Podcasts about Siegler

Mississippi Today health reporter Allen Siegler and health editor Laura Santhanam give an update on the state's plan to spend its initial pot of opioid lawsuit settlement money. Siegler's in-depth reporting has chronicled some issues and raised serious questions about how the state and local governments are spending the money, which is supposed to help address the scourge of opioid addiction, which has cost at least 10,000 lives in Mississippi since 2000.

M.G. Siegler of Spyglass is back for our monthly tech news discussion. Today we dig into whether Tim Cook will retire in 2026, what his legacy will be, and who will likely succeed him as Apple CEO. We also touch on the various Big Tech companies jostling for the title of largest company in the world and what it says about the AI race. Finally, we cover Anthropic's push to become profitable by 2028 and what it says about the state of the AI race. --- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. Want a discount for Big Technology on Substack + Discord? Here's 25% off for the first year: https://www.bigtechnology.com/subscribe?coupon=0843016b Questions? Feedback? Write to: bigtechnologypodcast@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

If you had millions of people using a product you spent years building, would you kill it?That's exactly what The Browser Company did with Arc.Originally recorded in July before The Browser Company's acquisition by software giant Atlassian earlier this year, we're republishing this episode because its lessons are truly timeless. Today, the team continues to operate independently under Atlassian's umbrella.The internet backlash when the company killed Arc in May 2025 was intense, but cofounders Josh Miller and Hursh Agrawal saw that AI was about to make the web something you talk to, not just click into. The best home for that assistant was the thing that's already between you and the internet—the browser. And they realized they couldn't just duct-tape it on to Arc.One year of heads-down work later, the team launched Dia in beta, and people are raving about it. Dia is a sleek, fast, browser with AI at its core—it gets better with every tab you open, becoming more and more helpful with time. And even though it's still early, Josh and Hursh's big pivot looks like one for the ages.In this episode of AI & I, Josh and Hursh spoke for the first time in a full-length podcast about their pivot from Arc to Dia. We talked through their decision-making process, the very public backlash the company faced, and the grit it took to stay the course. If you found this episode interesting, please like, subscribe, comment, and share! Want even more?Sign up for Every to unlock our ultimate guide to prompting ChatGPT here: https://every.ck.page/ultimate-guide-to-prompting-chatgpt. It's usually only for paying subscribers, but you can get it here for free.To hear more from Dan Shipper:Subscribe to Every: https://every.to/subscribe Follow him on X: https://twitter.com/danshipper Timestamps:00:00:00 - Start00:00:48 - Introduction 00:02:22 - The story of how Dan might've been the CEO of The Browser Company 00:09:40 - The moment Josh and Hursh knew they had to walk away from Arc 00:16:59 - How to handle the weight of the unknown in a pivot 00:23:24 - The prototype-driven culture that kept The Browser Company alive 00:25:06 - Why having a product loved by millions of users isn't enough 00:32:12 - The architectural decisions underlying how Dia was built 00:46:04 - How Dia almost shipped without its best feature 00:50:45 - The best ways people are using Dia in the wild 01:07:27 - How Josh and Hursh think about competing with incumbents 01:17:13 - How romanticism informs the product decisions behind Dia Links to resources mentioned in the episode:Hursh Agrawal: @hurshJosh Miller: @joshmMore about Dia: https://www.diabrowser.com/Writer and investor M.G. Siegler's essay about the AI browser wars: https://spyglass.org/ai-browser-wars/Note: This episode is a rerun from our archives.

You can subscribe on patreon.com/aow40k to listen to part 2

M.G. Siegler of Spyglass is back for our monthly tech news discussion. Today we dig into OpenAI's newly cleared path to an IPO, what trillion-scale capex vs. current revenue implies, and how Microsoft's 27% stake, IP rights, and fresh AWS entanglements complicate the story. We debate whether the market can stomach years of heavy losses, why “AGI or bust” creates systemic risk, and what happens if model gains plateau, compute economics flip, or fast followers erase any AGI edge. Finally, we look at Apple's iPhone 17 resurgence—why it's hitting now and whether it's enough without a breakthrough assistant. Tune in for a clear walkthrough of tech's biggest news with one of the industry's sharpest analysts. --- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. Want a discount for Big Technology on Substack + Discord? Here's 25% off for the first year: https://www.bigtechnology.com/subscribe?coupon=0843016b Questions? Feedback? Write to: bigtechnologypodcast@gmail.com

M.G. Siegler of Spyglass is back for our monthly tech news discussion. Today we discuss OpenAI and AMD's megadeal, whether the AI investment cycle is a disaster waiting to happen, and how NVIDIA might feel about the arrangement. We also discuss Sam Altman and Jony Ive's struggles in developing their own AI device and how all tech companies seem to be building the same AI enabled ambient computing. Finally, we pour one out for the Vision Pro. Tune in for a deep discussion of tech's biggest news with one of the industry's leading analysts. --- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. Want a discount for Big Technology on Substack + Discord? Here's 25% off for the first year: https://www.bigtechnology.com/subscribe?coupon=0843016b Questions? Feedback? Write to: bigtechnologypodcast@gmail.com

En mars 2007, Philippe Vuillet disparaît dans la région de Mulhouse. Après une enquête sommaire, les gendarmes concluent qu'il est parti à Paris refaire sa vie avec une autre femme. Sa compagne Sylvie et ses parents n'y croient pas…Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

M.G. Siegler is the author of Spyglass. He joins Big Technology podcast for the latest of our monthly discussions about Big Tech strategy and AI. Today we cover whether OpenAI broke ChatGPT with its GPT-5 rollout and whether new AI models are similar to typical technology rollouts. We also cover Apple's forthcoming new lineup of phones: the iPhone Air, the folding iPhone, and the curved glass iPhone. We conclude with a discussion of the U.S. taking ownership 10% of Intel. --- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. Want a discount for Big Technology on Substack + Discord? Here's 25% off for the first year: https://www.bigtechnology.com/subscribe?coupon=0843016b Questions? Feedback? Write to: bigtechnologypodcast@gmail.com

Interview with M.G. Siegler. Google improves Gemini AI image editing with 'Nano Banana' model. THIS is why large language models can understand the world. Building a16z's personal AI workstation with four NVIDIA RTX 6000 Pro Blackwell Max-Q GPUs. Elon Musk says xAI has open sourced Grok 2.5. Google says it dropped the energy cost of AI queries by 33x in one year. We must build AI for people; not to be a person. AI 'deadbots' are persuasive — and researchers say they're primed for monetization. AI robots are helping South Korea's seniors feel less alone. College student's "time travel" AI experiment accidentally outputs real 1834 history. Forget Uber Eats—Chipotle's latest delivery option might shock you. There are two types of dishwasher people. Would you go on a tour of your local Amazon warehouse? Perplexity has cooked up a new way to pay publishers for their content. Wired and Business Insider remove articles by AI-generated 'freelancer'. The South Slope Derby. Checking in on the Internet Roadtrip. TikTok. Hosts: Leo Laporte, Jeff Jarvis, and Paris Martineau Guest: M.G. Siegler Download or subscribe to Intelligent Machines at https://twit.tv/shows/intelligent-machines. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free shows, a members-only Discord, and behind-the-scenes access. Join today: https://twit.tv/clubtwit Sponsors: helixsleep.com/twit zscaler.com/security pantheon.io

Schon seid er klein ist, interessiert er sich für Musik und besonders für die Ukulele. Philip Siegler ist zwar erst 10 Jahre alt, aber spielt die Ukulele schon wie ein Profi. Außerdem schreibt er auch schon eigene Lieder. Das Lied Amazonas hat er dem Regenwald in Brasilien gewidmet und hat sich damit beim "Dein Song für EINE WELT" - Contest beworben. Kinderreporter Jakob hat sich mit ihm unterhalten!

M.G. Siegler is the author of Spyglass. He joins Big Technology podcast for the latest of our first Monday of the month discussion about Big Tech strategy and AI. Today we cover Mark Zuckerberg's vision for personal superintelligence and whether it's more of a recruiting play or a real difference in the way the company builds AI. We also cover the massive bets on AI and whether they'll ever pay off, how interlinked big tech is with AI, and whether you should outsource your writing to AI. --- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. Want a discount for Big Technology on Substack + Discord? Here's 25% off for the first year: https://www.bigtechnology.com/subscribe?coupon=0843016b Questions? Feedback? Write to: bigtechnologypodcast@gmail.com

Genießen Sie verschiedene Düfte in Ihrem Garten: Rosmarin, Salbei und Thymian verströmen herbe Noten, während Zitronenverbene erfrischend-zitronig duftet. Zum letzten Mal ist Hubert Siegler bei Edith Schowalter zu Gast. Bevor er sich in den Ruhestand verabschiedet, wird er von seiner Nachfolgerin Isolde Keil-Vierheilig begleitet. Sie beantworten auch Hörerfragen.

Tonight on The Brian Crombie Hour, Brian interviews Jeff Siegler about Urbanism, density, and revitalizing downtowns and suburbs.  Jeff Siegler is an author, speaker, elected official, and consultant concerned with the powerful role place plays in our lives. He is the founder of the civic pride consulting firm, Revitalize, or Die, and co-founder of the organization Proud Places. After obtaining his Master's in Urban Planning from Virginia Commonwealth University, Jeff went to work on Main Street first as a downtown manager, and later as the Ohio Main Street State Coordinator.Jeff Siegel is a municipal commissioner and author of "Your City is Sick". He discusses the impact of the built environment on health, emphasizing how cities have become "sick" due to car-centric urban planning. He highlights how cities have been retrofitted around cars, leading to negative consequences for physical and social health, as well as environmental damage. Jeff suggests that cities need to shift focus from car dependency to creating healthier, more sustainable urban spaces. 

M.G. Siegler is the author of Spyglass. He joins Big Technology podcast for the first installment of our new monthly discussion about Big Tech strategy and AI! Today, we cover why Apple may want to outsource Siri's brain to Anthropic or OpenAI, the rise of voice Ai, why Anthropic could be the right fit, and the complexity of what working with Apple would mean for Anthropic's business. We also touch on Zuck's superintelligence bet, Elon's new third party, the end of the EV credit, and whether AI browsers are worth it. Tune in for the first in our new series! --- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. Want a discount for Big Technology on Substack + Discord? Here's 25% off for the first year: https://www.bigtechnology.com/subscribe?coupon=0843016b Questions? Feedback? Write to: bigtechnologypodcast@gmail.com

If you had millions of people using a product you spent years building, would you kill it?That's exactly what The Browser Company did with Arc.The internet backlash was intense, but cofounders Josh Miller and Hursh Agrawal saw that AI was about to make the web something you talk to, not just click into. The best home for that assistant was the thing that's already between you and the internet—the browser. And they realized they couldn't just duct-tape it on to Arc.One year of heads-down work later, the team launched Dia in beta, and people are raving about it. Dia is a sleek, fast, browser with AI at its core—it gets better with every tab you open, becoming more and more helpful with time. And even though it's still early, Josh and Hursh's big pivot looks like one for the ages.This week on AI & I, Josh and Hursh joined me for their first full-length podcast about their pivot from Arc to Dia. We talk through their decision-making process, the very public backlash the company faced, and the grit it took to stay the course. If you found this episode interesting, please like, subscribe, comment, and share! Want even more?Sign up for Every to unlock our ultimate guide to prompting ChatGPT here: https://every.ck.page/ultimate-guide-to-prompting-chatgpt. It's usually only for paying subscribers, but you can get it here for free.To hear more from Dan Shipper:Subscribe to Every: https://every.to/subscribe Follow him on X: https://twitter.com/danshipper Sponsor: Attio: Go to⁠⁠⁠⁠ https://attio.com/every⁠⁠⁠⁠⁠ and get 15% off your first year on your AI-powered CRM.Timestamps for Spotify:Introduction: 00:01:13The story of how Dan might've been the CEO of The Browser Company: 00:02:47The moment Josh and Hursh knew they had to walk away from Arc: 00:09:42How to handle the weight of the unknown in a pivot: 00:17:08The prototype-driven culture that kept The Browser Company alive: 00:23:31Why having a product loved by millions of users isn't enough :00:25:42The architectural decisions underlying how Dia was built: 00:33:29How Dia almost shipped without its best feature: 00:47:12The best ways people are using Dia in the wild: 00:51:18How Josh and Hursh think about competing with incumbents: 01:07:55How romanticism informs the product decisions behind Dia: 01:17:04Links to resources mentioned in the episode:Hursh Agrawal: @hurshJosh Miller: @joshmMore about Dia: https://www.diabrowser.com/ Writer and investor M.G. Siegler's essay about the AI browser wars: https://spyglass.org/ai-browser-wars/ 

Der Garten ist in der Hochphase: alle Beete sind bestückt, die ersten leeren sich. Fruchtgemüse und Strauchbeeren können gepflückt werden. Der Gartenexperte Hubert Siegler gibt im Ratsch mit Edith Schowalter Tipps zu Pflege- und Kulturarbeiten. Außerdem beantwortet er Hörerfragen.

M.G. Siegler is the author of Spyglass. He joins Big Technology to discuss Apple's subdued WWDC and whether it signals deeper trouble with AI's capabilities. Tune in to hear a breakdown of Apple's “UI over AI” approach, whether the company can pull off the Apple Intelligence vision at all, and if Liquid Glass is a redesign destined to fail. We also cover the vibes at the conference and the state of Apple today. Hit play for clear-eyed, no-nonsense analysis of the tech world's biggest stories. --- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. Want a discount for Big Technology on Substack? Here's 25% off for the first year: https://www.bigtechnology.com/subscribe?coupon=0843016b Questions? Feedback? Write to: bigtechnologypodcast@gmail.com

Die sehr warme Frühlingsphase im April endete mit Ostern und Anfang Mai wurde es recht kalt. Doch nach den Eisheiligen Mitte des Monats können auch kälteempfindliche Pflanzen ins Freie. Weitere Gartentipps hat Hubert Siegler im Ratsch mit Edith Schowalter parat. Er beantwortet auch Hörerfragen.

Show Notes: Are Google and Meta Screwed?And does it make any Sense?April 18, 2025OverviewThis week's newsletter delves into a pivotal moment for two of tech's biggest players: Meta and Google. Long dominant through strategic acquisitions and platform control, both are now under intense legal scrutiny. At the same time, a new platform shift—centered on AI—threatens to upend their business models, just as geopolitical forces reshape global markets.Listeners will gain insight into how antitrust battles, legacy acquisitions, AI innovation, and trade wars intersect to challenge the future of these giants. We'll connect disparate articles to reveal patterns that go beyond individual stories.Key TrendsKey Trend 1: Government Antitrust Pressure and Legal BattlesSignificance: After decades of unchecked growth, Meta and Google face unprecedented antitrust scrutiny. The outcomes could reset the rules for digital markets—and determine whether breakups or massive fines become the norm.Talking Point 1: Meta's High-Stakes Trial“In a just world, the FTC has no shot to win this case. The case is so nebulous and weak…”– M.G. Siegler, “The Meta Points of Meta's Trial” (https://spyglass.org/meta-trial/)• Highlights the FTC's challenge: litigating past acquisitions with vague theories of harm.Talking Point 2: Google Guilty in Ad Tech Monopoly“A judge ruled that Google holds a monopolistic position in the technology of online advertising, unfairly harming rivals and advertisers.”– David McCabe, New York Times(https://www.nytimes.com/2025/04/17/technology/google-ad-tech-antitrust-ruling.html)• Marks the second major U.S. court loss for Google in under a year, setting the stage for structural remedies.Key Trend 2: Strategic Platform Shifts and Legacy AcquisitionsSignificance: Meta's survival has hinged on buying Instagram and WhatsApp; now those very deals are under fire. The pattern echoes past shifts—desktop to mobile—and underscores how acquisitions can both secure and imperil platform relevance.Talking Point 1: The Value and Vulnerability of Instagram“Without Instagram, Meta is screwed.”– M.G. Siegler, Spyglass (https://spyglass.org/without-instagram-meta-is-screwed/)• Shows Instagram's ad revenue underpins Meta's funding for new bets (metaverse, AI).Talking Point 2: Echoes of the Mobile Battle“Facebook 2.0 will try to kill Facebook 1.0 and Google 2.0 will try to kill Google 1.0.”– Editorial, “Are Google and Meta Screwed?” (Newsletter for April 11, 2025)• Reminds us how prior platform shifts demanded reinvention—AI may require the same.Key Trend 3: AI‑Driven Disruption and the Next PlatformsSignificance: Just as mobile upended desktop, AI is redrawing the map of search, discovery, and social engagement. Meta and Google must adapt to challengers like OpenAI, Anthropic, xAI and novel features such as memory and reasoning.Talking Point 1: AI Search and Discovery Race“OpenAI, Anthropic, Perplexity, and Grok capture users for AI based search and discovery.”– Editorial, “Are Google and Meta Screwed?”• Signals user migration away from traditional search and feeds.Talking Point 2: The AI Price War and Memory Features“OpenAI slashes prices for GPT‑4.1 by up to 75%, igniting an AI price war among tech giants.”– Bryson Masse, VentureBeat (https://venturebeat.com/ai/gpt-4-1-ai-price-war-developers/)“Claude's memory feature … allows the chatbot to recall details from previous interactions.”– Michael Nuñez, VentureBeat(https://venturebeat.com/ai/claude-just-gained-superpowers-anthropics-ai-can-now-search-your-entire-google-workspace-without-you/)• Underscores how product feature arms races could outflank legacy ad models.Key Trend 4: Global Economic Realignments and Trade WarsSignificance: Tech doesn't operate in a vacuum. Tariffs and nationalism are reshaping supply chains and consumer behavior, with knock‑on effects for digital giants reliant on ad dollars and global audiences.Talking Point 1: Tariffs as a “Tectonic Plate Shift”“Trump's tariffs are part of a broader movement in the global economy which he describes as a ‘tectonic plate shift.'”– Peter R. Orszag, New York Times video (https://www.nytimes.com/video/opinion/100000010103488/trumps-tariffs-are-part-of-a-tectonic-plate-shift-in-the-global-economy.html)• Reflects how trade policy uncertainty seeps into tech investment and consumer prices.Talking Point 2: The End of Globalism vs Economic Globalization“Globalisation as we've known it for the past couple of decades has come to an end.”– Frank Furedi, Spiked (https://www.spiked-online.com/2025/04/15/the-end-of-globalism-is-nigh/)• Positions economic nationalism alongside persistent interdependence—tech firms must navigate both.Discussion QuestionsHow do the FTC's and DOJ's strategies against Meta and Google reflect a shift in government confidence and capability to regulate tech giants?Would breaking up Instagram and WhatsApp—or forcing Google to divest its ad tech—spur innovation or simply weaken platforms in an era of AI competition?In what ways has the shift from mobile to AI mirrored past platform transitions, and what lessons should Meta and Google apply as they pursue “2.0” strategies?Is the AI price war (GPT‑4.1 cuts, Claude memory, Grok features) a sustainable model for developers and businesses, or will it erode margins across the ecosystem?Do Trump's tariffs and rising economic nationalism ultimately strengthen China's tech incumbents (Huawei, Temu, Shein) more than they pressure U.S. companies? (Controversial)With visionaries like Jack Dorsey and Elon Musk calling to “delete all IP law,” how should tech firms balance creator rights against AI training needs? (Controversial) 7. How does the narrative of “the end of globalism” influence Big Tech's investment in international expansion and localized product strategies?Closing IdeasMeta and Google stand at a crossroads: legal rulings threaten their core business structures while AI challengers redefine user engagement.Their historic playbook—acquiring emerging rivals and evolving ad models—now collides with fast‑moving technology, activist regulators, and geopolitical headwinds.Final Thought: Survival for these giants will depend on agility—embracing AI as the next platform, rethinking past acquisitions, and navigating a world where borders, both digital and national, are being redrawn.Generated on 4/18/2025 with Newsletter Creator This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thatwastheweek.com/subscribe

Die Natur ist mit den warmen Tagen regelrecht "explodiert", auch die Obstblüte hat rasant eingesetzt. Bis Mitte Mai ist jedoch noch mit Nachtfrösten zu rechnen. Welche Schönheiten sich heuer für Balkon und Gemüsebeet anbieten, verrät Hubert Siegler. Der Gartenexperte ist bei Edith Schowalter zu Gast und beantwortet auch Hörerfragen.

Wenn die Tage länger und wärmer werden, juckt's Hobbygärtnern in den Fingern. Der Gartenexperte Hubert Siegler von der Bayerischen Gartenakademie zeigt im Ratsch mit Edith Schowalter, welche Arbeiten schon erledigt werden können und wo noch etwas Geduld gefragt ist.

Mike Siegler joined Matt to discuss keeping yourself safe from digital scams.

M.G. Siegler is a writer and investor and the author of Spyglass. Siegler joins Big Technology for a bonus depisode to discuss DeepSeek R1, the Chinese open-source AI model and its impact on the tech industry. Tune in to hear why DeepSeek's ability to match OpenAI's performance at just 3-5% of the cost could upend the AI industry's economic model. We also cover the immediate market fallout, why Silicon Valley's scaling hypothesis might be invalidated, and what this means for companies like Microsoft, Google, and NVIDIA. Hit play for a timely analysis of one of the most significant developments in AI that could reshape the technology landscape. --- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. For weekly updates on the show, sign up for the pod newsletter on LinkedIn: https://www.linkedin.com/newsletters/6901970121829801984/ Want a discount for Big Technology on Substack? Here's 40% off for the first year: https://tinyurl.com/bigtechnology Questions? Feedback? Write to: bigtechnologypodcast@gmail.com

M.G. Siegler goes way out on a limb with some BIG predictions of things that could happen this year, Simon Willison's year-end roundup is a must-read and perhaps the only thing you have to read to get up-to-speed on the state of the LLM, Allen Pike describes a method for magic, Tom Critchlow thinks small databases are magic & James Stanier agrees with me about Parkinson's Law and the usefulness of deadlines.

M.G. Siegler goes way out on a limb with some BIG predictions of things that could happen this year, Simon Willison's year-end roundup is a must-read and perhaps the only thing you have to read to get up-to-speed on the state of the LLM, Allen Pike describes a method for magic, Tom Critchlow thinks small databases are magic & James Stanier agrees with me about Parkinson's Law and the usefulness of deadlines.

M.G. Siegler goes way out on a limb with some BIG predictions of things that could happen this year, Simon Willison's year-end roundup is a must-read and perhaps the only thing you have to read to get up-to-speed on the state of the LLM, Allen Pike describes a method for magic, Tom Critchlow thinks small databases are magic & James Stanier agrees with me about Parkinson's Law and the usefulness of deadlines.

Writer and Investor M.G. Siegler joins Host and Lightspeed Partner Michael Mignano from London to discuss the European tech scene and his experiences stepping back from venture capital after a decade with GV. The discussion covers the current 'VC Crisis', including CRV Ventures' decision to return funds, and the complex M&A and IPO landscape. Siegler offers his perspective on investing in people vs ideas, the defensibility of startups, and the anticipated evolution towards AGI. Episode Chapters (00:00) Introduction  (00:32) M.G. Siegler's Background and Move to London (01:07) Investing in London vs. San Francisco (03:56) Exploring the London Tech Scene (10:32) Venture Capital's Crisis (13:26) AI and the Future of Startups (18:03) The Role of Acquisitions in Tech (22:15) Challenges and Opportunities in Venture Capital (36:06) Current M&A Environment (39:17) VC Funds and the AI Market (42:01) Scaling AI and Future Breakthroughs (54:00) Is the Consumer Market Dead? (59:39) Apple's Position in the AI Race (01:11:26) Closing Thoughts Stay in touch: www.lsvp.com X: https://twitter.com/lightspeedvp LinkedIn: https://www.linkedin.com/company/lightspeed-venture-partners/ Instagram: https://www.instagram.com/lightspeedventurepartners/ Subscribe on your favorite podcast app: generativenow.co Email: generativenow@lsvp.com The content here does not constitute tax, legal, business or investment advice or an offer to provide such advice, should not be construed as advocating the purchase or sale of any security or investment or a recommendation of any company, and is not an offer, or solicitation of an offer, for the purchase or sale of any security or investment product. For more details please see lsvp.com/legal.

Zum letzten Mal in dieser Gartensaison ist Hubert Siegler von der Bayerischen Gartenakademie bei Edith Schowalter zu Gast. Er gibt Ratschläge für die Wintervorbereitungen und beantwortet Hörerfragen. Außerdem hat er Ausflugstipps für Sie.

Auch im Oktober und November gibt's im Garten einiges zu tun: Sie können Stauden und Obstgehölze pflanzen oder Wintergemüse anbauen. Außerdem wollen die Kübelpflanzen vor der Kälte geschützt werden. Im Gartenratsch mit Tom Viewegh gibt Hubert Siegler Tipps und beantwortet Hörerfragen.

This Week in Startups is brought to you by… Gusto is easy online payroll, benefits, and HR built for modern small businesses. Get three months free when you run your first payroll at https://www.gusto.com/twist Oracle - Oracle Cloud Infrastructure, or OCI, is a single platform for your infrastructure, database, application development, and AI needs. Save up to 50% on your cloud bill at ⁠https://w⁠⁠⁠⁠ww.oracle.com/twist Linear. Linear helps product teams focus on what they do best: Planning and building great products. Streamline issues, projects, and product roadmaps in a tool your team will actually enjoy using. Get 25% off at https://www.linear.app/twist * Todays show: M.G. Siegler joins Jason and Alex to discuss the current venture capital crisis (14:11), and challenges in the venture industry, particularly in early-stage returns and high valuations (18:42). They also address future exits and the impact of regulatory measures on M&A (27:14), Google's antitrust case (49:08), and much more! * Timestamps: (0:00) M.G. Siegler joins Jason and Alex (5:05) M.G. Siegler's journey from journalism to venture capital (8:33) Differences between journalism and venture capital (10:02) Gusto - Get three months free when you run your first payroll at https://gusto.com/twist (11:02) Media training and transparency in companies (14:11) Venture capital's current state and CRV's capital return (16:23) Challenges and opportunities in the venture industry (18:42) Early stage venture returns and the impact of high valuations (21:42) Oracle - Try OCI and save up to 50% on your cloud bill at at https://w⁠⁠⁠⁠ww.oracle.com/twist (23:07) Future exits and liquidity evaluations in startups (27:14) Acquisitions, hackquisitions, and regulatory impact on M&A (34:09) Venture capital dynamics and fundraising during market downturn (35:48) Predictions for the startup market recovery (38:02) Linear - Streamline issues, projects, and product roadmaps in a tool your team will actually enjoy using. Get 25% off at https://www.linear.app/twist (38:57) AI competition among tech giants and Meta's hardware challenges (45:47) Venture capital dynamics and favorite AI tools (49:08) Google's antitrust case (55:25) Possible effects of opening Google's search API (1:03:41) Potential Google spin-offs (1:06:27) Audience Q&A * Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com * Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Mentioned on the show: https://www.cnbc.com/2024/10/08/doj-indicates-its-considering-google-breakup-following-monopoly-ruling.html https://spyglass.org/vc-crisis * Follow M.G. Siegler: X: https://x.com/mgsiegler LinkedIn: https://www.linkedin.com/in/mgsiegler/?originalSubdomain=uk Check out: https://www.spyglass.org * Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm * Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Thank you to our partners: (10:02) Gusto - Get three months free when you run your first payroll at https://gusto.com/twist (21:42) Oracle - Try OCI and save up to 50% on your cloud bill at at https://w⁠⁠⁠⁠ww.oracle.com/twist (38:02) Linear - Streamline issues, projects, and product roadmaps in a tool your team will actually enjoy using. Get 25% off at https://www.linear.app/twist * Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland * Check out Jason's suite of newsletters: https://substack.com/@calacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Der Herbst ist da, das bedeutet die Böden sind feuchter und weniger Wasser verdunstet. Das Gartenjahr neigt sich dem Ende zu. Jetzt stehen Ernte und Pflege an. Im Ratsch mit Edith Schowalter gibt Hubert Siegler von der Bayerischen Gartenakademie Tipps und beantwortet Hörerfragen.

Das warme und feuchte Augustwetter begünstigt Pilzerkrankungen an Pflanzen. Im Gartenratsch mit Edith Schowalter gibt Hubert Siegler von der Bayerischen Gartenakademie Tipps, wie Sie Mehltau und Krautfäule in Schach halten und beantwortet Hörerfragen. Begleitet wird er von der Gartenbautechnikerin aus Veitshöchheim, Isolde Keil-Vierheilig.

Remarks about a model clinician. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Das schwül-feuchte Sommerwetter begünstigt Fäulnis und Krankheiten bei Nutzpflanzen. Hubert Siegler von der Bayerischen Gartenakademie gibt im Ratsch mit Edith Schowalter Tipps, wie Sie Abhilfe schaffen können. Er beantwortet auch Hörerfragen.

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: September 20, 2018 Apomorphine has a more than 20-year history as a therapeutic adjunct in the management of idiopathic Parkinson disease. And yet, no randomized, placebo-controlled clinical trial to show for it. As of July 2018, now there is. In this week's episode of BrainWaves, Dr. Siegler discusses the relevance, strengths, and weaknesses of the TOLEDO trial. Produced by James E. Siegler. Music by Ondrosik and Rod Hamilton. Sound effects by Mike Koenig, Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCESKatzenschlager R, Poewe W, Rascol O, et al. Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial. Lancet Neurol 2018;17(9):749-59. PMID 30055903 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

Der Starkregen mit Überschwemmungen hat auch in vielen Gärten Schäden angerichtet. Doch Hubert Siegler von der Bayerischen Gartenakademie hat auch gute Nachrichten: Den Erdbeeren hat das Wasser gutgetan. Im Ratsch mit Edith Schowalter gibt er Tipps und beantwortet Hörerfragen.

Apple gaat volgens de EU niet ver genoeg met het gelijkmaken van het app-speelveld op zijn apparaten. Apple loopt daarom risico op een mega-boete. En door dezelfde wet durft Apple zijn nieuwe AI-functies straks niet meteen in de EU uit te brengen, of is er meer aan de hand?Naast de bijna-vete tussen Apple en de Europese Commissie bespreken we in deze aflevering van de Bright Podcast ook: weer een Nederlandse thuisbatterij, opvallende samenwerking tussen Volkswagen en Rivian en het volgende Google Pixel-evenementkomt veel vroeger dan verwacht.In deze aflevering refereren we aan dit artikel van M.G. Siegler en dit artikel met citaten van Eurocommissaris Margrethe Vestager (Medediging) van NU.nl. Sponsor:Krijg 60 procent korting op een abonnement op Incogni, een dienst die je online-privacy verbetert. Incogni laat jouw gegevens verwijderen bij datahandelaren. Ga naar: incogni.com/brightTips uit deze aflevering:App: Gentler Streak, een veelzijdige maar vooral heel vriendelijke fitnesscracker voor je iPhone en Apple Watch. Je kan pauze-dagen nemen zonder je 'streak' te verbreken en die streak is ook wat vriendelijker. De app pusht je niet om steeds het uiterste te geven, maar probeert juist met de zachte hand een stijgende lijn aan te houden. Want je kan beter langer doen over een gestage stijging, dan jezelf een blessure bezorgen met te grote ambities.App: Binge, voor streaming lovers, van de makers van TVGids.nl. Je kan aanvinken welke streaming-apps je gebruikt, en krijgt dan kijktips. Ook kun je bijhouden wat je kijkt, zodat je ziet of er nieuwe seizoenen zijn. En je kan goed zien welke films en series op dit moment in Nederland beschikbaar zijn, en op welke dienst. Daar waren al wel andere opties voor, maar niet eerder specifiek gericht op de Nederlandse kijker. Gratis te downloaden voor Android en iOS.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.

M.G. Siegler of Spyglass is back to recap Apple's big AI-themed WWDC event and look ahead to AI's broader potential moving forward. Tune for an in-depth analysis of Apple's new AI features, and what they say about the strengths and limitations of the current AI models. We cover whether the new features will lead to an iPhone upgrade cycle, the stock market's reaction, Elon Musk getting angry about the event, why OpenAI played a smaller role than many anticipated, Apple's potential robotics future, and where Apple stands after the big reveal. Hit play for a timely conversation that goes beyond the hype to examine the real-world implications of Apple's foray into AI. --- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. For weekly updates on the show, sign up for the pod newsletter on LinkedIn: https://www.linkedin.com/newsletters/6901970121829801984/ Want a discount for Big Technology on Substack? Here's 40% off for the first year: https://tinyurl.com/bigtechnology Questions? Feedback? Write to: bigtechnologypodcast@gmail.com

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021.Originally released: December 26, 20192019 was a big year. The year of the Mueller report. The American college admissions scandals. Brexit. But it was also the year the US Women's team won the World Cup and lobbied for the equal pay of women and men in sports. It was the year of NMO, in which several pivotal trials showed the benefit of disease-modulating therapy in this condition. The year Will Smith played Genie in Aladdin.2019 was a great year. And as we wrap up 2019, this week's episode includes some of the highlights. Enjoy!Produced by James E Siegler with support from Erika Mejia, Rajat Dhar, and the entire Siegler family. Music courtesy of Axletree, Chris Zabriskie, John Paston, Kevin Mcleod, Josh Woodward, Steve Combs, Lee Rosevere, Scott Holmes, Advent Chamber Orchestra, Coldnoise, and Pachyderm. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast.REFERENCES[BRAIN FOOD]Devore EE, Kang JH, Breteler MM, Grodstein F. Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol 2012;72(1):135-43. PMID 22535616Kennedy DO, Wightman EL, Reay JL, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 2010;91(6):1590-7. PMID 20357044Lefèvre-Arbogast S, Gaudout D, Bensalem J, et al. Pattern of polyphenol intake and the long-term risk of dementia in older persons. Neurology 2018;90(22):e1979-e1988. PMID 29703769Liu QP, Wu YF, Cheng HY, et al. Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and meta-analysis of prospective cohort studies. Nutrition 2016;32(6):628-36. PMID 26944757Miller MG, Hamilton DA, Joseph JA, Shukitt-Hale B. Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. Eur J Nutr 2018;57(3):1169-80. PMID 28283823Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement 2015;11(9):1015-22. PMID 26086182Newman JC, Covarrubias AJ, Zhao M, et al. Ketogenic diet reduces midlife mortality and improves memory in aging mice. Cell Metab 2017;26(3):547-57.e8. PMID 28877458Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol 2014;13(8):788-94. Erratum in: Lancet Neurol 2014;13(11):1070. PMID 25030513Okkersen K, Jimenez-Moreno C, Wenninger S, et al. Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial. Lancet Neurol 2018;17(8):671-80. PMID 29934199Radd-Vagenas S, Duffy SL, Naismith SL,

Special guest M.G. Siegler returns to the show to talk about the new iPad Pros, the iPadOS/MacOS functional gulf, the OpenAI/Scarlett Johansson controversy, and M.G.'s new blog Spyglass.

Anfang April war es sehr warm, was für einen Wachstumsvorsprung im Garten sorgte. Mit dem Kälteeinbruch wurde der eingebüßt und viele Blüten und junge Triebe beschädigt. Im Gartenratsch auf BR Heimat gibt Experte Hubert Siegler Tipps, wie es jetzt im Mai weitergeht. Er beantwortet auch Hörerfragen.

In this podcast episode, John Golden from Sales POP Online Sales Magazine and Pipeline CRM interviews Blair Siegler, CEO and founder of Quantico. They discuss the role of negotiation intelligence in B2B sales, focusing on how discounts and concessions affect profitability. Blair shares insights from his time at Meta, emphasizing the importance of a value exchange in negotiations.

M.G. Siegler is a venture partner at GV, formerly google ventures, and the author of Spyglass. He joins Big Technology Podcast to discuss what Apple may have cooking for its AI-themed WWDC event in June. We discuss what Apple may do on the consumer front, including how much of iOS it's willing to change in service of AI features. And then we dig into its potential AI play for developers, including on-device processing and its own foundational model. We also talk about its interest in robotics. Tune in for a deep dive into Apple's AI options as it gears up for big announcements in the coming months. ---- Enjoying Big Technology Podcast? Please rate us five stars ⭐⭐⭐⭐⭐ in your podcast app of choice. For weekly updates on the show, sign up for the pod newsletter on LinkedIn: https://www.linkedin.com/newsletters/6901970121829801984/ Want a discount for Big Technology Premium? Here's 40% off for the first year: https://tinyurl.com/bigtechnology Questions? Feedback? Write to: bigtechnologypodcast@gmail.com

Der Frühling ist ungewöhnlich warm, was nach einem meist milden Winter zu einem "Frühstart" in die Gartensaison geführt hat. Im Ratsch mit Edith Schowalter zeigt der Gartenexperte Hubert Siegler, warum Sie manche Blüten trotzdem nachts noch schützen sollten. Außerdem beantwortet er Hörerfragen.

Welcome back to the Neurophilia Podcast! In today's episode, we are joined by the podcast legend himself, Dr. Jim Siegler to discuss vascular neurology.  The field of vascular neurology has had incredible advancements within the past few decades through thrombolytics/mechanical thrombectomy and has seen increased public awareness and accessibility to stroke care. As a result of this, vascular neurology training is consistently among the top fellowships pursued by graduating residents.  Listen to this episode to hear more about the subspecialty of vascular neurology!Dr. Jim Siegler: After obtaining his bachelor's degrees in Neuroscience and History of Science, Medicine, and Technology at Johns Hopkins University, Dr. Jim Siegler completed his medical education at Tulane University School of Medicine in New Orleans. He then completed his adult neurology residency and vascular neurology fellowship at UPenn. He currently serves as the Inpatient Medical Director and Director of the Comprehensive Stroke Center at the University of Chicago. Dr. Siegler's research interests include atherosclerotic disease, perfusion imaging, and eligibility of neurointervention for acute intracranial occlusion for which he has published more than 200 peer-reviewed publications. Dr. Siegler is also a passionate medical educator; he is well-known for previously producing an independent podcast titled BrainWaves  a well as the official podcasts for the Neurocritical Care Society, American Academy of Neurology, American Neurological Association podcast ANA Investigates, but more recently he serves on the e-learning subcommittee of the AAN and helps produce their NeuroBytes, and he serves on the digital strategy team for journal Stroke: Vascular and Interventional Neurology where you might have heard his voice on their podcast, ACCESS. Follow Dr.  Jim Siegler on Twitter @JimSieglerFollow Dr.  Nupur Goel on Twitter @mdgoelsFollow Dr.  Blake Buletko on Twitter @blakebuletkoFollow the Neurophilia Podcast on Twitter and Instagram @NeurophiliaPodSupport the show

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Nach einem recht milden und nassen Winter geht's jetzt wieder in die Gartensaison. Im Ratsch mit Edith Schowalter zeigt Hubert Siegler von der Landesanstalt für Gartenbau, welche Arbeiten nun zu erledigen sind und womit Sie lieber noch ein bisschen warten sollten. Er beantwortet auch Hörerfragen.

En mars 2007, Philippe Vuillet disparaît dans la région de Mulhouse. Après une enquête sommaire, les gendarmes concluent qu'il est parti à Paris refaire sa vie avec une autre femme. Sa compagne Sylvie et ses parents n'y croient pas…

Kelly Siegler, former Texas bureau chief of special crimes unit & prosecutor, joined the show this morning. Siegler has a new true-crime series, "Prosecuting Evil," which examines the most harrowing homicides and toughest trials in Texas history. See omnystudio.com/listener for privacy information.

Jeff Siegler is back with an incredibly thought-provoking episode about built places, communities, assumptions, and loneliness, and why designing our spaces and cities and towns to promote community is so important. This episode has it all: hot takes, hard truths, hard-to-discuss-but-mega-important ideas, and solutions to forge a better path forward.    (Please tell us you also read that last sentence like Bill Hader's SNL character Stefon on Weekend Update.)    About Jeff:   Jeff Siegler is a writer, speaker, and consultant concerned with the powerful role place plays in our lives. He is the founder of the civic pride consulting firm, Revitalize, or Die and co-founder of the organization Proud Places. After obtaining his Masters in Urban Planning from Virginia Commonwealth University, Jeff went to work on Main Street. First as a downtown manager, and later as the Ohio Main Street State Coordinator. His first book, “Your City is Sick" is scheduled to be released on September 1st.. Jeff and his wife Amber and their four kids call Pittsburgh home.     In this episode, we cover: Why we need to be intentional about our communities Why beauty actually isn't all that subjective How the “urban” and “rural” labels can contribute to divisiveness and blind spots How much our built environment affects our health A better way forward Links and Resources Mentioned: Your City is Sick Website (almost ready! Keep checking back!) YourCityisSick.com Ann Sussman's Cognitive Architecture  Ep. 99 with Jeff - How to Combat Apathy in Your Small Town: https://www.growingsmalltowns.org/post/episode99