Podcasts about Molecular Psychiatry

Bien manger pour être en bonne santé… y compris dans notre tête ! Et si notre nourriture avait un impact sur notre état de santé mentale ? Ces dix dernières années, un premier lien semble émerger entre dépression et consommation d'aliments ultra-transformés par exemple. Les premiers résultats de recherches qui se multiplient grâce à un nouveau domaine de l'épidémiologie : la psychiatrie nutritionnelle. Pour en parler, nous recevons Tasnime Akbaraly, chargée de recherche Inserm à Montpellier et spécialisée en épidémiologie nutritionnelle, qui a notamment travaillé sur l'influence de l'alimentation sur les maladies chroniques et la santé mentale. Nous entendrons également Aurore bénévole au Labo des savoirs, qui va nous apprendre comment la flotte britannique à gagné des batailles navales grâce à du jus de citron. Une émission préparée et co-animée par Fabien Dézèque et Sophie Podevin, réalisée par Sophie Podevin. RESSOURCES : Healthy Eating Index (information en anglais) "Alimentation, Planète, Santé", le rapport de synthèse de la Commission EAT-Lancet de 2019 en PDF "Dietary pattern and depressive symptoms in middle age" : étude de Tasnime Akbaraly & Co de 2009 (en anglais) publié dans The British Journal of Psychiatry en PDF "Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies" : méta-analyse de Tasnime Akbaraly & Co de 2018 (en anglais) publié dans Molecular Psychiatry en PDF

In this episode, we're continuing with Part 8 of the Back to the Basics series by exploring the vital role that comprehensive lab work plays in healing anxiety and depression. I break down why we take a physiology-first—but not physiology-only—approach, the truth behind the outdated “chemical imbalance” theory, and how functional labs can uncover real root causes that are often missed in standard care.In this episode, you'll learn:Why focusing on your body is often the missing piece in mental health treatmentHow the “chemical imbalance” theory got started—and why it doesn't hold upWhat's often missing from standard lab work and how comprehensive blood testing can uncover hidden drivers of anxiety or depressionWhat markers we include in our custom lab panel and whyHow optimizing your biology creates capacity for deeper healing3 Key Takeaways:Physiology First, Not Only: There's an interplay between physiology and psychology but if your body is depleted or stressed, it changes how your brain functions. You can't mindset your way out of a nervous system stuck in survival mode.The Chemical Imbalance Theory is outdated and debunked. This oversimplified narrative can prevent people from exploring the root causes of their symptoms and keeps many stuck in medication-only treatment plans that don't fully support their healing.Comprehensive Lab Work can take out some of the guesswork. It helps uncover hidden imbalances—like nutrient deficiencies or hormone issues—that may be driving anxiety or depression. It gives you clear, personalized data to support your healing.Looking for more personalized support?Book a FREE discovery call for RESTORE, our 1:1 anxiety & depression coaching program (HSA/FSA eligible & includes comprehensive bloodwork)Join me inside Regulated Living, a mental health membership and nervous system healing space (sliding scale pricing available)Order my book, Healing Through the Vagus Nerve today!*Want me to talk about something specific on the podcast? Let me know HERE.**Referenced Sources: Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2022). The serotonin theory of depression: A systematic umbrella review of the evidence. Molecular Psychiatry, 28(8), 1–14. https://doi.org/10.1038/s41380-022-01661-0Website: https://www.riseaswe.com/podcastEmail: amanda@riseaswe.comInstagram: https://www.instagram.com/amandaontherise/TikTok: https://www.tiktok.com/@amandaontherise

L'anxiété est un trouble mental touchant des millions de personnes dans le monde, mais son diagnostic repose encore largement sur des évaluations subjectives, basées sur les symptômes rapportés par les patients. Une équipe dirigée par le professeur de psychiatrie Alexander Niculescu a récemment franchi une étape majeure en développant un test sanguin capable d'évaluer objectivement le niveau d'anxiété d'un individu. Leurs travaux, publiés dans la revue *Molecular Psychiatry*, ouvrent la voie à une approche plus précise et personnalisée du traitement des troubles anxieux.Une approche biomoléculaire innovanteL'équipe de Niculescu s'est appuyée sur des recherches antérieures où ils avaient identifié des biomarqueurs sanguins pour la douleur, la dépression, le trouble bipolaire et le syndrome de stress post-traumatique. Pour cette nouvelle étude, les chercheurs ont utilisé des techniques avancées d'analyse génétique et d'intelligence artificielle pour identifier des biomarqueurs spécifiques associés à l'anxiété.Leur méthodologie repose sur un principe simple mais efficace : comparer les profils sanguins de patients souffrant d'anxiété à ceux de groupes témoins, en cherchant des différences d'expression de certains gènes. Ces marqueurs biologiques, liés aux circuits du stress et de la régulation émotionnelle, permettent de quantifier le niveau d'anxiété de manière objective.Des résultats prometteurs pour un diagnostic de précisionLes tests menés par l'équipe ont montré que ces biomarqueurs sanguins pouvaient non seulement mesurer l'intensité de l'anxiété, mais aussi prédire le risque de rechute ou d'aggravation chez les patients. De plus, ces marqueurs pourraient aider à personnaliser les traitements en identifiant les médicaments les plus adaptés en fonction du profil biologique de chaque individu.Vers une médecine psychiatrique plus objectiveCette avancée représente une révolution potentielle dans le diagnostic et le traitement des troubles anxieux. Un test sanguin pourrait permettre un repérage précoce, une meilleure évaluation des traitements et un suivi plus précis des patients. Toutefois, ces résultats doivent encore être validés par des essais cliniques à grande échelle avant d'être intégrés à la pratique médicale.En attendant, ces travaux marquent une avancée significative vers une psychiatrie plus objective et fondée sur des preuves biologiques, réduisant ainsi la part de subjectivité dans le diagnostic des troubles mentaux. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

As ruminações são pensamentos repetitivos negativos, às vezes inócuos, mas que podem estar relacionados a quadros de depressão e ansiedade. Elas decorrem muitas vezes de decepções ou frustrações que levam algumas pessoas a “remoer” situações sem conseguir superá-las, explica o psiquiatra Jean-Luc Martinot, pesquisador do Inserm (Instituto de Pesquisas Médicas da França). Taíssa Stivanin, da RFI em Paris Segundo o especialista francês, as ruminações são um fenômeno subjetivo, vivenciado pela maior parte das pessoas e “difícil” de ser estudado. Mas algumas características desses pensamentos repetitivos já puderam ser estabelecidas pelos cientistas, como mostra um recente estudo dirigido pelo psiquiatra francês e publicado na revista científica Molecular Psychiatry.Um dos objetivos dessa pesquisa era identificar sinais no cérebro de jovens adultos entre 18 e 22 anos de que essas ruminações poderiam desencadear doenças mentais no futuro. A equipe focou nessa faixa etária porque esses pensamentos "invasivos", explica o psiquiatra francês, surgem principalmente na passagem da adolescência para a fase adulta. “As ruminações são algo frequente e não são uma característica da infância ou do início da adolescência”, explica o psiquiatra francês. “É um fenômeno da vida mental que pode até existir antes, mas que se torna mais frequente quando os jovens viram adultos”, completa.Descrição do estudoDurante a pesquisa, os cientistas franceses analisaram os dados de centenas de jovens europeus que responderam, durante vários anos, a questionários online sobre esses pensamentos frequentes, que causam desconforto e ansiedade.Periodicamente, eles eram submetidos a exames de ressonância magnética para detectar se havia mudanças na atividade cerebral quando os pensamentos repetitivos surgiam espontaneamente.Os pesquisadores então identificaram, no grupo de 600 jovens acompanhados pela equipe, aqueles que descreveram ruminações depressivas. Eles foram submetidos a uma ressonância magnética “livre”, que mede a atividade cerebral sem instruções dadas pela equipe médica.“O estado mental dos pacientes que tinham tendência às ruminações foi naturalmente captado pelo aparelho”, explica. O registro foi possível graças a um algoritmo que permite diferenciar a maneira como a atividade mental evolui no cérebro e conecta ao mesmo tempo diferentes regiões. “Por exemplo, durante as ruminações 'preocupantes', percebemos que havia regiões frontais que variavam ao mesmo tempo que algumas áreas dos gânglios da base, ou seja, áreas envolvidas na gestão das emoções”.Ruminações são divididas em três tiposA equipe do psiquiatra francês dividiu os pensamentos repetitivos em três tipos. As chamadas ruminações reflexivas têm uma conotação positiva e consistem na busca da solução para um problema. Os outros dois tipos estão relacionados às emoções negativas e às preocupações cotidianas, ou podem estar associadas à depressão. “A ruminação depressiva, pode, se persistir, pode ser primeiro sinal de um problema psiquiátrico mais grave”, diz o psiquiatra. Os pacientes que apresentavam ruminações negativas aos 18 anos tinham uma tendência maior ao desenvolvimento de sintomas de ansiedade e depressão, às vezes graves, quatro anos depois.A gravidade dos sintomas estava relacionada às modificações nas configurações cerebrais medidas durante as ressonâncias magnéticas. “Certos tipos de ruminações, como as relacionadas às preocupações, ou depressivas, anunciam o surgimento de sintomas internos, ou seja, de ansiedade ou depressão, ou externos, como agressividade, uso de drogas ou dependência química”.Isso pode ajudar a prevenir doenças mentais em jovens adultos com fatores de risco – e este é um dos interesses concreto do estudo. Segundo o psiquiatra, a gestão das emoções, certas características de personalidade, o padrão de sono, a existência de traumatismos e a puberdade precoce influenciam no surgimento de doenças psiquiátricas e podem prevenir seu aparecimento.

"What the herd hates most is the one who thinks differently; it is not so much the opinion itself, but the audacity of wanting to think for themselves, something that they do not know how to do." — Arthur Schopenhauer (1788–1860) Throughout the world, mental capacity is declining, especially among young people, while depression rates are rising dramatically. Meanwhile, one in forty men and women suffers from Alzheimer's, and the age of onset is falling rapidly. But the causes are not being eliminated, quite the opposite. Can this just be coincidence? The Indoctrinated Brain - How to Defend Your Mental Freedom with Michael Nehls, MD, PhD Nehls, a medical doctor and internationally renowned molecular geneticist, lays out a shattering chain of circumstantial evidence in his book "" indicating that behind these numerous negative influences lies a targeted, masterfully executed attack on our individuality. He points out how the raging wars against viruses, about climate change, or over national borders are—more likely intended than not—fundamentally providing the platform for such an offensive against the human brain that is steadily changing our being and is aimed at depriving us of our ability to think for ourselves. As a basic researcher, he deciphered the genetic causes of dozens of hereditary diseases at German and international research institutions. Two of his discoveries were published in collaboration with two Nobel Prize winners. Another discovery of a key gene in immunity development was honored by the renowned American Association of Immunologists as a "Pillar of Immunology." For his pioneering findings on Alzheimer's disease development, prevention, and therapy, he was awarded the Hanse Prize for Molecular Psychiatry by the Rostock University Hospital. Dr. Nehls was vice president of genome research at a US company for three years and chief scientific officer and CEO of a Munich-based biotechnology company for eight years. A scientific author talented in making complex topics understandable to a wide audience, he has written several bestsellers that have been translated into many languages. As a private lecturer, he delivers lectures at congresses and universities, attracting wide audiences. Michael Nehls MD PhD, The Indoctrinated Brain, global attack on humanity, defend mental freedom, attack on individuality, wars on climate change, wars on viruses, global influence on the brain, mental health and individuality, thinking for yourself

O novo primeiro-ministro francês, Michel Barnier, apresentou nesta semana seu programa de governo. Entre vários anúncios, ele previu que a grande questão da França em 2025 será a saúde mental da população, afetada por sucessivas crises, entre elas, a pandemia de Covid-19. Todos os anos, o governo francês anuncia uma questão considerada urgente no país. A escolha é feita desde 1977 por meio de um concurso público do qual do qual participam organizações e associações.Para 2025, a saúde mental foi contemplada, o que permitirá, além do debate e da apresentação de novas medidas, a difusão de uma campanha de sensibilização pelas mídias públicas francesas.O anúncio de Barnier chega em um momento em que a questão da saúde mental é considerada uma emergência. Cerca de 13 milhões de franceses sofrem de doenças psicológicas ou psiquiátricas, o que representa uma em cada cinco pessoas no país.Segundo Barnier, o foco será a prevenção e envolverá diversas instâncias: “o Estado, as administrações regionais, empresas e associações”. Para o primeiro-ministro, a saúde mental “é responsabilidade de todos”.Pandemia afetou a saúde mental dos franceses“Crises sucessivas e principalmente a da Covid-19” tiveram um impacto expressivo na saúde mental da população francesa, lembrou o primeiro-ministro. De fato, vários estudos e pesquisas relacionam a degradação do bem-estar na França como um efeito da crise sanitária.A Agência Nacional de Saúde Pública, registrou um aumento de casos de depressão durante a pandemia. A faixa etária mais penalizada foi a dos 18 aos 24 anos, que sofreu um salto de mais de 20% em episódios depressivos.Já uma pesquisa realizada na rede pública de hospitais de Paris e publicada no último 20 de setembro na revista científica Molecular Psychiatry associa casos graves de Covid-19, principalmente os que necessitaram de hospitalização, ao desenvolvimento de psiquiátricas. Cerca de 35 mil pacientes foram avaliados, entre os quais cerca de 10% foram vítimas de depressão e ansiedade após as internações.No primeiro semestre deste ano, o instituto Ipsos também quantificou a importância da saúde mental na França. De acordo com a sondagem, 55% dos franceses pensa frequentemente na questão. Um quarto da população afirma ter se sentido deprimido durante várias semanas ao menos uma vez no ano, em 2023.A pesquisa ainda mostra que a faixa etária dos 18 anos 24 anos é a que menos reage ao perceber um distúrbio mental, por não saber como agir ou a quem recorrer. Além disso, o balanço do Ispos mostra que as mulheres têm a tendência de considerar que não têm tempo para cuidar da saúde mental. Já os homens, em geral, são resistentes em buscar uma ajuda profissional por considerá-la inútil.Gastos anuais de € 23 bilhões em saúde mentalA França gasta atualmente mais de € 23 bilhões anuais no atendimento e tratamento de doenças e distúrbios psicológicos e psiquiátricos, o que representa 14% das despesas totais na saúde. Por isso, para o primeiro-ministro, a estratégia da prevenção pode resultar em economias no futuro na diminuição da quantidade de consultas médicas, hospitalizações e reincidência.As patologias psicológicas e psiquiátricas são o segundo motivo de atestados médicos atualmente nas empresas francesas. Já os afastamentos do trabalho de longa duração, superiores a um mês, estão em primeiro lugar, principalmente devido à depressão e ao burn out.A urgência e a gravidade da questão da saúde mental na França leva profissionais do setor a expressar ceticismo sobre as promessas de Barnier. Para eles, o governo deve se concentrar em quatro pontos: o fim da estigmatização das doenças mentais, a prevenção, formação de outros setores da saúde para aliviar a pressão sobre psicólogos e psiquiatras e um maior recrutamento de profissionais especializados em saúde mental.O Sindicato dos Psiquiatras de Hospitais da França afirma que 48% das vagas de profissionais especializados em saúde mental não estão ocupadas e que o setor está submerso. Ao mesmo tempo em que a quantidade de pacientes quase triplicou em pouco mais de 20 anos nos ambulatórios psiquiátricos da França, 88 mil leitos foram fechados. Nos hospitais públicos, médicos afirmam que se veem obrigados a triar pacientes para dar prioridade aos casos mais graves.

La consommation de cigarettes a un impact négatif sur la taille du cerveau, notamment en provoquant une réduction du volume de certaines régions cérébrales. Une étude publiée dans la revue *Molecular Psychiatry* a révélé que le tabagisme chronique est associé à une diminution du volume cortical, particulièrement dans les régions frontales et temporales du cerveau, zones impliquées dans des fonctions cognitives telles que la prise de décision et la mémoire. Les chercheurs ont observé que les fumeurs présentaient un amincissement cortical plus prononcé comparé aux non-fumeurs. Ce phénomène est attribué aux effets neurotoxiques de la nicotine et d'autres substances chimiques présentes dans la fumée de cigarette, qui endommagent les cellules neuronales et entravent la neuroplasticité, c'est-à-dire la capacité du cerveau à se réorganiser et à créer de nouvelles connexions. Une diminution de la taille du cerveau est également liée à un risque accru de troubles cognitifs et de déclin mental. L'étude suggère que même après l'arrêt du tabagisme, la récupération du volume cortical est limitée, bien que certains effets puissent s'améliorer avec le temps. Cela démontre l'importance de cesser de fumer le plus tôt possible pour limiter les dégâts cérébraux. Les résultats de cette recherche soulignent le lien direct entre le tabagisme et la réduction de la taille du cerveau, et mettent en avant la nécessité de stratégies de prévention et de traitement pour minimiser l'impact négatif du tabac sur la santé cognitive à long terme. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Episode 49 – Abnormal Repetitive Behaviours in Dogs – What You Need To Know!   Abnormal Repetitive Behaviours in dogs are challenging to diagnose and treat. Their genetic and heritable nature, the large number of physical medical differential diagnoses and their ritualistic and invariant nature can make them difficult to live with and their treatment really requires the help and support of an expert!   In this episode you will learn: 1.      The definition of Abnormal Repetitive Behaviours 2.      The big 5 groups of ARBs 3.      What we need to think about when it comes to physical medical rule outs 4.      What breeds are predisposed 5.      How to treat these patients   Here are some of the resources Dr Katrin mentions in this episode: 1.      Moon-Fanelli, A. A., Dodman, N. H., & Cottam, N. (2007). Blanket and flank sucking in Doberman Pinschers. Journal of the American Veterinary Medical Association, 231(6), 907–912. https://doi.org/10.2460/javma.231.6.907   2.      Dodman, N. H., Karlsson, E. K., Moon-Fanelli, A., Galdzicka, M., Perloski, M., Shuster, L., Lindblad-Toh, K., & Ginns, E. I. (2010). A canine chromosome 7 locus confers compulsive disorder susceptibility. Molecular Psychiatry, 15(1), 8–10. https://doi.org/10.1038/mp.2009.111 We really hope you enjoy this episode; it is packed with so much information!   If you liked this episode of the show, The Pet Behaviour Chat, please LEAVE A 5-STAR REVIEW, like, share, and subscribe!   Facebook Group: Join The Pet Behaviour Community on Facebook   You can CONNECT with me: Website: Visit my website Trinity Veterinary Behaviour Instagram: Follow Trinity Veterinary Behaviour on Instagram Trinity Veterinary Behaviour Facebook: Join us on Trinity Veterinary Behaviour's Facebook page Trinity Veterinary Behaviour YouTube: Subscribe to Trinity Veterinary Behaviour on YouTube LinkedIn Profile: Connect with me on LinkedIn   Thank you for tuning in!

FREEDOM - LIBERTY - HAPPINESS SUPPORT DOC MALIK To make sure you don't miss any episodes please subscribe to either: The paid Spotify subscription here: ⁠https://podcasters.spotify.com/pod/show/docmalik/subscribe The paid Substack subscription here: ⁠https://docmalik.substack.com/subscribe ABOUT THIS CONVERSATION: Michael graduated from medicine in 1986 in Germany but never practised clinical medicine. Instead, he went into research and now has published several books mainly in German. Michael's article titled "Unified Theory of Alzheimer's Disease (UTAD): implications for prevention and curative therapy" was internationally published in the Journal of Molecular Psychiatry. For his breakthrough discovery regarding the development, prevention and therapy of Alzheimer's disease, he received the 2015 Hanse Award for Psychiatry from the University of Rostock, Germany. “The Indoctrinated Brain - How to Successfully Fend Off the Global Attack on Your Mental Freedom” is his latest and arguably greatest work. In it, Michael talks about the effects of the mRNA COVID-19 vaccines on human cognition and autonomy. Nehls suggests that these vaccines, among other modern pressures, and propaganda methods are part of a global assault manipulating the human mind, aiming to facilitate increased governmental control over individuals, A global war on the human mind. You can read more about this episode on my substack. Subscribe if you haven't already and keep abreast of the latest with Doc Malik and my writings. I hope you enjoy the episode. Much love Ahmad x Links X Michael Nehls Website Michael Nehls IMPORTANT INFORMATION AFFILIATE CODES Hunter & Gather Foods ⁠Hunter & Gather Foods Use DOC15 to get 15% OFF your first purchase with Hunter & Gather Foods, and DOC10 for 10% off all further purchases. IMPORTANT NOTICE Following my cancellation for standing up for medical ethics and freedom, my surgical career has been ruined. I am now totally dependent on the support of my listeners, YOU. If you value my podcasts, please support the show so that I can continue to speak up by choosing one or both of the following options - ⁠Buy me a coffee⁠ If you want to make a one-off donation. Join my Substack To access additional content, you can upgrade to paid from just £5.50 a month Doc Malik Merch Store⁠ Check out my amazing freedom merch To sponsor the Doc Malik Podcast contact us at ⁠hello@docmalik.com⁠

Un recente studio dell'Università di Cincinnati ha esplorato l'impatto dello stress materno durante la gravidanza sul neurosviluppo dei bambini. Questa ricerca, pubblicata su Molecular Psychiatry, analizza come eventi di vita stressanti prenatali siano associati a esiti avversi nei neonati, focalizzandosi sull'epigenomica e sulle “modificazioni” del DNA, in particolare la metilazione.Approfondimenti: www.FITGENETICA.comwww.fitgenetica.com

Nei traumi relazionali, l'esperienza traumatica è legata alle relazioni interpersonali. Questo potrebbe includere abusi emotivi, fisici o sessuali da parte di persone significative come genitori, partner o altre figure di fiducia. In questo contesto, il trauma può influenzare profondamente il modo in cui la persona percepisce se stessa e gli altri, causando disturbi dell'attaccamento e problemi nelle relazioni future. D'altra parte, i traumi non relazionali non sono necessariamente legati alle relazioni interpersonali, ma possono derivare da eventi come incidenti gravi, disastri naturali, violenza casuale o altre situazioni in cui la persona non è direttamente coinvolta con altre persone come fonte di trauma. In questi casi, il trauma può ancora avere un impatto significativo sulla percezione di sé e sul benessere emotivo, ma l'aspetto relazionale può essere meno predominante rispetto ai traumi legati alle relazioni interpersonali. Questo è quanto evidenzia una ricerca pubblicata su Molecular Psychiatry che commentiamo a Obiettivo Salute con il prof. Andrea Scalabrini, dell’Università degli Studi di Bergamo che insieme alla Prof.ssa Clara Mucci dell’Università degli studi di Bergamo ha coordinato la ricerca che ha visto anche il contributo del Dott. Marco Cavicchioli e Prof. Francesco Benedetti dell’Università Vita Salute San Raffaele e il neuroscienziato di fama internazionale Prof. Georg Northoff.

In this episode of our "Mental Health Is Physical Health" series, Dr. Will Cole delves into the intricate landscape of mental well-being with his functional medicine telehealth team. The team unravels the history of mental health, tackles controversies surrounding antidepressants, and discusses the significance of informed consent in medication decisions. This episode will explore how inflammation impacts mood and brain function, as well as the functional medicine approach to mental wellbeing. From supplements, therapies, and mindfulness practices, you will learn about tools to support reclaiming your mental health. Plus, listen until the end for an intimate conversation from a previous patient. For all links mentioned in episode: www.drwillcole.com/podcastStudies Referenced: Review: benefits of antidepressants over placebo limited except in very severe depression. BMJ Mental Health: https://mentalhealth.bmj.com/content/13/2/49Placebo Effect in the Treatment of Depression and Anxiety. Frontiers in Psychiatry: https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00407/fullThe serotonin theory of depression: a systematic umbrella review of the evidence. Molecular Psychiatry :https://www.nature.com/articles/s41380-022-01661-0Cold plunge article for benefits , code drwillcole for discount: https://drwillcole.com/functional-medicine/is-cold-therapy-worth-it-a-functional-medicine-guide-to-cold-plunges-cryotherapy-moreSunlighten article, Save up to $600 on your purchase by mentioning Dr. Will Cole. Click the link in bio : https://drwillcole.com/detoxing-toxins/the-top-8-infrared-sauna-health-benefits-how-to-find-the-best-sauna-for-youPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Visit www.hummkombucha.com and use code drwillcole for 15% off your total order. Find Humm on Amazon for free shipping with Amazon Prime and delivery to anywhere in the US!Try AG1 and get a FREE1-year supply of Vitamin D3+K2 AND for a limited time you'll get 10 free AG1 Travel Packs with your first purchase at drinkAG1.com/willcole.Right now, when you go to justthrivehealth.com and use promo code: DRWILL you can get 20% off a 90 day bottle of JustThrive Probiotic and Just Calm...That's like getting a month for FREE!LMNT came up with a fantastic offer for us. Just go to DrinkLMNT.com/WILLCOLE to get a free sample pack with any purchase!Elevate your hair wellness routine this year with Vegamour. For a limited time get twenty percent off your first subscription order by going to VEGAMOUR.com/willcole and use code willcole at checkout. Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

 GDP Script/ Top Stories for Feb 14th   Publish Date:  Feb 13th   From the Drake Realty Studio Welcome to the Gwinnett Daily Post Podcast. Today is Wednesday, February 14th and Happy 51st Birthday to Matchbox 20's Rob Thomas. ***02.14.24 – BIRTHDAY – ROB THOMAS*** I'm Bruce Jenkins and here are your top stories presented by Tom Wages Funeral Homes. Double Murder Case Resolved: Kennesaw Man Found Guilty in Lawrenceville Suspected Shoplifter's Aim: Selling Stolen Tools for Basic Necessities Study Reveals: Bullied Teens at Higher Risk of Experiencing Psychotic Episodes Plus, my conversation with Leah McGrath from Ingles Markets on microwave meals. All of this and more is coming up on the Gwinnett Daily Post podcast, and if you are looking for community news, we encourage you to listen daily and subscribe! Break 1: TOM WAGES   STORY 1: Kennesaw Man Convicted In Lawrenceville Double Murder Case Steven Tran, a 23-year-old man from Cobb County, has been handed dual life sentences plus five years without the possibility of parole. The sentencing comes after Tran was found guilty of a double murder and threatening another person during a drug transaction in 2020. The charges against him included malice murder, felony murder, aggravated assault, and possession of a firearm during the commission of a felony. Tran had planned to purchase marijuana from An Ha and Julian Talbo but instead robbed them and ended their lives at a residence in Lawrenceville. He also menaced a woman with a firearm. Following the collection of substantial evidence, Tran confessed, leading to his conviction. Gwinnett County District Attorney Patsy Austin-Gatson expressed her contentment in bringing justice to the victims' families. STORY 2: Shoplifting Suspect Wanted To Sell Stolen Tools To Make Money For Food, Lodging Kevin Elam, a 36-year-old Indianapolis native, was caught attempting to steal DeWalt power tools from an Ace Hardware store near Loganville. His intention was to sell the stolen items to fund his food and shelter needs. Despite making a getaway in a Nissan Rouge, diligent store employees were able to provide the police with a detailed vehicle description and tag number. Surveillance camera analysts located the vehicle and relayed the information to the officers, resulting in Elam's arrest just 8.2 miles from the store. The stolen tools, valued at $1,271, were recovered. Elam admitted to the theft, attributing it to financial strain, and is currently being held in Gwinnett County Jail on a felony theft by shoplifting charge, with a bond set at $4,600. STORY 3: Bullied teens more at risk of suffering psychotic episodes Recent research has unveiled that teenagers who are victims of bullying are more prone to experiencing early psychotic episodes. This is attributed to reduced glutamate levels, a neurotransmitter that controls emotions in the brain's anterior cingulate cortex (ACC). The study, published in Molecular Psychiatry, suggests that focusing on glutamate could decrease the likelihood of psychotic disorders in bullied teens. Psychosis, defined by a disconnection from reality and hallucinations, is linked with altered glutamate levels. Researchers from the University of Tokyo used magnetic resonance spectroscopy to evaluate glutamate levels in adolescents, establishing a correlation between bullying experiences and subclinical psychotic symptoms. The lead author, Dr. Naohiro Okada, advocates for anti-bullying initiatives and mental health support as preventative strategies. Non-drug interventions like cognitive behavioral therapy could rectify neurotransmitter imbalances in bullied adolescents. We have opportunities for sponsors to get great engagement on these shows. Call 770.874.3200 for more info. We'll be right back. Break 2: HENRY COUNTY SHERRIF   STORY 4: Ex-beauty queen inspiring other women experiencing hair loss Dr. Bhasha Mukherjee, a former Miss England winner, has come forward about her own struggles with female-pattern baldness during her reign. Mukherjee, who resorted to using eye shadow and hair extensions to cover up thinning hair, is now dedicated to breaking down stigmas associated with the topic. She stresses the unrealistic beauty expectations placed on women and advocates for open conversations about hair loss, challenging the prevalent notion that femininity is tied to voluminous hair. Mukherjee also shines a light on how modern lifestyle factors can affect hair health and welcomes the idea of a hair loss brand sponsoring the Miss England pageant, marking a progressive step towards addressing the issue. STORY 5: These kids are first in world to get special Marvel superhero bionic arms Kaden Taylor and Safiyyah Uddin, two British children born with partial limbs, have become the world's first recipients of Spider-Man-themed bionic prosthetics. The innovative prosthetics, a result of a collaboration between Marvel and Disney and manufactured by Open Bionics, are 3D-printed and equipped with myoelectric sensors that respond to muscle contractions. Safiyyah is delighted with her pink Hero Arm, which mirrors Spider-Woman, and is now able to perform tasks using both hands. Kaden, who was initially reluctant about prosthetics, has enthusiastically adopted his Spider-Man Hero Arm, significantly boosting his confidence and enabling him to participate in activities such as bike riding. Open Bionics has plans to develop more superhero-themed prosthetics and is currently searching for a candidate with a limb difference to represent "Miles Morales" in their upcoming project.   We'll be back in a moment.   Break 3: INGLES 9 STORY 6: LEAH MCGRATH And now here is my conversation with Leah McGrath from Ingles Markets on microwave meals.   STORY 7: LEAH MCGRATH ***LEAH MCGRATH INERVIEW***   Break 4: Signoff – Thanks again for hanging out with us on today's Gwinnett Daily Post podcast. If you enjoy these shows, we encourage you to check out our other offerings, like the Cherokee Tribune Ledger Podcast, the Marietta Daily Journal, the Community Podcast for Rockdale Newton and Morgan Counties, or the Paulding County News Podcast. Read more about all our stories and get other great content at Gwinnettdailypost.com. Did you know over 50% of Americans listen to podcasts weekly? Giving you important news about our community and telling great stories are what we do. Make sure you join us for our next episode and be sure to share this podcast on social media with your friends and family. Add us to your Alexa Flash Briefing or your Google Home Briefing and be sure to like, follow, and subscribe wherever you get your podcasts. Produced by the BG Podcast Network   Show Sponsors: ingles-markets.com wagesfuneralhome.com gcpsk12.org/jobs gov   #NewsPodcast #CurrentEvents #TopHeadlines #BreakingNews #PodcastDiscussion #PodcastNews #InDepthAnalysis #NewsAnalysis #PodcastTrending #WorldNews #LocalNews #GlobalNews #PodcastInsights #NewsBrief #PodcastUpdate #NewsRoundup #WeeklyNews #DailyNews #PodcastInterviews #HotTopics #PodcastOpinions #InvestigativeJournalism #BehindTheHeadlines #PodcastMedia #NewsStories #PodcastReports #JournalismMatters #PodcastPerspectives #NewsCommentary #PodcastListeners #NewsPodcastCommunity #NewsSource #PodcastCuration #WorldAffairs #PodcastUpdates #AudioNews #PodcastJournalism #EmergingStories #NewsFlash #PodcastConversationsSee omnystudio.com/listener for privacy information.

As anyone who's experienced depression can tell you, it's brutal. And, with almost 1 in 4 American women taking antidepressants, it's clear many of us are suffering. What's going on? What's to be done? In this latest episode of our “Love & Life:  Let's Talk About It” series, Miriam Conner and I explore depression in America—especially as it relates to women. Specifically, we consider: How depression is conceptualized.  The evidence that debunks the “chemical imbalance” explanation. Why antidepressants don't work. Lifestyle factors that contribute to depression. Spoiler alert:  pretty much everything in the standard American lifestyle contributes to it! Research based strategies to liberate us from the clutches of depression! Join us to learn how to break free from the grip of depression! N.B. Please DO NOT quit taking antidepressants without the consultation and guidance of a professional trained in how to taper off SSRIs safely. Antidepressant Discontinuation Syndrome can result when abruptly terminating SSRIs. This conversation does not prescribe medical or psychological advice and should not be taken as such.   Sponsor The Wellness Company Website: ⁠https://www.twc.health/lovelife⁠ Code: LOVELIFE for 15% off your order! Miriam Conner Podcast: ⁠aParently Speaking⁠ Facebook: https://www.facebook.com/aParentlySpeakingPodcast/ Dr. Karin  Website: http://loveandlifemedia.com/ Instagram: @dr.karin  Sources: Our conversation was based on Dr. Joseph Mercola's article, “Gross Misconduct—The Final Nail in the Coffin for Antidepressants.”  Mercola, J. (2024, January 29). Gross misconduct—The final nail in the coffin for antidepressants. Substack.  Moncrieff, J., Cooper, R.E., Stockmann, T. et al. (2023). The serotonin theory of depression: A systematic umbrella review of the evidence. Molecular Psychiatry 28, 3243–3256. https://doi.org/10.1038/s41380-022-01661-0 https://www.madinamerica.com/2023/09/the-stard-scandal-scientific-misconduct-on-a-grand-scale/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/love-and-life-media/message

Michael Nehls, MD, PhD, is a medical physician with a doctorate in molecular genetics, specializing in immunology. Over the years Dr Nehls has identified the genetic causes of dozens of hereditary diseases, including in collaboration with two Nobel Prize winners. He is one of leading pioneers in Alzheimer Disease and dementia research along with therapeutic means to prevent and treat these neurological illnesses. Michael has received many awards, including the Hanse Prize for Molecular Psychiatry. Earlier he was a vice president of an American genomic research company and the CEO and chief science officer of a German biotechnology firm. He has written several bestsellers in Germany, and his books have been translated in many languages. His most recent book has been translated into English -- The Indoctrinated Brain: How to Successfully Fend Off the Global Attack on Your Mental Freedom. His website in Michael-Nehls.com. Michael also hosts a substack page with his regular articles at MichaelNehls.substack.com. 

“Michael Nehls has written a provocative book arguing that the COVID-19 generation in particular will ultimately be deficient in memory and cognition, due to the combination of brainwashing and toxic exposures,” writes Stephanie Seneff, senior research scientist at MIT, about Dr. Nehl's book “The Indoctrinated Brain.” Dr. Michael Nehls is a physician and molecular geneticist specializing in immunology. As a basic researcher, he deciphered the genetic causes of dozens of hereditary diseases at German and international research institutions. Two of his discoveries were published in collaboration with two Nobel Prize winners. For his pioneering findings on Alzheimer's disease development, prevention, and therapy, he was awarded the Hanse Prize for Molecular Psychiatry by the Rostock University Hospital. Dr. Nehls is the author of “The Indoctrinated Brain: How to Successfully Fend Off the Global Attack on Your Mental Freedom”. Follow him at https://x.com/NehlsMD and find more at https://michael-nehls.com 「 SPONSORED BY 」 Find out more about the companies that make this show possible and get special discounts on amazing products at https://drdrew.com/sponsors • COZY EARTH - Susan and Drew love Cozy Earth's sheets & clothing made with super-soft viscose from bamboo! Use code DREW for a huge discount at https://drdrew.com/cozy • PROVIA - Dreading premature hair thinning or hair loss? Provia uses a safe, natural ingredient (Procapil) to effectively target the three main causes of premature hair thinning and hair loss. Susan loves it! Get an extra discount at https://proviahair.com/drew • PALEOVALLEY - "Paleovalley has a wide variety of extraordinary products that are both healthful and delicious,” says Dr. Drew. "I am a huge fan of this brand and know you'll love it too!” Get 15% off your first order at https://drdrew.com/paleovalley • GENUCEL - Using a proprietary base formulated by a pharmacist, Genucel has created skincare that can dramatically improve the appearance of facial redness and under-eye puffiness. Get an extra discount with promo code DREW at https://genucel.com/drew • THE WELLNESS COMPANY - Counteract harmful spike proteins with TWC's Signature Series Spike Support Formula containing nattokinase and selenium. Learn more about TWC's supplements at https://twc.health/drew 「 MEDICAL NOTE 」 Portions of this program may examine countervailing views on important medical issues. Always consult your personal physician before making any decisions about your health. 「 ABOUT THE SHOW 」 Ask Dr. Drew is produced by Kaleb Nation (https://kalebnation.com) and Susan Pinsky (https://twitter.com/firstladyoflove). This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. 「 ABOUT DR. DREW 」 Dr. Drew is a board-certified physician with over 35 years of national radio, NYT bestselling books, and countless TV shows bearing his name. He's known for Celebrity Rehab (VH1), Teen Mom OG (MTV), The Masked Singer (FOX), multiple hit podcasts, and the iconic Loveline radio show. Dr. Drew Pinsky received his undergraduate degree from Amherst College and his M.D. from the University of Southern California, School of Medicine. Read more at https://drdrew.com/about Learn more about your ad choices. Visit megaphone.fm/adchoices

Dziś poruszam temat, który niepokoi wielu rodziców i opiekunów: związek między autyzmem a nadmiernym korzystaniem z ekranów i urządzeń elektronicznych. Wyjaśniam nie tylko, jak nadmierne korzystanie z technologii wpływa na dzieci z autyzmem, oraz jakie są udokumentowane badaniami konsekwencje tego zjawiska. Podaję kilka praktycznych wskazówek.Badania będące podstawą każdego z twierdzeń, które padły w podcaście:[1] Melke, J., Goubran-Botros, H., Chaste, P., et al. (2007). Abnormal melatonin synthesis in autism spectrum disorders. Molecular Psychiatry, 13(1), 90–98.Higuchi, S., Motohashi, Y., Liu, Y., et al. (2003). Effects of VDT tasks with a bright display at night on melatonin, core temperature, heart rate, and sleepiness. Journal of Applied Physiology, 94(5), 1773–1776.[2] Goodwin, M. S., Groden, J., Velicer, W. F., et al. (2006). Cardiovascular arousal in individuals with autism. Focus on Autism and Other Developmental Disabilities, 21(2), 100–123.Corbett, B. A., & Simon, D. (2013). Stress and cortisol in autism spectrum disorders. OA Autism, 1(1), 1–6. Wallenius, M. (2010). Salivary cortisol in relation to the use of information and communication technology (ICT) in school-aged children. Psychology, 1(2), 88–95.Mark, A. E., & Janssen, I. (2008). Relationship between screen time and metabolic syndrome in adolescents. Journal of Public Health, 30(2), 153–160.Goldfield, G. S., Kenny, G. P., Hadjiyannakis, S., et al. (2011). Video game playing is independently associated with blood pressure and lipids in overweight and obese adolescents. PLoS ONE, 6(11), e26643.[3] Theoharides, T. C., Asadi, S., & Patel, A. B. (2013). Focal brain inflammation and autism. Journal of Neuroinflammation, 10(1), 46.Ranjbaran, Z., Keefer, L., Farhadi, A., et al. (2007). The relevance of sleep abnormalities to chronic inflammatory conditions. Inflammation Research, 56(2), 51–57.Cajochen, C., Frey, S., Anders, D., et al. (2011). Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance. Journal of Applied Physiology, 110(5), 1432–1438.[4] Just, M. A., Keller, T. A., & Kana, R. K. (2013). A theory of autism based on frontal-posterior underconnectivity. In Development and Brain Systems in Autism (pp. 35–63).Rowan, C. (2010). Unplug—Don't drug: A critical look at the influence of technology on child behavior with an alternative way of responding other than evaluation and drugging. Ethical Human Psychology and Psychiatry, 12(1), 60–68.Dunckley, V. L. (2014, February 27). Gray matters: Too much screen time damages the brain. Psychology Today.Weng, C.-B., Qian, R.-B., Fu, X.-M., et al. (2013). Gray matter and white matter abnormalities in online game addiction. European Journal of Radiology, 82(8), 1308–1312.[5] Adolphs, R., Sears, L., & Piven, J. (2001). Abnormal processing of social information from faces in autism. Journal of Cognitive Neuroscience, 13(2), 232–240.Uhls, Y. T., Michikyan, M., Morris, J., et al. (2014). Five days at outdoor education camp without screens improves preteen skills with nonverbal cues. Computers in Human Behavior, 39, 387–392.Pea, R., Nass, C., Meheula, L., et al. (2012). Media use, face-to-face communication, media multitasking, and social well-being among 8- to 12-year-old girls. Developmental Psychology, 48(2), 327–336.Heffler, K. F., & Oestreicher, L. M. (2016). Causation model of autism: Audiovisual brain specialization in infancy competes with social brain networks. Medical Hypotheses, 91, 114–122.Chonchaiya, W., & Pruksananonda, C. (2008). Television viewing associates with delayed language development. Acta Pædiatrica, 97(7), 977–982.[6] White, S. W., Oswald, D., Ollendick, T., et al. (2009). Anxiety in children and adolescents with autism spectrum disorders. Clinical Psychology Review, 29(3), 216–229.Ha, J. H., Yoo, H. J., Cho, I. H., et al. (2007). Psychopathology and internet addiction in adolescents. Psychopathology, 40(6), 424–430.Pea, R., Nass, C., Meheula, L., Rance, M., Kumar, A., Bamford, H., Nass, M., Simha, A., Stillerman, B., Yang, S., & Zhou, M. (2012). Media use, face-to-face communication, media multitasking, and social well-being among 8- to 12-year-old girls. Developmental psychology, 48(2), 327–336. Chugani, D. C., Muzik, O., Behen, M., et al. (1999). Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Annals of Neurology, 45(3), 287–295.Adolphs, R., Sears, L., & Piven, J. (2001). Abnormal processing of social information from faces in autism. Journal of cognitive neuroscience, 13(2), 232–240. Kohyama J. (2011). Neurochemical and neuropharmacological aspects of circadian disruptions: an introduction to asynchronization. Current neuropharmacology, 9(2), 330–341. Mathiak, K., & Weber, R. (2006). Toward brain correlates of natural behavior: fMRI during violent video games. Human brain mapping, 27(12), 948–956. [7] Dawson, G., & Watling, R. (2000). Interventions to facilitate auditory, visual, and motor integration in autism: a review of the evidence. Journal of autism and developmental disorders, 30(5), 415–421. Rowan C. (20100, The Impact of Technology on Child Sensory and Motor Development. Dostęp: http://www.sensoryprocessinginfo/CrisRowan.pdf.[8] Mazurek, M. & Engelhardt, Chr. (2013). Video game use and problem behaviors in boys with autism spectrum disorders. Research in Autism Spectrum Disorders. 7. 316–324. Mazurek, M. O., & Wenstrup, C. (2013). Television, video game and social media use among children with ASD and typically developing siblings. Journal of autism and developmental disorders, 43(6), 1258–1271. [9] Swing, E. L., Gentile, D. A., Anderson, C. A., & Walsh, D. A. (2010). Television and video game exposure and the development of attention problems. Pediatrics, 126(2), 214–221.Pressman, R., Owens, J., Evans, A.& Nemon, M. (2014). Examining the Interface of Family and Personal Traits, Media, and Academic Imperatives Using the Learning Habit Study. The American Journal of Family Therapy. 42. 347-363. Lillard, A. S., & Peterson, J. (2011). The immediate impact of different types of television on young children's executive function. Pediatrics, 128(4), 644–649. [10] Herbert, M. R., & Sage, C. (2013). Autism and EMF? Plausibility of a pathophysiological link - Part I. Pathophysiology : the official journal of the International Society for Pathophysiology, 20(3), 191–209.[11] Belardinelli, C., Raza, M., &Taneli T.(2016). Comorbid Behavioral Problems and Psychiatric Disorders in Autism Spectrum Disorders. Journal of Childhood & Developmental Disorders. 02(11)Mihajlović, G., Hinić, D., Damjanović, A., Gajić, T., & Dukić-Dejanović, S. (2008). Excessive internet use and depressive disorders. Psychiatria Danubina, 20(1), 6–15.Yen, J. Y., Ko, C. H., Yen, C. F., Wu, H. Y., & Yang, M. J. (2007). The comorbid psychiatric symptoms of Internet addiction: attention deficit and hyperactivity disorder (ADHD), depression, social phobia, and hostility. The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 41(1), 93–98.

Univox série spéciale | Gueules de chercheur.e.s EP.2 Paul-Armand Dujardin et Thomas Desmidt. En partenariat avec la Nuit Européenne Des Chercheur.e.s La dépression majeure (MD) est déjà la deuxième cause d'incapacité liée à une maladie (Ferrari et al. 2013), avec une prévalence de 12 à 20% au cours de la vie, affectant des individus de tout âge et classe socio-économique. Environ 30 % des patients sont resistants aux ttt conventionnels, aux ttt medicamenteux, à la psychothérapie. Par ailleurs, le temps de réponse aux ttt médicamenteux peut être longue, et parfois décourageante. A Tours, le CHRU et l'unité mixte de recherche INSERM Ibrain travaille entre autre à mieux comprendre les mécanismes de la dépression et à trouver de nouvelles approches thérapeutique On en parle avec nos deux invités, Paul-Armand Dujardin, ingénieur d'études au CIC-IT, Ultrasons et radiopharmaceutiques ; et Thomas Desmidt, psychiatre, unité de recherche INSERM IBrain. Dans un communiqué de presse en date du 1e septembre 2023, l'INSERM présente l'étude PROTOBRAIN : le MEOPA ou « gaz hilarant » comme une piste thérapeutique serieuse dans le ttt de la dépression resistante. Evidemment, on ne parle pas ici du gaz de siphon de cuisine consommé dans un but récréatif par des adolescents, avec souvent des conséquences neurologiques dramatiques, mais bien d'un protocole de recherche, dont les premiers résultats ont été publiés le 17 aout 2023 dans la révue Molecular Psychiatry. Mais avant d'aboutir à ces résultats, il y a la mise en œuvre pratique du protocole de recherche. Nos deux chercheurs nous donnent un aperçu du travail réalisé en amont de la publication L'étude PROTOBRAIN se poursuit à Tours, Rennes, et Nantes, et si les résultats sont probants, on peut espérer une utilisation du gaz hilarant dans les soins courants d'ici 4 ou 5 ans sous reserve de validation par l'agence nationale de sécurité du médicament Production : Radio Campus Tours Interview et montage : Melissa Wyckhuyse Infos sur les travaux de recherches https://www.univ-tours.fr/recherche/actualite-scientifique/du-gaz-hilarant-pour-le-traitement-de-la-depression-est-ce-vraiment-serieux https://www.nature.com/articles/s41380-023-02217-6 + d'information sur la 13e édition de la Nuit Européenne Des Chercheur.e.s le 29 sept. dans vos villes https://nuitdeschercheurs-france.eu

Univox série spéciale | Gueules de chercheur.e.s EP.2 Paul-Armand Dujardin et Thomas Desmidt. En partenariat avec la Nuit Européenne Des Chercheur.e.s La dépression majeure (MD) est déjà la deuxième cause d'incapacité liée à une maladie (Ferrari et al. 2013), avec une prévalence de 12 à 20% au cours de la vie, affectant des individus de tout âge et classe socio-économique. Environ 30 % des patients sont resistants aux ttt conventionnels, aux ttt medicamenteux, à la psychothérapie. Par ailleurs, le temps de réponse aux ttt médicamenteux peut être longue, et parfois décourageante. A Tours, le CHRU et l'unité mixte de recherche INSERM Ibrain travaille entre autre à mieux comprendre les mécanismes de la dépression et à trouver de nouvelles approches thérapeutique On en parle avec nos deux invités, Paul-Armand Dujardin, ingénieur d'études au CIC-IT, Ultrasons et radiopharmaceutiques ; et Thomas Desmidt, psychiatre, unité de recherche INSERM IBrain. Dans un communiqué de presse en date du 1e septembre 2023, l'INSERM présente l'étude PROTOBRAIN : le MEOPA ou « gaz hilarant » comme une piste thérapeutique serieuse dans le ttt de la dépression resistante. Evidemment, on ne parle pas ici du gaz de siphon de cuisine consommé dans un but récréatif par des adolescents, avec souvent des conséquences neurologiques dramatiques, mais bien d'un protocole de recherche, dont les premiers résultats ont été publiés le 17 aout 2023 dans la révue Molecular Psychiatry. Mais avant d'aboutir à ces résultats, il y a la mise en œuvre pratique du protocole de recherche. Nos deux chercheurs nous donnent un aperçu du travail réalisé en amont de la publication L'étude PROTOBRAIN se poursuit à Tours, Rennes, et Nantes, et si les résultats sont probants, on peut espérer une utilisation du gaz hilarant dans les soins courants d'ici 4 ou 5 ans sous reserve de validation par l'agence nationale de sécurité du médicament Production : Radio Campus Tours Interview et montage : Melissa Wyckhuyse Infos sur les travaux de recherches https://www.univ-tours.fr/recherche/actualite-scientifique/du-gaz-hilarant-pour-le-traitement-de-la-depression-est-ce-vraiment-serieux https://www.nature.com/articles/s41380-023-02217-6 + d'information sur la 13e édition de la Nuit Européenne Des Chercheur.e.s le 29 sept. dans vos villes https://nuitdeschercheurs-france.eu

How Amino Acids Can Balance Your Mood and Safely Detox from SSRIs and Anti-Anxiety Meds with Julia Ross   Julia Ross is a world leader in the use of Nutritional Therapy for the treatment of mood problems, eating disorders, and addictions. After 10 years as a psychotherapist working with individual adults and adolescents, families and groups in a variety of in psychiatric and outpatient settings, Ross began to direct programs. Some of her early achievements included the founding of the San Francisco Bay Area's first programs for food addicts and for drug-addicted adolescents and their families. Julia is the author of The Diet Cure, The Mood Cure, and The Craving Cure; she has been the subject of many articles in publication from Vogue Magazine to The Journal of Molecular Psychiatry. Her own articles have been published in Counselor Magazine, the Journal of the American Psychological Association, the Townsend Letter, Practical Pain Management and elsewhere. She has frequently appeared as an expert on radio, television, and the internet: An NBC special on The Mood Cure's approach to depression was aired several times throughout the U.S.  Julia is now the Director of The Craving Cure Virtual Clinic and The NeuroNutrient Therapy Institute based in Mill Valley, California.   https://www.juliarosscures.com

According to the W.H.O., depression affects about 5% of adults worldwide, or 280 million people, many of whom are women. Symptoms include feeling low and hopeless, guilty, irritable, unable to sleep and sometimes having thoughts about suicide. Depression can affect anyone as a single episode following a challenging time, or can be alternated to manic symptoms in bipolar disorders. We are going to talk only about recurrent depressive disorder, where at least two depressive episodes occur and the condition persists over time. Despite the existence of many effective psychological and medical interventions, many people do not get treated for depression, and it is often found that medication is taken by some for many years, but the root cause of the issue is not lack of serotonin as we have been told for years. ‘There remains no clear evidence that serotonin levels or serotonin activity are responsible for depression, according to a major review of prior research led by UCL scientists. The new umbrella review – an overview of existing meta-analyses and systematic reviews – published in Molecular Psychiatry, suggests that depression is not likely caused by a chemical imbalance, and calls into question what antidepressants do. Most antidepressants are selective serotonin reuptake inhibitors (SSRIs), which were originally said to work by correcting abnormally low serotonin levels. There is no other accepted pharmacological mechanism by which antidepressants affect the symptoms of depression. Many people take antidepressants because they have been led to believe their depression has a biochemical cause, but this new research suggests this belief is not grounded in evidence. (Link to study: https://www.ucl.ac.uk/news/2022/jul/no-evidence-depression-caused-low-serotonin-levels-finds-comprehensive-review) Self-care plays an important role in managing symptoms of depression and promoting overall well-being: doing enjoyable activities, staying connected, exercise, avoiding alcohol and drugs, talking to someone. In my interview with Chloe Jimenez Peters we will hear about her depression story, which started when she was just a teen. Over decades, Chloe went through medication, therapy and shifts in behaviour, and while at medical school she was taught that genetics and chemicals were the only culprits behind disease. But her beliefs were to encounter the reality of the unconscious mind and how it shapes our mental health - even creating depression as a nervous system response to triggers such as trauma. Chloe ended up retraining in RTT, becoming trauma-informed and working with depressed patients who had lost all hope. With her 1 and 2 month programs, depressed clients were able redesign their life and exit the cocoon where they had sheltered for many years. How did this happen? Using hypnosis in combination with NLP, coaching and CBT, which is part of the RTT training that both myself and Chloe have undertaken. After clearing up old beliefs of not being good enough, and reprocessing the past, we can effectively move to the present, stop ruminating the past and see ourselves as the powerful, spiritual being we are - magnificent people with purpose and with all life ahead of us. We hold within us the power to heal, the power to change behaviours we don't like, the power to achieve success like we never dared to dream before. Feel free to ask any questions to myself or to Chloe, by visiting www.franzsidney.com https://chloejimenezpeters.com #rapidtransformationaltherapy #soulpurpose #authenticity #freedom #narcissist #narcissism #narcissisticabuse #narcissistrecovery #trauma #emotionaltrauma #childhoodtrauma #healingtrauma #selflove #selfmastery #abundance #happiness #therapy #coaching #hypnotherapy #rootcausemedicine #spiritualawakening #subconsciousmind #depression  

The Craving Cure with Julia Ross   Julia Ross is a world leader in the use of Nutritional Therapy for the treatment of mood problems, eating disorders, and addictions. After 10 years as a psychotherapist working with individual adults and adolescents, families and groups in a variety of in psychiatric and outpatient settings, Ross began to direct programs. Some of her early achievements included the founding of the San Francisco Bay Area's first programs for food addicts and for drug-addicted adolescents and their families. Julia is the author of The Diet Cure, The Mood Cure, and The Craving Cure; she has been the subject of many articles in publication from Vogue Magazine to The Journal of Molecular Psychiatry. Her own articles have been published in Counselor Magazine, the Journal of the American Psychological Association, the Townsend Letter, Practical Pain Management and elsewhere. She has frequently appeared as an expert on radio, television, and the internet: An NBC special on The Mood Cure's approach to depression was aired several times throughout the U.S. and a CBN special on how amino acid therapies eliminate food cravings generated 50,000 calls to the producers. Julia is now the Director of The Craving Cure Virtual Clinic and The NeuroNutrient Therapy Institute based in Mill Valley, California.   https://www.juliarosscures.com

Is eating ultra-processed foods associated with depression, anxiety, memory problems, and trouble reasoning? An article I read in early May took me down a research rabbit hole and there are a lot of recent studies that say just that: 60% of the American diet is ultra-processed foods and they are causing mental health issues and cognitive decline. Today we're digging into the data and uncovering what defines ultra-processed foods, how much it affects our mental health, and to what extent. Resources and Citations: How Eating Ultraprocessed Foods Can Affect Your Mental Health - The New York Times (nytimes.com) Characterizing Ultra-Processed Foods by Energy Density, Nutrient Density, and Cost - PubMed (nih.gov) Nutrients | Free Full-Text | The Healthfulness of the US Packaged Food and Beverage Supply: A Cross-Sectional Study (mdpi.com) Current Intake of Ultra-Processed Foods in the U.S. Adult Population According to Education-Level and Income | Current Developments in Nutrition | Oxford Academic (oup.com) Cross-sectional examination of ultra-processed food consumption and adverse mental health symptoms - PubMed (nih.gov) Association Between Consumption of Ultraprocessed Foods and Cognitive Decline | Dementia and Cognitive Impairment | JAMA Neurology | JAMA Network Diet and depression: exploring the biological mechanisms of action | Molecular Psychiatry (nature.com) --- Send in a voice message: https://podcasters.spotify.com/pod/show/justgrowsomething/message

Depresia este, la nivel mondial, principalul motiv pentru care se apelează la concediu medical, iar estimările arată că frecvența ei este în continuă creștere, ceea ce înseamnă că va rămâne în continuare o provocare majoră de sănătate. Deși înțelegerea depresiei a fost o prioritate atât pentru știință cât și pentru practică, realitatea este că nu s-au făcut descoperiri majore în adresarea depresiei de mai bine de 50 de ani. Câteva aspecte cunoscute până acum, din studii: Ipoteza conform căreia depresia este rezultatul unor anormalii, dezechilibre chimice din creier are mult mai puțină susținere decât s-a crezut până acum. Mono-terapiile, adică alegerea unei singure linii de tratament al depresiei severe, fie ea medicamentoasă, fie o forma de terapie acreditată au impact limitat. Modificările implicate în bolile inflamatorii intestinale sunt puternic asociate cu sănătatea emoțională și mintală, iar această relație este bidirecțională. Perturbarea sistemului imun moștenit și a celui adaptativ (care sunt în strânsă legătură cu microbiomul) subminează prognosticul favorabil al medicamentației antidepresive Deși sunt la început, cercetările despre rolul psihobioticelor în sănătatea emoțională și mintală au obținut rezultatele cele mai promițătoare despre rolul psihobioticelor în tratarea depresiei (față de alte tulburări, ca cele de anxietate sau cele bipolare, de ex.). Invitatul acestui episod Mind Education Podcast este Dan C. Vodnar , prorector cercetare, USAMV Cluj-Napoca, profesor în cadrul Facultății de Știința și Tehnologia Alimentelor, expert în cadrul Comisiei Europene pentru probleme de bio-economie. Pentru rezultatele de cercetare a fost inclus în top 2% mondial al cercetătorilor științitifici din domeniul științei alimentelor; deține brevete de invenție, unele curs de brevetare; munca de cercetare și inovație este recunoscută internațional, a câștigat medalia de aur de la prestigiosul Salon de Inventică de la Geneva, iar una dintre temele constante de interes din ultimii 10 ani este rolul probioticelor asupra calității vieții. min. 11:31 - Care este rostul psihobiotocelor în adresarea depresiei? min. 14:50 - Există o anumită compoziție, specifică atunci când o persoană se confruntă cu provocări ale sănătății emoționale sau neurologice? min. 20:26 - Care este contribuția geneticii versus cea a mediului în modelarea microbiomului? min. 25:44 - Care este rolul stresului, sau al poluării în a modifica structura microbiomului? min. 35:48 - În relația dintre microbiom și bolile neurologice, are un rol procesul de îmbătrânire? min. 39:08 - Pot fi ajutate, îmbunătățite patologiile neurologice, epilepsia prin modelarea microbiomului? Music: Sergiu Tuhuțiu. Blackmailed Soul Articole (selecție): Beurel, E, Toups, M, Nemeroff CB. (2020). The Bidirectional Relationship of Depression and Inflammation: Double Trouble. Neuron.22;107(2):234-256. doi: 10.1016/j.neuron.2020.06.002. Călinoiu, L.-F.; Ştefănescu, B.E.; Pop, I.D.; Muntean, L.; Vodnar, D.C. (2019). Chitosan Coating Applications in Probiotic Microencapsulation. Coatings;9, 194. https://doi.org/10.3390/coatings9030194 Moncrieff, J., Cooper, R.E., Stockmann, T. et al. (2022). The serotonin theory of depression: a systematic umbrella review of the evidence. Molecular Psychiatry (2022). https://doi.org/10.1038/s41380-022-01661-0

Over the previous 76 episodes, The Radically Genuine Podcast has informed and taken a position on a number of key issues—advocating for those who have been harmed by the mental health system. Dr. Roger McFillin's plea for a psychiatrist to challenge some of those key issues has been answered by Dr. Doug Beech.  Doug Beech, MD, is a psychiatrist that has been in practice in Columbus Ohio for thirty-two years, the last twenty-four in full-time outpatient practice, where he specializes in individual psychotherapy and pharmacologic therapies. We welcome Dr. Beech for an open discussion and to provide alternative viewpoints.Dr Beech

Julia Ross is the author of The Diet Cure, The Mood Cure, and The Craving Cure; she has been the subject of many articles in publication from Vogue Magazine to The Journal of Molecular Psychiatry. Her own articles have been published in Counselor Magazine, the Journal of the American Psychological Association, the Townsend Letter, Practical Pain Management and elsewhere. She has frequently appeared as an expert on radio, television, and the internet: An NBC special on The Mood Cure's approach to depression was aired several times throughout the U.S. and a CBN special on how amino acid therapies eliminate food cravings generated 50,000 calls to the producers. Julia is now the Director of The Craving Cure Virtual Clinic and The NeuroNutrient Therapy Institute based in Mill Valley, California. In todays episode Molly and Clarissa dive a little deeper into the practical application of amino acid therapy with Julia.  In This Episode: Julia shares her Personal/Professional Journey to amino acid/nutritional therapy How addiction treatment was different in the 70s & 80s compared to today? How "frequent junk food assaults" can create "trauma" in the brain The link between stress and cravings The number one cause for carbohydrate cravings More specifics about the protocols for amino acids  What medications to be mindful of with amino acid therapy  Does this intervention work fro eating disorders as well Follow Julia: Julia's Website: https://www.juliarosscures.com/ The Craving Type Questionnaire: https://www.juliarosscures.com/craving-type-questionnaire/ The Craving Cure Virtual Clinic: https://www.juliarosscures.com/craving-eradication/ The content of our show is educational only. It does not supplement or supersede your healthcare provider's professional relationship and direction. Always seek the advice of your physician or other qualified mental health providers with any questions you may have regarding a medical condition, substance use disorder, or mental health concern.  

Julia Ross is the author of The Diet Cure, The Mood Cure, and The Craving Cure; she has been the subject of many articles in publication from Vogue Magazine to The Journal of Molecular Psychiatry. Her own articles have been published in Counselor Magazine, the Journal of the American Psychological Association, the Townsend Letter, Practical Pain Management and elsewhere. She has frequently appeared as an expert on radio, television, and the internet: An NBC special on The Mood Cure's approach to depression was aired several times throughout the U.S. and a CBN special on how amino acid therapies eliminate food cravings generated 50,000 calls to the producers. Julia is now the Director of The Craving Cure Virtual Clinic and The NeuroNutrient Therapy Institute based in Mill Valley, California. In todays episode Julia describes how all her years of work came together and she introduces the concept of craving types and the amino acids that she has tested clinically to help thousands of people reduce and eliminate them with some simple supplementation. Follow Julia: Julia's Website: https://www.juliarosscures.com/ The Craving Type Questionnaire: https://www.juliarosscures.com/craving-type-questionnaire/ The Craving Cure Virtual Clinic: https://www.juliarosscures.com/craving-eradication/ The content of our show is educational only. It does not supplement or supersede your healthcare provider's professional relationship and direction. Always seek the advice of your physician or other qualified mental health providers with any questions you may have regarding a medical condition, substance use disorder, or mental health concern.        

VIDEO: Tulsi Gabbard: Zelenskyy shut down the biggest Ukrainian church in the country (3:18) Tulsi Gabbard destroys Trudeau #trudeaumustgo #canada #chrystiafreeland #tulsigabbard New leak claims FBI grilled Twitter on ‘state propaganda' (4:41) From the frontlines, the USEU/UK war on school playgrounds in Donbass. Eva Bartlett (6:58) Mediterranean diet linked to lower preeclampsia risk Cedars-Sinai Medical Center, December 22, 2022 In a new study evaluating the Mediterranean diet and adverse pregnancy outcomes, investigators from the Smidt Heart Institute at Cedars-Sinai found that women who conceived while adhering to the anti-inflammatory diet had a significantly lower risk of developing preeclampsia during pregnancy. The study, published in the peer-reviewed journal JAMA Network Open, also evaluated the association between the Mediterranean diet and other adverse pregnancy outcomes, including gestational diabetes and hypertension, preterm birth, delivery of a small-for-gestational-age infant, and stillbirth. “This multicenter, population-based study validates that a healthier eating pattern is associated with a lower risk of adverse pregnancy outcomes, the most exciting being a 28% lower risk for preeclampsia,” said Natalie Bello, MD, MPH, senior and corresponding author of the study and director of Hypertension Research in the Smidt Heart Institute. “Importantly, this connection between the Mediterranean diet and lower risk of adverse pregnancy outcomes was seen in a geographically, racially and ethnically diverse population.” Bello also notes that researchers found the association was stronger in women who are traditionally considered to be of advanced maternal age, those 35 or older. Preeclampsia is a serious blood pressure condition that develops during pregnancy and puts stress on the mother's heart. Left untreated, the condition can cause serious complications like weakened kidney and liver function and decreased blood supply to the fetus. In addition to preeclampsia, the risk of gestational diabetes also decreased in women who more closely followed the heart-healthy diet. The study was part of the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be, which enrolled 10,038 women . Of the women enrolled, 7,798 were included in the JAMA Network Open study. Women who were pregnant with their first child were asked to complete a semi-quantitative food frequency questionnaire during their first study visit, which occurred in the first trimester. The questionnaire focused on the women's eating habits during the three months prior to their visit and asked the participants to report their intake of common foods and beverages. Individuals' responses were then categorized into the nine components of a Mediterranean diet—vegetables, fruits, nuts, whole grains, legumes, fish, monounsaturated-to-saturated fat ratio, red and processed meats, and alcohol—to calculate a Mediterranean diet score. The data was compiled, analyzed and studied by researchers and showed: A high Mediterranean diet score was related to 21% lower odds of having any adverse pregnancy outcome, as well as a 28% and 37% lower risk of having preeclampsia/eclampsia and gestational diabetes. (NEXT) Almond findings continue to demonstrate prebiotic promise University of Florida, December 17, 2022 Eating almonds is beneficial to maintaining a healthy gut microbiota composition and improving the diet quality of parents and children suggests a new study. The research is the first to monitor the effects of dietary change on digestive health and immune function in a parent and child and whether this positively affects immunity, inflammation and general health. Writing in Nutrition Research, researchers began by enrolling 29 healthy parent and child pairs in to a 14-week, randomised, controlled, crossover study. Parents and children consumed 1.5 and 0.5 ounces of almonds and/or almond butter, respectively, on a daily basis for three weeks, as part of their usual diet, followed by a 6-week washout period and another 3-week period of following the usual diet with no almonds. Using the Healthy Eating Index (HEI) score—a measure of adherence to recommended dietary guidance—parents and children increased their scores to 61.4, (above national averages of 57.4 for adults 31-50 years and 54.9 for children 4-8 years). HEI scores also increased for fatty acids, total protein, seafood and plant protein and decreased for fruit and empty calories. When eating almonds, participants also consumed more vitamin E and magnesium, two nutrients lacking in the majority of adult's and children's diets. Almond consumption also seemed to change gut bacteria levels in subjects. Although the children consumed one-third of the amount of almonds compared to adults, microbiota was affected to a greater extent in their bodies. No specific changes in immune markers were noted. Last year, NutraIngredients reported on a study in which fibre-rich almonds and their skin may selectively boost the populations of Bifidobacterium spp. and Lactobacillus spp in the gut. The study suggested that populations of these bacteria were enhanced after six weeks of consuming almonds or almond skins. (NEXT) Probiotic bacteria found in fermented foods might help dispel bad breath Sichuan University (China), December 21, 2022 Probiotic bacteria usually found in fermented foods, such as yoghurt, sourdough bread, and miso soup, might help dispel the embarrassment of persistent bad breath (halitosis), finds a pooled data analysis of the available evidence, published in the open access journal BMJ Open. Lactobacillus salivarius, Lactobacillus reuteri, Streptococcus salivarius, Weissella cibaria, taken in the form of supplements in this study, may help freshen the breath, but more good quality research is needed, say the researchers. Volatile sulphuric compounds are the main cause of persistent bad breath. These compounds are produced by mouth bacteria as a result of bacterial mixing and food debris associated with poor gum and dental hygiene. Options used to tackle the problem include mouthwashes, chewing gums, teeth scaling and tongue scraping. Emerging evidence suggests that probiotic bacteria might offer a simpler alternative. To explore this further, and find out how long any such effects might last, the researchers trawled research databases for relevant randomised clinical trials published up to February 2021. Probiotics may inhibit the decomposition of amino acids and proteins by anaerobic bacteria in the mouth, so curbing the production of smelly by-products, the researchers explain. (NEXT) War metaphors for cancer hurt certain prevention behaviors University of Michigan, December 15, 2022 It's not unusual for people to use war metaphors such as “fight” and “battle” when trying to motivate patients with cancer. But a University of Michigan study indicates that using those words can have an unintended negative effect. David Hauser, a U-M doctoral student in psychology, and colleague Norbert Schwarz, found in three studies that exposure to metaphoric language relating cancer to an enemy significantly lessens the extent to which people consider cancer-prevention behaviors. “Hearing metaphoric utterances is enough to change the way we think about a concept,” said Hauser, the study's lead investigator. “When we hear the phrase ‘win the battle against cancer,' it forces us to think of cancer as if it's an enemy that we are at war with.”These metaphors emphasize power and taking aggressive actions toward an enemy. However, the bulk of cancer prevention behaviors–such as curbing alcohol intake, salty foods and smoking–involve limitation and restraint. None of them fit with an enemy metaphor that promotes power and aggression, the researchers said. “Hence, enemy metaphors de-emphasize this subset of beneficial prevention behaviors and hurts people's willingness to engage in them,” he said. In one study, the authors asked participants to list cancer-prevention behaviors they would be willing to undertake. For one group of participants, the request contained metaphors relating cancer to an enemy (“What things would you do to fight against developing cancer?”). For a second group, the request contained no metaphors. The group exposed to the enemy metaphor listed significantly less limitation-related prevention behaviors. “This suggests that simply seeing war metaphors for cancer diminishes the extent to which these behaviors come to mind,” Hauser said. In another study, 313 participants read one of two health information passages about colorectal cancer. One passage contained metaphors relating cancer to an enemy (“This disease involves an enemy uprising of abnormal cellular growth in the large intestine.”), whereas the second passage contained no enemy metaphors. Participants then rated the extent to which they intended to engage in various prevention, screening and treatment behaviors. Those who read the enemy metaphor passage had less intention to engage in limitation-related prevention behaviors (such as limiting red meat intake or excessive alcohol consumption) than the participants who read the second passage. “Enemy metaphoric language for cancer diminishes people's intentions for these types of prevention behaviors,” Schwarz said. “Importantly, these negative effects of enemy metaphors on prevention behaviors are not accompanied by a positive effect on intentions to undertake screening or treatment behaviors.” War and enemy metaphors are the most common metaphors found in science journalism about cancer, and they pervade public discourse about the disease.”Fight and battle are actually among the top 10 verbs used to describe cancer,” Hauser said. “Constant exposure to even minor metaphorical utterances may be enough to make enemy metaphors for cancer a powerful influence on public health–with unfortunate side-effects.” (NEXT) More proof that cannabis is an anti-aging powerhouse to rapidly restore memory performance of older mice Hebrew University Jerusalem & University of Bonn (Germany), December 14, 2022 Scientists from The Hebrew University of Jerusalem and the University of Bonn teamed up to examine the potential brain benefits of cannabis in mice. This amazing study is years in the making, with the researchers having built a strong body of evidence on the brain benefits of THC. To conduct their study, researchers administered a small amount of THC, derived from cannabis, to mice aged two, twelve and 18 months old for the course of one month. Some mice were given a placebo. As sources explain, mice have very short life spans and show substantial cognitive deficiencies at just 12 months of age. Afterwards, the mice were subjected to a battery of tests to gauge their learning capacity and memory. Incredibly, the team found that older mice treated with cannabis displayed cognitive function that was as good as the youngest control subjects. As reported by The Hebrew University of Jerusalem: Mice that were only given a placebo displayed natural age-dependent learning and memory losses. In contrast, the cognitive functions of the animals treated with cannabis were just as good as the two-month-old control animals. “The treatment completely reversed the loss of performance in the old animals,” reported Prof. Andreas Zimmer from the Institute of Molecular Psychiatry at the University of Bonn and member of the Cluster of Excellence ImmunoSensation. In past studies, the team found that brain aging is accelerated when THC receptors are absent, prompting them to investigate further. In the brain, THC acts very similarly to the cannabinoids naturally produced by the body. “With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces. When the activity of the cannabinoid system declines, we find rapid aging in the brain,” Prof. Zimmer commented. Treating the mice with THC yielded incredibly impressive epigenetic changes in their brains, and the number of links between neurons dramatically increased, as well. “It looked as though the THC treatment turned back the molecular clock,” Zimmer commented. (NEXT) Brussels Sprouts Have As Much Vitamin C As Oranges – And Plenty Of Other Health Benefits Quadram Institute, December 22, 2022 For many people, Christmas dinner is not complete without a side helping of Brussels sprouts. Indeed, they are Britain's favourite Christmas dinner vegetable. But if you're not a convert, perhaps these health benefits will convince you to give them a second chance. Sprouts belong to the wholesome family of cruciferous or brassica vegetables, including cabbage, kale and broccoli. As with all brassica, Brussels sprouts are packed with fibre, which is good for keeping the beneficial bacteria in your gut happy. They also provide essential minerals, such as potassium and calcium, to keep your muscle and bones healthy. They are rich in vitamins K and C, supporting a healthy immune system and bones. Pound for pound, you'll get more vitamin C from them when eaten raw than from oranges. Cooked Brussels sprouts still contain vitamin C, though – about the same pound for pound as you'd get from orange juice and raw oranges.Most importantly, Brussels sprouts are rich in a wide range of natural chemicals, such as carotenoids and polyphenols, that have been linked to good health. They are particularly abundant in sulphur-containing compounds called glucosinolates. Several scientific studies have shown that these sulphurous compounds are potent antioxidants that can promote health by preventing cell damage. Several studies have also shown that consuming more of these glucosinolates from cruciferous vegetables, including Brussels sprouts, broccoli, kale and cabbage, are associated with a reduced risk of developing a wide range of cancers. Research continues collecting more evidence of their benefits, but the best advice to keep in mind is to try to consume roughly five portions of brassica vegetables weekly and to vary the options.

Videos: Member of The FDA Vax Panel Said “We Are Killing More People Than We Are Saving With The Shots” RFK : The Real Anthony Fauci Clip (1st clip 5:50 – 2nd Clip 4:37) Dr Shoemaker – C19 vaxx – lethal short and long term 10/22/22 (13:00) Clare Daly Latest Top 7 Contributions in the EU. (Start @ 4:32) Neil Oliver: We are expected to forget those promising to fix the disaster caused it (10:28) MASSIVE GLACIER MELTDOWN THREATENS CIVILIZATION | Countdown to Armageddon (7:42) Chlorophyllin shows promise for inflammatory bowel disease Sichuan University (China) & Cedars Sinai Medical Center, October 28 2022.  The August 2022 issue of the American Journal of Physiology Gastrointestinal and Liver Physiology reported research which found that supplementation with chlorophyllin suppressed intestinal inflammation in a mouse model of inflammatory bowel disease (IBD).  Chlorophyllin is a water-soluble derivative of chlorophyll, the pigment that gives green plants their color. “Consuming green-colored vegetables or green pigment supplement such as chlorophyllin might help people with inflammatory bowel disease,” senior author Xiaofeng Zheng, PhD, of Sichuan University West China Hospital in Chengdu, China predicted.  Current treatments for inflammatory bowel diseases include immunosuppressant medications and surgery, both of which are associated with potentially serious adverse effects. “The study was designed to determine the effect of safe agents that are easily available to have a beneficial effect in inflammatory bowel disease,” commented report coauthor Stephen J. Pandol, MD, of Cedars Sinai Medical Center in Los Angeles. The team induced colitis in mice by administering dextran sulfate sodium. They found that supplementing the animals' diets with chlorophyllin or directly administering the compound suppressed intestinal inflammation and downregulated disease-associated autophagy in the intestine.  “What we found in the study was that the agent used, chlorophyllin, would inhibit the inflammation and tissue damage that occurs in an experimental model of colitis,” Dr Pandol commented. “In this case it was in a mouse model. The results were promising in an experimental model, and those can justify a clinical trial.” Curcumin Prodrug Shows Promise As Cancer Treatment Without Toxic Side Effects Kyoto University (Japan), October 30, 2022 Curcumin, the biologically active compound found in turmeric, has shown lots of promise in clinical cancer research. A new study from Kyoto University adds more evidence that supports its use in clinical-care settings. Researchers are developing a curcumin prodrug called TBP1901 that demonstrates anti-tumor effects without adverse toxicities. Curcumin is an appealing compound for oncology researchers, as many current pharmacological treatments lead to significant side effects in patients. Thus far, anecdotal findings report strong efficacy when taken orally among cancer patients. However, until this recent development, curcumin's low bioavailability and instability has put limitations on its clinical use. Kanai and team have maneuvered their way around this by successfully identifying the enzyme GUSB, which may activate curcumin to increase its bioavailability. The enzyme plays a crucial role in TBP1901 conversion to curcumin. However, the research team hypothesized that the conversion wouldn't be observable in mice with genetically-weakened GUSB enzyme. Further, they were able to confirm through analysis with CRISPR-Cas9 screening that curcumin may also have additional specific therapeutic targets. “The high conversion rate of TBP1901 to curcumin in bone marrow warrants its clinical application for diseases growing in the marrow like multiple myeloma and leukemia,” states Kanai. Now that scientists have begun to crack the code with curcumin, the cancer field may start to put things into motion as more targets and enzymatic processes are explained.  Study Reveals How Turmeric Inhibits Pancreatic Cancer Cell Growth University of California Los Angeles, October 23, 2022 Pancreatic cancer is one of the most deadly forms of cancer around. While treatment is often considered futile in this highly lethal form of cancer, a new study indicates a turmeric extract could provide a reasonable chemotherapy alternative. Research published in the peer-reviewed medical journal Anticancer Research found liposomal curcumin was able to inhibit pancreatic cancer cell proliferation in vitro and when administered to mice three times a week for four weeks, it was able to suppress tumor growth when compared with control groups. Liposomal curcumin is curcumin delivered by encapsulation in liposomes, or a prepared carrier with a lipd (fat) layer. Because curcumin is fat soluble and is resistant to water solubility, this liposomal vehicle increases its bioavailability, sending it through a barrier in the liver that would normally block it. The study used a dosage of 20 mg/kg of the liposomal curcumin, an amount that would be the equivalent of 1,360 mg for a 150 lb. adult. The study abstract concludes: “These data clearly establish the efficacy of liposomal curcumin in reducing human pancreatic cancer growth in the examined model,” concluded the researchers. “The therapeutic curcumin-based effects, with no limiting side-effects, suggest that liposomal curcumin may be beneficial in patients with pancreatic cancer.” One study published in the journal PLoS One found that curcumin has the power to inhibit the growth of esophageal cancer cell lines, while other research from UCLA actually found curcumin to decrease brain tumor size by a whopping 81%. Fermented foods and fiber may lower stress levels, says new study APC Microbiome Ireland & University College Cork, October 28, 2022 When it comes to dealing with stress, we're often told the best things we can do are exercise, make time for our favorite activities or try meditation or mindfulness. But the kinds of foods we eat may also be an effective way of dealing with stress, according to research published by me and other members of APC Microbiome Ireland. Our latest study, now published in Molecular Psychiatry, has shown that eating more fermented foods and fiber daily for just four weeks had a significant effect on lowering perceived stress levels.  The mechanisms underpinning the effect of diet on mental health are still not fully understood. But one explanation for this link could be via the relationship between our brain and our microbiome (the trillions of bacteria that live in our gut). It means that the emotional and cognitive centers in our brain are closely connected to our gut. To test this, we recruited 45 healthy people with relatively low-fiber diets, aged 18–59 years. More than half were women. The participants were split into two groups and randomly assigned a diet to follow for the four-week duration of the study. Around half were assigned a diet  which would increase the amount of prebiotic and fermented foods they ate. This is known as a “psychobiotic” diet, as it included foods that have been linked to better mental health. They were told they should aim to include 6–8 servings daily of fruits and vegetables high in prebiotic fibers (such as onions, leeks, cabbage, apples, bananas and oats), 5–8 servings of grains per day, and 3–4 servings of legumes per week. They were also told to include 2–3 servings of fermented foods daily (such as sauerkraut, kefir and kombucha). Participants on the control diet only received general dietary advice, based on the healthy eating food pyramid.  Intriguingly, those who followed the psychobiotic diet reported they felt less stressed compared with those who followed the control diet. There was also a direct correlation between how strictly participants followed the diet and their perceived stress levels, with those who ate more psychobiotic foods during the four-week period reporting the greatest reduction in perceived stress levels. Interestingly, the quality of sleep improved in both groups—though those on the psychobiotic diet reported greater improvements in sleep. Other studies have also shown that gut microbes are implicated in sleep processes, which may explain this link.  The psychobiotic diet only caused subtle changes in the composition and function of microbes in the gut. However, we observed significant changes in the level of certain key chemicals produced by these gut microbes. Some of these chemicals have been linked to mental health, which could potentially explain why participants on the diet reported feeling less stressed. Sedentary lifestyle and sugary diet more detrimental to men, study finds University of Missouri, October 27, 2022 A new study from the University of Missouri School of Medicine is the first evidence in humans that short-term lifestyle changes can disrupt the response to insulin of blood vessels. It's also the first study to show men and women react differently to these changes. Vascular insulin resistance is a feature of obesity and type 2 diabetes that contributes to vascular disease. Researchers examined vascular insulin resistance in 36 young and healthy men and women by exposing them to 10 days of reduced physical activity, cutting their step count from 10,000 to 5,000 steps per day. The participants also increased their sugary beverage intake to six cans of soda per day.  The results showed that only in men did the sedentary lifestyle and high sugar intake cause decreased insulin-stimulated leg blood flow and a drop in a protein called adropin, which regulates insulin sensitivity and is an important biomarker for cardiovascular disease.  “These findings underscore a sex-related difference in the development of vascular insulin resistance induced by adopting a lifestyle high in sugar and low on exercise,” said Manrique-Acevedo.  “To our knowledge, this is the first evidence in humans that vascular insulin resistance can be provoked by short-term adverse lifestyle changes, and it's the first documentation of sex-related differences in the development of vascular insulin resistance in association with changes in adropin levels.”  Spearmint can significantly improve memory, concentration, and brain function St Louis University School of Medicine,  October 25, 2022 Around 64 percent of Americans start their day with a cup of coffee (or several). And, many health article mention that this popular beverage can actually improve memory? But, does it really?  And, is there a healthy alternative? The caffeine in coffee causes a brain release of noradrenaline along with an energy boost and cognitive stimulation. However, this is inevitably followed shortly by a “caffeine crash” as the noradrenaline is depleted. Research is showing there's a more effective alternative to caffeine and it's called spearmint. Long used medicinally for its stimulating and uplifting effects, it can provide a healthier and more reliable energy boost. Even better, spearmint has also been found to improve memory, sharpen concentration and support overall brain health. Research shows spearmint dramatically improves brain function in older individuals The benefits of spearmint are particularly beneficial for cognitive functioning. It offers an enticing combination of relaxation as well as an almost immediate boosting of cognitive function. Two studies confirm and quantify the powers of spearmint's ability to support brain health and boost memory. The study results also showed improvements to concentration, attention span, planning capacity and overall brain functioning. The subjects took memory and cognition tests that assessed their ability to concentrate, pay attention and plan. A single dose of spearmint extract showed significant improvements within the four hours following the dose. At the four hour mark, participants showed a stunning improvement in their memory performance ranging from 46 percent to 121 percent. Planning abilities improved by 39 percent four hours after taking the spearmint extract. Long-term tests after the 30-day study period showed significant overall improvements in all areas. Reasoning abilities improved by 35 percent, and concentration and attention were 125 percent higher. Planning capacity was better by 48 percent. Another spearmint study published in the journal Neurology looked at 90 subjects with an average age of 59. All participants showed age-associated memory impairment at the study outset. Subjects received either 600 mg or 900 mg of spearmint extract daily. They all showed dramatic improvements in spacial working memory as well as their sleep patterns. Other health benefits of spearmint include improved digestion and relief from sore throat, toothache, cramps, arthritis symptoms, headache, fatigue and the common cold.

In the arena of political discourse, many can regard political commentator Bill Maher as an influential figure in mainstream television. Known for combining politics and comedy, Bill Maher has never shied away from controversy. However, in recent years, many on the political left have noticed a swift change in his rhetoric. Now filled with misinformation about medical science, a recurrent theme that has become more apparent since COVID-19 policies were implemented in the U.S. In today's episode, we assess the logical fallacies in Bill Maher's assessment of vaccines, anti-depressants, and medical science in his podcast Club Random with Bill Maher ft Aaron Rodgers. FacebookThe Social Chemist | FacebookInstagramThe Social Chemist (@socialchemistig) • Instagram photos and videosReferencesAaron Rodgers | Club Random with Bill Maher - Club Random with Bill Maher | Podcast on SpotifyThe serotonin theory of depression: a systematic umbrella review of the evidence | Molecular Psychiatry (nature.com)The Serotonin Fixation: Much Ado About Nothing New (psychiatrictimes.com)Psychosurgery for schizophrenia: history and perspectives - PMC (nih.gov)Merck ordered to pay $321 million in criminal Vioxx probe | ReutersU.S. Pharmaceutical Company Merck Sharp & Dohme Sentenced in Connection with Unlawful Promotion of Vioxx | OPA | Department of JusticeRecommended Social Chemist EpisodesThe Conspiratorial Mindset of Dr. Peter McCullough (buzzsprout.com)The Transactional Relationship Between Conspiracy Theory Producer & Consumer (buzzsprout.com)

VIDEO: The U.S. secret in Syria EXPOSED in new hidden camera footage | Redacted with Clayton Morris (12:03) The Conservatives Made Everything in Britain Worse – Johnatan Pie  (6:40) Neil Oliver: Persuading generations of children they are a plague upon the earth is unforgivable – 12:27   Purple potato may pack cancer prevention punch – even after cooking Pennsylvania State University, September 1, 2022 Anthocyanin compounds found in purple potatoes may help in the prevention of certain types of cancer, even after cooking, say researchers. The new data, published in the Journal of Nutritional Biochemistry, tested the potential for anthocyanin-containing purple potatoes to block the growth of cancer tumours, even when they have been cooked – after previous research suggested that the polyphenols found in purple potatoes (PP) may help to battle cancer. Led by Venkata Charepalli from Pennsylvania State University, the team used laboratory tests including in vitro cell line investigations and animal modelling to test how PP impacted colon cancer growth, and in particular, colon cancer stem cells (CSCs), which have previously been suggested to be target by dietary bioactives such as curcumin. The team reported that their data from in vitro and mouse models suggests that baked purple-fleshed potatoes suppressed the growth of colon cancer tumours by targeting the cancer's stem cells. They added that there may be several substances in purple potatoes that work simultaneously, and on multiple pathways, to help kill the colon cancer stem cells, including anthocyanins and chlorogenic acid, and resistant starch. “Our earlier work and other research studies suggest that potatoes, including purple potatoes, contain resistant starch, which serves as a food for the gut bacteria, that the bacteria can covert to beneficial short-chain fatty acids such as butyric acid,” said study senior author Professor Jairam Vanamal – also of Penn State. “The butyric acid regulates immune function in the gut, suppresses chronic inflammation and may also help to cause cancer cells to self-destruct.” Boosting physical activity and curbing sitting time are highly likely to lower breast cancer risk Breast Cancer Association Consortium (UK), September 6, 2022 Boosting physical activity levels and curbing sitting time are highly likely to lower breast cancer risk, finds research designed to strengthen proof of causation and published online in the British Journal of Sports Medicine. The findings were generally consistent across all types and stages of the disease, reveals the Mendelian randomization study, prompting the researchers to recommend a stronger focus on exercise as a way of warding off breast cancer. Mendelian randomization is a technique that uses genetic variants as proxies for a particular risk factor—in this case lifelong physical activity levels/sedentary behavior—to obtain genetic evidence in support of a causal relationship. Observational studies show that physical inactivity and sedentary behavior are linked to higher breast cancer risk, but proving they cause breast cancer is another matter. The researchers included data from 130,957 women of European ancestry: 69, 838 of them had tumors that had spread locally (invasive); 6667 had tumors that hadn't yet done so (in situ); and a comparison group of 54,452 women didn't have breast cancer. Researchers estimated overall breast cancer risk, according to whether the women had or hadn't gone through the menopause; and by cancer type (positive for estrogen or progesterone, or HER-2, or positive/negative for all 3 hormones), stage (size and extent of tumor spread), and grade (degree of tumor cell abnormality). These case-control groups comprised: 23,999 pre/peri-menopausal women with invasive breast cancer and 17,686 women without; 45,839 postmenopausal women with breast cancer and 36,766 without. Analysis of the data showed that a higher overall level of genetically predicted physical activity was associated with a 41% lower risk of invasive breast cancer, and this was largely irrespective of menopausal status, tumor type, stage, or grade. Similarly, genetically predicted vigorous physical activity on 3 or more days of the week was associated with a 38% lower risk of breast cancer, compared with no self-reported vigorous activity. These findings were consistent across most of the case groups. Finally, a greater level of genetically predicted sitting time was associated with a 104% higher risk of triple negative breast cancer. These findings were consistent across hormone-negative tumor types. How the mind sharpens the senses Ruhr University Bochum (Germany), August 27, 2022 A study conducted with experienced scholars of Zen-Meditation shows that mental focussing can induce learning mechanisms, similar to physical training. Researchers at the Ruhr-University Bochum and the Ludwig-Maximilians-University München discovered this phenomenon during a scientifically monitored meditation retreat. The journal Scientific Reports, from the makers of Nature, has now published their new findings on the plasticity of the brain. The participants were all Zen-scholars with many years of meditation practice. The retreat was held in complete silence, with at least eight hours of meditation per day. All participants practiced their familiar meditation, which is characterized by a non-specific monitoring of thoughts and surroundings. Additionally, some participants applied a special finger-meditation for two hours per day, during which they were asked to specifically focus on their right index finger and become aware of spontaneously arising sensory percepts in this finger. Subsequent assessment of the group that practiced finger-meditation showed a significant improvement in the tactile acuity of the right index and middle finger. A control group that had maintained their familiar meditation practice for the whole time, showed no changes in tactile acuity. In order to assess the sense of touch quantitatively, researchers measured the so-called “two-point discrimination threshold”. This marker indicates how far apart two stimuli need to be, in order to be discriminated as two separate sensations. After the finger meditation, the performance improved on average by 17 percent. By comparison, tactile acuity of the visually impaired is 15 to 25 percent above that of typical sighted individuals, because their sense of touch is used so intensively to make up for the reduced visual information. Hence, the changes induced by meditation are comparable to those achieved by intense long-term training. It is known for long that extensive training induces neuroplasticity, which denotes the ability of the brain to adapt and restructure itself, thereby improving perception and behavior. Recently, the group of neuroscientists of the Neural Plasticity Lab headed by Hubert Dinse has shown that these processes can be initiated even without training by mere exposure to passive stimulation, which was translated only recently into a stimulating glove, which is used as therapeutical intervention in stroke patients. The fact that merely mental states without any physical stimulation can improve perception has now been shown for the first time. “The results of our study challenge what we know about learning mechanisms in the brain. Our concept of neuroplasticity must be extended, because mental activity seems to induce learning effects similar to active stimulation and physical training,” Dinse suggests. Elderberry extract may improve obesity inflammation University of Connecticut , September 1, 2022 Black elderberry extract may improve obesity-related metabolic disturbances like triglyceride (TAG) levels, inflammation and insulin resistance, research in mice finds. The researchers from the University of Connecticut in the US said dietary anthocyanins had been shown to reduce inflammation in animal models and to improve obesity-related complications – and black elderberry (Sambucus nigra) was one of the richest sources of these types of flavonoids. “Overall, black elderberry extract appeared to attenuate systemic inflammation and insulin resistance that occurs with diet-induced obesity in this mouse model, but further research is warranted on black elderberry consumption and effects in humans,” they wrote in the British Journal of Nutrition. Mice were fed either a low-fat diet, high-fat lard-based diet, a high-fat diet with 0.25% of the extract or a high-fat with 1.25% of the extract for a period of 16 weeks. The black elderberry extracts amounted to an anthocyanin dose of 20–40 mg per kg of body weight for the 0.25% group and 100–200 mg for the 1.25% group. After 16 weeks both extract groups had significantly lower liver weights, serum TAG and serum monocyte chemoattractant protein-1 – a serum marker linked to cardiovascular disease and diabetes – compared to the group given the high fat diet alone. Liver weights were about 13% lower in both extract groups compared to the group given the high fat diet alone. “Obese individuals have shortened life expectancies; however, they do not typically die of obesity itself but rather obesity-related comorbidities, such as cardiovascular disease, diabetes and certain types of cancers,” they said. They said inflammation as a result of adipose fat and excessive accumulation of ectopic lipid in tissues was thought to be a key underlying cause of these obesity-related comorbidities, meaning methods that target and lower inflammation could be effective at preventing obesity-related conditions. First Ground Breaking Study Shows How Rhodiola Rosea Protects People From Viral Infections Appalachian State University August 26, 2022 Also known as arctic root or golden root, Rhodiola Rosea has already been clinically shown to stimulate serotonin, norepinephrine and dopamine activity, and support healthy neurotransmitter balance, but human trials have now shown the the herb protects against viral infection. A 2002 review in HerbalGram, the journal of the American Botanical Council, reported that numerous studies of rhodiola in both humans and animals have indicated that it helps prevent fatigue, stress, and the damaging effects of oxygen deprivation. Evidence also suggests that it acts as an antioxidant, enhances immune system function, and can increase sexual energy. Rhodiola's efficacy was confirmed in a 2011 review of 11 placebo-controlled human studies. The reviewers considered studies that all had study designs rated as moderate to good quality, and the analysis of their combined data concluded that rhodiola might have beneficial effects on physical performance, mental performance, and certain mental health conditions. Nieman's study “Rhodiola rosea exerts antiviral activity in athletes following a competitive marathon race,” which was published July 31 in Frontiers in Nutrition, is the first to show anti-viral activity. In his study, 48 marathon runners participating in the 2012 Thunder Road Marathon in Charlotte were randomly divided into two groups that ingested either 600 milligrams of Rhodiola rosea or a placebo for a month before the race. Blood samples were collected the day before the marathon and 15 minutes and 1.5 hours post-race. Initial studies found no impact on inflammation and oxidative stress. Additional studies used an in vitro assay to measure the ability of the polyphenolic compounds to protect the cells against Vesicular stomatitis virus. The results demonstrated that Rhodiola rosea delayed viral infection for up to 12 hours after the marathon. Nieman was the first scientist to find that marathon runners are prone to viral illnesses such as upper respiratory tract infections after competing. This discovery motivated him to research plant-based compounds that could prevent infection and enhance recovery and overall athletic performance. Since Rhodiola rosea administration appears to impact central monoamine levels, it might also provide benefits and be the adaptogen of choice in clinical conditions characterised by an imbalance of central nervous system monoamines. It also suggests that research in areas such as seasonal affective disorder, fibromyalgia, and chronic fatigue syndrome, among others, is warranted. “Basically after heavy exertion, bacteria and viruses can multiply at a higher rate than normal due to factors in the serum like stress hormones and inflammatory cytokines,” Nieman said. “This is why runners are six times more likely to get sick after a marathon. We showed that in those who used Rhodiola rosea the viruses could not multiply, meaning it was acting as a countermeasure.” Rhodiola both stimulates and protects the immune system by reinstating homeostasis (metabolic balance) in the body. It also increases the natural killer cells (NK) in the stomach and spleen. This action may be due to its ability to normalise hormones by modulating the release of glucocorticoid into the body. How does nature nurture the brain? Max Planck Society, September 6, 2022 After a 60-minute walk in nature, activity in brain regions involved in stress processing decreases. This is the finding of a recent study by the Lise Meitner Group for Environmental Neuroscience at the Max Planck Institute for Human Development, published in Molecular Psychiatry. Living in a city is a well-known risk factor for developing a mental disorder, while living close to nature is largely beneficial for mental health and the brain. A central brain region involved in stress processing, the amygdala, has been shown to be less activated during stress in people who live in rural areas, compared to those who live in cities, hinting at the potential benefits of nature. “But so far the hen-and-egg problem could not be disentangled, namely whether nature actually caused the effects in the brain or whether the particular individuals chose to live in rural or urban regions,” says Sonja Sudimac, predoctoral fellow in the Lise Meitner Group for Environmental Neuroscience and lead author of the study. To achieve causal evidence, the researchers from the Lise Meitner Group for Environmental Neuroscience examined brain activity in regions involved in stress processing in 63 healthy volunteers before and after a one-hour walk in Grunewald forest or a shopping street with traffic in Berlin using functional magnetic resonance imaging (fMRI). The results of the study revealed that activity in the amygdala decreased after the walk in nature, suggesting that nature elicits beneficial effects on brain regions related to stress. “The results support the previously assumed positive relationship between nature and brain health, but this is the first study to prove the causal link. Interestingly, the brain activity after the urban walk in these regions remained stable and did not show increases, which argues against a commonly held view that urban exposure causes additional stress,” explains Simone Kühn, head of the Lise Meitner Group for Environmental Neuroscience. The authors show that nature has a positive impact on brain regions involved in stress processing and that it can already be observed after a one-hour walk. This contributes to the understanding of how our physical living environment affects brain and mental health. Even a short exposure to nature decreases amygdala activity, suggesting that a walk in nature could serve as a preventive measure against developing mental health problems and buffering the potentially disadvantageous impact of the city on the brain.

Luísa Lopes é neurocientista e dedica-se ao estudo dos mecanismos que causam o envelhecimento cognitivo precoce, em particular ao nível da memória. A convidada é actualmente coordenadora do grupo de investigação em “neurobiologia do envelhecimento e doença” no Instituto de Medicina Molecular e Professora Convidada na Faculdade de Medicina da Universidade de Lisboa.  -> Apoie este projecto e faça parte da comunidade de mecenas do 45 Graus em: 45graus.parafuso.net/apoiar _______________ Índice da conversa: (5:59) Como o nosso cérebro envelhece — e porque não acontece igual em toda a gente. | Mais educação = envelhecimento mais lento | Ressonância magnética funcional | Blue zones | A importância do sono. Estatísticas de sono em Portugal. As crianças. | Diminuição da incidência da demência nas últimas décadas.  (23:29) Relação com o envelhecimento sistémico do corpo. | O papel da oxidação. | Organóides  (39:09) Por onde começa o envelhecimento: neurónios vs sinapses | O hipocampo e o estranho caso dos soldados da guerra do Iraque  (49:07) O que distingue o envelhecimento normal do patológico (neurodegenerativo)? E porque afecta sobretudo o hipocampo? | Parkinson vs Alzeimer (57:52) Tratamentos para doenças neurodegenerativas | Causas últimas: danos no genoma; perda de irrigação sanguínea (1:06:55) Tratamentos de ponta: transfusão de sangue de indivíduos novos (paper). | Patient H.M. (1:15:19) Os benefícios da cafeína. Estudo citado (estudo, notícia) (1:20:04) Livro recomendado: O Homem que Confundiu a Mulher com um Chapéu, de Oliver Sacks _______________ Todos sabemos que, infelizmente, com a idade vamos perdendo gradualmente capacidade cognitiva, desde a memória à capacidade de aprender coisas novas. Mas a experiência diz-nos também que existe muita variabilidade entre as pessoas: há quem numa idade avançada se mantenha grande acuidade intelectual, e continue inclusive a trabalhar, mesmo em trabalhos criativos e desafiantes. E, no sentido contrário, há pessoas em que o envelhecimento cognitivo é acelerado e surge prematuramente, por norma associado a doenças neurodegenerativas. Por isso, é provável que todos nós em algum momento nos tenhamos perguntado: porque é que o nosso cérebro envelhece? É simplesmente uma consequência do envelhecimento geral do corpo? E, já agora, será possível evitar sermos assolados por doenças de envelhecimento cognitivo prematuro e, além disso, abrandar o mais possível o envelhecimento natural?  Foram estas e outras perguntas que fiz à convidada deste episódio, a neurocientista Luísa Lopes. Começámos por falar sobre o que acontece exactamente no nosso corpo (e no cérebro em particular) que causa a diminuição de funções cognitivas. Falámos dos neurónios (as células fundamentais do cérebro, de dendrites (o imenso conjunto de ramos que liga um neurónio a outros neurónios) e de sinapses (a ponta desses ramos, onde ocorre a transferência de informação para o outro neurónio). Falámos também sobre que hábitos devemos ter para retardar esse processo, como dormir bem, fazer exercício, comer bem, manter a mente activa e -- o que pode ser menos óbvio -- socializar. Discutimos também o que distingue as doenças neurodegenerativas do envelhecimento normal, e os tratamentos que existem para elas -- bem como das suas limitações.  Mas dormir bem, comer bem, fazer exercício não só dá trabalho como apenas serve para adiar o problema; o que gostaríamos todos era de poder reverter o envelhecimento. Por isso, no final, falámos também de alguns tratamentos revolucionários (mas também ainda pouco certos e com algumas barreiras éticas, como normalmente acontece); por exemplo, experiências recentes feitas com ratos em que se fez a transfusão de sangue de um animal novo num velho, conseguindo com isso reverter o envelhecimento cognitivo.  Foi uma conversa bem interessante. _______________ Obrigado aos mecenas do podcast: Julie Piccini, Ana Raquel Guimarães Galaró family, José Luís Malaquias, Francisco Hermenegildo, Nuno Costa, Abílio Silva, Salvador Cunha, Bruno Heleno, António llms, Helena Monteiro, BFDC, Pedro Lima Ferreira, Miguel van Uden, João Ribeiro, Nuno e Ana, João Baltazar, Miguel Marques, Corto Lemos, Carlos Martins, Tiago Leite Tomás Costa, Rita Sá Marques, Geoffrey Marcelino, Luis, Maria Pimentel, Rui Amorim, RB, Pedro Frois Costa, Gabriel Sousa, Mário Lourenço, Filipe Bento Caires, Diogo Sampaio Viana, Tiago Taveira, Ricardo Leitão, Pedro B. Ribeiro, João Teixeira, Miguel Bastos, Isabel Moital, Arune Bhuralal, Isabel Oliveira, Ana Teresa Mota, Luís Costa, Francisco Fonseca, João Nelas, Tiago Queiroz, António Padilha, Rita Mateus, Daniel Correia, João Saro João Pereira Amorim, Sérgio Nunes, Telmo Gomes, André Morais, Antonio Loureiro, Beatriz Bagulho, Tiago Stock, Joaquim Manuel Jorge Borges, Gabriel Candal, Joaquim Ribeiro, Fábio Monteiro, João Barbosa, Tiago M Machado, Rita Sousa Pereira, Henrique Pedro, Cloé Leal de Magalhães, Francisco Moura, Rui Antunes7, Joel, Pedro L, João Diamantino, Nuno Lages, João Farinha, Henrique Vieira, André Abrantes, Hélder Moreira, José Losa, João Ferreira, Rui Vilao, Jorge Amorim, João Pereira, Goncalo Murteira Machado Monteiro, Luis Miguel da Silva Barbosa, Bruno Lamas, Carlos Silveira, Maria Francisca Couto, Alexandre Freitas, Afonso Martins, José Proença, Jose Pedroso, Telmo , Francisco Vasconcelos, Duarte , Luis Marques, Joana Margarida Alves Martins, Tiago Parente, Ana Moreira, António Queimadela, David Gil, Daniel Pais, Miguel Jacinto, Luís Santos, Bernardo Pimentel, Gonçalo de Paiva e Pona , Tiago Pedroso, Gonçalo Castro, Inês Inocêncio, Hugo Ramos, Pedro Bravo, António Mendes Silva, paulo matos, Luís Brandão, Tomás Saraiva, Ana Vitória Soares, Mestre88 , Nuno Malvar, Ana Rita Laureano, Manuel Botelho da Silva, Pedro Brito, Wedge, Bruno Amorim Inácio, Manuel Martins, Ana Sousa Amorim, Robertt, Miguel Palhas, Maria Oliveira, Cheila Bhuralal, Filipe Melo, Gil Batista Marinho, Cesar Correia, Salomé Afonso, Diogo Silva, Patrícia Esquível , Inês Patrão, Daniel Almeida, Paulo Ferreira, Macaco Quitado, Pedro Correia, Francisco Santos, Antonio Albuquerque, Renato Mendes, João Barbosa, Margarida Gonçalves, Andrea Grosso, João Pinho , João Crispim, Francisco Aguiar , João Diogo, João Diogo Silva, José Oliveira Pratas, João Moreira, Vasco Lima, Tomás Félix, Pedro Rebelo, Nuno Gonçalves, Pedro , Marta Baptista Coelho, Mariana Barosa, Francisco Arantes, João Raimundo, Mafalda Pratas, Tiago Pires, Luis Quelhas Valente, Vasco Sá Pinto, Jorge Soares, Pedro Miguel Pereira Vieira, Pedro F. Finisterra, Ricardo Santos _______________ Esta conversa foi editada por: Hugo Oliveira _______________ Bio: Luísa Lopes é neurocientista, coordenadora de um grupo de investigação no Instituto de Medicina Molecular e Professora Convidada na Faculdade de Medicina da Universidade de Lisboa. Estudou na Escola Secundária do Bombarral, licenciou-se em Bioquímica na Faculdade de Ciências de Lisboa e mais tarde doutorou-se em Neurociências na Faculdade de Medicina da mesma Universidade. Trabalhou em Cambridge, no Reino Unido, em Estocolmo, na Suécia e em Lausanne, Suiça, antes de regressar a Lisboa, onde a partir de 2008 estabeleceu a sua própria equipa de investigação, tendo em 2013 e 2018 obtido posições de Investigador da Fundação para Ciência e Tecnologia. O seu trabalho centra-se nos mecanismos que causam o envelhecimento precoce das funções associadas à memoria, e o desenvolvimento de modelos animais de envelhecimento para estudar o défice cognitivo e neurodegeneração. Tem múltiplos artigos e capítulos de livros publicados em revistas científicas internacionais, incluindo revistas de referência na área, tal como Nature Neuroscience, Science Immunology ou Molecular Psychiatry e doutorou 8 estudantes na sua equipa. Em 2010, Luísa recebeu um prémio da Dana Alliance for Brain pelas actividades de divulgação científica enquanto coordenadora das actividades da Semana do Cérebro em Lisboa. Pertence a várias sociedades científicas portuguesas e internacionais, destacando-se ter sido membro da Direcção da Sociedade Portuguesa de Neurociências entre 2008 e 2011. É membro Conselho Científico da Faculdade de Medicina e da equipa de cordenação do Mestrado em Investigação Biomédica. Em 2017 recebeu uma menção honrosa da Universidade de Lisboa pelo seu currículo científico na área de Biomedicina, em 2018 o Prémio Mantero Belard – Santa Casa da Misericórdia de Lisboa, em 2020 o prémio Pfizer em Investigação Biomédica, e em 2022 o Prémio Interstellar Initiative para “Healthy Aging and Longevity” da Academia de Ciências de Nova Iorque. Em 2021 recebeu o seu grau de Agregação na Faculdade de Medicina de Lisboa. 

In this episode Associate Professor Jeffrey Looi and his guests discuss topics including the recent pandemic and other related themes which was presented during the Presidential Symposium hosted at the 2022 RANZCP Congress in Sydney.Associate Professor Jeffrey Looi, MBBS Syd, MD ANU, DMedSc Melb, FRANZCP, AFRACMA, is a clinical academic neuropsychiatrist, in private and public practice, and Head of the Academic Unit of Psychiatry and Addiction Medicine at the Australian National University Medical School. Jeffrey leads the Australian, United States, Scandinavian-Spanish Imaging Exchange (AUSSIE) and the Consortium of Australian-Academic Psychiatrists for Independent Policy and Research Analysis (CAPIPRA). He has received multiple research and leadership awards including: a Fulbright Scholarship and Australian-Davos-Connection Future Summit Leadership Award. He is an co-author on more than 230 peer-reviewed papers, involving UCLA, Karolinska Institute and University of Melbourne.Professor Steve Kisely, Steve is a psychiatrist, addiction and public health physician.  He currently works as a Professor at the University of Queensland and Adjunct Professor in Psychiatry, Community Health and Epidemiology at Dalhousie University in Canada. He is also Director of Research for Addiction & Mental Health Services, Metro South Health. Steve is the author of over 380 peer-reviewed full-length papers, on physical/psychiatric co-morbidity, psychiatric epidemiology, pharmaco-epidemiology & health services research. He has been a principal investigator on grants worth $20.3 million. Steve does not hesitate in using research evidence to challenge accepted dogma and practice. Professor Tarun Bastiampillai, MBBS Adl, BMEDSc Adl, FRANZCP is a consultant psychiatrist and Clinical Professor at both Monash and Flinders University. Tarun is also a member of the Consortium of Australian-Academic Psychiatrists for Independent Policy and Research Analysis (CAPIPRA). He has served in several senior leadership roles, having been appointed SA Department of Health, Executive Director of Mental Health Strategy between 2015 to 2018. He is the recipient of the RANZCP 2020 Margaret Tobin Award for outstanding achievement in administrative psychiatry. He has published his research extensively including within, high-impact journals - JAMA, Lancet and Molecular Psychiatry.Feedback:If you have a topic suggestion or would like to participate in a future episode of Psych Matters, we'd love to hear from you.Please contact us by email at: psychmatters.feedback@ranzcp.orgDisclaimer:This podcast is provided to you for information purposes only and to provide a broad public understanding of various mental health topics.  The podcast may represent the views of the author and not necessarily the views of The Royal Australian and New Zealand College of Psychiatrists ('RANZCP'). The podcast is not to be relied upon as medical advice, or as a substitute for medical advice, does not establish a doctor-patient relationship and should not be a substitute for individual clinical judgement.  By accessing The RANZCP's podcasts you also agree to the full terms and conditions of the RANZCP's Website. Expert mental health information and finding a psychiatrist in Australian or New Zealand is available on the RANZCP's Your Health In Mind Website.

It's our 200th episode—time to reflect on where we've been and where we're headed! My first thought is how grateful I am for the opportunity to share with you and our community. Your comments, emails, and dms mean everything to me. They let me know you resonate with Love & Life's mission: “Conversations grounded in psych research to help us thrive in love and life.” On Love & Life, we're all about the research–which is why we're so dismayed by the degeneration of science we've recently witnessed. In this episode, we discuss 3 cases of faulty science which have just come to light, starting with an umbrella study by Joanna Moncrieff and colleagues which finds no connection between depression and serotonin levels. Although many psychiatrists have doubted the “chemical imbalance” explanation of depression for years, pharmaceutical companies continue to promulgate this unsubstantiated theory because it has, obviously, greatly boosted sales of antidepressants. We examine two other instances of manipulated science including a shocking revelation that the last 16 years of Alzheimer's research has been based on falsified brain images. And, the third example surrounds the bizarre and utterly unscientific response to the COVID pandemic over the last 2 ½ years. We look to science to help us explore and uncover truth. When findings are misrepresented, it shakes our confidence, but it also reminds us we need to be discerning and savvy when consuming information—even information coming from sources we once believed we could trust. What does all this mean for Love & Life? Ultimately, it reinforces our commitment to pushing back against Big Pharma and its efforts to medicalize our every emotion! I'm so grateful for your support over these last 200 episodes. Thank you SO MUCH for being a part of the Love & Life family! https://www.bmj.com/content/378/bmj-2021-067606 https://www.commonsense.news/p/tgif-debunked-edition Moncrieff, J., Cooper, R., Stocmann, T., Amendola, S., Hengartner, M., & Horowitz, M. (2022). The serotonin theory of depression: A systematic umbrella review of the evidence. Molecular Psychiatry. Whitaker, R. (2015). Anatomy of an Epidemic. Dr. Karin Website: http://loveandlifemedia.com/ Empowered Dating Playbook: smarturl.it/EmpoweredDatingBook Instagram: @dr.karin Single is the New Black: Audiobook Audible: smarturl.it/SITNB-Audible iTunes: smarturl.it/SITNB-iTunes --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/love-and-life-media/support

On July 20, 2022 a review was published in the journal of Molecular Psychiatry. This review compiled 30 years of research into serotonin and depression in full showing little evidence of any abnormality of serotonin in people with depression.The Chemical Imbalance theory of depression has been widely publicized by Doctors and the Media for decades. This serotonin theory of depression has influenced millions to take or continue antidepressant medication.IT IS REALLY IMPORTANT THAT YOU DO NOT STOP YOUR ANTIDEPRESSANTS SUDDENLY OR TOO FAST.Today we discuss this review and its implications. RADICALLY GENUINE PODCASTRadically Genuine Podcast Website Twitter: Roger K. McFillin, Psy.D., ABPPInstagram @radgenpodTikTok @radgenpodRadGenPodcast@gmail.comIf you are in a crisis or think you have an emergency, call your doctor or 911. If you're considering suicide, call 1-800-273-TALK to speak with a skilled trained counselor.ADDITIONAL RESOURCESMoncrieff, J., Cooper, R.E., Stockmann, T. et al. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry (2022)10:30 - Zoloft 2002 TV Ad Commercial19:00 - RollingStone: Who Is the Psychiatrist Behind the Antidepressant Study Taking Over Right-Wing Media?33:00 - The naturalistic course of unipolar major depression in the absence of somatic therapy36:00 - Relabeling the Medications We Call Antidepressants - PMC45:00 - How to take the news that depression has not been shown to be caused by a chemical imbalance | Joanna Moncrieff

People have been persuaded that depression is caused by a serotonin imbalance, but in this episode people may wish to reconsider whether taking antidepressants is the best thing for them.  According to a research study from the University College London at North East London NHS Trust,  “Thousands of people suffer from side-effects of antidepressants, including the severe withdrawal effects that can occur when people try to stop them, yet prescription rates continue to rise. We believe this situation has been driven partly by the false belief that depression is due to a chemical imbalance. It is high time to inform the public that this belief is not grounded in science. “ By Joanna Moncrieff professor of Psychiatry.The review, published in the journal of Molecular Psychiatry. This study involved tens of thousands of people examining their serotonin and depression and it's  breakdown products in their brain.This study explains that people should not necessarily be told that the reason they have depression is because of low levels of Serotonin, and leading them to believe that antidepressants is the solution. This is misinformation. This episode is based on studies proven by credible information. I do not recommend anyone to stop taking their antidepressants, but based on this review  I encourage everyone with concerns about their medication to contact  your Doctor.

Austin Perlmutter, M.D.: “Is inflammation involved in our poor mental health epidemic today? I believe the answer is yes.”  Austin, an integrative medicine doctor and New York Times bestselling author, joins mbg co-CEO, Jason Wachob, to discuss the complicated link between depression and serotonin, plus: - How to treat depression beyond medication (~13:01) - How to prevent depression before it becomes a problem (~14:32) - How social media and the news can contribute to inflammation (~16:57) - How to identify inflammatory relationships (~28:27) - Top foods for brain health (~30:05) Referenced in the episode: - Austin's book, Brain Wash. - Visit Big Bold Health. - Study in Molecular Psychiatry on the role of serotonin in depression. - mbg article discussing this study. - Austin's Instagram video discussing the serotonin study. - A study on the Mediterranean diet and depression. - Shop Himalayan tartary buckwheat. Jason's homemade Perfect bar recipe: - 1 ½ cup Santa Cruz Organic Light, Crunchy Peanut Butter - ¼ cup Big Bold Health Himalayan tartary buckwheat - ¼ cup Sunfood Superfoods Raw Organic Milled Flaxseed - 2 tbsp Lakanto Monkfruit - 1 tbsp Wholesome Raw & Unfiltered Organic White Honey - 1 handful (or whatever feels good) of Hu Chocolate Gems. - Mix nut butter, flours, honey, and monkfruit in bowl. - Lay out batter in a glass pan over parchment paper, and even out with a roller. - Drop in as many gems as you like. - Put in freezer for 90 minutes, then put in the fridge and slice up into squares.  We hope you enjoy this episode sponsored by Sonos, and feel free to watch the full video on Youtube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com.

Our guest today, psychiatrist Dr. Joanna Moncrieff, has created quite a buzz with her recent journal article that capsized the brain chemistry imbalance hypothesis of depression. The article is scientifically sound and well respected by her peers; however, it is a threat to the big pharma industry and other narratives regarding the individual defect theory of mental health. Marx, Spinoza, and the Political Implications of Contemporary Psychiatry | CounterPunch by Bruce Levine | June 7, 2022 The Political Economy of the Mental Health System: A Marxist Analysis | Frontiers in Sociology by Joanna Moncrieff | Jan 17, 2022 The serotonin theory of depression: a systematic umbrella review of the evidence | Molecular Psychiatry by Joanna Moncrieff | June 21, 2022 #JoannaMoncrieff #UniversityCollegeLondon #seritonin #depressioin #mentalhealth #molecularpsychiatry #politicaleconomy #Frontierssociology #brainchemisrty #bigpharma #counterpunch #greggodels #zzblog #zzsblog #patcummings #ComingFromLeftField #podcast 

New research suggests that alcohol directly accelerates the aging process. In the study, published in the journal Molecular Psychiatry, scientists from Oxford Population Health examined the link between alcohol consumption and telomere length in almost 250,000 adults. Telomeres are DNA sequences that cap the end of chromosomes, protecting them from damage. Telomere length is considered […] The post 241. Alcohol directly accelerates aging appeared first on Dr. David Geier - Feel and Perform Better Than Ever.

W najnowszej odsłonie „Skądinąd” gości dr n. med. Cezary Żechowski, psychiatra i psychoterapeuta. A rozmawiamy o źródłach depresji. Rozmawiamy także o metaanalizie opublikowanej niedawno na łamach „Molecular Psychiatry”, z których wynika, że serotoninowa teoria depresji nie ma oparcia w faktach. O skuteczności leków przeciwdepresyjnych. O historii psychiatrii. O najnowszej wiedzy dotyczącej źródeł psychologicznego cierpienia. O nowych nurtach w farmakologii i psychoterapii. A także o wielu jeszcze innych sprawach. Owocnego słuchania!

Neste episódio do E Tem Mais, Carol Nogueira apresenta um panorama das descobertas da ciência na busca por uma melhor compreensão dos fatores que contribuem para o desenvolvimento da depressão e o tratamento da doença. Um grupo de cientistas europeus publicou um novo estudo na revista especializada Molecular Psychiatry que aponta não existirem evidências suficientes de uma associação direta entre a depressão e baixos níveis de serotonina no cérebro. A pesquisa reabre o leque de diferentes abordagens para lidar com a doença, além dos remédios já adotados. Um levantamento recente da OMS revelou que casos de ansiedade e depressão cresceram 25% no primeiro ano da pandemia de Covid-19. No Brasil, dados do Ministério da Saúde apontaram que mais de um em cada dez brasileiros relataram ter recebido um diagnóstico médico da doença. Para descrever quais as orientações e as dúvidas que ainda cercam o combate à depressão, participam deste episódio os psiquiatras Helian Nunes de Oliveira, professor da Universidade Federal de Minas Gerais (UFMG), e Marcelo Feijó, da Escola Paulista de Medicina. Com apresentação de Carol Nogueira, este podcast é produzido pela Maremoto para a CNN Brasil. Você também pode ouvir o E Tem Mais no site da CNN Brasil. E aproveite para conhecer os nossos outros programas em áudio. Acesse: cnnbrasil.com.br/podcasts.

第41期脑科学新闻 | 孤独的果蝇睡得少吃得多，年轻鼠的脑脊液改善老年鼠的记忆能力导读：海德，陶火，Li Xun责编：呆苏克主播：小胡背景音乐：夜的钢琴曲五_石进Nature | 孤独的果蝇，睡眠更少，吃得更多自新冠疫情爆发以来，“隔离”就成了我们生活中“常客”。与隔离一同出现的，除了焦躁不安的情绪、人际关系的疏离，往往还有与日俱增的体重和日益减少的睡眠。事实上，这种现象不仅仅出现在人类身上，小小的果蝇也是如此。近日，来自洛克菲勒大学的研究人员使用定量行为分析和生物信息学分析来研究了果蝇在短期或长期社会隔离后大脑状态的差异，发现短期社会隔离（与群体分隔1天或3天）并不会导致果蝇睡眠不足，而长期社会隔离（与群体分隔5天或7天）则会显著降低果蝇睡眠时间。此外，缺乏社交活动的果蝇大脑状态与其饥饿时非常相似，表明长期社会隔离可能会改变代谢相关基因的表达，从而引发“饥饿”。研究人员在进一步研究中发现P2神经元对该效应有重要作用。沉默果蝇的P2神经元可显著降低长期社会隔离对果蝇的影响，而激活短期社会隔离组果蝇的P2神经元则会导致睡眠不足和更多的食物摄入。这些结果表明，P2神经元参与了调节社会隔离效应的回路，并可能发挥类似“计时器”的作用，监测隔离持续的时长。这一研究揭示了果蝇和人类在面对长期的“社会隔离”时具有许多相似之处，并建立起了一个可以用于研究社会隔离对大脑、心理的影响的模型，同时给予了我们更多利用低等生物来模拟和研究人类心理健康现象的灵感。（导读：海德）文章来源：https://www.nature.com/articles/s41586-021-03837-0图片来源：https://static01.nyt.com/images/2020/03/24/science/24BRODYISOLATION/24BRODYISOLATION-superJumbo.jpgNature | 年轻鼠的脑脊液改善老年鼠的记忆能力在缓慢老去的过程中，人的记忆力往往会越来越差，且目前尚无能够有效改善或提高记忆力的方法。在人均寿命日益延长的今天，减缓大脑衰老或设法保持大脑的认知、记忆功能成为了一个亟待解决的问题。近日，来自斯坦福大学的Tony Wyss-Coray团队尝试将年轻小鼠（10周龄）的脑脊液灌注进老年小鼠（18月龄）的脑中，发现这一举措可以显著改善老年小鼠在恐惧条件反射任务中的记忆表现。通过对海马体进行转录组分析，研究人员发现少突胶质细胞可能是介导这一变化的关键细胞类群，并在体外和体内分别证实了年轻的脑脊液能够促进少突胶质细胞祖细胞的增殖、分化。研究人员随后用SLAMseq技术对新生成的mRNA进行标记，发现了受年轻脑脊液影响最大的“头号种子”——血清反应因子。对脑脊液中潜在的血清反应因子激活剂进行筛选，研究人员进一步确定了灌注成纤维细胞生长因子17 (Fgf17)能够诱导老年小鼠的少突胶质细胞祖细胞增殖并巩固长期记忆，而阻断Fgf17则会损害年轻小鼠的认知功能。利用年轻个体的身体成分“逆转”衰老过程的研究由来已久，但其背后的机制始终难寻。这一研究揭示了年轻的脑脊液中发挥作用的关键因子——Fgf17，厘清了“返老还童”这一神奇生理过程背后的生物学机制，也为治疗方法和药物的研发提供了新的可能。此外，这篇文章还证明了通过脑脊液给药方式治疗痴呆的可行性，对当今人口老龄化问题愈发严重的人类社会大有裨益。（导读：海德）文章来源：https://www.nature.com/articles/s41586-022-04722-0.pdf?origin=ppub图片来源：https://posturepractice.com/wp-content/uploads/2015/11/aging-memory-declin.jpgMolecular Psychiatry｜调节抑郁样行为的新环路：从内嗅皮层到次级视觉皮层根据世卫组织最新报告，抑郁症已成为人类致残的首要原因，全球罹患抑郁症的人群超2.8亿。但抑郁障碍病因复杂，相关机制研究和治疗手段仍十分有限。由于抑郁症涉及多个脑区，其被视作一种“神经环路疾病”（circuitopathies）。今年四月，清华大学郭增才课题组在线发表在《分子神经病学》（Molecular Psychiatry）上的一篇文章首次揭示了一条从内嗅皮层到次级视觉皮层内侧区的神经环路在抑郁症中具有双向调节作用。研究发现，在具有抑郁样表型的慢性社会挫败应激（CSDS）小鼠模型上，其内嗅皮层Va亚层神经活性降低。通过化学遗传和光遗传学方法，研究组发现抑制Ent→V2M通路可以诱发健康小鼠和加重应激小鼠抑郁样表型，而激活该通路则可以快速缓解抑郁样表型。该通路的作用机制与驱动小鼠转向抗抑郁状态相关。这为临床抑郁症的治疗提供了潜在靶点，特别是非侵入性刺激治疗，如经颅磁刺激、经颅直流电刺激等。（导读：陶火）文章链接：https://www.nature.com/articles/s41380-022-01540-8图片链接：https://pixabay.com/vectors/mental-therapy-counseling-people-6841357/?downloadNature Neuroscience | 5-羟色胺与中脑多巴胺在厌食症的作用在以瘦为美的时代，很多人都想拥有纤细的身材。但有一类患者，却因“瘦”而饱受折磨。厌食症（anorexia, AN）患者身形极度嶙峋，由于长期不能正常进食，他们严重营养不足，并且饱受精神折磨，痛苦不堪。近日，发表在Nature Neuroscience上的一篇文章研究了厌食症相关的分子机制。研究人员发现高浓度的多巴胺会增高中缝背核（dorsal raphe nucleus, DRN）5-羟色胺能神经元的放电频率与静息膜电位，而低浓度的多巴胺则产生相反效果。此外，腹侧被盖区（ventral tegmental area, VTA）的多巴胺能神经元可以投射到DRN，并调节其中的5-羟色胺能神经元。在将ChR2光敏感通道蛋白注入VTA的多巴胺能神经元时，低频（2Hz）蓝光会抑制DRN中5-羟色胺能神经元并增加小鼠对于食物的摄入（此过程可以被多巴胺受体D2拮抗剂阻止），而高频（20Hz）蓝光会激活DRN中5-羟色胺能神经元并抑制小鼠对于食物的摄入（此过程可以被多巴胺受体D1拮抗剂阻止）。在活动型厌食症（activity-based anorexia, ABA）小鼠模型中，激活的多巴胺能神经元激活DRN的5-羟色胺能神经元，这一过程依赖于多巴胺受体D1而非多巴胺受体D2。本研究提出了厌食症可能的生理机制，可能会为未来的临床治疗提供依据。（导读：Li Xun）文章链接：https://www.nature.com/articles/s41593-022-01062-0图片链接：https://cn.bing.com/images/search?q=%e5%8e%8c%e9%a3%9f%e7%97%87&form=HDRSC2&first=1&tsc=ImageHoverTitleNature Neuroscience | 青春期抑制丘脑活动对成年期前额叶的影响神经系统在青春期时可塑性增强，此时，外界刺激可能会对神经系统造成长久的影响。此外，精神分裂症与人脑前额叶（PFC）功能异常相关。那么，青春期其他脑区的异常会影响到成年期PFC的功能吗？来自哥伦比亚大学的研究团队探索了这一问题，研究者发现，在小鼠青春期而非成年期抑制丘脑，成年后小鼠的与PFC相关的认知行为测试受到影响。并且，小鼠内侧前额叶皮层（mPFC）2，3层锥体细胞的突触前兴奋性输入的数量或功能下降，这种下降是由于投射到mPFC的丘脑神经元减少，而非丘脑本身神经元减少。研究者激活这些投射到mPFC区域的丘脑神经元后，发现小鼠与前额叶皮层相关的认知行为测试得到改善。在更深一步研究中，他们发现γ脑电波与β脑电波无法解释青春期丘脑抑制导致成年期行为学异常这一现象。随后，研究者将mPFC中每一个放电的神经元进行关联，发现在行为学测试时，存在一个关联高峰，而青春期丘脑抑制会减弱这个高峰，后续激活丘脑会使得这个高峰增强。这提示青春期时，其他脑区的改变会影响到大脑的前额叶皮层。（导读：Li Xun）文章链接：https://www.nature.com/articles/s41593-022-01072-y图片链接：https://www.piqsels.com/zh/public-domain-photo-zbqclNature | 阿尔茨海默症神经元中积累了更多体细胞突变神经元功能障碍和死亡是阿尔茨海默症（AD）的症状之一，然而引发这一具体事件的生物学机制仍不清晰。近日，来自波士顿的研究人员分析了来自AD患者和正常对照组的319个神经元的单细胞全基因组测序数据，以探究与AD相关的体细胞突变数量、突变位置和突变种类。结果显示，AD神经元中的体细胞突变数目显著增加，且与正常衰老过程中主要是与年龄有关的模式积累突变特征A突变增加不同，AD神经元中由不正常的“灾难性”事件引发的特征C突变显著增多。研究人员推测这些变化可能与核苷酸的氧化相关，并通过实验证实了AD神经元中核苷酸氧化损伤水平上升。此外，AD神经元中的突变具有转录链偏好性，提示转录相关的切除修复可能在产生突变的过程中发挥作用。本研究发现AD神经元中体细胞突变异常积累且氧化应激水平上升，为神经退行性病变和AD的发病机制提供了新的研究线索和潜在的治疗靶点。（导读：海德）原文链接：https://www.nature.com/articles/s41586-022-04640-1图片来源：https://www.google.com.hk/url?sa=i&url=https%3A%2F%2Fwww.genengnews.com%2Fnews%2Fmechanism-that-prevents-the-death-of-neurons-identified%2F&psig=AOvVaw0ldjqwYoqif9TKNyOm7OGe&ust=1653017303790000&source=images&cd=vfe&ved=0CAkQjRxqFwoTCOjEv7vP6vcCFQAAAAAdAAAAABAD

This is episode #21 of the podcast and it's Thursday, the 7th of July, 2022. My guest today is Dr. Matthias Michel, a philosopher working at the Center for Mind, Brain, and Consciousness at the New York University. Although most of his research focuses on the scientific study of consciousness, he is also interested in non-human / animal consciousness. Matthias has also worked in the domain of 'philosophy of measurement' as it applies to the measurement of mental properties, especially in psychiatric research (for instance, in the measurement of fear and anxiety).We started the show by defining consciousness — discussing the ways in which we can assess our own conscious experience. Since the subjective aspect of consciousness makes its scientific study very challenging, I asked Matthias to summarize for us the current assessment methods used in the field. One such method (the use of subjective reports), although somewhat controversial, proves to be particularly important in applications like mental disorders (specifically, fear and anxiety). Matthias believes that cognitive neuroscience research on consciousness could give us a deeper understanding of mental disorders and their treatments. The second part of the interview covered technology where we focused in particular on the questions ‘can AI systems be conscious? And, if yes, how?' Matthias kindly shares with us his field's perspective as well as his own opinion on the topic.Here is the show.Show Notes:- Defining consciousness; Is human experience always conscious?- Does being conscious presuppose being aware? (And what kind of awareness is needed here?)- What makes the scientific study of consciousness challenging?- Applications: mental disorders (like fear and anxiety): how can the scientific field of consciousness help?- Subjective reports in the assessment of conscious experience- Technology: Can AI be conscious? How?Note:Relevant papers:Michel, Matthias. "The Mismeasure of Consciousness: A problem of coordination for the Perceptual Awareness Scale." Philosophy of Science 86.5 (2019): 1239-1249.Taschereau-Dumouchel, Vincent, et al. "Putting the “mental” back in “mental disorders”: a perspective from research on fear and anxiety." Molecular Psychiatry 27.3 (2022): 1322-1330.Lau, Hakwan. In Consciousness we Trust: The Cognitive Neuroscience of Subjective Experience. Oxford University Press. 2022. Link to Dr. Michel's website: https://matthias-michel.wixsite.com/michel

This week I am pleased to welcome Dr. William Courtney back to the program along with his wife Kristen Courtney for a second part to their interview. Dr. Courtney's area of special interest is in the dietary uses of cannabis to which he considers as a conditionally essential nutrient in the diet of individuals of 40 years and older, and Kristen brings a decade of personal experience and research to the area of whole plant use for prevention and treatment.In research, Dr. Courtney has presented on high dose non-psychoactive dietary uses at Cannabis Therapeutics in Rhode Island (April 2010), the Institute of Molecular Psychiatry at the University of Bonn (June 2010), the Institute for Advanced Studies at The Hebrew University of Jerusalem (November 2010), and the International Cannabinoid Research Society conference in Chicago (July 2011). Kristen has presented her case study and research to the International Cannabinoid Research Society (ICRS), the International Cannabis As Medicine Society, in Bonn, Germany (on the Endocannabinoid System), in Israel at the Institute for Advanced Studies and the Israel Science Foundation, and at the International Cannabis As Medicine conference in Germany. She is heading up the experimental research design department in Ettelbruck, Luxembourg, working with the Association Luxembourgeoise des Methodes Preventives. Kristen is also reporting for Shaughnessy: The Journal of Cannabis In Clinical Practice.From personal experience stems Kristen's healing story is a powerful motivator. She has used fresh cannabis leaf to put her Systemic Lupus, Rheumatoid Arthritis, Endometriosis, and numerous other conditions into a sustained remission. With 14 surgeries and 4 years of bed rest she has empathy as well as knowledge that has arisen from her education in statistics and research design, which helps her bridge the gap between patients, physicians, and researchers.Dr. Courtney and Kristen co-founded Cannabis International, which is working to reverse the United Nation's Convention One Treaty in order to allow people access to cannabis worldwide, and currently reside in the Commonwealth of Dominica, where they run the Nature Isle Sanctuary- offering consultations with individuals suffering from Endogenous Cannabinoid System deficiencies. Want to learn more about what they do? Check out their video on juicing raw cannabis.

This podcast is a discussion of the performance of the Victorian health system during the first year of the COVID-19 pandemic, with reference to the Australian and International context for health systems and population mental health. Issues related to managing through adversity, adaptation health, wellbeing, workforce and mental health service data collection are also discussed by Professors Vinay Lakra, Tarun Bastiampillai and Jeffrey Looi.There is forthcoming Australasian Psychiatry paper led by Professor Stephen Allison, together with the podcast presenters and Professor David Copolov that covers the background.Associate Professor Jeffrey Looi, MBBS Syd, MD ANU, DMedSc Melb, FRANZCP, AFRACMA, is a clinical academic neuropsychiatrist, in private and public practice, and Head of the Academic Unit of Psychiatry and Addiction Medicine at the Australian National University Medical School. Jeffrey leads the Australian, United States, Scandinavian-Spanish Imaging Exchange (AUSSIE) and the Consortium of Australian-Academic Psychiatrists for Independent Policy and Research Analysis (CAPIPRA). He has received multiple research and leadership awards including: a Fulbright Scholarship and Australian-Davos-Connection Future Summit Leadership Award. He is an co-author on more than 230 peer-reviewed papers, involving UCLA, Karolinska Institute and University of Melbourne.Associate Professor Vinay LakraAssociate Professor Vinay Lakra is the President of the College. He is also a Clinical Director and a member of the Victorian Board of Medical Board of Australia. He completed his medical and psychiatry training in India. He has had extensive involvement in supporting, training and mentoring SIMGs besides developing the assessment standards for SMIGs.Professor Tarun Bastiampillai, MBBS Adl, BMEDSc Adl, FRANZCP is a consultant psychiatrist and Clinical Professor at both Monash and Flinders University. Tarun is also a member of the Consortium of Australian-Academic Psychiatrists for Independent Policy and Research Analysis (CAPIPRA). He has served in several senior leadership roles, having been appointed SA Department of Health, Executive Director of Mental Health Strategy between 2015 to 2018. He is the recipient of the RANZCP 2020 Margaret Tobin Award for outstanding achievement in administrative psychiatry. He has published his research extensively including within, high-impact journals - JAMA, Lancet and Molecular Psychiatry.Feedback:If you have a topic suggestion or would like to participate in a future episode of Psych Matters, we'd love to hear from you.Please contact us by email at: psychmatters.feedback@ranzcp.orgDisclaimer:This podcast is provided to you for information purposes only and to provide a broad public understanding of various mental health topics.  The podcast may represent the views of the author and not necessarily the views of The Royal Australian and New Zealand College of Psychiatrists ('RANZCP'). The podcast is not to be relied upon as medical advice, or as a substitute for medical advice, does not establish a doctor-patient relationship and should not be a substitute for individual clinical judgement.  By accessing The RANZCP's podcasts you also agree to the full terms and conditions of the RANZCP's Website. Expert mental health information and finding a psychiatrist in Australian or New Zealand is available on the RANZCP's Your Health In Mind Website.

This week I am pleased to welcome Dr. William Courtney to the program, joining us from the middle of the rainforest, nonetheless. With an extensive medical education and having been immersed in the experiences of thousands of patients who use raw cannabis daily, Dr. Courtney's area of special interest is in the dietary uses of cannabis- which he considers a conditionally essential nutrient in the diet of individuals. Dr. William Courtney began with a Bachelor of Science in Microbiology from the University of Michigan, he received his Doctor of Medicine from Wayne State University, Interned for Residency in Psychiatry at California Pacific Medical Center, and then went on to earn his Post Doctorate in Forensic Examination and Forensic Medicine. Now, he is a member of the American Academy of Cannabinoid Medicine, the International Cannabinoid Research Society, the International Association of Cannabis as Medicine, and the Society of Clinical Cannabis. Dr. Courtney has also been teaching Continuing Medical Education (CME) courses in clinical cannabis.One of the world's foremost pioneers in cannabis research, Dr. Courtney seeks to consolidate the science regarding the essential nature of the phytocannabinoid contributions to health maintenance and restoration. Some notable achievements in his career are he has presented on high dose non-psychoactive dietary uses at Cannabis Therapeutics in Rhode Island in April 2010, the Institute of Molecular Psychiatry at the University of Bonn in June 2010, the Institute for Advanced Studies at The Hebrew University of Jerusalem in November 2010, the International Cannabinoid Research Society conference in Chicago in July 2011, and is the father of AC/DC (Alternative Cannabinoid Dietary Cannabis), a high CBD content cultivar from Cannatonic seeds acquired during a visit to Barcelona, Spain from Resin Seeds. Dr. Courtney owns Cannabis International and currently resides in the Commonwealth of Dominica, where he runs the Nature Isle Sanctuary- offering consultations with individuals suffering from Endogenous Cannabinoid System deficiencies. His work now primarily focuses on consultations and strain development/ advice.

Come join Christian and Mike as they discuss how birth, feeding and environmental factors affect the gut, brain and neurodevelopment through the lens of the microbiome. Pika pika. References for those playing at home: 1. Kerns CM, Winder-Patel B, Iosif AM, et al. Clinically Significant Anxiety in Children with Autism Spectrum Disorder and Varied Intellectual Functioning. J Clin Child Adolesc Psychol. 2021;50(6):780-795. 2. Neurodevelopmental Disorders. Diagnostic and Statistical Manual of Mental Disorders. Published online May 22, 2013. 3. Restrepo B, Angkustsiri K, Taylor SL, et al. Developmental–behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms. Autism Research. 2020;13(10):1778-1789. 4. Wexler HM. Bacteroides: the Good, the Bad, and the Nitty-Gritty. Clinical Microbiology Reviews. 2007;20(4):593. 5. Ho LKH, Tong VJW, Syn N, et al. Gut microbiota changes in children with autism spectrum disorder: A systematic review. Gut Pathogens. 2020;12(1):1-18. 6. Vaiserman A, Romanenko M, Piven L, et al. Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population. BMC Microbiology. 2020;20(1):1-8. 7. Stojanov S, Berlec A, Štrukelj B. The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease. Microorganisms 2020, Vol 8, Page 1715. 2020;8(11):1715. 8. Rizzardi KF, Indiani CM dos SP, Mattos-Graner R de O, de Sousa ET, Nobre-dos-Santos M, Parisotto TM. Firmicutes Levels in the Mouth Reflect the Gut Condition With Respect to Obesity and Early Childhood Caries. Frontiers in Cellular and Infection Microbiology. 2021;11:472. 9. Magne F, Gotteland M, Gauthier L, et al. The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients? Nutrients. 2020;12(5). 10. Korpela K. Impact of Delivery Mode on Infant Gut Microbiota. Ann Nutr Metab. 2021;77:11-19. 11. Niu J, Xu L, Qian Y, et al. Evolution of the Gut Microbiome in Early Childhood: A Cross-Sectional Study of Chinese Children. Frontiers in Microbiology. 2020;11:439. 12. Lin CW, Septyaningtrias DE, Chao HW, et al. A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model. Molecular Psychiatry 2022. Published online May 2, 2022:1-12. 13. Liu F, Li J, Wu F, Zheng H, Peng Q, Zhou H. Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review. Translational Psychiatry 2019 9:1. 2019;9(1):1-13. 14. de Angelis M, Francavilla R, Piccolo M, de Giacomo A, Gobbetti M. Autism spectrum disorders and intestinal microbiota. https://doi.org/101080/1949097620151035855. 2015;6(3):207-213. 15. Wang M, Li M, Wu S, et al. Fecal Microbiota Composition of Breast-fed Infants is Correlated with Human Milk Oligosaccharides Consumed. J Pediatr Gastroenterol Nutr. 2015;60(6):825. 16. Martin R, Makino H, Yavuz AC, et al. Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota. PLoS One. 2016;11(6). 17. Rutayisire E, Huang K, Liu Y, Tao F. The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: A systematic review. BMC Gastroenterology. 2016;16(1).

Soutenir et s'abonner à NeurosapiensDans cet épisode, nous allons aborder ensemble le sujet de l'intelligence et plus spécifiquement du haut potentiel intellectuel.Cet épisode sera découpé en 3 grands thèmes. Pour commencer, on se fera un petit mémo sur l'intelligence. Ce qu'elle est, ce qu'elle n'est pas. Ce qu'on sait sur l'intelligence aujourd'hui en neurosciences. Ensuite, nous ferons un focus sur le haut potentiel actuel où nous décortiquerons les mythes et les réalités.L'Instagram de Confidences de Psy :https://www.instagram.com/confidencesdepsy/Production, animation, réalisation et illustration : Anaïs RouxInstagram : https://www.instagram.com/neurosapiens.podcast/neurosapiens.podcast@gmail.comMusique d'intro KEEP ON GOINGMusique proposée par La Musique LibreJoakim Karud - Keep On Going : https://youtu.be/lOfg0jRqaA8Joakim Karud : https://soundcloud.com/joakimkarudSOURCESG. E. Gignac et al., Brain volume and intelligence : The moderating role of intelligence measurement quality, Intelligence, vol. 64, pp. 18-29, 2017.K. H. Lee et al., Neural correlates of superior intelligence : Stronger recruitment of posterior parietal cortex, Neuroimage, vol. 29, pp. 578-586, 2006.S. Sniekers et al., Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence, Nature Genetics, vol. 49, pp. 1107, 2017.D. Zabaneh et al., A genome-wide association study for extremely high intelligence, Molecular Psychiatry, vol. 23, pp. 1226-1232, 2018.F. Schmiedek et al., Within-person structures of daily cognitive performance cannot be inferred from between-person structures of cognitive abilities, PeerJ Preprints, vol. 7, 7:e27576v1, 2019. Voir Acast.com/privacy pour les informations sur la vie privée et l'opt-out. Become a member at https://plus.acast.com/s/neurosapiens.

In this episode, we discuss the science behind the widely accepted fact that we are all addicted to sugar. We talk about the original French study that involved rats who seemed to prefer sugar over cocaine causing an avalanche of headlines stating that sugar is more addicting than cocaine (Lenoir et al. 2007). We discussed the promising work of Dr. Anna Clara Bobadilla. We fully explore all the crap we find on the internet about this topic. Studies mentioned 2007 "Intense Sweetness Surpasses Cocaine Reward" PLoS One by Lenoir et al. 2016 “Food/Sugar addiction” published in the European Journal of Nutrition by Westwater et al. 2021 “Sugars and Sweet Taste: Addictive or Rewarding?” by Greenberg et al. 2020 "Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core" published in Molecular Psychiatry by Bobadila et al. Cat is drinking coffee in order to survive this week. Kelly is drinking Oat Milk hot chocolate

ADHD -  attention deficit hyperactivity disorder - is a condition characterized by differences in brain development and brain activity that affect attention, the ability to sit still, and impulse control. It affects millions of children and adults and has far-reaching effects on the lives and well-being of these individuals. And yet we still don't know what going on!Is it genetic? Is it environmental? Come and listen to learn a little bit more about the neuroscience of ADHD and what's going on in your head. Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Citations and relevant pictures below:Demontis D, Walters RK, Martin J, et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics. 2018;51(1):63-75. doi:10.1038/s41588-018-0269-7Faraone SV, Larsson H. Genetics of attention deficit hyperactivity disorder. Molecular Psychiatry. 2018;24(4). doi:10.1038/s41380-018-0070-0Froehlich TE, Anixt JS, Loe IM, Chirdkiatgumchai V, Kuan L, Gilman RC. Update on Environmental Risk Factors for Attention-Deficit/Hyperactivity Disorder. Current Psychiatry Reports. 2011;13(5):333-344. doi:10.1007/s11920-011-0221-3Oscar Berman M, Blum K, Chen TJ, et al. Attention-deficit-hyperactivity disorder and reward deficiency syndrome. Neuropsychiatric Disease and Treatment. 2008;4(5):893. doi:10.2147/ndt.s2627Quist JF, Barr CL, Schachar R, et al. The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. Molecular Psychiatry. 2003;8(1):98-102. doi:10.1038/sj.mp.4001244Zulauf CA, Sprich SE, Safren SA, Wilens TE. The Complicated Relationship Between Attention Deficit/Hyperactivity Disorder and Substance Use Disorders. Current Psychiatry Reports. 2014;16(3). doi:10.1007/s11920-013-0436-6Tomasi D, Volkow ND, Wang R, et al. Dopamine Transporters in Striatum Correlate with Deactivation in the Default Mode Network during Visuospatial Attention. Rustichini A, ed. PLoS ONE. 2009;4(6):e6102. doi:10.1371/journal.pone.0006102Ritalin Poses Cognitive Risks to Those Without ADHD. Pharmacy Times. https://www.pharmacytimes.com/view/ritalin-poses-cognitive-risks-to-those-without-adhdSupport the show (https://www.patreon.com/neuroscienceamateurhour)

Chronic respiratory disorders like asthma affect around 600 million people worldwide. although these illnesses are widespread, they can have several different underlying causes, making them difficult to treat. On this episode we chat with William Reay a researcher from the University of Newcastle, School of Biomedical Sciences and Pharmacy, whose work focuses on integrating statistical genetics with systems biology to further our knowledge of the biological processes involved in complex disorders and how this could be leveraged for treatment in the future. William is particularly passionate about the application of this approach to psychiatry, as novel interventions remain urgently required to improve patient outcomes.  His research has thus far been published in prestigious journals including Molecular Psychiatry and Brain, Behaviour, and Immunity and presented at conferences including the World Congress of Psychiatric Genetics and Schizophrenia International Research Society. Follow William's interesting work on Twitter @williamreay96 --- Send in a voice message: https://anchor.fm/suren-ladd/message

This episode of Psych Matters discusses research conducted by the Consortium of Australian-Academic Psychiatrists for Independent Policy Research and Analysis (CAPIPRA), focused on improve mental healthcare delivery for patients and the community. The research addresses responses to various commissions and inquiries related to mental healthcare, as well as analysis of population datasets on mental healthcare. Professors Jeffrey Looi and Tarun Bastiampillai present their collaborative research.Associate Professor Jeffrey Looi, MBBS Syd, MD ANU, DMedSc Melb, FRANZCP, AFRACMA, is a clinical academic neuropsychiatrist, in private and public practice, and Head of the Academic Unit of Psychiatry and Addiction Medicine at the Australian National University Medical School. Jeffrey leads the Australian, United States, Scandinavian-Spanish Imaging Exchange (AUSSIE) and the Consortium of Australian-Academic Psychiatrists for Independent Policy and Research Analysis (CAPIPRA). He has received multiple research and leadership awards including: a Fulbright Scholarship and Australian-Davos-Connection Future Summit Leadership Award. He is an co-author on more than 195 peer-reviewed papers, including research at the UCLA Medical School, Karolinska Institute and University of Melbourne.Professor Tarun Bastiampillai, MBBS Adl, BMEDSc Adl, FRANZCP is a consultant psychiatrist and Clinical Professor at both Monash and Flinders University. Tarun is also a member of the Consortium of Australian-Academic Psychiatrists for Independent Policy and Research Analysis (CAPIPRA). He has served in several senior leadership roles, having been appointed SA Department of Health, Executive Director of Mental Health Strategy between 2015 to 2018. He is the recipient of the RANZCP 2020 Margaret Tobin Award for outstanding achievement in administrative psychiatry. He has published his research extensively including within, high-impact journals - JAMA, Lancet and Molecular Psychiatry.SAGE JournalsMembers login to RANZCP.org and access journals. Search for these titles on the Journals website: The productivity commission report on mental health: Recommendations with negative consequences for clinical care in public and private sectorsTertiary eating disorder services: is it time to integrate specialty care across the life span?National mental health policy and Australia's ‘Deaths of despair'Other papers:Headspace, an Australian Youth Mental Health Network:Lessons for Canadian Mental HealthcareThe COVID-19 pandemic and epidemiologic insights from recession-related suicide mortalityWhen should governments increase the supply of psychiatric beds?Disclaimer: This podcast is provided to you for information purposes only and to provide a broad public understanding of various mental health topics.  The podcast may represent the views of the author and not necessarily the views of The Royal Australian and New Zealand College of Psychiatrists ('RANZCP'). The podcast is not to be relied upon as medical advice, or as a substitute for medical advice, does not establish a doctor-patient relationship and should not be a substitute for individual clinical judgement.  By accessing The RANZCP's podcasts you also agree to the full terms and conditions of the RANZCP's Website. Expert mental health information and finding a psychiatrist in Australian or New Zealand is available on the RANZCP's Your Health In Mind Website.

Title: This week the Kaleidoscope team are talking about the unsung hero that is statistics, the maths that influences what we deem important in research, and an exciting emerging idea in schizophrenia. Citations: Gelman, A., & Vehtari, A. (2020). What are the most important statistical ideas of the past 50 years?. arXiv preprint arXiv:2012.00174 Mealer RG, Williams SE, Daly MJ et al. Glycobiology and schizophrenia: a biological hypothesis emerging from genomic research. Molecular Psychiatry, 2020; 25:3129-3139.

Gary takes on the real issues that the mainstream media is afraid to tackle. Tune in to find out the latest about health news, healing, politics, and the economy.    L-theanine improves neurophysiologic measures of attention in dose-dependent manner University of Peradeniya (Sri Lanka), February 22, 2021 According to news reporting originating from Peradeniya, Sri Lanka,research stated, “L-theanine, a non-proteinic amino acid found in tea, is known to enhance attention particularly in high doses, with no reported adverse effects. We aimed to determine whether oral administration of L-theanine acutely enhances neurophysiological measures of selective attention in a dose-dependent manner.” Our news editors obtained a quote from the research from the University of Peradeniya, “In a double-blind, placebo-controlled, counterbalanced, 4-way crossover study in a group of 27 healthy young adults, we compared the effects of 3 doses of L-theanine (100, 200 and 400 mg) with a placebo (distilled water) on latencies of amplitudes of attentive and pre-attentive cognitive event-related potentials (ERPs) recorded in an auditory stimulus discrimination task, before and 50 min after dosing. Compared to the placebo, 400 mg of theanine showed a significant reduction in the latency of the parietal P3b ERP component (p < 0.05), whereas no significant changes were observed with lower doses. A subsequent exploratory regression showed that each 100-mg increase in dose reduces the P3b latency by 4 ms (p < 0.05). No dose-response effect was observed in P3b amplitude, pre-attentive ERP components or reaction time. The findings indicate L-theanine can increase attentional processing of auditory information in a dose-dependent manner.” According to the news editors, the research concluded: “The linear dose-response attentional effects we observed warrant further studies with higher doses of L-theanine.” This research has been peer-reviewed.   Lost your appetite? Nutmeg oil can bring it back Kyoto University (Japan), February 21 2021 Loss of appetite is treated by directly addressing its cause. However, depending on the condition it’s associated with, treatment can be expensive. But in a recent study, researchers at Kyoto University investigated a potential treatment for loss of appetite that’s both inexpensive and easy to administer. Myristica fragrans, from which this natural medicine is derived, is an evergreen tree native to the Moluccas, or Spice Islands, of Indonesia. The seeds of this exotic plant are the main source of two popular culinary spices, namely, nutmeg and mace. According to previous studies, the oil derived from the fruits and seeds of the nutmeg tree has appetite-enhancing properties. Nutmeg oil is also traditionally used to treat digestive issues, such as bloating, gastrointestinal distress and decreased appetite. The researchers explored the beneficial properties and active components of nutmeg oil in an article published in the Journal of Natural Medicines. Nutmeg oil shows appetite-enhancing effects in vivo The spice known as nutmeg is popular for its warm, nutty flavor that goes well with sweet and savory dishes. It is widely used today in the culinary world and can be found in almost every kitchen around the world. In Asian countries, nutmeg is not only used as an ingredient, but it also has a long history of use as herbal medicine that can improve a person’s appetite. (Related: Nutmeg exhibits powerful anti-diabetes properties, concludes study.) According to previous studies, nutmeg oil contains two active phytochemicals, myristicin and methyl eugenol. Myristicin is also present in parsley, black pepper, carrots and dill, and is said to have anti-inflammatory, antibacterial, antioxidant, anti-proliferative, anti-cholinergic and hepatoprotective properties. Methyl eugenol, meanwhile, is a compound present in various essential oils. It has been reported to have antibacterial, antifungal, insecticidal, anesthetic and antioxidant properties. In one animal study, researchers found that inhalation of myristicin and methyl eugenol increased the appetite mice. Because of this, the two compounds have attracted the attention of healthcare professionals who care for older people with dementia. Loss of appetite is not unusual for these patients since they tend to suffer from hypophagia, or a reduction in food intake and feeding behavior. Hypophagia, if left unaddressed, leads to frailty, and patients end up bedridden. Hence, inexpensive appetite-enhancing agents that are easy to administer are particularly desirable. In their study, the Japanese researchers found that inhalation of nutmeg oil, myristicin and methyl eugenol produced appetite-enhancing effects in mice. However, only methyl eugenol exerted both appetite-enhancing and locomotor-reducing effects at the same dose. According to a previous study, benzylacetone, an attractant compound found abundantly in flowers, also exerted the same effects at the same dose, and even increased the bodyweight of mice significantly. Methyl eugenol, however, did not have the same effect on body weight because the mice experienced olfactory habituation — reduced behavioral response due to repeated exposure — after several inhalations. The researchers believe that their study provides crucial information for identifying suitable compounds that can be used for the long-term treatment of appetite loss.   Case Study Shows Cannabis Led To Remarkable Improvement In Childhood Autism Symptoms Caleo Health Clinic (Canada) and Alberta Children's Hospital, February 21, 2021 An extremely promising case study was recently published in the Journal of Medical Case Reports illustrating the positive effects of cannabis extract and its association with improved autism related behavioral symptoms. According to the authors, “the pharmacological treatment for autism spectrum disorders is often poorly tolerated and has traditionally targeted associated conditions, with limited benefit for the core social deficits. We describe the novel use of a cannabidiol-based extract that incidentally improved core social deficits and overall functioning in a patient with autism spectrum disorder, at a lower dose than has been previously reported in autism spectrum disorder.” The case study focused on a child with autism who was switching out prescription seizure medicine for his epilepsy with a very low cannabidiol-based extract dose. The study found that not only did the cannabidiol extract help with his seizures, but he also “experienced unanticipated positive effects on behavioral symptoms and core social deficits,” according to the study. Researchers pointed out that to modify disruptive behaviors and improve social communication skills, often times children with autism are prescribed psychopharmacologic medications that target specific ASD core behaviors (for example, repetitive behaviors) and associated behaviors (for example, hyperactivity, aggression, anxiety, and sleep disturbances), but do not treat core social communication deficits. They explain that these medications are known for producing “substantial side effects.” For example, aripiprazole and risperidone, the only two medications approved by the US Food and Drug Administration (FDA) to treat irritability and agitation in ASD, frequently cause somnolence, increased appetite, and weight gain. These factors have led to families seeking alternative treatments outside of the psychopharmacologic realm. One of the newest forms of these alternative medicines is cannabidiol-based extract. Researchers reported that the patient’s symptoms improved within six-months of treatment, and that he has maintained “positive effects on his behavioral symptoms, anxiety, sleep, and social deficits” since that time. The results of CBE treatments, according to the case study, were nothing short of remarkable. He became more motivated and energetic, starting his own vegetarian diet and exercise programs, ultimately losing 6.4 kg after starting CBE for a calculated BMI of 21.33 kg/m2. He was able to start his first part-time job helping customers and interacting with them. He was instructed to fill out the self-administered Adult AQ which resulted in a normal score of 10. His mother stated he now also has a girlfriend. “This case report provides evidence that a lower than previously reported dose of a phytocannabinoid in the form of a cannabidiol-based extract may be capable of aiding in autism spectrum disorder-related behavioral symptoms, core social communication abilities, and comorbid anxiety, sleep difficulties, and weight control,” authors concluded. “Further research is needed to elucidate the clinical role and underlying biological mechanisms of action of cannabidiol-based extract in patients with autism spectrum disorder.” According to a report in Norml, these finding back up previous research published last year by investigators at Tufts University in Boston who similarly reported that the oral administration of cannabis-based products is associated with improvements in autistic symptoms in patients with self-injurious behaviors and co-morbid epilepsy, Several small clinical trials – such as those reported here, here, here, and here – have also previously reported that plant-derived cannabis extracts are effective and well-tolerated in mitigating various symptoms in patients with ASD, including hyperactivity, seizures, anxiety, and rage attacks.   High Homocysteine Levels May Increase Risk Of Heart Attack, Stroke, & Alzheimer’s Disease Temple University, February 14, 2021 There is a strong need for increased awareness, better prevention, detection, and treatment of Alzheimer’s disease with well over 5 million Americans currently suffering from this debilitating brain-wasting disease, and this number is projected to triple over the next few decades Research has found a link between Alzheimer’s disease and elevated levels of homocysteine. A recent study from Temple University has revealed another important connection between specific vitamin deficiencies and high homocysteine. Elevated homocysteine can increase the risk of dementia up to tenfold, and the list of ways this can affect the brain is long and damaging. This can include but is not limited to the formation of plaque in blood vessels that supply blood to the brain, development of chronic inflammation in the brain, and shrinkage of areas in the brain associated with memory. Additionally, excess homocysteine promotes the neurofibrillary tau tangles and harmful beta-amyloid plaques that are associated with AD, and it can interfere with the DNA repair process needed for brain cell maintenance. The harmful effects of elevated levels of homocysteine can all take a toll on brain function. For example, a study published in the Annals of Neuroscience found that elevated levels of homocysteine are associated with a 4.2-10.5 fold increased risk for vascular dementia, and the higher homocysteine rises the more damage it can cause. The study reported elevations in homocysteine were found to correspond closely to the degrees of cognitive impairment experienced by the participants. A report published in the Journal of Alzheimer’s Disease classified elevated homocysteine as a risk factor for Alzheimer’s disease, dementia, and cognitive decline. The researchers noted that the risk from elevated homocysteine was modifiable, meaning that reducing these levels could help to reduce the risk of brain damage. The recent study published in the journal Molecular Psychiatry describes the dangers of B-complex vitamin shortfalls in relation to homocysteine which is produced in the body in response to the breakdown of proteins and is normally detoxified by B-complex vitamins. Mice were deprived of vitamins B6, B9, and B12 for eight months, the animals were found to display elevated levels of homocysteine and 50% more tau tangles in the brain. The increased levels also caused increased levels of the pro-inflammatory chemical 5-LOX. The animals also displayed considerable difficulty with learning and remembering a water maze compared to the control group. The brain is not the only thing affected by high levels of homocysteine, this condition can also cause harm to the cardiovascular system including but not limited to damaging the lining of blood vessels, promoting deposits of plaque in the arteries that can cause a clog and increases the risk of heart attack or stroke. Research has shown that high levels of homocysteine is linked to a 42% increase in the risk of constricted carotid arteries which is a major risk factor for strokes. Elevated levels of homocysteine and poor arterial function can combine to interfere with the ability of the body to counter dangerous clotting inside of the arteries as well as with the ability of the heart to adapt to a blocked vessel by creating a new pathway. Elevated levels of homocysteine are dangerous to those with existing cardiovascular disease. A study involving over 3,000 participants with chronic heart disease found that elevated levels were associated with a 2.5 fold increased risk for coronary events. The researchers discovered a formula for measuring the risk, and suggested that every additional 5 micromoles per liter of homocysteine results in a 25% risk increase. As a product of less efficient detoxification functions levels of homocysteine tends to increase with aging. Genetics, stress, and the use of prescription drugs can also affect homocysteine levels. Experts suggest that a shortage in vitamins B2, B6, B9, and B12 that normally detoxify the amino acid are often the reason behind increasing levels of homocysteine. If you are concerned about your levels of homocysteine, or vitamin levels consult with your physician or certified medical professionals who may be able to address your concerns with a simple blood test. If you have reached or are approaching elderhood, with degenerative chronic conditions such as Alzheimer’s disease and heart disease on the rise it may be better to err on the side of caution and get checked rather than guess. Experts suggest that B complex vitamins are involved in breaking down homocysteine in the blood. These vitamins can be supplemented, but it is always best to obtain them via natural sources such as is found in eating a diet that is rich in fruits, vegetables, and whole grains. For example, vitamin B9 can be obtained in leafy greens and lentils; and B6 can be obtained in potatoes, chickpeas, and bananas; while B12 can be obtained in dairy products and organ meats.   For breakthroughs in slowing aging, scientists must look beyond biology University of Southern California, February 22, 2021 A trio of recent studies highlight the need to incorporate behavioral and social science alongside the study of biological mechanisms in order to slow aging. The three papers, published in concert in Ageing Research Reviews, emphasized how behavioral and social factors are intrinsic to aging. This means they are causal drivers of biological aging. In fact, the influence of behavioral and social factors on how fast people age are large and meaningful. However, geroscience--the study of how to slow biological aging to extend healthspan and longevity--has traditionally not incorporated behavioral or social science research. These papers are by three pioneers in aging research and members of the National Academy of Medicine who study different aspects of the intersection of biology and social factors in shaping healthy aging through the lifespan. Improving translation of aging research from mice to humans Exciting biological discoveries about rate of aging in non-human species are sometimes not applicable or lost when we apply them to humans. Including behavioral and social research can support translation of geroscience findings from animal models to benefit humans, said Terrie Moffitt, the Nannerl O. Keohane University Professor of Psychology and Neuroscience at Duke University. "The move from slowing fundamental processes of aging in laboratory animals to slowing aging in humans will not be as simple as prescribing a pill and watching it work," Moffitt said. "Compared to aging in laboratory animals, human aging has many behavioral/social in addition to cellular origins and influences. These influences include potential intervention targets that are uniquely human, and therefore are not easily investigated in animal research." Several of these human factors have big impacts on health and mortality: stress and early life adversity, psychiatric history, personality traits, intelligence, loneliness and social connection, and purpose in life are connected to a variety of late-life health outcomes, she explained. These important factors need to be taken into account to get a meaningful prediction of human biological aging. "Geroscience can be augmented through collaboration with behavioral and social science to accomplish translation from animal models to humans, and improve the design of clinical trials of anti-aging therapies," Moffitt said. "It's vital that geroscience advances be delivered to everyone, not just the well-to-do, because individuals who experience low education, low incomes, adverse early-life experiences, and prejudice are the people who age fastest and die youngest." Social factors associated with poor aging outcomes "Social hallmarks of aging" can be strongly predictive of age-related health outcomes - in many cases, even more so than biological factors, said USC University Professor and AARP Chair in Gerontology Eileen Crimmins. While the aging field commonly discusses the biological hallmarks of aging, we don't tend to include the social and behavioral factors that lead to premature aging. Crimmins has called the main five factors below "the Social Hallmarks of aging" and poses that these should not be ignored in any sample of humans and the concepts should be incorporated where possible into non-human studies. Crimmins examined data that was collected in 2016 from the Health and Retirement Study, a large, nationally representative study of Americans over the age of 56 that incorporates both surveys regarding social factors and biological measurements, including a blood sample for genetic analysis. For the study, she focused the five social hallmarks for poor health outcomes: low lifetime socioeconomic status, including lower levels of education adversity in childhood and adulthood, including trauma and other hardships being a member of a minority group adverse health behaviors, including smoking, obesity and problem drinking adverse psychological states, such as depression, negative psychological outlook and chronic stress The presence of these five factors were strongly associated with older adults having difficulty with activities of daily living, experiencing problems with cognition, and multimorbidity (having five or more diseases). Even when controlling for biological measurements - including blood pressure, genetic risk factors, mitochondrial DNA copy number and more - the social differences, as well as demographic factors such as age and gender, explained most of the differences in aging outcomes between study subjects, she said. However, biological and social factors aren't completely independent from one another, Crimmins added, which is why she advocates for further incorporation of social and behavioral factors in aging biology research. "Variability in human aging is strongly related to the social determinants of aging; and it remains so when extensive biology is introduced as mediating factors. This means that the social variability in the aging process is only partly explained by the biological measures researchers currently use," she said. "Our hypothesis is that if we could fully capture the basic biological mechanisms of aging, they would even more strongly explain the social variability in the process of aging, as social factors need to 'get under the skin' through biology." Understanding stress and stress resilience Elissa Epel, professor and vice chair in the Department of Psychiatry and Behavioral Sciences at UC San Francisco, detailed how research on stress and resilience needs to incorporate psychosocial factors in order to understand how different kinds of stress affect aging. Not all types of stress are equal and in fact some are salutary. The social hallmarks of aging can shape the rate of aging in part through toxic stress responses, she said. While acute responses to minor or moderate stressors, including infection or injury, is critical to survival, chronic exposure to high amounts of stress--including long-term psychological stressors such as abuse--can prove toxic and result in poor health outcomes. "Brief, intermittent, low-dose stressors can lead to positive biological responses, improving resistance to damage, which is called hormesis," Epel explained. For example, physiological hormetic stressors include short term exposure to cold, heat, exercise, or hypoxia. Hormetic stress turns on mechanisms of cell repair and rejuvenation. "In contrast, a high dose of a chronic exposure can override these mechanisms, resulting in damage or death," she added. Thus, toxic stress can accelerate biological aging processes, whereas hormetic stress can slow aging. However, the types, timing, and frequency of hormetic stress need to be better delineated in order to be useful to human aging research and interventions, Epel said. "Stress resilience, an umbrella term including hormetic stress, can be measured across cellular, physiological, and psychosocial functioning," she said. "Developing a deeper understanding of stress resilience will lead to more targeted innovative interventions." Stress resilience can also include social interventions that protect from the malleable social hallmarks of aging, including safe neighborhoods to reduce trauma and violence, and social support programs to combat loneliness and depression. Geroscience is now more important than ever, both to our aging global demography but also to the health challenges we face going forward, and stress resilience is an especially important topic at the moment, Epel added. "In our new era, we have dramatically increasing temperature extremes, wildfires and small particle pollution, and new zoonotic viruses to contend with intermittently," she said. "Reducing social disparities, improving stress resilience and bolstering immune function have become critical public health goals." In sum, the three papers together point to a promising decade ahead for aging research. Humans, as complex social mammals, age together in response to social conditions and behavioral factors that are partly malleable. Epel explains "As we discover and test biological processes of aging that we can manipulate, we can do this in tandem with capitalizing on the natural levers of healthy aging that are powerful, interactive, and cannot be ignored. In this way, the fountain of youth becomes more attainable."   Up to 10 portions of fruit and vegetables a day may prevent 7.8 million premature deaths Imperial College London, February 22, 2021 A fruit and vegetable intake above five-a-day shows major benefit in reducing the chance of heart attack, stroke, cancer and early death. This is the finding of new research, led by scientists from Imperial College London, which analysed 95 studies on fruit and vegetable intake. The team found that although even the recommended five portions of fruit and vegetables a day reduced disease risk, the greatest benefit came from eating 800g a day (roughly equivalent to ten portions - one portion of fruit or vegetables if defined as 80g). The study, which was a meta-analysis of all available research in populations worldwide, included up to 2 million people, and assessed up to 43,000 cases of heart disease, 47,000 cases of stroke, 81,000 cases of cardiovascular disease, 112,000 cancer cases and 94,000 deaths. In the research, which is published in the International Journal of Epidemiology, the team estimate approximately 7.8 million premature deaths worldwide could be potentially prevented every year if people ate 10 portions, or 800 g, of fruit and vegetables a day. The team also analysed which types of fruit and vegetables provided the greatest protection against disease. Dr Dagfinn Aune, lead author of the research from the School of Public Health at Imperial explained: "We wanted to investigate how much fruit and vegetables you need to eat to gain the maximum protection against disease, and premature death. Our results suggest that although five portions of fruit and vegetables is good, ten a day is even better." The results revealed that even a daily intake of 200g was associated with a 16 per cent reduced risk of heart disease, an 18 per cent reduced risk of stroke, and a 13 per cent reduced risk of cardiovascular disease. This amount, which is equivalent to two and a half portions, was also associated with 4 per cent reduced risk in cancer risk, and 15 per cent reduction in the risk of premature death. Further benefits were observed with higher intakes. Eating up to 800g fruit and vegetables a day - or 10 portions - was associated with a 24 per cent reduced risk of heart disease, a 33 per cent reduced risk of stroke, a 28 per cent reduced risk of cardiovascular disease, a 13 per cent reduced risk of total cancer, and a 31 per cent reduction in dying prematurely. This risk was calculated in comparison to not eating any fruit and vegetables. The team were not able to investigate intakes greater than 800 g a day, as this was the high end of the range across studies. An 80g portion of fruit and vegetables equals approximately one small banana, apple, pear or large mandarin. Three heaped tablespoons of cooked vegetables such as spinach, peas, broccoli or cauliflower count as a portion. The researchers also examined the types of fruit and vegetables that may reduce the risk of specific diseases. They found the following fruits and vegetables may help prevent heart disease, stroke, cardiovascular disease, and early death: apples and pears, citrus fruits, salads and green leafy vegetables such as spinach, lettuce and chicory, and cruciferous vegetables such as broccoli, cabbage and cauliflower. They also found the following may reduce cancer risk: green vegetables, such as spinach or green beans, yellow vegetables, such as peppers and carrots, and cruciferous vegetables. Similar associations were observed for raw and cooked vegetables in relation to early death, however, additional studies are needed on specific types of fruits and vegetables and preparation methods. The team say the number of studies was more limited for these analyses, and the possibility that other specific fruits and vegetables may also reduce risk cannot be excluded. Dr Aune said that several potential mechanisms could explain why fruit and vegetables have such profound health benefits: "Fruit and vegetables have been shown to reduce cholesterol levels, blood pressure, and to boost the health of our blood vessels and immune system. This may be due to the complex network of nutrients they hold. For instance they contain many antioxidants, which may reduce DNA damage, and lead to a reduction in cancer risk." He added that compounds called glucosinolates in cruciferous vegetables, such as broccoli, activate enzymes that may help prevent cancer. Furthermore fruit and vegetables may also have a beneficial effect on the naturally-occurring bacteria in our gut. The vast array of beneficial compounds cannot be easily replicated in a pill, he said: "Most likely it is the whole package of beneficial nutrients you obtain by eating fruits and vegetables that is crucial is health. This is why it is important to eat whole plant foods to get the benefit, instead of taking antioxidant or vitamin supplements (which have not been shown to reduce disease risk)." In the analysis, the team took into account other factors, such as a person's weight, smoking, physical activity levels, and overall diet, but still found that fruit and vegetables were beneficial. Dr Aune added: "We need further research into the effects of specific types of fruits and vegetables and preparation methods of fruit and vegetables. We also need more research on the relationship between fruit and vegetable intake with causes of death other than cancer and cardiovascular disease. However, it is clear from this work that a high intake of fruit and vegetables hold tremendous healthbenefits, and we should try to increase their intake in our diet."   Alpha-lipoic acid an effective antioxidant for healthy adult dogs Hills Pet Nutrition Research, February 19, 2021 According to news reporting originating from the Hill’s Pet Nutrition research stated, “This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs.” Our news reporters obtained a quote from the research from Hill’s Pet Nutrition: “Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated into four groups. Groups were then fed a nutritionally complete and balanced food with either 0, 75, 150 or 300 ppm of alpha-lipoic acid added for 6 months. Evaluations included physical examination, body weight, food intake, hematology, serum biochemistry profile and measurements of glutathione in plasma and erythrocyte lysates. Throughout, blood parameters remained within reference ranges, dogs were healthy and body weight did not change significantly. A significant increase of 0.05 ng/mL of total glutathione in red blood cell (RBC) lysate for each 1 mg/kg bodyweight/day increase in a-LA intake was observed. In addition, a significant increase was observed for GSH, GSSG and total glutathione in RBC lysate at Month 6.” According to the news editors, the research concluded: “We conclude that alpha-lipoic acid, as part of a complete and balanced food, was associated with increasing glutathione activity in healthy adult dogs.”

Według różnych danych, zaburzeń depresyjnych doświadcza 1-1,5 mln Polaków. Według WHO, depresja dotyka ponad 264 mln osób na całym świecie. To są jednak dane z 2017 i początku 2020 roku, jeszcze przed wybuchem pandemii koronawirusa, która — nie oszukujmy się — wpłynęła na wszystkich negatywnie, głównie z powodu poczucia niepokoju, izolacji społecznej. Z kolei, według raportu ONZ dotyczącego związku COVID-19 ze zdrowiem psychicznym, pandemia może jeszcze pogorszyć te statystyki, które i tak nie były optymistyczne. Mamy problem ze zdrowiem psychicznym i tym bardziej zatrważa dostępność do specjalistów ds. zdrowia psychicznego - zgodnie z raportem ONZ, w skali świata, na każde 10 tys. osób przypada mniej niż 1 specjalista ds. zdrowia psychicznego. Co z tym można zrobić? Jedną z rzeczy, które mają wpływ na nasz nastrój i w tym na rozwój zaburzeń depresyjnych ma dieta. W tym odcinku skupiam się na związku diety z rozwojem zaburzeń depresyjnych. Nie skupię się jednak na przyczynach depresji czy innych zaburzeń nastroju, bo jest ich wiele, a ja nie mam takiej wiedzy żeby tutaj się mądrzyć z pozycji eksperta. Nawiążę do kwestii osi mózg-jelito, jelito-mózg, o której mówiłam w poprzednim odcinku (#20.) i zachęcam do odsłuchania. Jeżeli masz pytania do tego odcinka napisz do mnie na malgorzata@pielichowska.pl Odwiedź moją stronę: https://pielichowska.pl Zostań moim patronem: https://patronite.pl/pielichowska Odwiedź mojego Facebooka: https://www.facebook.com/pielichowska.dietetyk Odwiedź mojego Instagrama: https://www.instagram.com/diet.and.mindfulness/ Literatura: Marx W., Lane M., Hockey M., i wsp. Diet and depression: exploring the biological mechanisms of action. Molecular Psychiatry, Nov 2020.Firth J., Marx W., Dash S. I wsp., The Effects of Dietary Improvement on Symptoms of Depression and Anxiety: A Meta-Analysis of Randomized Controlled Trials. Psychosomatic Medicine (2019) 81 (5): 265-280. Lassale C, Batty GD, Baghdadli A, Jacka F, Sánchez-Villegas A, Kivimäki M, Akbaraly T. Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies. Mol Psychiatry. 2019 Jul;24(7):965-986.Li Y, Lv MR, Wei YJ, Sun L, Zhang JX, Zhang HG, Li B. Dietary patterns and depression risk: A meta-analysis. Psychiatry Res. 2017 Jul; 253:373-382.Zheng L, Sun J, Yu X, Zhang D. Ultra-Processed Food Is Positively Associated With Depressive Symptoms Among United States Adults. Front Nutr. 2020 Dec 15;7:600449.Liu RT, Walsh RFL, Sheehan AE. Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials. Neurosci Biobehav Rev. 2019 Jul;102:13-23.https://www.foundmyfitness.com/topics/bdnf Olajossy M., Olajossy B., Wnuk S., i wsp. Stężenia kwasu kynureninowego w surowicy krwi pacjentów leczonych elektrycznie z rozpoznaniem zaburzenia depresyjnego nawracającego i depresji w przebiegu choroby afektywnej dwubiegunowej oraz zaburzenia schizoafektywnego. Psychiatr. Pol. 2017; 51(3): 455–468Aly J., Engmann O. The Way to a Human's Brain Goes Through Their Stomach: Dietary Factors in Major Depressive Disorder. Front. Neurosci. (2020) 14:582853. https://www.un.org/sites/un2.un.org/files/un_policy_brief-covid_and_mental_health_final.pdfhttps://zdrowedane.nfz.gov.pl/pluginfile.php/266/mod_resource/content/1/nfz_o_zdrowiu_depresja.pdf

Dr Michael Stanton is a licensed Clinical Health Psychologist and Assistant Professor at California State University, East Bay. Dr. Stanton's research examines how stress affects health behaviors, and his clinical work integrates mindfulness with cognitive behavioral therapy to treat both mental and physical health problems.  A frequent presenter at both national and international scientific conferences, his articles have been published in such journals as Molecular Psychiatry, American Journal of Public Health, and Harvard Review of Psychiatry. Dr. Stanton is also a guest contributor to several Bay Area TV news stations, where he adds psychology expertise to the analysis of current events. He holds a Ph.D. in Clinical Psychology, with a focus in Behavioral Medicine from Duke University, completed his postdoctoral training at Stanford University, and received his B.A. from Brown University. 

  Vidcast:  https://youtu.be/fCEfcgUYoww   Nearly 4 extra years of education cuts a risk of alcohol dependence by 50%.  National Institutes of Health investigators draw this conclusion from their study of 780,000 participants.   The genetic markers linked to more education were not associated with less alcohol consumption but rather with less binge drinking, fewer memory gaps due to drinking, fewer drinks on average per drinking day, and a lower weekly intake of beer or hard cider.  Added education did link to more alcohol with meals and more wine consumption.   Our politicians now talk about extending public education to include 4 years of college or vocational training.  One benefit of these additional years after high school may be fewer Americans with alcohol addiction.   Rosoff et al. Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780,000 participants. Molecular Psychiatry, 2019 DOI: 10.1038/s41380-019-0535-9   #Highereducation #college #trades #alcoholism  

Reference: 1.Barone J, Roberts H. Caffeine consumption. Food and Chemical Toxicology. 1996;34(1):119-29. 2.Amin N, Byrne E, Johnson J, Chenevix-Trench G, Walter S, Nolte IM, et al. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Molecular Psychiatry. 2012;17(11):1116-29. 3.Svilaas A, Sakhi AK, Andersen LF, Svilaas T, Strom EC, Jacobs Jr DR, et al. Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. The Journal of nutrition. 2004;134(3):562-7. 4.Pulido R, Hernandez-Garcia M, Saura-Calixto F. Contribution of beverages to the intake of lipophilic and hydrophilic antioxidants in the Spanish diet. European journal of clinical nutrition. 2003;57(10):1275-82. 5. SELFnutritionData know what you eat. Nutrient data for this listing was provided by USDA SR-21. Coffee, brewed from grounds, prepared with tap water [Internet]. 2018. (accessed on May 5, 2020) Available from: https://nutritiondata.self.com/facts/beverages/3898/2 6.Teketay D. History, botany and ecological requirements of coffee. Walia. 1999;20:28-50. 7.Fredholm BB. Adenosine, adenosine receptors and the actions of caffeine. Pharmacology & toxicology. 1995;76(2):93-101. 8.Nehlig A, Daval J-L, Debry G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Research Reviews. 1992;17(2):139-70. 9.Dulloo A, Geissler C, Horton T, Collins A, Miller D. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. The American journal of clinical nutrition. 1989;49(1):44-50. 10.Bracco D, Ferrarra J-M, Arnaud MJ, Jequier E, Schutz Y. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. American Journal of Physiology-Endocrinology and Metabolism. 1995;269(4):E671-E8. 11.Huxley R, Lee CMY, Barzi F, Timmermeister L, Czernichow S, Perkovic V, et al. Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Archives of internal medicine. 2009;169(22):2053-63. 12.Smith A. Effects of caffeine on human behavior. Food and chemical toxicology. 2002;40(9):1243-55. 13.Drake C, Roehrs T, Shambroom J, Roth T. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. Journal of Clinical Sleep Medicine. 2013;9(11):1195-200. 14.J. Boekema MS, GP van Berge Henegouwen, AJPM Smout, P. Coffee and gastrointestinal function: facts and fiction: a review. Scandinavian Journal of Gastroenterology. 1999;34(230):35-9. 15.Mattioli AV, Pennella S, Farinetti A, Manenti A. Energy Drinks and atrial fibrillation in young adults. Clinical Nutrition. 2018;37(3):1073-4. 16.สำนักโภชนาการ กรมอนามัย กระทรวงสาธารณสุข. รายงานการศึกษาวิจัยปี 2552 เรื่อง สารอาหารในกาแฟเย็นแคลอรี ของกาแฟแต่ละชนิด. ออนไลน์. ค้นเมื่อ 5 พฤษภาคม 2563. เข้าถึงได้จาก : http://nutrition.anamai.moph.go.th/images/file/สารอาหารในกาแฟเย็น.pdf 17.Dalle Grave R, Sartirana M, El Ghoch M, Calugi S. Module 1: Monitoring Food Intake, Physical Activity and Body Weight. Treating Obesity with Personalized Cognitive Behavioral Therapy: Springer; 2018. p. 45-58. 18.Min JE, Green DB, Kim L. Calories and sugars in boba milk tea: implications for obesity risk in Asian Pacific Islanders. Food science & nutrition. 2017;5(1):38-45. 19.Jura YH, Townsend MK, Curhan GC, Resnick NM, Grodstein F. Caffeine intake, and the risk of stress, urgency and mixed urinary incontinence. J Urol. 2011;185(5):1775-80. 20.Lachenmeier DW, Schwarz S, Teipel J, Hegmanns M, Kuballa T, Walch SG, et al. Potential antagonistic effects of acrylamide mitigation during coffee roasting on furfuryl alcohol, furan and 5-hydroxymethylfurfural. Toxics. 2019;7(1):1.

⟩⟩ Emotionaler Schmerz (z.B.: Trauer, Einsamkeit, Ablehnung) ist für viele Menschen kein angenehmes Gefühl. Im Gegenteil: wir tun oft alles, um diesem Gefühl komplett aus dem Weg zu gehen. Auf eine gewissen Weise ist sogar unser gesamtes (reaktives) Enneagramm-Muster dienlich, um uns vor emotionalem Schmerz zu bewahren. Wir wollen darüber sprechen (inkl. einiger Studien) wie diese Emotionswelt unseren Körper physisch verändert, welche Relevanz sie für uns hat und wie wir am besten damit umgehen können. --- Quellen: - How your emotions change the shape of your heart | Sandeep Jauhar -- https://youtu.be/mwoLhdHRt_0 - Hidden Brain — You 2.0: The Empathy Gym — July 29, 20193:00 PM ET https://www.npr.org/2019/07/22/744195502/you-2-0-the-empathy-gym — https://www.npr.org/transcripts/744195502 - Hidden Brain — ep. 68 „Schadenfacebook“ — https://www.npr.org/templates/transcript/transcript.php?storyId=524005057 - Hidden Brain — Looking Back - https://www.npr.org/2018/06/21/622298227/radio-replay-looking-back - Francesco Pelliccia, Juan Carlos Kaski, Filippo Crea, and Paolo G. Camici. Pathophysiology of Takotsubo Syndrome. Originally published13 Jun 2017https://doi.org/10.1161/CIRCULATIONAHA.116.027121 — https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.116.027121 - Christian Templin, Jürgen Hänggi, Carina Klein, Marlene S Topka, Thierry Hiestand, Rena A Levinson, Stjepan Jurisic, Thomas F Lüscher, Jelena-Rima Ghadri, Lutz Jäncke. Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome. European Heart Journal, Volume 40, Issue 15, 14 April 2019, Pages 1183–1187, https://doi.org/10.1093/eurheartj/ehz068 — https://academic.oup.com/eurheartj/article/40/15/1183/5366976/ - Aron, Arthur, Helen Fisher, Debra J. Mashek, Greg Strong, Haifang Li, and Lucy L. Brown. Reward, motivation, and emotion systems associated with early-stage intense romantic love. J Neurophysiol 94: 327–337, 2005; doi:10.1152/jn.00838.2004 — http://web.mit.edu/fustflum/documents/papers/love.pdf - Hsu, D. T., Sanford, B. J., Meyers, K. K., Love, T. M., Hazlett, K. E., Wang, H., … Zubieta, J.-K. (2013). Response of the μ-opioid system to social rejection and acceptance. Molecular Psychiatry, 18(11), 1211–1217. doi:10.1038/mp.2013.96 — http://sci-hub.tw/10.1038/mp.2013.96 - Starr CJ, Sawaki L, Wittenberg GF, et al. Roles of the insular cortex in the modulation of pain: insights from brain lesions. J Neurosci. 2009;29(9):2684–2694. doi:10.1523/JNEUROSCI.5173-08.2009 — https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748680/ - Eisenberger NI. The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. Nat Rev Neurosci. 2012 May 3;13(6):421-34. doi: 10.1038/nrn3231. — https://www.ncbi.nlm.nih.gov/pubmed/22551663 — http://icpla.edu/wp-content/uploads/2016/10/Eisenberger-N.-The-Pain-of-Social-Disconnection-Examining-the-shared-neural-underpinnings-of-physical-and-social-pain.pdf - Eisenberger NI. The neural bases of social pain: evidence for shared representations with physical pain. Psychosom Med. 2012;74(2):126–135. doi:10.1097/PSY.0b013e3182464dd1 -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273616/ - Segerstrom, S. C., & Miller, G. E. (2004). Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry. Psychological Bulletin, 130(4), 601–630. doi:10.1037/0033-2909.130.4.601 — https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361287/ - Cannon WB. "Voodoo" death. American Anthropologist, 1942;44(new series):169-181. Am J Public Health. 2002 Oct;92(10):1593-6; discussion 1594-5. PMID: 12356599. PMC1447285. DOI: 10.2105/ajph.92.10.1593 https://doi.org/10.1525/aa.1942.44.2.02a00010 --- ⟩⟩ Fragen und Anregungen zum Podcast: podcast@enneagramgermany.de

Our guest today, Nour Al-Muhtasib is a postdoctoral fellow in Molecular Psychiatry at Yale University. She is passionate about mental health, making academia more inclusive, and cats. Nour is the first of her family to earn a Ph.D. In addition, to writing Twitter threads discussing her experiences, she likes to write science parodies using hit songs such as Let it go and Truth Hurts.  Listen now to Nour's unique STEM story. In this episode we discuss: 1) What does Neuropharmacology & Molecular Psychiatry mean? 2) What does a Post Doctoral position entail? 3) What got Nour interested in this unique field of research? 4) How Nour found a way out of a toxic lab situation? Links: www.twitter.com/nouronal website- www.nouronal.com  

The Brain Warrior’s Way with Dr. Daniel G. Amen Dr. Daniel G. Amen believes that brain health is central to all health and success. When your brain works right, he says, you work right; and when your brain is troubled you are much more likely to have trouble in your life. His work is dedicated to helping people have better brains and better lives. The Washington Post called Dr. Amen the most popular psychiatrist in America and Sharecare named him the web’s #1 most influential expert and advocate on mental health. Dr. Amen is a physician, double board certified psychiatrist, television producer and ten-time New York Times bestselling author. He is the Founder and Medical Director of Amen Clinics across the US. Amen Clinics have the world’s largest database of functional brain scans relating to behavior, totaling more than 125,000 scans on patients from 111 countries. Dr. Amen is a Distinguished Fellow of the American Psychiatric Association, the highest award given to members, and is the lead researcher on the world’s largest brain imaging and rehabilitation study on professional football players. His research has not only demonstrated high levels of brain damage in players, he also showed the possibility of significant recovery for many with the principles that underlie his work. Together with Pastor Rick Warren and Dr. Mark Hyman, Dr. Amen is also one of the chief architects on Saddleback Church’s “Daniel Plan,” a program to get the world healthy through religious organizations. Dr. Amen has written, produced and hosted 11 popular shows about the brain for public television, which have been aired more than 100,000 times across North America. Dr. Amen is the author or co-author of 70 professional articles, seven book chapters, and over 30 books, including the #1 New York Times bestseller The Daniel Plan and Change Your Brain, Change Your Life, Magnificent Mind At Any Age, Change Your Brain, Change Your Body, Use Your Brain to Change Your Age, Unleash the Power of the Female Brain and Healing ADD. Dr. Amen’s published scientific articles have appeared in the prestigious journals of Molecular Psychiatry, PLOS One, Nature’s Translational Psychiatry, Nature’s Obesity, Journal of Neuropsychiatry and Clinical Neuroscience, Minerva Psichiatrica, Journal of Neurotrauma, American Journal of Psychiatry, Nuclear Medicine Communication, Neurological Research, Journal of the American Academy of Child and Adolescent Psychiatry, Primary Psychiatry, Military Medicine and General Hospital Psychiatry. Dr. Amen has appeared in movies, including After the Last Round and The Crash Reel and has appeared in Emmy winning shows, such as The Truth About Drinking and the Dr. Oz Show. He has also spoken for the National Security Agency (NSA), the National Science Foundation (NSF), Harvard’s Learning and the Brain Conference, the Department of the Interior, the National Council of Juvenile and Family Court Judges and the Supreme Courts of Delaware, Ohio and Wyoming. Dr. Amen’s work has been featured in Newsweek, Time, Huffington Post, ABC World News, 20/20, BBC, London Telegraph, Parade Magazine, New York Times, New York Times Magazine, Washington Post, LA Times, Men’s Health, Bottom Line, and Cosmopolitan. Website Link: 

A special episode, where Priscilla and Abi report back from the UKAAN Conference, that took place in September at The Mermaid, London. You can find out more about UKAAN by visiting their website: https://www.ukaan.org/ or Twitter: https://twitter.com/ukaan_orgIn true ADHD style we forgot to introduce the speakers during the vox pops, so here they are in order:1) Jane Sedgwick - Mueller (Tutor, Mental Health Nursing, King's College London).2) Ulrich Mueller - Sedgwick (Lead Clinician for Barnet, Enfield and Haringey Mental Health NHS Trust ADHD Service, North London).3) Philip Asherson (Professor of Molecular Psychiatry, King's College London, interviewed by Poppy Ellis Logan).4) Pravina Rudra (Journalist).5) Recap with Priscilla Eyles and Abi Silvester.Recorded September 2019.Music by Ian Chattam (can be found at https://soundcloud.com/sack-of-soul).Produced by: Priscilla Eyles, Abi Silvester, James Sarek and Neli Urruela.

In today's episode I talk with Julia Ross about her newest book, "The Craving Cure". Julia has combined 40 years of experience as a licensed psychotherapist with 30 years of pioneering work in the field of nutritional therapy to develop effective treatments for mood problems, eating disorders and addictions. She is the also the author of the best-selling books, "The Mood Cure" and "The Diet Cure". She has founded and directed integrative treatment programs in the San Francisco Bay Area since 1980 and currently oversees a virtual clinic for food cravings and insomnia. Julia lectures widely to health professionals and the public and directs training and certification programs through The Neuro-Nutrient Therapy Institute (NNTI). Her work has been featured in publications from "Vogue" to "The Journal of Molecular Psychiatry" as well as on radio, television and online. Julia's Website: https://www.juliarosscures.com/ The Craving Type Questionnaire: https://www.juliarosscures.com/craving-type-questionnaire/ Thanks for listening! If you enjoyed this episode and were inspired in some way, I would love to hear from you. Take a screenshot of you listening on your device, post it to your Instagram Stories and tag me @unsweetenedsio. 5 star ratings and positive reviews really help the podcast too! Website: www.unsweetenedsio.com Instagram: https://www.instagram.com/unsweetenedsio/ Facebook: https://www.facebook.com/unsweetenedsio Twitter: https://twitter.com/UnSweetenedSio YouTube: https://www.youtube.com/channel/UCYVw0_4Ms1GNE5-p6LT0qlw LinkedIn: https://www.linkedin.com/in/siobhan-harris-64663317/

A fair number of the patients I see are already eating a healthy diet but they’re still not feeling well. Once we delve deep into their history and their lives, it becomes very clear that stress is at the bedrock of their illness. It’s extremely frustrating to be eating well all the time but still experiencing symptoms. We know that stress shuts down digestion including suppression of stomach acid, bile flow, and pancreatic function. All of these are necessary for healthy digestion but if we’re stressed while we are eating, that healthy food we’re putting into our bodies won’t get digested properly and it may have some more interesting effects on the body. Stress also immediately changes the behavior of your gut bacteria which also influences how your food is digested and absorbed. I decided to look deeper into this connection and I found a very interesting paper entitled, “Depression, Daily Stressors, and Inflammatory Responses to High-Fat Meals: When Stress Overrides Healthier Food Choices.” The paper was published in the journal Molecular Psychiatry in March of 2017. Let’s dig in and break down what the researchers found. 58 healthy women with a mean age of 53 received either a high saturated fat meal or a high oleic sunflower oil meal. An inventory of stressful events was assessed prior to consuming the meal. The researchers found as expected that women without any prior day stressors showed increased signs of inflammation after the high saturated fat meal but no increase in inflammation after the sunflower oil meal. This is expected because too much saturated fat increases inflammation and monounsaturated oils that are high in oleic acid such as sunflower oil or olive oil do not increase inflammation when eaten in excess. In fact, olive oil has been shown in studies not to increase inflammation when eaten in excess and also it has been shown to decrease inflammation. However, any of the women who had prior day stressors showed an increase in inflammation after eating the high saturated fat meal as well as the high sunflower oil meal. The results looked identical after eating both types of fat. This clearly showed that if you have been under stress, eating fats that don’t increase inflammation such as sunflower or olive oil will still increase inflammation. They also found that the more daily stressors the subjects had leading up to the meals, the greater the levels of inflammation after the sunflower oil meal but not the saturated fat meal. So saturated fat had a cut-off effect when more stressors were accumulated. Additionally, any of the women who had a history of major depressive disorder showed an abnormal increase in blood pressure after the high-fat meal of both types. The authors go on to discuss how this increase in inflammation promotes plaquing of the arteries and can lead to diabetes by increasing insulin resistance. The authors also discuss the connection between a history of depression and how people respond to stressors. Those with any history of depression or PTSD show an amplified response to stressors compared to those without such history. Previous studies have also shown that marital stress can lead to higher insulin and triglyceride levels post-meal. What did they eat? The subjects at eggs, turkey sausage, biscuits, and gravy which contained 60 grams of fat, 59 grams of carbohydrates, and 36 grams of protein. The authors point out that these types of numbers are similar to that of a Burger King Double Whopper with cheese or a Big Mac cheeseburger and medium French fries. How was inflammation measured? Blood testing included CRP(c-reactive protein), serum amyloid A, sICAM-1, and sVCAM-1. SICAM-1 and sVCAM-1 are specific indicators of increased damage to arteries thus potentially leading to atherosclerosis. Dr. Hedberg’s Comments It is interesting that more daily stressors did not increased inflammation above a certain point in those who ate the high satu...

Is it possible to take the guesswork out of the prescription of medication for psychosis? Medication is available for the distressing experiences of hallucinations or delusions, but anti-psychotics only work for about three quarters of people and psychiatrists currently have no good way of working out who those people are. New research at Kings College London is trialling a type of scan that's been around for some time - a PET scan - but using it in a new way to detect whether a person's brain has an overactive dopamine system which might be able to predict which drugs will work. Claudia Hammond talks to Oliver Howes, Professor of Molecular Psychiatry, King's College London and Sameer Jauhar, Senior Research Fellow, King's College London who've been conducting this game changing research. We hear from the latest finalist in the All in the Mind Awards - someone who knows just what it's like to struggle for many years with mental health issues and to deal with some of worst things that can happen in life. Douglas, who's had to deal with a combination of physical and mental pain, nominated his GP Jens Foell for an award in the Professional category. What type of personality dictates whether we're prepared to stand up to someone dropping litter, chatting during a movie or more serious transgressions such as verbal abuse? It takes a certain type of person to say something, rather than to sit there and fume. So who is the most likely to stand up to anti-social behaviour? Markus Brauer, who's Professor of Social Psychology at the University of Wisconsin Madison, has been investigating just that. How did he go about it?

082 | Discoveries: contending with the superbugs  Welcome to another episode of Biotechnology Focus radio! I am your host – Michelle Currie – here to give you the rundown on what’s happening on the Canadian biotech scene. This week there have been some novel research discoveries that McMaster University, The University of Alberta, The University of British Columbia, The University of Waterloo and The University of Manitoba have been pumping out that I would like to share with you. So, keep listening and find out what exciting stories are happening from coast to coast!   +++++  Researchers from McMaster University have pinpointed a gene that is the culprit for neurological disorders, including autism.  They found that modifications of the gene thousand and one amino-acid kinase 2, aka TAOK2, has a direct link to these disorders. This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. This is the first comprehensive study that supports previous research suggesting the involvement of this gene and is published in Molecular Psychiatry.  According to Karun Singh, study co-author and researcher with McMaster’s Stem Cell and Cancer Research Institute, “Our studies reveal that in complex brain disorders that have a loss of many genes, a single deleted gene is sufficient to cause symptoms for the patients. This is exciting because it focuses our research effort on the individual gene, saving time and money as it will speed up the development of targeted therapeutics to this gene alone.”  Many neurodevelopmental disorders are caused by large missing pieces of genetic material in a person’s genome that contain several genes, termed a ‘microdeletion’. Accurately diagnosing a gene microdeletion helps doctors to predict patient outcome and to determine if a new treatment is available.  The researchers used genetically engineered models and computer algorithms to study a human genome, which allowed them to pinpoint the single gene in question.  The next step will be to screen candidate drugs that correct the cognitive brain deficits cause by genetic mutations in TAOK2, and identify candidates for pilot clinical trials.  The paper complements a study led by Singh on gene microdeletion published in American Journal of Human Genetics in early February.  The research was led by Singh in collaboration with Stephen Scherer from the Hospital for Sick Children. Additional researchers came from McMaster University, the Hospital for Sick Children, University of Toronto, the University Medical Center Hamburg-Eppendorf in Germany, Assiut University in Egypt and the University of Helsinki in Finland.  +++++  There was a time when the thought of growing a human body part in a lab would have been outrageous. These days, those once incredulous thoughts have become a reality.  Now, the researchers from the University of Alberta have found a way to grow human nose cartilage that will be safer and more accessible to use for facial reconstruction surgeons and will mean fewer surgeries and less pain for patients.  The team conducting the research project used a clinically approved collagen biomaterial as a scaffold to grow new cartilage that they can harvest and shape for patients who need nasal reconstruction.  The vision is that the surgeon would simply take a small biopsy of cartilage from inside the nose and provide it to the lab. The lab would then manufacture the cartilage for the surgeon in the appropriate shape and size. Once it has finished growing, the surgeon would then take that cartilage and insert it into the patient’s nose at the time of the operation.  Nasal reconstruction is a relatively common surgical outcome resulting from skin cancer. In 2015, there were more than three million cases of skin cancer in North America alone. About one-third of cases occur on a patient’s nose, with treatment options often leading to loss of function and disfigurement.  This typically ends up being a very traumatic event for the patient and comes with a high pathological cost. They really can’t hide these defects – they are very obvious. Often these patients will not interact socially because they are embarrassed by their appearance. So, the ability to help reconstruct a patient’s nose is really important.  With the assistance of six cartilage donors, the researchers harvested the cartilage cells – known as nasal chondrocytes – and multiplied them in a lab. They then seeded the cells in a scaffold to grow new tissue in a bioreactor. It takes roughly six weeks to grow enough cartilage for nasal reconstruction.  This engineered cartilage minimizes other risks and is deemed to be a superior method than that of the cartilage harvesting from the rib or ear. Cartilage taken from the rib carries a greater chance of infection, potentially collapsing the lung and an unnecessary surgery that will take the patient a longer to recuperate. Rib cartilage can also undergo warping after nasal reconstruction surgery, meaning it may not maintain the shape the surgeon wants it to. Cartilage taken from the ear is also challenging in that it can become brittle and difficult for the surgeon to manipulate. Engineered cartilage eliminates those deficiencies and could potentially supply unlimited quantities for surgeons. The University of Alberta team says it can also be custom-made for the patient.  An associate professor of surgery at the University of Alberta describes it as kind of like when you go to the tailor to get your suit made. They measure the patient based on the digital scans, and then basically just populate the cells.  The researchers have yet to test their high-quality engineered nasal cartilage in human patients. They hope that within the next two years they can begin clinical trials to prove the efficacy of the cartilage in the operating room.  +++++    Recent research conducted by the University of British Columbia (UBC)and BC Cancer denotes that precancerous lesions in the mouths of non-smokers are more likely to evolve into cancer than smokers.  Even though smoking unequivocally is related to mouth cancers, UBC dentistry PhD candidate Leigha Rock found that precancerous lesions in non-smokers are more than twice as likely to progress to cancer at an even faster rate than a smoking-associated counterpart. The study was published in Oral Oncology.  This is the first published study where the main focus was to examine the difference in risk of progression to oral cancer between non-smokers and smokers with oral precancerous lesions. While other studies have also reported a higher rate of transformation among non-smokers, this study looked at multiple risk factors including genetic markers.  Rock and colleagues looked at the case history of 445 patients with oral epithelial dysplasia (OED), a type of precancerous oral lesion, enrolled in the B.C. Oral Cancer Prediction Longitudinal study. One-third of the patients were non-smokers.  Amongst the researchers’ findings were that lesions on the floor of the mouth in non-smokers were 38 times more likely to progress to cancer than in smokers. This study is the first to report a quicker progression to cancer in non-smokers indicated at three-year and five-year rates of progression, and at 7 and 6.5 per cent higher than smokers, respectively.  The researchers suggest that the main difference in outcomes is due to a variance in the root causes of the lesions. In smokers, the oral epithelial dysplasia OED is likely the result of environmental factors. Whereas, in non-smokers, genetic susceptibility or mutations are likely to blame.  The findings show that molecular genomic markers can identify high-risk lesions, regardless of risky habits like smoking, and should be an important consideration in patient management.  The study’s results also stress the importance of taking oral lesions seriously, especially when they occur in non-smokers: “If you see a lesion in a smoker, be worried. If you see a lesion in a non-smoker, be very worried. Don’t assume it can’t be cancer because they’re a non-smoker; research indicates non-smokers may be at higher risk.”  This research was funded by the BC Cancer Foundation, the National Institutes of Health, and the National Institute of Dental and Craniofacial Research.  +++++  And some very exciting news, especially in this age of antimicrobial resistance, scientists from the University of Waterloo and the University of Manitoba have developed a new therapy to combat deadly bacteria that infects patients worldwide.  The new therapy is a biocide that targets an antibiotic-defiant bacterium such as Methicillin-resistant strafill cock us  are e us  (Staphylococcus aureus) (MRSA) to combat superbugs.  Professors at the University of Waterloo wanted to be able to help vulnerable patients suffering from chronic infections. Because once a patient is infected with a resistant strain of bacteria it is very difficult to get them well again.  This latest development provides hope in an age where bacteria are becoming resistant to antibiotics faster than researchers can develop new ones. The World Health Organization estimates 700,000 people die annually from antibiotic-resistant infections and they expect this toll to climb to 10 million by 2050, higher than the current death rate from cancer and even motor accidents combined.   University of Manitoba researcher, Song Liu, created a potent biocide that kills all bacterial cells – even the antibiotic-resistant ones. The biocide was limited to surface wounds due to its poor selectivity between bacterial and mammalian cells, but if they could deliver the biocide to a target inside the body, it would kill even the most resistant superbug.  Accompanying Liu’s work, Ho encased the biocide in solid-lipid nanoparticles and then added an antibody – a protein that would seek out Methicillin-resistant strafill cock us are e us bacteria over other cells. When the solid-lipid nanoparticles reach the bacteria, they release the biocide, killing the target but leaving healthy cells unaffected. The optimal outcome.  The results from the initial experiments appear to be quite promising. Still, there is a lot of work to do before this is available as an alternative to antibiotics. The next step is to find out whether the biocide gets released outside or inside the cell according to the researchers.   The researchers also believe that antimicrobial resistance will be unlikely to happen with their solid-lipid nanoparticles because the antibodies that are being used to target Methicillin-resistant strafill cock us are e us won’t cause the bacteria to develop an enzyme or other defence mechanisms in response.  This therapy offers a new line of defence in this critical time to confidently outpace antibiotic resistance.  +++++  Well, that’s it for this week’s episode of Biotechnology Focus radio. Perhaps next week there will be more riveting news from these universities and more from others I am sure. Modern medicine is advancing at such a pace, it’s hard to keep up! Be sure to check our website for the full stories and get your fill daily of what's happening on the Canadian biotech scene at www.biotechnologyfocus.ca. Thanks so much for listening in! Hope you have a great week ahead. From my desk to yours – this is Michelle Currie.   

Ahead on Biotechnology Focus radio are some of the stories from universities across the country and their innovative research this week. The University of British Columbia presents research that Alzheimer’s might be a whole-body problem. The University of Guelph identifies key protein in cancer metastasis. A University of Toronto scientist will be conducting a real-time study of astronauts while on mission. And, Western University’s National Centre for Audiology will be testing a device that may lay the foundation for hearing in the future. Welcome to another episode of Biotechnology Focus radio. I am your host, Michelle Currie, here to give you a run-down of the top stories of Canada’s biotech scene.  Our first story this week takes us to British Columbia, where recent studies are showing that Alzheimer’s might be linked to more than just deteriorating brain matter and plaque. It could be a whole-body phenomenon. The findings that were published in Molecular Psychiatry offer hope that future drug therapies might be able to stop or slow the disease without acting directly on the brain. Instead, the drugs might be able to target areas such as the liver and kidney to flush out the toxic proteins that cause dementia before ever reaching the brain. Weihong Song, a psychiatry professor from the university of British Columbia and Yan-Jiang Wang, a neurology professor at the Third Military Medical University in Chongqing, China, demonstrated the mobility of a protein linked to Alzheimer’s disease through a technique called parabiosis. The technique involves surgically attaching two specimens together so they share the same blood supply for several months. The scientists attached normal mice, which don’t naturally develop Alzheimer’s disease, with mice modified to carry a mutant human gene that produces elevated levels of the protein called amyloid beta. In people with Alzheimer’s disease, that protein ultimately forms clumps, or “plaque”. The findings described the mice who had been attached to an amyloid beta inflicted counterpart ended up “contracting” the disease, all in just a few months. Not only did the normal mice develop plaque, but also a “tangle”-like pathology, which are twisted protein strands that form inside brain cells that disrupt their function to eventually kill them from the inside-out. Other signs of Alzheimer’s-like damage included brain cell degeneration, inflammation, and microbleeds. Even the ability to transmit electrical signals involved in learning and memory were impaired after a brief time being joined. Amyloid beta is produced in other areas of the body besides the brain. It can be found in blood platelets, blood vessels, and muscles. Until these experiments, it was unclear if amyloid beta from outside the brain could contribute to Alzheimer’s disease. It appears from this study, that indeed it can. Perhaps in the near future, researchers and scientists will develop a drug that would tag the amyloid beta biochemically in such a way that the liver or kidney will be able to flush it out before generating damage. +++++++ The University of Guelph researchers have made a discovery during one of their ground-breaking studies. They have identified a protein known as cadherin-22 that binds cancer cells together and allows them to invade tissues. Hindering this protein showed signs of reduction in metastatic cancer patients for breast and brain cancer cells by up to 90 per cent. This study was published in the journal Oncogene and looks specifically at hypoxia in tumours. More solid cancer tumours that are depleted of oxygen, are difficult to treat and replicate at a faster rate. The researchers from the university discovered from the analysis of more than 100 patients with breast or brain cancer that there was a link between the quantity of cadherin-22 and the level of hypoxia in a tumour itself. The more hypoxic the tumour was, the higher the protein count of cadherin-22. Until now, little was known about how oxygen-deprived cancer cells bound together and interacted to spread. The U of G researchers found that it is precisely under conditions of low oxygen that cancer cells trigger the production of cadherin-22, putting in motion a kind of protein boost that helps bind cells together, enhancing cellular movement, invasion, and likely metastasis. The protein is found on the outside of cells and allows hypoxic cancer cells to migrate together. Scientists have known for decades that hypoxia plays a role in tumour growth and metastasis, as well as a poor patient outcome. Professor Jim Uniacke and his team identified that cadherin-22 plays an integral part in the advancement of cancer cells. The researchers used an incubator to monitor cancer cells in a low-oxygen environment comparable to a tumour, where the protein cadherin-22 had been removed via molecular tools. The cancer cells failed to spread. These findings offer vital insights into the aggression and migration of cancer cells. +++++++ A University of Toronto scientist will be performing real-time blood cell analyses on astronauts to reveal how time, space, and speed affect the immune system. Dr. Chen Wang hopes that this research will lead to an understanding of how stress and other environmental factors impact our ability to fight disease. Wang, a professor in the faculty of medicine’s department of laboratory medicine and pathobiology and a clinician-scientist at Mount Sinai Hospital, will be leading the project named Immuno Profile, to study the astronauts on the International Space Station over the course of five years. Canadian astronaut and physician, David Saint-Jacques, will be part of the next mission to the space station and will participate in several Canadian-made health experiments announced by the Canadian Space Agency. The astronauts will use a device that will take finger-prick blood samples during the flight mission, then the information will be sent back to Wang and his team for analysis. Wang expects to see immune cell and cytokine mediator changes, identify different types of immune cells and to see if the cells are functioning well or not. Wang also commented on the uniqueness of the space flight environment to study immune system stressors. Immune dysfunction relates to many diseases, including cancers, viral infections, MS, type I diabetes, and even the aging process. The weightlessness of space can also be used to learn more about the less-understood lymphatic system, which depends on the pressure to flow properly. They hope to develop a new model for how the immune system responds to circadian rhythm and various stresses. +++++++ Lastly for this week, Western University’s National Centre for Audiology (NCA) is testing a new device that may lay the foundation for the hearing of the future. Recently approved by Health Canada and already available in the states, Earlens hearing aid offers a remarkable chance for the hearing impaired to listen in to the everyday world. Its sound-to-light technology eliminates the whistling noise common in conventional hearing aids and delivers the broadest frequency on the market that results in a more life-like sound with crisp highs and rumbling lows. Western University is the first Canadian location authorized to test out the Earlens hearing aid and see if it measures up. Traditional hearing aids are worn behind the ear or in the ear and pick-up, amplify and process incoming sounds and direct them into the ear canal. Meanwhile, the Earlens rests directly on the eardrum and gently activates the natural hearing system. Western’s National Centre for Audiology is a state-of-the-art research centre. It has developed national protocols for pediatric heating assessments, developed methods for fitting hearing aids, has tested numerous devices for more than a dozen companies across the globe and is dedicated to tackling complex issues related to hearing loss. The NCA will be testing the Earlens device using a double-blind study to examine if its light pulse invention turns on the bulb to resonate a way to the future of hearing. ++++++++ Well that wraps up another episode of Biotechnology Radio. We hope you enjoyed it. If you have any feedback or story ideas, please reach out to us via press@promotivemedia.ca. From all of us here at Biotechnology Focus, have a wonderful week ahead. From my desk to yours – this is Michelle Currie.

ADHD - or attention deficit hyperactivity disorder - tends to be characterised by difficulties in concentrating, impulsivity, and hyperactivity. Claudia Hammond talks to Philip Asherson, Professor of Clinical and Molecular Psychiatry at Kings College London and a consultant at the Maudsley Hospital in London, who has recently published research that shows that excessive mind-wandering might be at its core. She also hears from two teenage girls with ADHD about their experience of mindwandering during school lessons. it's not at all unusual for people with depression to have difficulty sleeping. Now a trial has focussed on treating the insomnia in the hope that it improves the depression, rather than vice versa. Professor of Mental Health, Helen Christensen, and Dr Aliza Werner-Saidler, a Research Fellow and Clinical Psychologist at the Black Dog Institute at the University of New South Wales in Australia, showed Claudia Hammond how an online programme called SHUTi - developed by the University of Virginia and commercially available - helped people with insomnia and depression. Two years ago on All in the Mind we debated the merits of a new scheme to get more high-flying graduates into the mental health field. Called Think Ahead it follows in the footsteps of similar schemes like Teach First. This time top graduates train, mostly on the job, to become mental health social workers. Claudia finds out how two of the first graduates are getting on in the their first placements.

Do you think your child may be introverted?  Or are you not sure how to tell?  Around one in three people are introverted so if you have two or three children, chances are one of them is introverted.  While Western – and particularly American – society tends to favor extroverts, being an introvert isn’t something we can – or should – cure.  It’s a personality trait, not a flaw. Join me as we walk through a topic near and dear to my heart, and learn the difference between introversion and shyness, and how to support your introverted child – no matter whether you yourself are introverted or extroverted. References Aron, E.N. (1996). Are you highly sensitive? Retrieved from: http://hsperson.com/test/highly-sensitive-test/ Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009). Vulnerability genes or plasticity genes? Molecular Psychiatry 14, 746-754. DOI: 10.1038/mp.2009.44 Cain, S. (2013). Quiet: The power of introverts in a world that can’t stop talking. New York: Broadway. Dobbs, D. (2009). The science of success. The Atlantic. Retrieved from: http://www.theatlantic.com/magazine/archive/2009/12/the-science-of-success/307761/ Kagan, J., & Snidman, N. (2004). The long shadow of temperament. Cambridge, MA: Harvard University Press Keogh, B.K. (1986). Temperament and schooling: Meaning of “Goodness of Fit”? In J.V. Lerner and R.M. Lerner (Eds). Temperament and social interaction in infancy and children. San Francisco, Jossey-Bass. Laney, M.O. (2002).  The introvert advantage: How to thrive in an extrovert world. New York: Workman. Markway, B.G., & Markway, G.P. (2005). Nurturing the shy child: Practical help for raising confident ans socially skilled kids and teens. New York: St. Martin’s. McCrae, R.R., & Terracciano, A. (2006). National character and personality. Current Directions in Psychological Science 15(4), 156-161. Pluess, M., & Belsky, J. (2009). Differential susceptibility to rearing experience: The case of childcare. Journal of Child Psychology and Psychiatry 50(4), 396-404. DOI: 10.1111/j.1469-7610.2008.01992.x Pluess, M., & Belsky, J. (2010). Differential susceptibility to parenting and quality child care. Developmental Psychology 46(2), 379-390. DOI: 10.1037/a0015203 Similarminds.com (a version of Eysenck’s Personality Inventory). Retrieved from: http://similarminds.com/eysenck.html Swallow, W.K. (2000). The shy child: Helping children triumph over shyness. New York: Warner. Swann, W.B. & Rentfrow, P.J. (2001). Blirtatiousness: Cognitive, behavioral, and physiological consequences of rapid responding. Journal of Personality and Social Psychology 81(6), 1160-1175. DOI: 10.1037//0022-35I4.81.6.1160 Thomas, A., & Chess, S. (1977). Temperament and development. New York: Brunner/Mazel.   (#) Transcript Hello and welcome to the Your Parenting Mojo podcast.  Before we get started today I’d like to take a few minutes to chat with you about the podcast.  Firstly, I’d like to thank you so much for listening to the show.  I’ve been really honored over the last few weeks since I started the show to hear from so many of you about how much the show is helping you in your parenting.  Because at the end of the day, I’m getting a masters degree in Psychology focusing on child development to be a better parent myself, and to help you be better parents as well.  There’s just too much good information out there about how this whole parenting thing works for us to kind of bumble along and not know any better.  And I put myself in the same boat as you here; I’m literally learning this stuff with you as I go.  I don’t always handle things in the best way but when I learn better I do better, and I forgive myself for having done things “the old way.”  I’m growing and becoming a better parent because of what I’m learning with you, and I’m honored

Meredith Rhodes and Roland Denzel join us to discuss News & Views. Stories include: the effectiveness of wearable fitness and diet trackers, what the gut microbiomes of obese kids tell us, whether stress erases the benefits of a healthy diet, and what we can learn from a new Blue Zone identified in southern Italy. The Moment of Paleo segment throws around ideas about working to get ahead. After the Bell features Dan Ariely, professor of economics, discussing whether we are really in control of our own decisions. Links for this episode:Get the Latest in Paleo Health News Ticker!This Episode at latestinpaleo.comRecommended Books & AudiobooksForward Health Coach |Meredith (@geomert) | TwitterAdventures in Humaning | Free Listening on SoundCloudFacebook - Adventures In HumaningFacebook - Eat Well Move WellEat Well Move Well™ – #EatMoveLive52 – Better In A Week!Roland Denzel (@rolanddenzel) | TwitterEffect of Wearable Technology Combined With a Lifestyle Intervention on Long-term Weight Loss:  The IDEA Randomized Clinical Trial | Sep 20, 2016 | JAMA | JAMA NetworkYour Wearable Won’t Help You Lose Weight | TIMECould your fitness tracker sabotage your diet? - CNN.comObese Kids Have Different Germs in Their Gut | Health Care | US NewsObese Kids Have Unique Set of Gut BacteriaGut Bacteria Could Be Making Kids Fat | MotherboardAccess : Depression, daily stressors and inflammatory responses to high-fat meals: when stress overrides healthier food choices : Molecular PsychiatryChill Out, Ladies. Stress Can Erase the Benefits of Your Healthful Diet | Sci-Tech TodayStress May Counteract Effects of a Healthful Diet - The New York Times?A tough day could erase the perks of choosing ‘good’ fat sources, study finds | News Room - The Ohio State UniversityHow to live to 100: Town of centenarians spills secrets - CNN.comDan Ariely: Are we in control of our own decisions? | TED Talk | TED.comVisit PuraKai to shop for eco-friendly clothing and stand-up paddle boards. Be sure to use coupon code "latest in paleo" for 15% off all clothing purchases.

In this episode we're joined by Michael Honsberger, neuroscientist and STEM project manager for Yale's Young Global Scholar's Program. Michael has a background studying memory including a PhD in behavioral neuroscience and a postdoc in Yale's Division of Molecular Psychiatry. He talks to us about how we can use knowledge of how the brain works to become better teachers.

This month the Australian and New Zealand Journal of Psychiatry examines the relationship between substance abuse and psychosis, with clinical articles regarding depression, anorexia nervosa, and the use of online resources and social media in early psychosis. Australasian Psychiatry has a report on involuntary community treatment in Australia. The American Journal of Psychiary examines links between ADHD and bipolar disorder, while the British Journal of Psychiatry features research on delays initiating clozapine in treatment-resistant schizophrenia, while Amminger and colleagues publish a letter in Molecular Psychiatry which speculates on possible mechanisms preventing transition to psychosis in high-risk patients on omega-3 fatty acid supplementation.