Podcasts about Erratum

Episode 188: RSV Management and PreventionDr. Sandhu and future Dr. Mohamed summarize the management of RSV and describe how to prevent it with chemoprophylaxis and vaccines. Dr Arreaza adds some comments about RSV vaccines.Written by Abdolhakim Mohamed, MSIV, Ross University School of Medicine. Comments by Ranbir Sandhu, MD, and Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.What is RSV? -The Respiratory syncytial Virus (RSV) is an enveloped, negative-sense, single-stranded RNA virus of the Orthopneumovirus genus within the Pneumoviridae family. -RSV is a major cause of acute respiratory tract infections, particularly bronchiolitis and pneumonia, in infants and young children, and it also significantly affects older adults and immunocompromised individuals. -RSV infections cause an estimated 58,000–80,000 hospitalizations among children younger than 5 years and 60,000–160,000 hospitalizations among adults older than 65 years each year.-RSV is highly contagious and spreads through respiratory droplets and direct contact with contaminated surfaces. The virus typically causes seasonal epidemics, peaking in the winter months in temperate climates and during the rainy season in tropical regions. -Virtually all children are infected with RSV by the age of two, and reinfections can occur throughout life, often with milder symptoms.-Per the 2014 Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis, from the American Academy of Pediatrics, the most common etiology of bronchiolitis is RSV. -About 97% of children are infected with RSV in the first 2 years of life, about 40% will experience lower respiratory tract infection during the initial infection. Other viruses that cause bronchiolitis include human rhinovirus, human metapneumovirus, influenza, adenovirus, coronavirus, and parainfluenza viruses.When is RSV season?-Classically, the highest incidence of infection occurs between December and March in North America. Per CDC, there were typical prepandemic RSV season patterns, but the COVID-19 pandemic disrupted RSV seasonality during 2020–2022. -Before we dive into the seasonality patterns, for context, in order to describe RSV seasonality in the US, data was gathered and analyzed from polymerase chain reaction (PCR) test results reported to the National Respiratory and Enteric Virus Surveillance System (NREVSS) during July 2017–February 2023. -Seasonal RSV epidemics were defined as the weeks during which the percentage of PCR test results that were positive for RSV was ≥3%. Per 2017–2020 data, RSV epidemics in the United States typically follow seasonal patterns, that began in October, peaked in December or January, and ended in April. -However, during 2020–21, the typical winter RSV epidemic did not occur. The 2021–22 season began in May, peaked in July, and ended in January. -The 2022–23 season started (June) and peaked (November) later than the 2021–22 season, but earlier than prepandemic seasons. CDC notes that the timing of the 2022–23 season suggests that seasonal patterns are returning toward those observed in prepandemic years, however, warn that clinicians should be aware that off-season RSV circulation might continue.Treatment of RSVSome key points of the 2014 pediatric guidelines from the American Academy of Pediatrics.-AAP strongly do not recommend beta agonists or steroids for viral associated bronchiolitis because of no significant improved outcomes. “Clinicians should not administer albuterol (or salbutamol) to infants and children with a diagnosis of bronchiolitis (Evidence Quality: B; Recommendation Strength: Strong Recommendation).”-Epinephrine is not recommended for infants and children with a diagnosis of bronchiolitis (Evidence Quality: B; Recommendation Strength: Strong Recommendation).-Nebulized hypertonic saline should not be administered to infants with a diagnosis of bronchiolitis in the emergency department (Evidence Quality: B; Recommendation Strength: Moderate Recommendation), but hypertonic saline may be administered when they are hospitalized (Evidence Quality: B; Recommendation Strength: Weak Recommendation [based on randomized controlled trials with inconsistent findings]).-Chest physiotherapy should not be used in infants and children with a diagnosis of bronchiolitis (Evidence Quality: B; Recommendation Strength: Moderate Recommendation).-Antibiotics should not be administered in bronchiolitis unless there is a concomitant bacterial infection, or a strong suspicion of one (Evidence Quality: B; Recommendation Strength: Strong Recommendation).-Oxygen therapy may not be administered if the oxyhemoglobin saturation exceeds 90% in infants and children with a diagnosis of bronchiolitis (Evidence Quality: D; Recommendation Strength: Weak Recommendation [based on low level evidence and reasoning from first principles]).-Clinicians should administer nasogastric or intravenous fluids for infants with a diagnosis of bronchiolitis who cannot maintain hydration orally (Evidence Quality: X; Recommendation Strength: Strong Recommendation).How do we prevent RSV?Infant Immuno-prophylaxis:A clinical trial in 2022 demonstrated that a single injection of nirsevimab (Beyfortus®), administered before the RSV season, protected healthy late-preterm and term infants from RSV-associated lower respiratory tract that required medical treatment. Nirsevimab is a monoclonal antibody to the RSV fusion protein that has an extended half-life.Additionally, on August 3, 2023, the Advisory Committee on Immunization Practices (ACIP) recommended nirsevimab for all infants younger than 8 months who are born during or entering their first RSV season and for infants and children between 8-19 months who are at increased risk for severe RSV disease and are entering their second RSV season. On the basis of pre-COVID-19 pandemic patterns, nirsevimab could be administered in most of the continental United States from October through the end of March.Maternal Vaccination: The CDC recommends the administration of the RSVPreF vaccine to pregnant women between 32 0/7 and 36 6/7 weeks of gestation. This vaccination aims to reduce the risk of RSV-associated lower respiratory tract infection in infants during the first 6 months of life.At this time, if a pregnant woman has already received a maternal RSV vaccine during any previous pregnancy, CDC does not recommend another dose of RSV vaccine during subsequent pregnancies.Older individuals: -Each year in the U.S., it is estimated that between 60,000 and 160,000 older adults are hospitalized and between 6,000 and 10,000 die due to RSV infection-ABRYSVO's approval will help offer older adults protection in the RSV season.-On June 26, 2024, ACIP voted to give these recommendations: all adults older than 75 years and adults between 60–74 years who are at increased risk for severe RSV disease should receive a single dose of RSV vaccine (Abrysvo®).Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Hamid S, Winn A, Parikh R, et al. Seasonality of Respiratory Syncytial Virus — United States, 2017–2023. MMWR Morb Mortal Wkly Rep 2023;72:355–361. DOI: http://dx.doi.org/10.15585/mmwr.mm7214a1Hammitt LL, Dagan R, Yuan Y, Baca Cots M, Bosheva M, Madhi SA, Muller WJ, Zar HJ, Brooks D, Grenham A, Wählby Hamrén U, Mankad VS, Ren P, Takas T, Abram ME, Leach A, Griffin MP, Villafana T; MELODY Study Group. Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants. N Engl J Med. 2022 Mar 3;386(9):837-846. doi: 10.1056/NEJMoa2110275. PMID: 35235726.Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, Johnson DW, Light MJ, Maraqa NF, Mendonca EA, Phelan KJ, Zorc JJ, Stanko-Lopp D, Brown MA, Nathanson I, Rosenblum E, Sayles S 3rd, Hernandez-Cancio S; American Academy of Pediatrics. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014 Nov;134(5):e1474-502. doi: 10.1542/peds.2014-2742. Erratum in: Pediatrics. 2015 Oct;136(4):782. doi: 10.1542/peds.2015-2862. PMID: 25349312.CDC, per their published article Seasonality of Respiratory Syncytial Virus — United States for 2017–2023, in the United StatesWhat U.S. Obstetricians Need to Know About Respiratory Syncytial Virus.Debessai H, Jones JM, Meaney-Delman D, Rasmussen SA. Obstetrics and Gynecology. 2024;143(3):e54-e62. doi:10.1097/AOG.0000000000005492.Maternal Respiratory Syncytial Virus Vaccination and Receipt of Respiratory Syncytial Virus Antibody (Nirsevimab) by Infants Aged

Raphael Coelho e Ênio Macedo convidam Guilherme Kenzo para falar sobre abordagem de suicídio no PS em três casos.Precisa de ajuda? Ligue 188 - Centro de valorização da vida.Referências:1. Stene-Larsen, Kim, and Anne Reneflot. “Contact with primary and mental health care prior to suicide: A systematic review of the literature from 2000 to 2017.” Scandinavian journal of public health vol. 47,1 (2019): 9-17. doi:10.1177/14034948177462742. Walby, Fredrik A et al. “Contact With Mental Health Services Prior to Suicide: A Systematic Review and Meta-Analysis.” Psychiatric services (Washington, D.C.) vol. 69,7 (2018): 751-759. doi:10.1176/appi.ps.2017004753. Sher, L. “Preventing suicide.” QJM : monthly journal of the Association of Physicians vol. 97,10 (2004): 677-80. doi:10.1093/qjmed/hch1064. Domaradzki, Jan. “The Werther Effect, the Papageno Effect or No Effect? A Literature Review.” International journal of environmental research and public health vol. 18,5 2396. 1 Mar. 2021, doi:10.3390/ijerph180523965. https://www.planalto.gov.br/ccivil_03/leis/leis_2001/l10216.htm#:~:text=LEI%20No%2010.216%2C%20DE,modelo%20assistencial%20em%20sa%C3%BAde%20mental6. https://mpce.mp.br/wp-content/uploads/2018/04/20180061-OMS-Prevencao-do-Suicidio-Manual-para-profissionais-da-midia.pdf7. Niederkrotenthaler, Thomas et al. “Role of media reports in completed and prevented suicide: Werther v. Papageno effects.” The British journal of psychiatry : the journal of mental science vol. 197,3 (2010): 234-43. doi:10.1192/bjp.bp.109.0746338. Phillips, D P. “The influence of suggestion on suicide: substantive and theoretical implications of the Werther effect.” American sociological review vol. 39,3 (1974): 340-54.9. Jack, Belinda. “Goethe's Werther and its effects.” The lancet. Psychiatry vol. 1,1 (2014): 18-9. doi:10.1016/S2215-0366(14)70229-910. Jack, Belinda. “Goethe's Werther and its effects.” The lancet. Psychiatry vol. 1,1 (2014): 18-9. doi:10.1016/S2215-0366(14)70229-911. Guinovart, Martí et al. “Towards the Influence of Media on Suicidality: A Systematic Review of Netflix's 'Thirteen Reasons Why'.” International journal of environmental research and public health vol. 20,7 5270. 27 Mar. 2023, doi:10.3390/ijerph2007527012. Cipriani, Andrea et al. “Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis.” BMJ (Clinical research ed.) vol. 346 f3646. 27 Jun. 2013, doi:10.1136/bmj.f364613. BOTEGA, Neury Jose. Crise Suicida: Avaliação e manejo. Porto Alegre: Artmed, 2015.14. Seena Fazel, Bo Runeson. Suicide. N Engl J Med 2020;382:266-274. DOI: 10.1056/NEJMra190294415. Gustavo Turecki et al. Suicide and suicide risk. Nat Rev Dis Primers. 2019. Oct 24;5(1):74. doi: 10.1038/s41572-019-0121-0.16. https://www.setembroamarelo.com/17. Cartilha de prevenção de suicídio: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/cartilhas/2024/cartilha-prevencao-de-suicidios.pdf/view18. Baldaçara L, Rocha GA, Leite VDS, Porto DM, Grudtner RR, Diaz AP, Meleiro A, Correa H, Tung TC, Quevedo J, da Silva AG. Brazilian Psychiatric Association guidelines for the management of suicidal behavior. Part 1. Risk factors, protective factors, and assessment. Braz J Psychiatry. 2021 Sep-Oct;43(5):525-537. doi: 10.1590/1516-4446-2020-0994. PMID: 33111773; PMCID: PMC8555650. - https://pubmed.ncbi.nlm.nih.gov/33111773/19. Baldaçara L, Grudtner RR, da S Leite V, Porto DM, Robis KP, Fidalgo TM, Rocha GA, Diaz AP, Meleiro A, Correa H, Tung TC, Malloy-Diniz L, Quevedo J, da Silva AG. Brazilian Psychiatric Association guidelines for the management of suicidal behavior. Part 2. Screening, intervention, and prevention. Braz J Psychiatry. 2021 Sep-Oct;43(5):538-549. doi: 10.1590/1516-4446-2020-1108. Erratum in: Braz J Psychiatry. 2021 Sep-Oct;43(5):563. doi: 10.1590/1516-4446-2020-0025. PMID: 33331533; PMCID: PMC8555636. - https://pubmed.ncbi.nlm.nih.gov/33331533/20. https://cvv.org.br/wp-content/uploads/2023/08/manual_prevencao_suicidio_profissionais_saude.pdf21. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/boletins/epidemiologicos/edicoes/2024/boletim-epidemiologico-volume-55-no-04.pdf

The Empowered Eating Pep Talk

Yeah, yeah. It's April Fool's Day today...technically. And yes, we've pulled our japes in the past. You're right to be on your guard. But we promise, this is just a normal episode. Ok, maybe not normal normal. It's a pretty great episode, actually! Joining Lizzy and Nate in Spielenwald's basement studio are frequent guests, Z and Rich Johnson. They've come to talk about, spoil, examine, dissect, illuminate, and swear copiously about The Martian, Andy Weir's 2011 novel and Ridley Scott's 2015 adaptation of the same name. Both versions are pretty well out of sight, and there's a lot about both to dig. Even still, when we do run into the occasional speed bump you can be certain we'll talk our way through whatever it is. We're here for the vibes. Ayyy! Erratum: as far can be determined, Andy Weir does nor or has not lived in the PNW. We'll not hold it against him. Several good people don't.

Big changes are here! In this episode, we dive deep into the latest erratums shaking up Altered TCG. From surprising nerfs to unexpected buffs, we break down what's new, what it means for the meta, and how these updates will impact your decks going forward. Whether you're a competitive player or a casual fan, you won't want to miss this breakdown of the game's newest twists!Help Support ARCHONS CORNER► DONATIONS ARE ALWAYS APPRECIATED https://bit.ly/2HGzjxs► GET YOUR MERCH https://bit.ly/3NCScme Follow ARCHONS CORNER on Social Media► BECOME A PATRON https://bit.ly/2HHG8ik► TWITTER https://bit.ly/4hjoq3A ► FACEBOOK https://bit.ly/3UgCP6w ► INSTAGRAM https://bit.ly/48yZrW1 ► TIKTOK https://bit.ly/48jQrE3 ► JOIN US ON DISCORD https://discord.gg/eksCQTmFollow ALTERED CORNER on Social Media► Twitter https://bit.ly/AlteredCx►Twitch https://bit.ly/3NxEQYh► Instagram https://bit.ly/AltCInsta► Discord https://bit.ly/3YuuAq2FIND US ON THESE GREAT PODCASTING PLATFORMSArchons Corner #keyforgeAltered Corner #Alteredtcg ►Podbean: https://bit.ly/2VjDu5U► Apple: https://apple.co/2vONM3I► Stitcher: https://bit.ly/2LQTU6v► Spreaker: https://bit.ly/2PYCCT1► TuneIn: https://bit.ly/2VkcRhg► Spotify: https://spoti.fi/2VhHqnJ► Google Play: https://bit.ly/2VxjSA5

Een speciale bonusaflevering in de vorm van een erratum op Voetnoten 24 waarin verwarring ontstond over het begrip koolstofverwijdering. Laetitia Ouillet legt uit wat het begrip koolstofverwijdering inhoudt en waar het misverstand vandaan kwam. See omnystudio.com/listener for privacy information.

Ivermectin, widely known as an antiparasitic medication, has been investigated for its potential anticancer properties in preclinical studies. Researchers have explored its effects on various cancer cell lines and its possible mechanisms of action. In this episode, Dr. Moss weighs in on this controversial topic, and let's us know where he feels the scientific research stands, and what the implications of the research mean for the future of cancer treatment.

Parfois appelé Morue, d'autres fois appelé Cabillaud, ce poisson change de nom en fonction de la manière dont on le consomme. Les plus jeunes n'apprécient pas forcément son huile de foie pourtant réputée pour la croissance et le développement du cerveau. La Morue, longtemps considérée comme un poisson populaire, est désormais un mets apprécié aux tables de grands restaurants !ERRATUM : "stockfisch", terme employé en français pour la morue séchée, vient au départ du néerlandais "stockvis" (avec "stock" signifiant effectivement "bâton" et "vis"/"fisch" "poisson"), et est orthographié dans notre langue à l'allemande et non à l'anglaise. D'ailleurs, afin de désigner un bâton, les Britanniques utilisent le mot "stick" et non "stock" (deux noms ayant cela dit une origine commune, l'anglais, l'allemand et le néerlandais étant des langues germaniques). Retrouve l'article de Bérénice Toutant sur le site de Baleine sous Gravillon_______

1993 a été une grande année pour le hip-hop, la seconde année d'une période de cinq ans, sans doute la plus forte de l'histoire du hip-hop (1992-1996), une période qui nous a donné des sorties monumentales de plusieurs groupes et rappeurs solo ! C'est aussi une année qui voit le rap à mi-chemin entre l'indie et le mainstream pas encore tout à fait là. Erratum: contrairement à ce qui est dit dans l'épisode, Busta Rhymes a bien grandi à East Flatbush, BROOKLYN, et non de Jamaica Queens :p

Eileen Egan, DNP, FNP-C, BC-ADM, CDCES, FADCES joins The Huddle to share her expertise about the interplay between weight and glycemic management in people with Type 2 diabetes, the importance of meeting glycemic and weight goals early after a Type 2 diabetes diagnosis, as well as best practices for helping people stay motivated and engaged. This episode was made possible with support from Lilly, A Medicine Company. Learn more about this topic in this accompanying patient/client handout (support for the development of this handout was provided by Lilly, A Medicine Company): adces_tipsheet_early_control2.pdf References:American Diabetes Association. Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of care in diabetes- 2024. Diabetes Care, 47(1): S145-S157.Center for Disease Control and Prevention. Adult overweight and obesity. https://www.cdc.gov/obesity/basics/adult-defining.htmlDCCT/EDIC study research group. Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes: The DCCT/EDIC Study 30-Year Follow-up. Diabetes Care. 2016;39(5):686-693. Gregg E, Jakicic J, Blackburn G, et al. Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post hoc analysis of the Look AHEAD randomized clinical trial. Lancet Diabetes Endocrinol. 2016; 4(11): 913-921.Gutiérrez-Cuevas J, Santos A, Armendariz-Borunda J. Pathophysiological Molecular Mechanisms of Obesity: A Link between MAFLD and NASH with Cardiovascular Diseases. Int J Mol Sci. 2021. 27;22(21):11629.Howard BV, Ruotolo G, Robbins DC. Obesity and dyslipidemia. Endocrinol Metab Clin North Am. 2003;32(4):855-867. Jin X, et al. Pathophysiology of obesity and its associated diseases. Acta Pharm Sin B. 2023;13(6):2403-2424.  Laiteerapong N, Ham SA, Gao Y, et al. The legacy effect in type 2 diabetes: impact of early glycemic control on future complications (The Diabetes & Aging Study). Diabetes Care. 2019;42(3):416-426.Lean MEJ, Leslie WS, Barnes AC, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial.Lancet Diabetes Endocrinol. 2019;7(5):344-355.Lingvay I, Sumithran P, Cohen RV, le Roux CW. Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation. Lancet. 2022 Jan 22;399(10322):394-405. doi: 10.1016/S0140-6736(21)01919-X. Epub 2021 Sep 30. Erratum in: Lancet. 2022 Jan 22;399(10322):358. PMID: 34600604Rachel G. Miller, Trevor J. Orchard; Understanding Metabolic Memory: A Tale of Two Studies. Diabetes 1 March 2020; 69 (3): 291–299. https://doi.org/10.2337/db19-0514Ross, R., Neeland, I.J., Yamashita, S. et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol16, 177–189 (2020). https://doi.org/10.1038/s41574-019-0310-7Thom G, McIntosh A, Messow CM, et al. Weight loss-induced increase in fasting ghrelin concentration is a predictor of weight regain: Evidence from the Diabetes Remission Clinical Trial (DiRECT). Diabetes Obes Metab. 2021;(23):711-719.Tsai AG, Bessesen DH. Obesity. Ann Intern Med. 2019;170(5):ITC33-ITC48.Wing RR, Bolin P, Brancati FL, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145-154.World Health Organization. Obesity. https://www.who.int/health-topics/obesity#tab=tab_1 Listen to more episodes of The Huddle at adces.org/perspectives/the-huddle-podcast.Learn more about ADCES and the many benefits of membership at adces.org/join.

Look out for the Holstein-Lewis Fracture which is associated with radial nerve injury.  Also, be aware of the torsional forces associated with arm wrestling.   Check out the paper mention Moloney DP, Feeley I, Hughes AJ, Merghani K, Sheehan E, Kennedy M. Injuries associated with arm wrestling: A narrative review. J Clin Orthop Trauma. 2021 Apr 20;18:30-37. doi: 10.1016/j.jcot.2021.04.010. Erratum in: J Clin Orthop Trauma. 2021 Jul 30;20:101539. doi: 10.1016/j.jcot.2021.101539. PMID: 33996446; PMCID: PMC8091050.   Check out the Radiopaedia page  Lustosa L, Campos A, Bell D, et al. Holstein-Lewis fracture. Reference article, Radiopaedia.org (Accessed on 23 Jan 2025) https://doi.org/10.53347/rID-99967   Check out the OrthoBullets page by Kellish and Weatherford     www.rnzcuc.org.nz podcast@rnzcuc.org.nz https://www.facebook.com/rnzcuc https://twitter.com/rnzcuc   Music licensed from www.premiumbeat.com Full Grip by Score Squad   This podcast is intended to assist in ongoing medical education and peer discussion for qualified health professionals.  Please ensure you work within your scope of practice at all times.  For personal medical advice always consult your usual doctor 

In this episode, we are joined by Michael Macklin, MD, PharmD, Assistant Professor of Medicine at the University of Chicago, to discuss the teams in the Cytokine Crushers region of RheumMadness 2025, the Innovation Invitational.This is part 1 of the conversation, where we go in depth about the long-term outcomes of anifrolumab in SLE study and give a primer about type 1/2 cytokines so you're ready to dig into the TYK2 in SLE and Oral Anti-IL23 studies.Join us again next week for part 2 of this discussion to learn more about this region.Links to the Cytokine Crushers Scouting Reports:Oral anti-IL23, by collaborating Chicago area rheumatology fellowship programs (Loyola, Northwestern, and the University of Chicago)Long-term outcomes of anifrolumab in SLE, by the Medical University of South Carolina (MUSC) Adult Rheumatology FellowshipTYK2 inhibitor in SLE, by the University of North Carolina (UNC) Adult Rheumatology FellowshipLinks to old scouting reports and other studies referenced in this podcast:TULIP 1/2 scouting report from RheumMadness 2021LLDAS scouting report from RheumMadness 2024Morand EF, Abreu G, Furie RA, Golder V, Tummala R. Lupus low disease activity state attainment in the phase 3 TULIP trials of anifrolumab in active systemic lupus erythematosus. Ann Rheum Dis. 2023 May;82(5):639-645. doi: 10.1136/ard-2022-222748. Epub 2023 Jan 23. Erratum in: Ann Rheum Dis. 2024 Apr 11;83(5):e12. doi: 10.1136/ard-2022-222748corr1. PMID: 36690388; PMCID: PMC10176410.Tanaka Y. Viewpoint on anifrolumab in patients with systemic lupus erythematosus and a high unmet need in clinical practice. RMD Open. 2023 Aug;9(3):e003270. doi: 10.1136/rmdopen-2023-003270. Erratum in: RMD Open. 2024 Apr 4;10(2):e003270corr1. doi: 10.1136/rmdopen-2023-003270corr1. PMID: 37597847; PMCID: PMC10441065.ORAL Surveillance scouting report from RheumMadness 2024To learn more about RheumMadness:https://sites.duke.edu/rheummadness/Subscribe to our newsletter:https://lists.duke.edu/sympa/subscribe/rheummadnessFind us on social media:Bluesky: @rheummadness.bsky.socialInstagram: https://www.instagram.com/rheummadness/X: Follow #RheumMadnessIntro/outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/

L'agriculture. Comme le cœur, qui n'en a pas, en meurt. Fin 2024, le Shift a enfin dévoilé son rapport sur le secteur. Et c'est une première, il a intégré dans son logiciel une grande enquête auprès de la population agricole. Alors que pensent les agriculteurs de la transition écologique? On vous dévoile tout dans Time To Shift.Pour avoir (beaucoup) + de détails, retrouvez l'ensemble des documents de compte-rendu de cette grande enquête ici: https://theshiftproject.org/article/resultats-grande-consultation-des-agriculteurs/Erratum: contrairement à ce qui est dit dans l'épisode, le nombre de chefs d'exploitations est de l'ordre de 400 000 personnes, pas 300 000 . Ce qui ne change rien à la solidité de l'enquête.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Among patients with colorectal cancer and synchronous liver metastases, the subgroup with a primary cancer in the rectum is especially challenging. Compared with colon cancer, most patients with stage IV rectal cancer will have locally advanced primary tumors at increased risk for obstructive and/or post-operative complications resulting in delays in systemic therapy. In this episode from the HPB team at Behind the Knife, listen in on the discussion about treatment sequencing for synchronous liver metastasis from rectal cancer Hosts Anish J. Jain MD (@anishjayjain) is a current PGY3 General Surgery Resident at Stanford University and a former T32 Research Fellow at the University of Texas MD Anderson Cancer Center. Timothy E. Newhook MD, FACS (@timnewhook19) is an Assistant Professor within the Department of Surgical Oncology. He is also the associate program director of the HPB fellowship at the University of Texas MD Anderson Cancer Center.  Jean-Nicolas Vauthey MD, FACS (@VautheyMD) is Professor of Surgery and Chief of the HPB Section, as well as the Dallas/Fort Worth Living Legend Chair of Cancer Research in the Department of Surgical Oncology at The University of Texas MD Anderson Cancer Center. Learning Objectives ·      Develop an understanding of the three treatment sequences for resection of disease in patients with synchronous liver metastasis from a primary rectal cancer (reverse, combined, and classic approach) ·      Develop an understanding of the benefits, risks, and nuances of each of the three treatment sequences ·      Develop an understanding of which patient cases each treatment sequence is ideal for as well as which cases they are not suitable for. Papers Referenced (in the order they were mentioned in the episode): 1)    Conrad C, Vauthey JN, Masayuki O, et al. Individualized Treatment Sequencing Selection Contributes to Optimized Survival in Patients with Rectal Cancer and Synchronous Liver Metastases. Ann Surg Oncol. 2017 Dec;24(13):3857-3864.  https://pubmed.ncbi.nlm.nih.gov/28929463/ 2)    Maki H, Ayabe RI, Nishioka Y, et al. Hepatectomy Before Primary Tumor Resection as Preferred Approach for Synchronous Liver Metastases from Rectal Cancer. Ann Surg Oncol. 2023 Sep;30(9):5390-5400. doi: 10.1245/s10434-023-13656-4. Epub 2023 Jun 7. Erratum in: Ann Surg Oncol. 2023 Sep;30(9):5405. https://pubmed.ncbi.nlm.nih.gov/37285096/ Additional Suggested Reading Mentha G, Majno PE, Andres A, Rubbia-Brandt L, Morel P, Roth AD. Neoadjuvant chemotherapy and resection of advanced synchronous liver metastases before treatment of the colorectal primary. Br J Surg. 2006 Jul;93(7):872-8.  https://pubmed.ncbi.nlm.nih.gov/16671066/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

It's the end of the year, and time for our annual holiday break here at Mindscape. But as usual, we wrap up with a Holiday Message. This year, inspired by Joni Mitchell's "Hits" and "Misses" albums, I go through my scientific papers and talk about some of my favorites -- some of which were hits, in terms of making an impact on subsequent research, and some of which were misses by that standard. But I love them all! It's an excuse to talk about process -- how papers come to be, from the initial informal idea to sitting down and doing the work.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/23/holiday-message-hits-and-misses/Here are links to the papers I discuss in the episode.S.M. Carroll, G.B. Field and R. Jackiw, 1990, "Limits on A Lorentz and Parity-Violating Modification of Electrodynamics,'' Phys. Rev. D 41, 1231. [pdf file; inSPIRE]S.M. Carroll, E. Farhi and A.H. Guth, 1992, "An Obstacle to Building a Time Machine,'' Phys. Rev. Lett. 68, 263; Erratum: 68, 3368. [pdf file; inSPIRE]S.M. Carroll, E. Farhi, A.H. Guth and K.D. Olum, 1994, "Energy-Momentum Restrictions on the Creation of Gott Time Machines,'' Phys. Rev. D 50, 6190; gr-qc/9404065. [arXiv; pdf; inSPIRE]S.M. Carroll, 1998, "Quintessence and the Rest of the World,'' Phys. Rev. Lett. 81, 3067; astro-ph/9806099. [arXiv; pdf; inSPIRE]S.M. Carroll, V. Duvvuri, M. Trodden, and M.S. Turner, 2003, "Is Cosmic Speed-Up Due to New Gravitational Physics?'' astro-ph/0306438. [arXiv; pdf; inSPIRE]S.M. Carroll and J. Chen, 2004, "Spontaneous Inflation and the Origin of the Arrow of Time'', hep-th/0410270. [arXiv, inSPIRE]L. Ackerman, M.R. Buckley, S.M. Carroll, and M. Kamionkowski, 2008, "Dark Matter and Dark Radiation," arxiv:0807.5126. [arXiv; pdf; inSPIRE]S.M. Carroll, M.C. Johnson, and L. Randall, 2009, "Dynamical Compactification," arxiv:0904.3115. [arXiv; pdf; inSPIRE]C. Cao, S.M. Carroll, and S. Michalakis, 2016, "Space from Hilbert Space: Recovering Geometry from Bulk Entanglement," arxiv:1606.08444. [arXiv, inSPIRE]C. Cao and S.M. Carroll, 2018, "Bulk Entanglement Gravity without a Boundary: Towards Finding Einstein's Equation in Hilbert Space," arxiv:1712.02803. [arXiv, inSPIRE]N. Bao, S.M. Carroll, A. Chatwin-Davies, J. Pollack, and G. Remmen, 2017, “Branches of the Black Hole Wave Function Need Not Contain Firewalls," arxiv:1712.04955. [arXiv, inSPIRE]See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In the second episode our three part series, we dive deeper into the practical impact of artificial intelligence on emergency medicine with expert, Dr. Gabriel Wardi. Building on our previous discussion about AI's role in healthcare, we explore clinical decision support systems (CDS)—how they aim to improve diagnostic accuracy but can sometimes miss the mark. Dr. Wardi shares insights from his own experience implementing AI-driven CDS, highlighting both its successes and challenges, including bias, reliability, and the importance of high-quality data. We discuss how AI can address traditional pitfalls of CDS, improve outcomes like sepsis care, and offer a glimpse into the future of AI in emergency settings. Plus, we look ahead to the critical conversation of AI governance and regulation in EM. Tune in as we break down what's working, what's next, and how frontline EM physicians can stay ahead of the curve. How are you using AI in your ED? What are your concerns and hopes for the future of AI in medicine? Keep the discussion going on social media @empulsepodcast or at ucdavisem.com Hosts: Dr. Julia Magaña, Professor of Pediatric Emergency Medicine at UC Davis Dr. Sarah Medeiros, Associate Professor of Emergency Medicine at UC Davis Guest: Dr. Gabriel Wardi, Associate Professor & Chief of the Division of Critical Care in the Department of Emergency Medicine at UC San Diego Resources: Boussina A, Shashikumar SP, Malhotra A, Owens RL, El-Kareh R, Longhurst CA, Quintero K, Donahue A, Chan TC, Nemati S, Wardi G. Impact of a deep learning sepsis prediction model on quality of care and survival. NPJ Digit Med. 2024 Jan 23;7(1):14. doi: 10.1038/s41746-023-00986-6. Erratum in: NPJ Digit Med. 2024 Jun 12;7(1):153. doi: 10.1038/s41746-024-01149-x. PMID: 38263386; PMCID: PMC10805720. *** Thank you to the UC Davis Department of Emergency Medicine for supporting this podcast and to Orlando Magaña at OM Productions for audio production services.

A 67 year old woman with a history of hypertension, hyperlipidemia, diabetes, and a 25 pack year smoking history is referred your clinic and is referred for evaluation of her peripheral arterial disease. She reports pain with walking that has limited her doing some daily activities. How can you optimally manage this patient? Does she need an operation? In this episode, we will cover the basics of peripheral arterial disease, discuss the specifics of optimal medical management and dive into the nuances of when (or if) you should offer these patients an operation.  Hosts:  Dr. Bobby Beaulieu is an Assistant Professor of Vascular Surgery at the University of Michigan and the Program Director of the Integrated Vascular Surgery Residency Program as well as the Vascular Surgery Fellowship Program at the University of Michigan. Dr. Drew Braet is a PGY-5 Integrated Vascular Surgery Resident at the University of Michigan Learning Objectives - Review the definition, prevalence, and risk factors for peripheral arterial disease - Understand the specifics of optimal medical management of patients with peripheral arterial disease  - Discuss the controversy regarding operative management of patients with claudication and review indications for an operation in patients with peripheral arterial disease - Review the appropriate anti-platelet and anti-coagulation strategies after interventions in patients with peripheral arterial disease References 1.    Woo K, Siracuse JJ, Klingbeil K, Kraiss LW, Osborne NH, Singh N, Tan TW, Arya S, Banerjee S, Bonaca MP, Brothers T, Conte MS, Dawson DL, Erben Y, Lerner BM, Lin JC, Mills JL Sr, Mittleider D, Nair DG, O'Banion LA, Patterson RB, Scheidt MJ, Simons JP; Society for Vascular Surgery Appropriateness Committee. Society for Vascular Surgery appropriate use criteria for management of intermittent claudication. J Vasc Surg. 2022 Jul;76(1):3-22.e1. doi: 10.1016/j.jvs.2022.04.012. Epub 2022 Apr 22. PMID: 35470016. https://pubmed.ncbi.nlm.nih.gov/35470016/ 2.    Nordanstig J, Behrendt CA, Baumgartner I, Belch J, Bäck M, Fitridge R, Hinchliffe R, Lejay A, Mills JL, Rother U, Sigvant B, Spanos K, Szeberin Z, van de Water W; ESVS Guidelines Committee; Antoniou GA, Björck M, Gonçalves FB, Coscas R, Dias NV, Van Herzeele I, Lepidi S, Mees BME, Resch TA, Ricco JB, Trimarchi S, Twine CP, Tulamo R, Wanhainen A; Document Reviewers; Boyle JR, Brodmann M, Dardik A, Dick F, Goëffic Y, Holden A, Kakkos SK, Kolh P, McDermott MM. Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Asymptomatic Lower Limb Peripheral Arterial Disease and Intermittent Claudication. Eur J Vasc Endovasc Surg. 2024 Jan;67(1):9-96. doi: 10.1016/j.ejvs.2023.08.067. Epub 2023 Nov 10. PMID: 37949800. https://pubmed.ncbi.nlm.nih.gov/37949800/ 3.    Gornik HL, Aronow HD, Goodney PP, Arya S, Brewster LP, Byrd L, Chandra V, Drachman DE, Eaves JM, Ehrman JK, Evans JN, Getchius TSD, Gutiérrez JA, Hawkins BM, Hess CN, Ho KJ, Jones WS, Kim ESH, Kinlay S, Kirksey L, Kohlman-Trigoboff D, Long CA, Pollak AW, Sabri SS, Sadwin LB, Secemsky EA, Serhal M, Shishehbor MH, Treat-Jacobson D, Wilkins LR. 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024 Jun 11;149(24):e1313-e1410. doi: 10.1161/CIR.0000000000001251. Epub 2024 May 14. PMID: 38743805. https://pubmed.ncbi.nlm.nih.gov/38743805/ 4.    Belch JJ, Dormandy J; CASPAR Writing Committee; Biasi GM, Cairols M, Diehm C, Eikelboom B, Golledge J, Jawien A, Lepäntalo M, Norgren L, Hiatt WR, Becquemin JP, Bergqvist D, Clement D, Baumgartner I, Minar E, Stonebridge P, Vermassen F, Matyas L, Leizorovicz A. Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trial. J Vasc Surg. 2010 Oct;52(4):825-33, 833.e1-2. doi: 10.1016/j.jvs.2010.04.027. Epub 2010 Aug 1. Erratum in: J Vasc Surg. 2011 Feb;53(2):564. Biasi, B M [corrected to Biasi, G M]. PMID: 20678878. https://pubmed.ncbi.nlm.nih.gov/20678878/ 5.    Eikelboom JW, Connolly SJ, Bosch J, Dagenais GR, Hart RG, Shestakovska O, Diaz R, Alings M, Lonn EM, Anand SS, Widimsky P, Hori M, Avezum A, Piegas LS, Branch KRH, Probstfield J, Bhatt DL, Zhu J, Liang Y, Maggioni AP, Lopez-Jaramillo P, O'Donnell M, Kakkar AK, Fox KAA, Parkhomenko AN, Ertl G, Störk S, Keltai M, Ryden L, Pogosova N, Dans AL, Lanas F, Commerford PJ, Torp-Pedersen C, Guzik TJ, Verhamme PB, Vinereanu D, Kim JH, Tonkin AM, Lewis BS, Felix C, Yusoff K, Steg PG, Metsarinne KP, Cook Bruns N, Misselwitz F, Chen E, Leong D, Yusuf S; COMPASS Investigators. Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease. N Engl J Med. 2017 Oct 5;377(14):1319-1330. doi: 10.1056/NEJMoa1709118. Epub 2017 Aug 27. PMID: 28844192. https://pubmed.ncbi.nlm.nih.gov/28844192/ 6.    Bonaca MP, Bauersachs RM, Anand SS, Debus ES, Nehler MR, Patel MR, Fanelli F, Capell WH, Diao L, Jaeger N, Hess CN, Pap AF, Kittelson JM, Gudz I, Mátyás L, Krievins DK, Diaz R, Brodmann M, Muehlhofer E, Haskell LP, Berkowitz SD, Hiatt WR. Rivaroxaban in Peripheral Artery Disease after Revascularization. N Engl J Med. 2020 May 21;382(21):1994-2004. doi: 10.1056/NEJMoa2000052. Epub 2020 Mar 28. PMID: 32222135. https://pubmed.ncbi.nlm.nih.gov/32222135/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

Sarah Bergeron-Larouche est de retour au podcast pour partager les moments forts de sa saison 2024! Après plus d'une décennie à dominer la scène canadienne du trail, elle s'est lancée dans sa plus grande aventure : la maternité. Avec toute l'authenticité et l'énergie contagieuse qu'on lui connaît, Sarah nous raconte comment elle a maintenu sa pratique sportive pendant sa grossesse, et planifié son retour à la compétition après la naissance de sa petite Nina. Elle revient en détail sur sa victoire au 50 km du Grindstone Running Festival by UTMB, qui lui ouvre les portes de l'Ultra-trail du Mont-Blanc (UTMB) en 2025. On jase également des réalités de voyager avec un bébé, et notamment de leur hiver dernier passé à Gérone en Espagne, la mecque du cyclisme et du plein air. Dans l'épisode, Sarah se confie sur les défis de son retour à la compétition et tous les bienfaits que la parentalité a apporté à sa pratique sportive. Une jasette inspirante avec une athlète généreuse et passionnée. Bonne écoute!*ERRATUM : À la 60e minute de l'épisode, je mentionne que Mélodie Gilbert a terminé 7e à Istria By UTMB en 2023, mais elle a plutôt terminé 2e. Mes excuses, Mélo!CréditsDesign graphique : David HébertThème musical : Frédérick DesrochesIdée originale, production, recherche et animation : Yannick Vézina© Pas sorti du bois 2024

Le homard ça coûte vraiment pas cher, pis en plus c't'une nourriture de pauvre. Heille, ça ne vaut tellement rien qu'on en trouve un peu partout sur les côtes, on peut en pêcher à main nue dans l'eau peu profonde. Ceux qui en mangent ont même honte, et avec les restes, on fait de l'engrais. Avouez qu'on dirait qu'on est dans une réalité parallèle. Pourtant, c'est bien comme ça qu'on considérait le homard il n'y a pas si longtemps que ça. Alors, la question qu'on peut se poser c'est, comment se fait-il qu'aujourd'hui, le homard est associé à un mets gastronomique ? ERRATUM: 4:57, le viandier de Taillevent et non le vivandier! Merci à un fidèle abonné @manflame321 . A NOTER: Aussi la fresque de Pompéi représente une langouste et non un homard, une espèce à part. La langouste commune en France est la langouste rouge ou langouste commune, Palinurus elephas, de la famille des Palinuridae (langoustes) variété bien distincte des homards. Adhérez à cette chaîne pour obtenir des avantages : https://www.youtube.com/channel/UCN4TCCaX-gqBNkrUqXdgGRA/join Images de drone par L'Île Imagin'air: https://www.tourismeilesdelamadeleine.com/fr/l-ile-imagin-air/photographie-et-videos/ Lieux visités: Interprétation pêche en mer https://www.tourismeilesdelamadeleine.com/fr/interpretation-peche-en-mer/peche/ Cap Dauphin - Coopérative des Pêcheurs https://www.tourismeilesdelamadeleine.com/fr/fish-shack/visite-industrielle/ Un grand merci aux pêcheurs Maxime Poirier, Daniel LeBlanc, et Éric Langlois, à Tourisme Iles de la Madeleine et Madame Ruth Taker-Thibodeau de la Coopérative des Pêcheurs. Un grand merci aussi à Robin-Joël Cool (https://agenceduchesne.com/288--robin-joel-cool) Voici le lien vers sa chanson: https://45tours.ca/single/jveux-du-homard-avec-la-recette-des-iles   Pour soutenir la chaîne, au choix: 1. Cliquez sur le bouton « Adhérer » sous la vidéo. 2. Patreon: https://www.patreon.com/hndl Musique issue du site : epidemicsound.com Images provenant de https://www.storyblocks.com Abonnez-vous à la chaine: https://www.youtube.com/c/LHistoirenousledira Les vidéos sont utilisées à des fins éducatives selon l'article 107 du Copyright Act de 1976 sur le Fair-Use. Sources et pour aller plus loin: Elisabeth Townsend, Lobster. A Global History, London, Reaktion Books, 2011. Trevor Corson, The Secret life of Lobster, New York, 2004. Ehud Spanier et al. « A concise review of lobster utilization by worldwide human populations from prehistory to the modern era », ICES Journal of Marine Science, 72, 2015, p. i7-i21. doi:10.1093/icesjms/fsv066 Ehud Spanier, « The Utilization of Lobsters by Humans in the Mediterranean Basin from the Prehistoric Era to the Modern Era – An Interdisciplinary Short Review », Athens Journal of Mediterranean Studies, Volume 1, Issue 3, 2015, p. 223-234. Éric de Benedictis, « La folle histoire du homard, des origines à nos tables », Vice, 23 décembre 2015. https://www.vice.com/fr/article/xy7vzw/la-folle-histoire-du-homard-des-origines-a-nos-tables Daniel Luzer, « How Lobster got Fancy », Pacific Standard, 14 juin 2017. https://psmag.com/economics/how-lobster-got-fancy-59440 Eliane Bourque, « Les humbles origines du homard, d'aliment snobé à plat de luxe », Mordu, Radio-Canada, 6 mai 2021. https://ici.radio-canada.ca/mordu/2418/histoire-homard-canada-gaspesie Bref historique de la pêche du homard dans le sud du golfe du Saint-Laurent : Fs149-6/2012F-PDF ; Ottawa - Ontario : Pêches et Océans Canada. c2012 Véronique Leduc, « 8 choses que vous ne savez (peut-être) pas sur le homard », Avenue.ca, 22 mai 2018. https://avenues.ca/savourer/saveur/8-choses-sur-le-homard-du-quebec/ Marina Santos, « Lobster Lore », 11 mai 2021. https://seagrant.mit.edu/wp-content/uploads/2021/06/Lobster_Lore_Print.pdf « Homard », Wikipédia. https://fr.wikipedia.org/wiki/Homard Hélène Raymond, Portraits du Saint-Laurent. Histoire des pêches et récits maritimes, Montréal, Multimondes, 2024. Autres références disponibles sur demande. #histoire #documentaire #homard #lobster #ilesdelamadeleine #pêche #Robinjoelcool

In this episode, Lauren and Matt talk with Leah Richmond-Rakerd, PhD who is an Assistant Professor in the Department of Psychology at the University of Michigan. Her research focuses on emotional and behavioral dysregulation across the life course. Here, Dr. Richmond-Rakerd will discuss her recent study on “The Associations of Hospital-Treated Infections with Subsequent Dementia: Nationwide 30-year Analysis” that was published in Nature Aging. Articles Discussed in Episode: Richmond-Rakerd LS, Iyer MT, D'Souza S, Khalifeh L, Caspi A, Moffitt TE, Milne BJ. Associations of hospital-treated infections with subsequent dementia: nationwide 30-year analysis. Nat Aging. 2024 Jun;4(6):783-790. doi: 10.1038/s43587-024-00621-3. Epub 2024 May 7. PMID: 38714911. Milne BJ, Atkinson J, Blakely T, Day H, Douwes J, Gibb S, Nicolson M, Shackleton N, Sporle A, Teng A. Data Resource Profile: The New Zealand Integrated Data Infrastructure (IDI). Int J Epidemiol. 2019 Jun 1;48(3):677-677e. doi: 10.1093/ije/dyz014. Erratum in: Int J Epidemiol. 2019 Jun 1;48(3):1027. doi: 10.1093/ije/dyz054. PMID: 30793742. NZ Integrated Data Infrastructure: https://www.stats.govt.nz/integrated-data/integrated-data-infrastructure/ Visit the Center to Accelerate Population Research in Alzheimer's (CAPRA) website to learn more. The transcript for this episode can be found here.You can subscribe to Minding Memory on Apple Podcasts, Spotify, or wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.

Acetaminophen overdose is one of the most common medication concerns we see in the ED. It is important to know when to be concerned and when to treat as true overdoses can cause liver failure and death. UC Davis medical toxicologist, Dr. Hoan Nguyen, joins us in this episode to discuss a new consensus statement published in JAMA Network Open in August 2023: Managing of Acetaminophen Poisoning in the US and Canada. We discuss the updated approach and walk through as hypothetical case. At the end of this episode, you'll be able to identify high risk patients, know what labs to draw, when to start NAC, transfer, and call your local toxicologist. Do these updated guidelines change your practice? Hit us up on social media @empulsepodcast or at ucdavisem.com Hosts: Dr. Julia Magaña, Professor of Pediatric Emergency Medicine at UC Davis Dr. Sarah Medeiros, Associate Professor of Emergency Medicine at UC Davis Guests: Dr. HoanVu Nguyen, Military Emergency Physician and Medical Toxicologist at UC Davis.  Resources: Dart RC, Mullins ME, Matoushek T, et al. Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement. JAMA Netw Open. 2023 Aug 1;6(8):e2327739. doi: 10.1001/jamanetworkopen.2023.27739. Erratum in: JAMA Netw Open. 2023 Sep 5;6(9):e2337926. doi: 10.1001/jamanetworkopen.2023.37926. PMID: 37552484. ***** Thank you to the UC Davis Department of Emergency Medicine for supporting this podcast and to Orlando Magaña at OM Productions for audio production services.

Why stop emitting when we can just plant a bunch of trees?BONUS EPISODES available on Patreon (https://www.patreon.com/deniersplaybook) SOCIALS & MORE (https://linktr.ee/deniersplaybook) CREDITS Created by: Rollie Williams, Nicole Conlan & Ben BoultHosts: Rollie Williams & Nicole ConlanExecutive Producer: Ben Boult Post-production: Jubilaria Media Researchers: Carly Rizzuto, Canute Haroldson & James Crugnale Art: Jordan Doll Music: Tony Domenick Special thanks: The Civil Liberties Defense Center, Shelley Vinyard & The National Resources Defense Council, Angeline Robertson & Stand.EarthSOURCESMrBeast. (2019). Planting 20,000,000 Trees, My Biggest Project Ever! YouTube.Charmin. (2022, January 31). Protect Grow Restore | Charmin® Loves Trees. YouTube.CNBC Television. (2020, January 21). Watch President Donald Trump's full speech at the Davos World Economic Forum. YouTube.Carrington, D. (2019, July 4). Tree planting “has mind-blowing potential” to tackle climate crisis. 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(2020, March 11). Is the GOP warming to climate action? Trillion trees plan hopes for growth. YouTube.Speaker Kevin McCarthy. (2023, June 29). Speaker McCarthy and House Republicans Fight For American-Made Energy in Columbiana County, Ohio. YouTube.Sen. Mike Braun - Indiana. (2024). Open SecretsRep. Buddy Carter - Georgia (District 01). (2024). Open Secrets.Rep. Kevin McCarthy - California (District 23). (2024). Open Secrets.Rep. Clay Higgins - Louisiana (District 03). (2024). Open Secrets.Rep. Bruce Westerman - Arkansas (District 04). (2024). Open Secrets.Actions - H.R.2639 - 117th Congress (2021-2022): Trillion Trees Act. (n.d.). Congress.gov.2023 National ECongress.govnvironmental Scorecard. (2023). League of Conservation Voters.Heal, A. (2023, April 11). The illusion of a trillion trees. The Financial Times Limited.Veldman, J. W., Aleman, J. C., Alvarado, S. T., Anderson, T. M., Archibald, S., Bond, W. J., Boutton, T. W., Buchmann, N., Buisson, E., Canadell, J. G., Dechoum, M. de S., Diaz-Toribio, M. H., Durigan, G., Ewel, J. J., Fernandes, G. W., Fidelis, A., Fleischman, F., Good, S. P., Griffith, D. M., & Hermann, J.-M. (2019). Comment on “The global tree restoration potential.” Science, 366(6463). https://doi.org/10.1126/science.aay7976.Erratum for the Report: “The global tree restoration potential” by J.-F. Bastin, Y. Finegold, C. Garcia, D. Mollicone, M. Rezende, D. Routh, C. M. Zohner, T. W. Crowther and for the Technical Response “Response to Comments on ‘The global tree restoration potential'” by J.-F. Bastin, Y. Finegold, C. Garcia, N. Gellie, A. Lowe, D. Mollicone, M. Rezende, D. Routh, M. Sacande, B. Sparrow, C. M. Zohner, T. W. Crowther. (2020). Science, 368(6494). https://doi.org/10.1126/science.abc8905Anderson, T. R., Hawkins, E., & Jones, P. D. (2016). CO2, the greenhouse effect and global warming: from the pioneering work of Arrhenius and Callendar to today's Earth System Models. Endeavour, 40(3), 178–187. https://doi.org/10.1016/j.endeavour.2016.07.002Hasler, N., Williams, C. A., Vanessa Carrasco Denney, Ellis, P. W., Shrestha, S., Terasaki, D. E., Wolff, N. H., Yeo, S., Crowther, T. W., Werden, L. K., & Cook-Patton, S. C. (2024). Accounting for albedo change to identify climate-positive tree cover restoration. Nature Communications, 15. https://doi.org/10.1038/s41467-024-46577-1Viani, R. A. G., Bracale, H., & Taffarello, D. (2019). Lessons Learned from the Water Producer Project in the Atlantic Forest, Brazil. Forests, 10(11), 1031. https://doi.org/10.3390/f10111031Vadell, E., de-Miguel, S., & Pemán, J. (2016). Large-scale reforestation and afforestation policy in Spain: A historical review of its underlying ecological, socioeconomic and political dynamics. Land Use Policy, 55, 37–48. https://doi.org/10.1016/j.landusepol.2016.03.017TED-Ed. (2023, December 19). Does planting trees actually cool the planet? - Carolyn Beans. YouTube.Howard, S. Q.-I., Emma, & Howard, E. (2022, December 12). “How are we going to live?” Families dispossessed of their land to make way for Total's Congo offsetting project. Unearthed.Garside, R., & Wyn, I. (2021, August 6). Tree-planting: Why are large investment firms buying Welsh farms? BBC News.Gabbatiss, J., & Viisainen, V. (2024, June 26). Analysis: UK misses tree-planting targets by forest the “size of Birmingham.” Carbon Brief.Buller, A. (2022). The Value of a Whale. Manchester University Press.Alexander, S. (2024, May 3). A Billionaire Wanted to Save 1 Trillion Trees by 2030. It's Not Going Great. Bloomberg.No Watermark Clips. (2019, May 21). King of the Hill on Carbon Offsets. YouTube.Choi-Schagrin, W. (2021, August 23). Wildfires are ravaging forests set aside to soak up greenhouse gases. The New York Times.Hodgson, C. (2021, August 4). US Forest Fires Threaten Carbon Offsets as Company-Linked Trees Burn. Inside Climate News.What's the potential of a trillion trees? (2020). Crowther Lab.Luhn, A. (2023, December 13). Stop Planting Trees, Says Guy Who Inspired World to Plant a Trillion Trees. Wired.TED Audio Collective. (2022, July 3). Can planting trees really stop climate change? | Thomas Crowther | The TED Interview. YouTube.Fleischman, F., Basant, S., Chhatre, A., Coleman, E. A., Fischer, H. W., Gupta, D., Güneralp, B., Kashwan, P., Khatri, D., Muscarella, R., Powers, J. S., Ramprasad, V., Rana, P., Solorzano, C. R., & Veldman, J. W. (2020). Pitfalls of Tree Planting Show Why We Need People-Centered Natural Climate Solutions. BioScience, 70(11). https://doi.org/10.1093/biosci/biaa094Oglesby, C. (2021, Feb 9). Republicans want to plant 1 trillion trees — and then log them. GristCORRECTIONSFelix Finkbeiner was 13 years old when he spoke at the United Nations, not 12.The industry that has currently contributed the most to Rep. Bruce Westerman's career campaigns for federal congress is the Forestry & Forest Products industry, as reported by Open Secrets. The Oil & Gas industry is listed as #2.DISCLAIMER: Some media clips have been edited for length and clarity.[For sponsorship inquiries, please contact climatetown@no-logo.co]See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Please enjoy this monologue of mine about OMT and bowel function! I share some personal stories and successes in treating constipation with OMT and then dive into my own process for assessment and recommendations for patients struggling with bowel regularity. Additionally, I share some of my personal thoughts about two articles related to the topic. Find the articles I referenced and reviewed cited below: Belvaux A, Bouchoucha M, Benamouzig R. Osteopathic management of chronic constipation in women patients. Results of a pilot study. Clin Res Hepatol Gastroenterol. 2017 Oct;41(5):602-611. doi: 10.1016/j.clinre.2016.12.003. Epub 2017 Feb 16. PMID: 28215390. Baltazar GA, Betler MP, Akella K, Khatri R, Asaro R, Chendrasekhar A. Effect of osteopathic manipulative treatment on incidence of postoperative ileus and hospital length of stay in general surgical patients. J Am Osteopath Assoc. 2013 Mar;113(3):204-9. Erratum in: J Am Osteopath Assoc. 2013 Apr;113(4):271. PMID: 23485980. Dr. Jordan Little, D.O. - jordanlittle.do@gmail.com ONMM Podcast - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠onmmpodcast@gmail.com

Le Moyen-Âge est rempli de clichés. Côté nourriture, on est plusieurs à avoir l'image de Jacquouille la fripouille qui se goinfre de nourriture en mangeant par terre. ERRATUM: 9:07, cardamome et non cardamone;12:26, queux comme dans maître-queux; et 13:55, asseoir bien sûr, comme s'asseoir, merci aux fidèles abonnés qui scrutent tout! Adhérez à cette chaîne pour obtenir des avantages : https://www.youtube.com/channel/UCN4TCCaX-gqBNkrUqXdgGRA/join Script:  @SorcierAmbulant  Avec l'aide de  @LesHistovores  Pour soutenir la chaîne, au choix: 1. Cliquez sur le bouton « Adhérer » sous la vidéo. 2. Patreon: https://www.patreon.com/hndl Musique issue du site : epidemicsound.com Images provenant de https://www.storyblocks.com Abonnez-vous à la chaine: https://www.youtube.com/c/LHistoirenousledira Les vidéos sont utilisées à des fins éducatives selon l'article 107 du Copyright Act de 1976 sur le Fair-Use. Sources et pour aller plus loin: Histoire de l'alimentation, Paris, Fayard, 1996, ouvrage collectif codirigé avec Massimo Montanari. Alban Gautier, Alimentations médiévales. Ve – XVIe siècles, Paris, Ellipses Marketing, coll. « Le monde : une histoire », 2009 Jean Verdon, Boire au Moyen Âge, Perrin, coll. « Pour l'histoire », 2002. Odile Redon, Françoise Sabban et Silvano Serventi, La Gastronomie au Moyen Âge. 150 recettes de France et d'Italie, Stock, 333 p. Florent Quellier (dir.), Histoire de l'alimentation : de la Préhistoire à nos jours, Paris, Belin, 2021. Carole Lambert, Du manuscrit à la table. Essais sur la cuisine au Moyen Âge, Montréal/Paris, Presses de l'Université de Montréal/Champion, 1992 Bruno Laurioux, Les Livres de cuisine médiévaux, Turnhout, Belgique, 1997, 86 p. (ISBN 978-2503360775). Bruno Laurioux, Manger au Moyen Âge. Pratiques et discours alimentaires en Europe aux xive et xve siècles, Paris, Hachette, 2002 Bruno Laurioux, Une histoire culinaire du Moyen Âge, Paris, Honoré Champion, coll. « Sciences, techniques et civilisations du Moyen ge à l'aube des Lumières », 2005. Que mangeait-on au Moyen Âge ? - Entretien avec Fabian Müllers, Nota Bonus, 4 avril 2023. https://youtu.be/oufXfQ0crNE?si=zo543bHA2_SY4NgM Fabian Müllers, Cuisine historique: le Moyen Âge, La Muse, 2018. C. M. Woolgar, Food in Medieval England : Diet and Nutrition, Oxford University Press, 2006. James Hancock, L'histoire ancienne du clou de girofle, de la noix de muscade et du macis, traduit par Babeth Étiève-Cartwright, publié le 13 octobre 2021, World history encyclopedia en français James Hancock, traduit en français par Babeth Étiève-Carwright, « Commerce mondial au 13e siècle », World history encyclopedia, 2022, Commerce Mondial au 13e Siècle - Encyclopédie de l'Histoire du Monde (worldhistory.org) Marin Wagda, « Les croisades comme facteur d'échanges gastronomiques en Europe », Hommes & Migrations, 1997, p. 160-163. Old Cook, La cuisine du Haut Moyen Age, Marie Josèphe Moncorgé https://www.oldcook.com/histoire-cuisine_haut_moyen_age Le vivandier de Taillevent, 1326-1395 https://gallica.bnf.fr/ark:/12148/bpt6k62367s# Le littré, « assiette », définition https://www.littre.org/definition/assiette Pourquoi, pendant des années, le Vatican a-t-il utilisé le mot "poissons" pour désigner castors et capybaras ? CHARLINE VERGNE , 20/02/2024 à 8h21 - Mis à jour le 20/02/2024 https://www.geo.fr/histoire/pourquoi-pendant-des-annees-le-vatican-a-t-il-utilise-le-mot-poissons-pour-designer-castors-et-capybaras-viande-careme-amerindiens-218897 Manger chrétien, BNF, exposition https://expositions.bnf.fr/gastro/arret_sur/chretien/texte.htm Pain du Moyen-Âge : tout savoir sur le pain médiéval, Anecdotes historiques https://anecdoteshistoriques.com/histoire-medievale/pain-moyen-age/ Des terres et cours impériales, Capitulaire de Charlemagne, Marie Josèphe Moncorgé https://www.oldcook.com/medieval-capitulaire_charlemagne Les épices au Moyen-Âge par Greg de Wal, 30 oct 2019 https://recettemedievale.fr/les-epices-au-moyen-age/ Que mangeait-on au temps des Seigneurs ? Le patrimoine oublié, association du vieux château de Noyers-sur-Serein, 1998-2024 https://lepatrimoineoublie.fr/que-mangeait-on-au-temps-des-seigneurs Wikipedia, la cuisine médiévale https://fr.wikipedia.org/wiki/Cuisine_m%C3%A9di%C3%A9vale Wikipedia, medieval cuisine https://en.wikipedia.org/wiki/Medieval_cuisine Éric Birlouez, Petite et grande histoire des légumes, Versailles, Quæ, coll. « Carnets de sciences », 2020. Autres références disponibles sur demande. #histoire #documentaire #cuisine #cuisinemedievale #moyenage #middleage

A Rebelião Saudável nasceu da união de diversos profissionais de saúde que pensam diferente e cujo foco é promover saúde e bem estar, com comida de verdade e sem medicamentos. Semanalmente a Rebelião se reune no app Telegram para discussão de tópicos importantes relacionados a Nutrição Humana e Qualidade de vida. Nessa semana, falamos sobre Efeito Sanfona.  Os artigos e estudos citados no podcast foram: PONTZER, Herman. Burn: new research blows the lid off how we really burn calories, stay healthy and lose weight. New York: Avery, 2021. D. L. Johannsen et al. (2012). “Metabolic slowing with massive weight loss despite preservation of fat-free mass.” J. Clin. Endocrinol. Metab. 97 (7): 2489–96. doi: 10.1210/jc.2012-1444. E. Fothergill et al. (2016). “Persistent metabolic adaptation 6 years after ‘The Biggest Loser' competition.” Obesity 24 (8): 1612– 19. doi: 10.1002/oby.21538. Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, Chung ST, Costa E, Courville A, Darcey V, Fletcher LA, Forde CG, Gharib AM, Guo J, Howard R, Joseph PV, McGehee S, Ouwerkerk R, Raisinger K, Rozga I, Stagliano M, Walter M, Walter PJ, Yang S, Zhou M. Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake. Cell Metab. 2019 Jul 2;30(1):67-77.e3. doi: 10.1016/j.cmet.2019.05.008. Epub 2019 May 16. Erratum in: Cell Metab. 2019 Jul 2;30(1):226. doi: 10.1016/j.cmet.2019.05.020. Erratum in: Cell Metab. 2020 Oct 6;32(4):690. doi: 10.1016/j.cmet.2020.08.014. PMID: 31105044; PMCID: PMC7946062. A Jornada da Rebelião Saudável chega a sua quarta edição! Adquira seu ingresso em https://rebeliaosaudavel.com.br/compreaqui/ Ajude a rebelião saudável! Seja um apoiador do nosso movimento e garanta que as informações transmitidas continuarão gratuitas para todos! Além de ajudar, você terá acesso a um post mensal exclusivo para apoiadores! Acesse https://apoia.se/rebeliaosaudavel e contribua com a quantia que puder! Ajude a manter esse conteúdo vivo! #facapartedarebeliao Você também pode participar da discussão e da Rebelião. Toda Segunda feira, às 17:00, estaremos ao vivo no Telegram, basta acessar o nosso canal: https://t.me/RebeliaoSaudavel. Se você gosta de nosso trabalho, deixe um review 5 estrelas e faça um comentário no seu app de podcast. Essa atitude é muito importante para a Rebelião saudável e vai ajudar nosso movimento a chegar a cada vez mais pessoas. Você também pode nos acompanhar no instagram, http://www.instagram.com/henriqueautran. E em nosso canal do YouTube: https://youtube.com/c/henriqueautran.

In this episode of The Shoulder Physio podcast, I am joined by Caitlin Jones, who has recently published a world first randomised placebo controlled trial in the Lancet journal on opioids for acute neck and low back pain. In this episode Caitlin discusses why they chose to do this trial, the results and their possible clinical implications. Caitlin also responds to various critiques of the trial with aplomb. Don't miss this enlightening episode with Caitlin Jones. Key Papers: Jones CMP et al. OPAL Investigators Coordinators. Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial. Lancet. 2023 Jul 22;402(10398):304-312. doi: 10.1016/S0140-6736(23)00404-X. Epub 2023 Jun 28. Erratum in: Lancet. 2023 Aug 19;402(10402):612. doi: 10.1016/S0140-6736(23)01681-1. PMID: 37392748. Check out the Shoulder Physio Online Course here Connect with Jared and guests: Jared on Instagram: @‌shoulder_physio Jared on Twitter: @‌jaredpowell12 Caitlin on Twitter: @caitlin_jones See our Disclaimer here: The Shoulder Physio - Disclaimer

Dr. Witkin from the American Society of Retina Specialists talks about our current knowledge of the incidence of retinal vasculitis following intravitreal injection of Pegcetacoplan for treatment of geographic atrophy. Discussed article: Witkin AJ, Jaffe GJ, Srivastava SK, Davis JL, Kim JE. Retinal Vasculitis After Intravitreal Pegcetacoplan: Report From the ASRS Research and Safety in Therapeutics (ReST) Committee. J Vitreoretin Dis. 2023 Dec 21;8(1):9-20. doi: 10.1177/24741264231220224. Erratum in: J Vitreoretin Dis. 2024 Feb 29;8(3):363. doi: 10.1177/24741264241238212. PMID: 38223782; PMCID: PMC10786078.

Pregnancy leads to many physiologic changes, and thyroid and parathyroid disorders alter that physiology even more leading to complex laboratory interpretation and decision-making impacting both mother and fetus. In this episode, join endocrine surgeons Drs. Barb Miller, John Phay, Priya Dedhia, and Surgical Oncology Fellow Dr. Vennila Padmanaban from The Ohio State University. Hear about normal and abnormal thyroid and parathyroid physiology and treatment of patients with thyroid cancer. The group discusses several articles focusing on current guidelines from the American Thyroid Association as well as other key studies.  Hosts: Barbra S. Miller, MD (Moderator), Clinical Professor of Surgery, John Phay, MD, Clinical Professor of Surgery, Priya H. Dedhia, MD, PhD, Assistant Professor of Surgery, Vennila Padmanaban, MD, Surgical Oncology Fellow, Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Twitter handles:  Barbra Miller - @OSUEndosurgBSM John Phay – @JohnPhayMD Priya Dedhia – @priyaknows  Vennila Padmanaban - @vennilapadmanMD Learning objectives:  1)  Understand normal changes in thyroid and parathyroid physiology during pregnancy 2)  Describe the impact of thyroid and parathyroid dysregulation on maternal and fetal health 3)  Compare and contrast management of thyroid and parathyroid disorders during pregnancy vs. non-pregnancy   4)  Recognize the importance of multidisciplinary care of patients with thyroid and parathyroid disorders References: 1. Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, Sullivan S. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017 Mar;27(3):315-389. doi: 10.1089/thy.2016.0457. Erratum in: Thyroid. 2017 Sep;27(9):1212. doi: 10.1089/thy.2016.0457.correx. PMID: 28056690 https://pubmed.ncbi.nlm.nih.gov/28056690/ 2. Jee SB, Sawal A. Physiological Changes in Pregnant Women Due to Hormonal Changes. Cureus. 2024 Mar 5;16(3):e55544. doi: 10.7759/cureus.55544. PMID: 38576690; PMCID: PMC10993087 https://pubmed.ncbi.nlm.nih.gov/38576690/ 3. Patel, Kepal N. MD; Yip, Linwah MD; Lubitz, Carrie C. MD, MPH; Grubbs, Elizabeth G. MD; Miller, Barbra S. MD; Shen, Wen MD; Angelos, Peter MD; Chen, Herbert MD; Doherty, Gerard M. MD; Fahey, Thomas J. III MD; Kebebew, Electron MD; Livolsi, Virginia A. MD; Perrier, Nancy D. MD; Sipos, Jennifer A. MD; Sosa, Julie A. MD; Steward, David MD; Tufano, Ralph P. MD; McHenry, Christopher R. MD; Carty, Sally E. MD. The American Association of Endocrine Surgeons Guidelines for the Definitive Surgical Management of Thyroid Disease in Adults. Annals of Surgery 271(3):p e21-e93, March 2020.  DOI: 10.1097/SLA.0000000000003580 https://pubmed.ncbi.nlm.nih.gov/32079830/ 4. Appelman-Dijkstra NM, Pilz S. Approach to the Patient: Management of Parathyroid Diseases Across Pregnancy. J Clin Endocrinol Metab. 2023 May 17;108(6):1505-1513. doi: 10.1210/clinem/dgac734. PMID: 36546344; PMCID: PMC10188304 https://pubmed.ncbi.nlm.nih.gov/36546344/  5. Eremkina A, Bibik E,  Mirnaya S, Krupinova J, Gorbacheva A, Dobreva E, Mokrysheva N. Different treatment strategies in primary hyperparathyroidism during pregnancy.  Endocrine. 2022 Sep;77(3):556-560. doi: 10.1007/s12020-022-03127-3. Epub 2022 Jul 12. PMID: 35821184 https://pubmed.ncbi.nlm.nih.gov/35821184/ TRUELEARN LINK: https://truelearn.referralrock.com/l/BTKPODCAST/ Discount code: BTKPODCAST Using the discount code, you can get a discount of $25 off our Residency (General surgery, anesthesiology, OBGYN, Psychiatry, Peds, Neurology, Emergency Medicine, Internal Medicine, and Family Medicine), USMLE, andCOMLEX SmartBank subscriptions of 90-days or more. The code can also be applied for 15% off our allied healthSmartBanks (PA, Nurse Practitioner, Pharmacy, PT, OT, etc.). Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

Did you know that one simple change in your kitchen could transform your health? In today's episode, Miles Hassell, MD, explores the extensive health benefits of extra virgin olive oil (EVOO). Drawing on three lines of evidence, he makes a compelling case for making EVOO your primary kitchen fat. A few takeaways from Miles Hassell, MD: Studies have shown that EVOO supports gut health. A healthy gut can contribute to improved digestion, a stronger immune system, and even better mental health. Regular consumption of EVOO has been associated with a lower incidence of dementia. This connection underscores the importance of incorporating EVOO into your diet as part of a proactive approach to brain health. Research indicates that higher consumption of olive oil is linked to a lower incidence of certain cancers. The powerful antioxidant and anti-inflammatory properties of EVOO play a significant role in reducing cancer risk. One of the most well-documented benefits of EVOO is its ability to lower the risk of heart disease. Unlike other vegetable oils, EVOO has been consistently shown to promote cardiovascular health.   Miles Hassell, MD emphasizes that EVOO is not just a cooking ingredient but a therapeutic tool. Its unique composition of monounsaturated fats, antioxidants, and anti-inflammatory compounds makes it a powerhouse for health promotion.  While other vegetable oils lack the same level of evidence for health benefits, EVOO stands out for its protective effects. When compared to other oils, EVOO consistently comes out on top.  Making the switch to EVOO can be a simple yet powerful change to improve your overall health. So next time you're cooking, reach for the EVOO and enjoy both its flavor and its multitude of health benefits.   Join the cause! Support the podcast and be a champion of a future episode by donating here: https://greatmed.org/donate/ For more information and references head to: https://greatmed.org   Purchase Good Food Great Medicine    Twitter (X): https://x.com/greatmedorg Instagram: @mileshassellmd Facebook: https://www.facebook.com/people/GreatMedorg/61554645308577/ Substack: https://substack.com/@greatmed YouTube: https://www.youtube.com/@greatmedicine email: info@greatmed.org   References for Today's Episode: Markellos C, Ourailidou ME, Gavriatopoulou M, Halvatsiotis P, Sergentanis TN, Psaltopoulou T. Olive oil intake and cancer risk: A systematic review and meta-analysis. PLoS One. 2022 Jan 11;17(1):e0261649. doi: 10.1371/journal.pone.0261649. PMID: 35015763; PMCID: PMC8751986. Millman JF, Okamoto S, Teruya T, Uema T, Ikematsu S, Shimabukuro M, Masuzaki H. Extra-virgin olive oil and the gut-brain axis: influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health. Nutr Rev. 2021 Nov 10;79(12):1362-1374. doi: 10.1093/nutrit/nuaa148. PMID: 33576418; PMCID: PMC8581649. Guasch-Ferré M, Hruby A, Salas-Salvadó J, Martínez-González MA, Sun Q, Willett WC, Hu FB. Olive oil consumption and risk of type 2 diabetes in US women. Am J Clin Nutr. 2015 Aug;102(2):479-86. doi: 10.3945/ajcn.115.112029. Epub 2015 Jul 8. PMID: 26156740; PMCID: PMC4515873 Valls-Pedret C, Lamuela-Raventós RM, Medina-Remón A, Quintana M, Corella D, Pintó X, Martínez-González MÁ, Estruch R, Ros E. Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk. J Alzheimers Dis. 2012;29(4):773-82. doi: 10.3233/JAD-2012-111799. PMID: 22349682. Moreno-Luna R, Muñoz-Hernandez R, Miranda ML, Costa AF, Jimenez-Jimenez L, Vallejo-Vaz AJ, Muriana FJ, Villar J, Stiefel P. Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am J Hypertens. 2012 Dec;25(12):1299-304. doi: 10.1038/ajh.2012.128. Epub 2012 Aug 23. PMID: 22914255. Cougnard-Grégoire A, Merle BM, Korobelnik JF, Rougier MB, Delyfer MN, Le Goff M, Samieri C, Dartigues JF, Delcourt C. Olive Oil Consumption and Age-Related Macular Degeneration: The Alienor Study. PLoS One. 2016 Jul 28;11(7):e0160240. doi: 10.1371/journal.pone.0160240. PMID: 27467382; PMCID: PMC4965131. Kien CL, Bunn JY, Tompkins CL, Dumas JA, Crain KI, Ebenstein DB, Koves TR, Muoio DM. Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood. Am J Clin Nutr. 2013 Apr;97(4):689-97. doi: 10.3945/ajcn.112.051730. Epub 2013 Feb 27. Erratum in: Am J Clin Nutr. 2013 Aug;98(2):511. PMID: 23446891; PMCID: PMC3607650. Guasch-Ferré M, Liu G, Li Y, Sampson L, Manson JE, Salas-Salvadó J, Martínez-González MA, Stampfer MJ, Willett WC, Sun Q, Hu FB. Olive Oil Consumption and Cardiovascular Risk in U.S. Adults. J Am Coll Cardiol. 2020 Apr 21;75(15):1729-1739. doi: 10.1016/j.jacc.2020.02.036. Epub 2020 Mar 5. PMID: 32147453; PMCID: PMC7233327. Ferrara LA, Raimondi AS, d'Episcopo L, Guida L, Dello Russo A, Marotta T. Olive oil and reduced need for antihypertensive medications. Arch Intern Med. 2000 Mar 27;160(6):837-42. doi: 10.1001/archinte.160.6.837. PMID: 10737284. Priore P, Cavallo A, Gnoni A, Damiano F, Gnoni GV, Siculella L. Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease. IUBMB Life. 2015 Jan;67(1):9-17. doi: 10.1002/iub.1340. Epub 2015 Jan 28. PMID: 25631376. Gutiérrez-Repiso C, Soriguer F, Rojo-Martínez G, García-Fuentes E, Valdés S, Goday A, Calle-Pascual A, López-Alba A, Castell C, Menéndez E, Bordiú E, Delgado E, Ortega E, Pascual-Manich G, Urrutia I, Mora-Peces I, Vendrell J, Vázquez JA, Franch J, Girbés J, Castaño L, Serrano-Ríos M, Martínez-Larrad MT, Catalá M, Carmena R, Gomis R, Casamitjana R, Gaztambide S. Variable patterns of obesity and cardiometabolic phenotypes and their association with lifestyle factors in the Di@bet.es study. Nutr Metab Cardiovasc Dis. 2014 Sep;24(9):947-55. doi: 10.1016/j.numecd.2014.04.019. Epub 2014 Jun 9. PMID: 24984822. Ramsden CE, Zamora D, Leelarthaepin B, Majchrzak-Hong SF, Faurot KR, Suchindran CM, Ringel A, Davis JM, Hibbeln JR. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ. 2013 Feb 4;346:e8707. doi: 10.1136/bmj.e8707. Erratum in: BMJ. 2013;346:f903. PMID: 23386268; PMCID: Juul F, Vaidean G, Lin Y, Deierlein AL, Parekh N. Ultra-Processed Foods and Incident Cardiovascular Disease in the Framingham Offspring Study. J Am Coll Cardiol. 2021 Mar 30;77(12):1520-1531. doi: 10.1016/j.jacc.2021.01.047. PMID: 33766258. Schnabel L, Kesse-Guyot E, Allès B, Touvier M, Srour B, Hercberg S, Buscail C, Julia C. Association Between Ultraprocessed Food Consumption and Risk of Mortality Among Middle-aged Adults in France. JAMA Intern Med. 2019 Apr 1;179(4):490-498. doi: 10.1001/jamainternmed.2018.7289. PMID: 30742202; PMCID: PMC6450295. ​​Lane MM, Gamage E, Du S, Ashtree DN, McGuinness AJ, Gauci S, Baker P, Lawrence M, Rebholz CM, Srour B, Touvier M, Jacka FN, O'Neil A, Segasby T, Marx W. Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses. BMJ. 2024 Feb 28;384:e077310. doi: 10.1136/bmj-2023-077310. PMID: 38418082; PMCID: PMC10899807. Alonso-Pedrero L, Ojeda-Rodríguez A, Martínez-González MA, Zalba G, Bes-Rastrollo M, Marti A. Ultra-processed food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project. Am J Clin Nutr. 2020 Jun 1;111(6):1259-1266. doi: 10.1093/ajcn/nqaa075. PMID: 32330232. Taneri PE, Wehrli F, Roa-Díaz ZM, Itodo OA, Salvador D, Raeisi-Dehkordi H, Bally L, Minder B, Kiefte-de Jong JC, Laine JE, Bano A, Glisic M, Muka T. Association Between Ultra-Processed Food Intake and All-Cause Mortality: A Systematic Review and Meta-Analysis. Am J Epidemiol. 2022 Jun 27;191(7):1323-1335. doi: 10.1093/aje/kwac039. PMID: 35231930.    

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: July 18, 2017 All you need to know about CNS Lyme disease in 10 minutes or less. More to come in a few weeks when Dr. Colin Quinn shares his experience with what was "definitely not Lyme disease." Stay tuned. Produced by James E Siegler. Music by Josh Woodward, Chris Zabriskie, Peter Rudenko, Advent Chamber Orchestra. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. REFERENCESHalperin JJ, Shapiro ED, Logigian E, et al. Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2007;69(1):91-102. Erratum in: Neurology 2008;70(14):1223. PMID 17522387Marques A. Chronic Lyme disease: a review. Infect Dis Clin North Am 2008;22(2):341-60, vii-viii. PMID 18452806Marques AR. Lyme neuroborreliosis. Continuum (Minneap Minn) 2015;21(6 Neuroinfectious Disease):1729-44. PMID 26633786 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

Neste episódio falaremos do aminoácido Glicina. Este audio é uma aula rápida e prática do nosso curso BrainBoost, mais de 50 suplementos para seu cérebro. ENTRAR LOGO NESTA BAGAÇA: https://drdupr.at/bb O que esperar deste episódio? O que é a glicina? Onde encontramos ? Pq suplementar? Como pode impactar nosso sono ? Artigos Dicas práticas referências: (Kawai N, 2015)     Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701. doi: 10.1155/2017/1716701. Epub 2017 Mar 1. Erratum in: Oxid Med Cell Longev. 2022 Feb 23;2022:9857645. doi: 10.1155/2022/9857645. PMID: 28337245; PMCID: PMC5350494.   McCarty MF, O'Keefe JH, DiNicolantonio JJ. Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection. Ochsner J. 2018 Spring;18(1):81-87. PMID: 29559876; PMCID: PMC5855430.   Zafra F, Aragón C, Olivares L, Danbolt NC, Giménez C, Storm-Mathisen J. Glycine transporters are differentially expressed among CNS cells. J Neurosci. 1995 May;15(5 Pt 2):3952-69. doi: 10.1523/JNEUROSCI.15-05-03952.1995. PMID: 7751957; PMCID: PMC6578198.   Kawai N, Sakai N, Okuro M, Karakawa S, Tsuneyoshi Y, Kawasaki N, Takeda T, Bannai M, Nishino S. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015 May;40(6):1405-16. doi: 10.1038/npp.2014.326. Epub 2014 Dec 23. PMID: 25533534; PMCID: PMC4397399.   Yamadera W, Inagawa K, Chiba S, Bannai M, Takahashi M, Nakayama K. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep Biol Rhythms. 2007;5:126–131.   Inagawa K, Hiraoka T, Kohda T, Yamadera W, Takahashi M. Subjective effects of glycine ingestion before bedtime on sleep quality. Sleep Biol Rhythms. 2006;4:75–77.    Cruz M, Maldonado-Bernal C, Mondragón-Gonzalez R, Sanchez-Barrera R, Wacher NH, Carvajal-Sandoval G, Kumate J. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes. J Endocrinol Invest. 2008 Aug;31(8):694-9. doi: 10.1007/BF03346417. PMID: 18852529.     Müller P, Dammann HG, Bergdolt H, Simon B. Einfluss von Glycin auf die gastroduodenale Verträglichkeit von Acetylsalicylsäure. Eine endoskopisch kontrollierte Doppelblindstudie an gesunden Probanden [The effect of glycine on the gastroduodenal tolerability of acetylsalicylic acid. An endoscopic, controlled double-blind study in healthy subjects]. Arzneimittelforschung. 1991 Aug;41(8):812-4. German. PMID: 1781803.   Meléndez-Hevia E, De Paz-Lugo P, Cornish-Bowden A, Cárdenas ML. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. J Biosci. 2009 Dec;34(6):853-72. doi: 10.1007/s12038-009-0100-9. PMID: 20093739.

Auto-immune diseases can be incredibly challenging to manage, but there are numerous lifestyle interventions that can positively influence your health. By focusing on key areas such as waistline, sunlight, sleep, and heat, and using various modalities, you can take significant steps toward improving your well-being.  In today's episode Miles Hassel, MD explores various tools that can favorably alter the course of your auto-immune disease: Maintaining a healthy waistline through balanced nutrition and regular exercise is essential. Exposure to sunlight helps your body produce Vitamin D, a crucial nutrient for immune function. Aim to spend at least 15-20 minutes in the sun each day, especially in the morning.  Sleep deprivation has a direct impact on illness. Adequate sleep supports immune function, reduces inflammation, and helps your body repair itself. Heat therapy can be an effective tool for managing auto-immune symptoms. Tailor your exercise routine to match your energy levels and physical capabilities, ensuring consistency over intensity. Diet plays a pivotal role in managing auto-immune diseases. Focus on anti-inflammatory foods such as leafy greens, fatty fish, nuts, and seeds.   Lifestyle interventions require rigorous approaches with consistency. These changes are not quick fixes; they take time to show results. Be patient with yourself and understand that turning your health around is a gradual process. By embracing these lifestyle interventions and utilizing different modalities, you can significantly reduce the burden of your auto-immune disease.  Join the cause! Support the podcast and be a champion of a future episode by donating here: https://greatmed.org/donate/   For more information and references head to: https://greatmed.org/cold-flu/have-fewer-sick-days/   Purchase Good Food Great Medicine  Twitter (X): https://x.com/greatmedorg Instagram: @mileshassellmd Facebook: https://www.facebook.com/people/GreatMedorg/61554645308577/ Substack: https://substack.com/@greatmed YouTube: https://www.youtube.com/@greatmedicine email: info@greatmed.org   References for today's episode: Lindqvist PG, et al. Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the Melanoma in Southern Sweden cohort. J Intern Med. 2016 Oct;280(4):375-87. doi: 10.1111/joim.12496. Epub 2016 Mar 16. https://pubmed.ncbi.nlm.nih.gov/26992108/ -Alfredsson L, Armstrong BK, Butterfield DA, Chowdhury R, de Gruijl FR, Feelisch M, Garland CF, Hart PH, Hoel DG, Jacobsen R, Lindqvist PG, Llewellyn DJ, Tiemeier H, Weller RB, Young AR. Insufficient Sun Exposure Has Become a Real Public Health Problem. Int J Environ Res Public Health. 2020 Jul 13;17(14):5014. doi: 10.3390/ijerph17145014. https://pubmed.ncbi.nlm.nih.gov/32668607/ -Patrick RP, et al. Sauna use as a lifestyle practice to extend healthspan. Exp Gerontol. 2021 Oct 15;154:111509. doi: 10.1016/j.exger.2021.111509. Epub 2021 Aug 5. https://pubmed.ncbi.nlm.nih.gov/34363927/ -Ostkamp P, et al. Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2018457118. doi: 10.1073/pnas.2018457118. Erratum in: Proc Natl Acad Sci U S A. 2021 Jul 20;118(29): https://pubmed.ncbi.nlm.nih.gov/33376202/ -Tsigalou C, et al. Autoantibody Production in Obesity: Is There Evidence for a Link Between Obesity and Autoimmunity? Curr Obes Rep. 2020 Sep;9(3):245-254. doi: 10.1007/s13679-020-00397-8. https://pubmed.ncbi.nlm.nih.gov/32632847/ -Garbarino S, Lanteri P, Bragazzi NL, Magnavita N, Scoditti E. Role of sleep deprivation in immune-related disease risk and outcomes. Commun Biol. 2021 Nov 18;4(1):1304. doi: 10.1038/s42003-021-02825-4. https://pubmed.ncbi.nlm.nih.gov/34795404/

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: November 13, 2017 How often do you call the plumber and say, "My faucet is leaking," and then the plumber REMOVES your faucet? Problem solved, right? Ironically, this simplistic approach works extremely well in a variety of epileptic conditions. In this week's show, Dr. Myriam Abdennadher and Danielle Becker comment on the protocol and efficacy for surgery in patients with drug-resistant epilepsy. Produced by James E. Siegler. Music by Little Glass Men, Montplaisir, Three Chain Links, and Squire Tuck. Voiceover by Isa Smrstik. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. REFERENCESDeGiorgio CM, Krahl SE. Neurostimulation for drug-resistant epilepsy. Continuum (Minneap Minn) 2013;19(3 Epilepsy):743-55. PMID 23739108Engel J Jr, Wiebe S, French J, et al. Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neurological Surgeons. Neurology 2003;60(4):538-47. Erratum in: Neurology 2003;60(8):1396. PMID 12601090Englot DJ, Wang DD, Rolston JD, Shih TT, Chang EF. Rates and predictors of long-term seizure freedom after frontal lobe epilepsy surgery: a systematic review and meta-analysis. J Neurosurg 2012;116(5):1042-8. PMID 22304450Jobst BC, Cascino GD. Resective epilepsy surgery for drug-resistant focal epilepsy: a review. JAMA 2015;313(3):285-93. PMID 25602999Schwartz TH, Spencer DD. Strategies for reoperation after comprehensive epilepsy surgery. J Neurosurg 2001;95(4):615-23. PMID 11596956Spencer S, Huh L. Outcomes of epilepsy surgery in adults and children. Lancet Neurol 2008;7(6):525-37. PMID 18485316 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

What are the outcomes in patients who suffer in-hospital cardiac arrest based on the duration of the code? This podcast episode covers a retrospective cohort study that analyzed this. The Vasopressor & Inotrope Handbook I have written "The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals," a must-read for anyone caring for critically ill patients (check out the reviews)! You have several options to get a physical copy while supporting my endeavors. If you're in the US, you can order A SIGNED & PERSONALIZED COPY for $29.99 or via AMAZON (for orders outside the US). Ebook versions: AMAZON KINDLE for $9.99. APPLE BOOKS and GOOGLE PLAY. ¡Excelentes noticias! Mi libro ha sido traducido al español y las versiones electrónicas están disponibles para su compra for solo $9.99 en AMAZON KINDLE, APPLE BOOKS y GOOGLE PLAY.When you use these affiliate links, I earn an additional commission at no extra cost to you, which is a great way to support my work. Citation: Okubo M, Komukai S, Andersen LW, Berg RA, Kurz MC, Morrison LJ, Callaway CW; American Heart Association's Get With The Guidelines—Resuscitation Investigators. Duration of cardiopulmonary resuscitation and outcomes for adults with in-hospital cardiac arrest: retrospective cohort study. BMJ. 2024 Feb 7;384:e076019. doi: 10.1136/bmj-2023-076019. Erratum in: BMJ. 2024 Apr 18;385:q900. PMID: 38325874; PMCID: PMC10847985. --- Support this podcast: https://podcasters.spotify.com/pod/show/eddyjoemd/support

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021.Originally released: December 26, 20192019 was a big year. The year of the Mueller report. The American college admissions scandals. Brexit. But it was also the year the US Women's team won the World Cup and lobbied for the equal pay of women and men in sports. It was the year of NMO, in which several pivotal trials showed the benefit of disease-modulating therapy in this condition. The year Will Smith played Genie in Aladdin.2019 was a great year. And as we wrap up 2019, this week's episode includes some of the highlights. Enjoy!Produced by James E Siegler with support from Erika Mejia, Rajat Dhar, and the entire Siegler family. Music courtesy of Axletree, Chris Zabriskie, John Paston, Kevin Mcleod, Josh Woodward, Steve Combs, Lee Rosevere, Scott Holmes, Advent Chamber Orchestra, Coldnoise, and Pachyderm. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast.REFERENCES[BRAIN FOOD]Devore EE, Kang JH, Breteler MM, Grodstein F. Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol 2012;72(1):135-43. PMID 22535616Kennedy DO, Wightman EL, Reay JL, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 2010;91(6):1590-7. PMID 20357044Lefèvre-Arbogast S, Gaudout D, Bensalem J, et al. Pattern of polyphenol intake and the long-term risk of dementia in older persons. Neurology 2018;90(22):e1979-e1988. PMID 29703769Liu QP, Wu YF, Cheng HY, et al. Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and meta-analysis of prospective cohort studies. Nutrition 2016;32(6):628-36. PMID 26944757Miller MG, Hamilton DA, Joseph JA, Shukitt-Hale B. Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. Eur J Nutr 2018;57(3):1169-80. PMID 28283823Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement 2015;11(9):1015-22. PMID 26086182Newman JC, Covarrubias AJ, Zhao M, et al. Ketogenic diet reduces midlife mortality and improves memory in aging mice. Cell Metab 2017;26(3):547-57.e8. PMID 28877458Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol 2014;13(8):788-94. Erratum in: Lancet Neurol 2014;13(11):1070. PMID 25030513Okkersen K, Jimenez-Moreno C, Wenninger S, et al. Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial. Lancet Neurol 2018;17(8):671-80. PMID 29934199Radd-Vagenas S, Duffy SL, Naismith SL,

Rapha, Ênio e Guilherme Kenzzo conversam sobre Transtorno de Ansiedade Generalizada (TAG): - Quais são os diagnósticos diferenciais? - Como diagnosticar e acompanhar TAG? - Como tratar TAG? Tudo isso nesse episódio! Referências: 1. Szuhany KL, Simon NM. Anxiety Disorders: A Review. JAMA. 2022 Dec 27;328(24):2431-2445. doi: 10.1001/jama.2022.22744. PMID: 36573969. 2. Penninx BW, Pine DS, Holmes EA, Reif A. Anxiety disorders. Lancet. 2021 Mar 6;397(10277):914-927. doi: 10.1016/S0140-6736(21)00359-7. Epub 2021 Feb 11. Erratum in: Lancet. 2021 Mar 6;397(10277):880. PMID: 33581801; PMCID: PMC9248771. 3. Stein MB, Sareen J. CLINICAL PRACTICE. Generalized Anxiety Disorder. N Engl J Med. 2015 Nov 19;373(21):2059-68. doi: 10.1056/NEJMcp1502514. PMID: 26580998. 4. Stahl, S. M. (2021). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (5th ed.). Cambridge University Press. - Jeremy DeMartini, Gayatri Patel, Tonya L Fancher. Generalized Anxiety Disorder. Ann Intern Med. 2019 Apr 2;170(7):ITC49-ITC64. doi: 10.7326/AITC201904020. 5. American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (5th ed., text rev.) 6. Slee, April et al. “Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis.” Lancet (London, England) vol. 393,10173 (2019): 768-777. doi:10.1016/S0140-6736(18)31793-8 7. Brawman-Mintzer, Olga et al. “Sertraline treatment for generalized anxiety disorder: a randomized, double-blind, placebo-controlled study.” The Journal of clinical psychiatry vol. 67,6 (2006): 874-81. doi:10.4088/jcp.v67n0603 8. Guaiana, Giuseppe et al. “Hydroxyzine for generalised anxiety disorder.” The Cochrane database of systematic reviews ,12 CD006815. 8 Dec. 2010, doi:10.1002/14651858.CD006815.pub2

In this second of a two part podcast special Iain and Simon go through twenty of the top papers from the last year or so, as presented by Simon at the Big Sick Conference in Zermatt earlier this year. All the details and more discussion can be found on the blog site. In Part 2 they discuss papers about major haemorrhage, trauma, cardiac arrest and more.  In Part 1 they discuss all things airway, including where we should be intubating patients needing immediate haemorrhage control. VL vs DL, the effect of blade size on intubation success, whether small adult ventilation bags are better than larger versions, intubating comatose poisoned patients, and more.  Papers Jansen JO et al. Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial. JAMA. 2023 Nov 21;330(19):1862-1871. doi: 10.1001/jama.2023.20850. PMID: 37824132; PMCID: PMC10570916. Davenport R et al. Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial. JAMA. 2023 Nov 21;330(19):1882-1891. doi: 10.1001/jama.2023.21019. PMID: 37824155; PMCID: PMC10570921. PATCH-Trauma Investigators and the ANZICS Clinical Trials Group; Prehospital Tranexamic Acid for Severe Trauma. N Engl J Med. 2023 Jul 13;389(2):127-136. doi: 10.1056/NEJMoa2215457. Epub 2023 Jun 14. PMID: 37314244. Shepherd JM et al Safety and efficacy of artesunate treatment in severely injured patients with traumatic hemorrhage. The TOP-ART randomized clinical trial. Intensive Care Med. 2023 Aug;49(8):922-933. doi: 10.1007/s00134-023-07135-3. Epub 2023 Jul 20. PMID: 37470832; PMCID: PMC10425486. Bouzat P et al. Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial. JAMA. 2023 Apr 25;329(16):1367-1375. doi: 10.1001/jama.2023.4080. PMID: 36942533; PMCID: PMC10031505. Torres CM, Kent A, Scantling D, Joseph B, Haut ER, Sakran JV. Association of Whole Blood With Survival Among Patients Presenting With Severe Hemorrhage in US and Canadian Adult Civilian Trauma Centers. JAMA Surg. 2023 May 1;158(5):532-540. doi: 10.1001/jamasurg.2022.6978. Erratum in: JAMA Surg. 2023 Apr 5;: PMID: 36652255; PMCID: PMC9857728. Marsden MER, Kellett S, Bagga R, Wohlgemut JM, Lyon RL, Perkins ZB, Gillies K, Tai NR. Understanding pre-hospital blood transfusion decision-making for injured patients: an interview study. Emerg Med J. 2023 Nov;40(11):777-784. doi: 10.1136/emermed-2023-213086. Epub 2023 Sep 13. PMID: 37704359; PMCID: PMC10646861. Wohlgemut JM, Pisirir E, Stoner RS, Kyrimi E, Christian M, Hurst T, Marsh W, Perkins ZB, Tai NRM. Identification of major hemorrhage in trauma patients in the prehospital setting: diagnostic accuracy and impact on outcome. Trauma Surg Acute Care Open. 2024 Jan 12;9(1):e001214. doi: 10.1136/tsaco-2023-001214. PMID: 38274019; PMCID: PMC10806521. Cheskes S, Verbeek PR, Drennan IR, McLeod SL, Turner L, Pinto R, Feldman M, Davis M, Vaillancourt C, Morrison LJ, Dorian P, Scales DC. Defibrillation Strategies for Refractory Ventricular Fibrillation. N Engl J Med. 2022 Nov 24;387(21):1947-1956. doi: 10.1056/NEJMoa2207304. Epub 2022 Nov 6. PMID: 36342151. Siddiqua N, Mathew R, Sahu AK, Jamshed N, Bhaskararayuni J, Aggarwal P, Kumar A, Khan MA. High-dose versus low-dose intravenous nitroglycerine for sympathetic crashing acute pulmonary edema: a randomised controlled trial. Emerg Med J. 2024 Jan 22;41(2):96-102. doi: 10.1136/emermed-2023-213285. PMID: 38050078. Wilkinson-Stokes M, Betson J, Sawyer S. Adverse events from nitrate administration during right ventricular myocardial infarction: a systematic review and meta-analysis. Emerg Med J. 2023 Feb;40(2):108-113. doi: 10.1136/emermed-2021-212294. Epub 2022 Sep 30. PMID: 36180168. Patterson T, Perkins GD, Perkins A, Clayton T, Evans R, Dodd M, Robertson S, Wilson K, Mellett-Smith A, Fothergill RT, McCrone P, Dalby M, MacCarthy P, Firoozi S, Malik I, Rakhit R, Jain A, Nolan JP, Redwood SR; ARREST trial collaborators. Expedited transfer to a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest (ARREST): a UK prospective, multicentre, parallel, randomised clinical trial. Lancet. 2023 Oct 14;402(10410):1329-1337. doi: 10.1016/S0140-6736(23)01351-X. Epub 2023 Aug 27. PMID: 37647928. Issa EC, Ware PJ, Bitange P, Cooper GJ, Galea T, Bengiamin DI, Young TP. The “Syringe Hickey”: An Alternative Skin Marking Method for Lumbar Puncture. J Emerg Med. 2023 Mar;64(3):400-404. doi: 10.1016/j.jemermed.2023.01.013. PMID: 37019501.

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities. Episodes originally aired from 2016 to 2021. Originally released: May 16, 2019 It would be an understatement to say that endovascular thrombectomy has revolutionized acute stroke management. As of 2018, the American Heart Association recommends treatment up to 24 hours after time last seen normal for select patients. This week on the BrainWaves podcast, Dr. Tudor Jovin--PI for the DAWN and REVASCAT clinical trials--summarizes the history of thrombectomy trials and what it is about our current strategies that have breathed new life into a technique that has historically fizzled. Produced by James E Siegler and Jesse Thon. Music courtesy of Cuicuitte, Coldnoise, Medyn, Jon Watts, Lee Rosevere, and Mystery Mammal. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. Be sure to follow us on Twitter (now X) @brainwavesaudio for the latest updates to the podcast. REFERENCES Campbell BC, Majoie CB, Albers GW, et al. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data. Lancet Neurol 2019;18(1):46-55. Erratum in: Lancet Neurol 2019 Mar;18(3):e2. PMID 30413385Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 2016;387(10029):1723-31. PMID 26898852Gross BA, Jadhav AP, Jankowitz BT, Jovin TG. The ongoing revolution in thrombectomy: expanding inclusion criteria to larger cores. World Neurosurg 2018;120:393-94. PMID 30292027Heit JJ, Wintermark M. Perfusion computed tomography for the evaluation of acute ischemic stroke: strengths and pitfalls. Stroke 2016;47(4):1153-8. PMID 26965849Jadhav AP, Molyneaux BJ, Hill MD, Jovin TG. Care of the post-thrombectomy patient. Stroke 2018;49(11):2801-07. PMID 30355218Konstas AA, Goldmakher GV, Lee TY, Lev MH. Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations. AJNR Am J Neuroradiol 2009;30(5):885-92. PMID 19299489Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med 2018;378(1):11-21. PMID 29129157Román LS, Menon BK, Blasco J, et al. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data. Lancet Neurol 2018;17(10):895-904. PMID 30264728 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

I read from erotic to erratum.     The DSM-5 has "erotomania" as a symptom of "delusional disorder"  https://psychcentral.com/disorders/erotomania-delusions-of-love https://en.wikipedia.org/wiki/Erotomania     The word of the episode is "erratic".     Theme music from Jonah Kraut https://jonahkraut.bandcamp.com/     Merchandising! https://www.teepublic.com/user/spejampar     "The Dictionary - Letter A" on YouTube   "The Dictionary - Letter B" on YouTube   "The Dictionary - Letter C" on YouTube   "The Dictionary - Letter D" on YouTube   "The Dictionary - Letter E" on YouTube     Featured in a Top 10 Dictionary Podcasts list! https://blog.feedspot.com/dictionary_podcasts/     Backwards Talking on YouTube: https://www.youtube.com/playlist?list=PLmIujMwEDbgZUexyR90jaTEEVmAYcCzuq     https://linktr.ee/spejampar dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://www.threads.net/@dictionarypod https://twitter.com/dictionarypod https://www.instagram.com/dictionarypod/ https://www.patreon.com/spejampar https://www.tiktok.com/@spejampar 917-727-5757

The JournalFeed podcast for the week of Feb 26 – March 1, 2024.These are summaries from just 2 of the 5 article we cover every week! For access to more, please visit JournalFeed.org for details about becoming a member.Monday Spoon Feed:This systematic review and meta-analysis concluded, with moderate certainty evidence, that oseltamivir has little to no effect on hospitalization but does increase nausea and vomiting. Source:Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza. JAMA Intern Med. 2024 Jan 1;184(1):18-27. doi: 10.1001/jamainternmed.2023.0699. Erratum in: JAMA Intern Med. 2023 Nov 20;: PMID: 37306992; PMCID: PMC10262060.Tuesday Spoon FeedThis survey of US physicians found taking more than 3 weeks of vacation per year was associated with lower rates of burnout, while spending 30 minutes or more per vacation day on patient-related work was associated with increased burnout. Source:Vacation Days Taken, Work During Vacation, and Burnout Among US Physicians. JAMA Netw Open. 2024 Jan 2;7(1):e2351635. doi: 10.1001/jamanetworkopen.2023.51635.

Eve Benhamou's book Contemporary Disney Animation: Genre, Gender and Hollywood (Edinburgh UP, 2022) is the first in-depth study of Disney's latest animated output from the perspective of genre theory. Analysing a decade in Disney's history (2008-2018), Benhamou examines the multifaceted interactions between animated films, Disney properties such as Pixar and Marvel, and popular genres including the romantic comedy, the superhero film and the cop buddy film. Through this extensive critical lens, combined with a focus on gender, she provides illuminating and original insights on films such as Tangled, Frozen and Moana. Informed by wider discourses on contemporary Hollywood and post-feminism, this book challenges conventional approaches to Disney, and foregrounds the importance of animation in understandings of film genres. Erratum. In the interview, Eve said that Eeyore was from Dumbo, while it is from Winnie the Pooh. She also said "the first Ralph Breaks the Internet", which is of course just Wreck-It Ralph.  Peter C. Kunze is an assistant professor of communication at Tulane University. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Eve Benhamou's book Contemporary Disney Animation: Genre, Gender and Hollywood (Edinburgh UP, 2022) is the first in-depth study of Disney's latest animated output from the perspective of genre theory. Analysing a decade in Disney's history (2008-2018), Benhamou examines the multifaceted interactions between animated films, Disney properties such as Pixar and Marvel, and popular genres including the romantic comedy, the superhero film and the cop buddy film. Through this extensive critical lens, combined with a focus on gender, she provides illuminating and original insights on films such as Tangled, Frozen and Moana. Informed by wider discourses on contemporary Hollywood and post-feminism, this book challenges conventional approaches to Disney, and foregrounds the importance of animation in understandings of film genres. Erratum. In the interview, Eve said that Eeyore was from Dumbo, while it is from Winnie the Pooh. She also said "the first Ralph Breaks the Internet", which is of course just Wreck-It Ralph.  Peter C. Kunze is an assistant professor of communication at Tulane University. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/gender-studies

Eve Benhamou's book Contemporary Disney Animation: Genre, Gender and Hollywood (Edinburgh UP, 2022) is the first in-depth study of Disney's latest animated output from the perspective of genre theory. Analysing a decade in Disney's history (2008-2018), Benhamou examines the multifaceted interactions between animated films, Disney properties such as Pixar and Marvel, and popular genres including the romantic comedy, the superhero film and the cop buddy film. Through this extensive critical lens, combined with a focus on gender, she provides illuminating and original insights on films such as Tangled, Frozen and Moana. Informed by wider discourses on contemporary Hollywood and post-feminism, this book challenges conventional approaches to Disney, and foregrounds the importance of animation in understandings of film genres. Erratum. In the interview, Eve said that Eeyore was from Dumbo, while it is from Winnie the Pooh. She also said "the first Ralph Breaks the Internet", which is of course just Wreck-It Ralph.  Peter C. Kunze is an assistant professor of communication at Tulane University. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/film

Join Sheila and special guest this week Emily Knell Spaeth, PT, DPT, IBCLC, LMT, NTMTC, CNT, RPYT as they cover all things related to the NICU. Dr. Emily Spaeth is an expert in all things pregnancy, birth, postpartum, and babies. She is the founder and CEO of Be Well Baby PDX. While supporting families as a doctor of physical therapy in the neonatal ICU, Emily saw a deep societal need for a more holistic approach to peripartum care, and decided to blend her background in yoga, massage, and lactation support with her expertise in physical therapy to create a full spectrum peripartum experience for her clients.  Emily offers a range of continuing education courses for professionals on the Lactation OT platform.  Additionally, her website offers an array of courses covering topics that help parents understand their baby's cues, infant massage techniques, newborn care essentials, and more.  Courses: www.bewellbabypdx.com/courses FREE GUIDE- Respectful Tummy Time for the Newborn:  www.bewellbabypdx.com/subscribe Follow her on Instagram and Facebook and Linked In @bewellbabypdx Affiliate Codes: ------------------------------------------ Medbridge Affiliate website: https://www.medbridgeeducation.com/pushing-pediatrics Medbridge Affiliate Code: PUSHINGPEDS ----------------------------------------- Resources: Palisano, R. J., Orlin, M. N., & Schreiber, R. (2023). Campbell's physical therapy for children. Elsevier. https://pediatricapta.org/fact-sheets/ Sweeney JK, Heriza CB, Blanchard Y; American Physical Therapy Association. Neonatal physical therapy. Part I: clinical competencies and neonatal intensive care unit clinical training models. Pediatr Phys Ther. 2009 Winter;21(4):296-307. doi: 10.1097/PEP.0b013e3181bf75ee. PMID: 19923969. Sweeney JK, Heriza CB, Blanchard Y, Dusing SC. Neonatal physical therapy. Part II: Practice frameworks and evidence-based practice guidelines. Pediatr Phys Ther. 2010 Spring;22(1):2-16. doi: 10.1097/PEP.0b013e3181cdba43. Erratum in: Pediatr Phys Ther. 2010 Winter;22(4):377. PMID: 20142700. https://neonataltherapists.com/ https://www.neonatalcertification.com/certification/ https://www.caringessentials.net/ https://www.liddlekidz.org/cimt-certification-advanced-level-2/ https://neonataltherapycertification.com/

Are you ready to revolutionize your approach to weight loss? Join Maria and Tammie for an informative exploration where they reveal the truth about weight management and debunk the myths surrounding it. They share their professional and personal insight into the role of bariatric surgery, dispelling common fears and misconceptions. They emphasize that surgery isn't a quick fix, instead, it's a potent tool that aids in long-term weight loss and boosts overall health.Maria and Tammie present a detailed discussion on GLP-1 analogs that not only regulate blood sugar but also curb your appetite, making weight management a less daunting task. They also shed light on other medications and their effects, emphasizing the importance of understanding these treatments to find the one that suits you best.From exercise routines to the options of diet, medications, and surgery, they present a holistic picture of weight management options. Maria encourages you to explore and find a balance that works best for your individual needs. Maria and Tammie round off the discussion by highlighting the importance of long-term maintenance and addressing the mental aspects of weight management. Let's embark on this weight loss journey, equipped with the right knowledge and tools, and remember, your victories extend beyond the scale. Tune in and let's transform your weight loss journey together.Citations:1. Benaiges D, Goday A, Pedro-Botet J, Más A, Chillarón JJ, Flores-Le Roux JA. Bariatric surgery: to whom and when? Minerva Endocrinol. 2015 Jun;40(2):119-28. Epub 2015 Feb 10. PMID: 25665592.2. Christoffersen BØ, Sanchez-Delgado G, John LM, Ryan DH, Raun K, Ravussin E. Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss. Obesity (Silver Spring). 2022 Apr;30(4):841-857. doi: 10.1002/oby.23374. PMID: 35333444; PMCID: PMC9310705.3. Eisenberg D, Shikora SA, Aarts E, Aminian A, Angrisani L, Cohen RV, de Luca M, Faria SL, Goodpaster KPS, Haddad A, Himpens JM, Kow L, Kurian M, Loi K, Mahawar K, Nimeri A, O'Kane M, Papasavas PK, Ponce J, Pratt JSA, Rogers AM, Steele KE, Suter M, Kothari SN. 2022 American Society of Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) Indications for Metabolic and Bariatric Surgery. Obes Surg. 2023 Jan;33(1):3-14. doi: 10.1007/s11695-022-06332-1. Erratum in: Obes Surg. 2022 Nov 29;: PMID: 36336720; PMCID: PMC9834364.4. Freedhoff, Y. (2014). No, 95 percent of people don't fail their diets. Retrieved from https://health.usnews.com/health-news/blogs/eat-run/2014/11/17/no-95-percent-of-people-dont-fail-their-diets5. Fuentes Artiles R, Staub K, Aldakak L, Eppenberger P, Rühli F, Bender N. Mindful eating and common diet programs lower body weight similarly: Systematic review and meta-analysis. Obes Rev. 2019 Nov;20(11):1619-1627. doi: 10.1111/obr.12918. Epub 2019 Aug 1. PMID: 31368631.6. MacEwan JP, Chiu K, Ahmad NN, Sacks N, Shinde S, Poon JL, Kan H. Clinical, economic, and health-related quality of life outcomes in patients with overweight or obesity in the United States: 2016-2018. Obes Sci Pract. 2023 Dec 13;10(1):e726. doi: 10.1002/osp4.726. PMID: 38263999; PMCID: PMC10804324.7. Mann T, Tomiyama AJ, Westling E, Lew AM, Samuels B, Chatman J. Medicare's search for effective obesity treatments: diets are not the answer. Am Psychol. 2007 Apr;62(3):220-33. doi: 10.1037/0003-066X.62.3.220. PMID: 17469900.8. Martínez-Gómez MG, Roberts BM. Metabolic Adaptations to Weight Loss: A Brief Review. J Strength Cond Res. 2022 Oct 1;36(10):2970-2981. doi: 10.1519/JSC.0000000000003991. Epub 2021 Mar 3. PMID: 33677461.9. Wolfe BM, Kvach E, Eckel RH. Treatment of Obesity: Weight Loss and BariatricSupport the show

In this episode, we delve into the groundbreaking DAMIS trial, exploring the impact of sublingual microcirculation assessment on treatment decisions for ICU patients with shock. We discuss the methodology, findings, and implications of this extensive multicenter study, offering insights into how real-time microcirculatory data influences clinical outcomes in critical care. Join us for an in-depth analysis and expert opinions on this pivotal topic in intensive care medicine. Show Notes: https://eddyjoemd.com/damis-trial-microcirculation/ The Vasopressor & Inotrope Handbook: ⁠Amazon Affiliate Link⁠ (I will earn an extra small commission) and ⁠Signed Copies⁠. Citation: Bruno RR, Wollborn J, Fengler K, Flick M, Wunder C, Allgäuer S, Thiele H, Schemmelmann M, Hornemann J, Moecke HME, Demirtas F, Palici L, Franz M, Saugel B, Kattan E, De Backer D, Bakker J, Hernandez G, Kelm M, Jung C. Direct assessment of microcirculation in shock: a randomized-controlled multicenter study. Intensive Care Med. 2023 Jun;49(6):645-655. doi: 10.1007/s00134-023-07098-5. Epub 2023 Jun 6. Erratum in: Intensive Care Med. 2023 Oct;49(10):1279. PMID: 37278760; PMCID: PMC10242221. This Podcast was edited using Descript: ⁠⁠⁠⁠⁠https://www.descript.com?lmref=BGOxjQ⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/eddyjoemd/support

What is the best surgical treatment for a vasculopathy with critical limb threatening ischemia? In this episode of Behind the Knife the vascular surgery subspecialty team discusses two pivotal trials (BEST-CLI and BASIL-2) and how the findings of these trials can help answer this question. In this episode, we will discuss the age old question: open bypass versus best endovascular treatment.  Hosts:  Dr. Bobby Beaulieu is an Assistant Professor of Vascular Surgery at the University of Michigan Dr. Frank Davis is an Assistant Professor of Vascular Surgery at the University of Michigan Dr. David Schechtman is a Vascular Surgery Fellow at the University of Michigan Dr. Drew Braet is a PGY-4 Integrated Vascular Surgery Resident at the University of Michigan Learning Objectives Review the definition, prevalence, and prognosis of critical limb threatening ischemia Review basic treatment options for patients with critical limb threatening ischemia Understand the methodology, findings, limitations, and clinical applications of the BEST-CLI trial Understand the methodology, findings, limitations, and clinical applications of the BASIL-2 trial Compare open bypass and best endovascular therapy for patients with critical limb threatening ischemia References Farber A, Menard MT, Conte MS, Kaufman JA, Powell RJ, Choudhry NK, Hamza TH, Assmann SF, Creager MA, Cziraky MJ, Dake MD, Jaff MR, Reid D, Siami FS, Sopko G, White CJ, van Over M, Strong MB, Villarreal MF, McKean M, Azene E, Azarbal A, Barleben A, Chew DK, Clavijo LC, Douville Y, Findeiss L, Garg N, Gasper W, Giles KA, Goodney PP, Hawkins BM, Herman CR, Kalish JA, Koopmann MC, Laskowski IA, Mena-Hurtado C, Motaganahalli R, Rowe VL, Schanzer A, Schneider PA, Siracuse JJ, Venermo M, Rosenfield K; BEST-CLI Investigators. Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia. N Engl J Med. 2022 Dec 22;387(25):2305-2316. doi: 10.1056/NEJMoa2207899. Epub 2022 Nov 7. PMID: 36342173. https://pubmed.ncbi.nlm.nih.gov/36342173/ Bradbury AW, Moakes CA, Popplewell M, Meecham L, Bate GR, Kelly L, et al. A vein bypass first versus a best endovascular treatment first revascularisation strategy for patients with chronic limb threatening ischaemia who required an infra-popliteal, with or without an additional more proximal infra-inguinal revascularisation procedure to restore limb perfusion (BASIL-2): an open-label, randomised, multicentre, phase 3 trial. The Lancet. 2023. 401(10390), 1798-1809. https://doi.org/10.1016/S0140-6736(23)00462-2 Conte MS Bradbury AW Kolh P et al. Global vascular guidelines on the management of chronic limb-threatening ischemia. Eur J Vasc Endovasc Surg. 2019; 58 (109.e33.): S1-109 https://pubmed.ncbi.nlm.nih.gov/31182334/ Bradbury AW Adam DJ Bell J et al. Multicentre randomised controlled trial of the clinical and cost-effectiveness of a bypass-surgery-first versus a balloon-angioplasty-first revascularisation strategy for severe limb ischaemia due to infrainguinal disease. The bypass versus angioplasty in severe ischaemia of the leg (BASIL) trial. Health Technol Assess. 2010; 14: 1-210 https://pubmed.ncbi.nlm.nih.gov/20307380/ Adam DJ Beard JD Cleveland T et al. Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial. Lancet. 2005; 366: 1925-1934 https://pubmed.ncbi.nlm.nih.gov/16325694/ Bradbury AW Adam DJ Bell J et al. Bypass versus angioplasty in severe ischaemia of the leg (BASIL) trial: an intention-to-treat analysis of amputation-free and overall survival in patients randomized to a bypass surgery-first or a balloon angioplasty-first revascularization strategy. J Vasc Surg. 2010; 51: 5S-17 https://pubmed.ncbi.nlm.nih.gov/20435258/ Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group. Global vascular guidelines on the management of chronic limb-threatening ischemia. J Vasc Surg. 2019 Jun;69(6S):3S-125S.e40. doi: 10.1016/j.jvs.2019.02.016. Epub 2019 May 28. Erratum in: J Vasc Surg. 2019 Aug;70(2):662. PMID: 31159978; PMCID: PMC8365864. https://pubmed.ncbi.nlm.nih.gov/31159978/ Menard MT, Rosenfield K, Farber A. The BEST-CLI Trial: Implications of the Primary Results. Eur J Vasc Endovasc Surg. 2023 Mar;65(3):317-319. doi: 10.1016/j.ejvs.2022.12.032. Epub 2023 Jan 6. PMID: 36621707. https://pubmed.ncbi.nlm.nih.gov/36621707/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out other vascular surgery episodes: https://behindtheknife.org/podcast-category/vascular/

Contributor: Jared Scott MD Educational Pearls: Should we use opioids to treat low back and neck pain? The OPAL Trial, published in The Lancet, in June 2023, attempted to answer this very question. Objective: Investigate the efficacy and safety of a short course of opioid analgesic (oxycodone-naloxone) for acute low back pain and neck pain. Trial Design: Triple-blinded, placebo-controlled randomized trial, conducted in Emergency and Primary Care in Sydney, Australia, involving adults with 12 weeks or less of low back or neck pain. Participants: 347 recruited adults (174 in the opioid group, 173 in the placebo group) with at least moderate pain severity. Intervention: Participants were assigned to receive either an opioid or a placebo for up to 6 weeks. Primary Outcome: Pain severity at 6 weeks measured with the pain severity subscale of the Brief Pain Inventory (10-point scale). Results: No significant difference in pain severity at 6 weeks between the opioid group (mean score 2.78) and placebo group (mean score 2.25). Adverse events were reported by 35% in the opioid group and 30% in the placebo group, with more opioid-related adverse events in the opioid group (e.g., constipation). Conclusion: Opioids should not be recommended for acute non-specific low back pain or neck pain, as there was no significant difference in pain severity compared with the placebo. The study calls for a change in the frequent use of opioids for these conditions. Pharmacy Pearl: Why was naloxone mixed with oxycodone? Naloxone is an opioid receptor antagonist, meaning it can block the effects of opioids. When combined with oxycodone, naloxone's presence discourages certain forms of opioid misuse. Additionally, naloxone can bind to opioid receptors in the gut and improve symptoms of Opioid Induced Constipation (OIC). This is the same idea behind Suboxone (buprenorphine/naloxone).   References Jones CMP, Day RO, Koes BW, Latimer J, Maher CG, McLachlan AJ, Billot L, Shan S, Lin CC; OPAL Investigators Coordinators. Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial. Lancet. 2023 Jul 22;402(10398):304-312. doi: 10.1016/S0140-6736(23)00404-X. Epub 2023 Jun 28. Erratum in: Lancet. 2023 Aug 19;402(10402):612. PMID: 37392748. Camilleri M, Lembo A, Katzka DA. Opioids in Gastroenterology: Treating Adverse Effects and Creating Therapeutic Benefits. Clin Gastroenterol Hepatol. 2017 Sep;15(9):1338-1349. doi: 10.1016/j.cgh.2017.05.014. Epub 2017 May 19. PMID: 28529168; PMCID: PMC5565678. Summarized by Jeffrey Olson MS2 | Edited by Jorge Chalit, OMSII  

In this two-part episode our team debates management of complex pleural effusions and empyema. Our surgical team is joined by Dr. Jed Gorden, an interventional pulmonologist, as we explore the nuances of deciding on fibrinolytic therapy (part 1) versus surgical management (part 2). Part 1: https://behindtheknife.org/podcast/clinical-challenges-in-thoracic-surgery-complex-pleural-effusions-empyema-part-1-of-2/ Learning Objectives: -Discuss the pros and cons of small bore versus large bore chest tubes for complex pleural effusions  -Review the evidence for fibrinolytic therapy for management of complex pleural effusions -Describe the surgical management of a complex pleural effusion including VATS, open thoracotomy, empyema tube, Eloesser flap, and Clagett window -Create a framework for shared-decision making with patients regarding management of a complex pleural effusion Hosts: Kelly Daus MD, Peter White MD, Jed Gorden, MD and Brian Louie MD Referenced Material https://pubmed.ncbi.nlm.nih.gov/15745977/ Maskell NA, et al. First Multicenter Intrapleural Sepsis Trial (MIST1) Group. U.K. Controlled trial of intrapleural streptokinase for pleural infection. N Engl J Med. 2005 Mar 3;352(9):865-74. doi: 10.1056/NEJMoa042473. Erratum in: N Engl J Med. 2005 May 19;352(20):2146. PMID: 15745977. https://pubmed.ncbi.nlm.nih.gov/21830966/ Rahman NM, et al. Intrapleural use of tissue plasminogen activator and DNase in pleural infection. N Engl J Med. 2011 Aug 11;365(6):518-26. doi: 10.1056/NEJMoa1012740. PMID: 21830966. https://pubmed.ncbi.nlm.nih.gov/35830586/ Wilshire CL, et al. Comparing Initial Surgery versus Fibrinolytics for Pleural Space Infections: A Retrospective Multicenter Cohort Study. Ann Am Thorac Soc. 2022 Nov;19(11):1827-1833. doi: 10.1513/AnnalsATS.202108-964OC. PMID: 35830586. https://pubmed.ncbi.nlm.nih.gov/37043201/ Wilshire CL, et al. Effect of Intrapleural Fibrinolytic Therapy vs Surgery for Complicated Pleural Infections: A Randomized Clinical Trial. JAMA Netw Open. 2023 Apr 3;6(4):e237799. doi: 10.1001/jamanetworkopen.2023.7799. PMID: 37043201; PMCID: PMC10098968. Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out more thoracic surgery episodes here: https://behindtheknife.org/podcast-category/cardiothoracic/

In this two-part episode our team debates management of complex pleural effusions and empyema. Our surgical team is joined by Dr. Jed Gorden, an interventional pulmonologist, as we explore the nuances of deciding on fibrinolytic therapy (part 1) versus surgical management (part 2). Learning Objectives: -Discuss the pros and cons of small bore versus large bore chest tubes for complex pleural effusions  -Review the evidence for fibrinolytic therapy for management of complex pleural effusions -Describe the surgical management of a complex pleural effusion including VATS, open thoracotomy, empyema tube, Eloesser flap, and Clagett window -Create a framework for shared-decision making with patients regarding management of a complex pleural effusion Hosts: Kelly Daus MD, Peter White MD, Jed Gorden, MD and Brian Louie MD Referenced Material https://pubmed.ncbi.nlm.nih.gov/15745977/ Maskell NA, et al. First Multicenter Intrapleural Sepsis Trial (MIST1) Group. U.K. Controlled trial of intrapleural streptokinase for pleural infection. N Engl J Med. 2005 Mar 3;352(9):865-74. doi: 10.1056/NEJMoa042473. Erratum in: N Engl J Med. 2005 May 19;352(20):2146. PMID: 15745977. https://pubmed.ncbi.nlm.nih.gov/21830966/ Rahman NM, et al. Intrapleural use of tissue plasminogen activator and DNase in pleural infection. N Engl J Med. 2011 Aug 11;365(6):518-26. doi: 10.1056/NEJMoa1012740. PMID: 21830966. https://pubmed.ncbi.nlm.nih.gov/35830586/ Wilshire CL, et al. Comparing Initial Surgery versus Fibrinolytics for Pleural Space Infections: A Retrospective Multicenter Cohort Study. Ann Am Thorac Soc. 2022 Nov;19(11):1827-1833. doi: 10.1513/AnnalsATS.202108-964OC. PMID: 35830586. https://pubmed.ncbi.nlm.nih.gov/37043201/ Wilshire CL, et al. Effect of Intrapleural Fibrinolytic Therapy vs Surgery for Complicated Pleural Infections: A Randomized Clinical Trial. JAMA Netw Open. 2023 Apr 3;6(4):e237799. doi: 10.1001/jamanetworkopen.2023.7799. PMID: 37043201; PMCID: PMC10098968. Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out more thoracic surgery episodes here: https://behindtheknife.org/podcast-category/cardiothoracic/