Podcasts about controlled trial

April 2025 Show Notes Drs. Jill Larson and Vineeta Swaroop from Northwestern University and Lurie Children's Hospital in Chicago join the podcast for a journal club-style discussion of their group's studies concerned with care for children with Spina Bifida and Neuromuscular Conditions. The lightening round articles touch on determination of femoral anteversion in the operating room, regional anesthesia for hip surgeries, and the value of tapping for pedicle screws during spine deformity surgery.   Your hosts are Craig Louer (Vanderbilt University), Carter Clement (Manning Family Children's Hospital in New Orleans), Tyler McDonald (University of South Alabama), and Will Morris (Scottish Rite for Children).   Main Event – Spina Bifida Journal Club   Dias LS, Swaroop VT, de Angeli LRA, Larson JE, Rojas AM, Karakostas T. Myelomeningocele: a new functional classification. J Child Orthop. 2021;15(1):1-5. doi:10.1302/1863-2548.15.200248   May JM, DeMaio EL, Larson JE. Long-term Clinical and Radiographic Results of Posteromedial Lateral Release for Neuromuscular Clubfoot Deformity. J Pediatr Orthop. 2025;45(2):87-92. doi:10.1097/BPO.0000000000002848   Poggiali P, May JM, Larson JE, Dias LS. Talectomy for the Treatment of Rigid Nonidiopathic Clubfoot Deformity: Long-term Follow-up. Journal of the Pediatric Orthopaedic Society of North America, Volume 9, 100112   Arkin C, Ihnow S, Dias L, Swaroop VT. Midterm Results of the Ponseti Method for Treatment of Clubfoot in Patients With Spina Bifida. J Pediatr Orthop. 2018;38(10):e588-e592. doi:10.1097/BPO.0000000000001248   Thompson RM, Foley J, Dias L, Swaroop VT. Hip Status and Long-term Functional Outcomes in Spina Bifida. J Pediatr Orthop. 2019;39(3):e168-e172. doi:10.1097/BPO.0000000000001266     Lightning Round   Yao B, Li D, Cui J, et al. Establishment of an Accurate and Precise Alternative Intraoperative Technique for Determination of Femoral Version. J Pediatr Orthop. Published online March 21, 2025. doi:10.1097/BPO.0000000000002920'   Reysner M, Reysner T, Janusz P, et al. Pericapsular Nerve Group (PENG) Block Versus Lumbar Erector Spinae Plane Block (ESPB) in Pediatric Hip Surgery: A Randomized, Double-Blinded, Controlled Trial. J Pediatr Orthop. 2025;45(4):e324-e330. doi:10.1097/BPO.0000000000002882   Tate A, Brouillet K, Braithwaite Iv HC, Luhmann SJ. Pedicle Screw Placement in Pediatric and Adolescent Spinal Deformity Surgery: Does Tapping of the Pedicle Screw Tract Increase Safety?. J Pediatr Orthop. 2025;45(5):269-273. doi:10.1097/BPO.0000000000002909

Send us a textEffects of liberal versus restrictive transfusion strategies on intermittent hypoxaemia in extremely low birthweight infants: secondary analyses of the ETTNO randomised controlled trial.Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, Krägeloh-Mann I, Essers J, Bührer C, Bittrich HJ, Roll C, Höhn T, Ehrhardt H, Boettger R, Körner HT, Stein A, Neuberger P, Henriksen TB, Greisen G, Poets CF; ETTNO Investigators.Arch Dis Child Fetal Neonatal Ed. 2025 Mar 26:fetalneonatal-2024-327643. doi: 10.1136/archdischild-2024-327643. Online ahead of print.PMID: 40139741As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textAzithromycin therapy for prevention of chronic lung disease of prematurity (AZTEC): a multicentre, double-blind, randomised, placebo-controlled trial.Lowe J, Gillespie D, Aboklaish A, Lau TMM, Consoli C, Babu M, Goddard M, Hood K, Klein N, Thomas-Jones E, Turner M, Hubbard M, Marchesi J, Berrington J, Kotecha S.Lancet Respir Med. 2024 Aug;12(8):608-618. doi: 10.1016/S2213-2600(24)00079-1. Epub 2024 Apr 25.PMID: 38679042 Free article. Clinical Trial. As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

As part of the March issue, the European Respiratory Journal presents the latest in its series of podcasts. Deputy Chief Editor Don Sin interviews Associate Editor Yet Khor about the generalisability of pharmaceutical randomised controlled trial eligibility criteria for progressive pulmonary fibrosis.

Send us a textWelcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast! This week, Dr. John Fralick and guest host Dr. Chunpeng Nie discuss two recent papers: resmetirom for the treatment of Nonalcoholic Steatohepatitis (NASH)—now known as Metabolic Dysfunction-Associated Steatohepatitis (MASH)—with liver fibrosis, and the effect of a Mediterranean diet on disease activity, inflammation, and the gut microbiome in patients with ulcerative colitis. Two papers, here we go!A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis (0:00 – 10:17)A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial (10:18– 15:45)And for the Good Stuff:Shoutout to all the MTU teams supporting their R1's! (15:46 – 16:20).For the 1st time in Canada, surgeons put teeth in patients' eyes to restore sight (16:21 – 17:56)Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

Episode: 2951 Scurvy, Vitamin C, and the Origins of the Modern Clinical Trial.  Today, we go to sea.

Admission to the intensive care unit (ICU) can be a challenging experience for patients and their families. Psychological burdens, including symptoms of anxiety, depression and post-traumatic stress, are among the most reported during the ICU stay.A recent study has been carried out as a joint project between France and the United States in which the experts have designed an intervention to improve outcomes for patients' families. For this intervention, they evaluated the nurse facilitator to support, model and teach communication strategies that will help in securing care aligned with patients' goals at the ICU. To learn more about this intervention, we interviewed one of the main authors, Nancy Kentish Barnes. Listen to our podcast for deeper insights into this study!

Todd Cartee, MD interviewed by Carlos A. Garcia, MD

Send us a textDiese Woche geht es im Journal Club um eine Arbeit von Köhl et al. aus Anaesthesia: Hyperangulated vs. Macintosh videolaryngoscopy in adults with anticipated difficult airway management: a randomised controlled trial. (doi:10.1111/anae.16326). Dabei geht es um den Vergleich unterschiedlicher Spatel bei der Videolaryngoskopie.Mit im Studio dabei: Konstantin Urbach, wissenschaftlicher Mitarbeiter der Klinik für Anästhesiologie am UKHD.

Now, as you can imagine, we get all sorts of questions about hormone health. We've compiled the Top 5 Questions about PCOS that commonly arise in our PCOS Recovery Program and Instagram.  My special guest is Cathy Chu, a hormone and digestion focused RD dietitian at The Good Life Dietitian. Cathy brings a wealth of experience and expertise in supporting patients with PCOS and overlapping functional gut disorders. In this episode, we answer the top questions: Is coffee harmful for your hormones? Why is it so hard to lose weight with PCOS? Can going gluten-free and dairy-free help with managing PCOS? What's the best diet for PCOS? What's the best exercise for PCOS? Resources: PCOS Recovery Program - Now Open for Enrolment (Starts October 2) Meet Cathy and Trista References: Bu FL, Feng X, Yang XY, Ren J, Cao HJ. Relationship between caffeine intake and infertility: a systematic review of controlled clinical studies. BMC Womens Health. 2020 Jun 16;20(1):125. doi: 10.1186/s12905-020-00973-z. PMID: 32546170; PMCID: PMC7298863. Juhász, A.E., Stubnya, M.P., Teutsch, B. et al. Ranking the dietary interventions by their effectiveness in the management of polycystic ovary syndrome: a systematic review and network meta-analysis. Reprod Health 21, 28 (2024). https://doi.org/10.1186/s12978-024-01758-5 Patel V, Menezes H, Menezes C, Bouwer S, Bostick-Smith CA, Speelman DL. Regular Mindful Yoga Practice as a Method to Improve Androgen Levels in Women With Polycystic Ovary Syndrome: A Randomized, Controlled Trial. J Am Osteopath Assoc. 2020 Apr 14. doi: 10.7556/jaoa.2020.050. Epub ahead of print. PMID: 32285088. Shele G, Genkil J, Speelman D. A Systematic Review of the Effects of Exercise on Hormones in Women with Polycystic Ovary Syndrome. J Funct Morphol Kinesiol. 2020 May 31;5(2):35. doi: 10.3390/jfmk5020035. PMID: 33467251; PMCID: PMC7739243.

Who couldn't use less stress in their life? Well, a great place to start is with cortisol—the stress hormone that simmers in the background and, over time, hinders your overall health. Our episode on quick ways to lower cortisol almost instantly has been our most downloaded episode ever since 2022. So this week we're bringing you 7 supplements to help you lower cortisol. Because sometimes taking a pill is just easier. As always with our podcast, each one is science-backed.    Fullscript Link to Recommended Supplements  Get links to our recommendations plus 20% your entire supplement order through Happy Eating dispensary at Fullscript. If you click on links we provide through Fullscript, we may receive compensation. https://us.fullscript.com/welcome/happyeating    LISTEN: 7 Things That Low Cortisol (Almost) Instantly   LISTEN: Ashwagandha: The Supplement You Need in 2022   References Mentioned:  A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study Omega-3 Supplementation and Stress Reactivity of Cellular Aging Biomarkers: An Ancillary Substudy of a Randomized, Controlled Trial in Midlife Adults   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com Learn More About Our Hosts:  Carolyn Williams PhD, RD: Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeatingpodcast@gmail.com Produced by Lester Nuby OE Productions  

Who couldn't use less stress in their life? Well, a great place to start is with cortisol—the stress hormone that simmers in the background and, over time, hinders your overall health. Our episode on quick ways to lower cortisol almost instantly has been our most downloaded episode ever since 2022. So this week we're bringing you 7 supplements to help you lower cortisol. Because sometimes taking a pill is just easier. As always with our podcast, each one is science-backed.    Fullscript Link to Recommended Supplements  Get links to our recommendations plus 20% your entire supplement order through Happy Eating dispensary at Fullscript. If you click on links we provide through Fullscript, we may receive compensation. https://us.fullscript.com/welcome/happyeating    LISTEN: 7 Things That Low Cortisol (Almost) Instantly   LISTEN: Ashwagandha: The Supplement You Need in 2022   References Mentioned:  A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study Omega-3 Supplementation and Stress Reactivity of Cellular Aging Biomarkers: An Ancillary Substudy of a Randomized, Controlled Trial in Midlife Adults   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com Learn More About Our Hosts:  Carolyn Williams PhD, RD: Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeatingpodcast@gmail.com Produced by Lester Nuby OE Productions  

The draft order:Sophia AmbrusoNayan AroraSwapnil HiremathAC GomezJoel TopfEditor Nayan AroraShow NotesPrevious drafts:2021 KDIGO Hypertension —Joel, Sophia, Swap, Nayan, Josh2021 ASN Kidney Week Draft—Joel, Sophia, Swap, Nayan, Jennie2022 The ISPD Peritonitis Guideline— Joel, Sophia, Swap, Nayan2022 ASN Kidney Week Draft—Joel, Sophia, Swap, Nayan2023 ASN Kidney Week Draft—Joel, Sophia, Swap, Nayan, AC, Josh2024 KDIGO CKD Clinical Practice Guideline —Joel, Sophia, Swap, Nayan, Josh, ACThe guidelineThe NephJC discussion Part 1 | Part 2First RoundSophia's Pick 3.7.1 We recommend treating patients with type 2 diabetes (T2D), CKD, and an eGFR ≥20 ml/min per 1.73 m2 with an SGLT2i (1A).Not Nayan's Pick 3.7.3: We suggest treating adults with eGFR 20 to 45 ml/min per 1.73 m2 with urine ACR

Coronary Sinus Reducer for the Treatment of Refractory Angina: A Randomized, Placebo-Controlled Trial (ORBITA-COSMIC)

Technology supported learning. Read the accompanying article here: https://doi.org/10.1111/medu.15198

A Double-blind, Randomized Placebo Procedure-controlled Trial Of An Interatrial Shunt In Patients With HfrEF And HfpEF: Principal Results From The RELIEVE-HF Trial

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update   discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. Welcome to diabetes core update where every month we go over the most important articles to come out in the field of diabetes. Articles that are important for practicing clinicians to understand to stay up with the rapid changes in the field.  This issue will review: 1.     A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis 2.     Long-Term Outcomes of Medical Management vs Bariatric Surgery in Type 2 Diabetes 3.     Improved Glycemic Outcomes With Diabetes Technology Use Independent of Socioeconomic Status in Youth With Type 1 Diabetes 4.     Cardiovascular and Kidney Risks in Individuals With Type 2 Diabetes: Contemporary Understanding With Greater Emphasis on Excess Adiposity 5.     Epidemiology and Prognostic Implications of Coronary Artery Calcium in Asymptomatic Individuals With Prediabetes   For more information about each of ADA's science and medical journals, please visit www.diabetesjournals.org. Hosts: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

Today, I'd like to share information about a registered randomized controlled trial on ClinicalTrials.gov named "LIPLEG."Conducted by a group of physicians and researchers in Germany, the trial aims to assess the effectiveness and safety of liposuction in comparison to standard complete decongestive therapy (CDT) treatments for lipedema.

Does the type and quality of dietary fat affect body composition and weight loss? In today's episode, I want to examine a recent study with 32 female participates looking at recommended vs consumed fat intake and different dietary fats consumed. We'll also discuss the real world application of this study including cooking oil swaps, meals and snacks, and more. Topics include:    - Food Quality, Body Composition, and Weight Loss - Examining a Randomized Controlled Trial Study - 32 Females In The Study Population and Fat Consumption - Recommended vs Consumed Fat Intake - Substituting Cooking Oils and Alternatives - Avocado Toast and Other Healthy Fat Options - Main Message on Dietary Fat Swaps - Please Share, Rate, and Review ----------  Attend My Free "The Future of Functional Nutrition" Workshop on February 1st, 2024: https://clients.sammillerscience.com/future ----------  Subscribe to My New Youtube Channel:  https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1 ----------  My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization  www.metabolismschool.com ----------     [Free] Metabolism School 101: The Video Series http://www.metabolismschool.com/metabolism-101     ----------     Grab a Copy of My New Book - Metabolism Made Simple     ----------   Stay Connected:     Instagram: @sammillerscience     Youtube: SamMillerScience     Facebook: The Nutrition Coaching Collaborative Community     TikTok: @sammillerscience       ---------- “This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at team@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."  

In this episode of the Award-winning PRS Journal Club Podcast, 2024 Resident Ambassadors to the PRS Editorial Board – Rami Kantar, Yoshi Toyoda, and Amanda Sergesketter- and special guest Amy Colwell, MD, discuss the following articles from the January 2024 issue: “Assessing the Efficacy of the S-PECS Block in Breast Augmentation Surgery: A Randomized, Double-Blind, Controlled Trial” by Sforza, Saghir, Saghir, et al. Read the article for FREE: https://bit.ly/S-PECSBlock Special guest Amy Colwell, MD, from Massachusetts General Hospital (MGH) and Harvard University. Dr. Colwell is a plastic surgeon specializing in breast reconstruction, aesthetic breast surgery, and body contouring at MGH while also serving as a Co-editor for PRS Journal. She completed her general surgery training at the Brigham and Women's Hospital followed by plastic surgery training in the Harvard combined training program. READ the articles discussed in this podcast as well as free related content: https://bit.ly/JCJan24Collection    

JAACAP January 2024: Contributing Editor Dr. Deepika Shaligram interviews Dr. Emilio A. Valadez on a fMRI follow-up of a randomized clinical trial where 8- to 12-yearolds whose parents received Attachment and Biobehavioral Catch-up (ABC) intervention when children were infants showed more matured patterns of brain connectivity and brain activation than children whose parents received a control intervention.

Host Dr. Michael Blankstein interviews paper author Dr. David Cinats. This paper was presented at the 2023 OTA Annual Meeting.  To see the abstract while listening, download the free ConveyMED app : Apple Store click here Google Play click here. For additional educational resources visit https://ota.org/

Dr. John Fleetham chats with Dr. Paula K. Schweitzer and Dr. Najib Ayas about their articles, "The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial" and "Pharmacologic Therapy for Obstructive Sleep Apnea: Are We Seeing Some Light at the End of the Tunnel?"

AHA23 Congress Coverage: PCI for Stable Angina (ORBITA-2 Trial)

Who couldn't use less stress in their life? Well, a great place to start is with cortisol—the stress hormone that simmers in the background and, over time, hinders your overall health. Our episode on quick ways to lower cortisol almost instantly has been our most downloaded episode ever since 2022. So this week we're bringing you 7 supplements to help you lower cortisol. Because sometimes taking a pill is just easier. As always with our podcast, each one is science-backed.    Fullscript Link to Recommended Supplements  Get links to our recommendations plus 20% your entire supplement order through Happy Eating dispensary at Fullscript. If you click on links we provide through Fullscript, we may receive compensation. https://us.fullscript.com/welcome/happyeating    LISTEN: 7 Things That Low Cortisol (Almost) Instantly   LISTEN: Ashwagandha: The Supplement You Need in 2022   References Mentioned:  A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study Omega-3 Supplementation and Stress Reactivity of Cellular Aging Biomarkers: An Ancillary Substudy of a Randomized, Controlled Trial in Midlife Adults   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com Learn More About Our Hosts:  Carolyn Williams PhD, RD: Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeatingpodcast@gmail.com Produced by Lester Nuby OE Productions  

Host Dr. Gerard Slobogean interviews paper author Dr. Prism Schneider. This paper was presented at the 2023 OTA Annual Meeting. To see the abstract while listening, download the free ConveyMED App: Apple Store click here Google Play click here. For additional educational resources visit https://ota.org/

Pim Aarts, MD interviewed by Olayemi Sokumbi, MD, FAAD

Hello everyone welcome to the Dr Nirvana Podcast™, I'm Dr. Nirvana!  There's a certain type of light that I wanted to discuss today that's vital to our body's healing powers.  Known for its remarkably powerful form of energy, red light provides incredible benefits to your body. On today's episode I discuss which parts of your health it impacts, how and my favorite red light device on the market today.Sources: (1)  1Jiang, M. et. al. (2017). A prospective study of the safety and efficacy of a combined bipolar radiofrequency, intense pulsed light, and infrared diode laser treatment for global facial photoaging. Lasers in Medicine and Science, 32(5):1051-1061(2)  Kim, Hee-Kyong. (2017). Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheek. Journal I Physical Therapy and Science, 29(2): 290–294.(3)  Pinar, Avci. Low-level laser (light) therapy (red and near-infrared light) in skin: stimulating, healing, restoring. SCMS, 32(1): 41-52.(4)  84Barolet, D. (2009). Ba Regulation of Skin Collagen Metabolism In Vitro using a Pulsed 660 nm LED Light Source: Clinical Correlation with a Single-Blinded Study, Journal of Investigative Dermatology, 129(12): 2751-2759.(5)  Wunsch, A. (2014). A Controlled Trial to Determine the Efficacy of Red and near-infrared light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase. Photomedicine in Lasers and Surgery, 32(2): 93–100.(6)   Fabiana do Socorro da Silva Dias Andrade et al. (2014) Effects of low-level laser therapy on wound healing(7)  Jiang, M. et. al. (2017). A prospective study of the safety and efficacy of a combined bipolar radiofrequency, intense pulsed light, and infrared diode laser treatment for global facial photoaging. Lasers in Medicine and Science, 32(5):1051- 1061.(8) Thyroid Health https://pubmed.ncbi.nlm.nih.gov/20662037/(9) Hair Growth https://www.jaad.org/article/S0190-9622(06)03382-2/fulltext, https://pubmed.ncbi.nlm.nih.gov/24474647/(10) Liver Regeneration https://www.liebertpub.com/doi/abs/10.1089/pho.2009.2756(11) Depression/Anxiety https://pubmed.ncbi.nlm.nih.gov/19995444/For questions on this episode or other inquiries please feel free to contact me at Instagram or Facebook page.For appointments, please click here.

Listen to our interview with Dr. Oshri Barel, the author of "Addition of Lidocaine to the Distension Medium in Hysteroscopy Decreases Pain during the Procedure –A Randomized Double-blind, Placebo-controlled Trial". In this episode, we discuss the intervention of adding lidocaine to hysteroscopy distention medium and its effect on pain from the procedure. See below for publication details and be sure to join discussion on this topic through our social media platforms.Publication details: VOLUME 28, ISSUE 4, P865-871, APRIL 2021Full text linkConnect with the JMIG Social Media Team!X: @AAGLJMIGInstagram: @AAGLJMIGFacebook: AAGLJMIG

Andrew Blauvelt, MD, FAAD interviewed by Jackie Dosal, MD, FAAD

Experts Drs Matthew A. Sparks and Dana V. Rizk discuss the pathology, presentation, and management of IgA nephropathy. Looking for the latest on clinical trials and approved treatments? Tune in! Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/991603). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Chronic Kidney Disease (CKD) https://emedicine.medscape.com/article/238798-overview IgA Nephropathy https://emedicine.medscape.com/article/239927-overview Polycystic Kidney Disease https://emedicine.medscape.com/article/244907-overview Biomarkers for IgA Nephropathy on the Basis of Multi-Hit Pathogenesis https://pubmed.ncbi.nlm.nih.gov/29740706/ Galactose-Deficient IgA1 as a Candidate Urinary Marker of IgA Nephropathy https://pubmed.ncbi.nlm.nih.gov/35683557/ Immunological Drivers of IgA Nephropathy: Exploring the Mucosa-Kidney Link https://pubmed.ncbi.nlm.nih.gov/34821031/ Nephrotic Syndrome https://emedicine.medscape.com/article/244631-overview Podocytopathies https://pubmed.ncbi.nlm.nih.gov/32792490/ Minimal-Change Disease https://emedicine.medscape.com/article/243348-overview IgA Vasculitis (Henoch-Schönlein Purpura) https://emedicine.medscape.com/article/984105-overview Sodium-Glucose Transport Protein 2 (SGLT2) Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK576405/ Dapagliflozin in Patients With Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/32970396/ Empagliflozin in Patients With Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/36331190/ A Controlled Trial of Fish Oil in IgA Nephropathy. Mayo Nephrology Collaborative Group https://pubmed.ncbi.nlm.nih.gov/7935657/ Fish Consumption, Omega 3 Fatty Acids and Cardiovascular Disease. The Science and the Clinical Trials https://pubmed.ncbi.nlm.nih.gov/19326716/ Tonsillectomy in a European Cohort of 1,147 Patients With IgA Nephropathy https://pubmed.ncbi.nlm.nih.gov/26586175/ Sparsentan in Patients With IgA Nephropathy: A Prespecified Interim Analysis From a Randomised, Double-Blind, Active-Controlled Clinical Trial https://pubmed.ncbi.nlm.nih.gov/37015244/ Intensive Supportive Care Plus Immunosuppression in IgA Nephropathy https://pubmed.ncbi.nlm.nih.gov/26962737/ Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/28763548/ Targeted-Release Budesonide Versus Placebo in Patients With IgA Nephropathy (NEFIGAN): A Double-Blind, Randomised, Placebo-Controlled Phase 2b Trial https://pubmed.ncbi.nlm.nih.gov/28363480/ Results From Part A of the Multi-Center, Double-Blind, Randomized, Placebo-Controlled NefIgArd Trial, Which Evaluated Targeted-Release Formulation of Budesonide for the Treatment of Primary Immunoglobulin A Nephropathy https://pubmed.ncbi.nlm.nih.gov/36270561/ Crescents and IgA Nephropathy: A Delicate Marriage https://pubmed.ncbi.nlm.nih.gov/35806856/ Crescentic, Proliferative IgA Nephropathy: Clinical and Histological Response to Methylprednisolone and Intravenous Cyclophosphamide https://pubmed.ncbi.nlm.nih.gov/12808169/ Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury https://pubmed.ncbi.nlm.nih.gov/33936063/ New Treatment Strategies for IgA Nephropathy: Targeting Plasma Cells as the Main Source of Pathogenic Antibodies https://pubmed.ncbi.nlm.nih.gov/35628935/

2023 OJSM William A. Grana Award for Best Research Paper spotlight - Dr. Olufemi Ayeni from McMaster University Medical Centre in Ontario joins us to discuss his award-winning study “Effect of Osteochondroplasty on Time to Reoperation After Arthroscopic Management of Femoroacetabular Impingement: Analysis of a Randomized Controlled Trial." As hip arthroscopy continues to grow as a beneficial treatment option in Sports Medicine, high level evidence is needed to support its efficacy.  Dr. Ayeni and his group provide high quality data supporting the long term benefits of osteochondroplasty versus soft tissue work alone.

Drs John M. Kane and Delbert G. Robinson discuss psychoeducation, treatment options, and possible side effects of medication for patients experiencing their first episode of schizophrenia. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984489). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Schizophrenia https://emedicine.medscape.com/article/288259-overview First-Episode Schizophrenia https://pubmed.ncbi.nlm.nih.gov/21141653/ Comprehensive Versus Usual Community Care for First Episode Psychosis: Two-Year Outcomes From the NIMH RAISE Early Treatment Program https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981493/ Schizophrenia Treatment & Management https://emedicine.medscape.com/article/288259-treatment#d9 Akinesia https://pubmed.ncbi.nlm.nih.gov/32965848/ Clozapine (Rx) https://reference.medscape.com/drug/clozaril-versacloz-clozapine-342972 20-year Nationwide Follow-up Study on Discontinuation of Antipsychotic Treatment in First-Episode Schizophrenia https://pubmed.ncbi.nlm.nih.gov/29621900/ A Randomized, Controlled Trial of Omega-3 Fatty Acids Plus an Antioxidant for Relapse Prevention After Antipsychotic Discontinuation in First-Episode Schizophrenia https://pubmed.ncbi.nlm.nih.gov/24996507/ Beneficial Effects of Omega-3 Fatty Acid Supplementation in Schizophrenia: Possible Mechanisms https://pubmed.ncbi.nlm.nih.gov/32620164/ An Overview of Coordinated Specialty Care (CSC) for Persons With First Episode Psychosis https://www.nasmhpd.org/content/presentation/overview-coordinated-specialty-care-csc-persons-first-episode-psychosis

Commentary by Social Media Editor Anju Bhardwaj

Drs. Nick Strasser and Joe Park co-host this conversation with award winner Andrew J. Goldberg, OBE, MD, FRCS(Tr&Orth). This paper was presented live at the 2022 AOFAS Annual Meeting in Quebec City. For additional educational resources, visit: https://aofas.org Looking for CME? AOFAS Podcast CME only on the ConveyMED Podcast App: Apple Store click here Google Play click here

Commentary by Dr. Valentin Fuster

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Predicting the cost-effectiveness of running a randomized controlled trial, published by Falk Lieder on April 17, 2023 on The Effective Altruism Forum. TLDR: Research is underrated. Running an RCT to evaluate a digital intervention for promoting altruism could be more than 10x as cost-effective as the best charities working on global health and wellbeing. In the previous post, we found that – in expectation – Baumsteiger's (2019) intervention for promoting altruism is about 4x as cost-effective as GiveDirectly but lower than the cost-effectiveness of the Against Malaria Foundation or StrongMinds. However, the uncertainty about the actual cost-effectiveness of this intervention is still extremely high. The uncertainty is, in fact, so high that the 95% credible interval on the cost-effectiveness of the new intervention ranges from -0.5 WELLBYs/$1000 to 88 WELLBYs/$1000. The upper bound of this credible interval is close to the cost-effectiveness of the presumably most cost-effective mental health charity StrongMinds (90 WELLBYs/$1000; Plant, 2022), and more than twice the cost-effectiveness of the Against Malaria Foundation (39 WELLBYs/$1000; Plant, 2022). Based on these estimates, there is a 5% chance that the intervention might be harmful and a more than 5% chance that it might be at least as cost-effective as the charities recommended by GiveWell and the Happier Lives Institute. Because of this high uncertainty, any decisions based on the current state of knowledge could be highly suboptimal compared to what we would do if we had additional information. However, information can be costly, especially when running a randomized controlled trial (RCT). And the more money we spend on information, the less we can spend on saving lives. This dilemma raises the question, “When is it worthwhile to run an RCT to gather more data, and when should we exploit what we already know?” To answer this question, we introduce a new method for predicting the cost-effectiveness of gaining new information through an RCT and comparing it to the cost-effectiveness of cash transfers and directly promoting global health and well-being. We illustrate this method using the intervention by Baumsteiger (2019) as an example. However, the approach we are illustrating is more general and can also be applied to RCTs on established, emerging, and yet unknown EA interventions, including deworming, motivating parents to vaccinate their children, water purification, and interventions for improving mental health. We develop our method in two steps. First, we apply the established Value of Information framework (Howard, 1966) to obtain an upper bound on the cost-effectiveness of running an RCT. Then, we replace this method's unrealistic assumption of perfect information with more realistic assumptions about the imperfect information generated by an RCT. This yields a new method that can provide more accurate estimates of the cost-effectiveness of evaluation research. As a proof of concept, we apply this method to predict how cost-effective it would be to evaluate the altruism intervention based on Baumsteiger (2019) in RCTs with different numbers of participants. Our method predicts that running such an RCT with 1200 participants would be highly cost-effective. This post is a brief summary of the longer report presented in this interactive notebook. How valuable would it be to know the true exact value of the cost-effectiveness of the intervention by Baumsteiger (2019)? To obtain an upper bound on how valuable it might be to evaluate the intervention by Baumsteiger (2019), I first calculate the value of obtaining perfect information about its cost-effectiveness. The value of perfect information is an established mathematical concept introduced by Howard (1966). It has recently been applied to charity evalu...

Lauren Southwick, M.P.H., and Sharath Guntuku, Ph.D., join Dr. Dixon and Dr. Berzin to discuss whether using a digital dashboard maintained by patients to track social media and other digital data usage had an impact on mental health therapy outcomes. •    Southwick and Guntuku interview [01:37] •    What led you to this study design? [03:06] •    What did you think this would look like in a therapy setting? [08:00] •    Amount of data patients contributed varied widely [09:39] •    The dashboard [10:12] •    What were the effects of sharing digital data with therapists? [12:31] •    The Hawthorne effect [15:25] •    What's next for your research? [18:23] •    Recruitment [20:46] •    COVID and people's interactions with digital media and mental health [23:29] •    ChatGPT [26:50] Transcript Subscribe to the podcast here. Check out Editor's Choice, a set of curated collections from the rich resource of articles published in the journal. Sign up to receive notification of new Editor's Choice collections. Browse other articles on our website. Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it. Listen to other podcasts produced by the American Psychiatric Association. Follow the journal on Twitter. E-mail us at psjournal@psych.org  

Episode: 2951 Scurvy, Vitamin C, and the Origins of the Modern Clinical Trial.  Today, we go to sea.

Dr. Michael Lanspa chats with Dr. Yahya Shehabi about his article, "Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)."

Biologics and the Peripheral Nerve.   Claim CME The CE experience for this Podcast is powered by CMEfy - click here to reflect and earn credits: https://earnc.me/TgB18M   Dr. Rosenblum discuss his upcoming talk at the Appalachian Region Spine and Pain Meeting:  Incorporating Ultrasound into a Spine and Pain Practice on April 14-16 2023 and the topics he plans to include: Ultrasound Guided Knee therapies, cluneal nerve, caudal, brachial plexus and more!   Today's podcast (inspired by TOBI and Dr. Sudhir Diwan, Dr. Sheldon Jordon and Dr. Rikin Patel's ASIPP Lectures)  focuses on the risk and benefits of performing PRP injection onto a nerve.  Dr. Rosenblum discusses:    Possible fibrosis of the ulna nerve after using PRP for partial ulnar collateral ligament tears  Best Time for PRP Injection after Nerve Regeneration  Alpha 2-macroglobulin (what is it?)  PRP for moderate to severe carpal tunnel syndrome   Featured Courses!   May 25, 2023 Private Pain Group   Ultrasound Course- NYC (Sold out) Ultrasound Guided Regional Anesthesia and Pain Medicine NYC- April 22, 2023 Regenerative Pain Medicine Course NYC- May 13 Pain Management Board Review/Refresher Course/ Ultrasound Training NYC- June 9-11, 2023 see the full schedule for our July and August US IPM Courses!   References Robert G. Thompson, Kendall Bradley, Gary M. Lourie, Ulnar nerve dysfunction at the elbow after platelet-rich plasma treatment for partial ulnar collateral ligament injuries,JSES Reviews, Reports, and Techniques,Volume 1, Issue 1,2021,Pages 41-44,ISSN 2666-6391,   Si-Ru Chen, Yu-Ping Shen, Tsung-Yen Ho, Tsung-Ying Li, Yu-Chi Su, Yu-Ching Chou, Liang-Cheng Chen, Yung-Tsan Wu,One-Year Efficacy of Platelet-Rich Plasma for Moderate-to-Severe Carpal Tunnel Syndrome: A Prospective, Randomized, Double-Blind, Controlled Trial,Archives of Physical Medicine and RehabilitationVolume 102, Issue 5,2021, Pages 951-958,ISSN 0003-9993,https://doi.org/10.1016/j.apmr.2020.12.025.   Rehman, A.A., Ahsan, H. and Khan, F.H. (2013), Alpha-2-macroglobulin: A physiological guardian. J. Cell. Physiol., 228: 1665-1675. https://doi.org/10.1002/jcp.24266   Muhammad Pandunugrahadi, Komang Agung Irianto, Oen Sindrawati, "The Optimal Timing of Platelet-Rich Plasma (PRP) Injection for Nerve Lesion Recovery: A Preliminary Study", International Journal of Biomaterials, vol. 2022, Article ID 9601547, 7 pages, 2022. https://doi.org/10.1155/2022/9601547

Biologics and the Peripheral Nerve.   Claim CME The CE experience for this Podcast is powered by CMEfy - click here to reflect and earn credits: https://earnc.me/TgB18M   Dr. Rosenblum discuss his upcoming talk at the Appalachian Region Spine and Pain Meeting:  Incorporating Ultrasound into a Spine and Pain Practice on April 14-16 2023 and the topics he plans to include: Ultrasound Guided Knee therapies, cluneal nerve, caudal, brachial plexus and more!   Today's podcast focuses on the risk and benefits of performing PRP injection onto a nerve.  Dr. Rosenblum discusses:    Possible fibrosis of the ulna nerve after using PRP for partial ulnar collateral ligament tears  Best Time for PRP Injection after Nerve Regeneration  Alpha 2-macroglobulin (what is it?)  PRP for moderate to severe carpal tunnel syndrome   Featured Courses!   May 25, 2023 Private Pain Group   Ultrasound Course- NYC (Sold out)   Ultrasound Guided Regional Anesthesia and Pain Medicine NYC- April 22, 2023 Regenerative Pain Medicine Course NYC- May 13 Pain Management Board Review/Refresher Course/ Ultrasound Training NYC- June 9-11, 2023 see the full schedule for our July and August US IPM Courses!   References Robert G. Thompson, Kendall Bradley, Gary M. Lourie, Ulnar nerve dysfunction at the elbow after platelet-rich plasma treatment for partial ulnar collateral ligament injuries,JSES Reviews, Reports, and Techniques,Volume 1, Issue 1,2021,Pages 41-44,ISSN 2666-6391,   Si-Ru Chen, Yu-Ping Shen, Tsung-Yen Ho, Tsung-Ying Li, Yu-Chi Su, Yu-Ching Chou, Liang-Cheng Chen, Yung-Tsan Wu,One-Year Efficacy of Platelet-Rich Plasma for Moderate-to-Severe Carpal Tunnel Syndrome: A Prospective, Randomized, Double-Blind, Controlled Trial,Archives of Physical Medicine and RehabilitationVolume 102, Issue 5,2021, Pages 951-958,ISSN 0003-9993,https://doi.org/10.1016/j.apmr.2020.12.025.   Rehman, A.A., Ahsan, H. and Khan, F.H. (2013), Alpha-2-macroglobulin: A physiological guardian. J. Cell. Physiol., 228: 1665-1675. https://doi.org/10.1002/jcp.24266   Muhammad Pandunugrahadi, Komang Agung Irianto, Oen Sindrawati, "The Optimal Timing of Platelet-Rich Plasma (PRP) Injection for Nerve Lesion Recovery: A Preliminary Study", International Journal of Biomaterials, vol. 2022, Article ID 9601547, 7 pages, 2022. https://doi.org/10.1155/2022/9601547

Surgery along with chemotherapy is the mainstay of treatment for patients with osteosarcoma. In order to achieve a cure, during surgery healthy tissue surrounding the tumour is also removed. Whilst this reduces the chances of the cancer returning, it can also result in added pain and disability for patients, impacting their quality of life in the longer-term. Advancements in surgical technology and technique offer the hope of improved outcomes for patients. Recent developments have led to the introduction of fluorescence guided surgery (FGS), a technique which harnesses the emission of light to identify a tumour's precise location and boundaries during surgical removal. This improves a surgeon's ability to successfully remove the entire tumour, which can be identified as a ‘glowing' area of tissue, decreasing the likelihood of any cancer cells remaining, while limiting the removal of too much healthy tissue. This upcoming clinical trial, led by Kenneth Rankin, a leading Consultant Orthopaedic Surgeon and bone sarcoma researcher, is looking to assess the effectiveness of a particular fluorescent dye, indocyanine green or ‘ICG', which can be given to patients safely before surgery and leads to the sarcoma tumour fluorescing green. The SarcoSIGHT trial will recruit 500 patients undergoing surgery for bone and soft tissue sarcoma, aiming to test whether the use of ICG in FGS can help to accurately identify the tumour, aid in complete removal and reduce the amount of healthy tissue removed. This presentation will include the findings to date from fluorescence guided surgery in osteosarcoma patients with some initial results indicating that the amount of fluorescence may predict response to chemotherapy and that the osteosarcoma tissue can be studied in detail post-operatively with the latest fluorescence microscopy techniques. --- Mr Kenneth Rankin is a Consultant Orthopaedic Surgeon at Newcastle's Freeman Hospital where his specialist interests are in orthopaedic oncology including fluorescence guided surgery for sarcoma resection, and hip and knee replacement for arthritis. Mr Rankin graduated in 1999 from the University of Dundee. His basic surgical training was in Newcastle followed by an MD investigating the cellular biology of bone metastases. Mr Rankin completed his higher specialist training in Perth and Dundee followed by a return to the North East as NIHR Academic Clinical Lecturer. His current post as Consultant Orthopaedic Surgeon and Honorary Senior Lecturer is comprised mainly of orthopaedic oncology including the surgical management of bone and soft tissue sarcomas and metastatic bone disease. He also carries out hip and knee replacements for arthritis. As a Clinical Scientist Mr Rankin has developed an international reputation for translational research for the detection of circulating tumour cells in sarcoma patients and carried out the world's first case series of fluorescence guided surgery in sarcoma. Working in close collaboration with scientists at Newcastle University, he leads on basic and translational sarcoma research at the Newcastle Centre for Cancer.

Despite recent advances in arthroscopic rotator cuff repair, the retear rate remains high. New methods to optimize healing rates must be sought. Bone channeling may create a quicker and more vigorous healing response by attracting autologous mesenchymal stem cells, cytokines, and growth factors to the repair site.   In conclusion, this trial did not demonstrate the superiority of intraoperative bone channeling in rotator cuff repair over standard rotator cuff repair at 24 months postoperatively. Healing rates, patient-reported function, and quality-of-life outcomes were similar between groups.   Click here to read the article.

In this episode, host Dr. Sarah Wise speaks with Dr. Carol Yan and Dr. Zara Patel. They will discuss article: Use of platelet-rich plasma for COVID-19–related olfactory loss: a randomized controlled trial. Read the article in International Forum of Allergy and Rhinology. Listen and subscribe for free on Apple Podcasts , Google Podcasts and Subscribe on Android.

The Effect of Patient Positioning on Ureteral Efflux During Intraoperative Cystoscopy: a Randomized Controlled Trial w/ Dr. Sheena Galhotrahttps://www.jmig.org/article/S1553-4650(22)00363-6/fulltext 

Happy Wednesday, friends! Today on the podcast, Janell and Zoé have a conversation with friend of the podcast Allen Crostic! Allen shares about his own faith journey and the miraculous way he came to know Jesus. Zoé shares about her own faith journey and the things that are interesting to her about Christianity. This episode has a lot of great information about logic and premises, the relationship between Naturalism and miracles, deciphering what evidence for God can look like, and much more! We hope you enjoy this episode! _______We would love to thank our Patrons for all their amazing support! To learn more about supporting Finding Something REAL via Patreon, click here! If you are interested in becoming a co-host, click here! To follow Finding Something REAL on instagram, click here! FSR October 2021 with Allen (The Bible & A Believing Loyalty)FSR October 2021 with Allen (Holidays and Reclaiming things for God)FSR March 2021 with AllenFSR February 2021 with AllenFSR April 2020 with AllenGary HabermasWilliam Lane CraigAntony FlewKalam Cosmological ArgumentThe Teleological Argument for GodMiracles - Craig KeenerMiracles Today - Craig KeenerReasonable Faith Cold Case Christianity A list of short animated videos on these subjects from YouTubeImpact 360Therapeutic Effects of Intercessory Prayer in a Coronary Care Unit PopulationA Randomized, Controlled Trial of the Effects of Remote, Intercessory Prayer on Outcomes in Patients Admitted to the Coronary Care UnitProverbs 3:5-6”Trust in the Lord with all your heart,And lean not on your own understanding; In all your ways acknowledge Him,And He shall direct your paths.”Acts 17:26-27”And He has made from one blood every nation of men to dwell on all the face of the earth, and has determined their preappointed times and the boundaries of their dwellings, so that they should seek the Lord, in the hope that they might grope for Him and find Him, though He is not far from each one of us…”

In this week's podcast, John Mandrola, MD, discusses the PROTECTED TAVR trial, renal denervation, left atrial appendage closure and deprescribing aspirin. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Cerebral Embolic Protection After TAVI - Clear Stroke Benefit Eludes Embolic Protection: PROTECTED TAVR https://www.medscape.com/viewarticle/980978 - Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement https://www.nejm.org/doi/10.1056/NEJMoa2204961 - Protection Against Cerebral Embolism During Transcatheter Aortic Valve Replacement https://doi.org/10.1016/j.jacc.2016.10.023 - Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa1908655 - Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2208681 - Randomised Trial Of Intravenous Streptokinase, Oral Aspirin, Both, Or Neither Among 17 187 Cases Of Suspected Acute Myocardial Infarction: Isis-2 https://doi.org/10.1016/S0140-6736(88)92833-4 II Renal Denervation - Legacy of Neutral Renal Denervation Trial Recast by Long-term Outcomes: SYMPLICITY HTN-3 https://www.medscape.com/viewarticle/981062 - Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial https://doi.org/10.1016/S0140-6736(22)01787-1 - A systematic review, meta-analysis, and meta regression of the sham controlled renal denervation randomized controlled trials https://doi.org/10.1016/j.tcm.2022.05.009 - Legacy of Neutral Renal Denervation Trial Recast by Long-term Outcomes: SYMPLICITY HTN-3 https://www.medscape.com/viewarticle/981062 - A Controlled Trial of Renal Denervation for Resistant Hypertension https://www.nejm.org/doi/10.1056/NEJMoa1402670 III Percutaneous Left Atrial Appendage Occlusion (LAAO) - Amulet, Watchman 2.5 LAAO Outcomes Neck and Neck at 3 Years https://www.medscape.com/viewarticle/981199 - Consider Life Expectancy When Referring for LAA Closure? https://www.medscape.com/viewarticle/981117 - Incidence and Predictors of Early Death in Patients Undergoing Percutaneous Left Atrial Appendage Closure https://www.jacc.org/doi/full/10.1016/j.jacep.2022.06.012 IV Deprescribing Aspirin - Deprescribing Aspirin for Warfarin Patients May Reduce Bleeding https://www.medscape.com/viewarticle/981243 - Assessment of an Intervention to Reduce Aspirin Prescribing for Patients Receiving Warfarin for Anticoagulation https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2796492 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Drs Spiker and Scott discuss Automated Text-Messaging After Hip Arthroscopy: A Randomized-Controlled Trial of “Post-Op Buddy"