PodMed TT

Program notes:0:35 Screen time trajectories in adolescents1:33 31% had increasing addictive use trajectories2:31 Females more involved in social media3:06 Cannabis and CV risk4:06 Smoking or using other products5:06 Mechanisms include oxidative stress6:06 Haven't regulated6:28 Tau PET imaging in Alzheimer's7:28 90% of tau positivity concurs with AB8:30 Will blood test obviate?9:30 Imaging to detect spread9:43 CT perfusion for death by neurological criteria10:43 Validation threshold 98%11:43 Maybe adding another technique12:43 End

This week's topics include family affluence and telomeres in children, gut bugs and respiratory illness in children, heat illness and homelessness, and low potassium diets and hypertension and diabetes.Program notes:1:05 Heat illness and homelessness2:05 No access to water3:05 More likely in southern states3:20 Telomere length, family affluence and cortisol4:20 High affluence had longer telomeres5:20 Cortisol may need to be measured over longer time interval6:20 Dietary patterns, sodium reduction, hypertension and those with diabetes7:20 Dash-D with low sodium8:20 Low sodium is good9:14 Neonatal gut microbiota and lRTIs10:14 Half of children born vaginally11:15 First to look in newborns12:39 End

This week's topics include treating hot flashes in breast cancer survivors, a blood test for detecting colorectal cancer, exercise to improve survival after colorectal cancer treatment and CAR-T therapy for solid tumors.Program notes:0:40 CAR-Ts for solid tumors1:40 Advanced gastric or gastroesophageal cancer2:40 Cytokine release syndrome3:22 Exercise after treatment for colorectal cancer4:23 Disease free survival superior5:23 Currently not much exercise6:23 Potential mechanisms7:10 Treating hot flashes in breast cancer survivors8:10 Neurokinin receptors9:12 A blood test to screen for colorectal cancer10:12 Asymptomatic adults11:12 Will not replace FIT or screening colonoscopy12:12 Survival advantage due to polypectomy13:19 End

This week's topics include the worldwide burden of skin cancers, risk of a second stroke when a person is taking anticoagulants, patients supporting each other for weight loss maintenance, and imaging for dense breasts.Program notes:0:45 Dense breast tissue imaging1:40 MRI and contrast enhanced mammography superior2:40 Giving IV contrast with mammography2:53 Burden of skin cancer in older adults worldwide3:52 Greater disease burden in men4:53 More likely to have exam and biopsy5:48 Atrial fibrillation, recurrent stroke risk and anticoagulants6:50 One in six will recur7:50 Atrial appendage occulsion?8:20 Patient delivered weight loss management9:20 Five percent or greater initial weight loss10:20 Reduced the amount of weight regain11:22 Much less than a professional's care12:49 End

This week's topics include treating resistant hypertension, gabapentanoids and the risk of self harm, risk for depression after diagnosis of a medical condition, and fatty liver and pregnancy.Program notes:0:35 Depression after medical condition diagnosis1:36 Any of a number of medical conditions2:37 A much lower risk in comparison group3:37 Major depressive disorder could be number one cause of YLL4:01 Fatty liver and pregnancy outcomes5:01 Matched to those with obesity or T2D6:01 Screening general population not indicated7:00 Gabapentanoids and risk of self harm8:01 Rates of self harm variable 9:04 Use has increased fourfold10:00 Treatment of resistant hypertension11:01 Spironolactone or amiloride12:33 End

This week's topics include USPSTF on screening for syphilis in pregnancy, when to take blood pressure medicines, comparing weight loss drugs, and a narrative intervention for PTSD after an ICU stay.Program notes:0:40 NEJM publication of comparison of obesity medications1:40 Tirzepatide versus semaglutide for 72 weeks2:41 Also had reduction in blood pressure3:26 Rise in congenital syphilis and screening4:26 Disparities among various groups5:26 Highest incidence in the last 30 years6:26 In 2023 210,000 cases of syphilis7:00 When to take blood pressure meds8:00 Monitored blood pressure in a subset8:40 Intervention for PTSD after ICU stay9:40 Self reported PTSD symptoms​​10:40 Must learn to deliver intervention11:40 Physician needed to spend 45 minutes per visit12:42 End

Program notes:0:40 Covid and flu vaccine1:40 More immunogenic response2:40 Female urinary incontinence treatment3:40 Mid urethral sling or botox4:40 Doesn't require surgery5:40 Combined therapy group6:10 Large language models and discharge summaries7:10 100 hospital encounters 8:10 Maybe provides a draft9:00 AI and diagnosing diabetic kidney disease10:01 Large number of retinal images to train11:01 Can actually see blood vessels12:29 End

Program notes:0:47 Gun injuries and deer hunting season1:47 Other associated injuries2:47 Coincidence of hunting?3:48 Restrict hunting guns to that use4:10 Can we avoid surgery in some with cancer?5:10 Dostarlimab treatment6:10 Can help avoid surgery in few who have this mutation7:10 Look at specific pathways7:30 Lung cancer treatment8:32 71% responded9:12 Impact of Pepfar funding freeze10:12 Looked at waiver scenarios11:12 Decreased deaths and infection12:13 Takes time to resume13:06 End

Program notes:0:40 Polygenic risk score for prostate cancer1:40 90th percentile or higher2:40 Genetic risk for cancer3:41 Avoid false positives4:00 Cervical artery dissection and subsequent stroke risk5:00 High in older people, Black and Hispanic people6:00 Nonspecific symptoms may predict7:00 Preventing clotting in patients with cancer8:00 Standard dose followed by half dose8:44 USPSTF on supporting breastfeeding9:45 Support systems not that good10:55 What is the best strategy to support?12:14 End

Program notes:0:33 TAVR outcomes improved1:33 Dapagliflozin 2:33 Looked at comorbidities3:00 Tolebrutinib for relapsing MS4:00 Annualized relapse rate5:00 Works in the CNS6:00 First endpoint wasn't proven6:20 Invasive group A strep7:20 Become more resistant to antibiotics8:01 Not a single type of group A strep8:25 Hearing loss and heart failure9:25 Psychological distress mediiates10:25 With hearing aids, you would think it would go down11:20 Everything looks associated12:03 End

This week's topics include aging and diet, blood based biomarkers for dementia, ten and thirty year risk for cardiovascular disease, and global effect of cardiovascular risk factors.Program notes:1:00 Five factors and cardiovascular disease2:00 Additional life years free of CVD3:00 Irrespective of where you live3:27 Optimal dietary patterns for healthy aging4:28 Higher intake of fruits, vegetables5:28 Little bit better one or another6:28 Can actually change this6:40 Ten and thirty year CVD risk7:40 Risk at ten and thirty years disparate8:40 Increased cholesterol or blood pressure9:20 Blood based biomarkers10:20 Dementia free adults11:20 Risk low with none of the factors12:27 End

This week's topics include a better way to treat A-fib, managing bleeding in cardiac surgery, penicillin for strep infections, and treating pulmonary hypertension.Program notes:0:55 Ablation for afib1:51 Pulsed field ablation PFA2:55 Training physicians3:23 Prothrombin complex versus frozen plasma4:24 Noninferiority outcome5:24 Documented bleeding issue6:25 New treatment for pulmonary hypertension7:25 Improve outcomes in advanced disease8:25 Well tolerated8:40 Penicillin lowest dose to prevent pharyngitis9:40 To avoid 8.1 ng/ml steady state10:40 Get secondary prophylaxis12:10 End

This week's topics include cell signatures in PCOS, a new technique for prostate biopsies, improving the safety of carotid endarterectomy, and long term risk after TIA .

This week's topics include cell signatures in PCOS, a new technique for prostate biopsies, improving the safety of carotid endarterectomy, and long term risk after TIA.0:41 Long term risk of stroke after TIA1:39 About one in five over the next ten years2:40 Need to continue antiplatelet agents3:33 New technique for prostate biopsy4:36 Biopsy naive men5:35 Microultrasonography used6:35 Limited availability of MRI7:33 Improving safety of carotid endarterectomy8:33 Sonolysis used9:34 Safe and routinely available9:40 Single cell characterization of PCOS endometrium10:40 Cells harvested during proliferative phase11:40 PCOS causes increased risk of endometrial cancer12:54 End

This week's topics include an insulin pump for type 2 diabetes, nudges for critical care physicians, statins and liver disease, and rates of Parkinson's disease worldwide.

This week's topics include AI for mental illness, maternal death worldwide, CVD, education and income in the US, and sleep spindles and regain of consciousness.

This week's topics include implications of protein S, endothelial cell genetic assessment and lipid lowering, cardiac rehab on an app, and vitamin D and respiratory infectious disease.

This week's topics include genetic and environmental contributions to aging and mortality, diet during pregnancy for gestational diabetes, telemedicine and low value medical tests, and vitamin D and respiratory infectious disease.

This week's topics include predicting preeclampsia, improving ablation for atrial fibrillation, wastewater surveillance in aircraft for infectious disease, and platform trials for ALS treatments.

This week's topics include patient reported symptoms in advanced cancer management, the impact of remnant cholesterol, TIAs, and blood markers for AD and other dementias.

This week's topics include staving off cognitive decline, prehabilitation, age, sex, and diabetes treatments, and putting type 2 diabetes into remission..

This week's topics include neuropathy after chemotherapy, a comprehensive approach, to dementia care, mortality and falls, and life expectancy and educational attainment.

This week's topics include a polygenic risk score and COPD, an antibody to reduce bleeding risk in those with AFIB, aspirin use in cardiovascular risk reduction, and best treatments for local esophageal cancer.

This week's topics include palliative care in the ED, attempting to improve outcomes in large strokes, lung and associated cancers worldwide, and eyeing risk factors for stroke.

This week's topics include catheter material for PICC lines, a diabetes medication for kidney stones, driver mutation clearance and relapse prediction, and exercise and heart failure.

This week's topics include warming mittens for hand osteoarthritis, pediatric firearm and motor vehicle fatalities, buprenorphine in young adults with opioid use disorder, and electronic cigarettes and respiratory symptoms.

This week's topics include taxi driving and risk for Alzheimer's, fairy tales and sleep, manual dexterity in hospital workers, and AI and cognitive impairment.

This week's topics include electronic nudges for flu shots, reducing plaques in coronary arteries, electronic sepsis alerts, and managing cachexia in people with cancer.

This week's topics include lead exposure and mental disorders, assisted dying, depression treatment after positive screening in primary care, and chocolate and Type 2 diabetes.

This week's topics include Medicare negotiation on drug price comparison, messaging to improve adherence to CVD medications, maternal cancer detection, and VILPA.

This week's topics include reducing the dose of pneumococcal vaccine, benefits of HPV vaccination, treatment of metastatic colorectal cancer, and suitability for treatment with obesity drugs.

This week's topics include genetic testing of couples planning pregnancy, use of two medications in people who've had a heart attack, genome-wide association models and risk for cardiovascular disease, and two medicines to reduce lipoprotein(a).

This week's topics include the impact of lipoprotein A, frailty as a predictor of dementia, a diabetes medicine in kidney stones and gout, and the impact of multiple chronic medical conditions on hospitalization and death.

This week's topics include very early medication abortion, predicting who needs a defibrillator after MI, removal of IVC filters, and early sugar exposure, hypertension and diabetes.

This week's topics include fans and core body temperature, strategies to help patients with prescription drug prices, hearing loss and Parkinson's, and oral health, frailty and death.

This week's topics include metformin and congenital abnormalities, best meds for opioid use disorder treatment, deprescribing for patients with dementia, tobacco use among U.S. youth.

This week's topics include transplanting kidneys from HIV+ donors; identifying who's at risk for preeclampsia; rainfall and mortality; and a new agent for MASH.

This week's topics include a report on cancer in the U.S., MRI and prostate cancer diagnosis, ultraprocessed foods and diabetes risk, and happy moods and happy hearts.

This week's topics include youth, opioids and EMS, good news for women with triple-negative breast cancer, a lack of benefit of rapid malaria tests, and risk related to high-dose amphetamines in adults with ADHD.

This week's topics include emissions from inhalers, time to reimbursement for drugs from approval, behavior after a false-positive mammogram, and RSV vaccination and hospitalization.

This week's topics include semaglutide and mortality, beta blockers after MI, FIT test comparison, and 30-year CVD prediction with a blood test in women.

This week's topics include myocarditis after COVID-19 vaccination, a new medicine for menopausal symptoms, heat-related deaths in the U.S., and wastewater surveillance for predicting COVID outbreaks.

This week's topics include tranexamic acid for liver resection, EDTA for chelation therapy, suicidality among spouses of people with cancer, and do amino acids protect kidneys during surgery.

This week's topics include mortality rates in Anglophone countries, computer interfaces for communication in people with ALS, plant and animal fat and mortality, and skin reactions to antibiotics.

This week's topics include methotrexate for knee osteoarthritis, impact of new CVD risk calculator, blood tests for Alzheimer's, and evaluating squamous cell cancers.

This week's topics include smoking and semaglutide, fatal and nonfatal firearm injuries, bilateral mastectomy, and HIV in women.

This week's topics include a monoclonal antibody for ulcerative colitis, the impact of cash payments on health care utilization by low-income people, an AI model to manage diabetes, and sleep and chronic disease.

This week's topics include nasal sprays and URIs, Paxlovid in prevention, endometriosis and ovarian cancer, and diabetes after COVID-19.

This week's topics include a new agent to help prevent kidney transplant rejection, more effective medications to reduce kidney disease and CVD in people with diabetes, use of nicotine pouches nationally, and acceptability of hospital-at-home care.

This week's topics include avoiding chemotherapy-induced neuropathy, predictive value of screening EKGs, use of medicines to treat opioid use disorder, and trends in CVD in the U.K.

This week's topics include six biotypes for anxiety and depression, overuse of aspirin for primary prevention, managing gestational diabetes, and medicines and acute liver injury.