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For decades, depression has often been described as the result of a chemical imbalance in the brain. But how strong is the evidence behind that idea? This episode explores one perspective on an area of medicine that continues to be actively debated and is intended to encourage thoughtful discussion—not to provide individualized medical advice. Today on The Dr. Hyman Show, I'm joined by psychiatrist and researcher Dr. Joanna Moncrieff to examine the science behind the serotonin theory and explore how it shaped modern mental health care. Together, we consider why rethinking our assumptions may open the door to a more complete understanding of depression and recovery. We discuss: • Whether depression is best understood through the lens of a chemical imbalance—or something far more complex • How the serotonin theory shaped modern psychiatry and why it's increasingly being questioned • What current research says about antidepressants, emotional numbing, and informed consent • Why lifestyle, nutrition, trauma, and social connection deserve a larger role in supporting mental health • How a more individualized, whole-person approach could change the way we think about depression and recovery Mental health treatment is deeply personal, and this episode explores one perspective on an area of medicine that continues to evolve. If you're currently taking antidepressants or other prescription medications, don't stop or change your treatment based on this discussion alone. Instead, use it as a starting point for an informed conversation with your healthcare provider. Learn More: Dr. Moncrieff recently participated in an FDA Expert Panel on SSRIs and Pregnancy. If you'd like to explore another perspective on the evidence discussed in this episode, you can watch the panel here. View Show Notes From This Episode Sign up for Dr. Hyman's Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by BIOptimizers, fatty15, Rho, Paleovalley, Pique, and Big Bold Health. Go to bioptimizers.com/hyman and use code HYMAN to save 15% off your order, plus get a free gift. Head to fatty15.com/hyman today and use code HYMAN for 15% off your 90-day subscription Starter Kit. Explore science-backed products at rhonutrition.com and use code HYMAN for 20% off the entire site. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 20% off plus free gifts. Go to bigboldhealth.com/drhyman and use code HYMAN15 to save 15% on your first order. (0:00) The impact of the chemical imbalance theory and myths of mental illness (2:02) Disclaimers and introduction of Joanna Moncrieff (3:00) The serotonin myth, antidepressant use, and marketing of SSRIs (16:12) Risks, side effects, and wrong-headed approaches to mental health (21:00) Societal, biological, and lifestyle factors in mental health (27:13) Commercial determinants of health (30:49) The rise and implications of psychedelic treatments in psychiatry (43:21) Drug-centered vs. disease-centered models in mental health (45:40) The role of the brain and alternative approaches to treating depression (50:00) Addressing severe depression and strategies for deprescribing antidepressants (54:41) Reframing mental health narratives and future outlook (57:09) Encouraging self-education, debate, and discussion in medicine (59:23) Closing remarks, disclaimers, and gratitude to sponsors
Declan Buckley, Édaein O'Connell and Seán Moncrieff help tackle listener dilemmas!
Every Wednesday, Cassie Delaney will join to tell unusual stories on heinous crimes…This week, Cassie joins guest host Tom Dunne to discuss cases where the weather was an accomplice, a witness, and, in one case, the detective!
Every Wednesday, Cassie Delaney will join to tell unusual stories on heinous crimes…This week, Cassie joins guest host Tom Dunne to discuss cases where the weather was an accomplice, a witness, and, in one case, the detective!
TV Reviewer James Dempsey joined Seán Moncrieff for the weekly TV review slot, TV on the Radio…
Declan Buckley, Édaein O'Connell and Seán Moncrieff help tackle listener dilemmas!
Child Psychotherapist Joanna Fortune joins Seán Moncrieff to answer your parenting questions…
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss cases involving cults and different beliefs.
Once upon a time, friendships almost happened by accident. You met people through school, work, or as a childhood friend. Today, we're more connected than ever. We can stay in touch with friends living on the other side of the world in seconds. But making new friends as adults often feels surprisingly difficult. Have we forgotten how to make friends, and has it become easier or harder as time's gone on? Presenter Muireann O'Connell and comedian Pat Shortt join Sean Moncrieff on Then V Now to discuss.
Child Psychotherapist Joanna Fortune joins Seán Moncrieff to answer your parenting questions…
Once upon a time, friendships almost happened by accident. You met people through school, work, or as a childhood friend. Today, we're more connected than ever. We can stay in touch with friends living on the other side of the world in seconds. But making new friends as adults often feels surprisingly difficult. Have we forgotten how to make friends, and has it become easier or harder as time's gone on? Presenter Muireann O'Connell and comedian Pat Shortt join Sean Moncrieff on Then V Now to discuss.
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss cases involving cults and different beliefs.
Jonathan DeBurca Butler joins Seán Moncrieff to take listeners through the week's international stories…
TV Reviewer James Dempsey joined Seán Moncrieff for the weekly TV review slot, TV on the Radio…
Are we better at communicating than we used to be back in the day? We can send a message across the world in seconds, stay in constant contact, and never be more than a phone call away. But are all those ways of connecting actually bringing us closer together? From texting versus calling, to the art of letter writing, Sean is joined by author Barbara Scully and comedian Shane Daniel Byrne to explore whether modern life has made us better communicators or whether we were actually better at it in the past.
Barbara Scully, Declan Buckley and Seán Moncrieff help tackle listener dilemmas!
Are we better at communicating than we used to be back in the day? We can send a message across the world in seconds, stay in constant contact, and never be more than a phone call away. But are all those ways of connecting actually bringing us closer together? From texting versus calling, to the art of letter writing, Sean is joined by author Barbara Scully and comedian Shane Daniel Byrne to explore whether modern life has made us better communicators or whether we were actually better at it in the past.
Child Psychotherapist Joanna Fortune joins Seán Moncrieff to answer your parenting questions…
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss cases where the internet worked together to solve mysteries…
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss cases where the internet worked together to solve mysteries…
Child Psychotherapist Joanna Fortune joins Seán Moncrieff to answer your parenting questions…
Jonathan DeBurca Butler joins Seán Moncrieff to take listeners through the week's international stories…
TV Reviewer James Dempsey joined Seán Moncrieff for the weekly TV review slot, TV on the Radio…
Nick talks to Jean Moncrieff, CEO of the Small Giants Community and author of Finding Freedom, who shares his personal journey of building a company, almost losing it through an ill-advised exit, and eventually selling it successfully to his management team. The conversation explores how business owners can build high-value, purpose-driven companies that offer genuine lifestyle freedom. Jean and Nick dive deep into the crucial role of alignment, the psychology of leadership, and how to successfully navigate different exit options—including employee ownership models—by cultivating a high-performing leadership team. KEY TAKEAWAYS To successfully scale a business, founders must shift their mindset from needing to be the smartest person in the room to intentionally surrounding themselves with leaders who are highly capable of running things independently. When building a leadership team, alignment with the company's core values and unique culture is just as critical as a candidate's tactical skills and job capabilities. As an unprecedented wave of baby boomer business owners look to retire, a severe shortage of capable incoming leaders is creating a significant leadership vacuum. True financial and lifestyle freedom is achieved by systematically executing three distinct phases in order: exiting daily operational chaos, exiting the business's management operations, and finally, executing the financial exit of the business itself. BEST MOMENTS "Feed me, John, feed me... I was chasing output, I was chasing revenue... and I thought that's what this was all about." "You don't want to control your business, you want to be able to curate above it; you want to be in charge, but control is bad because you're stuck in everything." "I think it's almost like sticking a light bulb into the socket, and if the wiring's done right, the thing lights up." "The quickest way that I advise the founders that I work with to get to where they want to get to is bring the person who's done it. Bring the person in... and then get out of the way." VALUABLE RESOURCES Want to grow and scale your business? Check out Nick's Boardroom Program: https://gamma.app/docs/BOARDROOM-2026-FINAL-h2vknz5qne7vvwm To get your copy of Nick's book, Exit for Millions, go to http://bit.ly/4ngC2hO Nick's LinkedIn: https://www.linkedin.com/in/realnickbradley Nick Bradley is a world-renowned author, speaker, and business growth expert, who works with entrepreneurs, business leaders, and investors to build, scale and sell high-value companies. He spent 10+ years working in Private Equity, where he oversaw 100+ acquisitions, 26 exits, and over $5 Billion in combined value created. He has one of the top-ranked business podcasts in the UK (with over 1m downloads in over 130 countries). He now spends his time coaching and consulting business owners in building and scaling high-value business towards life-changing exits. This Podcast has been brought to you by Disruptive Media. https://disruptivemedia.co.uk/
Barbara Scully, Pádraig Wilson McCarthy and Seán Moncrieff help tackle listener dilemmas!
Triggernometry is proudly independent. Thanks to the sponsors below for making that possible: - We use Ground News to escape the echo chamber and stay fully informed. Go to https://ground.news/triggernometry to save 40% on the Ground News unlimited access Vantage plan. - Truewerk: performance work clothes. Get 15% off with Code:TRIG at https://truewerk.com - HIMS: Hair loss treatment, go to https://hims.com/trigger Join our exclusive TRIGGERnometry community on Substack! https://triggernometry.substack.com/ OR Support TRIGGERnometry Here: Bitcoin: bc1qm6vvhduc6s3rvy8u76sllmrfpynfv94qw8p8d5 Shop Merch here - https://shop.triggerpod.co.uk/ Advertise on Triggernometry: https://trigger-brands.com | or enquire at marketing@triggerpod.co.uk Find TRIGGERnometry on Social Media: https://twitter.com/triggerpod https://www.facebook.com/triggerpod/ https://www.instagram.com/triggerpod/ About TRIGGERnometry: Stand-up comedians Konstantin Kisin (@konstantinkisin) and Francis Foster (@francisjfoster) make sense of politics, economics, free speech, AI, drug policy and WW3 with the help of presidential advisors, renowned economists, award-winning journalists, controversial writers, leading scientists and notorious comedians. Learn more about your ad choices. Visit megaphone.fm/adchoices
Child Psychotherapist Joanna Fortune joins Seán Moncrieff to answer your parenting questions…
Was finding a partner easier in the past? People met through friends, work, or local clubs. Today, dating apps put thousands of potential matches at our fingertips. But has more choice made it easier to find love? Sean is joined by broadcaster Mary Kennedy and radio presenter Emily McEvoy on Then V Now with Moncrieff to compare dating across two different generations.
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss cases where hobbies became fatal…
TV Reviewer James Dempsey joined Seán Moncrieff for the weekly TV review slot, TV on the Radio…
Declan Buckley, Barbara Scully and Seán Moncrieff help tackle listener dilemmas!
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss cases of creepy twins who committed crimes.
TV Reviewer James Dempsey joined Seán Moncrieff for the weekly TV review slot, TV on the Radio…
Declan Buckley, Édaein O'Connell and Seán Moncrieff help tackle listener dilemmas!
Child Psychotherapist Joanna Fortune joins Seán Moncrieff to answer your parenting questions…
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss cases where people disappeared, but later came back.
The 2026 wedding season is here for some, and approaching for others. So, what do you need to know so things don't go pear-shaped?For this week's ‘Moncrieff's Wedding Survival Guide', Sean is joined by Laura Jordan, Image and Brand Consultant and owner of Style Savvy to discuss how you should dress when going to a wedding!
Declan Buckley, Édaein O'Connell and Seán Moncrieff help tackle listener dilemmas!
Child Psychotherapist Joanna Fortune joins Seán Moncrieff to answer your parenting questions…
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss cases of con artists in Ireland!
The 2026 wedding season is approaching. So what do you need to know so things don't go pear-shaped?For this week's ‘Moncrieff's Wedding Survival Guide', Sean is joined by Gina London, former CNN White House Correspondent and Sunday Independent Columnist, to discuss what you need to be aware of if you're giving a speech!
Child Psychotherapist Joanna Fortune joins Seán Moncrieff to answer your parenting questions…
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss crimes where the perpetrator was caught in unexpected ways!Image: HBO
"Tell them that you love them."Charlie McKean, a father, sailor, State Solicitor, and brother of Newstalk's Henry McKean, died suddenly of a heart attack last month, at the age of 46.Henry speaks with Moncrieff, surrounding National Brother's Day, about the heartbreak of losing a sibling...
Liz does a deep-dive into regional spatial planning, which is a new mandated requirement in the Planning Bill.
Child Psychotherapist Joanna Fortune joins Seán Moncrieff to answer your parenting questions…
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss interesting crimes involving words!
The 2026 wedding season is approaching. So, whether you're simply a guest or the bride-to-be, what do you need to know so things don't go pear-shaped?For this week's ‘Moncrieff's Wedding Survival Guide', Sean is joined by Wedding Expert, Sara Kennedy, to discuss what to do when things go wrong…
Child Psychotherapist Joanna Fortune joins Seán Moncrieff to answer your parenting questions…
Every Wednesday, Seán will be joined by someone to hear unusual stories on heinous crimes…This week, Cassie Delaney joins to discuss interesting cases which have remained unsolved to this day…