Podcasts about clinical implications

Featuring perspectives from Dr Daniel George, Dr Leonard G Gomella and Dr Evan Y Yu, moderated by Dr George, including the following topics: Introduction (0:00) Current Treatment Landscape for Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) — Dr Gomella (3:42) Clinical Implications of and Appropriate Strategies to Identify PTEN Deficiency in Prostate Cancer — Dr Yu (35:37) Emerging Role of AKT Inhibition for mHSPC — Dr George (1:06:18) CME information and select publications

In this episode of PT Snacks Podcast, we discuss the significance of understanding osteoporosis medications for physical therapists and PT students. The episode covers the basics of osteoporosis, various medications used in its treatment, and the clinical implications for physical therapy practice. Emphasis is placed on the importance of exercise, fall prevention, and patient education in managing osteoporosis. Additionally, the episode provides guidance on screening for side effects and tailoring exercise programs to individual patient needs.00:00 Introduction to PT Snacks Podcast00:19 Understanding Osteoporosis02:28 Common Osteoporosis Medications05:50 Clinical Implications for Physical Therapists08:08 Patient Education and Medication Adherence09:14 Conclusion and Additional ResourcesSupport the showWhy PT Snacks Podcast?This podcast is your go-to for bite-sized, practical info designed for busy, overwhelmed Physical Therapists and students who want to build confidence in their foundational knowledge without sacrificing life's other priorities. Stay Connected! Never miss an episode—hit follow now! Got questions? Email me at ptsnackspodcast@gmail.com or leave feedback HERE. Join the email list HERE On Instagram? Find unique content at @dr.kasey.hankins! Need CEUs Fast?Time and resources short? Medbridge has you covered: Get over $100 off a subscription with code PTSNACKSPODCAST: Medbridge Students: Save $75 off a student subscription with code PTSNACKSPODCASTSTUDENT—a full year of unlimited access for less!(These are affiliate links, but I only recommend Medbridge because it's genuinely valuable.) Optimize Your Patient Care with Tindeq Looking for a reliable dynamometer to enhance your clinical measurements? Tindeq ...

Video Version Only on HCPLive! In this episode of Diabetes Dialogue: Technology, Therapeutics, and Real-World Perspectives, hosts Diana Isaacs, PharmD, an endocrine clinical pharmacist, director of Education and Training in Diabetes Technology, and codirector of Endocrine Disorders in Pregnancy at the Cleveland Clinic, and Natalie Bellini, DNP, program director of Diabetes Technology at University Hospitals Diabetes and Metabolic Care Center, discuss the newly published findings from the CATALYST trial, a prospective, observational study establishing the prevalence of hypercortisolism among individuals with difficult-to-control type 2 diabetes (T2D). CATALYST enrolled 1057 adults with T2D and suboptimal glycemic control (HbA1c, 7.5–11.5%) despite treatment with ≥2 glucose-lowering agents. All participants underwent a 1-mg overnight dexamethasone suppression test (DST), and common confounders were excluded. Hypercortisolism—defined as a post-DST cortisol level >1.8 µg/dL—was identified in 23.8% of participants, with even higher rates among those with cardiac disease (33.3%) or on ≥3 antihypertensives (36.6%). Adrenal imaging revealed abnormalities in about one-third of affected individuals. Isaacs and Bellini emphasized how striking it is that such a high proportion of patients met criteria for hypercortisolism, a condition historically considered rare. The trial challenges that perception, revealing that clinical features like persistent hyperglycemia and hypertension—despite optimized therapy—could reflect underlying endocrine dysfunction. They noted that neither A1c nor body mass index (BMI) alone predicted elevated cortisol, although medication intensity and comorbid conditions did. The conversation explored how the recognition of hypercortisolism could alter clinical management. Future studies will assess whether targeted treatments—such as cortisol-lowering pharmacotherapy, including mifepristone (Korlym), or adrenal surgery—can reduce medication burden, improve glycemic control, and lower cardiovascular risk. Isaacs and Bellini pointed out that many patients with hypercortisolism present without the classic phenotype, underscoring the importance of broader screening criteria. Looking ahead, they called for greater awareness among clinicians to consider screening in patients on intensive diabetes and blood pressure regimens who still fail to reach therapeutic goals. Identifying and treating hypercortisolism could open a new pathway to improving outcomes in this population. Relevant disclosures for Isaacs include Eli Lilly and Company, Novo Nordisk, Sanofi, Abbott Diabetes Care, Dexcom, Medtronic, and others. Relevant disclosures for Bellini include Abbott Diabetes Care, MannKind, Provention Bio, and others. Key Episode Timestamps 00:00:01 Catalyst Trial Overview and Introduction 00:01:37 Patient Criteria and Initial Findings 00:04:18 Implications and Next Steps 00:05:23 Adrenal Imaging and Cardiac Disorders 00:07:22 Clinical Implications and Future Research 00:09:13 Demographic Differences and Future Directions

Wir besitzen Meinungsfreiheit, haben frei von der Arbeit oder leben schmerzfrei - Freiheit scheint in jeglicher Hinsicht erstrebenswert. Doch was genau ist Freiheit überhaupt? Sinja und Boris versuchen in dieser Folge "Freiheit" philosophisch greifbar zu machen. Anschließend zeigen sie dir verschiedene Wege auf, mit Achtsamkeit und Meditation Freiheit erfahrbar zu machen.Umfrage: Wie gefällt dir Verstehen, fühlen, glücklich sein? Erzähle es uns ⁠hier⁠. Hintergründe und Studien:Brewer, J. A., Mallik, S., Babuscio, T. A., Nich, C., Johnson, H. E., Deleone, C. M., ... & Rounsaville, B. J. (2011). Mindfulness training for smoking cessation: results from a randomized controlled trial. Drug and alcohol dependence, 119(1-2), 72-80. Link zur StudieSumantry, D., & Stewart, K. E. (2021). Meditation, mindfulness, and attention: A meta-analysis. Mindfulness, 12, 1332-1349. Link zur Studie Cortés Pascual, A., Moyano Muñoz, N., & Quílez Robres, A. (2019). The relationship between executive functions and academic performance in primary education: Review and meta-analysis. Frontiers in psychology, 10, 449759. Link zur Studie Bashir, K., Edstrom, S. B., Barlow, S. J., Gainer, D., & Lewis, J. D. (2025). Loving‐Kindness Meditation: Systematic Review of Neuroimaging Correlates in Long‐Term Practitioners and Clinical Implications. Brain and Behavior, 15(3), e70372. Link zur Studie Almahayni, O., & Hammond, L. (2024). Does the Wim Hof Method have a beneficial impact on physiological and psychological outcomes in healthy and non-healthy participants? A systematic review. Plos one, 19(3), e0286933. Link zur Studie Lutz, A., Greischar, L. L., Rawlings, N. B., Ricard, M., & Davidson, R. J. (2004). Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. Proceedings of the national Academy of Sciences, 101(46), 16369-16373. Link zur Studie Mehr zum Thema WOOP: Hier Relevante philosophische Werke:Martin Buber – Ich und Du (1923), Gütersloher Verlagshaus Emmanuel Levinas – Totalität und Unendlichkeit (1961), Klostermann Verlag Hannah Arendt – Vita activa oder Vom tätigen Leben (1958), Piper Verlag Paul Tillich – Der Mut zum Sein (1952), Evangelisches Verlagswerk / später HarperOne Thich Nhat Hanh – Interbeing: Fourteen Guidelines for Engaged Buddhism (1987), Parallax Press

Hey, #CleanFreaks -- are you ready to uncover what's next in endoscope reprocessing? In this exciting series finale episode of "Safe & Sterile Endoscopes," Dr. Ivan Salgo, Chief Medical Officer & Vice President at ASP, joins us to pull back the curtain on the game-changing technologies reshaping our approach to endoscope sterility! From conquering biofilm challenges to elevating quality standards, this episode is packed with innovations that will transform your approach to scope reprocessing. Whether you're #FightingDirty in decontam or leading from the C-suite, you won't want to miss this glimpse into tomorrow's technology – the future of scope safety starts now! This dynamic 6-part series explores the critical world of endoscope innovation, design, and safety. Each episode will feature insights from industry leaders and clinical experts who are transforming the way we approach scope safety and sterility. From frontline technicians to department leaders, this series will equip your team with powerful strategies to transform your reprocessing workflows! A special thanks to our sponsor, Advanced Sterilization Products (ASP), for making this series possible! Their commitment to education and quality in endoscope care has been instrumental in bringing this series to life. Visit our CE Credit Hub at https://www.beyondcleanmedia.com/ce-credit-hub to access this quiz and over 350 other free CE credits.  #BeyondClean #ASP #Endoscopes #SterileProcessing #ScopeSafety #Podcast

00:00 Introduction and Overview of Caristo Diagnostics09:08 The Technology Behind Carry Heart18:00 Clinical Implications and Risk Assessment27:27 Actionable Steps for Patients30:34 Optimizing Cardiovascular Drug Dosing32:31 AI in Cardiovascular Medicine33:50 Leveraging Historical Data for Risk Prediction36:25 AI's Role in Molecular Pathway Analysis39:03 GLP-1 and Cardiovascular Outcomes41:56 Targeted Therapies in Cardiovascular Treatment42:45 Building Trust in New Technologies49:16 Regulatory Approvals and Future Prospects54:15 Expanding Applications Beyond Cardiology57:16 Looking Ahead: The Future of Caristo Diagnostics 

During SMA's 2023 Annual Scientific Assembly, Donald DiPette, MD, FACP, FAHA, discussed the current unsatisfactory hypertension control rates and the need for a new management and treatment approach, as well as barriers to achieving hypertension control with a particular focus on patient-related barriers. He also detailed the the importance of including the patient as part of the management and treatment “team” and presented approaches to include the patient in their hypertension treatment plan.

Dr. Mohleen Kang chats with Dr. Margaret Salisbury and Dr. Anna Podolanczuk about their articles, "Progressive Early Interstitial Lung Abnormalities in Persons at Risk for Familial Pulmonary Fibrosis: A Prospective Cohort Study" and "Big Things Have Small Beginnings: Clinical Implications of Early Interstitial Lung Disease." 

On Episode 48 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2025 issue of Stroke: “Hypoglycemic Events May Trigger Acute Ischemic Stroke Within 30 Days in Those With Diabetes: A Case-Crossover Study” and “Efficacy and Safety of a Dedicated Device for Cerebral Venous Thrombectomy: A Pilot Randomized Clinical Trial.” She also interviews Drs. Johanna Ospel and Umberto Pensato about their article “Cerebral Infarct Growth: Pathophysiology, Pragmatic Assessment, and Clinical Implications.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250113.68216

Earn .1 ASHA CEU for this episode with Speech Therapy PD: https://www.speechtherapypd.com/course?name=Simply-Thick-IDDSI-and-Compassionate-Clinical-ImplicationsJoin Michelle as she welcomes John Holahan, President of SimplyThick, LLC and co-author of Modern Dysphagia Cookbook, for the final episode of 2024. John shares the story behind SimplyThick, its IDDSI connections, and why these insights matter in pediatric care. With his grace, joy, and dedication to supporting others, this episode is a perfect way to end the year on an inspiring note!

CME credits: 1.50 Valid until: 30-12-2025 Claim your CME credit at https://reachmd.com/programs/cme/clinical-implications-of-current-guidelines-on-first-line-immunotherapy-and-parp-inhibitors-for-tnbc/29827/ Treatment decision-making in breast cancer is complex and incorporates several factors including disease- and patient-related characteristics. The NCCN Clinical Practice Guidelines are regularly updated to provide the most accurate recommendations based on recent scientific evidence and drug approvals. This activity has been designed to review the current NCCN guidelines and the supporting data and explore best practices for selecting therapy based on these recommendations. Explore guideline-based strategies and clinical data to optimize guideline-adherent care for patients with CLL/SLL and MCL.

Summary In this episode, Bart Van Buchem and Tim Beames discuss the complexities of nociplastic pain, a relatively new classification of pain that arises from altered nociception without clear evidence of tissue damage. They explore the implications of this classification for clinical practice, the importance of understanding patient perspectives, and the cultural considerations that influence pain terminology. The conversation highlights the challenges of diagnosing nociplastic pain and emphasizes the need for a broader understanding of pain experiences, including psychological factors. They also touch on the upcoming science session featuring Jo Nijs, which aims to further explore these topics. Takeaways - Nociplastic pain is a significant and ongoing debate. - Understanding pain mechanisms is crucial for effective treatment. - Classification of pain can influence treatment decisions. - Patients often seek acknowledgment for their pain experiences. - Cultural factors play a role in how pain is classified and understood. - Pain experiences are often complex and multifaceted. - A broader perspective on pain is necessary for effective management. - Nociplastic pain challenges traditional pain definitions and classifications. - Psychological factors must be considered in pain management. - Upcoming discussions will provide balanced perspectives on pain classification. Topics nociplastic pain, pain classification, chronic pain, pain management, clinical practice, pain terminology, patient perspectives, cultural considerations, pain complexity, treatment implications Chapters 00:00 Introduction to Nociplastic Pain 05:59 Clinical Implications of Nociplastic Pain 12:05 Patient Perspectives on Pain Terminology 18:00 Complexity of Pain Experiences 23:55 The Future of Pain Management Recorded November 2024 Useful Links Le Pub Website: www.lepubscientifique.com  Become a Le Pub member: https://www.lepubscientifique.com/premium-membership  Contact us: info@lepubscientifique.com Follow us: Twitter: @lepubscientifiq Instagram: @lepubscientifique LinkedIn: @LePubScientifique

In this episode of the Spine & Nerve Podcast, Dr. Brian Joves and Dr. Jason Kung dive into the evolving world of peripheral nerve stimulation (PNS). As the field of pain medicine continues to progress, new studies are offering more insights into advanced therapies for challenging conditions like peripheral neuralgia and chronic pain. This discussion focused on the COMFORT study, which evaluates the efficacy of the Nalu PNS System, and discuss recent data presented at the American Society of Regional Anesthesia and Pain Medicine (ASRA) meeting concerning the SPRINT PNS System. Key Topics Covered: COMFORT Study Insights: The doctors analyze the one-year data from the COMFORT trial, a randomized controlled study assessing the Nalu PNS System combined with conventional treatments versus conventional treatments alone for chronic neuropathic pain. They highlight significant findings, including an 87% responder rate with an average pain reduction of 69% among responders at 12 months. SPRINT PNS System Data: Discussion extends to new data from the SPRINT PNS System, particularly the RESET Clinical Trial, which compares 60-day percutaneous PNS to standard interventional management for chronic low back pain. The trial's primary endpoint results indicate that PNS provided clinically meaningful and statistically superior reductions in pain, as well as improvements in function and quality of life. Clinical Implications and Future Directions: Dr. Joves and Dr. Kung explore the broader implications of these studies for clinical practice, emphasizing the importance of personalized treatment plans and the potential for PNS therapies to offer durable pain relief. They also discuss the evolving landscape of pain management and the need for ongoing research to refine and validate these therapeutic approaches. Resources and Links: https://nalumed.com/clinical-trials/comfort-trial/ https://www.sprtherapeutics.com/2024/11/21/new-sprint-pns-data-for-low-back-shoulder-knee-and-headache-at-23rd-annual-asra-pain-medicine-meeting/ Follow us on LinkedIn: ⁠Jason Kung, MD and Brian Joves, MD⁠ Subscribe to the Spine & Nerve Podcast everywhere podcasts are available Keep striving to provide the best care for your patients and stay informed on the evolving practices in pain management! This podcast is for information and educational purposes only, it is not meant to be medical or career advice. If anything discussed may pertain to you, please seek council with your healthcare provider. The views expressed are those of the individuals expressing them, they may not represent the views of Spine & Nerve.

Featuring articles on pembrolizumab perioperative therapy in breast cancer, reduced dose schedules or fractional doses of pneumococcal conjugate vaccine, and nivolumab plus ipilimumab in colorectal cancer; a review article on degenerative rotator-cuff disorders; a case report of a man with seizures and agitation; a Clinical Implications of Basic Research on boning up on boning up; and Perspectives on the Duffy null phenotype; on sickle cell trait, inequity, and the need for change, on “target trial emulation” for observational studies, and on a good day.

Text Dr. Lenz any feedback or questions The Complex Interplay Between Obesity and Chronic PainIn this episode of the 'Conquering Your Fibromyalgia' podcast, Dr. Michael Lenz delves into the intricate relationship between obesity and chronic pain syndromes, including fibromyalgia, chronic fatigue syndrome, and migraines. He explores how obesity and chronic pain often co-exist, affecting each other in a challenging cycle intertwined with feelings of shame, frustration, and hopelessness. Dr. Lenz discusses various studies and findings that highlight the prevalence of chronic pain among obese individuals, the potential physiological and psychological factors involved, and the implications for patient care. Emphasizing an evidence-based approach, he aims to provide listeners with strategies for managing both conditions, fostering a supportive and hopeful journey towards better health.00:00 Introduction00:33 Understanding Obesity and Chronic Pain01:06 The Emotional Impact of Obesity01:51 Frustration and Exhaustion in Weight Management02:39 Defeat and Resilience03:12 Hope and Self-Compassion03:58 Diving into Obesity and Chronic Pain04:10 Defining Obesity and Chronic Pain08:15 Studies on Obesity and Chronic Pain16:55 Obesity's Impact on Joint Pain and Surgery24:42 Psychological and Lifestyle Factors27:55 Clinical Implications and Conclusion Support the showA Fibromyalgia Starter Pack, which is a great companion to the book Conquering Your Fibromyalgia, is now available. Dr. Michael Lenz practices general pediatrics and internal medicine primary care, seeing patients from infants through adults. In addition, he also will see patients with fibromyalgia and related problems and patients interested in lifestyle medicine and clinical lipidology. To learn more, go to ConquringYourFibromyalgia.com. Remember that while Dr. Lenz is a medical doctor, he is not your doctor. All of your signs and symptoms should be discussed with your own physician. He aims to weave the best of conventional medicine with lifestyle medicine to help people with chronic health conditions live their best lives possible. Dr. Lenz hopes that the podcast, book, blog, and website serve as a trusted resource and starting point on your journey of learning to live better with fibromyalgia and related illnesses.

This is the second episode of a two-part miniseries, "IL-31 Inhibition for Treatment of Prurigo Nodularis" series, supported by an educational grant from Galderma. Hosted by expert dermatologist and neuroscientist Dr. Sarina Elmariah, MD, PhD, MPH, this episode, "IL-31 Mechanism and Clinical Implications for PN", featuring Dr. Shawn Kwatra, discusses the following topics: Mechanism of action for IL-31 inhibitor nemolizumab Clinical safety and efficacy data for nemolizumab for treatment of PN Strategies for prescribing IL-31 inhibitors in clinical practice Pearls for patient selection and addressing treatment challenges

Matthew A. Borgman, M.D. is a Professor of Pediatrics in the Division of Pediatric Critical Care at the University of Texas Southwestern.  Dr. Borgman graduated from Uniformed Services University (USU), he completed Pediatric Residency at Brooke Army Medical Center in 2007, followed by a fellowship in Critical Care at Boston Children's Hospital.  He is a prolific author in pediatric trauma management which has helped redefine the care of injured children. He is also the former national chair of the Pediatric Trauma Society Research Committee and has co-authored the 2022 Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations. Learning Objectives:By the end of this podcast, listeners should be able to:Define pediatric hemorrhagic shock and massive transfusion.Develop a guideline-based clinical approach to managing a child with hemorrhagic shock.Explore an expert's approach to managing a child with hemorrhagic shock where the evidence might not be clear. References:Russell et al. Pediatric traumatic hemorrhagic shock consensus conference recommendations. J Trauma Acute Care Surg. 2023 Jan 1;94(1S Suppl 1):S2-S10. Spinella et al. Transfusion Ratios and Deficits in Injured Children With Life-Threatening Bleeding. Pediatr Crit Care Med. 2022 Apr 1;23(4):235-244. Gaines et al. Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion. Ann Surg. 2023 Apr 1;277(4):e919-e924. Moore et al. Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications. Anesth Analg. 2019 Sep;129(3):762-773.Roberts et al. The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess. 2013 Mar;17(10):1-79. Dewan et al. CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial. Trials. 2012 Jun 21;13:87.Spinella et al. Survey of transfusion policies at US and Canadian children's hospitals in 2008 and 2009. Transfusion. 2010 Nov;50(11):2328-35.Whitton TP, Healy WJ. Clinical Use and Interpretation of Thromboelastography. ATS Sch. 2023 Jan 9;4(1):96-97. MATIC-2: Questions, comments or feedback? Please send us a message at this link (leave email address if you would like us to relpy) Thanks! -Alice & ZacSupport the showHow to support PedsCrit:Please complete our Listener Feedback SurveyPlease rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show. Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.

In this episode, Dr. Valentin Fuster reviews a recent study exploring the clinical overlap between heart failure with preserved ejection fraction (HFpEF) and Group 1 pulmonary hypertension. The study identifies a subset of patients with pulmonary hypertension who have a higher risk of heart failure and worse outcomes, emphasizing the need for further investigation into whether pulmonary hypertension therapies could improve prognosis in these patients.

Learn more about structural archetypes from Bill from his FREE courses at http://UHP.network TakeawaysPeople often confuse wide and narrow ISA types due to lack of exposure.Intervening based on best estimates can lead to learning.Measurement should focus on behavior rather than angles.Structural differences influence athletic performance and movement strategies.Identifying ISA types can guide treatment and training approaches.Visual representations can clarify differences between ISA types.Chapters00:00 Understanding Wides and Narrows06:48 Behavioral Responses in Wides and Narrows11:37 Physical Characteristics and Athletic Tendencies17:27 Understanding Diaphragm and Breathing Mechanics20:47 Wide vs Narrow ISA: Structural Differences23:44 Postural Tendencies in Wide and Narrow ISAs26:26 Movement Strategies: Wide vs Narrow ISAs28:53 Clinical Implications of ISA Differences31:25 Real-Life Examples: Bruce Lee and Chuck Norris35:36 Reverse Engineering Movement Patterns38:31 Understanding Compression and Expansion in ISAsLEARN MOREJOIN the UHP Network to learn directly from Bill through articles, videos and courses.http://UHP.network FOLLOW Bill on IG to stay up to date on when his courses are coming out:IG: https://www.instagram.com/bill_hartman_pt/TRAIN WITH BILLInterested in the only training program based on Bill Hartman's Model?Join the rapidly growing community who are reconstructing their bodies at https://www.reconu.co FREE EBOOK by Bill about the guiding principles of training when you fill out your sign-up form. http://www.reconu.co SUBSCRIBE for even more helpful content:YT: https://www.youtube.com/@BillHartmanPTIG: https://www.instagram.com/bill_hartman_pt/FB: https://www.facebook.com/BillHartmanPTWEB: https://billhartmanpt.com/Podcast audio:https://open.spotify.com/show/7cJM6v5S38RLroac6BQjrd?si=eca3b211dafc4202https://podcasts.apple.com/us/podcast/reconsider-with-bill-hartman/id1662268221or download with YT PremiumReconsider… is sponsored by Substance Nutritionhttps://substancenutrition.com/A healthy brain requires a healthy body. Why not take care of both all at once by using Synthesis protein and Neuro Coffee? Use code RECON at checkout to get free shipping on all of your orders

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/CC information, and to apply for credit, please visit us at PeerView.com/AYT865. CME/MOC/CC credit will be available until November 9, 2025.Uncovering the Role of Epithelial Cytokines in CRSwNP: Examining the Clinical Implications of New Approaches with Targeted Biologic Therapy In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AstraZeneca LP.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/CC information, and to apply for credit, please visit us at PeerView.com/AYT865. CME/MOC/CC credit will be available until November 9, 2025.Uncovering the Role of Epithelial Cytokines in CRSwNP: Examining the Clinical Implications of New Approaches with Targeted Biologic Therapy In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AstraZeneca LP.Disclosure information is available at the beginning of the video presentation.

Was man teilweise über Vitamin D hört, klingt fast zu schön, um wahr zu sein. Andererseits deuten hunderte verschiedener Forschungsarbeiten darauf hin, dass Vitamin D zur Vorbeugung einer Reihe von Krankheiten beitragen kann – darunter Osteoporose, Depression, Autoimmun- und Herz-Kreislauf-Erkrankungen. Ärzte empfehlen es. Gesundheits- und Fitnesspodcaster sprechen darüber. Vielleicht geht Dir sogar Deine Lieblingstante damit auf die Nerven. Bei all dem Hype ist die Frage berechtigt: "Solltest Du Vitamin D einnehmen?" Hier sind die Antworten – und die neuesten Fakten über ein faszinierendes Vitamin, das ein wahrer Verwandlungskünstler ist. ____________ *WERBUNG: KoRoDrogerie.de: 5% Ermäßigung auf alles mit dem Code „FMM“ beim Checkout. ____________ Ressourcen zur Folge: Literatur: Ratgeber Nahrungsergänzung – Mark Maslow (kostenlos auf MarathonFitness) Blut: Die Geheimnisse unseres flüssigen Organs* – Ulrich Strunz (Heyne) Vitamin D* – Uwe Gröber, Michael F. Holick (Wissenschaftl. Verlagsgesellschaft) Blutuntersuchung (Selbsttest): Vitamin D Test* von Medivere Präparate: D-Form 2.000 K2+* von FormMed D-Form 2.000 K2+ vegan* von FormMed ____________

Heteroresistance is a phenomenon that has been well characterized for many years. However, we are only now starting to understand its mechanistic basis. Indeed, the manner how bacteria respond to antibiotics is complex and phenomena such as persistance, tolerance may be overlapping with heteroresistance. Furthermore, heteroresistance seems to be common in real clinical scenarios and understanding its basis is likely to open new avenues on how we deploy antibacterials in clinical practice., Today, we have experts in the field to discuss this important topic. Watch this episode at https://youtu.be/qcIcyn1bIHU. Topics discussed: The differences between heteroresistance, persistence and tolerance The mechanistic basis both in Gram-positive and Gram-negative bacteria The clinical implication and diagnosis of heteroresistance Guests: David Weiss, Ph.D. Professor of Medicine and Director Center for Antimicrobial Resistance, Emory University School Of Medicine, Atlanta. GA. William Miller, MD. Assistant Professor of Medicine, Houston Methodist, Houston, TX and Weill Cornell Medical College, New York, NY. Links: Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in Pseudomonas aeruginosa of clinical origin This episode is brought to you by the Antimicrobial Agents and Chemotherapy journal.  Visit asm.org/aac to browse issues and/or submit a manuscript. If you plan to publish in AAC, ASM Members get up to 50% off publishing fees. Visit asm.org/joinasm to sign up. Follow Cesar on twitter at https://twitter.com/SuperBugDoc for AAC updates.  Subscribe to the podcast at https://asm.org/eic.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on papillary muscle delayed hyperenhancement prevalence and clinical implications in a large population with dilated cardiomyopathy.

Link to Buck's Results: https://drive.google.com/file/d/19BJaZNYwBxlPx4nR9695Q2NC3nNpgW6y/view?usp=sharing  https://drive.google.com/file/d/1br1ikAJKmgKev9X3jkS7nUPdXpAqMzYd/view?usp=sharing Section 1: Overview of Cholesterol Metabolism Cholesterol in the Body: Cholesterol is essential for cell membrane integrity, hormone synthesis, and bile acid production. It is produced endogenously in the liver and absorbed exogenously from dietary sources. Endogenous Production: Cholesterol is synthesized in the liver through the mevalonate pathway. Key intermediates: Lathosterol and Desmosterol, indicators of cholesterol production rate. Exogenous Absorption: Dietary cholesterol is absorbed in the intestines along with plant sterols like Beta-sitosterol and Campesterol. These sterols compete with cholesterol for absorption, reflecting dietary cholesterol absorption levels. Section 2: Detailed Analysis of the Test Components Production Markers: Lathosterol: Precursor in the cholesterol biosynthesis pathway. Elevated levels indicate increased hepatic cholesterol synthesis (overproduction). Example: Lathosterol level of 329 µmol x 100/mmol in my study indicates hyperactive cholesterol production. Desmosterol: Another precursor in the synthesis pathway, contributing to total cholesterol production. High levels reinforce the diagnosis of increased cholesterol production. Example: Desmosterol level of 74 µmol x 100/mmol in my study supports elevated production. Absorption Markers: Beta-sitosterol: Plant sterol absorbed in the intestines, competes with cholesterol. High levels suggest increased absorption of dietary cholesterol. Example: Beta-sitosterol level of 120 µmol x 100/mmol indicates borderline absorption. Campesterol: Similar to Beta-sitosterol, reflects cholesterol absorption efficiency. Elevated levels indicate increased absorption. Example: Campesterol level of 113 µmol x 100/mmol within normal limits but suggests absorption could be a factor. Cholesterol Balance Score: Ratio of production to absorption markers. A higher score indicates predominant cholesterol production; a lower score indicates absorption as the main issue. Example: Score of 2.4 suggests overproduction is the dominant issue. Section 3: Clinical Implications and Treatment Strategies (10 minutes) Frequency of Overproduction vs. Overabsorption: Common to see patients with either overproduction or overabsorption, but less commonly both. Overproducers: Significant portion of hypercholesterolemia patients, especially those with genetic conditions like Familial Hypercholesterolemia. Overabsorbers: Often have high-cholesterol diets or genetic predispositions. Treatment Implications: Overproducers: Statins are first-line treatment; they inhibit HMG-CoA reductase in cholesterol synthesis. Overabsorbers: Ezetimibe, which inhibits intestinal cholesterol absorption, can be effective. Combination Therapy: Considered for mixed dyslipidemia cases. Case Examples: Example of a patient with high production markers but borderline absorption: Statin therapy may be appropriate, with potential addition of Ezetimibe. Example of a patient who is a high absorber but not a high producer: Dietary changes and Ezetimibe might suffice without statins. Section 4: Physiological Mechanisms and Genetic Considerations Pathophysiology of Cholesterol Production: Overproduction may result from genetic mutations (LDL receptor or PCSK9) or conditions like insulin resistance. Pathophysiology of Cholesterol Absorption: Increased absorption could be due to genetic polymorphisms (NPC1L1 gene), leading to higher dietary cholesterol absorption. Section 5: Practical Application in Clinical Practice Incorporating the Test into Clinical Workflow: Integrate the Boston Heart Cholesterol Balance Test for patients with unexplained hypercholesterolemia or non-responders to standard therapy. Tailor treatment based on whether a patient is an overproducer, an overabsorber, or both. Patient Communication: Explain test results in an understandable way, emphasizing personalized treatment plans.

Podcast Show Note Summary: Episode Title: "New Guidelines for Corticosteroid Injections in Chronic Pain Management" This podcast is a discussion about the recent review article Use of corticosteroids for adult chronic pain interventions: sympathetic and peripheral nerve blocks, trigger point injections - guidelines from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, the American Society of Interventional Pain Physicians, the International Pain and Spine Intervention Society, and the North American Spine Society In this episode, we dive into the recently published guidelines on the use of corticosteroid injections for managing chronic pain, developed by the American Society of Regional Anesthesia and Pain Medicine, along with several other prominent pain societies. These guidelines address the safety and efficacy of corticosteroid injections for sympathetic and peripheral nerve blocks, as well as trigger point injections. Key Discussion Points: Background and Need for Guidelines: Overview of potential adverse events from corticosteroid injections, such as increased blood glucose levels, decreased bone mineral density, and suppression of the hypothalamic–pituitary axis. Importance of using lower doses of corticosteroids, which studies have found to be just as effective as higher doses. Development of the Guidelines: The guidelines were approved by multiple pain societies and structured into three categories: sympathetic and peripheral nerve blocks, joint injections, and neuraxial injections. Extensive literature review and consensus-building through a modified Delphi process. Key Recommendations: The addition of corticosteroids to local anesthetics is recommended for certain nerve blocks, such as the greater occipital nerve block for cluster headaches and ilioinguinal/iliohypogastric nerve blocks for post-herniorrhaphy pain. Corticosteroid addition is not recommended for sympathetic nerve blocks, greater occipital nerve blocks for migraines, and pudendal nerve blocks for pudendal neuralgia. Imaging guidance (ultrasound or fluoroscopy) improves the safety and accuracy of certain procedures. Efficacy and Safety: Detailed analysis of various studies on the effectiveness of corticosteroid injections for different types of chronic pain. Discussion on the minimal benefit of corticosteroids in trigger point injections and the potential risks associated with their use. Clinical Implications: https://form.jotform.com/240446610837052How these guidelines can assist clinicians in making informed decisions regarding corticosteroid use in chronic pain management. Emphasis on the need for personalized treatment plans based on individual patient characteristics and clinical data. Future Directions: Identification of gaps in the current research and the need for well-designed studies to further assess the benefits and risks of corticosteroid injections. Join us as we explore these comprehensive guidelines and their potential impact on improving chronic pain management practices. Resources: Link to the full guidelines: Journal Online Other Announcements from NRAP Academy: PainExam App is ready for iphone    Pain Management Board Prep migrated to NRAPpain.org AnesthesiaExam Board Prep migrated to NRAPpain.org PMRExam Board Prep migrated to NRAPpain.org   Live Workshop Calendar       Ultrasound Interventional Pain Course Registration    For Anesthesia Board Prep Click Here! References  https://rapm.bmj.com/content/rapm/early/2024/07/16/rapm-2024-105593.full.pdf Disclaimer Disclaimer: This Podcast, website and any content from NRAP Academy (NRAPpain.org) otherwise known as Qbazaar.com, LLC is  for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. Professionals should conduct their own fact finding, research, and due diligence to come to their own conclusions for treating patients. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

Audio Commentary by Dr. Valentin Fuster, Emeritus Editor in Chief

As part of the 2024 Developmental Disabilities Conference, Elizabeth Vosseller and Ian Nordling demonstrate techniques for helping autistic people who cannot use speech reliably to communicate. They discuss the neuroscience behind techniques for helping people with sensory and movement differences to use spelling and typing to communicate. Ian Nordling, a nonspeaking autistic man, provides insights into the lived experience of learning to communicate. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 39751]

As part of the 2024 Developmental Disabilities Conference, Elizabeth Vosseller and Ian Nordling demonstrate techniques for helping autistic people who cannot use speech reliably to communicate. They discuss the neuroscience behind techniques for helping people with sensory and movement differences to use spelling and typing to communicate. Ian Nordling, a nonspeaking autistic man, provides insights into the lived experience of learning to communicate. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 39751]

As part of the 2024 Developmental Disabilities Conference, Elizabeth Vosseller and Ian Nordling demonstrate techniques for helping autistic people who cannot use speech reliably to communicate. They discuss the neuroscience behind techniques for helping people with sensory and movement differences to use spelling and typing to communicate. Ian Nordling, a nonspeaking autistic man, provides insights into the lived experience of learning to communicate. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 39751]

As part of the 2024 Developmental Disabilities Conference, Elizabeth Vosseller and Ian Nordling demonstrate techniques for helping autistic people who cannot use speech reliably to communicate. They discuss the neuroscience behind techniques for helping people with sensory and movement differences to use spelling and typing to communicate. Ian Nordling, a nonspeaking autistic man, provides insights into the lived experience of learning to communicate. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 39751]

Welcome to PICU Doc On Call, where Dr. Pradip Kamat from Children's Healthcare of Atlanta/Emory University School of Medicine and Dr. Rahul Damania from Cleveland Clinic Children's Hospital delve into the intricacies of Pediatric Intensive Care Medicine. In this special episode of PICU Doc on Call shorts, we dissect the Alveolar Gas Equation—a fundamental concept in respiratory physiology with significant clinical relevance.Key Concepts Covered:Alveolar Gas Equation Demystified: Dr. Rahul explains the Alveolar Gas Equation, which calculates the partial pressure of oxygen in the alveoli (PAO2). This equation, PAO2 = FiO2 (Patm - PH2O) - (PaCO2/R), is essential in understanding hypoxemia and the dynamics of gas exchange in the lungs.Calculating PAO2: Using the Alveolar Gas Equation, the hosts demonstrate how to calculate PAO2 at sea level, emphasizing the influence of atmospheric pressure, fraction of inspired oxygen (FiO2), water vapor pressure, arterial carbon dioxide pressure (PaCO2), and respiratory quotient (R) on oxygenation.A-a Gradient and Hypoxemia: The A-a gradient, derived from the Alveolar Gas Equation, is discussed in the context of hypoxemia evaluation. Understanding the causes of hypoxemia, including ventilation/perfusion (V/Q) mismatch, anatomical shunt, diffusion defects, and hypoventilation, is crucial for clinical diagnosis and management.Clinical Scenarios and A-a Gradient Interpretation: Through a clinical scenario, the hosts elucidate how different conditions affect the A-a gradient and oxygenation, providing insights into respiratory pathophysiology and differential diagnosis.Clinical Implications and Management Strategies: The hosts highlight the clinical significance of the Alveolar Gas Equation in assessing oxygenation status, diagnosing gas exchange abnormalities, and tailoring respiratory management strategies in the pediatric intensive care setting.Key Takeaways:Utility of the Alveolar Gas Equation: Understanding and applying the Alveolar Gas Equation is essential for evaluating oxygenation and diagnosing respiratory abnormalities.Interpreting A-a Gradient: A normal A-a gradient suggests alveolar hypoventilation as the likely cause of hypoxemia, whereas elevated gradients indicate other underlying pathologies.Clinical Relevance: Recognizing the clinical implications of the Alveolar Gas Equation aids in accurate diagnosis and optimal management of respiratory conditions in pediatric intensive care patients.Conclusion:Join Dr. Kamat and Dr. Damania as they unravel the complexities of the Alveolar Gas Equation, providing valuable insights into respiratory physiology and its clinical applications. Don't forget to subscribe, share your feedback, and visit picudoconcall.org for more educational content and resources.References:Fuhrman & Zimmerman - Textbook of Pediatric Critical Care Chapter: Physiology of the respiratory system. Chapter 42. Khemani et al. Pages 470-481Rogers textbook of Pediatric intensive care: Chapter 44....

In today's episode I talk about facial pain. 1/3 of non-dental facial pain is idiopathic, meaning without a specific cause. During this episode l discuss the 6 major classifications of facial pain along with the psycho social impacts of facial pain sufferers. I round off the episode by discussing what I'm currently doing in clinic with people struggling with facial pain. Do you suffer from facial pain. If so, what has helped you along the way? Comment below! Episode Resources  *(No authors listed). International Classification of Orofacial Pain, 1st edition (ICOP). Cephalalgia. 2020;40(2):129-221. doi:10.1177/0333102419893823. *Ziegeler C, Beikler T, Gosau M & May A. Idiopathic Facial Pain Syndromes - An Overview and Clinical Implications. Dtsch Arztebl Int. 2021;118(6):81-87. doi:10.3238/arztebl.m2021.0006.  --- Send in a voice message: https://podcasters.spotify.com/pod/show/concast/message

In this question-and-answer session, you can join Dr. Justin Elikofer as he answers questions about TMJ and oral appliance therapy.Webinar Description:Does OAT cause TMD?Isn't TMD contraindicated for OAT?The possibility of causing patients pain or complications can seem daunting when considering making a sleep appliance. Dr. Justin Elikofer has delivered thousands of appliances and will share the importance of understanding the OAT/TMJ relationship.This webinar will delve deep into the intricate anatomy of the TMJ, its complex movements, and its vital role in effective OAT.You'll gain a holistic understanding of how these two critical elements interact, leading to more effective treatment strategies and improved patient outcomes.Watch as Dr. Elikofer discusses:Secrets of TMJ's structure and its functional significance in dental sleep medicine.Dynamic movements of the TMJ and their implications in diagnosing and managing sleep disorders.Art of identifying key clinical signs during TMJ examinations and how to apply these insights in optimizing OAT.Strategies for managing TMJ signs and symptoms with OAT.A collaborative approach to treating TMJ disorders alongside sleep apnea.Whether you're new to dental sleep medicine or looking to refine your skills, this session will provide valuable insights and practical tools to enhance your practice.By this webinar's end, you'll learn:Enhanced understanding of TMJ anatomy and its clinical relevance in OAT.Practical skills in assessing TMJ movement and its implications in treatment.Insights into the effective integration of OAT in managing TMJ disorders.Strategies to co-manage TMD alongside sleep apnea with OAT.Confidence in applying a holistic approach to dental sleep medicine.Watch now to transform how you treat TMJ and OAT in your dental sleep medicine practice.Meet the Speaker!Dr. Justin ElikoferDr. Elikofer excelled in academic studies and enjoyed 3D ceramic art, which highly impacted his post-secondary medical education - he found that dentistry was the perfect mix of art and medicine. He graduated from the Indiana University School of Dentistry and took a position with a traveling oral surgery team focused on treating hurting teeth. In 2018, Dr. Elikofer moved to South Florida. He practiced Dental Sleep Medicine under the direction of the AADSM and obtained diplomate status in 2020. Before becoming a private practice owner, he explored the best path to effectively treating patients. Seeing how these devices stabilize the airway and ultimately impact patients' lives has shown Dr. Elikofer the power of practicing sleep. In his time off, you can find Dr. Elikofer on the water or beach on a nice day or at a sporting event. He follows the USF Bulls, Buccaneers, Rays, and Lightning.Thank you to our sponsors for making this education possible:Nierman Practice Management, United Credit, Kettenbach Dental, ProSomnus Sleep Technologies, and Sleep Apnea Leads

Webinar Description:Does OAT cause TMD?Isn't TMD contraindicated for OAT?The possibility of causing patients pain or complications can seem daunting when considering making a sleep appliance. Dr. Justin Elikofer has delivered thousands of appliances and will share the importance of understanding the OAT/TMJ relationship.This webinar will delve deep into the intricate anatomy of the TMJ, its complex movements, and its vital role in effective OAT.You'll gain a holistic understanding of how these two critical elements interact, leading to more effective treatment strategies and improved patient outcomes.Watch as Dr. Elikofer discusses:Secrets of TMJ's structure and its functional significance in dental sleep medicine.Dynamic movements of the TMJ and their implications in diagnosing and managing sleep disorders.Art of identifying key clinical signs during TMJ examinations and how to apply these insights in optimizing OAT.Strategies for managing TMJ signs and symptoms with OAT.A collaborative approach to treating TMJ disorders alongside sleep apnea.Whether you're new to dental sleep medicine or looking to refine your skills, this session will provide valuable insights and practical tools to enhance your practice.By this webinar's end, you'll learn:Enhanced understanding of TMJ anatomy and its clinical relevance in OAT.Practical skills in assessing TMJ movement and its implications in treatment.Insights into the effective integration of OAT in managing TMJ disorders.Strategies to co-manage TMD alongside sleep apnea with OAT.Confidence in applying a holistic approach to dental sleep medicine.Watch now to transform how you treat TMJ and OAT in your dental sleep medicine practice.Meet the Speaker!Dr. Justin ElikoferDr. Elikofer excelled in academic studies and enjoyed 3D ceramic art, which highly impacted his post-secondary medical education - he found that dentistry was the perfect mix of art and medicine. He graduated from the Indiana University School of Dentistry and took a position with a traveling oral surgery team focused on treating hurting teeth. In 2018, Dr. Elikofer moved to South Florida. He practiced Dental Sleep Medicine under the direction of the AADSM and obtained diplomate status in 2020. Before becoming a private practice owner, he explored the best path to effectively treating patients. Seeing how these devices stabilize the airway and ultimately impact patients' lives has shown Dr. Elikofer the power of practicing sleep. In his time off, you can find Dr. Elikofer on the water or beach on a nice day or at a sporting event. He follows the USF Bulls, Buccaneers, Rays, and Lightning.Thank you to our sponsors for making this education possible:Nierman Practice Management, United Credit, Kettenbach Dental, ProSomnus Sleep Technologies, and Sleep Apnea Leads

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/NZZ865. CME/MOC/AAPA credit will be available until December 28, 2024.Cracking the Code in COPD: Understanding the Role of Type 2 Inflammation and Potential Clinical Implications of Targeted Treatment In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi.Disclosure PolicyAll relevant conflicts of interest have been mitigated prior to the commencement of the activity.Faculty/Planner DisclosuresChair/PlannerFernando J. Martinez, MD, MS, has a financial interest/relationship or affiliation in the form of:Consultant and/or Advisor for AstraZeneca; GSK; Polarean, Inc.; and Sanofi/Regeneron Pharmaceuticals Inc.Grant/Research Support from AstraZeneca; Chiesi USA, Inc.; GSK; and Sanofi/Regeneron Pharmaceuticals Inc.Speaker for AstraZeneca and GSK.Planning Committee and Reviewer DisclosuresPlanners, independent reviewers, and staff of PVI, PeerView Institute for Medical Education, do not have any relevant financial relationships related to this CE activity unless listed below.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/NZZ865. CME/MOC/AAPA credit will be available until December 28, 2024.Cracking the Code in COPD: Understanding the Role of Type 2 Inflammation and Potential Clinical Implications of Targeted Treatment In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi.Disclosure PolicyAll relevant conflicts of interest have been mitigated prior to the commencement of the activity.Faculty/Planner DisclosuresChair/PlannerFernando J. Martinez, MD, MS, has a financial interest/relationship or affiliation in the form of:Consultant and/or Advisor for AstraZeneca; GSK; Polarean, Inc.; and Sanofi/Regeneron Pharmaceuticals Inc.Grant/Research Support from AstraZeneca; Chiesi USA, Inc.; GSK; and Sanofi/Regeneron Pharmaceuticals Inc.Speaker for AstraZeneca and GSK.Planning Committee and Reviewer DisclosuresPlanners, independent reviewers, and staff of PVI, PeerView Institute for Medical Education, do not have any relevant financial relationships related to this CE activity unless listed below.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/NZZ865. CME/MOC/AAPA credit will be available until December 28, 2024.Cracking the Code in COPD: Understanding the Role of Type 2 Inflammation and Potential Clinical Implications of Targeted Treatment In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi.Disclosure PolicyAll relevant conflicts of interest have been mitigated prior to the commencement of the activity.Faculty/Planner DisclosuresChair/PlannerFernando J. Martinez, MD, MS, has a financial interest/relationship or affiliation in the form of:Consultant and/or Advisor for AstraZeneca; GSK; Polarean, Inc.; and Sanofi/Regeneron Pharmaceuticals Inc.Grant/Research Support from AstraZeneca; Chiesi USA, Inc.; GSK; and Sanofi/Regeneron Pharmaceuticals Inc.Speaker for AstraZeneca and GSK.Planning Committee and Reviewer DisclosuresPlanners, independent reviewers, and staff of PVI, PeerView Institute for Medical Education, do not have any relevant financial relationships related to this CE activity unless listed below.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/NZZ865. CME/MOC/AAPA credit will be available until December 28, 2024.Cracking the Code in COPD: Understanding the Role of Type 2 Inflammation and Potential Clinical Implications of Targeted Treatment In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi.Disclosure PolicyAll relevant conflicts of interest have been mitigated prior to the commencement of the activity.Faculty/Planner DisclosuresChair/PlannerFernando J. Martinez, MD, MS, has a financial interest/relationship or affiliation in the form of:Consultant and/or Advisor for AstraZeneca; GSK; Polarean, Inc.; and Sanofi/Regeneron Pharmaceuticals Inc.Grant/Research Support from AstraZeneca; Chiesi USA, Inc.; GSK; and Sanofi/Regeneron Pharmaceuticals Inc.Speaker for AstraZeneca and GSK.Planning Committee and Reviewer DisclosuresPlanners, independent reviewers, and staff of PVI, PeerView Institute for Medical Education, do not have any relevant financial relationships related to this CE activity unless listed below.

Haemochromatosis explained, including iron physiology and haemochromatosis pathophysiology, as well as the various genetic causes of hereditary haemochromatosis. We also look at the main symptoms, diagnostic tests and treatment options. Consider subscribing on YouTube (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Haemochromatosis? 0:15 Haemochromatosis Pathophysiology 2:24 Hereditary Haemochromatosis Genetics3:53 Causes of Secondary Haemochromatosis4:11 Haemochromatosis Symptoms6:18 Haemochromatosis Diagnosis7:58 Haemochromatosis TreatmentReferencesBMJ Best Practice (2023) Haemochromatosis. Available at https://bestpractice.bmj.com/topics/en-gb/134Hamilton, J - MSD Manual Pro (2022) Hereditary Hemochromatosis. Available at https://www.msdmanuals.com/professional/hematology-and-oncology/iron-overload/hereditary-hemochromatosisHamilton, J. - MSD Manual Pro (2022) Overview of Iron Overload. Available at https://www.msdmanuals.com/professional/hematology-and-oncology/iron-overload/overview-of-iron-overloadHamilton, J - MSD Manual Pro (2022) Secondary Iron Overload. Available at https://www.msdmanuals.com/professional/hematology-and-oncology/iron-overload/secondary-iron-overloadBritish Society for Haematology (2021) Guidelines for the monitoring and management of iron overload in patients with haemoglobinopathies and rare anaemias. Available at https://b-s-h.org.uk/guidelines/guidelines/guidelines-for-the-monitoring-and-management-of-iron-overload-in-patients-with-haemoglobinopathies-and-rare-anaemiasTsutomu N. (2017) Diagnosis and Clinical Implications of Diabetes in Liver Cirrhosis: A Focus on the Oral Glucose Tolerance Test. Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686620/Please remember this podcast and all content from Rhesus Medicine is meant for educational purposes only and should not be used as a guide to diagnose or to treat. Please consult a healthcare professional for medical advice. 

Are you up to date on the latest clinical trial and real-world data in breast cancer and how this impacts individualization of care? Credit available for this activity expires: 1/16/25 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/999668?ecd=bdc_podcast_libsyn_mscpedu

We are excited to bring you a fantastic episode today where we are joined by two guest experts to discuss the recent JAMA Surgery manuscript, “Clinical Implications of Removing Race-Corrected Pulmonary Function Tests for African American Patients Requiring Surgery for … Continue reading →

Please visit answersincme.com/ZRV860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, two experts in lung carcinoma discuss the latest data in first-line chemoimmunotherapy for non–small-cell lung cancer.Upon completion of this activity, participants should be better able to: Outline which patients might align with first-line chemoimmunotherapy regimens for advanced NSCLC; Review the clinical profiles of chemoimmunotherapy regimens in the first-line setting for the treatment of advanced NSCLC; and Translate the latest data informing the use of first-line chemoimmunotherapy regimens to individualized care of patients with advanced NSCLC.

In this episode of the School of Doza podcast, Nurse Doza discusses the importance of taking control of your health and provides valuable information on five blood tests you should be getting each year. With his passion for helping others, Nurse Doza aims to empower his listeners to optimize their health and make informed decisions. Don't forget to check out the Nurse Doza YouTube channel for video content and subscribe to the newsletter for bi-weekly updates.    TIMESTAMPS: 00:00 START 02:11 HSCRP: Marker of Inflammation. 04:28 Inflammatory diseases like autoimmune issues. 07:09 Fasting insulin and inflammation. 10:37 Athletes and their diet. 14:45 Problems with insulin and longevity. 19:23 Your body's response to stress. 23:49 Low DHS and mortality. 26:05 Chronic autoimmune disorders and infections. 28:06 Homocysteine and its implications. 31:08 High homocysteine and its impact.   Are you looking to optimize your health and wellness even further? Meet Bliss, a scientifically-formulated supplement designed to fill the gaps in your diet and complement your daily health routine. Take a proactive step with Bliss, and feel the difference it can make. Click the link to order your Bliss supplement now and start your journey towards enhanced well-being https://www.mswnutrition.com/products/bliss   SHOW NOTES FIRST: High-Sensitivity C-Reactive Protein (hs-CRP) High-sensitivity C-reactive protein (hs-CRP) is a critical marker of inflammation. This biomarker can predict the likelihood of myocardial infarction, stroke, peripheral arterial disease, and sudden cardiac death in healthy individuals with no prior history of cardiovascular disease. In addition, hs-CRP can also predict recurrent events and death in patients with acute or stable coronary syndromes[^1^]. Studies have shown that hs-CRP levels were significantly higher in patients with depression than in control subjects, indicating low-grade inflammation[^2^]. Furthermore, CRP, the protein that hs-CRP measures, binds phosphocholine (PC) with high affinity in the presence of calcium (Ca++)[^3^].  Studies:  [^1^]: High-sensitivity C-reactive protein: clinical importance [https://pubmed.ncbi.nlm.nih.gov/15258556/] [^2^]: Elevated C-Reactive Protein in Patients With Depression, Independent of Genetic, Health, and Psychosocial Factors: Results From the UK Biobank [https://pubmed.ncbi.nlm.nih.gov/33985349/] [^3^]: C-Reactive Protein (CRP) and Autoimmune Disease: Facts and Conjectures [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486333/] [^4^]: Therapeutic Lowering of C-Reactive Protein [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901964/] SECOND: Fasting Insulin Fasting insulin is a critical test for detecting insulin resistance, which is associated with an exacerbated risk of hypertension in the general population[^2^]. Elevated fasting insulin concentrations can result from factors like neuroinflammation, oxidative stress from mitochondrial dysfunction, or dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis[^5^]. Additionally, leptin, another hormone related to insulin, has been found to correlate with various health conditions like cardiovascular disease, hypertension, stroke, dyslipidemia[^5^]. Studies: [^2^]: Fasting insulin, insulin resistance and risk of hypertension in the general population: A meta-analysis [https://pubmed.ncbi.nlm.nih.gov/27836689/] [^3^]: Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419605/] [^4^]: Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity [https://pubmed.ncbi.nlm.nih.gov/18253163/] [^5^]: Peripheral versus central insulin and leptin resistance: Role in metabolic disorders, cognition, and neuropsychiatric diseases [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642294/] [^6^]: Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774814/] THIRD: DHEA-S (Dehydroepiandrosterone Sulfate) DHEA and its sulfated metabolite DHEA-S are endogenous hormones secreted by the adrenal cortex. These hormones are essential for the production of sex hormones, including androgens (testosterone and androstenedione) and estrogen[^1^]. Studies have shown that low DHEA-S levels have been associated with all-cause mortality, cardiovascular, and inflammatory diseases[^3 ^]. Furthermore, a recent systematic review and meta-analysis have pointed out that DHEA could serve as a valuable biomarker for stress[^14^]. Studies: [^1^]: DHEA and DHEA-S: a review [https://pubmed.ncbi.nlm.nih.gov/10197292/] [^2^]: Dehydroepiandrosterone [https://www.mountsinai.org/health-library/supplement/dehydroepiandrosterone] [^3^]: Very High Dehydroepiandrosterone Sulfate (DHEAS) in Serum of an Overweight Female Adolescent Without a Tumor [https://www.frontiersin.org/articles/10.3389/fendo.2020.00240/full] [^4^]: Low serum DHEA-S is associated with impaired lung function in women [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280766/] [^14^]: DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis [https://www.frontiersin.org/articles/10.3389/fpsyt.2021.688367/full] FOURTH: Vitamin D Vitamin D is a group of fat-soluble secosteroids that play a vital role in calcium homeostasis and bone health. Vitamin D insufficiency has been linked to various health problems, including cardiovascular disease, certain cancers, cognitive decline, and severe infections such as COVID-19[^7^]. There's also evidence suggesting that vitamin D can modulate the immune system and has anti-inflammatory properties[^8^]. Studies: [^7^]: Vitamin D and Cardiovascular Disease [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132695/] [^8^]: A Review of the Critical Role of Vitamin D in the Functioning of the Immune System and the Clinical Implications of Vitamin D Deficiency [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/] [^9^]: Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws [https://www.ncbi.nlm.nih.gov/pubmed/24603370/] [^10^]: Effect of Vitamin D Supplementation on the Incidence of Gestational Diabetes [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438452/] FIFTH: Omega-3 Index Omega-3 Index, expressed as a percentage, measures the amount of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) in red blood cell membranes. It's considered a reflection of a person's omega-3 fatty acid status and has been correlated with various health outcomes. High levels of omega-3s are associated with a lower risk of death from heart disease[^11^]. In addition to cardiovascular benefits, omega-3 fatty acids also have anti-inflammatory properties and are crucial for brain health[^12^]. Studies: [^11^]: Omega-3 Index and Sudden Cardiac Death [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664414/] [^12^]: Omega-3 Fatty Acids and Inflammation [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257651/] [^13^]: Omega-3 fatty acids and mood disorders [https://www.ncbi.nlm.nih.gov/pubmed/18640689/] [^15^]: Fish consumption, omega-3 fatty acids and risk of heart failure: A meta-analysis [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499005/]

Contributor: Aaron Lessen, MD Educational Pearls: What is Tranq? Tranq is the street name for xylazine, a sedative drug typically used in veterinary medicine. Xylazine has recently emerged as a recreational drug, often mixed with heroin or fentanyl.  The mechanism of action of xylazine is similar to dexmedetomidine (Precedex), an alpha-2 adrenergic receptor agonist. At toxic levels, either by itself or when combined with opioids, can cause apnea, bradycardia, coma, and hypotension. How is it different from other adulterants, such as fentanyl? Because It is not an opioid, naloxone (Narcan) does not reverse its effects. It may cause local peripheral vasoconstriction leading to necrotic ulcerations at sites of repeated injection. How do you treat a suspected overdose of Tranq +/- an opioid? Consult with a clinical toxicologist. Naloxone should still be used despite its limited effect. At the very least it will not make the situation worse. Be ready to intubate. Provide supportive care. Non-selective alpha antagonists are NOT recommended. References Ruiz-Colón K, Chavez-Arias C, Díaz-Alcalá JE, Martínez MA. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: A comprehensive review of the literature. Forensic Sci Int. 2014 Jul;240:1-8. doi: 10.1016/j.forsciint.2014.03.015. Epub 2014 Mar 26. PMID: 24769343. Ayub S, Parnia S, Poddar K, Bachu AK, Sullivan A, Khan AM, Ahmed S, Jain L. Xylazine in the Opioid Epidemic: A Systematic Review of Case Reports and Clinical Implications. Cureus. 2023 Mar 29;15(3):e36864. doi: 10.7759/cureus.36864. PMID: 37009344; PMCID: PMC10063250. Malayala SV, Papudesi BN, Bobb R, Wimbush A. Xylazine-Induced Skin Ulcers in a Person Who Injects Drugs in Philadelphia, Pennsylvania, USA. Cureus. 2022 Aug 19;14(8):e28160. doi: 10.7759/cureus.28160. PMID: 36148197; PMCID: PMC9482722. United States Drug Enforcement Administration. DEA Reports Widespread Threat of Fentanyl Mixed with Xylazine | DEA.gov. (n.d.). https://www.dea.gov/alert/dea-reports-widespread-threat-fentanyl-mixed-xylazine  Summarized by Jeffrey Olson, MS1 | Edited by Meg Joyce & Jorge Chalit, OMSII

Dr. Alfonso Mercado—a licensed psychologist and Associate Professor at the University of Texas-Rio Grande Valley—discusses the mental health impacts and implications of policies of family separation. 

Featuring perspectives from Drs Andrew J Armstrong and Rana R McKay, including the following topics: Introduction (0:00) Intensification of endocrine therapy: Emerging role in nonmetastatic disease; choice of androgen deprivation therapy (3:31) Management of castration-resistant M0 disease; PROTACs, CDK4/6 inhibitors and other new endocrine approaches (16:18) Hormone-sensitive metastatic disease — Choice of antiandrogen (26:48) Castration-resistant metastatic disease (37:06) Genomic evaluation; PARP inhibitors for metastatic disease (46:24) Ideal sequencing of PARP inhibitors; management of associated side effects (55:21) Biomarker testing; MSI-high disease; TKIs with immunotherapy; bispecific antibodies? (59:42) CME information and select publications

In this episode of the SOD podcast, NURSE DOZA focuses on gut health and how to restore it. He dives into the topic of gut health and explains the essential role that the gut plays in overall health. He discusses how the gut can get messed up and offers practical tips for restoring gut health. The episode concludes with the host urging listeners to prioritize gut health and providing resources for further education.   TIMESTAMPS: 00:00 POD BEGINS 02:34 Fasting for gut restoration. 04:30 The benefits of fasting. 07:24  Leaky Gut Syndrome. 11:56   Healing the digestive tract. 15:50  Gut health and microbiome. 19:11   Antibiotics killing good bacteria. 21:56  Healthy microbiome and probiotics. 25:28  Restoring gut health. 29:11   Gut health and L-glutamine. 33:07  Anti-nutrients in common foods. 37:09 Gut Health and Fermented Foods. 40:36 Gut Health Tips.   This episode is brought to you but Gut by MSW Nutrition: Get 10% by clicking the link https://www.mswnutrition.com/products/gut?ref=NURSEDOZA   REFERENCES: “IF enhances parasympathetic activity (mediated by the neurotransmitter acetylcholine) in the autonomic neurons that innervate the gut, heart, and arteries, resulting in improved gut motility and reduced heart rate and blood pressure.”   “Levels of oxidative stress and inflammation are reduced throughout the body and brain in response to IF.”   “Finally, in addition to its many effects on cells throughout the body and brain, IF may elicit changes in the gut microbiota that protect against MS (Tremaroli and Backhed, 2012).”   “The link between the microbes in the human gut and the development of obesity, cardiovascular disease, and metabolic syndromes, such as type 2 diabetes, is becoming clearer. “(2) Studies: _Fasting: Molecular Mechanisms and Clinical Applications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946160/_(1)_______   Functional interactions between the gut microbiota and host metabolism https://pubmed.ncbi.nlm.nih.gov/22972297/(2)   “Longitudinal studies in patients with IBD suggest that increased intestinal permeability preceded relapsed of Crohn's disease,[55] suggesting a pathogenetic role of the epithelial barrier in the pathogenesis of gut inflammation; in addition, IBS is highly prevalent in first-degree relatives of IBD patients,[56] suggesting that intestinal permeability could be a relevant factor in the determination of symptoms.” (1) Studies: _The Leaky Gut: Mechanisms, Measurement and Clinical Implications in Humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790068/ (1)   Studies: _Microbiome and Gut Dysbiosis https://pubmed.ncbi.nlm.nih.gov/30535609/(1)   Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304917/(2)   Probiotic Species in the Modulation of Gut Microbiota: An Overview https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964481/(3) Studies: A Randomized Placebo-Controlled Trial of Dietary Glutamine Supplements for Post-Infectious Irritable Bowel Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549483/(1)   Glutamine, as a precursor of glutathione, and oxidative stresshttps://pubmed.ncbi.nlm.nih.gov/10356308/(2) Studies: ___Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304917/_(1)_____   Modern perspectives on the health benefits of kefir in next-generation sequencing era: Improvement of the host gut microbiota https://pubmed.ncbi.nlm.nih.gov/29336590/ (2)   The fermented-food diet increases microbiome diversity, decreases inflammatory proteins, study finds https://med.stanford.edu/news/all-news/2021/07/fermented-food-diet-increases-microbiome-diversity-lowers-inflammation(3)   Gut-microbiota-targeted diets modulate human immune status https://www.cell.com/cell/fulltext/S0092-8674(21)00754-6(4)   Avocado Consumption Alters Gastrointestinal Bacteria Abundance and Microbial Metabolite Concentrations among Adults with Overweight or Obesity: A Randomized Controlled Trial https://academic.oup.com/jn/article/151/4/753/5893497(5)   LECTINS: https://www.hsph.harvard.edu/nutritionsource/anti-nutrients/lectins/(6)

A client with hip and back pain is referred to a massage therapist by her chiropractor. But there's a hitch: This person also has arrhythmia and hemochromatosis. Hemochromatosis is one of the most common inherited disorders in White people, and it can lead to life-threatening complications. One of those complications might be a factor in this client's situation. Fortunately, if it's found early, hemochromatosis is highly treatable. Listen to this episode of “I Have a Client Who . . .” for more!   Sponsors:     Books of Discovery: www.booksofdiscovery.com     Massage Mentor Institute: www.themassagementorinstitute.com       Host Bio:                    Ruth Werner is a former massage therapist, a writer, and an NCBTMB-approved continuing education provider. She wrote A Massage Therapist's Guide to Pathology, now in its seventh edition, which is used in massage schools worldwide. Werner is also a long-time Massage & Bodywork columnist, most notably of the Pathology Perspectives column. Werner is also ABMP's partner on Pocket Pathology, a web-based app and quick reference program that puts key information for nearly 200 common pathologies at your fingertips. Werner's books are available at www.booksofdiscovery.com. And more information about her is available at www.ruthwerner.com.                                      Recent Articles by Ruth:          “Working with Invisible Pain,” Massage & Bodywork magazine, November/December 2022, page 36, http://www.massageandbodyworkdigital.com/i/1481961-november-december-2022/38   “Unpacking the Long Haul,” Massage & Bodywork magazine, January/February 2022, page 35, www.massageandbodyworkdigital.com/i/1439667-january-february-2022/36.   “Chemotherapy-Induced Peripheral Neuropathy and Massage Therapy,” Massage & Bodywork magazine, September/October 2021, page 33, http://www.massageandbodyworkdigital.com/i/1402696-september-october-2021/34.           “Pharmacology Basics for Massage Therapists,” Massage & Bodywork magazine, July/August 2021, page 32, www.massageandbodyworkdigital.com/i/1384577-july-august-2021/34.       Resources:    Pocket Pathology: https://www.abmp.com/abmp-pocket-pathology-app   Adams, P.C. (2020) ‘Hemochromatosis: Ancient to the Future', Clinical Liver Disease, 16(Suppl 1), pp. 83–90. Available at: https://doi.org/10.1002/cld.940.   Hemochromatosis (Iron Overload): Causes, Symptoms, Treatment, Diet & More (no date) Cleveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/14971-hemochromatosis-iron-overload (Accessed: 7 February 2023).   ‘Hemochromatosis: Practice Essentials, Background, Pathophysiology' (2023). Available at: https://emedicine.medscape.com/article/177216-overview#a7 (Accessed: 7 February 2023).   ‘Hereditary Hemochromatosis and HFE: Practice Essentials, Clinical Implications of the Genetic Mutation, Testing for the Genetic Mutation' (2022). Available at: https://emedicine.medscape.com/article/1878061-overview (Accessed: 7 February 2023). Sponsors: The Massage Mentor Institute In 2019, Diane Matkowski, aka the Massage Mentor, began a private Facebook page for hosting discussions with industry leaders. These interviews gave her ideas for The Massage Mentor Institute and Jam Series workshops. The goal was to create various continuing education classes offered in one spot. The Institute is a space for massage therapists to learn different approaches and philosophies of bodywork and business classes. It's also home to the Shoulder, Hip, Neck, and Back Jam workshops. We believe that no one technique works for every human being. Our goal is to help you find your path. We have selected teachers we trust, admire, and believe will help you grow as a licensed massage therapist.   Website: themassagementorinstitute.com   Facebook Group: facebook.com/themassagementor   Instagram: @massagementorinstitute  

The field of Cardiovascular Genomics has advanced tremendously over the past two decades, having a significant clinical impact and changing the perception of the role and scope of genetic testing in several cardiovascular domains.  To kickstart the Cardiovascular Genomics series, CardioNerds Dr. Sara Coles (FIT at Duke University), Dr. Colin Blumenthal (CardioNerds Academy faculty and FIT at UPenn), and Dr. Karla Asturias (CardioNerds Academy fellow and medicine resident at Pennsylvania Hospital) have a great discussion with Dr. James Daubert, a clinical electrophysiologist at Duke University, with a particular interest in inherited arrhythmia syndromes and sports cardiology. In this episode, we review basic concepts of cardiovascular genomics and genetics in electrophysiology while discussing when to (and when not to!) test our patients and their families and how to approach those results. Audio editing by CardioNerds academy intern, Pace Wetstein. This episode was developed in collaboration with the American Society of Preventive Cardiology and is supported with unrestricted educational funds from Illumina, Inc. All CardioNerds content is planned, produced, and reviewed solely by CardioNerds. This CardioNerds Cardiovascular Genomics series is a multi-institutional collaboration made possible by contributions of stellar fellow leads and expert faculty from several programs. Pearls • Notes • References CardioNerds Cardiovascular Genomics PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - Genetics in Electrophysiology The first step is identifying the right phenotype! Getting the right phenotype is crucial, as genetic testing done in a patient without a clear phenotype (or an incorrect one) would lead to significant anxiety, unnecessary tests and interventions, and potentially misleading and dangerous conclusions for patients and their families. Genetic testing typically should be reserved for patients with a confirmed or suspected diagnosis of an inherited disease or for individuals with a previously diagnosed pathogenic variant in a first-degree relative.1 Discuss with your patient! Genetic counseling is essential and recommended for all patients before and after genetic testing. It should include a thorough discussion of risks, benefits, and possible outcomes, including variants of uncertain significance.2 Cardiovascular genetics is a dynamic and rapidly evolving field. New information can cause a variant of uncertain significance to be reclassified as a pathogenic or likely pathogenic variant or to be downgraded to benign or likely benign as variant databases expand. Another possibility is that new research might identify novel genes for a particular disease, which could warrant retesting, particularly for phenotype-positive and genotype-negative patients.1 Brugada syndrome is an inherited arrhythmogenic disorder characterized by ST-segment elevation in the right precordial leads and malignant ventricular arrhythmias, with occasional conduction disease and atrial arrhythmias. It is diagnosed in patients with ST-segment elevation ≥ 2 mm in ≥ 1 lead among the right precordial leads, with a type I morphology (J-point elevation with slowly descending or concave ST segment elevation merging into a negative T wave), shown in the image below. This pattern can be observed spontaneously or after provocative drug testing (e.g., procainamide). Pathogenic genetic variants in SCN5A that result in loss of function of the cardiac sodium channel are identified in approximately 20% of cases.3,4 Image adapted from Batchvarov VN. The Brugada Syndrome – Diagnosis, Clinical Implications and Risk Stratification. Eur Cardiol Rev. 2014;9(2):82. doi:10.15420/ECR.2014.9.2.82 Measure the QT interval yourself!