Podcasts about framingham

Coco starts the news for the morning. Why a man in Framingham is the worst dog owner on the planet and the Lindsay Clancy Judge is trying to protect the jurors.

Conan and special guest Andy Daly chat with Peter in Framingham, MA about working for the CPCS Innocence Program, the best sources of DNA, and how to bring comedy into difficult conversations. Wanna get a chance to talk to Conan? Submit here: teamcoco.com/apply Get access to all the podcasts you love, music channels and radio shows with the SiriusXM App! Get 3 months free using this show link: https://siriusxm.com/conan. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Send us Fan MailWhat happens when your side hustle becomes the thing you can't stop thinking about?In this episode of the Ski Moms Podcast, Nicole catches up with Charlotte Lilley, founder of The Retreat Co., to talk about leaving the corporate world, growing her women's ski retreat business, and creating intentional outdoor experiences where women can adventure, connect, and try something new.Charlotte first joined the podcast when The Retreat Co. was still The Ski Retreat. Since then, she's gone all-in on entrepreneurship, expanded beyond ski trips into year-round women's adventure retreats, and started building Serene Ravine, a 90-acre property near Lake Tahoe that she envisions as a future home for retreats, camping, glamping, dinners, weddings, and other outdoor experiences.There's also some big Ski Moms news: The Retreat Co. and Ski Moms are partnering on upcoming women's ski retreats and events.What You'll Learn From This EpisodeHow Charlotte turned a six-year side hustle into her full-time career and grew The Ski Retreat into The Retreat Co.Why small, intentional women's retreats can create friendships that last well beyond the weekend.What to expect from a women's ski retreat, including accommodations, meals, activities, skiing, lessons, rentals, transportation, and rooming options.Why learning something new as an adult—whether it's skiing, camping, or mountain biking—can build confidence and connection.How Ski Moms and The Retreat Co. are partnering to create more thoughtful, community-focused ski experiences for women.One of Charlotte's biggest lessons? You don't have to wait until you already have the ski friends to take the ski trip. Sometimes you take the trip to find the ski friends.Ready for your next Ski Moms adventure? Visit TheSkiMoms.co/events to see upcoming events and retreats.Scheduling at Ski Haus is open! Appointments start Saturday, 9/12. Available for kids 16 & under, includes skis /poles or a snowboard, boots + bindings. Make a separate appointment for each child at Ski Haus in Salem, NH; Framingham or Woburn, MA. Bonuses: Free Jr Season Pass Black Mtn (10 & under)$99 Jr Season Pass Tenney Mtn (13 & under)Fee Jr Lift Ticket Cranmore MtnMORE! This season, don't just see the fall—experience it. Plan your Ulster County adventure at visitulstercountyny.com. Register by September, 2026, and use code SKIMOMSRETREAT to save $100 on your trip*Visit www.theskimoms.co/events to see the 2027 lineup and reserve your spot.*discount only available for full payment, not deposit. Get the best gear recommendations and trip-planning tips directly to your inbox. Head to skimom.substack.com to subscribe. Join for free—or upgrade for all the premium perks. Premium subscriptions start at just $5 a month and get to listen ad-free and unlock exclusive content, including insider travel guides, packing lists and more. Support the showKeep up with the Latest from the Ski Moms!Website: www.theskimoms.coSki Moms Discount Page: https://www.theskimoms.co/discountsSki Moms Ski Rental HomesJoin the 13,000+ Ski Moms Facebook GroupInstagram: https://www.instagram.com/theskimoms/Send us an email and let us know what guests and topics you'd like to hear next! Sarah@skimomsfun.comNicole@skimomsfun.com

Dr. Andrew Holman is a rheumatologist and the CEO of Seattle-based Inmedix, which recently received FDA clearance for the first cloud-based heart rate variability (HRV) diagnostic platform. Dr. Holman shares how a “detective” mindset led him from early interests in orthopedics and cardiology into rheumatology, fibromyalgia research, and ultimately entrepreneurship. He explains how chronic stress, the autonomic nervous system, and conditions like sleep apnea and restless leg syndrome can influence cardiovascular risk and autoimmune disease outcomes, and why measuring stress biology with medical-grade precision matters. Dr. Holman also offers hard-earned advice for physician-innovators, reflects on pivotal study results, and shares what he hopes to be remembered for: never dismissing patients in distress.  Guest links: https://www.inmedix.com | https://www.linkedin.com/company/inmedix-inc Charity supported: Save the Children Interested in being a guest on the show or have feedback to share? Email us at theleadingdifference@velentium.com.  PRODUCTION CREDITS Host & Editor: Lindsey Dinneen Producer: Velentium Medical   EPISODE TRANSCRIPT Episode 088 - Andrew Holman [00:00:00] Lindsey Dinneen: Hi, I'm Lindsey and I'm talking with MedTech industry leaders on how they change lives for a better world. [00:00:09] Diane Bouis: The inventions and technologies are fascinating and so are the people who work with them. [00:00:15] Frank Jaskulke: There was a period of time where I realized, fundamentally, my job was to go hang out with really smart people that are saving lives and then do work that would help them save more lives. [00:00:28] Diane Bouis: I got into the business to save lives and it is incredibly motivating to work with people who are in that same business, saving or improving lives. [00:00:38] Duane Mancini: What better industry than where I get to wake up every day and just save people's lives. [00:00:42] Lindsey Dinneen: These are extraordinary people doing extraordinary work, and this is The Leading Difference. Hello, and welcome back to another episode of The Leading Difference podcast. I'm your host, Lindsey, and today I'm delighted to be welcoming as my guest Dr. Andrew Holman. Dr. Holman is a rheumatologist and the CEO of Inmedix, a Seattle-based medical diagnostics company that recently received FDA clearance for the first cloud-based heart rate variability diagnostic platform. He has 25 years of clinical experience with 16 peer-reviewed papers and clinical trials demonstrating that measuring stress biology with medical grade precision can improve success rates in autoimmune diseases. All right. Andrew, welcome to the show. I'm so glad you're here today. [00:01:30] Andrew Holman: Yes, happy to be here. Thank you for inviting me. [00:01:33] Lindsey Dinneen: Course, of course. Well, I would love, if you wouldn't mind starting out telling us a little bit about who you are, what your background is, and what led you to medtech. [00:01:44] Andrew Holman: Sure. Well, I'm a, a guy from Seattle, Washington. Grew up here, but trained everywhere else, became a rheumatologist. We study autoimmune diseases, lupus, rheumatoid arthritis. I also was very interested in fibromyalgia and pain. We're the immunologists of medicine. So, I started my practice, golly, a while ago. 1992, I finished my prac- my training, and I was the main rheumatologist at a large suburban hospital at the southern end of Seattle. So hometown, circle back to the hometown. I went into rheumatology because you have many choices when you do internal medicine. You can go be a specialist in many things. But I like the puzzles. The immunology has grown and it's a, it's a particularly sort of detective-oriented specialty. So, I didn't set out to be an entrepreneur. That came 25 years later. I was an in-the-trenches doc trying to help the person in front of me with these devastating diseases that are crippling diseases, usually of young women mostly. [00:02:45] Lindsey Dinneen: Yeah. Okay, and I'm sure there's, there's much more we're gonna dive into, but one thing that really stood out really fast was you, you kind of called yourself a detective, which I really love that term. And so I'm curious, is that something that you always thought you wanted to specialize in, in medicine, or was this, you know, detectiving to come later? Was this something that, you know, you ended up learning more about while in med school and thought, "Oh, this sounds really cool. I could put really two interesting passions together"? [00:03:19] Andrew Holman: Yeah, it was-- you know, things just sort of come into play sometime. For those who are not in medicine, they may not realize it takes about ten years to go to college, med school, re- internship, residency, fellowship, you know, and then you, then you finally get to go be a doctor, and you have to go learn how to be a doctor s- a little more. The patients teach you a lot more than people realize. So I was gonna be an orthopedist. I liked orthopedics. I liked architecture, bones, joints. I thought it was a lot of fun. I just had very little aptitude for what they do. I, I don't-- I, I'm not very g- a good carpenter. I just, you know, I didn't-- just wasn't gonna be a great orthopedist. So then I thought, "I really love cardiology." Rhythm disturbances, all kinds of things. In the 1980s, when I was in medical school , all the new stents and procedures and non- less invasive things than bypass surgery were all coming up. Joint valve replacement. You know, it's really exciting. But I never... and I never took a, a f- a course in rheumatology until I was actually an intern in internal medicine program in Denver, all set to be a cardiologist. And there were 12 of us in the, in the program per year, and s- five of us became rheumatologists because of this one doctor who took us out, a guy named Daryl McCarter. Prob- maybe people who know him, he's retired recently. He would bring us in the office, and we'd see every other patient with him because in between the patients, he would give us an X-ray, say, "I want you to look at this. There's a clue here. See if you can find it." Or, "I want you to look at this pathology slide," or something. "There's a secret, you know, to figure this one out." And I go, "Wow, this is really fun stuff." And once you figured it out, we weren't as good at treating it yet, but we were getting better. We were getting better. So it was the cutting edge and very fertile ground for discovery. So, rheumatologists are called the consult of last resort for a reason. There aren't very many of us. You've usually seen everybody else first, and by the time they-- you see us, we're pretty good at figuring out the rare diseases that are not in other people's board exam. But we're also pretty good at figuring out the common disease that presents in a very strange way, you know? And, and that's what our strength is. So we may... Everybody who sees us who gets diagnosed may not have a rheumatology answer, but we try to get them an answer. And now we're really in the golden age of rheumatology in the last 20 years of really making a difference for so many people. The downside, we don't make a difference for enough people, you know? We, we... That's the problem. So we've got these very motivated doctors out there, eager, and we just need, you know, more. And that's why I became an entrepreneur, because I learned more neurology than I was supposed to know and more sleep physiology than I was supposed to know. You just follow the breadcrumbs, you know? [00:06:17] Lindsey Dinneen: Yeah. Okay, so I know you didn't start out wanting to, or maybe even being interested in being an entrepreneur, but that is the path that you chose, and I would love to hear about that, the company, and what you're all doing. And then also would love to hear about your journey into deciding that this is the next right step for me. [00:06:38] Andrew Holman: Yeah. Well, thanks for asking it. It is a little unusual. So I was actually studying and trying to help patients with fibromyalgia about 30 years ago. And fibromyalgia patients terribly dismissed till they're all making this up. There's not 10 million people that can make anything up and be consistent. I mean, they all say the same thing. So I thought that was nonsense, and I was really thrown into the crowd of, you know, "You're, you're crazy too." And I go, "Well, I'm board certified in crazy." So I w- I was interested in it, and I was irritated that these people were dismissed. And I was around other doctors in Seattle who were similarly that way, which was very, very unusual. It's unusual to find people in the '90s who had an avid interest in that disorder. And so I started doing what rheumatologists are good at, incrementally advancing ideas and therapeutics very carefully, very cautiously. We do a lot of things off-label. When I was-- finished my fellowship in 1992, half the diseases on our board exam had no FDA-approved treatment. We had to do something, right? You couldn't just say, "Well, come back when there's a couple of articles in the New England Journal of Medicine." You, you can't do that, right? People are depending on you. So rheumatologists are particularly good at that, and that's not something most doctors want to do. Most doctors find that very uncomfortable. They're very, very careful people. And, and rheumatologists are careful too, but we take this mission seriously that we need to do something for you. So basically, I was looking at off-label ideas and work on fibromyalgia, and I'll share this with your audience. I was actually pulled up-- pulled in by some senior doctors who said, "We wanna talk with you." And I'd been there about three years as a new doctor. Oh, you know, seem to be doing a good job. Maybe they wanna pat me on the back or something. No, not that. It was actually an intervention, which I had never... I mean, I had no familiarity with what an intervention was. And they said, "Look, we like you. You're a great doc, but you're gonna ruin your reputation if you believe all these people, mostly women And you really need to not take it so seriously or write prescriptions for this c-- this and that." I said, "Well, thank you very much." That's polite. That's not what I was thinking. And I, I... But it prompted me to pull all the charts and say, "You know, I think I'm making some progress here with some ideas here, and let me see if I'm getting fooled and just seeing the people who get better to come back. Let me really honestly look at my performance." And so I pulled about 200 charts. It was my first abstract at the national meeting. And you know what? We were making progress. That had morphed into more progress, following the breadcrumbs, looking at neurology, looking at the autonomic nervous system. So that was about a five-year process. Y-you know, I didn't lose my reputation, obviously. I lecture around the world now. But it led to being very careful about getting clinical evidence if I had a hypothesis. And so we were using the office, and we actually finally did a double-blind prospective study where I bought all the drug myself, had it reformulated, little capsules that, you know, and, and worked with the FDA to get permission to do the study. And that study in fibromyalgia to this day has the highest response rate of any fibromyalgia study for pain that's ever been done. Now, we don't use that treatment anymore. It's 20 years later, we have other things to do. But it did prompt Pharmacia, got bought by Pfizer, I believe, and Boehringer Ingelheim, which co-marketed the drug I was using and reporting on, to pay me $10 million for the patents that I had filed, utility patents. I didn't own the drug. I didn't use it for Parkinson's disease, but I thought there was use in fibromyalgia. So before I told the world, I filed utility patents, and they wanted to exploit that discovery. So did two other pharmaceutical companies, and they had to pay for the privilege of doing it. So at 46, I retired. So I didn't intend to do that, but I do come from a family of lawyers and judges, and so the idea of having a utility patent on a n- a new innovative idea was not a foreign concept to me. [00:10:40] Lindsey Dinneen: Yeah. [00:10:41] Andrew Holman: That is something I teach all young doctors. [00:10:46] Lindsey Dinneen: That is awesome, and I, I was thinking, okay, this is a great segue because first of all, that's an incredible story. Secondly, I, I would be very curious to know exactly that, what is your advice for some of these incredible physicians, great ideas, that are potentially going to end up becoming an entrepreneur just because that's the path that, that is sort of presented to them? What is some of your advice for that? 'Cause that can't just be... you, you had the privilege at least of, of, of knowing and having some background in that, the legal aspects of IP protection and whatnot, but what are some of the things that you tell people? [00:11:22] Andrew Holman: Well, a couple things I would say and I have these conversations often 'cause I really like the younger people coming along. I say, first of all, don't define yourself as an ent- as being an entrepreneur. Make sure you have other things in your life that are more important to you. Now, the investors are not gonna like to hear that. They, they want you to live and die on your, on your company, right? But I'm saying, you know, you don't have to tell the VCs, but have other things that matter more in your life. You still gotta work really hard because you may, you may find that it's really a slog, and it's very long, and it's very hard. But, you know, make sure that, that, that what you-- though is important, your family, you know, your integrity the scientific problem at hand, the patients, you know, they're number one. Make sure we don't lose sight of all that, and do a few things. Go for a walk. Do something for yourself. Something. I do this twenty-four seven for the last 10 years, you know, every day 'cause I love doing it. It does wear you out, though. Even if you make-- even if you're successful with milestones, it does wear you out. But that's what I tell them. I say, "You know, make sure that you take care of yourself a little bit, too." It's kinda like a analogy. What do you do for a pregnant woman who has a, who has a, a lupus? Lupus is terribly dangerous for the fetus and for the mom. Though the worst thing you do to-- for the baby is not take care of the mom. Take care of mom, [00:12:44] Lindsey Dinneen: Mm-hmm. [00:12:45] Andrew Holman: then get the baby delivered. So, you know, everybody's talking about the baby, but take care of mom. That's the most important thing you do for that baby. So that's kinda what I would say. [00:12:54] Lindsey Dinneen: Yeah. Yeah, that's great. I appreciate that. Yeah, that, that makes a lot of sense too. We've been talking, actually it's been a, a bit of a theme too lately in some of the conversations that I've been having with folks, especially leaders, to talk about that identity component and, and be aware that your job isn't the only thing that defines you or needs to. There's a lot more to your life. There's a lot more to who you are. And so also, you know, our identities change over time and how you refer to yourself and th- those are, those are good things. That's growth, that's movement. So, being comfortable with who you are outside of your career. Yeah. [00:13:33] Andrew Holman: The other thing too is, you know, people used to joke 20 years ago that participation mem- medals were like a farce and what. That's the l- that's the last thing I would say to anybody. Give yourself a pat on the back for going out there trying to attack the castle, you know. Give yourself some credit there because a lot of people just wouldn't do it. My middle daughter was a hundred-meter hurdler at Boise State. She's a Division I athlete. There's a lot of sprinters out there that don't wanna get anywhere near that hurdle 'cause it really hurts when you hit it, right? And so half of that was not-- was being brave. So be brave, be brave, you know. My other daughter was a Division I athlete at Rice. She was a h- she was a volleyball player. Yeah. So, yeah. So I, I, I, I watch other people, see how they persevere and, you know, okay, gotta pick yourself up. Gotta go. Gotta get up this morning. Gotta go. [00:14:23] Lindsey Dinneen: That's right. That-- Yeah. [00:14:25] Andrew Holman: Then remember, people are depending on you, not just your investors. I take that so seriously. But the s- the people who have decided that they're gonna hook their wagon to you. [00:14:34] Lindsey Dinneen: Yeah. [00:14:35] Andrew Holman: You know, that's a lot of responsibility. [00:14:37] Lindsey Dinneen: It is. Yeah. [00:14:38] Andrew Holman: Give yourself a little credit that you're stepping up. [00:14:41] Lindsey Dinneen: Yes. Great advice. Yeah. Okay, so all right. So let's talk about your company now. So now you're an entrepreneur, in addition to obviously the rest of who, what makes you, you. But and I know that you're also a clinical professor, and I would love to hear about both of those things if you don't mind sharing. [00:14:59] Andrew Holman: Yeah, sure. So, technically I'm an associate clinical professor at the University of Washington. A, a lot of private docs do, and they participate in helping teach the y-young residents and fellows and so forth. So it's a joy to me. I, I think my job is a job of teaching. I'm constantly talk... I'm not-- I don't see patients anymore, although I do maintain my license in malpractice 'cause I get, I get contacted for the fibromyalgia work I did. So it's, my email's on the papers, right? So I, I don't wanna let that go. People need help. But basically, we're constantly teaching patients, you know. Now, we're listening, hopefully do better and better at that, but then I have to make a case. You know, I'd, the-- I'd like you to try this or that. Why do I wanna do that and so forth. We're constantly, you know... We don't-- It, it sounds too trite to call it selling something. We're not doing that. We're in there with you. We're collaborating. But I have to be, I have to have a reason and be persuasive and all that, so that, that academic teaching part's kind of fun. Now, sometimes I go into the lion's den. I will tell you, it's a little nerve-wracking to give rheumatology grand rounds at Harvard. Yeah, yeah, okay. You know, and the University of Washington, they're a little friendlier. It's my hometown. But Guy's Hospital in London and the Hospital for Special Surgeries, I... My first rheumatology grand rounds came at the HSS in 2009. I get there, I completely bomb. All these famous people are in the front row. I'm... They're, they're just not buying any of this thing we call immunoautonomics and how stress affects the immune system. I'm quoting the NIH. I'm doing everything I... I know how to do it, right? Pathology slides, I'm there. Then I find out the way they pick the speakers is the fellows get to find something interesting, and they pick the speakers, not the not the high mucky-mucks. So the only reason I was there is because the fellows, the young folks, thought, "This is an interesting topic. We'd like to hear more." And it turns out they were 15 years ahead of the rest of the world, because this is the most fascinating topic of how the immune system affects the autonomic nervous system affects the immune system, so it inflames it. [00:17:03] Lindsey Dinneen: Yeah. Oh my gosh. Actually, that is one thing I wanted to talk about, 'cause I, I noticed on your LinkedIn profile there was, you know, a reference to how much stress affects cardiovascular health maybe particularly chronic stress. And I would just love to hear more about that and, and maybe some ways... I know there's like, y- of course you always get your standard, "Here are some things that you could do to lower your stress." But, but from your perspective as a physician who's studied this, I'd love to hear more from you about, okay, how does this affect health, especially cardiovascular health, and then really what are some practical things that we can do? [00:17:39] Andrew Holman: Yeah, let me see what I can do. Now I wish I could fast-forward because we will have some magnificent things in the next five to 10 years based on what's being discovered now. But the bottom line is, stress and pain are awful things, but they have a purpose in the near term. So pain is good because it'll keep you from putting your hand back in the fire, right? Just don't do that again. But chronic pain is terrible and not productive. Stress is the same thing. You wanna get away from the lion. You, you, you need to perform. If your child needs you, whatever, you, you need to perform on it instant. But chronic stress is not productive. The problem with the stress response is it's controlled in the brain by the autonomic nervous system, which is called the ANS, and it's divided into two components, the sympathetic fight or flight, which we all know what that feels like. You know, ooh, scary. And the other is the parasympathetic, which is getting more talk now, which is the opposite, which is related to rest, restorative, sleep, recovery, growth hormone, all these things. And both of these systems are on simultaneously all the time, but they jockey for predominance depending on what the demands are around you, right? So turns out the sympathetic part has a significant negative impact on cardiovascular health, as you might expect, right? If you're driving your car at five thousand RPMs-- now, nobody has a stick shift anymore-- but if you're driving at five thousand RPMs, you're gonna wear down your engine, even if you go at the same speed as someone who has a two thousand RPMs, right? It, it's, it's what's going on inside the hood there is really important. So stress responses chronically do have measurable, tangible, well-published effects on cardiovascular mortality in long prospective studies. So if we had a magic something, we would do something to lower that epinephrine adrenaline response. Unless, of course, you're in the military, where someone's-- you need every heightened, m-- you know, response that you can get to survive. But for the rest of us, it's better that that system does not ramp up and activate. And we all have a different propensity to how powerful it is and how much it turns on, and also how poorly it turns off. So the stress response, we think of it like epinephrine, adrenaline. That's the easiest way to do it. So what you'd wanna do is to make sure this magnificent part of your brain that is your-- does all your housekeeping functions, this autonomic nervous system, the command and control center that you just wanna work, you don't wanna think about it, is not on a turbocharged, right? And there are people I take care of that they were just born that way. A lot of them, by the way. So things like all the wellness opportunities you can think of are, are targeted just to simply calm the autonomic nervous system. Tai chi, meditation, diet, exercise, all these things have been around for thousands of years because of that. That's what they do. And the practitioners will share that with you. I mean, the there are monks that can lower their heart rate, you know, to like, you know, what would seem lethal to the rest of us, right? That's the parasympathetic drive that lowers heart rate, lowers blood pressure. So those wellness opportunities are real. It will be important that you can manage whether the-- what you're doing is working or not. [00:21:04] Lindsey Dinneen: Mm-hmm. [00:21:04] Andrew Holman: Right? And that's where my company comes in. But the other is things like obstructive sleep apnea. You might think heavy guys... See, someone's gonna send me for a sleep study for sure, but they're not gonna send you. Big mistake, because it turns out that fifty-three percent of Japanese women with rheumatoid arthritis have unexpected obstructive sleep apnea. Oops. And, and we were just taught that we wouldn't even check those people. Well, turns out sleep apnea untreated is a major cardiovascular risk factor equal to cigarette smoking, according to the Sleep Heart Health Study in 2004. That's a big deal. And also, we learned in rheumatoid arthritis, getting back to my work, world, that patients with rheumatoid arthritis don't die from joint disease, they die from premature heart disease. They can also get cancers. So why is that? Well, there's been a lot of effort to try to figure that out in the last twenty-five years, and their risk factors for cardiovascular disease are not explained by the Framingham risk factor of hypertension, cholesterol, smoking, and all the things we, we look, see. But nobody looked at sleep apnea. [00:22:15] Lindsey Dinneen: Mm-hmm. [00:22:17] Andrew Holman: The other reason it's so relevant, though, is sleep apnea is a potent sympathetic arousal. It, it-- You struggle to breathe, right? You kind of obstruct. And what part of your brain tells you to breathe? Your autonomic nervous system. Breathe, right? And it stimulates this adrenaline response over and over and over, and it pounds your heart over the years, and it can lead to sudden death and arrhythmias. So there's a, there's a link there. Never miss sleep apnea. The other one is we found in our office and published about restless leg syndrome. You know, people tap their toes in the airport or they kick the covers around at night. It's pretty benign for most people, but it looks like it very well might be a sympathetic arousal, and there may be relevance there. The therapies for that may have relevance to what we're talking about. Again, very off-label. We're not talking about FDA-approved here. But it-- You ask what can you do? The other one that's coming is vagus nerve stimulation. That is FDA-approved now for rheumatoid arthritis, and they're going to other opportunities to, again, to, to increase the parasympathetic and to lower the sympathetic, right? So that background activity doesn't harm you. The autonomic nervous system may be the primary reason that two patients respond differently to the same treatment. What you bring to the table. It's no different than if I have two people coming to me for a back problem. One is five foot three and one is seven foot three. The way their spine is designed makes it a whole lot harder to treat the seven-foot back, right? I'm not surprising anybody here. So there are things that the patients can bring to the table that matter. Here's the irony. Ninety-seven percent of patients with rheumatoid arthritis in a survey in England said that stress affected their disease activity. It's no surprise to them. And sixty-five percent said they thought it predated getting the disease, that it actually contributed to getting it in the first place. And now there's evidence to suggest that may be true. [00:24:17] Lindsey Dinneen: Oh, boy. [00:24:19] Andrew Holman: So we can't miss sleep apnea just out there. We can't miss restless leg. We can't miss Ehlers-Danlos type three hypermobility type where people can... you can't see me here, but my fingers can bend backwards. But it's, it basically it's very, very common, and those people tend to have increased sympathetic activity naturally. [00:24:39] Lindsey Dinneen: Fascinating. [00:24:39] Andrew Holman: So yeah, so we're, we're waking up a little bit to some very important features here of individuals that may help us do better with the diseases they also come in. [00:24:50] Lindsey Dinneen: Yeah. Wow. [00:24:52] Andrew Holman: Sorry, long answer. Sorry, but there's a lot. [00:24:54] Lindsey Dinneen: No, that's great. I appreciate it, and yeah, well, then there you go. Managing stress is critical to, to your health. It's not just a nice to have, like yeah, yeah, kind of thing. Okay. Whew. [00:25:07] Andrew Holman: Good learning. [00:25:08] Lindsey Dinneen: Okay, awesome. Yeah, so, I'm curious... Okay, so, so again, I like, I like looking at guests' LinkedIn profiles and, and learning more about, you know, what makes you tick outside of your career as well, and I noticed some very fun things that you have listed. So we've got creative writing, horsemanship, golf, and vintage passenger rail cars. I feel like this warrants... [00:25:33] Andrew Holman: Yeah, it's called... Yeah, the American Association of Private Railcar Owners. Yeah. I get ribbed a lot for that, but they're a great bunch. There are about --I don't know if I know all the numbers now, but about 75 to 80 vintage cars from the '20s, '30s, '40s, '50s, who tag on the back of Amtrak, and Amtrak drags them around, and you can actually go rent them, stay in them, whatever. And they have a a annual meeting where they just get on a private train, and they go on tracks that you wouldn't go on naturally, like private rails in the, you know, middle of nowhere. So that's what they like to do. And it's just a lot of fun, especially the dome cars. [00:26:12] Lindsey Dinneen: Okay. That's so cool. [00:26:14] Andrew Holman: I've been a handful of times. I've got a lot of friends there. I don't own a car, but boy, I'd sure like to have one. [00:26:19] Lindsey Dinneen: Yeah. Okay. That is so cool. And then how about horsemanship? How did you... Have you been riding horses your whole life, or how did that come about? [00:26:29] Andrew Holman: So I went to a high school called Thatcher School in Ojai, California, where there are 50 in a class, and there was a requirement, this is over 100 years old, this school, that you had to have a horse. And they would say s- that something about the "outside of a horse is good for the inside of a boy," right? I was the last all-male class in 1977. Now young women get to go there too. It's of note that I have 15 people from Thatcher investing as family and friends in, Inmedix. So, th-they that, that's pretty special. But it's a boarding school. I was there for four years. My dad had gone there, so I'd heard of it. But I got a tremendous education. Th-there aren't a lot of prep schools on the West Coast, but there are some. And, and that's where I learned how to ride a horse like riding a bicycle. My sister is a thoroughbred horse trainer for 40 years. She's retired. She had three or four or five horses, a har-- not the fancy kind of stuff at the Derby. But they, you know, get up at 4:00 a.m. and ride, you know, that kind of... Tough life, but she loved horses. So yeah, I, I'm as, I'm more comfortable on a horse than I am around anything, probably. [00:27:34] Lindsey Dinneen: That's so cool. Okay. Well, this has been really fun to, to get to hear your incredible life story so far, and I'm excited to see where the company continues to advance medical technology. So, you know, I really appreciate everything you're doing. But I do want to ask, is there a moment that stands out to you along your career path so far where you just thought, "Wow, I am in the right industry at the right time"? [00:28:02] Andrew Holman: Yeah, I'd, I'd say there probably was. When we unblinded the prospective double-blind study that we did looking at this five-minute next generation heart rate variability, this HRV we got through the FDA last year. When we unblinded the study, and although that's not part of the FDA clearance, it was a very important moment for me because it showed that it predicted a year in advance who would respond to treatment of rheumatoid arthritis with ninety percent sensitivity, ninety-five percent specificity. So I wanna emphasize that is not what it's cleared for. It's cleared as an HRV tool that doctors can use at their discretion. But that study is what you asked me to answer. And when you unlock a study and you see the results, two things happen. One is we were happy that I was on the right track. That was nice. You know, positive study. Your hypothesis is valid. But it completely changed the view of immunology, [00:28:58] Lindsey Dinneen: Hmm. [00:28:59] Andrew Holman: Because we would have a test now that could measure the autonomic nervous system with exquisite precision. Nobody cared except me. About 10 years ago, we were waiting for better biologics, the things on TV, right? They asked, "Ask your doctor if it's good for you." Nobody realizes that they work about twenty-five percent of the time in terms of disease control. That's a big gap, but it looks like it's the brain that monitors inflammation. The inflammation the immune system is not firewalled against everything. The brain c-controls it, and it's not the endocrine so much with cortisol, it's the autonomic that works in milliseconds that, that epinephrine response. So that's a... You know, you're pretty nervous when you un-- when you-- someone tells you, "Okay, here is the results." [00:29:48] Lindsey Dinneen: Yeah. Wow. [00:29:50] Andrew Holman: And, and, and that was it. And then it turned out in 2015, the other moment was when I was going through the airport at Seattle and I saw the cover of of Scientific American, Bioelectric Medicine, Setpoint Medical's vagus nerve stimulation, hacking the the vagus nerve to fix the autonomic nervous system to reduce the burden of rheumatoid arthritis. I go, "Okay, now it's time." We had the patent on it. Okay. Ten years forward, we're where we are now. We're launching in June, and we have a software juggernaut here and a literally a vital sign. So, th-the doctors decide what to do with this, but we've put it in their hands, and it's paid for by insurance. So yeah. [00:30:34] Lindsey Dinneen: Amazing. Well, that's, that's so cool. Congratulations on that. That's fantastic. Okay, so to pivot the conversation a little bit just for fun, [00:30:43] Andrew Holman: Hmm? [00:30:43] Lindsey Dinneen: imagine that you were to be offered a million dollars to teach a master class on anything you want. What would you choose to teach? [00:30:53] Andrew Holman: Well, I, I learned that you've all had professors that didn't probably know as much as they should about a subject, but they thought it was just fun. I would probably stick with what I know. So I would do a master class on fibromyalgia because you can actually treat it. And there's published data, but it's very-- it's not widely known. We will be using Inmedix and autonomic testing to do research to validate and get that problem finally solved and put to bed. And then the other is this thing called immunoautonomics. It, the term-- I made up the term 15 years ago. It's in the medical literature. So that's what I would teach. Teach what I know. [00:31:27] Lindsey Dinneen: I love that. Okay, excellent. And how do you wish to be remembered after you leave this world? [00:31:34] Andrew Holman: Well, I, you know, it all come... I define myself by what the patients, how they do and what they say. It's not about five stars and all that, you know, you know, there's plenty of those. But it's, it's... I made a, a commitment if somebody says anything about me, I made a commitment when I was a rheumatologist with all these mostly young women upset, that I would never leave the room with them crying. Didn't matter how far behind I was, didn't matter. We went through a lot of Kleenex. There's a l- it's devastating to get these diseases when you're a young woman. And they can put that on my tombstone, not to dismiss people. We had a saying in the office, "It's gotta be something." You know? It's, it's always something. Drives me crazy when doctors will say, "Oh, that's nothing." Well, well, first of all, we know it's not nothing. It, it is always something, and there's something that defines your success, and there has to be things that define your failure. So let's figure out what the something is, but let's not argue that there's nothing there. So let's not dismiss people who are frightened and worried, and maybe they don't tell the story as clearly as we'd hope. But you know what? It's not, it's not their fault. They're in distress. It's amazing what people are like after you help them with their chronic pain. [00:32:45] Lindsey Dinneen: Yeah. Yeah. That is really cool and makes so much sense. Yeah. Thank you. Okay, and then final question: what is one thing that makes you smile every time you see or think about it? [00:32:59] Andrew Holman: It's making me smile right now. When I talk to the young fellows that are in their training and they're finishing up, so they've done three years or four years of medicine, three years of internal medicine after that, and then they do three or two, three, four years of rheumatology, and then they're gonna go out, I tell them how jealous I am of what they're gonna see. The, the last, the last 40 years we had these young men mostly coming in with terrible weight loss and immune systems, falling apart, and these strange tumors, and they're dying of, of infections like yeast and candida that, you know, everybody did fine with, and it was HIV, right? It had to be figured out. Now HIV is a chronic disease. It's like diabetes. We had so many people die in the '80s. Hepatitis C was... You'd have liver enzymes up, and it wasn't hepatitis A 'cause we could test for that, and it wasn't hepatitis B 'cause we could test for that. So we just called it non-A, non-B. Literally, that's what we called it. And then that got to be called hepatitis C, right? 'Cause it was too embarrassing to call it n- what it wasn't. And now hepatitis C is curable with antiviral agents in, like, three weeks. I mean... And then the biologics showed up. They're not perfect, but they were a big step. And then this immunoautonomics and, and understanding how pain and sleep and the autonomic nervous system work. I'm just really jealous of what those young clinicians are gonna get to see. [00:34:27] Lindsey Dinneen: Yeah. Yeah, that's really... Yeah, I can see why. But it sounds like you are, you know, keeping, keeping your what, what would they say? Like, toe in the water or something so that you're able to, to watch some of this as well and be a part of that next [00:34:40] Andrew Holman: I feel like I'm a ne- I feel like I'm neck deep and I'm just hoping I don't go down any lower. [00:34:47] Lindsey Dinneen: Fair enough. [00:34:48] Andrew Holman: 'Cause I have to find a way to pay for it. [00:34:50] Lindsey Dinneen: Oh, yeah, yeah, yeah. The details, you know. Yeah, yeah. [00:34:53] Andrew Holman: You got those details, yeah. [00:34:54] Lindsey Dinneen: Yeah. Oh my gosh. Well, this has been an incredible conversation. I really appreciate your time today and sharing your insights and, and stories and, yeah, I'm so excited to see the future of medicine, and I appreciate perspectives of, like yours, where you just, you share a lot of hope and optimism, and you're actively working to change lives for a better world. So, thank you. [00:35:16] Andrew Holman: Yeah, I, I irritate a lot of people with that optimism, but I'm sorry, it's just there. I can't fix it. [00:35:22] Lindsey Dinneen: Brilliant. Well, I love it. It makes my heart happy, so thank you so much again, and I hope you have the best rest of your day. [00:35:31] Andrew Holman: Thank you so much. Thanks for having me. [00:35:32] Lindsey Dinneen: Of course. [00:35:34] Dan Purvis: The Leading Difference is brought to you by Velentium Medical. Velentium Medical is a full service CDMO, serving medtech clients worldwide to securely design, manufacture, and test class two and class three medical devices. Velentium Medical's four units include research and development-- pairing electronic and mechanical design, embedded firmware, mobile app development, and cloud systems with the human factor studies and systems engineering necessary to streamline medical device regulatory approval; contract manufacturing-- building medical products at the prototype, clinical, and commercial levels in the US, as well as in low cost regions in 1345 certified and FDA registered Class VII clean rooms; cybersecurity-- generating the 12 cybersecurity design artifacts required for FDA submission; and automated test systems, assuring that every device produced is exactly the same as the device that was approved. Visit VelentiumMedical.com to explore how we can work together to change lives for a better world.

A Nobel Prize-winning discovery from 1931 described a cellular “fermentation switch” tied to cancer. That same switch shows up — in a much milder form — in millions of exhausted, foggy, always-cold people who've never had the right tests run.TLDR: Fatigue that sleep doesn't fix. Brain fog. Always cold. Muscle heaviness. Crashing after a workout. These aren't personality traits or “just aging”; they're often signs that your mitochondria, the tiny power plants inside every cell, aren't running the way they should. In this episode, I walk through:* What mitochondria actually do (in plain English)* The 6 physical warning signs your body sends when they're struggling* The 5 lab markers that reveal mitochondrial stress — most of which your standard panel isn't interpreting correctly* Why your body's pH and proton gradient might be the most underrated marker you've never heard of* 8 ways to start rebuilding mitochondrial function this week, starting todayWhat Mitochondria Actually Are (In Plain English)This is a very rudimentary explanation…Every one of your roughly 37 trillion cells contains tiny structures called mitochondria. Their job is to take the food you eat and the oxygen you breathe and convert them into a usable form of energy called ATP (adenosine triphosphate).Think of it like currency exchange. Food is your paycheck. But you can't pay your bills with a paycheck directly. You have to convert it into cash first. That's what mitochondria do. Your heart, brain, and liver cells are packed with hundreds to thousands of them, because those organs demand the most energy.So the real question is: what happens when those mitochondria get damaged?The Warburg Connection And What It Actually Tells UsIn 1931, German biochemist Otto Warburg won the Nobel Prize in Physiology or Medicine for his work on cellular respiration. Part of what made him famous was an earlier observation: many cancer cells generate energy primarily through fermentation (a process called aerobic glycolysis) rather than through the oxygen-based process healthy cells typically rely on - even when plenty of oxygen is available. Warburg's Nobel Prize was officially awarded for his discovery of the respiratory enzyme, and part of what he demonstrated along the way was that cancerous cells can live and develop even in the absence of oxygen. This pattern is now known as the Warburg effect.Here's where I want to be careful, because this is the kind of claim that's easy to oversimplify. It's tempting to say “damaged mitochondria cause cancer,” full stop. The real picture is messier and still debated. Researchers have gone back and forth for decades on whether this metabolic shift is a cause of cancer or a consequence of it, and more importantly, later research found that in most cancers, the mitochondria aren't actually broken. Subsequent research has shown that mitochondrial function is not impaired in most cancer cells, even though those cells still preferentially ferment glucose. The “why” behind that switch remains one of the more actively studied questions in cancer metabolism.So what does this mean for you, a person who almost certainly doesn't have cancer but does feel exhausted all the time? It means the fermentation-under-stress pattern Warburg first described is a real, well-documented phenomenon in cell biology, but I'm not going to tell you that your fatigue is “pre-cancer” or that a milder version of the Warburg effect is definitively what's causing your brain fog. What the broader mitochondrial dysfunction research does support is more modest and, frankly, more useful: when mitochondria are chronically stressed by poor diet, chronic stress, poor sleep, toxin exposure, or simply aging, cells generate less usable energy and more oxidative byproducts, and that shows up in the body long before it shows up on a standard lab panel.The Physical Warning Signs Most Doctors MissI hear a version of this sentence constantly: “My doctor ran labs and everything came back normal.” I believe them - the numbers usually do fall within standard reference ranges. But standard panels weren't built to catch mitochondrial strain. The body, on the other hand, tends to tell you well before a lab does. As you read this list, take honest mental inventory:* Brain fog and poor concentration. Your brain uses roughly 20% of your total energy output despite being about 2% of your body weight, so when brain-cell mitochondria underperform, mental clarity is often the first thing to go.* Fatigue that sleep doesn't fix. Not “I'm tired,” but “I slept eight hours, and I'm still exhausted.” This is one of the most common complaints I hear in practice.* Always feeling cold, or a low body temperature. Body heat is a byproduct of mitochondrial activity, so a consistently low waking temperature (roughly below 97.8°F) can point to a slower metabolic rate.* Muscle weakness or heaviness without a clear cause. Muscle cells are mitochondria-dense and need constant energy for contraction.* Exercise intolerance. You work out, and instead of feeling good afterward, you're wiped out for days without properly recovering.* Sensitivity to light or sound. Sensory processing is energy-expensive, and when cellular energy runs low, the nervous system loses some of its buffering capacity.None of these symptoms are proof of mitochondrial dysfunction on their own; fatigue and brain fog have a long list of possible causes, from thyroid issues to iron deficiency to depression to sleep apnea, and a thorough workup should rule those out first. But if several of these are chronic and unexplained, mitochondrial strain deserves a place on the list.The Lab Markers That Tell the Real StoryThese are markers you can request from a standard blood draw, though a few need to be ordered specifically. I want to flag something important up front: the “optimal” ranges I use in my own practice are tighter than the standard reference range most labs will flag as normal. That's intentional. A value can sit inside the reference range and still not be where I'd want to see it for someone chasing energy and longevity, rather than just ruling out overt disease. That distinction matters, and it's worth discussing with your own physician rather than self-diagnosing off a lab printout.* Fasting insulin. Most labs allow up to 25 µIU/mL as “normal.” I typically look for something closer to 2–5. Insulin creeping up into the high single digits or beyond can be an early sign that cells are struggling to use glucose efficiently.* Fasting glucose. Optimal is generally lower than most people assume, closer to 72–85 mg/dL rather than the upper 90s that many labs will still call normal.* High-sensitivity CRP (hs-CRP). This measures systemic inflammation. Levels of CRP less than 1 mg/L are generally considered low cardiovascular risk, 1 to 3 mg/L moderate risk, and above 3 mg/L elevated risk. Damaged mitochondria leak more free radicals, and that oxidative debris is one of several things that can trigger this kind of low-grade inflammatory signal.* CO2 (bicarbonate). Part of a standard basic metabolic panel, usually reported somewhere in the low-to-high 20s (mEq/L). When it trends toward the lower end, it can be a signal of mild metabolic acidosis; worth flagging and discussing with your doctor rather than a red-alert finding on its own.* Lactate-to-pyruvate ratio. This is a more advanced, specialist-ordered marker. Normally pyruvate flows into the mitochondria and gets converted into usable energy; when mitochondrial function is impaired, pyruvate backs up and converts to lactate instead. It's worth being precise here about what the actual research supports: a lactate-to-pyruvate ratio above 20 has been shown to distinguish patients with primary mitochondrial disease from those with other conditions in clinical studies, and this marker's best-documented use is in diagnosing rare inherited mitochondrial disorders or evaluating critically ill patients not as a general screening tool for everyday fatigue. If you're curious about your own ratio, this is a conversation to have with a clinician who can interpret it in the context of your full picture, not something to self-order and self-interpret.The Proton Gradient: Why pH Might Be an Underrated MarkerHere's a mental picture that helped this concept click for me: imagine Niagara Falls. Water crashes from a height, and that force turns a turbine that generates electricity at the base. Mitochondria do something similar, except instead of water, they're moving protons (hydrogen ions) across a membrane, building up a pressure gradient. When those protons flow back through a molecular structure called ATP synthase, that “turbine” spins and produces ATP.Now imagine you lower the height of the falls. Less force, less electricity. That's roughly what happens when your body's internal environment shifts toward acidity; the proton gradient shrinks, and energy production slows with it.Blood pH is tightly regulated and normally stays between 7.35 and 7.45, it doesn't swing wildly, and if you ever see it trend outside that narrow range on a lab, that's a signal your body's buffering systems are genuinely taxed, not a subtle wellness finding. Because blood pH is so tightly controlled and hard to use as an early, everyday signal, a more practical (though far less precise) proxy some practitioners use is first-morning urine pH, tested with an inexpensive strip. Consistently low first-morning urine pH is sometimes used as a rough indicator that the body is buffering more acid overnight than ideal; though it's a screening tool at best, not a diagnostic one, and it can be influenced by diet, hydration, and other unrelated factors.A quick, honest aside on “structured water.” You may hear claims - including sometimes in wellness spaces I respect - that water inside your cells exists in a special “fourth phase” or “exclusion zone” structure that's central to mitochondrial function, an idea popularized by bioengineer Gerald Pollack. I want to be straight with you about where this stands scientifically: it's a genuinely contested hypothesis, not a fact. Independent researchers have proposed alternative physical explanations for the phenomena Pollack describes, and some of his specific claims - like light-driven charge separation in water - are considered difficult to reconcile with basic physical chemistry. The underlying biology of cellular hydration and mitochondrial function is real and important; the specific “structured water” framework is an interesting but unproven idea layered on top of it, and I don't want to present it to you as settled science.8 Ways to Rebuild Mitochondrial Function (Mitochondrial Biogenesis)The good news is that mitochondria aren't fixed in number or function. Your body can build new ones; a process researchers call mitochondrial biogenesis. Here are eight inputs that support it, roughly in the order I'd actually prioritize them with a patient. Notice that supplements are last, not first.* Morning sunlight. Getting outside within about 30 minutes of waking supports circadian alignment, which in turn supports metabolic function.* Zone 2 cardio. This is exercise intensity where you can still hold a conversation roughly 3–4 sessions per week, 30–45 minutes. It's popularly described as uniquely effective for mitochondrial biogenesis through a signaling pathway called PGC-1α. I want to add a fair caveat here: while Zone 2 has been widely positioned in popular media as the optimal intensity for improving mitochondrial and fatty-acid oxidative capacity, a 2025 narrative review found the evidence for that specific claim is more mixed than commonly portrayed, and some research suggests higher-intensity training activates these same pathways just as strongly, if not more so. Zone 2 is still a well-supported, low-risk, sustainable way to build an aerobic base; I just don't want to oversell it as the only path to mitochondrial adaptation.* Cold exposure. This is a stressor, so I don't recommend starting here if you haven't built a foundation first. In animal studies, chronic cold exposure increases expression of mitochondrial proteins and the master regulator of mitochondrial biogenesis, PGC-1α, in brown adipose tissue - human data on the same mechanism is still developing. However, functional brown fat has been confirmed to exist and activate with cold exposure in adult humans. If you're adapted to it, starting with 30–60 seconds at the end of a shower is a reasonable entry point.* Circadian alignment. Consistent sleep/wake timing supports the same systems that morning light and cold exposure influence.* Structured hydration. Beyond simply drinking more water, this includes grounding and infrared light exposure - inputs that (independent of the more speculative “structured water” claims above) are reasonably tied to circadian and metabolic health.* Metabolic flexibility. This is your body's ability to switch between burning glucose and burning fat for fuel. Time-restricted eating is one of the more accessible tools for improving this, but it's a second-phase intervention, not a starting point, especially if your body isn't metabolically ready for it yet.* Red and near-infrared light therapy. Red to near-infrared light is absorbed by cytochrome c oxidase, an enzyme in the mitochondrial electron transport chain, and this interaction is associated with increased ATP synthesis by mitochondria. Most of the research uses roughly 10–20 minutes of targeted exposure, often over the head and torso.* Mitochondrial cofactors. This is where most people want to start and where I'd ask you to start last. CoQ10, magnesium, and B vitamins (especially B1, B2, B3) function as electron carriers within the Krebs cycle, and alpha-lipoic acid is a mitochondria-specific antioxidant. On top of these, I use Nion to support the body's pH and hydration balance, and Protandim NrF2 to help address the oxidative load that builds up when mitochondria are already under stress, but these work best layered on top of the lifestyle inputs above, not as a substitute for them.Quick Reference: What the Markers MeanThese "optimal" figures reflect the ranges I personally use with patients pursuing proactive metabolic health, not universal diagnostic cutoffs. Always interpret your own labs with a clinician who has your full history.This Week's ProtocolThree simple steps, none of which should cost much or take more than a few minutes a day:* Tomorrow morning: get outside within 30 minutes of waking for a few minutes of natural light.* Pick up pH test strips (inexpensive, available almost anywhere) and test your first-morning urine for three consecutive days. Write the numbers down.* Pull your last basic metabolic panel and find your CO2/bicarbonate value. If you don't have a recent one, get one drawn.Where to Go From HereIf you recognized yourself in several of the symptoms above, the first move isn't panic - it's data. We walk through exactly this kind of cellular assessment with patients every week inside the Thrive 120 framework. If you want a professional to look at your labs and symptom picture and tell you the top three things to address first: Disclaimer: this article is educational, not medical advice. Talk to your doctor before making changes to your diet, exercise routine, or supplement regimen, especially if you're pregnant, nursing, on blood thinners, or managing a chronic condition — including cancer. Some links below are affiliate links — if you buy through them, I may earn a commission at no extra cost to you. These statements have not been evaluated by the FDA, and none of these products are intended to diagnose, treat, cure, or prevent any disease.)References* Nobel Prize in Physiology or Medicine 1931 — Otto Warburg, biographical: https://www.nobelprize.org/prizes/medicine/1931/warburg/biographical/* Warburg effect(s) — a biographical sketch of Otto Warburg and his impacts on tumor metabolism — PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784299/* Warburg Effect — a Consequence or the Cause of Carcinogenesis? — J Cancer: https://www.jcancer.org/v07p0817.htm* Genome-Scale Metabolic Modeling: mitochondrial function is not impaired in most cancer cells — PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053319/* C-Reactive Protein and cardiovascular risk categories — Circulation (AHA): https://www.ahajournals.org/doi/10.1161/01.cir.0000093381.57779.67* Clinical usefulness of hs-CRP across Framingham risk scores — Circulation (AHA): https://www.ahajournals.org/doi/10.1161/01.cir.0000125690.80303.a8* Diagnostic values of lactate-to-pyruvate ratio in mitochondrial disease — PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC9334250/* Lactate and lactate:pyruvate ratio in pediatric acute liver failure — PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5328928/* Mitochondrial dysfunction and ischemia in critical illness (lactate:pyruvate ratio) — PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470667/* Much Ado About Zone 2: A Narrative Review — PubMed: https://pubmed.ncbi.nlm.nih.gov/40560504/* Chronic cold exposure induces mitochondrial biogenesis in brown adipose tissue — iScience: https://www.cell.com/iscience/fulltext/S2589-0042(21)00402-8* Effect of habitual cold exposure on brown adipose tissue activity — systematic review: https://www.tandfonline.com/doi/full/10.1080/22423982.2025.2545059* Photobiomodulation of cytochrome c oxidase by chronic transcranial laser — PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC8971717/* Brain Photobiomodulation Therapy: A Narrative Review — PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC6041198/* Exclusion Zone Phenomena in Water — A Critical Review of Experimental Findings and Theories: https://arxiv.org/pdf/1909.06822Links mentioned:* Metabolic Blueprint Session: https://calendly.com/tripleplaydoc/complimentary-consult * Nion: https://www.nionhealth.com/tripleplaydoc* Protandim NrF2: https://tripleplaydoc.lifevantage.com/us-en/shop/protandim-nrf2 This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit tripleplaydoc.substack.com/subscribe

Heather joins the show to talk about growing up in Framingham, we talk about her mom being our CCD teacher and how she's doing, we talk about her travels through NH and Hawaii, we talk about her journey to Idaho with her husband Wayne, we talk about how she's started in her amazing weight and heatlh journey, how she is thriving in her role in coaching and helping otherrs acheive their goals and much, much more!!

Send us Fan MailLooking for a Vermont summer getaway filled with outdoor adventure, mountain golf, great food and time with friends? In this episode of the Ski Moms Podcast, Nicole and Sarah trade chairlifts for golf carts during a girls' golf trip to Killington and Woodstock, Vermont (read more here).First, they explore summer at Killington Resort, including the Killington Golf Course, K-1 Gondola, mountain coaster, Soaring Eagle, spa treatments at the Killington Grand Hotel and après-golf cocktails. Then they head to picturesque Woodstock for a round at the Woodstock Country Club, lunch at the Woodstock Inn and a tour of one of Vermont's most charming mountain towns.Along the way, Nicole and Sarah discuss the surprising similarities between skiing and golf, why midweek golf is ideal for beginners, and how golf can help moms connect with teens and older kids. Whether you're planning a Vermont family vacation, girls' getaway or summer trip to a ski resort, this episode offers plenty of inspiration—and proof that you don't have to be a great golfer to have a great time.Stop by Salem, Woburn, or Framingham, and head to skihaus.com to check store hours and get exact locations. Find your perfect family-friendly mountain stay—or list your own! 

Send us Fan MailAre you giving your kids a memorable enough summer? If that question makes you feel guilty or overwhelmed, this episode is for you.Nicole welcomes back sisters, moms and Iksplor founders Kailey and Karissa for an honest conversation about summer mom guilt, raising outdoor kids and learning to embrace the season your family is actually in—not the one you planned.The conversation was inspired by a message they shared with the Iksplor community:“Some summers are big adventures. Some are sprinklers on the trampoline in the backyard. Whatever your summer looks like right now, you're doing enough.”In this episode:Letting go of summer mom guiltRaising outdoor kids without forcing big adventuresWhy Nicole rejects the “18 summers” mentalityLow-effort ways to get children outsideBalancing motherhood and entrepreneurshipNew products and sustainable initiatives at IksplorWhy you—and the summer you're creating—are enoughKailey and Karissa first joined us in February 2024 to share the Iksplor founder story and explain why merino wool is ideal for active families.→ Listen to their first Ski Moms Podcast episode→ Learn more about IksplorIf this message resonates, share the episode with another mom who needs to hear it.Don't miss the Annual Tent Sale, happening August 7th through 9th at the Woburn store only. The sale kicks off Friday at 5 p.m. and continues all weekend, just in time for Massachusetts Tax-Free Weekend.Stop by Salem, Woburn, or Framingham, and head to skihaus.com to check store hours and get exact locations. Register by August 15, 2026, and use code SKIMOMSRETREAT to save $100 on your trip.Visit www.theskimoms.co/events to see the 2027 lineup and reserve your spot. Get the best gear recommendations and trip-planning tips directly to your inbox. Head to skimom.substack.com to subscribe. Join for free—or upgrade for all the premium perks. Premium subscriptions start at just $5 a month and get to listen ad-free and unlock exclusive content, including insider travel guides, packing lists and more. Support the showKeep up with the Latest from the Ski Moms!Website: www.theskimoms.coSki Moms Discount Page: https://www.theskimoms.co/discountsSki Moms Ski Rental HomesJoin the 13,000+ Ski Moms Facebook GroupInstagram: https://www.instagram.com/theskimoms/Send us an email and let us know what guests and topics you'd like to hear next! Sarah@skimomsfun.comNicole@skimomsfun.com

Send us Fan MailSeason 6 begins with one of my favorite conversations yet.This week, I'm joined by a favorite travel partner—my daughter, Chiara.At 21 years old, she's old enough to look back on a childhood filled with ski racing, family ski trips, endless weekends in the mountains, and now our annual mother-daughter adventures exploring America's national parks.Like so many moms, I've spent years packing the car, replacing outgrown ski boots, planning trips, and wondering if my kids would someday appreciate all the effort that goes into creating these experiences.In this conversation, I finally get my answer.We talk about what it was really like growing up skiing, the lessons ski racing taught her about resilience and hard work, and why she still chooses to travel with me as a young adult. We also share highlights from our recent trip to Acadia National Park, including favorite hikes, biking the famous carriage roads, where we stayed, and the small traditions that make our adventures so memorable. And this is the bag we mention.If you're spending your weekends driving to ski races, hauling gear, convincing little legs to keep hiking, or wondering whether all this effort is making a difference, I hope this conversation reminds you that it is.The memories you're creating today don't end when your kids turn 18.Don't miss the Annual Tent Sale, happening August 7th through 9th at the Woburn store only. The sale kicks off Friday at 5 p.m. and continues all weekend, just in time for Massachusetts Tax-Free Weekend.Stop by Salem, Woburn, or Framingham, and head to skihaus.com to check store hours and get exact locations. Register by August 15, 2026, and use code SKIMOMSRETREAT to save $100 on your trip.Visit www.theskimoms.co/events to see the 2027 lineup and reserve your spot. Get the best gear recommendations and trip-planning tips directly to your inbox. Head to skimom.substack.com to subscribe. Join for free—or upgrade for all the premium perks. Premium subscriptions start at just $5 a month and get to listen ad-free and unlock exclusive content, including insider travel guides, packing lists and more. Support the showKeep up with the Latest from the Ski Moms!Website: www.theskimoms.coSki Moms Discount Page: https://www.theskimoms.co/discountsSki Moms Ski Rental HomesJoin the 13,000+ Ski Moms Facebook GroupInstagram: https://www.instagram.com/theskimoms/Send us an email and let us know what guests and topics you'd like to hear next! Sarah@skimomsfun.comNicole@skimomsfun.com

(00:00 - 2:56) It's Tuesday! Astronomers have detected a type of sugar in space that's also found in raspberries and self-tanners. The sugar, called erythrulose, lurks in what's called the interstellar medium: thin clouds of gas and dust littered between stars.(2:56 - 9:04) Today's DM Disaster is from Nikki! She was in a rush when she was leaving the salon; it was also raining cats and dogs! Well, she had too much in her hands and ended up dropping her only key fob into the sewer drain. Then she had to pay a good chunk of money to replace the fob! That's Nikki's DM Disaster! (9:04 - 16:09) "Coastal Grandma" is still one of the biggest lifestyle trends, think linen shirts, comfy sweaters, beach walks, Nancy Meyers kitchens, Ina Garten recipes, and looking effortlessly elegant. Adam, however, has accidentally invented Suburban Grandfather.(16:09 - 19:44) Today's Supah Smaht player is Eric from Framingham! Find out if they were Supah Smaht! (19:44 - 22:55) Men online were asked what instantly makes a woman more attractive, and the answers weren't about looks, they were about capability (22:55 - 28:14) In a strange incident, an elephant killed two people 14 years after killing two other members of the same family. The shocking part? The family had relocated 10 miles away, and the beast still managed to find them. All this and more on the ROR Morning Show with LBF & Adam 12 Podcast. Find more great podcasts at bPodStudios.com…The Place To Be For Podcast Discovery! Follow us on our socialsInstagram - @rormorningshowFacebook - The ROR Morning ShowSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your brain is not broken, it's doing what it was designed to do: panic over vivid, rare threats and ignore the slow, familiar ones. That's the risk perception gap, and it's why a headline about hantavirus can feel more urgent than the everyday drivers of cardiovascular disease, even though heart disease remains a top killer worldwide. We get candid about how fear gets “calibrated” online, why viral health content often misses the point, and how to stop stepping over dollars to pick up pennies.We walk through the real-world risk factors that actually move the needle: high LDL cholesterol, high blood pressure, uncontrolled blood sugar, smoking, sedentary living, excess alcohol, low fiber intake, and diets heavy in saturated fat and ultra-processed foods. Then we make the stats feel human. Using a Framingham-style risk score and a simple projection exercise, we explain how “25% risk in 10 years” changes when it becomes “a one in four chance you miss the trip you've been dreaming about” or “you're not there for the moments that matter.”You'll also hear a string of common examples where people fear the wrong thing, from microwaving plastic while eating processed, saturated-fat-heavy meals, to worrying about medication side effects while underestimating the risks of untreated obesity, sleep apnea, hypertension, and type 2 diabetes. We close with why clinicians need a voice online, how lifestyle medicine helps cut through misinformation, and how to prioritize the essentials before chasing accessory “health hacks.” If this helped you rethink your risk radar, subscribe, share it with a friend who needs it, and leave a quick review.Go check out my website for tons of free resources on how to transition towards a healthier diet and lifestyle.You can download my free plant-based recipes eBook and a ton of other free resources by visiting  the Digital Downloads tab of my website at https://www.plantbaseddrjules.com/shopDon't forget to check out my blog at https://www.plantbaseddrjules.com/blog You can also watch my educational videos on YouTube at https://www.youtube.com/channel/UCMpkQRXb7G-StAotV0dmahQCheck out my upcoming live events and free eCourse, where you'll learn more about how to create delicious plant-based recipes: https://www.plantbaseddrjules.com/Go follow me on social media by visiting my Facebook page and Instagram accountshttps://www.facebook.com/plantbaseddrjuleshttps://www.instagram.com/plantbased_dr_jules/Last but not least, the best way to show your support and to help me spread my message is to subscribe to my podcast and to leave a 5 star review on Apple and Spotify!Thanks so much!Peace, love, plants!Dr. Jules 

Let's Discover the Best Cities in Brazil for Gay RetireesMost Americans think of retirement abroad and immediately picture Portugal, Spain, Mexico, or maybe Thailand.But if those feel too expensive, too far away, or just not quite right, Brazil deserves a serious look for your gay retirement dollar.Brazil offers something rare: warm weather, lower costs, strong LGBTQ+ legal protections, major queer visibility, Afro-Brazilian culture, beaches, food, music, private healthcare, visa options, and, yes, many, many, many Speedos.In this episode of Queer Money, we're continuing our Affordable International Gay City series with the 5 best gay cities in Brazil for gay retirees.Brazil is not Nordic order. It is not Mexican expat familiarity. It is not Portuguese calm, even though Portuguese is the language, which, yes, you should start learning before you move. But Brazil may offer gay retirees a powerful mix of affordability, culture, LGBTQ+ acceptance, and lifestyle that can make retirement abroad feel much more possible.We compare each Brazilian city to Framingham, Massachusetts, our U.S. touchstone city for this episode, and look at what matters for gay retirement abroad: cost of living, average two-bedroom rent, LGBTQ+ visibility, state and city acceptance, queer nightlife, healthcare access, safety, lifestyle, and overall retirement fit.This week, we cover Belo Horizonte, Curitiba, Salvador, Florianópolis, and São Paulo.Takeaways from this episode:Why Brazil deserves a serious look for gay retirement abroadWhy Brazil's LGBTQ+ protections and public acceptance rank stronger than many people assumeHow Brazilian cities compare with Framingham, Massachusetts, for cost of livingWhy Belo Horizonte may work for retirees who want Brazil without São Paulo intensity or beach-city chaosWhy Curitiba may appeal to gay retirees who want structure, affordability, healthcare, parks, and practical city livingWhy Salvador may be especially compelling for Black gay retirees seeking Afro-Brazilian culture and visibilityWhy Florianópolis offers beaches, nature, wellness vibes, and a relaxed queer-friendly lifestyleWhy São Paulo takes the top spot as Brazil's queer mega cityWhy Portuguese, safety planning, neighborhood choice, and local research matter before movingWhy the question is not “Is Brazil right for every gay retiree?” but “Which Brazil fits the retirement lifestyle I actually want?”Brazil may not be right for everyone. If you want perfect predictability, spotless bureaucracy, or a country that runs like a Swiss train schedule, Brazil may test your spirit.But if you want warmth, affordability, legal residency options, strong LGBTQ+ protections, private healthcare, culture, food, music, and cities with real queer life, Brazil may deserve a spot on your retirement abroad shortlist.Before you make any move, research it, visit for longer than a vacation, and run the numbers for your actual life. This is a lot easier with a plan of action and that's exactly why we created the Queer Money Retire Abroad Planner and Calculator. Chapters:00:00 - Intro02:57 - Belo Horizonte05:11 - Curitiba09:00 - Salvador11:22 - Florianópolis14:55 - São Paulo18:50 - OutroMentioned in this episode:What if your portfolio came with a visa and passport?That's exactly what the Optimize Portugal Golden Opportunities Fund can do, bringing together diversification, tax efficiency, and a path to EU residency and a passport. Click the link below to explore your ticket to Europe.Get Your Portugal Golden Visa Here!Portugal is calling. Will you answer?Don't just dream of moving to Portugal, make it happen with the investments in your IRA. Investing in Portugal gets you residency, the ability to work in Portugal and returns that just may outpace the U.S. like the Optimize Portugal Golden Opportunities fund did in 2025. Get Your Portugal Golden Visa Here!

Welcome to The Turf Zone podcast. This episode features a Q & A spotlighting NE-SFMA Sports Field Manager of the Year Chris McGinty – Superintendent of Parks Maintenance Division for the City of Framingham, Massachusetts. Read from the Summer 2026 issue of New England Blade magazine. Where did your turf management education begin? I received a B.S. in Outdoor Recreation and Environmental Studies at Springfield College, followed by Forestry at University of New Hampshire, and I have a Certificate of Sports Turf Management from the University of Georgia. How did you get your start in sports field management? I began with the Massachusetts State Parks System and then took a position with the Town of Framingham as the Superintendent of Parks and Cemeteries in 1991. During my 35 years in Framingham, my job has evolved from Park Properties to all Sports Facility and Grounds for the city. What do you like best about your current position? The ability to provide the best experiences for the many different users of city-owned recreational facilities in our community. What is the biggest change you've seen in the sports field industry? The use of technology for so many aspects of our jobs including irrigation, lighting, and the introduction of robotics. Who are your mentors in the sports field management profession? Former Groundskeeper Skip Vigarolo in Belmont, MA; Ron Morrel at MDC Golf Courses; Bob Leblanc at Boston College; and Mary Owen of UMass. What is the best business advice you've ever received? Being able to accept that in the municipal arena, others can, and will, take credit for all the hard work you have put into a project or event. What is the next game-changer you see on the horizon for the sports field industry? The expanded use of robotics and improved synthetic turf surfaces. What's your favorite / most useful: Equipment? Chainsaw and Zamboni Product? Toro Machines Technology? Musco Control Lighting What advice would you share with people starting out in sports field management today? Enhance your career path and increase your knowledge with as many licenses and certifications as possible (i.e., CSFM, hoisting, CDL, pesticide applicator). Any industry-related volunteer service? In addition to my tenure on the NE-SFMA board of Directors, I am head of the Landscape Program Advisory Board at Keefe Tech Vocational High School and run an annual Arbor Day of Service event in the City of Framingham. Can you share a bit about your family and what you enjoy doing in your free time? Maryann and I have been married since 1989. We have two children: a son who is a police detective in Framingham, and a daughter who works in Human Resources. In my free time I try to play a lot of golf, travel, read, and work on old vehicles – muscle cars and antiques. What have you found most beneficial about being a NE-SFMA member? When I started, I had very little sports turf knowledge and I went to many seminars, programs, and talks on the subject. When I joined the NE-SFMA, I began to interact with a lot of different people in our industry. This is when I realized that there were so many people in our organization who have diverse talents and are willing to share ideas and advice at any point. I credit my interaction with different board members through the years as helping me make a successful career here in the City of Framingham. The post Member Spotlight on Chris McGinty appeared first on The Turf Zone.

WBZ NewsRadio’s James Rojas reports.See omnystudio.com/listener for privacy information.

Primary stroke prevention is a critical opportunity for neurologists, with most stroke risk driven by modifiable factors such as hypertension and lifestyle behaviors. This episode highlights practical tools and strategies, including Life's Essential 8 and contemporary risk calculators, while also exploring evolving approaches to shared decision making and secondary prevention. In this episode, Katie Grouse, MD, FAAN, speaks with Mitchell S. Elkind, MD, MS, FAAN, author of the article "Stroke Prevention" in the Continuum® June 2026 Cerebrovascular Disease issue. Dr. Grouse is a Continuum® Audio interviewer and a clinical assistant professor at the University of California, San Francisco in San Francisco, California. Dr. Elkind is the Chief Science Officer for Brain Health and Stroke at the American Heart Association in Dallas, Texas, and a professor of neurology and epidemiology at Columbia University in New York, New York. Additional Resources Read the article: Stroke Prevention Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Guest: @MitchElkind Full episode transcript available here Dr Grouse: Neurologists have generally been more involved in secondary stroke prevention, but primary stroke prevention is increasingly recognized as an important topic of discussion for neurologists. Today, I have the opportunity to interview Dr. Mitchell Elkind, who wrote the article on stroke prevention in the newest Continuum issue on cerebrovascular disease.  Dr Jones: This is Dr. Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast.  Dr Grouse: This is Dr. Katie Grouse. Today, I'm interviewing Dr. Mitchell Elkind about his article on stroke prevention. This article appears in the June 2026 Continuum issue on cerebrovascular disease. Welcome to the podcast, and please introduce yourself to the audience.  Dr Elkind: Thank you so much, Katie. So, my name is Mitch Elkind, and I'm the Chief Science Officer for Brain Health and Stroke at the American Heart Association and a stroke neurologist by background.  Dr Grouse: Well, I just want to start by saying that I really enjoyed reading this article. I think this is just a really wonderful article I recommend strongly. Such a high yield, an important topic for a lot of us who see patients who are interested in learning about their stroke risks or need help with, uh, stroke prevention after having a stroke. So, I wanted to start. What's changed in the last couple of years? You know, what are some big highlights that you really want to stress that are different from maybe the last time we reviewed this topic?  Dr Elkind: Sure. Well, there's been a lot of development in the field of secondary stroke prevention, for one thing. But even beyond that, I think we increasingly appreciate how important it is to control what we call the social drivers of health on the earlier side, primordial or primary prevention. And that has been a big advance, I'd say. And I would also say, I think it's really important for neurologists to understand some of those questions about primordial and primary prevention. You know, we tend to get involved with patients after they've had a stroke or maybe a TIA, some kind of event. But sometimes we find people who are following for, you know, non-stroke related conditions who have risk factors also. And we can really play an important role in identifying those risk factors and helping to prevent a first stroke or vascular event as well. So, I think it's real important for us to be doctors even before we're neurologists. So, you know, Katie, about ninety percent of stroke risk is modifiable, so we can do a great job as neurologists in preventing stroke. And one of the most important things that we can do is to identify and treat high blood pressure. And recently, actually, the American Heart Association, American College of Cardiology guidelines on the management of hypertension have said that treatment of high blood pressure not only prevents stroke, but it can also help to prevent cognitive decline and dementia. And this is the first time that we've had a class of recommendation one and level of evidence A, the highest level of recommendation we give for the use of blood pressure treatment to prevent dementia. And that's largely based on the results of some large trials that have come out recently showing that you can prevent dementia with blood pressure control. So that's a really exciting link, I think, between cardiovascular risk factor control and subsequent brain health. It just illustrates the role that neurologists can play in, so many conditions outside of stroke as well.  Dr Grouse: That's a really great point, and I want to get a little more into the idea of primordial stroke prevention. Can you tell us a little bit more about what that might be?  Dr Elkind: So primordial prevention refers to addressing how we can prevent risk factors from occurring in the first place, and how can we improve the environments in which people live. You know, we know that only about twenty percent of health outcomes is dependent on what happens between the patient and their doctor in the office. About eighty percent of it is due to what happens in the environments in which we live, work, pray, and play. And so that's what we mean when we refer to the social drivers of health. What is the neighborhood like where somebody lives? Do they have access to healthy food? Do they have places where they can go to exercise? Is there air pollution in the area that may affect their health? You know, one really interesting fact that's become apparent in the last few years is that air pollution is a major risk factor for stroke. Something like a sixth of all strokes can be attributed to the quality of air. And so, what are the things we can do at the broader public policy, community level to reduce the risk of risk factors like high blood pressure and diabetes even before somebody has an event that brings them to the attention of the doctor? So that's what we're thinking about with regard to primordial prevention. It's the earliest stage in prevention.  Dr Grouse: And that's really fascinating. You know, I think an area that we haven't, as neurologists, really put a lot of our time thinking about, but clearly a very important thing. I really appreciated reading your article about how you incorporated the fact that, you know, a lot of these risk factors overlap very, very closely with all the risk factors for various types of cardiovascular events. And I would imagine that the work you've done as the Chief Clinical Science Officer for the American Heart Association has informed a lot of the way you've thought about-Trying to bring all these risks together and think a little bit more holistically about the whole thing. Could you tell us a little bit more about that and the work that you've done on the American Heart Association's Life's Essential 8 score?  Dr Elkind: Sure. I can't take credit for it. It's really work that was done by others at the Heart Association, particularly a cardiologist and epidemiologist named Don Lloyd-Jones. But many other volunteers participated. Life's Essential 8 is our approach to primary stroke prevention and cardiovascular prevention more broadly. We say Life's Essential 8 because it includes four health behaviors and four health factors that people can observe to reduce their risk of cardiovascular disease. The four factors are kind of things like know your numbers, your blood pressure, your blood sugar, your body mass index, right, which is a combination of weight and height, and your cholesterol level. So, know those numbers and keep them within the recommended ranges, and talk to your doctor if they're not. And then four lifestyle behaviors. So, one of them is to eat a healthy diet, and typically that means the Mediterranean diet. It means getting regular exercise, and we recommend 150 minutes a week of moderate to vigorous physical activity. Of course, it means abstinence from smoking or other tobacco products. And the last one, the eighth one, which I was so excited about when we added this, is sleep, recommending at least seven hours of sleep a night. So, I was really excited about this because we used to talk about Life's Simple 7, and then the last iteration of our recommendations included this recommendation for adequate sleep because of the mounting evidence of the importance of sleep to cardiovascular health. But sleep is really a brain function, right? And so, it was really the first, in a way, specific brain function that was added to our recommendations. So that's Life's Essential 8. People can read about it online at heart.org and recommend it to your patients as a simple way for people to understand the best approach to reducing their risk of cardiovascular disease, including stroke.  Dr Grouse: I checked it out myself after reading the article. It's very accessible to patients. It's a great education tool. And they can, you know, see their own score and use that in their own way to, to think about what their risks are and how they can help mitigate and then rescore themselves down the line. There's also, though, on the kind of more the clinician side, the PREVENT calculator as well. Could you tell us a little bit more about how we could use that in approaching this patient population?  Dr Elkind: Yeah. So, I think of Life's Essential 8 as being a patient-focused tool that people can use. PREVENT is really more for clinicians. Anybody can look it up online and enter your data into it. There's a risk calculator online. But the basic idea behind PREVENT and other similar risk calculators is that it's a way to estimate somebody's risk of having a cardiovascular event like stroke or a heart attack or even heart failure by entering information about your health. And we used to think, we used to use something called the ASCVD, atherosclerotic cardiovascular disease risk calculator, or the Framingham score. Framingham Heart Score, for example, was another one. PREVENT is the latest version, and it has several advantages over those earlier types of risk predictors. For one thing, it predicts risk at younger ages as well. It goes down to age 30. It predicts risk over a longer duration of time, so over 30, 10 or 30 years. It eliminates the use of race as an item to put into the calculator and substitutes for that socioeconomic status, so it's not a race base, but a measure of social disadvantage. And it also includes kidney elements, kidney measures. It includes renal function, for example, that weren't included in prior measures, and it can also be used to predict heart failure, which was not part of the original calculators. Another major advantage of the PREVENT study is that it was based on real-world data from about three million patients, many, many more than the 50,000 or so that the earlier risk calculators were based on. So, it has a much more robust data set and therefore allows a bit more precision in the ability to predict future risk of events. And typically, primary care doctors would enter their patient's data, calculate a risk, and then based on the results of the risk calculator, they can make recommendations about what type of medications a person should take or what other strategies they could use to reduce their risk. And so that's the role that PREVENT plays, is really being focused more for the clinician than the patient.  Dr Grouse: Really great tool for us to be aware of. You earlier alluded to the fact that neurologists are in the situation where we sometimes are helping patients with this primary prevention. But you also make a case for why it's in the patient's best interest for us to be involved in, in these conversations when we can, when we have the opportunity. Can you tell us more about that?  Dr Elkind: Shared decision-making is really important because we know that people aren't going to lead the healthiest possible lives if they're not invested in their care. And so, a doctor telling somebody what to do if the patient doesn't want to do it is gonna have limited benefit.So we emphasize the importance of shared decision-making as much as possible. And I think that where this comes up a lot is actually in the situation of, for example, atrial fibrillation, where patients will often be put on a blood thinner. And many people are fearful of blood thinners. They worry about the risk of bleeding. Maybe they know a relative who's had a bleeding complication from a blood thinner, and so they may be disinclined to try it. And so, it's really important to have these discussions about the risks and the benefits of medication and engage the patient in thinking about this. And there are even tools and visual aids that people can look to to help explain some of these complicated concepts to patients. So, these are the kinds of things that reflect implementation science as a way to improve adherence. We know what works in a clinical trial setting often, but the challenge is translating that into the real world and getting our patients to use the medications that we believe scientifically have been shown to be of benefit. I've actually been surprised sometimes at conversations I've had with people, in some cases, healthcare professionals who resist going on blood thinners because of their fear of the complications. And I feel like the evidence is there. Why don't they believe me? And that's why it's really important to have the conversation. Even our peers and colleagues can sometimes question the evidence, and it's important for us to be aware of that.  Dr Grouse: Absolutely. I think that sounds very reasonable to me, and hopefully these tools will help us with making some of these decisions with our patients. Now, turning our attention a little bit to secondary prevention. So, you know, someone's already had a stroke or a TIA, sort of thinking about what we can do to optimize their risk factors for further strokes. You know, I think there has been some changes that have happened, I think, in the last few years that might be affecting some of the decisions we're making and some of the advice we're giving our patients. I wanted to talk a little bit about GLP-1 receptor agonist medications. Is the data there to support use of this either in secondary prevention or even in primary prevention in the case of stroke?  Dr Elkind: There is evidence that supports the use of GLP-1s for stroke prevention. We need more data, though. We need trials that focus only on patients with stroke, for example, there have been studies in patients with cardiovascular disease broadly that include stroke patients. But if you look at the subcategory just of stroke patients alone, the data in that subgroup alone don't always show a benefit. And so, we need more data that's focused on stroke patients alone. So, I think the data are continuing to emerge, but we need more still.  Dr Grouse: Is there any development in the thought about whether we should be putting patients on antiplatelet therapies for incidental, incidentally identified strokes? For instance, if you got an MRI for migraine or for other reasons and you found one, no history of any stroke-like symptoms. Should we be putting these patients on aspirin or any other types of therapies?  Dr Elkind: That's a really great question. And again, it's an area where there's some controversy and really, there's really no definitive data that would support using antiplatelet therapy in people with incidentally discovered infarcts or what we call, you know, whispering strokes or silent strokes. Many stroke neurologists will use antiplatelet agents. This is one of those areas where it's so important to identify the risk factors. As we were saying before, patients who have other neurological disorders like migraine or epilepsy may turn out to have cardiovascular risk factors like diabetes and high blood pressure. That's why it's so important for neurologists to be able to treat those patients or refer them to specialists who can. Patients who have incidentally discovered lesions similarly are a group where we should be looking for risk factors. So, I don't think of it only in terms of do we put them on an antiplatelet or not, but really more holistically, can we identify their other risk factors and address those? Should the patient's information be entered into a risk calculator like PREVENT, for example, so that we can come up with a more global or holistic measure of their cardiovascular risk and address that as appropriate? Because if they are at risk for stroke, they're also at risk for cardiac events, including heart attack, heart failure, sudden cardiac arrest, and so forth. So, I think of it as a, as a great kind of teachable moment or an opportunity to catch somebody and bring them into the healthcare system more broadly and address those other potential risk factors.  Dr Grouse: Speaking of, of risk factors that we often like to think about and work up when possible, in cases where it seems certainly possible the patient had an embolic stroke, but perhaps we've done a few weeks or four weeks of cardiac monitoring, have not found any evidence of atrial fibrillation. What's new and what's the current recommendations for doing further monitoring when there's high suspicion for cardioembolic stroke?  Dr Elkind: This is a really active area of investigation, and guidelines suggest that we should do some cardiac monitoring for atrial fibrillation after an unexplained stroke, but it's not clear how much we should do. Studies generally show that the longer you follow somebody on a cardiac monitor after stroke, the more likely you are to detect atrial fibrillation. It could be as high as thirty percent after a few years. And that's great. And if you detect atrial fibrillation, people usually end up being recommended for a blood thinner. But how extensively we should monitor remains unknown. And I think a lot of the investigation recently has been around the question of, are there other ways to get that information rather than waiting six months or a year for the person to develop atrial fibrillation?It's a little bit funny logically to think a person has a stroke today, a year later you discover atrial fibrillation on the monitor, and you say, "Oh, now I know what caused your stroke a year ago." Right? The temporality, the causality perhaps is off in that case. And so, wouldn't it be better if we could tell what somebody's risk of having another cardioembolic stroke is, or the likelihood that they have atrial fibrillation is at the time that you first see them for the stroke, you know, in the hospital, for example. And so, there's some really new technologies that have evolved like AI or artificial intelligence interpretation of EKGs that can give a really good indication of which people are gonna go on to develop atrial fibrillation. And so, I think we need some more trials in that area to demonstrate that we can detect the risk of AFib and treat that even before it appears on one of those delayed monitors. That's an area that I think is very exciting right now. There's also a further question with regard to how to treat these patients, which is that sometimes atrial fibrillation is a consequence of the stroke itself. So, we can think about what people call known AF, meaning atrial fibrillation that's known about before the stroke even occurs, versus AF that's detected after a stroke, or AF-DAS, people will say. Those may have very different implications for the risk of recurrence and what the person's cardiovascular status is. So, I think what we've learned over the last few years is that atrial fibrillation, it used to be like the slam dunk for a stroke neurologist. It was the easy thing. You know, you had a stroke, you have AFib, you should be on a blood thinner. Now we know that there's lots of different kinds of AFib. There's AFib before stroke, there's AFib after stroke, there's burden of atrial fibrillation. So, some people may have 30 seconds of AFib, some people may have several hours, some people may be in it continuously. It comes and goes, and that can make it challenging to manage. So, we have a lot more work to do to understand this problem better.  Dr Grouse: That also gets me into some other interesting areas that I think there's still some question, you know, how aggressive should you be? How often is it a case of is this correlated or is this causative? For instance, when a patent foramen ovale is, is discovered in patients with cryptogenic stroke. Are there any tools or new developments to help us understand whether these PFOs should be closed in these cases?  Dr Elkind: PFO and stroke is a great story that's been going on for decades. And again, we've made tremendous progress in the last several years. So, it's true that about 20% or so of people have a PFO, and because of that, it can be really hard to say with any certainty whether an individual patient sitting in front of you, that the PFO was the cause of their stroke. Rarely we can have a really high degree of certainty. You know, if somebody has, uh, a DVT, for example, and shortly after that maybe they have pulmonary embolism and then a stroke, and we can say, "Oh, clearly this was a paradoxical embolism," went to the lungs and then some crossed over and went to the brain. That happens really infrequently. Most of the time you're faced with a patient who has a PFO and a stroke, and they may have some other risk factors. There are some tools that we can use to help figure out the likelihood that a PFO is related to a stroke. One of those is called the ROPE score or the risk of paradoxical embolism score that was developed by David Thaler and, uh, David Kent from Tufts and a group of other investigators as well. That score allows one to say what the likelihood is that the PFO was causative of the stroke, and it's based on a person's risk factors such that the younger you are, the more likely it is the PFO caused the stroke. And the absence of risk factors make it more likely that the PFO caused the stroke. So, the higher your ROPE score indicating the fewer other reasons you have a stroke, the more likely the PFO is to be causative. So that can be helpful in identifying patients who may have had a stroke due to their PFO. There are other features that are identified in something called the PASCAL score, which is a way of assessing the degree of shunting and whether or not there's an atrial septal aneurysm that can be used as additional factors that lead to the likelihood that a PFO was causative rather than just incidental. So, by putting this kind of information together, we can kind of do precision neurology or precision prevention by identifying which patients with a PFO are really the ones we need to worry about and do procedures like closure.  Dr Grouse: I look forward to hearing more and learning more as more advances are made in these areas. Dr Elkind: Thank you.   Dr Grouse: And thank you so much for joining us today to talk about your article.   Dr Elkind: Oh, I appreciate it. Thank you for giving me the opportunity. I really enjoyed it.  Dr Grouse: Again, today I've been interviewing Dr. Mitchell Elkind about his article on stroke prevention. This article appears in the June 2026 Continuum issue on cerebrovascular disease. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining today.  Dr Monteith: This is Dr. Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

WBZ NewsRadio’s Jay Willett reports.See omnystudio.com/listener for privacy information.

Send us Fan MailIn this episode, the Ski Moms welcome Kristin Hurd and Karen Musgrave, Canadian ski instructors and co-creators of the Divine ARCS Affirmation Cards, a 31-card deck designed to help skiers connect with the mental and emotional side of the sport. Based at Silver Star Mountain Resort in Vernon, B.C., Kristin (originally from Australia, CSIA Level 4) and Karen (from Southern California, who became an instructor at 40 and earned her Level 3) met during their certification journey and have been collaborating ever since.The conversation covers their CSIA certification paths, their new "Divine Arc Ski Experience" camps for women, their Kids Mountain Magic book, and practical mindful skiing tips, including Karen's "Superman pose" for overcoming fear. They also share a full destination guide to Silver Star, from travel logistics and lodging to dining, kids' programming, and après ski in the Okanagan Valley.Resources:Divine ARCS Affirmation Cards: https://divinearcs.comSilver Star Mountain Resort: https://www.skisilverstar.comBook Lessons at Silver Star: Visit the Silver Star website lessons page or email the ski school to request Kristin Hurd or Karen Musgrave (specify last name "M" for Karen)Key Quotes:"Breathe in my strength, breathe out the fear. Just coming back into my breath. When I get out of my own way and come into the present moment, my skiing gets way better." — Karen Musgrave"The snow is your canvas — paint your picture." — Karen MusgraveThe Patio Place and Ski Haus helps you make the most of outdoor living. Stop by Salem, Woburn, or Framingham, and head to skihaus.com  Check out the gift guide here Opening June 20, Portillo Chile is one of the most iconic ski destinations in the world—gorgeous, uncrowded, and incredibly easy for families since everything's right on-site.Ski Moms listeners get 10% off stays from June 20 to August 1.Email reservations@skiportillo.com and mention SKIMOMS. Celebrate your love of the laid-back ski life. Shop cozy gear made for the mellow skier: 

WBZ NewsRadio's Shari Small has more.See omnystudio.com/listener for privacy information.

This week's forecast is looking a bit gloomy, with showers and clouds rolling in, but the city is gearing up for a different kind of excitement - the World Cup. The speaker discusses the latest news and updates, from the Patriots to the Red Sox, and even some exciting announcements in the music world.This episode covers a range of topics, from sports to local news and entertainment. The speaker touches on the ongoing scandal involving the Patriots, the latest developments in the NBA and NHL playoffs, and the Red Sox's impressive win against the Braves. We also hear about some local news, including the cancellation of Fourth of July fireworks in Framingham and the school bus drivers' strike in Marlborough.The speaker also shares some fun updates, like the musical lineup for the 250th anniversary in DC and the new Oreo flavor inspired by BTS. And, of course, no sports update would be complete without a mention of the World Cup, including the city's efforts to accommodate fans and the slow pace of FIFA's permitting process.If you want to hear more about the latest news and updates from the world of sports and beyond, tune in to this episode to hear the rest of the conversation.See omnystudio.com/listener for privacy information.

Send us Fan MailHow omega-3 fats in human health, including dietary intake needs, supplements, & omega fat testing.TOPICS DISCUSSED:ω-3 chemistry: EPA and DHA differ from plant ALA in chain length and double-bond count, making them structurally and biologically distinct — and largely irreplaceable by ALA conversion.ALA-to-EPA/DHA conversion: A small percentage of dietary ALA converts to EPA, and conversion to DHA is even lower; vegans rely on this inefficient pathway for all long-chain omega-3s.Cardiovascular mechanisms: ω-3s lower triglycerides, reduce platelet stickiness, improve endothelial function, and slow resting heart rate, reducing cardiovascular risk.ω-3 Index: Defined as red blood cell EPA+DHA as a percent of total fatty acids; 8–12% is the target range, while most Americans sit around 4–5%.Brain & dementia risk: Higher DHA blood levels are associated with significantly lower risk of dementia and Alzheimer's in large cohorts including the UK Biobank and Framingham.Linoleic acid nuance: Higher blood levels of dietary linoleic acid (omega-6) associate with lower dementia and cardiovascular risk; downstream omega-6 metabolites — not linoleic acid itself — associate with adverse outcomes.Supplementation practicalities: Most people need 1–2 g/day of EPA+DHA to reach an ω-3 Index >8%; oxidation concerns with fish oil supplements may be overstated.ABOUT THE GUEST: Bill Harris, PhD is founder of both OmegaQuant Laboratory and the Fatty Acid Research Institute (Sioux Falls, SD), where his work centers on blood fatty acid biomarkers as predictors of disease risk in large population cohort studies.KNOW YOURSELF:OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.RELATED EPISODE:M&M 134: Omega Fats, Vegetable & Seed Oils, Sugar, Processed Food, Metabolic Health & Dietary Origins of Chronic Inflammatory DiSupport the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.For all the ways you can support my efforts

WBZ NewsRadio's Emma Friedman has more.See omnystudio.com/listener for privacy information.

Send us Fan MailThis episode will cover a fascinating and little known period in the art history of Paris as told in the book titled: "The Club - Where American Women Artists Found Refuge in Belle Époque Paris". I will interview Jennifer Dasal, author of the book, who will share fascinating highlights. You will learn about what was essentially a boarding house in Paris that supported a generation of independent American women artists as early as 1893 for a number of decades. These women were a broad mixture of artists - in all fields of artistic talents - painters, sculptors, etc. The "Club" allowed them the opportunity to interact with other famous and established artists like Mary Cassatt and Auguste Rodin. I was interested in "The Club", since my book, the biography of miniature portrait artist, Amalia Kussner - covered a similar time period. And there was indeed some interesting overlap in content between the two books - such as with sculptor Auguste Rodin.Note: Some of the works of the impressive sculptor, Meta Vaux Warrick Fuller, who is discussed in this episode, can be seen at the Danforth Museum, in Framingham, MA.Jennifer's Website link is here or www.jenniferdasal.com. If you are interested in ordering her book - you can use this link from her website.My website link is here or www.kathleenlangone.com. The biography, The Miniature Painter Revealed: Amalia Kussner's Gilded Age Pursuit of Fame and Fortune, is available at all major book outlets such Barnes and Noble, Amazon with links at the website. Feel free to connect with me using the Contact page at that website.Social Media:Facebook: Kathleen Langone AuthorInstagram: @phihpodSubstack: @kathleenlangone and title: Gilded Age HistoryBluesky: @phihpod.bsky.social

WBZ NewsRadio's Jay Willett reports. See omnystudio.com/listener for privacy information.

WBZ NewsRadio’s Jared Brosnan reports.See omnystudio.com/listener for privacy information.

Jon Marshall is the head football coach and athletic director at Randolph High School, where he has transformed the Blue Devils into one of the top high school football programs in Massachusetts. A Marine Corps veteran, educator, and culture-builder, Marshall is widely respected for his leadership both on and off the field. Since taking over the program in 2018, Marshall has led Randolph to historic success, including the school's first-ever state championship in 2021 and multiple Super Bowl appearances. Under his leadership, the Blue Devils have developed a reputation for toughness, discipline, and a dominant rushing attack, while also emphasizing academic excellence—famously noting that a large portion of his team regularly earns honor roll recognition. Marshall's coaching philosophy is rooted in accountability and effort, captured in his program's mantra: “Winners do more.” That mindset has helped turn Randolph into a perennial contender and a model program built on character and consistency. Before arriving at Randolph, Marshall served in the U.S. Marine Corps and later built his coaching résumé at programs like Framingham and Holliston, while also working as a history teacher. His military background and upbringing—heavily influenced by his father, a hardworking veteran—continue to shape his leadership style and commitment to developing young men beyond football. Marshall's impact has earned him statewide and regional recognition, including the New England Patriots High School Coach of the Year award and multiple Coach of the Week honors. Today, Jon Marshall is more than just a football coach—he's a mentor, educator, and program architect who has built Randolph football into a championship culture grounded in discipline, resilience, and pride. Learn more about your ad choices. Visit megaphone.fm/adchoices

(00:00 - 4:58) It's FRIDAY! We talked about the return of Artemis 2; Bob is amazed that all the astronauts like each other after being isolated for 10 days. (4:58 - 11:05) Today's DM Disaster is from Anna! She needed to use the bathroom, but she was with her 4-year-old son. She had to bring him in the with her, then her son decided to yell out loud "mommy why is your willy fuzzy" she was mortified! Then she had to completely bail out of the store because of the embarrassment. That's Anna's DM Disaster! (11:05 - 19:56) Are you smarter than your parents! Bob and LBF say no; they're not. But what is considered being smarter? We dive into this with both feet! (19:56 - 24:35) Today's Supah Smaht player is Hedi from Framingham! Find out if they were Supah Smaht! (24:35 - 30:03) A woman from New England did the unthinkable, she rowed across the Atlantic and became the oldest woman to do so! Her name is Renee Blacken! (30:03 - 36:16) Bathhouses are on the rise; Bob is all on board with this trend same with LBF! We also talked about some of the local bathhouses you should be taking advantage of! All this and more on the ROR Morning Show with Bob and LBF Podcast. Find more great podcasts at bPodStudios.com…The Place To Be For Podcast Discovery! Follow us on our socialsInstagram - @bobandlbfFacebook - The ROR Morning ShowSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Adam Urato, Chief of Maternal-Fetal Medicine at MetroWest Medical Center, spent decades on the front lines of obstetric care before he couldn't ignore what the data was showing. In this episode, he walks Drs. May and Tim through the rise and fall of Makena — a drug prescribed to prevent preterm birth that was ultimately pulled by the FDA in 2023 after being proven ineffective — and connects it to a larger pattern of flawed trials, minimized risks, and industry-driven guidelines that have shaped standard obstetric care for years. Dr. Urato then turns to SSRIs, now taken by roughly 1 in 10 pregnant women. He breaks down what the research actually shows about how these drugs cross the placenta, disrupt fetal serotonin pathways, and may impact long-term brain development in children — findings that rarely make it into the exam room conversation. He also addresses the fierce pushback from major medical organizations after an FDA advisory panel hearing, and why he believes the response had more to do with protecting a narrative than protecting patients. The throughline: informed consent is broken in obstetrics, and fixing it starts with physicians being willing to say the uncomfortable things out loud. GUEST BIO Dr. Adam Urato is the Chief of Maternal-Fetal Medicine at MetroWest Medical Center in Framingham, Massachusetts — the same hospital where he was born. A Harvard Medical School graduate with nearly 30 years of experience caring for high-risk pregnancies, Dr. Urato has become one of medicine's most outspoken voices on pharmaceutical safety in obstetrics. He has testified before the FDA, written and lectured extensively on antidepressant use during pregnancy, and played a key role in exposing the failures of Makena. His free course, Antidepressants and Pregnancy, is available through Mad in America. CONNECT WITH DR. URATO Mad in America course: madinamerica.com Follow on X: @AdamUrato1 CONNECT WITH US Thanks for joining us — you are the reason we are here. Have questions? Reach out at doc@bsfreemd.com or find Tim and May on Facebook and Instagram.

Zeyneb Magavi is a bona fide climate nerd; she drives an electric car, has solar panels on her roof, and worries about natural gas leaks because they're a major source of planet-warming emissions. Bill Akley is a lifelong natural gas guy; he grew up smelling heating oil in his kitchen, spent decades in the energy industry, and eventually became head of New England's largest gas utility.  So what brought this improbable duo together? The answer is under your feet. In this episode, how a geothermal pilot project in Massachusetts is bringing together unlikely alliances that might be key to our clean energy future. Featuring Zeyneb Magavi, Bill Akley, and Kevin Kircher. Produced by Felix Poon. For full credits and transcript, visit outsideinradio.org. SUPPORT Outside/In is made possible with listener support. Click here to become a sustaining member of Outside/In.  Follow Outside/In on Instagram or join our private discussion group on Facebook. LINKS Learn more about the networked geothermal pilot in Framingham, MA, and how it works.Learn more about the “gas-to-geo transition” that HEET advocates for. Learn more about your ad choices. Visit megaphone.fm/adchoices

The State of Ohio Adversity and Resilience (SOAR) project is Ohio State University College of Medicine's attempt at creating a comprehensive mental health study for Ohio's population.Researchers have collected mental health data on many counties across Ohio.What the Framingham study did for heart disease is what the SOAR project wants to do for mental health.We're discussing the issue on this hour of All Sides.Guests:Scott Langenecker, PhD, professor and vice chair of research for psychiatry and behavioral health, The Ohio State University College of MedicineAnthony King, PhD, psychologist and associate professor of psychiatry and behavioral health, The Ohio State University Wexner Medical Center/director, STAR Trauma Recovery Center and Program for ResilienceIf you have a disability and would like a transcript or other accommodation you can request an alternative format.(Photo: Alex Green / Pexels)

The State of Ohio Adversity and Resilience (SOAR) project is Ohio State University College of Medicine's attempt at creating a comprehensive mental health study for Ohio's population.Researchers have collected mental health data on many counties across Ohio.What the Framingham study did for heart disease is what the SOAR project wants to do for mental health.We're discussing the issue on this hour of All Sides.Guests:Scott Langenecker, PhD, professor and vice chair of research for psychiatry and behavioral health, The Ohio State University College of MedicineAnthony King, PhD, psychologist and associate professor of psychiatry and behavioral health, The Ohio State University Wexner Medical Center/director, STAR Trauma Recovery Center and Program for ResilienceIf you have a disability and would like a transcript or other accommodation you can request an alternative format.(Photo: Alex Green / Pexels)

全球每天有超过 2 亿人在服用他汀类药物，它是目前处方量最大的药物类别之一。其中最知名的一个，叫立普妥。立普妥的研发，在学术报告里经常被作为理性药物设计的经典案例——围绕它的研究前后诞生了四位诺贝尔奖得主，它也是人类历史上累计销售额最高的处方药之一，让辉瑞一度跻身全球最赚钱的制药企业。但这个故事，比教科书上写的要曲折得多。从第一个他汀分子在一株真菌里被发现，到立普妥成为全球最畅销的处方药，中间隔了将近 30 年，险些在好几个节点就彻底结束了。这期节目，不只是「立普妥是怎么被发现的」，而是一粒药从实验室走到全球 2 亿人手里，科学、资本与营销究竟是如何共同发挥作用的。时间轴：00:09 为什么要讲立普妥？02:16 「胆固醇假说」是怎么建立的？从兔子实验到 Framingham 心脏研究，医学界用了近半个世纪。04:46 主人公远藤章：筛遍六千株真菌，找到第一个他汀类化合物美伐...去小宇宙查看完整单集简介在小宇宙查看该单集文稿

After providing some key taper advice, we welcomed back a very special guest, Darren Sapper (Julie's husband), who has spectated the Boston Marathon ten times.Darren provides guidance on getting to the spectating spots and how to navigate Boston while with kids.We appreciate Darren's support of the podcast and our running and coaching pursuits. Thanks to Darren for joining us.Darren's coordinates for spectating spots:Mile 6.5 in Framingham: 16 Concord St, Framingham, MA 01702 (north side of the route, runner's left)Mile 13 in Wellesley: 13 Central St, Wellesley, MA 02482 (north side of the route, runner's left)Mile 20 in Newton: 638 Commonwealth Ave, Newton, MA 02459 (south side of the route, runner's right)Join us for our shakeout run in Boston on Sunday, 4/19 at 8:30 at a new location—338 Newbury Street in front of Trident Booksellers.Follow us on Instagram and Facebook Interested in hiring a coach? Email us at julieandlisa@runfartherandfaster.com or head over to our website.Please follow, share and review our show!

Send us Fan MailThe Ski Moms welcome back Kendra Scurfield (Chief Marketing Officer at Banff Sunshine Village, author, and mom) to share why spring skiing in Banff is a hidden gem for families. They explore what sets Sunshine Village apart—from its high elevation and consistent late-season snowfall to its sunny, celebratory spring atmosphere with longer days, soft snow, and lively après.The conversation covers practical planning tips, including flying into Calgary, choosing between staying in Banff or at the ski-in/ski-out Sunshine Mountain Lodge, and how to prepare for spring conditions with smart layering, extra gear for kids, hydration, and sun protection.Kendra also explains why spring is ideal for progression, with softer snow and warmer temps helping both kids and adults build confidence. They highlight family-friendly terrain, childcare and lessons starting at 18 months, and opportunities for moms to push their own skiing—from groomers to more advanced terrain.Off the slopes, they share what makes spring at Sunshine so fun, from outdoor dining and ski boot dance parties to themed weekends and the iconic Slush Cup. This episode is full of inspiration and practical advice for families looking to extend their ski season and embrace the ease and joy of spring skiing in the Canadian Rockies.Resources:Instagram: @kendrasoniawww.skibanff.comThis is also that sweet spot where the SKI HAUS deals get really good. Note: Store hours are changing due to in-store inventory going on, so check before you head over.They've got locations in Woburn & Framingham, MA and Tax-Free Salem, NH. Head to skihaus.com to check store hours and directions. Spring family fun in Ulster County:Earth Fest at the Ashokan Center/April 19Kingston Point Beach for the Hudson Valley Kite Festival /May 17, Hudson Valley Faerie Festival/May 30 For more ways to get outside together this spring, head to VisitUlsterCountyNY.com and start planning your spring getaway. If your child lives for trail time and is constantly pushing limits on two wheels, we've found the summer experience that checks every box. Woodward PA's Mountain Bike Camp is redefining what an action sports camp can be — blending epic adventure with professional coaching and a whole lot of fresh air.Ski Moms can save $150 off summer camp. Use code skimoms www.woodwardpa.com/summer-camps/moun Celebrate your love of the laid-back ski life. Shop cozy gear made for the mellow skier: 

Send us Fan MailThe Ski Moms celebrate Crystal Mountain's 70th anniversary with Karen Thor (COO, 32 years at the resort) and Brittany Primeau (Director of Communications and new mom). They explore Crystal's evolution from Buck Hills community ski area to today's master-planned four-season resort village with 1,500 acres. Karen and Brittany share their ski origin stories and discuss the family-owned Petritz legacy that created a destination where families can park once and access everything on foot or by shuttle, from ski-in/ski-out accommodations to the LEED-certified spa. The conversation covers practical planning tips including getting fitted for rentals the night before, booking lessons for ages 3 to "retired, not tired," and using the Nanny McSki program for full-day childcare on the slopes. Crystal features terrain for all levels with magic carpets, a backyard teaching area, and night skiing Tuesday through Saturday. Beyond winter, they highlight year-round activities including two championship golf courses (home to the Michigan Women's Open for 20+ years), the Crystal Coaster Alpine Slide (Michigan's only alpine slide), Michigan Legacy Art Park, and the resort's role as a base camp for exploring Northern Michigan attractions like Sleeping Bear Dunes and Traverse City.Resources:Website: www.crystalmountain.comLocation: Thompsonville, Benzie County, Northern MichigaSki Haus makes it easy with custom boot fitting that actually changes how you ski and how you feel at the end of the day.  Located in Woburn & Framingham, MA and Tax-Free Salem, NH. Head to skihaus.com for store hours and directions.SPECIAL IN-STORE OFFERS*Purchase a boot with a custom boot fit > get a free Smartwool sock  *Come in for a boot fit on your boots > get Smartwool sock for ½ price It's time to upgrade how you travel to the mountains with Ski Butlers. Ski moms can save 20% off their reservations here https://www.skibutlers.com/portal/momtrends If your child lives for trail time and is constantly pushing limits on two wheels, we've found the summer experience that checks every box. Woodward PA's Mountain Bike Camp is redefining what an action sports camp can be — blending epic adventure with professional coaching and a whole lot of fresh air.Ski Moms can save $150 off summer camp. Use code skimoms www.woodwardpa.com/summer-camps/moun Find your perfect family-friendly mountain stay—or list your own! 

Nancy Mullen, from Framingham, Massachusetts, USAHear more of Nancy's story on this week's episode of Sentinel Watch.

Send a textIn this episode, the Ski Moms sit down with Cindy Dady, CEO of Sunlight Mountain Resort in Glenwood Springs, Colorado. Cindy brings 45 years of ski industry experience — from teaching toddlers on the bunny hill to becoming the first female general manager in Colorado not serving as an owner-operator. She shares what drew her to Sunlight, why this independent mountain is a must-visit for families, and how she's leading the resort through its biggest capital investment since 1966.Cindy walks us through Sunlight's welcoming terrain (70 trails, 720 acres), its centralized and stress-free base area, and the resort's commitment to unreasonable hospitality. She also opens up about her career journey, the mentors who shaped her, and what a typical powder day looks like when you're the CEO who greets every guest at the lift.ResourcesSunlight Mountain Resort: https://www.sunlightmtn.comSunlight Ski & Bike Shop (Glenwood Springs): https://www.sunlightmtn.com/ski-bike-shopIndy Pass: https://www.indyskipass.comColorado Ski Country: https://www.coloradoski.comFly into: Eagle/Vail (EGE) – 25 min from Glenwood Springs; Aspen (ASE); Grand Junction (GJT); or Denver (DEN)Key Quotes"We provide unreasoSki Haus makes it easy with custom boot fitting that actually changes how you ski and how you feel at the end of the day.  Located in Woburn & Framingham, MA and Tax-Free Salem, NH. Head to skihaus.com for store hours and directions.SPECIAL IN-STORE OFFERS*Purchase a boot with a custom boot fit > get a free Smartwool sock  *Come in for a boot fit on your boots > get Smartwool sock for ½ price It's time to upgrade how you travel to the mountains with Ski Butlers. Ski moms can save 20% off their reservations here https://www.skibutlers.com/portal/momtrends If your child lives for trail time and is constantly pushing limits on two wheels, we've found the summer experience that checks every box. Woodward PA's Mountain Bike Camp is redefining what an action sports camp can be — blending epic adventure with professional coaching and a whole lot of fresh air.Ski Moms can save $150 off summer camp. Use code skimoms www.woodwardpa.com/summer-camps/moun Find your perfect family-friendly mountain stay—or list your own! 

Send a textKristin Ruud is the founder of Northern Classics, an outdoor clothing brand that blends timeless, elevated aesthetics with high-performance technical outerwear for kids. A University of Michigan business school graduate, Kristin's career took her through financial consulting, hedge fund management, and commercial construction before an entrepreneurial spark and three kids under one and a half during COVID led her to launch Northern Classics. In this episode, Kristin shares how she identified a gap in the children's ski apparel market: technical gear that was either purely functional or purely cute, but never both. Kristin opens up about the challenges of building a brand from scratch with no apparel background, the power of community and customer feedback, and what it's like to see her designs "in the wild" on the slopes out west. As a mom of four (twins almost 7, a 5-year-old, and a 3-year-old), Kristin brings both personal credibility and infectious joy to everything she creates.Notable Quotes:"I always say I'm selling — I am my own customer.""I try really hard to keep my kids at the forefront. I mean, they were the inspiration behind this brand."Resources:Northern Classics Website: northernclassics.comRetailers: Bloomingdale's, Nordstrom, Over the Moon, Maisonette, Janie and Jack, select REI stores, and ski shops nationwideInstagram: @NorthernClassicsSki Haus makes it easy with custom boot fitting that actually changes how you ski and how you feel at the end of the day.  Located in Woburn & Framingham, MA and Tax-Free Salem, NH. Head to skihaus.com for store hours and directions.SPECIAL IN-STORE OFFERS*Purchase a boot with a custom boot fit > get a free Smartwool sock  *Come in for a boot fit on your boots > get Smartwool sock for ½ price It's time to upgrade how you travel to the mountains with Ski Butlers. Ski moms can save 20% off their reservations here https://www.skibutlers.com/portal/momtrends If your child lives for trail time and is constantly pushing limits on two wheels, we've found the summer experience that checks every box. Woodward PA's Mountain Bike Camp is redefining what an action sports camp can be — blending epic adventure with professional coaching and a whole lot of fresh air.Ski Moms can save $150 off summer camp. Use code skimoms www.woodwardpa.com/summer-camps/moun Find your perfect family-friendly mountain stay—or list your own! 

The Framingham school district enrolled 719 fewer students compared to last school year, a "significant drop," said superintendent Bob Tremblay. While there are other factors driving the decline, the downward shift is fueled by families' fears of being detained or deported.

Send a textNicole and Sarah spent over a year planning seven days in the Dolomites for the Milan-Cortina Winter Olympics and it was 100% worth every chaotic, confusing, cowbell-confiscating moment. In this episode, they break down everything: decoding the ticket matrix, hunting down hospitality packages on two separate platforms, navigating snowy switchbacks from Venice with skis on the roof, and what it's actually like to stand in the finish area for some of the most historic women's Alpine races in recent memory.The ski racing delivered in a big way! Federica Brignone won gold on home snow to a stadium full of tiger-suited superfans. Mikaela Shiffrin closed out the women's events with a gold in the slalom that had Nicole in tears. Paula Moltzan won the second run, finished eighth, and later handed out uterus pins in the center of Cortina.Start planning earlier than you think, use miles, go with another family to split costs, and bring really good shoes. Quotes:"I think it was a complete bucket list trip of a lifetime. It was a tremendous mix of experiencing another culture in a really fun way, having intense American pride while you're there." "It was a hundred percent worth it. And we got very lucky with amazing weather, smooth travel — all those things went right."Ski Haus makes it easy with custom boot fitting that actually changes how you ski and how you feel at the end of the day.  Located in Woburn & Framingham, MA and Tax-Free Salem, NH. Head to skihaus.com for store hours and directions.SPECIAL IN-STORE OFFERS*Purchase a boot with a custom boot fit > get a free Smartwool sock  *Come in for a boot fit on your boots > get Smartwool sock for ½ price It's time to upgrade how you travel to the mountains with Ski Butlers. Ski moms can save 20% off their reservations here https://www.skibutlers.com/portal/momtrends If your child lives for trail time and is constantly pushing limits on two wheels, we've found the summer experience that checks every box. Woodward PA's Mountain Bike Camp is redefining what an action sports camp can be — blending epic adventure with professional coaching and a whole lot of fresh air.Ski Moms can save $150 off summer camp. Use code skimoms www.woodwardpa.com/summer-camps/moun Find your perfect family-friendly mountain stay—or list your own! 

Evan Marinofsky and Patrick Donnelly focus on Massachusetts postseason hockey. They review MIAA boys Division 1 seeding (Catholic Memorial No. 1, Xaverian No. 2, St. John's Prep No. 3, Arlington No. 4) and discuss potential sleepers including Reading, Wachusett, Framingham, Marshfield, Weymouth and a deep Pope Francis run, with Evan picking CM over Pope Francis in the final. They then break down MIAA girls Division 1 depth and Pat's bracket picks (Bishop Fenwick over NDA; Methuen/Tewksbury reaching the final quadrant), plus Division 2 picks highlighting Westwood, Milton, Duxbury and King Philip with Pat selecting Milton to win. The show shifts to boys prep, citing Salisbury's dominant win over Avon and changes in the Elite 8 picture, plus Avon's six-game skid. Girls prep rankings change significantly, with Nobles rising to No. 1, Loomis to No. 2, Dexter moving up, and St. Paul's surging after beating Exeter. In "Overtime," they discuss potential future Russian Olympic participation, the impact of the U.S. women's gold on women's hockey and the PWHL, and where the men's win ranks historically (both place it behind 1980). Topics 02:15 MIAA Boys D-1 Bracket 04:27 Boys D-1 Sleepers Picks 08:00 Why CM Wins D-1 11:10 Girls D-1 Wide Open 13:35 Girls D-1 Predictions 19:41 Girls D-2 Bracket Picks 26:09 Bracket Challenge Idea 26:46 Boys Prep Salisbury Surge 29:36 Avon Old Farms Slump 31:49 Avon Slump Concerns 33:12 Elite 8 Projections 35:14 Bubble Teams Watch List 39:12 Girls Rankings Shakeup 39:44 Nobles New No. 1 43:21 Loomis Surge Analysis 45:25 Dexter And St. Pauls 48:41 Top Ten Newcomers 50:43 Elite 8 Seeding Outlook 53:26 "Overtime" Olympic Questions 56:41 Women's Gold Impact 59:33 Men's Gold Memories 01:05:01 Wrap And Signoff

Send a textMegan Harrod has lived many lives, from being born in a trailer home in Montana to spending nearly a decade as the Alpine press officer for the US Ski Team, traveling the World Cup circuit and managing media for some of the world's best athletes. Now a brand strategist, publicist, and podcast producer working closely with Mikaela Shiffrin, Megan shares her remarkable journey from racing on Midwest man-made hills to the finish lines of Olympic venues. She opens up about the financial barriers in ski racing, the importance of accessibility programs like Share Winter, and how her experience managing intense athlete dynamics has made her a better mom to her two children, Pierce and Stetson, who are just 13 months apart. Megan discusses producing Mikaela's podcast "What's the Point," the powerful Mik 100 campaign that raised nearly $500,000 for ski access, and how she's learned to balance remote work with traveling to World Cup races with babies in tow. Her authentic approach to storytelling and her commitment to making the sport more accessible shine through as she reflects on memorable moments like Beijing 2022 and the importance of mental health in athletics.Notable Quotes:"I wouldn't have it any other way. It was such a cool family experience... it was such a strong community and I still have friends from that team growing up.""In many ways, that was the best thing that could have happened because people really saw who she is at the core. And as hard as it was for everyone, I think that was a really beautiful gift that she shared with the world."Resources:Podcast: What's the PointInstagram: @MeganHarrodShare Winter FoundationSki Haus makes it easy with custom boot fitting that actually changes how you ski and how you feel at the end of the day.  Located in Woburn & Framingham, MA and Tax-Free Salem, NH. Head to skihaus.com for store hours and directions.SPECIAL IN-STORE OFFERS*Purchase a boot with a custom boot fit > get a free Smartwool sock  *Come in for a boot fit on your boots > get Smartwool sock for ½ price It's time to upgrade how you travel to the mountains with Ski Butlers. Ski moms can save 20% off their reservations here https://www.skibutlers.com/portal/momtrends Find your perfect family-friendly mountain stay—or list your own! 

Evan Marinofsky and Patrick Donnelly open with reactions to the shooting at Dennis Lynch Arena in Pawtucket, R.I., offering condolences and noting reported heroes. They then preview late-season prep hockey: boys teams slipping (Avon Old Farms, Belmont Hill) and rising (Cushing, Kimball Union), and girls hockey shakeups with Phillips Andover taking No. 1, Nobles surging, plus Williston Northampton, Groton, St. Paul's and Cushing bubble scenarios. MIAA notes include Canton's Ed Burns win, Reading's defensive run, Catholic Memorial over Pope, Algonquin's perfect season, Hingham, KP, St. Mary's, and a Framingham highlight. Overtime discusses Olympic hockey. Topics 01:34 Tragedy at Dennis Lynch Arena: Community Shaken, Heroes Step Up 04:32 Pat's Ski Crash: The Collarbone Break Storytime 07:59 Back to Hockey: Playoff Stretch Run and Bracket Watch 08:34 Boys Prep: Avon Old Farms Slipping, Elite 8 Pressure Mounts 10:29 Boys Prep: Belmont Hill's Rough Patch and ISL Gauntlet 12:45 Boys Prep: Cushing's Late-Season Surge: Can It Make the Elite 8? 16:44 Boys Prep: Kimball Union Rebounds and Lakes Region Tournament Impact 20:35 Olympics-Themed Feature: "Four Nations'"All-Star Concept for Prep Hockey 23:52 Girls Prep: New No. 1; Phillips Andover Tops Williston, Elite 8 Chaos Ahead 25:28 Girls Prep: Nobles Rolling and Francie Ames' Ridiculous Scoring Streak 27:07 Girls Prep Bubble Talk: New Hampton's Turnaround and Groton's Uphill Climb 29:55 Girls Prep: St. Paul's vs Exeter Home-and-Home Could Decide the Cut Line 31:08 Girls Prep: Cushing Back in the Mix; Big Week vs Deerfield, Rivers, Dexter 33:02 Nobles vs. Andover Projections and the Race for the No. 1 Seed 34:35 Dexter's Path to Cracking the Top Four (and the Girls Standings Chaos) 35:45 MIAA Boys: Can Williston Still Sneak In? 36:36 Canton's Ed Burns Statement Win and Super 8 Talk 38:33 Reading's Shutdown Streak: Built for the Tournament 41:16 Catholic Memorial Beats Pope; CM as the Clear D-1 Favorite 42:40 MIAA Girls: Algonquin Stays Perfect with Win over NDA 44:31 Girls Contenders Heating Up: Hingham, King Philip, St. Mary's 47:23 Power Rankings, Showcases and the Shifting Super 8 Picture 49:54 Quick Hit: Framingham's Ed Cahoon Cup Win and Sleeper Potential 51:52 Overtime (Olympic Edition): Is Hockey the Best Olympic Sport? 57:23 Gold Medal vs. Stanley Cup and U.S.–Canada Final Hype (Wrap-up)

This week on Heart Doc VIP, Dr. Joel Kahn takes a deep dive into one of the most influential research projects in cardiovascular history: the Framingham Heart Study. Launched in 1948 and still going strong, this landmark study helped identify many of the risk factors we now take for granted, including smoking, diabetes, high cholesterol, high blood pressure, obesity, and physical inactivity. Much of what modern cardiology considers "common knowledge" about prevention started in Framingham. Dr. Kahn also explores practical and emerging topics in heart health, including the role of magnesium and berberine supplementation, how to approach both low-carb and low-fat diets in a healthy way, and concerns about long-term proton pump inhibitor use. Additional discussion covers EECP therapy and strategies to improve coronary blood flow, along with the potential benefits of ezetimibe for cholesterol reduction and brain health. Thank you to this week's sponsor, Igennus. Visit igennus.com and use code DRKAHN for a special discount.

We're revisiting one of our most meaningful conversations — with Olympic gold medalist, ski mom, and mental performance coach Barbara Cochran.Why now? On February 11, 1972, Barbara won Olympic gold in slalom in Sapporo by just .02 seconds. And 54 years to the day later, her son, Ryan Cochran-Siegle, won Olympic silver in Super-G in Cortina.An Olympic legacy — built on a Vermont rope tow.Barbara grew up skiing at her family's backyard hill, now known as Cochran's Ski Area — a nonprofit, community-driven mountain where lift tickets are still affordable, race training happens under the lights, and hot chocolate costs $1.50.We talk about:Growing up in a ski racing familyTraining on the legendary rope towThe “Cochran Way” philosophy of excellence without pressureRaising an Olympian as a single momAnd the mindset that wins medalsBarbara's father believed skiing should be joyful — but that striving for excellence builds character. Before sports psychology was mainstream, Barbara was practicing it. Heading into her Olympic race, she repeated:“I don't know if I'm going to win, but I know I'm capable of winning.”That mindset carried her to gold — and now informs her work helping athletes who “train better than they race” learn to compete with confidence.We also talk about the financial realities of ski racing, how Ryan nearly declined his U.S. Ski Team nomination due to cost, and Ski Haus makes it easy with custom boot fitting that actually changes how you ski and how you feel at the end of the day.  Located in Woburn & Framingham, MA and Tax-Free Salem, NH. Head to skihaus.com for store hours and directions.SPECIAL IN-STORE OFFERS*Purchase a boot with a custom boot fit > get a free Smartwool sock  *Come in for a boot fit on your boots > get Smartwool sock for ½ price It's time to upgrade how you travel to the mountains with Ski Butlers. Ski moms can save 20% off their reservations here https://www.skibutlers.com/portal/momtrends If your child lives for trail time and is constantly pushing limits on two wheels, we've found the summer experience that checks every box. Woodward PA's Mountain Bike Camp is redefining what an action sports camp can be — blending epic adventure with professional coaching and a whole lot of fresh air.Ski Moms can save $150 off summer camp. Use code skimoms www.woodwardpa.com/summer-camps/moun Find your perfect family-friendly mountain stay—or list your own! 

In this episode Nicole talks with Jill Brabec, President of Nordic Combined USA, about one of the Olympics' oldest sports that still excludes women. Nordic Combined blends ski jumping and cross country skiing, requiring athletes to launch themselves down steep terrain at maximum speed, fly the length of a football field, then immediately race 5K on skinny skis. Despite being in the Olympics since 1924, women were denied entry to the 2026 Games. Jill, a Steamboat Springs ski mom turned advocate, formed a nonprofit with other parents to save the US team when funding collapsed. Her daughter Alexa trains in Norway but can't compete in the Olympics due to gender restrictions. The IOC will decide about 2030 inclusion this spring after reviewing 2026 data. Jill draws parallels to women's ski jumping, which faced identical arguments 15 years ago and is now successful. She encourages fans to watch men's Nordic Combined February 11, 17, and 19 to show viewership demand, sign the petition at nordiccombineusa.org, and follow athletes on social media. The sport features 17 World Cups for women who jump the same hills as men and train at Lake Placid, Park City, and Steamboat Springs. Families with adventurous kids can find programs starting at age 5-6 through the website.Website: nordiccombineusa.orgInstagram: @NordicCombinedUSANOTABLE QUOTES"It's really hard to see one sibling able to go to the Olympics and the other sibling not able tSki Haus makes it easy with custom boot fitting that actually changes how you ski and how you feel at the end of the day.  Located in Woburn & Framingham, MA and Tax-Free Salem, NH. Head to skihaus.com for store hours and directions.SPECIAL IN-STORE OFFERS*Purchase a boot with a custom boot fit > get a free Smartwool sock  *Come in for a boot fit on your boots > get Smartwool sock for ½ price It's time to upgrade how you travel to the mountains with Ski Butlers. Ski moms can save 20% off their reservations here https://www.skibutlers.com/portal/momtrends If your child lives for trail time and is constantly pushing limits on two wheels, we've found the summer experience that checks every box. Woodward PA's Mountain Bike Camp is redefining what an action sports camp can be — blending epic adventure with professional coaching and a whole lot of fresh air.Ski Moms can save $150 off summer camp. Use code skimoms www.woodwardpa.com/summer-camps/moun Find your perfect family-friendly mountain stay—or list your own! 

Nikki Bruno learned early in her career that debates over climate change – and how to respond – are seldom black and white. Progress comes from honest discourse and collaboration.At Eversource, where she leads the utility's thermal solutions and operational services, Nikki manages a geothermal project that has brought together environmental activists, the utility's gas infrastructure team, ratepayers, and government leaders in Framingham, Mass. The result is the first utility-led geothermal network in the country, which came online in 2024.This week on With Great Power, Nikki Bruno describes how the gas and electric utility Eversource uses geothermal energy to power 140 homes and businesses. She talks about challenges and successes of the project, how Eversource is now expanding it with Energy Department funding, and how the utility is measuring success.Credits: Hosted by Brad Langley. Produced by Mary Catherine O'Connor. Edited by Anne Bailey. Original music and engineering by Sean Marquand. Stephen Lacey is executive editor. The GridX production team includes Jenni Barber, Samantha McCabe, and Brad Langley.

In 1985, NASA chose Christa McAuliffe, a Framingham, Mass. native and high school teacher in Concord, New Hampshire, to be the first civilian to go into space.

Bradley Jay Filled In On NightSide with Dan Rea:The American Revolution was an eight-year battle, fought primarily in Lexington, Concord, and Boston. However, many outlying towns in Massachusetts played a vital role during the early conflict. Framingham, Springfield, Marshfield, and Great Barrington provided manpower and resources which ultimately led to victory. Learn more as Bradley talked with Bob Allison, Professor of History at Suffolk University. See omnystudio.com/listener for privacy information.

Subscribe to the video podcast: https://www.youtube.com/@LiveHolPlus/Cardiovascular disease is still the number one killer, yet guidelines keep pushing cholesterol lower and more people are put on statins for life. In this hol+ episode, Dr. Taz sits down with worlds leading nitric oxide researcher Dr. Nathan S. Bryan to ask hard questions about statin risk versus benefit, why cholesterol alone does not explain heart disease, and what is nitric oxide actually doing inside the body long before a heart attack or stroke. Together, they explore why low or no nitric oxide may be the missing piece behind rising blood pressure, plaque, and dementia, even in people who “follow the rules.”From the benefits of nitric oxide for blood flow, blood pressure, diabetes, and brain health to the surprising impact of antiseptic mouthwash and antacid medications, this conversation reframes cardiovascular and metabolic disease as problems of cell signaling, not just lab numbers. You will learn what nitric oxide is, what does nitric oxide do for the body, why nitric oxide importance is often ignored in standard care, and how to raise nitric oxide through lifestyle, targeted support, and emerging restorative therapies based on decades of nitric oxide research.Dr. Taz and Dr. Bryan discuss:New cholesterol guidelines, statins, and rethinking risk vs benefitWhat is nitric oxide and what does nitric oxide do for the bodyWhy low or no nitric oxide shows up decades before heart attacks and strokeThe benefits of nitric oxide for blood flow, blood pressure, and sexual functionNitric oxide diabetes link and why insulin resistance is often a nitric oxide problemMouthwash and nitric oxide, antacids, fluoride, and the oral microbiomeHow lifestyle, diet, movement, and nasal breathing raise nitric oxide naturallyWhy standard biomarkers are late and vascular function should be tested soonerNitric oxide importance in Alzheimer's, dementia, and brain blood flowHow to raise nitric oxide safely and what to know about supplements vs “dead beets”About Dr. Nathan S. Bryan Dr. Nathan S. Bryan is a pioneering nitric oxide researcher, molecular medicine scientist, and biotech entrepreneur whose discoveries helped create a billion dollar nitric oxide market. His work has reshaped how we understand cardiovascular disease, metabolic health, nitric oxide diabetes links, and how lifestyle, mouthwash and nitric oxide, and common drugs impact long term health. He is the author of The Secret of Nitric Oxide, where he breaks down what nitric oxide is, what nitric oxide does for the body, and how to raise nitric oxide safely at home using science based tools and lifestyle shifts. Stay Connected:Connect further to Hol+ at https://holplus.co/- Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.Follow Dr. Nathan S. Bryan:  YouTube: https://www.youtube.com/@DrNathanSBryanNitricOxideInstagram: https://www.instagram.com/drnathansbryan/ Website: https://www.bryantherapeutics.com/ Product: https://n1o1.com/Get The Secret of Nitric Oxide Book here.Follow Dr. Taz on Instagram: https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Subscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsGet your copy of The Hormone Shift: Balance Your Body and Thrive Through Midlife and MenopauseHost & Production TeamHost: Dr. Taz; Produced by ClipGrowth.com (Producer: Pat Gostek)00:00 New cholesterol rules, statins, and nitric oxide importance01:00 Mouthwash and nitric oxide, blood pressure, and the oral microbiome01:46 What is nitric oxide and what does nitric oxide do for the body03:06 Why nitric oxide matters for longevity, inflammation, and aging cells04:32 Nobel Prize history and early nitric oxide research06:06 Fingerprint of nitric oxide biology and early disease markers08:13 No nitric oxide before you see plaque, blood pressure, or ED09:26 The American lifestyle and nitric oxide diabetes link10:45 Mouthwash and nitric oxide, fluoride, PPIs, and hidden blockers12:26 Statins, cholesterol guidelines, and questioning “everyone needs a statin”16:11 Cholesterol numbers, Framingham data, and what actually predicts risk19:27 Better heart screening, vascular function, and nitric oxide benefits22:28 First symptoms of low nitric oxide: ED, libido, and rising blood pressure25:04 Mouthwash and nitric oxide causation study, exercise benefits lost27:23 Antacids, reflux meds, and how they shut down nitric oxide27:58 How to raise nitric oxide naturally with food, movement, and sunlight30:19 Nasal breathing, mouth breathing, and nitric oxide delivery to the lungs31:02 Nitric oxide as a hormone and whole body signaling molecule33:18 How to measure, how to replace, and what nitric oxide testing really shows36:45 Inflammation, triglycerides, and tracking nitric oxide benefits in labs38:38 Restorative physiology vs applied pharmacology42:01 Can nitric oxide help heart failure, liver disease, and ascites44:13 Nitric oxide diabetes connection and insulin resistance46:52 Nitric oxide and Alzheimer's, brain blood flow, and “type 3 diabetes”47:57 Kids, ADHD, diet, and low nitric oxide as a blood flow problem49:08 5G, toxins, and electron flow in biochemistry51:00 Glutathione, nitric oxide transport, and why most supplements miss the mark52:18 Why arginine, citrulline, and most beet products do not fix nitric oxide55:40 Nitruticals, rebuilding nitric oxide and the oral microbiome57:32 Nitric oxide for wounds, skin, and regenerative healing59:19 Reversing disease vs managing decline, and what nitric oxide might change1:00:07 Optimizing human performance with nitric oxide as a foundation1:01:18 Where to learn more from Dr. Nathan Bryan1:01:55 Closing thoughts from Dr. Taz and hol+

Tonight on Horror Hill, host Erik Peabody invites you into an episode that defies logic, science, and perhaps even sanity itself. What begins as an innocent search for stories takes a delirious turn into the realm of the impossible—where forgotten lakes hide secrets older than the world above, and abandoned laboratories harbor creations that should never have drawn breath. In this double-feature of vintage madness, two long-buried tales rise from the depths to confront the limits of human understanding. Explorers push too far into the unknown. Scientists challenge the laws of nature itself. And when the earth finally answers, it answers with teeth. Expect the unexpected. Question everything. "The Monster of Lake Lametrie" by Wardon Allan Curtis – High in the Wyoming mountains lies a lake whispered about in old journals and frontier legends—a place where ancient things still move beneath the black water. When Professor McLennegan and his ailing companion Framingham arrive in search of scientific discovery and fresh mountain air, they instead encounter forces that defy biology, reason, and sanity. As strange upheavals churn the lake and impossible creatures rise to the surface, the professor is drawn toward an experiment that could change the boundaries of life itself. A haunting tale of obsession and awe, this story delves into the price of curiosity—and the thin line between discovery and madness. "The Day of the Dragon" by Guy Endore – Long dismissed by his colleagues and pushed to the margins of academia, Professor Paul Crabshaw dreams of vindication. His quiet resentment turns to dangerous ambition when he embarks on a secret experiment meant to revolutionize biology—but instead awakens something far older, stronger, and infinitely more terrifying than he could have imagined. As the consequences ripple outward, a lone witness recounts the bizarre chain of events that began in a dusty laboratory and spiraled into a nightmare beyond human control. A darkly comedic yet chilling exploration of scientific hubris, this tale asks what happens when myth takes flight… and the world becomes its feeding ground. To watch the podcast on YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://bit.ly/ChillingEntertainmentYT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Don't forget to subscribe to the podcast for free wherever you're listening or by using this link: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/HorrorHillPodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ If you like the show, telling a friend about it would be amazing! You can text, email, Tweet, or send this link to a friend: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/HorrorHillPodcast⁠⁠⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices