Out of the Blue: An AJRCCM Podcast

Dr. Michael Lanspa chats with Dr. Carmen Reep and Dr. Leo Heunks about their article, "Early vs. Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation."

This episode originally aired on January 17th, 2024. Dr. Michael Lanspa chats with Dr. Michael Matthay about his article, "A New Global Definition of Acute Respiratory Distress Syndrome."

Dr. Mohleen Kang chats with Dr. Kerri Johannson and Dr. Tamera Corte about their article, "Impact of Environmental Exposures on the Development and Progression of Fibrotic Interstitial Lung Disease."

Dr. John Fleetham chats with Dr. Sonal Munsiff and Dr. Raquel Duarte about their article, "Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline." 

Dr. John Fleetham chats with Dr. Paolo Denti, Dr. Elisa Ignatius, Dr. Jason Andrews, and Dr. Neil Schluger about two papers and an editorial published in AJRCCM discussing the use of isoniazid in treating patients with tuberculosis.

Dr. John Fleetham chats with Dr. Hedner and Dr. Schmickl about their articles “A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea" and  “Drug Therapy for Obstructive Sleep Apnea: Are We There Yet?” 

Dr. Mohleen Kang chats with Dr. Margaret Salisbury and Dr. Anna Podolanczuk about their articles, "Progressive Early Interstitial Lung Abnormalities in Persons at Risk for Familial Pulmonary Fibrosis: A Prospective Cohort Study" and "Big Things Have Small Beginnings: Clinical Implications of Early Interstitial Lung Disease." 

Dr. John Fleetham chats with Dr. Yet Kor about her article, "Assessment of Home-based Monitoring in Adults with Chronic Lung Disease: An Official American Thoracic Society Research Statement."

Dr. John Fleetham chats with Dr. Ludovico Messineo and Dr. Simon Joosten about their articles "Hypnotics on Obstructive Sleep Apnea Severity and Endotypes: A Systematic Review and Meta-Analysis" and "The Arousal Threshold: The ‘Weakest Link' in OSA Pathogenesis." 

Dr. Michael Lanspa chats with Dr. Hannah Wunsch about her paper, "Evaluation of Etomidate Use and Association with Mortality Compared with Ketamine among Critically Ill Patients."

Dr. Michael Lanspa chats with Dr. Anthony Gordon about his article, "From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU."

Dr. John Fleetham chats with Dr. Chris Ryerson and Dr. Yet Khor about their article, "Epidemiology and Prognostic Significance of Cough in Fibrotic Interstitial Lung Disease."

Dr. John Fleetham chats with Dr. Gozal on his article, "Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea."

Dr. John Fleetham chats with Dr. Bijan Teja and Dr. Nicholas Bosch about their article, "Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials." 

Dr. John Fleetham chats with Dr. Barbro N Melgert and Dr. Chris Carlsten about their articles, "Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation" and "Inhaled Microplastics and Airway Development: Concerning Evidence from Organoids."

Dr. Michael Lanspa chats with Dr. Michael Matthay about his article, "A New Global Definition of Acute Respiratory Distress Syndrome."

Dr. Mohleen Kang chats with Dr. Aparna Swaminathan and Dr. Timothy Dempsey about their articles, "External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real-World Data Sources” and “The Added Power of Synthetic Control Groups: Challenging Conventional Wisdom and Trial Design in Idiopathic Pulmonary Fibrosis Research.” 

Dr. John Fleetham chats with Dr. Paula K. Schweitzer and Dr. Najib Ayas about their articles, "The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial" and "Pharmacologic Therapy for Obstructive Sleep Apnea: Are We Seeing Some Light at the End of the Tunnel?"

Dr. John Fleetham chats with Dr. Surya Bhatt about his article, “FEV1/FVC Severity Stages for Chronic Obstructive Pulmonary Disease.”

Dr Michael Lanspa chats with Dr. Imeen van der Wal and Dr. Chloe Grim on their article, "Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial." 

Dr. John Fleetham chats with Dr. Raphael Heinzer about his article, "Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea."

Dr. Michael Lanspa chats with Dr. Kevin Seitz and Dr. Matthew Churpek about their article, "Individualized Treatment Effects of Bougie vs Stylet for Tracheal Intubation in Critical Illness."

Dr. John Fleetham chats with Dr. Molly Franke and Dr. James Brust about their articles, "Effectiveness of Bedaquiline Use Beyond Six Months in Patients with Multidrug-Resistant Tuberculosis" and “Weighting” the evidence: How much bedaquiline is enough?"

Dr. Michael Lanspa chats with Dr. Yahya Shehabi about his article, "Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)."

Dr. John Fleetham chats with Dr. Joseph Lewnard and Dr. Will Checkley about their articles, "Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California" and "Tuberculosis, Wildfires, and Case-crossover Studies: An Epidemiological Trifecta."

Paper discussed in today's episode:Assessing Pretomanid for Tuberculosis (APT), a Randomized Phase 2 Trial of Pretomanid-containing Regimens for Drug-sensitive TB: 12-Week Results

Papers discussed in today's episode:Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive SleepinessContinuous Positive Airway Pressure and Cardiovascular Risk Reduction in Patients without Excessive Sleepiness: Importance of the Pulse Rate Response

Paper discussed in today's episode:High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial

Article discussed in this episode:Autoimmune Pulmonary Alveolar Proteinosis

Article discussed in this episode:Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis

Article discussed in this episode:Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

Articles discussed in this episode:“A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea"“Drug Therapy for Obstructive Sleep Apnea: Are We There Yet?”

Article discussed in this episode:Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions 

Article discussed in this episode:Effect of Weight Loss and CPAP on OSA and Metabolic Profile Stratified by Craniofacial Phenotype: A Randomized Clinical Trial

Articles discussed in today's episode:A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis TreatmentA Semimechanistic Model of the Bactericidal Activity of High-Dose Isoniazid against Multidrug-Resistant Tuberculosis: Results from a Randomized Clinical TrialUsing Isoniazid More Safely and More Effectively: The Time Is Now [Editorial][Note: The episode was updated on February 24, 2022, to fix an audio editing error.]

Article discussed in today's episode:Multi-night Prevalence, Variability, and Diagnostic Misclassification of Obstructive Sleep Apnea 

Article discussed in today's episode: Alpha-1 Antitrypsin MZ Heterozygosity is an Endotype of Chronic Obstructive Pulmonary Disease

Article discussed in today's episode:Latent Class Analysis Reveals COVID-19–related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids

Article discussed in today's episode:Effect of Esophageal Pressure-Guided Positive End-Expiratory Pressure on Survival from Acute Respiratory Distress Syndrome: A Risk-Based and Mechanistic Reanalysis of the EPVent-2 Trial

Paper discussed in today's episode:An Association Between Positive Airway Pressure (PAP) Device Manufacturer and Incident Cancer?: A Secondary Data Analysis

Article discussed in today's episode:Association between Troponin I Levels during Sepsis and Postsepsis Cardiovascular Complications

Article discussed in today's episode: Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury

Article discussed in today's episode:Effect of Continuous Positive Airway Pressure on Arrhythmia in Atrial Fibrillation and Sleep Apnea: A Randomized Controlled Trial

Article discussed in today's episode:Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain