Out of the Blue: An AJRCCM Podcast

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The Out of the Blue podcast takes you out of the pages of the American Journal of Respiratory and Critical Care Medicine and into the minds of the most brilliant researchers in the fields of respiratory, critical care, and sleep medicine.

American Thoracic Society


    • May 29, 2025 LATEST EPISODE
    • every other week NEW EPISODES
    • 27m AVG DURATION
    • 176 EPISODES


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    Latest episodes from Out of the Blue: An AJRCCM Podcast

    Early vs. Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation

    Play Episode Listen Later May 29, 2025 24:15


    Dr. Michael Lanspa chats with Dr. Carmen Reep and Dr. Leo Heunks about their article, "Early vs. Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation."

    A New Global Definition of Acute Respiratory Distress Syndrome

    Play Episode Listen Later May 8, 2025 33:05


    This episode originally aired on January 17th, 2024. Dr. Michael Lanspa chats with Dr. Michael Matthay about his article, "A New Global Definition of Acute Respiratory Distress Syndrome."

    Impact of Environmental Exposures on the Development and Progression of Fibrotic Interstitial Lung Disease

    Play Episode Listen Later Apr 17, 2025 45:40


    Dr. Mohleen Kang chats with Dr. Kerri Johannson and Dr. Tamera Corte about their article, "Impact of Environmental Exposures on the Development and Progression of Fibrotic Interstitial Lung Disease."

    Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline

    Play Episode Listen Later Apr 3, 2025 16:04


    Dr. John Fleetham chats with Dr. Sonal Munsiff and Dr. Raquel Duarte about their article, "Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline." 

    Using Isoniazid More Safely and More Effectively in Tuberculosis Treatment

    Play Episode Listen Later Mar 20, 2025 34:40


    Dr. John Fleetham chats with Dr. Paolo Denti, Dr. Elisa Ignatius, Dr. Jason Andrews, and Dr. Neil Schluger about two papers and an editorial published in AJRCCM discussing the use of isoniazid in treating patients with tuberculosis.

    A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea

    Play Episode Listen Later Mar 13, 2025 23:59


    Dr. John Fleetham chats with Dr. Hedner and Dr. Schmickl about their articles “A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea" and  “Drug Therapy for Obstructive Sleep Apnea: Are We There Yet?” 

    Progressive Early Interstitial Lung Abnormalities in Persons At-Risk for Familial Pulmonary Fibrosis: A Prospective Cohort Study and Big Things Have Small Beginnings: Clinical Implications of Early Interstitial Lung Disease

    Play Episode Listen Later Feb 20, 2025 26:37


    Dr. Mohleen Kang chats with Dr. Margaret Salisbury and Dr. Anna Podolanczuk about their articles, "Progressive Early Interstitial Lung Abnormalities in Persons at Risk for Familial Pulmonary Fibrosis: A Prospective Cohort Study" and "Big Things Have Small Beginnings: Clinical Implications of Early Interstitial Lung Disease." 

    Assessment of Home-based Monitoring in Adults with Chronic Lung Disease: An Official American Thoracic Society Research Statement

    Play Episode Listen Later Feb 13, 2025 23:36


    Dr. John Fleetham chats with Dr. Yet Kor about her article, "Assessment of Home-based Monitoring in Adults with Chronic Lung Disease: An Official American Thoracic Society Research Statement."

    Hypnotics on Obstructive Sleep Apnea Severity and Endotypes: A Systematic Review and Meta-Analysis and The Arousal Threshold: The ‘Weakest Link' in OSA Pathogenesis?

    Play Episode Listen Later Dec 13, 2024 37:26


    Dr. John Fleetham chats with Dr. Ludovico Messineo and Dr. Simon Joosten about their articles "Hypnotics on Obstructive Sleep Apnea Severity and Endotypes: A Systematic Review and Meta-Analysis" and "The Arousal Threshold: The ‘Weakest Link' in OSA Pathogenesis." 

    Evaluation of Etomidate Use and Association with Mortality Compared with Ketamine among Critically Ill Patients

    Play Episode Listen Later Dec 6, 2024 33:14


    Dr. Michael Lanspa chats with Dr. Hannah Wunsch about her paper, "Evaluation of Etomidate Use and Association with Mortality Compared with Ketamine among Critically Ill Patients."

    From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU

    Play Episode Listen Later Oct 11, 2024 27:16


    Dr. Michael Lanspa chats with Dr. Anthony Gordon about his article, "From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU."

    Epidemiology and Prognostic Significance of Cough in Fibrotic Interstitial Lung Disease

    Play Episode Listen Later Sep 13, 2024 21:02


    Dr. John Fleetham chats with Dr. Chris Ryerson and Dr. Yet Khor about their article, "Epidemiology and Prognostic Significance of Cough in Fibrotic Interstitial Lung Disease."

    Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea

    Play Episode Listen Later Jun 5, 2024 32:44


    Dr. John Fleetham chats with Dr. Gozal on his article, "Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea."

    Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

    Play Episode Listen Later Mar 28, 2024 20:49


    Dr. John Fleetham chats with Dr. Bijan Teja and Dr. Nicholas Bosch about their article, "Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials." 

    Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation and Inhaled Microplastics and Airway Development: Concerning Evidence from Organoids

    Play Episode Listen Later Feb 21, 2024 25:59


    Dr. John Fleetham chats with Dr. Barbro N Melgert and Dr. Chris Carlsten about their articles, "Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation" and "Inhaled Microplastics and Airway Development: Concerning Evidence from Organoids."

    A New Global Definition of Acute Respiratory Distress Syndrome

    Play Episode Listen Later Jan 17, 2024 33:05


    Dr. Michael Lanspa chats with Dr. Michael Matthay about his article, "A New Global Definition of Acute Respiratory Distress Syndrome."

    External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real-World Data Sources and The Added Power of Synthetic Control Groups: Challenging Conventional Wisdom and Trial Design in Idiopathic Pulmonary Fibrosis Research

    Play Episode Listen Later Jan 16, 2024 32:50


    Dr. Mohleen Kang chats with Dr. Aparna Swaminathan and Dr. Timothy Dempsey about their articles, "External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real-World Data Sources” and “The Added Power of Synthetic Control Groups: Challenging Conventional Wisdom and Trial Design in Idiopathic Pulmonary Fibrosis Research.” 

    The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial and Pharmacologic Therapy for Obstructive Sleep Apnea: Are We Seeing Some Light at the End of the Tunnel?

    Play Episode Listen Later Dec 8, 2023 22:43


    Dr. John Fleetham chats with Dr. Paula K. Schweitzer and Dr. Najib Ayas about their articles, "The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial" and "Pharmacologic Therapy for Obstructive Sleep Apnea: Are We Seeing Some Light at the End of the Tunnel?"

    FEV1/FVC Severity Stages for Chronic Obstructive Pulmonary Disease

    Play Episode Listen Later Oct 5, 2023 16:21


    Dr. John Fleetham chats with Dr. Surya Bhatt about his article, “FEV1/FVC Severity Stages for Chronic Obstructive Pulmonary Disease.”

    Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial

    Play Episode Listen Later Sep 28, 2023 17:14


    Dr Michael Lanspa chats with Dr. Imeen van der Wal and Dr. Chloe Grim on their article, "Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial." 

    Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea

    Play Episode Listen Later Jul 20, 2023 20:38


    Dr. John Fleetham chats with Dr. Raphael Heinzer about his article, "Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea."

    Individualized Treatment Effects of Bougie vs Stylet for Tracheal Intubation in Critical Illness

    Play Episode Listen Later Jun 22, 2023 25:09


    Dr. Michael Lanspa chats with Dr. Kevin Seitz and Dr. Matthew Churpek about their article, "Individualized Treatment Effects of Bougie vs Stylet for Tracheal Intubation in Critical Illness."

    Effectiveness of Bedaquiline Use Beyond Six Months in Patients with Multidrug-Resistant Tuberculosis

    Play Episode Listen Later May 11, 2023 22:10


    Dr. John Fleetham chats with Dr. Molly Franke and Dr. James Brust about their articles, "Effectiveness of Bedaquiline Use Beyond Six Months in Patients with Multidrug-Resistant Tuberculosis" and “Weighting” the evidence: How much bedaquiline is enough?"

    Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)

    Play Episode Listen Later Mar 23, 2023 33:19


    Dr. Michael Lanspa chats with Dr. Yahya Shehabi about his article, "Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)."

    Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California

    Play Episode Listen Later Mar 2, 2023 17:48


    Dr. John Fleetham chats with Dr. Joseph Lewnard and Dr. Will Checkley about their articles, "Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California" and "Tuberculosis, Wildfires, and Case-crossover Studies: An Epidemiological Trifecta."

    Assessing Pretomanid for Tuberculosis (APT), a Randomized Phase 2 Trial of Pretomanid-containing Regimens for Drug-sensitive TB: 12-Week Results

    Play Episode Listen Later Dec 15, 2022 14:59


    Paper discussed in today's episode:Assessing Pretomanid for Tuberculosis (APT), a Randomized Phase 2 Trial of Pretomanid-containing Regimens for Drug-sensitive TB: 12-Week Results

    Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness

    Play Episode Listen Later Dec 1, 2022 24:03


    Papers discussed in today's episode:Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive SleepinessContinuous Positive Airway Pressure and Cardiovascular Risk Reduction in Patients without Excessive Sleepiness: Importance of the Pulse Rate Response

    High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial

    Play Episode Listen Later Nov 24, 2022 28:24


    Paper discussed in today's episode:High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial

    Autoimmune Pulmonary Alveolar Proteinosis

    Play Episode Listen Later Sep 1, 2022 21:47


    Article discussed in this episode:Autoimmune Pulmonary Alveolar Proteinosis

    Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis

    Play Episode Listen Later Aug 18, 2022 27:31


    Article discussed in this episode:Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis

    Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

    Play Episode Listen Later Aug 11, 2022 25:55


    Article discussed in this episode:Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

    A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea

    Play Episode Listen Later Jun 9, 2022 23:58


    Articles discussed in this episode:“A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea"“Drug Therapy for Obstructive Sleep Apnea: Are We There Yet?”

    Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions

    Play Episode Listen Later Apr 21, 2022 18:01


    Article discussed in this episode:Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions 

    Effect of Weight Loss and CPAP on OSA and Metabolic Profile Stratified by Craniofacial Phenotype

    Play Episode Listen Later Mar 17, 2022 20:41


    Article discussed in this episode:Effect of Weight Loss and CPAP on OSA and Metabolic Profile Stratified by Craniofacial Phenotype: A Randomized Clinical Trial

    Using Isoniazid More Safely and More Effectively in Tuberculosis Treatment

    Play Episode Listen Later Feb 22, 2022 35:16


    Articles discussed in today's episode:A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis TreatmentA Semimechanistic Model of the Bactericidal Activity of High-Dose Isoniazid against Multidrug-Resistant Tuberculosis: Results from a Randomized Clinical TrialUsing Isoniazid More Safely and More Effectively: The Time Is Now [Editorial][Note: The episode was updated on February 24, 2022, to fix an audio editing error.]

    Multi-night Prevalence, Variability, and Diagnostic Misclassification of Obstructive Sleep Apnea

    Play Episode Listen Later Jan 20, 2022 21:27


    Article discussed in today's episode:Multi-night Prevalence, Variability, and Diagnostic Misclassification of Obstructive Sleep Apnea 

    Alpha-1 Antitrypsin MZ Heterozygosity is an Endotype of COPD

    Play Episode Listen Later Dec 23, 2021 12:53


    Article discussed in today's episode: Alpha-1 Antitrypsin MZ Heterozygosity is an Endotype of Chronic Obstructive Pulmonary Disease

    Latent Class Analysis in COVID-19

    Play Episode Listen Later Dec 9, 2021 41:22


    Article discussed in today's episode:Latent Class Analysis Reveals COVID-19–related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids

    Effect of Esophageal Pressure-Guided Positive End-Expiratory Pressure on Survival from ARDS

    Play Episode Listen Later Oct 28, 2021 18:23


    Article discussed in today's episode:Effect of Esophageal Pressure-Guided Positive End-Expiratory Pressure on Survival from Acute Respiratory Distress Syndrome: A Risk-Based and Mechanistic Reanalysis of the EPVent-2 Trial

    Association Between PAP Device Manufacturer and Incident Cancer?: A Secondary Data Analysis

    Play Episode Listen Later Oct 14, 2021 21:48


    Paper discussed in today's episode:An Association Between Positive Airway Pressure (PAP) Device Manufacturer and Incident Cancer?: A Secondary Data Analysis

    Association between Troponin I Levels during Sepsis and Postsepsis Cardiovascular Complications

    Play Episode Listen Later Sep 30, 2021 18:50


    Article discussed in today's episode:Association between Troponin I Levels during Sepsis and Postsepsis Cardiovascular Complications

    Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury

    Play Episode Listen Later Sep 16, 2021 27:36


    Article discussed in today's episode: Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury

    Effect of Continuous Positive Airway Pressure on Arrhythmia in Atrial Fibrillation and Sleep Apnea

    Play Episode Listen Later Aug 26, 2021 17:32


    Article discussed in today's episode:Effect of Continuous Positive Airway Pressure on Arrhythmia in Atrial Fibrillation and Sleep Apnea: A Randomized Controlled Trial

    sleep apnea atrial fibrillation arrhythmia continuous positive airway pressure
    Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain

    Play Episode Listen Later Aug 5, 2021 26:21


    Article discussed in today's episode:Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain

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