better understand their present selves. Join me next week as we continue this exploration of identity and growth.https://www.talknetworkradio.com/hosts/right-thinking

Dr. Anders Kolb on Leading Blood Cancer United Into a New Era by Managed Care Cast

According to Blood Cancer United (formerly the Leukemia & Lymphoma Society), approximately every 3 minutes, 1 person in the United States is diagnosed with leukemia, lymphoma, or myeloma. AML is a heterogeneous hematologic malignancy; despite advances in treatment, AML remains challenging to cure. Integrating new treatment options for patients with refractory acute myeloid leukemia (AML), including menin inhibitors, into routine oncology care can help bring novel therapies to patients with relapsed or refractory AML. ACCC is committed to providing information on the latest research and treatment options for blood cancer. In this episode, CANCER BUZZ speaks with Keri Halsema, NP, MSN, RN, nurse practitioner in the Blood Disorders Center at the University of Colorado Anschutz about the factors that influence treatment choices and the use of menin inhibitors to treat relapsed or refractory AML.   “We, as clinicians, are really excited that we have another treatment choice with respect to targeted therapy in these patients that have either the KMT2A rearrangement or the NPM1 mutation…Having outreach and making sure that community oncologists are aware that these medications are available, that various academic centers have various clinical trials that patients may qualify for and may be enrolled in, that's something that's very important in moving care forward for these patients with AML.” – Keri Halsema, NP, MSN, RN   Keri Halsema, NP, MSN, RN Nurse Practitioner Blood Disorders Center University of Colorado Anschutz Aurora, CO   Resources: Menin Matters   ACCC Hematologic Malignancies   ACCC AML Resource Page   ACCC Educational Video: Best Practices and Solutions for Performing Bone Marrow Biopsies in AML Care   Leukemia & Lymphoma Society Facts and Statistics   Menin inhibitors in the treatment of acute myeloid leukemia

Right Thinking with Steve Coplon | Guest: Henry SmithThis week's show is called "A Smashing Success" with guest Henry Smith. Tune in and hear Steve interview Henry, a young, budding entrepreneur, and know why Steve firmly believes that the future is safe with rising stars like Henry securing the future. You will be captivated when you hear what Henry is doing with his life and how he got there.In "A Smashing Success," Steve Copelan interviews Henry Smith, a 21-year-old entrepreneur and founder of the burger restaurant Smashers. Henry shares his journey from experimenting with burger recipes during the COVID-19 pandemic to launching a successful food truck and restaurant.The discussion emphasizes financial literacy for youth, highlighting Henry's plans to incorporate educational initiatives into his business. They also explore themes of work ethic, mentorship, and community service, advocating for the skills and potential of younger generations. The episode concludes with an optimistic outlook on the impact of young leaders like Henry.https://www.talknetworkradio.com/hosts/right-thinking

There are calls for the government to settle an unpaid debt, a promise made by National to blood cancer sufferers, desperate for access to drugs not funded in Aotearoa. On the election campaign, National pledged to fund a list of medications for solid cancer tumours. It was forced to make good on that, following public backlash over a lack of action. But it had also given assurances about closing the medicine gap for blood cancer patients too, yet two years on they're still dying for it to deliver.

Prior to the election, Christopher Luxon made a commitment to fund a list of hard tumour cancer medications. At the same time National repeatedly promised that blood cancer sufferers would not be forgotten. But two years on from that promise, many of them do feel forgotten. The drug Daratumumab, or Dara is on Pharmac's priority drug list. That's the list of drugs it would like to fund, but can't afford. Dara is virtually free in Australia, but costs hundreds of thousand of dollars here. That means some desperate blood cancer patients are funding it themselves; relying on the kindness of others and donation pages. Aucklander Geoff Dawson, has multiple Myeloma, and is on Dara, he spoke to Lisa Owen.

At the Society of Hematologic Oncology 2025 Annual Meeting, CancerNetwork® spoke with a variety of experts about notable clinical developments and trial results across the hematologic oncology landscape. Throughout the meeting, clinicians and researchers discussed the latest data and initiatives in myelofibrosis, multiple myeloma, lymphoma, and other types of blood cancer. Francesca Palandri, MD, PhD, an adjunct professor in the Department of Medical and Surgical Sciences at the University of Bologna in Bologna, Italy, shared insights from a session focused on exploring predictive markers for the efficacy of ruxolitinib (Jakafi) among patients with myelofibrosis.1 Noting variance in response rates as well as possibilities of disease progression or treatment discontinuation associated with ruxolitinib, Palandri emphasized the importance of assessing predictors of response to better orient clinical decision-making strategies regarding the agent's use. She also highlighted how factors such as cytopenic phenotype, higher peripheral blast counts, and higher burden of disease may impact response rates and survival among patients. Additionally, Sundar Jagannath, MD, a professor of Medicine specializing in hematology and medical oncology at the Icahn School of Medicine at Mount Sinai and The Tisch Cancer Institute, spoke about his presentation on potentially defining a cure in the management of multiple myeloma.2 He described the importance of “chang[ing] the dialogue” in multiple myeloma to give hope to patients and encourage physicians to engage in patient care more optimally. By defining a cure in multiple myeloma, Jagannath stated, it may be possible to offer more finite durations of treatment and stop therapy with the confidence that patients will not relapse. Finally, Adam J. Olszewski, MD, an associate professor of medicine at The Warren Alpert Medical School of Brown University, discussed his work on the phase 3 SUNMO trial (NCT05171647).3 Findings from this presentation showed that mosunetuzumab-axgb (Lunsumio) plus polatuzumab vedotin-piiq (Polivy; M-Pola) reduced the risk of progression or death by 59% vs rituximab (Rituxan) with gemcitabine and oxaliplatin (R-GemOx) in relapsed/refractory large B-cell lymphoma (LBCL). Olszewski also outlined next steps for refining treatment strategies in this patient population. References Palandri F. Predictive markers for ruxolitinib in MF. Presented at the Society of Hematologic Oncology 2025 Annual Meeting; September 3-6, 2025; Houston, TX. Jagannath S. Is it time to say “CURE” in multiple myeloma? Presented at the Society of Hematologic Oncology 2025 Annual Meeting; September 3-6, 2025; Houston, TX. Westin J, Zhang H, Kim W, et al. Mosunetuzumab plus polatuzumab vedotin is superior R-GemOx in transplant-ineligible patients with R/R LBCL: primary results of the phase III SUNMO trial. Presented at the Society of Hematologic Oncology 2025 Annual Meeting; September 3-6, 2025; Houston, TX. Abstract ABCL-1492.

Right Thinking with Steve Coplon.This week's show is called "Having Something in Your Back Pocket." Tune in and hear Steve talk about how having something to fall back on will help you keep the good fight going.https://www.talknetworkradio.com/hosts/right-thinking

In this special episode of The Bloodline, we introduce our new name and what it means for blood cancer patients, […] The post We are Blood Cancer United: a new name, an unstoppable community first appeared on The Bloodline with Blood Cancer United Podcast.

The Leukaemia Foundation says one in 12 people in Australia is at risk of being diagnosed with blood cancer. Still, a lack of awareness about symptoms means many cancers go undiagnosed for longer periods. Sydney-based GP Prabin Pathak spoke to SBS Nepali about symptoms and precautionary measures people can take. This audio has been updated due to an inadvertent technical error earlier. - लुकिमिया फाउन्डेसनले अस्ट्रेलियामा १२ मध्ये एक जनालाई रक्त क्यान्सर हुने जोखिम रहेको बताउँदै गर्दा, यसका लक्षणहरू बारे जागरूकताको कमी हुँदा धेरै मानिसहरू यस्ता क्यान्सरहरू लामो समयसम्म पत्ता नलाग्ने अवस्थामा पुग्ने गरेका छन्। सेप्टेम्बर महिनालाई रगतको क्यान्सरसँग सम्बन्धित रहेर जनचेतना अभिवृद्धि गर्ने महिनाका रूपमा लिने गरिन्छ। यसै अवसरमा अस्ट्रेलियामा ‘साइलेन्ट किलर' पनि भनिने रगतसँग सम्बन्धित क्यान्सरको अवस्था र उपचारको व्यवस्था चाहिँ कस्तो छ त? रक्त क्यान्सरका लक्षण र सतर्कताका लागि अपनाउन सकिने उपायहरूका बारेमा, सिड्नीस्थित एक जीपी प्रबिन पाठकसँग, एसबीएस नेपालीले गरेको कुराकानी सुन्नुहोस्। नोट: प्राविधिक गडबडीका कारण यो पोडकास्ट पहिले प्रकाशित हुँदा अरू नै सामाग्री बजेकोमा हामी क्षमाप्रार्थी छौँ।

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In this episode, host Jonathan Sackier is joined by Andrew Dunbar, Assistant Professor in the Department of Hematopoietic Biology and Malignancy at the University of Texas MD Anderson Cancer Center, Houston, USA. Dunbar discusses his research into myeloproliferative neoplasms, what drives disease progression and resistance, and promising targets for treatment, while reflecting on the mission of his lab and what lies ahead for the field.  Timestamps  00:00 – Introduction  02:29 – One thing people should know about myeloproliferative neoplasms  05:01 – Dunbar's background and research focus  08:00 – What would Dunbar do if not science and medicine?  10:24 – The basics of myeloproliferative neoplasms  14:30 – Myeloproliferative neoplasm diagnosis and treatment  16:49 – What drives disease progression and resistance?  18:30 – The mission of Dunbar's lab  21:23 – Development of AJ1-11095  22:54 – Balancing the complexity of disease modelling with urgent clinical needs  24:03 – Promising targets and pathways  26:35 – What's on the horizon?  28:40 – Three wishes 

Alexandra Wilson passed away just 10 months after being diagnosed with Acute Lymphoblastic Leukemia in March of 2002, from this Blood Cancer that normally has a very high cure rate. Her twin sister Arianna will talk about her sister and about her role as the now official Executive Director of the Alex's Team Foundation which was named in Alexandra's honor, and helps in many ways the cause of Pediatric Cancer, with an emphasis on the Pediatric Cancer Nursing Community. 

It's a big day at WCCO, a whole day (6a-6p) dedicated to raising money for NMDP as they fight blood cancers and disorders and aim to create a world where every patient can receive their life-saving cell therapy. Jason and Dan are live at NMDP and are joined by Brent Frederick from Jester Concepts and Ethan Walsh and his family . NMDP is a global nonprofit leader in cell therapy, helping save the lives of patients with blood cancers and disorders.