Podcasts about ns1

Vážené dámy a vážení pánové, je to tady! Super Bowl s pořadovým číslem 59 se nám přiblížil doslova na dotyk ruky. Je to poslední zápas letošní sezóny, na který si můžeme udělat preview. Poslední utkání před dlouhým obdobím čekání. Budeme svědky historického třetího vítězství v Super Bowlu v podaní Kansas City Chiefs? Nebo jim žhavá akvizice letošní sezony Saquon Barkley překazí plány? To vše si rozebereme tradičně v 17:45 na našem Youtube. A jak jsme předesílali minule, tentokrát budeme soutěžit o 65 palcovou 4K OLED televizi! Takže určitě přijďte živě, jinak nemáte šanci vyhrát! ----------------------------------- OBSAH: 0:00:09 Úvod0:03:32 Polemika nad Tom Brady Trophy0:05:52 Super Bowl LIX0:06:57 Noriho okno informacím dokořán0:22:21 Chiefs vs Eagles (Super Bowl LIX, Telly TV zápas kola, NS1)1:25:12 Komerční odbočka aneb díků vzdání partnerům projektu NFL.cz1:28:14 Sázkařské okénko s Fortunou 

I v čase vánočním přínašíme naše pravidelné virtuální studio. Budeme se pochopitelně povídat o bramborovém salátu, kaprovi, řízcích a dárcích. A možná taky trocho o fotbalu, protože NFL samozřejmě nikdy nespí a v těchto dnech nás čeká velká nálož napínavých soubojů. Zdaleka vše není rozhodnuto a tak si týmy musí dávat velký pozor, aby někde nezaškobrtly a nepřišly tak o vydobyté pozice. Začneme tentokrát ve středu v 16:00 abychom skončili před startem utkání KC@PIT. Přijďte nás pozdravit živě a třeba, přijde i Ježíšek! --------------------------- OBSAH: 0:00:11 Úvod0:04:26 Vyhlášení soutěže z živého vysílání0:08:17 Noriho informační okénko0:10:00 Ondry "superbowlové" navázání0:11:45 Draft párty trip do Green Bay0:19:18 Steelers vs Chiefs0:27:59 Texans vs Ravens0:38:12 Bears vs Seahawks (TNF, NS1)0:47:07 Patriots vs Chargers (NS6)0:55:42 Bengals vs Broncos (NS6)1:02:26 Rams vs Cardinals (NS2)1:07:25 Bills vs Jets1:11:49 Saints vs Raiders1:19:51 Komerční vložka aneb díků vzdání partnerům projektu NFL.cz1:23:07 Eagles vs Cowboys (NFL.cz derby kola, NS6)1:33:23 Giants vs Colts1:38:09 Buccaneers vs Panthers1:43:12 Jaguars vs Titans1:46:38 Browns vs Dolphins1:50:02 Vikings vs Packers (Telly TV zápas kola, NS6)2:02:06 49ers vs Lions (MNF, NS6)2:07:36 Vyhlášení soutěže Bold Picky s Matty Glamping2:08:58 Commanders vs Falcons (NFL.cz zápas kola, SNF, NS2)2:16:30 Sázkařské okénko s Fortunou

Za pár dní téměř po celém světě zvládne klid a pohoda Vánočních svátků. V NFL je to ale přesně naopak. Teď začíná ta největší bojová vřava o pár míst v play-off. Kdo tenhle závěrečný sprint zvládne nejlépe? Kdo načasuje ideální formu na vyřazovací boje? A kdo naopak už vyhlíží nadcházející draft? To jsou všechno palčivé otázky, které se pokusíme odpovědět v našem tradičním vysílání ve středu od 17:45 na našem Youtube. Jako vždy budeme rádi za každého diváka, který se stihne připojit živě. ---------------------------------------- OBSAH: 0:00:09 Úvod0:00:57 Vyhlášení soutěže z živého vysílání0:02:30 Norbertovo informačné okénko0:05:11 Nový NFL.cz Overtime0:09:58 Chargers vs. Broncos (NFL.cz Derby kola, TNF, NS6)0:25:22 Chiefs vs. Texans (NS6)0:36:08 Falcons vs. Giants0:48:59 Bills vs. Patriots0:57:37 Bears vs. Lions1:03:53 Colts vs. Titans1:11:52 Jets vs. Rams1:16:53 Komerční intermezzo aneb díků vzdání partnerům projektu NFL.cz1:21:03 Commanders vs. Eagles (Telly TV zápas kola, NS6)1:29:55 Panthers vs. Cardinals1:37:10 Bengals vs. Browns1:42:04 Seahawks vs. Vikings1:51:23 Raiders vs. Jaguars1:55:47 Dolphins vs. 49ers (NS6)2:05:22 Cowboys vs. Buccaneers (SNF, NS1)2:13:28 Packers vs. Saints (MNF, NS2)2:22:31 Ravens vs. Steelers (NFL.cz zápas kola, NS6)2:28:21 Sázkařské okénko s Fortunou2:32:32 Kupte si nové NFL.cz tričko na Superbowl párty

Je tady jeden z vrcholů základní části NFL. Už zítra oslaví celé Spojené státy Den díkůvzdání, který slovy jednoho z nejznámějších komentátorů a trenérů spojuje v sobě ty nejkrásnější věci na světě. Přátele, rodinu, jídlo a fotbal. V NFL se říká, že od tohoto data už jde opravdu do tuhého. Nejlepší týmy nastavují formu tak, aby ideálně neprohráli už po celý zbytek roku. Komu se to povede a kdo naopak zůstane před branami vytoužených úspěchů? To vše proberem klasicky ve středu v 17:45 na našem Youtube kanále. Těšíme se na vás a jako vždy připomínáme, že vyhodnocení soutěží proběhne live! ----------------------------------- OBSAH: 0:00:10 Úvod 0:02:17 Vyhlášení soutěže z živého vysílání 0:03:49 Noriho informačné okienko 0:10:53 Lions vs Bears (Telly TV zápas kola, NS1) 0:18:14 Vyhlášení soutěže s Telly TV 0:19:55 Cowboys vs Giants (NS1) 0:29:17 Packers vs Dolphins (NS1) 0:43:23 Chiefs vs Raiders (NS5) 0:49:56 Falcons vs Chargers 0:59:38 Vikings vs Cardinals 1:10:16 Patriots vs Colts 1:15:27 Jets vs Seahawks 1:21:07 Komerční intermezzo aneb poděkování partnerům projektu NFL.cz 1:27:11 Bengals vs Steelers (Derby kola) 1:36:44 Commanders vs Titans 1:44:51 Jaguars vs Texans 1:51:01 Saints vs Rams 2:01:02 Panthers vs Buccaneers 2:07:53 Soutěž Bold Picky s Matty Glamping 2:09:53 Bills vs 49ers (SNF, NS2) 2:19:24 Broncos vs Browns (MNF, NS6) 2:25:44 Ravens vs Eagles (Zápas kola, NS2) 2:34:03 Sázkařské okénko s Fortunou

Polovina základní části sezóny NFL je bohužel za námi. To ale zatím není důvod propadat smutku a panice. Ještě pořád je před námi spoustu zajímavého a napínavého fotbalu. Desátý hrací týden mimo jiné přinese také utkání v Mnichově, ke kterému podobně jako k prvnímu Londýnskému utkání připravujeme obrovské množství obsahu. Budeme samozřejmě také sledovat, jak se uchytí nový hráči, kteří byli vyměněni těsně před trade deadline. Zkrátka a dobře témat na probrání je obrovská spousta, tak přijďte ve středu od 17:45 na náš youtube. ----------------------------------------------- OBSAH: 0:00:09 Úvod0:01:47 Představení nových partnerů NFL.cz0:13:03 Vyhlášení soutěže z živého vysílání0:16:28 Giants vs Panthers (International Game - Mnichov, NS1)0:23:47 Bears vs Patriots0:33:50 Colts vs Bills0:41:08 Chiefs vs Broncos0:51:38 Saints vs Falcons1:03:16 Buccaneers vs 49ers1:11:12 Commanders vs Steelers (NS6)1:18:54 Komerční přestávka - poděkování partnerům projektu NFL.cz1:23:57 Ravens vs Bengals (Derby kola, TNF, NS2)1:33:53 Jaguars vs Vikings1:41:33 Chargers vs Titans1:48:20 Cowboys vs Eagles (NS6)1:56:56 Soutěž Bold Picky s Matty Glamping2:00:29 Cardinals vs Jets2:09:21 Rams vs Dolphins (MNF, NS2)2:17:53 Texans vs Lions (Zápas kola, SNF, NS6)2:29:09 Sázkařské okénko s Fortunou2:32:35 Závěr

Máme za sebou osmý hrací týden a s ním v podstatě celý měsíc říjen. Zároveň se dostáváme do poloviny základní části a výrazným způsobem se přibližujeme k trade deadline, který nastane 5.11. Ještě předtím je ale potřeba odehrát a pochopitelně i rozebrat devátý hrací týden. Jsou Jets definitivně odsouzeni k neúspěchu? Ztratilo se kouzlo Vikings? Zvedají se Eagles? To jsou jen některé otázky, kterým se pokusíme přijít na kloub v našem tradičním vysílání ve středu 30.10. od 17:45 na našem Youtube. Přijďte za námi živě! -------------------------------------- OBSAH: 0:00:09 Úvod0:00:32 Informační okénko - představení Vito Martini Sports Cards0:04:01 Vyhlášení soutěže z živého vysílání0:06:24 Stanovisko k vysílání zápasů NFL na kanálech Nova Sport0:09:24 Jets vs Texans (TNF, NS2)0:17:44 Falcons vs Cowboys (NS1)0:29:32 Bills vs Dolphins0:34:51 Bengals vs Raiders0:39:59 Browns vs Chargers0:45:24 Titans vs Patriots0:56:53 Ravens vs Broncos1:03:39 Reklamní přestávka - poděkování partnerům projektu NFL.cz1:07:08 Seahawks vs Rams (NFL.cz derby kola)1:15:48 Giants vs Commanders1:23:15 Panthers vs Saints1:33:04 Eagles vs Jaguars1:39:31 Cardinals vs Bears1:50:39 Soutěž s Matty Glamping1:56:20 Vikings vs Colts (SNF, NS1)2:04:49 Chiefs vs Buccaneers (MNF, NS6)2:08:37 Packers vs Lions (Zápas kola, NS1)2:16:07 Sázkařské okénko s Fortunou

Ať už tomu chcete věřit, nebo ne, čeká nás šestý hrací týden NFL. Máme za sebou první trenérskou změnu a spousta velkého potenciálu přišla vniveč. Na druhé straně Vikings se poprali i s tradičním britským počasím a stále zůstávají neporaženi. Co nám přinese nadcházející kolo? Udělali Jets správný krok? Dává smysl v tuto chvíli startovat Drakea Mayeho? Jako obvykle vše důležité probereme ve středu od 17:45 na našem YouTube. --------------------------- OBSAH: 0:00:09 Úvod0:01:34 Shrnutí ke speciálnímu předzápasovému studiu k zápasu Vikings vs Jets v Londýně0:04:35 Noriho informační okénko0:07:46 Seahawks vs 49ers (TNF, NS6)0:16:06 Bears vs Jaguars (International game, NS1)0:27:28 Packers vs Cardinals0:33:26 Titans vs Colts0:43:17 Patriots vs Texans0:53:32 Saints vs Buccaneers0:59:27 Eagles vs Browns1:08:41 Poděkování donátorům a partnerům projektu NFL.cz1:10:46 Broncos vs Chargers (NFL.cz derby kola)1:20:05 Ravens vs Commanders (NS1)1:30:54 Raiders vs Steelers1:40:46 Panthers vs Falcons1:51:03 Giants vs Bengals (SNF, NS6)1:58:43 Jets vs Bills (MNF, NS2)2:20:51 Cowboys vs Lions (NS1)2:28:00 Sázkařské okénko s Fortunou

Září už nám pomalu ale jistě zamávalo z rychlíku s nápisem NFL. První měsíc skončil a jako by to bylo včera, co jsme nahrávali předsezonní Studio. Jsou odehrána první čtyři kola a teď už rozhodně není čas na výmluvy. Kdo se vyprofiloval jako překvapivý favorit? Komu věříme formu a kdo naopak půjde dolů? Na to všechno se pokusíme odpovědět v prvním říjnovém vydání našeho pravidelného podcastu. Nalaďte se live ve středu od 17:45 na našem YouTube, protože pro vás máme jednu velkou pecku, která zase posune pokrytí NFL v českých a slovenských televizích! ------------------------ OBSAH: 0:00:09 Úvod0:01:31 Ondrovo informační okénko0:07:32 Live studio z Londýna0:15:16 Vikings vs Jets (NFL.cz zápas kola, International game, NS1)0:33:34 Falcons vs Buccaneers (TNF, NS1)0:44:41 Bears vs Panthers0:55:19 Patriots vs Dolphins1:06:02 Commanders vs Browns1:15:09 Jaguars vs Colts1:21:43 Texans vs Bills (NS1)1:34:19 Poděkování donátorům a partnerům projektu NFL.cz1:36:08 Bengals vs Ravens (NFL.cz derby kola)1:44:17 Broncos vs Raiders1:51:06 49ers vs Cardinals1:58:31 Rams vs Packers (NS1)2:03:56 Seahawks vs Giants2:10:26 Steelers vs Cowboys (SNF, NS1)2:15:10 Chiefs vs Saints (MNF, NS1)2:21:43 Sázkařské okénko s Fortunou

Je to už otřepané klišé, ale minulý týden v NFL byl opravdu naprosto šílený. Favorité prohrávali a outsideři vyhrávali. Pokud někdo trefil více než 50 % zápasů, může se klidně pyšnit titulem tipérského krále. Bude tento trend pokračovat? Podaří se konečně někomu zastavit spanilou jízdu Vikings, kteří přejeli dva obrovské favority? Které divizní souboje nám nejvíce napoví? Všechny důležité otázky jako obvykle zodpovíme ve středu od 17:45 na našem YouTube kanále. ---------------------------------------------------------- 0:00:08 Úvod0:01:21 Noriho informační okénko0:07:16 Giants vs Cowboys (TNF, NS1)0:16:19 Bears vs Rams0:25:57 Packers vs Vikings0:44:11 Colts vs Steelers0:54:42 Jets vs Broncos1:04:04 Buccaneers vs Eagles (NS1)1:14:39 Panthers vs Bengals1:23:24 Texans vs Jaguars1:30:27 Intermezzo aneb poděkování partnerům projektu NFL.cz1:33:42 Falcons vs Saints (Mrzákbowl derby kola)1:43:56 Cardinals vs Commanders1:50:55 49ers vs Patriots2:01:07 Raiders vs Browns2:01:30 Chargers vs Chiefs (NS1)2:13:25 Dolphins vs Titans (MNF)2:16:45 Lions vs Seahawks (MNF, NS1)2:22:42 Ravens vs Bills (SNF, NS1)2:33:39 Sázkařské okénko s Fortunou

I druhé hrací kolo nám uběhlo dříve, než bys řekl touchdown. Pokud byl první hrací víkend ve znamení favoritů, tak v tom druhém se děly věci. Outsideři se vyšvihli na světlo světa a někteří dokonce potvrdili svou dvouzápasovou šňůru. Jak to bude vypadat dál? Oklepe se někdo z prvních dvou porážek? Prospějí některému z týmů změny v sestavě? Na tyto palčivé otázky se pokusíme odpovědět jako vždy ve středu 18. 9. od 17:45. Přijďte si s námi popovídat a nezapomeňte na skvělé Ohlédnutí v podání Laciho a Štigiho na našem instagramu. --------------------------------------- OBSAH: 0:00:10 Úvodní informační okénko0:10:17 Jets vs Patriots (TNF, NS1)0:18:07 Browns vs Giants0:23:50 Titans vs Packers0:37:19 Colts vs Bears0:48:35 Vikings vs Texans (NS1)0:44:17 Saints vs Eagles1:07:20 Steelers vs Chargers1:18:13 Buccaneers vs Broncos1:24:45 Poděkování partnerům projektu NFL.cz1:26:19 Rams vs 49ers (NFL.cz derby kola)1:33:48 Raiders vs Patnhers1:40:30 Seahawks vs Dolphins1:48:00 Cardinals vs Lions1:56:47 Falcons vs Chiefs (SNF, NS1)2:04:47 Bills vs Jaguars (MNF)2:10:14 Bengals vs Commanders (MNF, NS1)2:15:48 Cowboys vs Ravens (NFL.cz zápas kola, NS1)2:23:28 Sázkařské okénko

První kolo je za námi a jako vždy nám přineslo spoustu napínavých a dramatických momentů. Teď už se ale přesouváme do druhého hracího týdne, ve kterém by se favorité měli stabilizovat a dostát papírovým předpokladům. Bude tomu tak, nebo jsme v našich předsezonních analýzách viděli věci jinak, než nakonec jsou? A jak budou vypadat zápasy Weeku 2? To vše se dozvíte 11. 9. od 17:45 v našem tradičním YouTube studiu. Přijďte se na nás podívat živě, protože se vracíme k soutěžení! OBSAH: 0:00:09 Úvod, informační servis a novinky kolem webu NFLcz 0:04:15 Cowboys vs Saints 0:14:13 Lions vs Buccaneers (NS1)0:22:42 Packers vs Colts0:31:45 Titans vs Jets0:43:43 Vikings vs 49ers0:48:23 Patriots vs Seahawks0:53:43 Commanders vs Giants0:58:31 Panthers vs Chargers1:06:09 Dolphins vs Bills (TNF, NS1)1:23:38 Jaguars vs Browns1:31:21 Ravens vs Raiders1:39:29 Cardinals vs Rams1:48:21 Broncos vs Steelers1:54:56 Texans vs Bears (SNF, NS1)2:05:16 Eagles vs Falcons (MNF, NS1)2:15:29 Chiefs vs Bengals (NS1)

V noci ze čtvrtka na pátek nám začíná 105. ročník NFL. Dlouhé čekání na ostré zápasy je u konce a my se do celé záležitosti vrháme opravdu po hlavě. První hrací týden nabídne velkou řadu zajímavých zápasů a skvělých příběhů, včetně speciálního brazilského zápasu, který se odehraje v noci z pátka na sobotu. Celý obrovský kolotoč se roztáčí, ale nebude to nějaký pozvolný rozjezd, ale pořádně plný plyn od prvních chvil! Buďte u toho s námi jako vždy ve středu od 17:45! -------------------------------------- OBSAH: 0:00:10 Úvod, informační servis a novinky kolem vysílání na Nova Sport 0:06:50 Eagles vs Packers (FNF, NS1)0:20:58 Falcons vs Steelers0:32:04 Bills vs Cardinals0:39:44 Bears vs Titans0:52:02 Bengals vs Patriots0:58:00 Dolphins vs Jaguars (NS1)1:06:24 Saints vs Panthers1:16:34 Colts vs Texans1:27:19 Giants vs Vikings1:39:15 Chargers vs Raiders1:48:26 Seahawks vs Broncos1:57:53 Browns vs Cowboys (NS1)2:05:25 Buccaneers vs Commanders2:11:16 Lions vs Rams (SNF, NS1)2:18:09 49ers vs Jets (MNF, NS1)2:25:59 Chiefs vs Ravens (TNF, NS1)

Exames para detectar a dengue estão disponíveis em Unidades Básicas de Saúde (UBS) e em hospitais do Sistema Único de Saúde (SUS).

Astrólogos indicados: Sara - https://www.instagram.com/vibeastral?igsh=MTY1d2sxbTNmZGh0NA== Zeno - https://www.instagram.com/zeno.astropresente?igsh=MWx1bmg1ZTNzejd5dw== Khalil - https://www.instagram.com/itsmekmk?igsh=MXgxcDM5cDBtYWdzNg== Numerologia cabalística: https://www.teledipity.com/ Escrita terapêutica: um caderno que você se sinta a vontade para escrever ou um da Nuvola. Carta para o futuro - Future Me: https://www.futureme.org Mapa maia: https://tzolkin.io/NS1.8.7.20 Jornada do propósito: Instituto Sofia https://www.instagram.com/institutosofia?igsh=MTljcXc2OGo1cnA3cA==

In this episode Andy Hershey, Chief Revenue Officer at NS1, shares his journey and drops gems of wisdom on various aspects of successful teamwork and marketing strategies. We dicuss the critical importance of alignment and collaboration within go-to-market teams, explore the power of cross-functional partnerships and the magic of shared goals, as well as why prioritizing lead quality is paramount--especially in challenging business landscapes. To our listeners, don't forget to hit that subscribe button and leave a review if you found this episode as enlightening as we did. Your feedback is our fuel! Andy Hersheys Linkedin Profile Aligning Goals with Cross-Functional Teams [00:03:19] The importance of building strong partnerships and aligning goals with the CMO, CFO, and CPO for successful scaling. Investing in Relationships and Building Trust [00:05:09] The value of investing in relationships and getting to know team members personally to foster collaboration and effective teamwork. Focus and Alignment for Successful Execution [00:08:15] The significance of having a clear focus and aligned goals to drive execution and achieve desired outcomes. The importance of revenue and focus on pipeline [00:08:57] The speaker discusses the common goal of revenue and the opportunity cost of investing in a new product. Aligning go-to-market teams [00:10:49] The host asks for advice on how to achieve cross-functional alignment within go-to-market teams. Career trajectory and steps to become a revenue leader [00:17:22] The speaker shares the steps he took to transition from an individual contributor to a revenue leader role. The trade-off between quantity and quality of leads [00:18:41] Discussion on the importance of not solely focusing on the quantity of leads, but also considering the quality to maximize closing opportunities. The challenge of managing leads and labeling [00:19:26] Exploration of the age-old question of how to balance the trade-off between quality and quantity when it comes to leads and developing pipeline. Closing remarks and call for guest nominations [00:19:32] Speaker 1 wraps up the conversation, thanks the guest, and encourages listeners to subscribe, rate, review the podcast, and nominate potential guests. Are you happy with the results?

In this episode Ryan Davis, Chief Information Security Officer at NS1, speaks with host Tom Eston about the changing role of the CISO, acquisitions, what the biggest challenges are, and Ryan's advice for those considering a career as a CISO. This is one episode you don't want to miss if you're curious what a CISO […] The post The Changing Role of the CISO with Ryan Davis, Chief Information Security Officer at NS1 appeared first on Shared Security Podcast.

A resolução que atualizou as normas de coleta, exames e análises para o diagnóstico de doenças entrou em vigor nesta terça-feira (1º). Entre as mudanças está a autorização dada a farmácias e consultórios isolados para a realização de exames clínicos em etapa única, com caráter de triagem. Com a mudança, a lista de exames clínicos para triagem passa de mais de 40 tipos, como o do antígeno NS1 para triagem da dengue, por exemplo. Em entrevista à CBN Vitória, o farmacêutico Daniel Marcellos, membro do Grupo Técnico de Trabalho em Farmácia, Empresa: Conselho Regional de Farmácia do Estado do Espírito Santo (CRF-ES), fala sobre a mudança.

A resolução que atualizou as normas de coleta, exames e análises para o diagnóstico de doenças entrou em vigor nesta terça-feira (1º). Entre as mudanças está a autorização dada a farmácias e consultórios isolados para a realização de exames clínicos em etapa única, com caráter de triagem. Com a mudança, a lista de exames clínicos para triagem passa de mais de 40 tipos, como o do antígeno NS1 para triagem da dengue, por exemplo. Em entrevista à CBN Vitória, o farmacêutico Daniel Marcellos, membro do Grupo Técnico de Trabalho em Farmácia, Empresa: Conselho Regional de Farmácia do Estado do Espírito Santo (CRF-ES), fala sobre a mudança.

※ 投稿邮箱：418150505@qq.com※ 本文章首发订阅号：百车全说，订阅号阅读更加方便，欢迎关注。你有没有发现，最近一年里，不光国产新能源的价格越来越卷，就连合资品牌的新能源价格也在慢慢放低身段。就像丰田的bZ4X，之前可是要25万多才能买到中高配，现在19.98万起，据说有的地方还降了6万，只要13.98万起。还有日产日产艾睿雅上个月的湖北大促销也是一下降了6万。但是今天要说的是一款全新车型，前段时间上市的别克E5，定位中大型纯电SUV，售价却只要20.89万起。这个价格一出来网友也是直呼真便宜，有诚意。事实真的如此吗？我们这期节目就来好好聊聊别克E5的价格到底贵不贵？新车都有哪些亮点？适合什么人买，以及配置又该怎么选？别克E5的价格贵不贵？直接说结论，确实很便宜。我就问你一个问题，如果买合资燃油车，你会拿别克对比哪些品牌？无非是大众、丰田、本田 、日产等等。那么，你放眼整个20万的合资纯电SUV市场，看看除了别克E5，还能买到哪些产品？日系你可以看三款：本田e:NS1、丰田bZ4X和日产艾睿雅。本田e:NS1就不用说了，定价17.5-21.8万，花20万就买个XR-V的油改电，还是个小型SUV，确实就是妥妥的韭菜。估计绝大多数人也压根都没听过这台车。本田都不愿意给这车做广告，完全是来打酱油的。丰田bZ4X定位中型SUV，但是车长还不足4米7，轴距2850毫米，起售价19.98万起。其实一开始bZ4X的售价非常贵，都要去到25万才能买到中配。最近迫于库存压力和内卷的大环境，才开始大幅降价，指导价降到了19.98万。但是听说最近这个售价又降到了13.98万。之所以这车即便降价也无人问津，大概率因为三点。丰田过于相信自己的品牌力，还是按照燃油车的思路销售，价高配低，电动车准用户不吃这一套。其次，有车主反映在0-4摄氏度的条件下，bZ4X的续航达成率只有约48%。作为参考，同样参与测试的特斯拉Model Y四驱版本的续航达成率为近七成，而奔驰EQA和大众ID.4也有六成以上的表现。同时，在低温环境下快充速度慢，也被众多车主吐槽。日产艾睿雅也是自恃清高的主，一个紧凑级纯电SUV定价却要28.48万起，车长才4米6出头，轴距2米8都没有，价格真的是虚高太多了。如果艾睿雅能有目前bZ4X的降价幅度，我猜销量应该会上来。因为同是日系纯电SUV，它可比bZ4X好看多了。并且，日产是真的在纯电技术上有积累，日产Leaf曾经常年位居全球电动车销量榜第一的位置，只不过中国消费者大多不知道而已。再看德系这边，大众的ID系列虽然定价高，但是人家早早地就把优惠放开了。比如ID.4系列虽然定价19万多起，但是ID.4中低配优惠完落地都在16万左右甚至更低，所以它的销量也不小。现在上汽大众ID.4 X加一汽大众ID.4 CROZZ一起每个月也有4000多台，在合资里绝对算卖得好的。但是ID系列里也只有ID.3和ID.4卖得好，同样是中大型SUV的ID.6优惠就很少，落地基本都要25万+，销量自然也不会太好。现在咱们再回头看看，合资品牌中大型SUV的别克E5，长宽高为4892/1905/1684毫米，轴距2954毫米。和日系比，那肯定是大了两圈都不止，即便对比德系ID.6 X，车长还长了16毫米，但是轴距也短了11毫米。而ID.6 X是7座，别克E5是五座，有点类似汉兰达与冠道的竞争关系。E5和ID.6 X比，E5属于是大两房，ID.6 X是小三房。更重要是E5比ID.6 X的起售价要便宜了五万。说完了合资，咱甚至可以对比国产，别克E5的尺寸也确实很能打。就比如一向以性价比著称的比亚迪，20万的纯电SUV你也只能买到宋PLUS EV。就算你再加上混动，也只能买买唐DM-i和护卫舰07。而唐EV的起售价也要去到28万多了。并且对比唐的尺寸，E5车长比它长了22毫米，轴距更是长了134毫米，而且唐还不是比亚迪最新的e3.0纯电平台，E5是通用最新的奥特能纯电平台。说句不该说的，别克E5甚至比自家燃油车定价还便宜，真的是别克狠起来连自己都打。先来看看花20万能买到哪些别克燃油SUV？昂科威S 定价20.99万起，昂科威PLUS定价22.59万起，这两车都比E5小不少。更夸张的是别克E5的尺寸都已经和29.99万起的昂科旗非常接近了。E5的车长比昂科旗短了99毫米，但是轴距却比昂科旗长了91毫米。所以理论上说，E5的车内空间基本和昂科旗差不多，但是售价却便宜了9万。即便优惠完，昂科旗的落地价也是要比E5高好几万，这还没算上E5有着更好的内饰设计以及更丰富的功能配置。此外，别克E5的同门师哥凯迪拉克锐歌，售价都要43.97万起，它俩可是出自同一平台，都是中大型SUV，只不过单电机版一个后驱，一个前驱。但是别克E5却比锐歌便宜了整整一半的价格，你说这个价格让以后的凯迪拉克锐歌还怎么卖？一个凯迪拉克标值20万吗？不过这也是玩笑话，锐歌的用料、质感以及外形设计肯定也要比E5强不少。但是网友都调侃， 别克E5就是凯迪拉克锐歌“青春版”，我觉得还挺贴切的。因此一句话总结别克E5，20万的定价，30万的尺寸。即使目前没有优惠，也有一定的性价比。别克E5有哪些亮点？既然说它的定价很良心，那它究竟有哪些亮点？第一，肯定是尺寸和空间。这个就不用多说了，刚才说的已经很透彻了。20万出头，基本没有比它尺寸还大的合资纯电SUV了，国产品牌也屈指可数。第二，和凯迪拉克锐歌一样，用的都是通用最新的奥特能纯电平台。这个平台有两大亮点，一是对电池的安全性确实下了不少功夫。直接说结果，奥特能平台的电池经过了很多测试，比如将电池包从5米的高空坠落，没起火也没冒烟，并且电池模组和冷却液管都完好。这个国家标准是1米。奥特能在诞生初期，通用内部的标准比国标还要高得多。而且电池壳体使用超高强度的钢井字形结构，大幅优化了电池的碰撞防护性能。其次，这个平台在智能化上也有创新。比如无线连接的电池管理系统（wBMS）。据说这个创新在布局上可以减少90%线束，以此来提升电池组的安全性。不过我觉得这个平台最大的特点就是下到20多万的别克E5，上到凯迪拉克锐歌，以及海外一千多匹马力的全新悍马EV，用的都是奥特能。所以不严谨的说一句，别克E5和悍马EV也是远房兄弟。第三，E5起步就是高配。要说别克E5内饰最大的亮点，一定是中控台上这块30英寸的一体式弧面6K屏幕。好像自从福特EVOS开始，美系车终于把内饰设计给重视起来了，之前屏幕要么不舍得给，要么杵着个竖屏。但是从福特的带鱼屏再到别克E5的曲面屏，不得不说，只要认真对待消费者的需求，就不会设计不出好看的内饰。E5上的这块30英寸的屏幕其实已经很大了，而且中间没有大黑框风格，看起来就是一整块。不过，锐歌的33英寸屏幕更大。但是E5的定价只有锐歌的一半，屏幕尺寸小了3英寸，可以理解吧。更关键的是，这块屏E5是全系标配。除了屏幕以外，像方向盘加热、百度地图、VCS智能座舱、全新eConnect系统、高通骁龙8155芯片、eCruise Pro智能驾驶辅助等也都是全系标配。是不是挺良心的？配置怎么选？目前别克E5售价20.89-27.89万，有五个配置，标准续航和长续航各有低配和高配，再加一个四驱艾维亚顶配。不过主流的四个单电机配置价格都在23.99万以下。但就像刚才说，别克E5入门即高配，所以如果你对续航没有要求，那么最低配的智享标准续航版就是最有性价比的配置，毕竟三元锂电池也有68度，CLTC续航545公里，日常也是完全够用的。并且两个标准续航的电机马力也要更大，标准续航的单电机最大马力245匹，最大扭矩330牛·米，售价20.89万。长续航的电机最大马力204匹，330牛·米，电池包也从68度涨到了80度，CLTC续航620公里，定价22.29万。因此最低配这2个配置最值得推荐。如果你觉得预算还没花完，那可以看看23.99万的臻享长续航。配置上还多了20英寸轮圈、电动后备箱+记忆、开门预警、360全景影像、泊车入位、真皮座椅+座椅通风、121色氛围灯等。至于艾维亚的四驱版，我觉得就没有必要了。虽然它是四驱双电机，但是系统最大马力287匹，，百公里加速6.7秒。但是放眼整个市场，27.89万的定价显得性价比不是那么高，毕竟25-30万可选的电动车可以太多了，而且很多都是三秒俱乐部成员。所以真正推荐入手，要么最低配，要么长续航的高配。别克E5适合什么人买？和自家的兄弟又该怎么选？20万这个价位能买的电车已经非常多了，有像smart精灵1号、极氪X这样的精品小车，也有像比亚迪汉EV、深蓝SL03这样的高性价比中型、中大型轿车，还有深蓝S7、小鹏G6、比亚迪宋PLUSEV等一众国产纯电SUV。但是20万想买台纯电SUV，还要合资，可选的真不多。所以别克E5的受众群体就很明显了，在这个价位，不仅想要一台空间大的纯电SUV，且更青睐合资品牌，那别克E5确实是个不错的选择。至于和自家兄弟E4怎么选，其实也很简单。别克E4新车最大的亮点就在它的外观设计。其实我也没想到，作为一款合资的纯电车，做得确实还挺好看。虽然前脸和E5差不多，但是侧面和车尾和E5完全就是两台车了，一个是正常的SUV造型，一个是溜背造型。并且车尾还有两个尾翼设计，看起来确实很动感，这个设计年轻人肯定喜欢。而且内饰标配的30寸曲面屏也是亮点之一。所以E4和E5最大的区别就在外观，E4更像是E5的轿跑版。另一个亮点肯定是它的空间和尺寸了，E4长宽高为4818/1912/1580毫米，轴距2954毫米。长度比E5短了74毫米，宽度相差7毫米，高度矮了101毫米，所以E4的造型更低趴一些。其他地方E4和E5基本就一样，不管是30寸的6K曲面屏还是方向盘，基本没区别。而且再到动力和续航，差别也不大，标准续航版搭载65度的弗迪磷酸铁锂电池，CLTC续航530公里，顶配的长续航四驱搭载79.7度的时代上汽三元锂电池，CLTC续航620公里。此外，E4最大的亮点还在于结合了GS套件。因为E4的定位明显要更年轻，所以比起E5，E4加入了GS的运动套件。不过GS在E4上就是个皮肤，类似宝马的M套件、奥迪的S-LINE等。但是有了这套运动皮肤的加持，E4确实要更有吸引力。所以综合来说，别克E4的消费者肯定要比E5更加的年轻化，而且更加追求整车的颜值和设计。写在最后不过，虽然别克E5的性价比很高，亮点也很多，但是不足之处依然有。比如在造型上，还是有些油车的影子。而且别克E5的动力比较保守，连四驱双电机的百公里加速也只有6.7秒。当然话分两头讲，照顾续航，就得牺牲动力，这是取舍问题。其次，虽然E5智能化速度还不够快。比如，如果你选装高阶智能驾驶辅助Super Cruise，暂时还不能用，得等到年中才能开放使用。而目前市面上能实现NCA城市智能驾驶的车都已经有很多款了。而且，现如今的消费者在买电车时，消费观念也已经很明确，很大一部分消费者在买车前，就清楚自己不仅仅是在买一台电车，更多的是在买一种全新的消费体验，想要花相同的价格来体验到同价位油车所没有的功能和服务。如果以这种眼光来看别克E5的话，别克E5更多的是一台空间很大、性价比很高的工具电车。车内功能很全，但是没有那种眼前一亮的感觉。而在未来的车主服务方面，别克E5不是独立一套服务体系，还是依托原有的燃油车经销商，这也是需要选择的难题。但无论怎么说，E5这个产品看得出是给出很大诚意了，后续再努努力，说不定别克在合资纯电市场还真能闯出一番天地。作者：三刀、新一编辑：新一可以添加微信46415254加入我们的社群音频图文更新在订阅号： 百车全说每期抽三条留言，每人赠168元的“芥末绿”燃油添加剂一瓶点击订阅，每周三，周六更新会有提醒新听友可以搜索：百车全说2014，百车全说2015，百车全说2016，往期300多个小时的节目可供收听

This week's Network Break discusses NetBox Labs's $20 million funding round and why it spun itself out of NS1's IBM acquisition, Intel Foundry and Arm teaming up on SoC manufacturing, why Amazon sees headwinds for public cloud spending (and why the opportunity is still huge), how the juice-jacking threat got hyped, and more tech news.

This week's Network Break discusses NetBox Labs's $20 million funding round and why it spun itself out of NS1's IBM acquisition, Intel Foundry and Arm teaming up on SoC manufacturing, why Amazon sees headwinds for public cloud spending (and why the opportunity is still huge), how the juice-jacking threat got hyped, and more tech news. The post Network Break 426: NetBox Labs Raises $20 Million; Intel Foundry, Arm Team Up To Make SoCs appeared first on Packet Pushers.

This week's Network Break discusses NetBox Labs's $20 million funding round and why it spun itself out of NS1's IBM acquisition, Intel Foundry and Arm teaming up on SoC manufacturing, why Amazon sees headwinds for public cloud spending (and why the opportunity is still huge), how the juice-jacking threat got hyped, and more tech news.

This week's Network Break discusses NetBox Labs's $20 million funding round and why it spun itself out of NS1's IBM acquisition, Intel Foundry and Arm teaming up on SoC manufacturing, why Amazon sees headwinds for public cloud spending (and why the opportunity is still huge), how the juice-jacking threat got hyped, and more tech news. The post Network Break 426: NetBox Labs Raises $20 Million; Intel Foundry, Arm Team Up To Make SoCs appeared first on Packet Pushers.

This week's Network Break discusses NetBox Labs's $20 million funding round and why it spun itself out of NS1's IBM acquisition, Intel Foundry and Arm teaming up on SoC manufacturing, why Amazon sees headwinds for public cloud spending (and why the opportunity is still huge), how the juice-jacking threat got hyped, and more tech news.

This week's Network Break discusses NetBox Labs's $20 million funding round and why it spun itself out of NS1's IBM acquisition, Intel Foundry and Arm teaming up on SoC manufacturing, why Amazon sees headwinds for public cloud spending (and why the opportunity is still huge), how the juice-jacking threat got hyped, and more tech news. The post Network Break 426: NetBox Labs Raises $20 Million; Intel Foundry, Arm Team Up To Make SoCs appeared first on Packet Pushers.

Das Kriegsgebiet ist nicht nur Land, Luft, Wasser, sondern auch der Informationsraum. Werfen wir einen Blick auf die Methoden der professionellen Desinformation: Strategem 6, Spin, Partial Hangout, Burying. Mehr ansehen für zusätzliche Information. Die 36 Strategeme der Krise (die Kindle-Version ist übrigens gerade im Amazon-Sonderangebot und kostet derzeit nur 4,99 Euro): Kindle: https://www.amazon.de/exec/obidos/ASI... Print: https://www.amazon.de/exec/obidos/ASI... Seymour Hersh “Die USA waren es“: https://seymourhersh.substack.com/p/h... Gegenargumente: https://oalexanderdk.substack.com/p/b... Faktenchecker in Pflanzenform: https://www.tichyseinblick.de/daili-e... Versicherung der Pipeline: https://www.handelszeitung.ch/insuran... SMS aus England: https://www.bbc.com/news/uk-politics-... Angeblicher Durchbruch bei den Ermittlungen: https://www.tagesschau.de/investigati... Wüste Theorie, dass Nordstream 2 ein Unfall war und NS1 dann angehängt wurde: https://oalexanderdk.substack.com/p/i... Weitere Informationen vom Team Rieck: In der Nacht vom 25. zum 26. September 2022 wurde ein Druckverlust im Strang A von Nord Stream 2 gemeldet, später auch in beiden Strängen von Nord Stream 1. Die Ursache war eine Reihe von Explosionen, die seismographisch aufgezeichnet wurden. Um 02'03 Uhr verursachte die erste Explosion ein Leck in Strang A von Nord Stream 2, etwa 12 Seemeilen südöstlich der dänischen Insel Bornholm. Am selben Tag um 19'03 Uhr entstanden mindestens drei weitere Lecks zwischen Bornholm und Öland, von denen zwei in den Strängen von Nord Stream 1 liegen und das dritte erneut Strang A von Nord Stream 2 betraf. Das letzte Leck wurde erst am 29. September 2022 von der schwedischen Küstenwache entdeckt. Der Strang B von Nord Stream 2 blieb unbeschädigt. Die Lecks befinden sich in 70-80 Metern Tiefe und in einem Abstand von mindestens einer Seemeile voneinander. An der Wasseroberfläche waren Gasblasen zu sehen, die im Umkreis von einem Kilometer über den Lecks aufstiegen. Die Lecks liegen knapp außerhalb der Hoheitsgewässer in den ausschließlichen Wirtschaftszonen Dänemarks und Schwedens. Desinformationstechniken können eine ernsthafte Bedrohung für die Demokratie und die Gesellschaft als Ganzes darstellen, da sie dazu führen können, dass Menschen falsche oder irreführende Informationen glauben. Desinformationen beinhalten z.B. falsche Informationen, Manipulation von Suchmaschinen, Cyberangriffe, Deepfakes und das Verbreiten einzelner bis hin zu Trollfabriken. 02'23 Wehrtechnik-Experte analysiert Drohnen-Bilder der Pipeline-Sprengung • Wehrtechnik-Exper... 03'05 Warum Täter ihre Papiere am Tatort „vergessen“ ist immer ein gern besprochenes Thema. Es könnte folgende Gründe für diese Auffälligkeit geben, wie z.B.: 1. Hektik, schlechte Planung, Unfähigkeit 2. Narzissmus und „Heldenkult“ 3. Rationale Erwägungen 4. Falsche Fährten 07'25 Was können Investoren von einem Poker-Profi lernen? • Was können Invest... 10'13 Nordstream Pipeline-Anschlag: Wer war es? (Spieltheorie) • Nordstream Pipeli... 13'07 Strategem 06 (Spieltheorie): Im Osten lärmen, im Westen angreifen • Strategem 06 (Spi... 14'19 Ein Spin bezieht sich auf die Praxis, die Art und Weise, wie Informationen präsentiert werden, zu beeinflussen, um ein bestimmtes Narrativ oder eine bestimmte Perspektive zu fördern. Das Ziel des Spins besteht darin, eine Geschichte oder eine Situation aus einer bestimmten Perspektive darzustellen und dabei bestimmte Aspekte zu betonen oder zu minimieren, um die Wahrnehmung der Menschen zu beeinflussen. 16'42 Ein "Partial Hangout" ist eine Taktik, die in den Bereichen Medienbeziehungen, Wahrnehmungsmanagement, Politik und Informationsmanagement angewendet wird. Die Taktik stammt ursprünglich aus dem Spionagegeschäft. https://en.wikipedia.org/wiki/Limited... 29'20 In der Diplomatie kann Disinformation verwendet werden, um den Ruf anderer Staaten zu schädigen oder eine bestimmte Agenda durchzusetzen. Es kann auch verwendet werden, um Konflikte oder Spannungen zwischen Staaten zu schüren oder um Verhandlungen und Entscheidungsprozesse zu beeinflussen. Weiteres von Christian Rieck: *Digni-Geld - Einkommen in den Zeiten der Roboter: print: http://www.amazon.de/exec/obidos/ASIN... Ebook: http://www.amazon.de/exec/obidos/ASIN... YouTube: https://www.youtube.com/c/ProfRieck?s... Instagram: https://www.instagram.com/profrieck/ Twitter: https://twitter.com/ProfRieck LinkedIn: https://www.linkedin.com/in/profrieck/ *Hinweis: Die angegebenen Links können Affiliate-Links sein, bei denen ich eine Provision bekomme. Vielen Dank, falls Sie diese Links nutzen!

Das Kriegsgebiet ist nicht nur Land, Luft, Wasser, sondern auch der Informationsraum. Werfen wir einen Blick auf die Methoden der professionellen Desinformation: Strategem 6, Spin, Partial Hangout, Burying. Mehr ansehen für zusätzliche Information. Die 36 Strategeme der Krise (die Kindle-Version ist übrigens gerade im Amazon-Sonderangebot und kostet derzeit nur 4,99 Euro): Kindle: https://www.amazon.de/exec/obidos/ASI... Print: https://www.amazon.de/exec/obidos/ASI... Seymour Hersh “Die USA waren es“: https://seymourhersh.substack.com/p/h... Gegenargumente: https://oalexanderdk.substack.com/p/b... Faktenchecker in Pflanzenform: https://www.tichyseinblick.de/daili-e... Versicherung der Pipeline: https://www.handelszeitung.ch/insuran... SMS aus England: https://www.bbc.com/news/uk-politics-... Angeblicher Durchbruch bei den Ermittlungen: https://www.tagesschau.de/investigati... Wüste Theorie, dass Nordstream 2 ein Unfall war und NS1 dann angehängt wurde: https://oalexanderdk.substack.com/p/i... Weitere Informationen vom Team Rieck: In der Nacht vom 25. zum 26. September 2022 wurde ein Druckverlust im Strang A von Nord Stream 2 gemeldet, später auch in beiden Strängen von Nord Stream 1. Die Ursache war eine Reihe von Explosionen, die seismographisch aufgezeichnet wurden. Um 02'03 Uhr verursachte die erste Explosion ein Leck in Strang A von Nord Stream 2, etwa 12 Seemeilen südöstlich der dänischen Insel Bornholm. Am selben Tag um 19'03 Uhr entstanden mindestens drei weitere Lecks zwischen Bornholm und Öland, von denen zwei in den Strängen von Nord Stream 1 liegen und das dritte erneut Strang A von Nord Stream 2 betraf. Das letzte Leck wurde erst am 29. September 2022 von der schwedischen Küstenwache entdeckt. Der Strang B von Nord Stream 2 blieb unbeschädigt. Die Lecks befinden sich in 70-80 Metern Tiefe und in einem Abstand von mindestens einer Seemeile voneinander. An der Wasseroberfläche waren Gasblasen zu sehen, die im Umkreis von einem Kilometer über den Lecks aufstiegen. Die Lecks liegen knapp außerhalb der Hoheitsgewässer in den ausschließlichen Wirtschaftszonen Dänemarks und Schwedens. Desinformationstechniken können eine ernsthafte Bedrohung für die Demokratie und die Gesellschaft als Ganzes darstellen, da sie dazu führen können, dass Menschen falsche oder irreführende Informationen glauben. Desinformationen beinhalten z.B. falsche Informationen, Manipulation von Suchmaschinen, Cyberangriffe, Deepfakes und das Verbreiten einzelner bis hin zu Trollfabriken. 02'23 Wehrtechnik-Experte analysiert Drohnen-Bilder der Pipeline-Sprengung • Wehrtechnik-Exper... 03'05 Warum Täter ihre Papiere am Tatort „vergessen“ ist immer ein gern besprochenes Thema. Es könnte folgende Gründe für diese Auffälligkeit geben, wie z.B.: 1. Hektik, schlechte Planung, Unfähigkeit 2. Narzissmus und „Heldenkult“ 3. Rationale Erwägungen 4. Falsche Fährten 07'25 Was können Investoren von einem Poker-Profi lernen? • Was können Invest... 10'13 Nordstream Pipeline-Anschlag: Wer war es? (Spieltheorie) • Nordstream Pipeli... 13'07 Strategem 06 (Spieltheorie): Im Osten lärmen, im Westen angreifen • Strategem 06 (Spi... 14'19 Ein Spin bezieht sich auf die Praxis, die Art und Weise, wie Informationen präsentiert werden, zu beeinflussen, um ein bestimmtes Narrativ oder eine bestimmte Perspektive zu fördern. Das Ziel des Spins besteht darin, eine Geschichte oder eine Situation aus einer bestimmten Perspektive darzustellen und dabei bestimmte Aspekte zu betonen oder zu minimieren, um die Wahrnehmung der Menschen zu beeinflussen. 16'42 Ein "Partial Hangout" ist eine Taktik, die in den Bereichen Medienbeziehungen, Wahrnehmungsmanagement, Politik und Informationsmanagement angewendet wird. Die Taktik stammt ursprünglich aus dem Spionagegeschäft. https://en.wikipedia.org/wiki/Limited... 29'20 In der Diplomatie kann Disinformation verwendet werden, um den Ruf anderer Staaten zu schädigen oder eine bestimmte Agenda durchzusetzen. Es kann auch verwendet werden, um Konflikte oder Spannungen zwischen Staaten zu schüren oder um Verhandlungen und Entscheidungsprozesse zu beeinflussen. Weiteres von Christian Rieck: *Digni-Geld - Einkommen in den Zeiten der Roboter: print: http://www.amazon.de/exec/obidos/ASIN... Ebook: http://www.amazon.de/exec/obidos/ASIN... YouTube: https://www.youtube.com/c/ProfRieck?s... Instagram: https://www.instagram.com/profrieck/ Twitter: https://twitter.com/ProfRieck LinkedIn: https://www.linkedin.com/in/profrieck/ *Hinweis: Die angegebenen Links können Affiliate-Links sein, bei denen ich eine Provision bekomme. Vielen Dank, falls Sie diese Links nutzen!

Cloud may be the new center of gravity, but the edge really does change everything: architecture, assumptions, workloads, and possibilities. You name it, and edge computing affects the end-to-end workflow of modern business. How can your company take advantage of this exciting new frontier? Check out this episode of DM Radio to find out! Host @eric_kavanagh will interview several guests, including Kris Beevers of NS1, Tony Craythorne of Zadara, and Saimon Michelson of CTERA. They discuss how to deal with the constraints faced by customers out on the edge, the right way to handle moving data, and how AI technology transforms the current business landscape.

Kris Beevers, founder, and CEO of NS1 joins me on Tech Talks Daily. I learn more about how this New York City-based startup delivers smart network control across core network services for over 800 global customers, including Dropbox, Fox, Salesforce, LinkedIn, & eBay. We also talk about the tech startup story behind their success which began as a specialist in DNS, and to quote TechCrunch, took: ‘a slumbering and dreary yet reliable aspect of the Internet and turned it into a strategic moat and an enterprise win'. Kris is a recognized authority on all things DNS, but he also knows a lot about building and deploying high-performance infrastructure globally. He has a Ph.D. in Computer Science. We discuss the impact of outages (including in the summer heatwave) and the importance of multi-cloud or multi-CDNs. We also talk about DDoS attacks, the importance of working with the open source community.

Kontrofensywa Ukrainy, orędzie Władimira Putina, rosyjskie groźby użycia broni atomowej, niepokojące ruchy na terenie Białorusi, wybuchy i wycieki z NS1 i NS2 - o tym wszystkim w najnowszym odcinku Miesięcznika Zagranicznego Nowej Konfederacji! Udział w dyskusji biorą: Jerzy Marek Nowakowski, Marek Budzisz, Bartłomiej Radziejewski. W roli prowadzącej red. Jaśmina Nowak.

ORN Patrick Timpone show notes 9/28/22 Scheduled guest Martin Armstrong is now evacuating his home in Florida due to Hurricane Ian. The lucrative banking industry - making money by making money for a living. Imminent banking crisis starting in Europe and then spreading to the US next year. Sovereign debt crisis will explode in Europe. Promoted by the obsoletes, Patrick's new term for the elites. Too Big To Fail movie about banking-caused 2007 implosion covered over by TARP. It was not caused by subprime mortgages. Long US history of banks running things and causing turmoil. Is this the big one, the one the crashaholics have long warned is coming? Spiritual and emotional shifts going on. Communism, gender confusion, transhumanism, climate change, COVID - It's all been a lie. Is the CIA or another US agency behind the Monday's Nordstream 1 and 2 explosions? They're trying to make everything worse. NS1 and NS2 pipelines are very deep in the ocean. Sabotage probably required a submarine. Charles Nenner doesn't recommend being in equity markets until October or November. Dollar still very strong because other currencies are in worse shape. Dollar Index won't go much higher. Don't give energy to physical complaints. What we resist persists. Patrick's pain in the bladder area went away 2 months after being on an animal based diet. Temps staying up without thyroid now. Is meat the species appropriate diet for humans? The technology of X3. Building muscle with bands- the safest, quickest way to build muscle without getting sore. Never losing pressure is key. Different technology than lifting weights. Repetitively stretching a band with ever decreasing excursions until you can't move. What will currency change to? Choosing not to participate in what's coming. Hurricane Ian - catastrophic strike this am at west coast of Florida, but winds will expand to the east coast of FL. 2nd landing to come on s.e. coast of Florida on Friday. Listener trying to go carnivore, but overwhelming sugar urges on 3rd day. Drinking orange juice to satisfy those cravings. The more sugar you do, the more you want it. Listener's mother suffering with colorectal cancer. In pain and is wasting away. Try bone broth, meat, and fat. Listener not sure they can live without baked potato and pasta. They are comfort foods and wind up being a drug. Compare the feeling after eating pasta to after eating meat. Listener misses Richard Maybury shows. He's taking a break. Stanley Druckmiller – predicts hard landing by end of 2023. Coming recession or worse. Every Fed hiking cycle ends in default and bankruptcy of government. Massive QE of $30 trillion is fueling the recession. We're in deep trouble. Most severe Fed tightening since 1980. The Fed is causing the issues and they know it. Raising increase rates won't stop inflation. 11 year lows on home sales. Will the US be the Weimar Republic or Venezuela? Martin Armstrong found documents showing plans made during Clinton Administration to overthrow Russia. 2 more days on Surthrival Chaga/Reisha 20% off sale.

Pastors must address the news, otherwise the world will set the narrative. Two examples: Alex Jones, and the NS1/2 pipelines. Jesus accused of being a "Conspiracy theorist." The purpose of the preacher is to set the narrative and define the issues, not to react to how the world frames the issues.   The growing "difficulties" are an answer to generations of prayer -- God is forcing His People to make hard choices.  Pastors: lead them!

Cloud may be the new center of gravity, but the edge really does change everything: architecture, assumptions, workloads, possibilites. You name it; edge computing affects the end-to-end workflow of modern business. How can your company take advantage of this exciting new frontier?   Check out this episode of DM Radio to find out! Host @eric_kavanagh will interview several guests, including Kris Beevers of NS1, Tony Craythorne of Zadara, and Saimon Michelson of CTERA.  

Niniejsza audycja rozpoczyna cykl, przygotowywany wspólnie z podcastem Dobry Poziom Dźwięku W tym odcinku Dariusz Marchewka prezentuje trzy wtyczki znanego producenta oprogramowania, oraz sprzętu audio Waves: Narzędzie do redukcji szumu NS1, kompressora One Knob Louder, którym możemy wyrównać poziom naszego sygnału, oraz One Knob Pressure. Trzecia wtyczka to również kompresor, ale przydaje się on wtedy, kiedy potrzebujemy bardziej słyszalnej ingerencji w dźwięk, soczystego brzmienia przy bardzo prostej obsłudze, bez skomplikowanych ustawień.

In this week's Resonance energy market podcast Jeremy Nicholson talks to Alfa's Jason Durden about UK energy markets and pricing, as gas prices reached 11 times higher than a year ago.Topics explored include:The simple truth is there is too much demand and not enough supply.Wholesale gas reaches levels 11 times higher and electricity 9 x higher than 12 months ago.There's a limit to what can be done on supplies.Germany remarks that NS1 coming back in any meaningful way is a pipedream.Will September see a relief to the vacuum of pricing over the holiday season?

In this week's Resonance energy market podcast Jeremy Nicholson talks to Alfa's Dr Petra Puskarova about European energy prices, as Russia announces fresh short-term maintenance on NS1 and the market reacts.Topics discussed include:Markets are through the roof following unplanned maintenance of NS1What might happen to prices if NS1 gas flows return80% gas storage levels across Europe are still expected to be metCarbon tested highs in early August, but is now retracing due to lower industry demandGerman industry at risk due to lower gas supply as minister questions relieving sanctions

In this week's Resonance energy market podcast, recorded on 20th July, Jeremy Nicholson talks to Alfa's Jason Durden about UK energy prices, as the market mulls NS1's awaited return and gas demands from Europe. Topics explored include:NS1 down for maintenance as markets ponder if flows will return this weekUK awash with gas as we export to Europe with it's target to meet 80% storage capacity ahead of winter in perilEDF expected to return to 100% state ownership as France makes the first move of European nations to do soThe most difficult winter since deregulation ahead as we consume more gas and even coal in summer to underpin power generationOil still rangebound in price moves with the real challenge being in refining enough product

Kris Beevers who is the founder and CEO of NS1. This week we get into of course, what NS1 is and if you know… you know, we speak about the history of the internet and how NS1 came to be, the problems that the internet had that NS1 solves, cat pictures, leadership and how Kris developed his leadership skills, the future of NS1, how to build a great experience.That Tech Show Live: https://show.us18.list-manage.com/subscribe?u=ef17b72a23240c06f1a48f203&id=77b17749f8Namcheap Affiliate Link (discounts using the link): https://namecheap.pxf.io/c/3510278/386170/5618Support the show and Buy us a coffee!Edited by: Simon HoernerProduced by: Samuel Gregory and Chris AddamsTheme Music by: Chris AddamsSponsored by: Jupiter and the GiraffeWebsite: https://thattech.showYouTube: https://www.youtube.com/channel/UC4paazkqrlwtB_WW28w4GsgInstagram: @thattechshow_Twitter: @thattechshow_LinkedIn: linkedin.com/company/thattechshow/Get in touch: hello@thattech.show Hosted on Acast. See acast.com/privacy for more information.

Harry Green had the pleasure of being joined by Jordan Villarreal, the Technical Advocate at NS1 in today's episode of the Route to Networking podcast. Jordan highlights the importance of getting hands-on experience to help you learn and progress in your career, he talks about his route into the industry and his recommendations. In such a demanding industry, Jordan discusses the importance of being able to spot burnout, as well as advice on how to handle it if you find yourself or a friend in that situation. Learn more from Jordan:https://www.linkedin.com/in/jordanvillarreal/

On this episode of Innovations in Leadership Kristen interviews Evan Rich, the VP of Operations & Global Services at NS1. They'll talk about how to scale a customer success program, AI integration and Evan's work with companies like paceapp.com.Don't forget to subscribe to stay up-to-date with Innovations in Leadership!

We talk with Eva Ogire, a graduate student in PIMIT at the University of the Reunion on La Reunion Island and CIRI at the University of Lyon, France, who studies the role of the non-structural protein 1 (NS1) in the pathology of epidemic strains of Dengue virus.

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本文章发布于订阅号：百车全说，订阅号阅读更加方便，欢迎关注前37分钟聊丰田bZ4X，后半部分聊五一假期小故事。今天这期节目聊聊前不久刚刚预售的丰田bZ4X。由于刚开始预售，网络上软文太多，很多网友看得晕头转向，甚至有些都已经蠢蠢欲动准备下单了。但是看了看钱包，发现30万买台丰田的电动车，总感觉哪里不对。所以后台收到很多人私信，问我这车到底好不好，能不能买？我先说结论，如果你不差钱，信丰田，想玩个新鲜，可以买。但是你要谈性价比，谈科技感，谈娱乐和舒适性配置，市面上大把的车可以把它虐成渣渣。今天这期节目，我们就详细聊聊这款丰田bZ4X，与大家分享一些我的观点。现如今，买电动车的车主也是越来越挑剔了，因为中国应该是目前世界上可以选择的电动车品牌最多的国家。20-30w这个区间，我们也可以找到几十款电动车可以买。特斯拉的Model3、蔚来的ET5、小鹏P5/P7/G3、比亚迪汉/唐还有后续的一系列海洋系列，其他的像是吉利、奇瑞、长城、广汽埃安等等品牌，一堆的电动车躺着被你选，你为什么一定要买丰田bZ4X呢？是这台车长得太帅，让你无法自拔吗？这台车的整体造型设计，与丰田家族传统燃油SUV相比，并没有特别突出的亮点。反倒是前轮上方的两个黑色轮眉格外醒目。按道理说，你要突出越野车的狂放不羁气质，做个撞色处理我也能够理解。可是那两坨不规则的黑色轮眉设计，就像是涂口红涂歪了的感觉，或者说像是侧面的保险杠还没有喷漆就出厂的感觉。我看了一下玫瑰棕，魅力银都是这样两坨黑色在前轮上方，我是无法接受，不知道大家什么感觉。如果你非要送我一辆bZ4X，我会毫不犹豫地选择墨渊黑，用车身的黑色去遮盖这两坨黑色的轮眉。这台车的内饰设计，也没什么出彩的地方。对外展示的都是7英寸全液晶仪表+12.3英寸中控屏的版本。实际上22万和24万的版本，中控屏仍然是8英寸的小屏，如果是单独设计的8英寸小屏那还好点，可是丰田为了节省成本，直接在原有的大屏面板上嵌入了一块小屏幕，左右两边的黑框可以停下一排游艇，奇丑无比。不仅如此，22万和24万的版本还是塑料方向盘，没有倒车雷达，没有360全景影像，没有无钥匙进入。更夸张的是，主副驾座椅还是手动调节。20多万的电动车，丰田真的是心大，难道不看看周围的竞品吗？哪儿来的自信？要说这车唯一良心的，应该就是L2级的智能驾驶辅助全系标配吧。不过，在20万级的电动车里，它要连这个都不标配，估计要被网友喷出翔来。不仅同级别的电动车几乎都是标配，就连丰田自家10几万的卡罗拉和雷凌都是标配。所以毫无疑问，看bz4X的客户肯定第一时间pass掉了22万和24万的两个版本，那么就只剩下26万、28万和30万三个版本可选了。26万是两驱（前驱）顶配，28和30万都是四驱版本。26万和28万配置几乎一样，其实就是两驱和四驱的差别。可是丰田bZ4X有个很有意思的地方，它的两驱版本配备的是150kw单电机，峰值扭矩266牛米，零百加速7.5秒，CLTC续航615km；而四驱版本前后各有一个80kw的电机，综合最大功率160kw，峰值扭矩337牛米，零百加速6.9秒，CLTC续航560km。也就是说四驱版本的性能并没有增加多少，反倒是续航缩水了50多公里。我觉得没有谁会真的拿一台电动SUV去玩越野吧?虽然丰田与斯巴鲁共享x-mode技术，前后扭矩也会有动态分配，但毕竟是前后轴电机驱动，难不成还给加三把锁，然后搞个扭矩放大多少倍吗？这充其量算是个全轮驱动，说是四驱都算是给足面子了。所以，如果把四驱版本去掉，丰田bZ4X唯一值得入手的，就是两驱顶配26万这个版本。但是我看了一眼配置单，所谓顶配，轮毂还是和低配一样是18寸的（顶配20寸），没有并线辅助，没有电动后备箱，没有车内空气净化，音响全系都是6个扬声器，当然更不可能是什么品牌音响。可能有人会说，丰田bz4x的配置虽然不高，可是续航还行。你刚刚不是说了，两驱CLTC续航可以到615km吗？这里解释一下，CLTC续航是在去年7月1日被用来取代NEDC续航的一种标准，但是CLTC续航被很多专业人士质疑虚标太严重，甚至比NEDC还要严重。比如特斯拉Model 3 Performance，新款从76.8kWh增加到78.4kWh，只多了1.6度电，竟然续航从605km增加到了675km。特斯拉1.6度电能开70km吗？要知道，电动车15kWh/百公里已经算是非常优秀的能耗表现了。说白了，续航增加的原因就是之前用的NEDC，现在换成了CLTC。给大家一组数据对比：NEDC续航484km，CLTC续航就是509km，WLTP续航只有398km。换句话说，A厂家如果用CLTC续航，B厂家用WLTP续航，那肯定是B厂家吃亏。所以现在市面上大部分电动车对外宣传，都会用CLTC续航标准，比如凯迪拉克Lyriq的续航650km；福特Mustang Mach-E续航619km；BMW IX续航665km，这些都是CLTC续航。其实水分都很大，真实续航起码打8折。而且，丰田bZ4X最低配22万的版本，不仅配置丐中丐，甚至电池包都缩水了16度电，CLTC续航才400km，花22万买一台实际续航连国产10来万的电动车都比不过的合资车，我实在想不出来这样的客户图的是啥？有人可能要问，丰田bz4x难道一点亮点都没有吗？那个“高效太阳能充电穹顶”，难道不是丰田独有的技术吗？宣传说“每年吸收能量可行驶1800km呢。就算我每年就开1万公里，如果放在太阳底下充电就能续航1800km，那我岂不是1/5的日子都不用充电了吗？说实话，丰田bZ4X这个所谓车顶太阳能电池板，我看着都想笑，咱们比亚迪F3DM早在2010年就给安排上了，12年前咱们国产车玩剩下的，现在又被拿出来炒作。而且还是只能在最顶配30万的版本上选装。选装之后，分段式天窗就没了，车顶覆盖一片光伏板。光伏发电的效率有多低，这个可能需要专业人士来解释一下。根据我查到的相关资料，一平米的光伏板，如果日照充足的情况下 ，按200w的充电标准，一天日照按4个小时计算，也就是充了1度电左右。如果日照不充足，充电效率也就是50-100w之间，我看着我的65w手机充电器，笑而不语。之前如果关注过丰田bZ4X的朋友，应该知道海外版本还有类似F1赛车的异型方向盘，而且带线控转向。可惜到了国内，这两项都取消了。取消异型方向盘我能理解，毕竟法律法规各个国家和地区不一样，但是线控转向你可以不取消。这玩意虽然贵的要命，但的确是个好东西。英菲尼迪Q50L当年上市的时候，就大吹特吹了通线控转向，算是给老百姓普及了一下这个技术。可惜的是，路面上99%的Q50L都没有这个技术，因为只有售价39.98万的最顶配版本才有线控转向。丰田bZ4X不但顶配没有，选装都不给选。线控转向，简单理解就类似于赛车模拟器，它没有传统机械结构来得那么真实，电机无法模拟轮胎受力带来的方向回跳和小震动。但是线控转向最大的优势就是转向比可以自由变化，转向不再受到机械的限制，它可以让你手感重一些，也可以让你手感轻一些，可以让你在路口轻松调头，也可以让你左右晃动方向盘没有虚位。理论上讲，工程师想怎么调整都可以随心所欲。战斗机上用的就是线控转向，因为它不需要考虑成本问题，也不用考虑驾驶乐趣，电子信号的传递速度肯定优于液压结构。今后无人驾驶如果普及，线控转向大概率也会随之普及。但是目前来看，但凡敢用线控转向技术的，首先要配备3个独立的ECU行车电脑，如果一个出故障，另外两个要保证正常运转。不仅如此，还要配备一套传统的机械转向，如果三个ECU都出故障，系统会立即接合离合器，恢复机械转向连接。听起来是不是很无聊的一个设计？为了一个普普通通的转向功能，消费者要多花这么多冤枉钱。所以，丰田bZ4X更不可能在30万的电动车给你配备这种功能。不过，今后与bZ4X同平台的雷克萨斯RZ，说不定有可能配备线控转向，毕竟丰田都卖这个价了，雷克萨斯RZ不卖个40-50万怎么对得起观众呢？别说3个ECU，给你整6个也不是事。当然，按雷克萨斯对中国消费者双标的态度，能配足3个就不错了，而且就算给1个还是有人跪舔。我看到其他媒体稿件里提到，丰田bZ4X的轴距2850mm，空间堪比汉兰达。数据上看，的确没有错，汉兰达的轴距也是2850mm。可是汉兰达车长4965mm，这车才4690mm，也就比丰田Rav4荣放长了90mm，宽度和高度也和荣放差不多。说白了，就是一台紧凑级suv，为什么大家硬要说这是中型suv呢？电动车由于自身结构的特殊性，没有发动机和变速箱，所以前后轮都会顶边设计，这样一来，轴距自然就变长了。目前为止，同级别电动车的轴距都不会太差。就算有些竞品轴距看起来比丰田bZ4X小一些，你实际去体验看看，空间也不会有明显的感知小很多。还有一些网友猜测，这台车会不会是比亚迪贴了丰田标在卖？咱们有一说一，人家丰田自家的eTNGA架构，不至于还得去抄袭比亚迪吧。比亚迪现在纯电车型都在更新e3.0平台，两者之间还是有很大差别的。再加上丰田bZ4X的电池包用的是丰田和宁德时代共同开发的三元锂电池，这也与比亚迪的磷酸铁锂刀片电池不一样。丰田bZ4X的底盘架构也没预留发动机变速箱和油箱位置，也谈不上是油改电的产品。但是大家注意这个TNGA平台下的产品，今后会衍生出很多差半级的车型，而这些车型宽度不变，只是长度、高度、轴距会有变化。比如卡罗拉和亚洲狮，RAV4荣放和凌放（轴距都没变）。毫无疑问，eTNGA下的丰田电动车肯定也会玩这种手法，疯狂的制造差异化产品，搞得你眼花缭乱 ，光在丰田电动车体系里对比就花了N久时间，当然就没时间和精力去对比其他车型了。在充电方面，bZ4X也没什么亮点。最大150kw充电功率，在400v快充桩上跑满的话，0-80%大约30分钟时间，市面上大部分车都可以做得到。而丰田bz4x的充电口全部在车头两侧，左边是快充口，右边是慢充口。我特别不喜欢充电口在车头的电动车，这是厂家节省成本，但是麻烦了客户的行为。你想想，自家车位上好不容易装了个充电桩，结果每次还得拖根长长的充电线线，一直拉到车头位置。而那些在公用充电桩充电的车主更惨，公用充电桩的充电线很短，你只能车头扎进车位，且不说倒车出车位的时候，左右如果停有车辆，几乎全部都是盲区，非常危险。我们楼下就有一排充电桩，充电桩前面是双车道，很窄，我每次看网约车过来充电，为了让车头进入车位，前前后后倒车无数遍，后面堵着长长的一排车，我看着都心疼。至于丰田bZ4X上面的这块12.3英寸中控屏，以及它的车机系统，我相信大多数人看着就提不起兴趣。说来说去，也就是车家互联、QQ音乐、百度地图、语音控制这些功能，连OTA远程升级都没有，这套车机大家不用抱有太大幻想。车机系统方面，玩过国产新造实力的，保准你觉得这就是上个时代的产物。智能驾驶方面也是一样，虽然标配了L2级智能驾驶辅助，但是丰田bZ4X从头至尾没有宣传自己有多少个毫米波雷达，多少个摄像头，激光雷达更是想都不用想的。说了这么多丰田bZ4X缺这少那的地方，其实总结下来一句话，就是这车性价比太差，我相信稍微有些常识的客户应该是一眼就看出来了。但是丰田为什么有底气给这么一台低配电动车定这么高的价格呢？我觉得有两点原因，一是他的竞品大众ID.4不是也定的差不多价格吗？大众ID.4好歹上汽和一汽还换了个后缀，改改造型卖，丰田bZ4X干脆名字和造型都懒得改，直接放一丰和广丰卖。而ID.4的尺寸还比丰田bZ4X小一圈，各方面参数和配置都差不多，凭什么ID.4能卖这么贵，丰田就不行呢？ID.4一样也有很多人买。况且丰田bZ4X这只是预售价，比如我分析的两驱顶配26万的版本，如果最终上市25.5万，那么跟ID.4的两驱顶配24万多，也就差1万来块钱。丰田应该还是比较自信，这1万多差价，如果大众和丰田二选一，还是有不少人站队丰田的吧。另一点原因，就是丰田毕竟是全球销量第一的汽车公司，在咱中国有1400多家门店，很多老百姓就认这牌子。丰田吃准一部分人还是会把传统观念带到电动车里来，比如保值、耐用、经济、省心等等。所以，你看丰田bz4x的销售政策，第一条就是：10年20万公里免费基础保养。有人一看，这可比雷克萨斯混动的免费保养周期还要长。实际上，电动车保养一次就1-2百块钱，便宜的很。所有销售政策里，也就这一条最吸引人，其他的什么礼包，置换补贴，增购补贴，送电卡都没啥吸引力。可是我有个疑问，按理说不接受电动车的人，应该连丰田电动车也不接受。难道丰田电动车就没有续航焦虑了？就没有保值率问题了？就不会起火自燃了？而那些接受电动车的客户，早把市面上的车型比较了个遍了。他们还能接受丰田bZ4X这么没性价比的产品吗？所以，我觉得丰田bZ4X有点像BBA造电动车的思路， 只是给那些本品牌老客户，用本品牌燃油车置换电动车准备的。不过，丰田如果用老客户存量换市场占有量，这个体量也不小。另外大家注意一个问题，丰田是一家全球车企，在咱们中国市场，是因为可选择的车型太多太多，所以显得丰田bZ4X性价比不高。然而在国外很多市场，电动车选择面并不广，因此丰田bZ4X很可能全球销量并不会差到哪里去，人家毕竟可以调动全球资源，总有些地方的人会认可丰田的电动车。我认识不少造老头乐的厂家，在欧洲有不少代理商呢，老外在郊区开着老头乐代步，可开心了。如果一定要买合资电动车，丰田bZ4X和大众ID.4，我还是偏向ID.4多一些。但是不着急的话，我建议等等日产Ariya，这款车外观和内饰原创度很高，颜值应该不在前两款车之下。更重要的是，日产是从一开始就坚持研发纯电动的车企，曾经的Leaf聆风是全球最畅销的电动车，而且日产在电池安全性方面一直做的很好。只可惜在咱们国内，发力太晚。之前把技术给到了日产启辰晨风，品牌知名度太低，卖的很不好，但是各位可以问问启辰晨风车主，是不是个个用着都很爽。所以想买丰田bZ4X和大众ID.4的客户，强烈建议等日产Ariya上市再做决定。还有朋友问，本田的e:NP1 极湃1和e:NS1怎么样？提到本田的电动车，我是彻底无语，之前都是油改电的划水产品。现在说这款是纯电平台下的产品，但是看起来怎么还那么像新款缤智的造型？难道说最大的卖点就是那块15.2英寸竖立的中控大屏？没有发动机的本田，是没有灵魂的。因此我是不买本田电动车，不知道大家意向如何。可以添加微信46415254加入我们的社群音频图文更新在订阅号： 百车全说每期抽三条留言，每人赠168元的“芥末绿”燃油添加剂一瓶点击订阅，每周三，周六更新会有提醒新听友可以搜索：百车全说2014，百车全说2015，百车全说2016，往期300多个小时的节目可供收听

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本文章发布于订阅号：百车全说，订阅号阅读更加方便，欢迎关注前37分钟聊丰田bZ4X，后半部分聊五一假期小故事。今天这期节目聊聊前不久刚刚预售的丰田bZ4X。由于刚开始预售，网络上软文太多，很多网友看得晕头转向，甚至有些都已经蠢蠢欲动准备下单了。但是看了看钱包，发现30万买台丰田的电动车，总感觉哪里不对。所以后台收到很多人私信，问我这车到底好不好，能不能买？我先说结论，如果你不差钱，信丰田，想玩个新鲜，可以买。但是你要谈性价比，谈科技感，谈娱乐和舒适性配置，市面上大把的车可以把它虐成渣渣。今天这期节目，我们就详细聊聊这款丰田bZ4X，与大家分享一些我的观点。现如今，买电动车的车主也是越来越挑剔了，因为中国应该是目前世界上可以选择的电动车品牌最多的国家。20-30w这个区间，我们也可以找到几十款电动车可以买。特斯拉的Model3、蔚来的ET5、小鹏P5/P7/G3、比亚迪汉/唐还有后续的一系列海洋系列，其他的像是吉利、奇瑞、长城、广汽埃安等等品牌，一堆的电动车躺着被你选，你为什么一定要买丰田bZ4X呢？是这台车长得太帅，让你无法自拔吗？这台车的整体造型设计，与丰田家族传统燃油SUV相比，并没有特别突出的亮点。反倒是前轮上方的两个黑色轮眉格外醒目。按道理说，你要突出越野车的狂放不羁气质，做个撞色处理我也能够理解。可是那两坨不规则的黑色轮眉设计，就像是涂口红涂歪了的感觉，或者说像是侧面的保险杠还没有喷漆就出厂的感觉。我看了一下玫瑰棕，魅力银都是这样两坨黑色在前轮上方，我是无法接受，不知道大家什么感觉。如果你非要送我一辆bZ4X，我会毫不犹豫地选择墨渊黑，用车身的黑色去遮盖这两坨黑色的轮眉。这台车的内饰设计，也没什么出彩的地方。对外展示的都是7英寸全液晶仪表+12.3英寸中控屏的版本。实际上22万和24万的版本，中控屏仍然是8英寸的小屏，如果是单独设计的8英寸小屏那还好点，可是丰田为了节省成本，直接在原有的大屏面板上嵌入了一块小屏幕，左右两边的黑框可以停下一排游艇，奇丑无比。不仅如此，22万和24万的版本还是塑料方向盘，没有倒车雷达，没有360全景影像，没有无钥匙进入。更夸张的是，主副驾座椅还是手动调节。20多万的电动车，丰田真的是心大，难道不看看周围的竞品吗？哪儿来的自信？要说这车唯一良心的，应该就是L2级的智能驾驶辅助全系标配吧。不过，在20万级的电动车里，它要连这个都不标配，估计要被网友喷出翔来。不仅同级别的电动车几乎都是标配，就连丰田自家10几万的卡罗拉和雷凌都是标配。所以毫无疑问，看bz4X的客户肯定第一时间pass掉了22万和24万的两个版本，那么就只剩下26万、28万和30万三个版本可选了。26万是两驱（前驱）顶配，28和30万都是四驱版本。26万和28万配置几乎一样，其实就是两驱和四驱的差别。可是丰田bZ4X有个很有意思的地方，它的两驱版本配备的是150kw单电机，峰值扭矩266牛米，零百加速7.5秒，CLTC续航615km；而四驱版本前后各有一个80kw的电机，综合最大功率160kw，峰值扭矩337牛米，零百加速6.9秒，CLTC续航560km。也就是说四驱版本的性能并没有增加多少，反倒是续航缩水了50多公里。我觉得没有谁会真的拿一台电动SUV去玩越野吧?虽然丰田与斯巴鲁共享x-mode技术，前后扭矩也会有动态分配，但毕竟是前后轴电机驱动，难不成还给加三把锁，然后搞个扭矩放大多少倍吗？这充其量算是个全轮驱动，说是四驱都算是给足面子了。所以，如果把四驱版本去掉，丰田bZ4X唯一值得入手的，就是两驱顶配26万这个版本。但是我看了一眼配置单，所谓顶配，轮毂还是和低配一样是18寸的（顶配20寸），没有并线辅助，没有电动后备箱，没有车内空气净化，音响全系都是6个扬声器，当然更不可能是什么品牌音响。可能有人会说，丰田bz4x的配置虽然不高，可是续航还行。你刚刚不是说了，两驱CLTC续航可以到615km吗？这里解释一下，CLTC续航是在去年7月1日被用来取代NEDC续航的一种标准，但是CLTC续航被很多专业人士质疑虚标太严重，甚至比NEDC还要严重。比如特斯拉Model 3 Performance，新款从76.8kWh增加到78.4kWh，只多了1.6度电，竟然续航从605km增加到了675km。特斯拉1.6度电能开70km吗？要知道，电动车15kWh/百公里已经算是非常优秀的能耗表现了。说白了，续航增加的原因就是之前用的NEDC，现在换成了CLTC。给大家一组数据对比：NEDC续航484km，CLTC续航就是509km，WLTP续航只有398km。换句话说，A厂家如果用CLTC续航，B厂家用WLTP续航，那肯定是B厂家吃亏。所以现在市面上大部分电动车对外宣传，都会用CLTC续航标准，比如凯迪拉克Lyriq的续航650km；福特Mustang Mach-E续航619km；BMW IX续航665km，这些都是CLTC续航。其实水分都很大，真实续航起码打8折。而且，丰田bZ4X最低配22万的版本，不仅配置丐中丐，甚至电池包都缩水了16度电，CLTC续航才400km，花22万买一台实际续航连国产10来万的电动车都比不过的合资车，我实在想不出来这样的客户图的是啥？有人可能要问，丰田bz4x难道一点亮点都没有吗？那个“高效太阳能充电穹顶”，难道不是丰田独有的技术吗？宣传说“每年吸收能量可行驶1800km呢。就算我每年就开1万公里，如果放在太阳底下充电就能续航1800km，那我岂不是1/5的日子都不用充电了吗？说实话，丰田bZ4X这个所谓车顶太阳能电池板，我看着都想笑，咱们比亚迪F3DM早在2010年就给安排上了，12年前咱们国产车玩剩下的，现在又被拿出来炒作。而且还是只能在最顶配30万的版本上选装。选装之后，分段式天窗就没了，车顶覆盖一片光伏板。光伏发电的效率有多低，这个可能需要专业人士来解释一下。根据我查到的相关资料，一平米的光伏板，如果日照充足的情况下 ，按200w的充电标准，一天日照按4个小时计算，也就是充了1度电左右。如果日照不充足，充电效率也就是50-100w之间，我看着我的65w手机充电器，笑而不语。之前如果关注过丰田bZ4X的朋友，应该知道海外版本还有类似F1赛车的异型方向盘，而且带线控转向。可惜到了国内，这两项都取消了。取消异型方向盘我能理解，毕竟法律法规各个国家和地区不一样，但是线控转向你可以不取消。这玩意虽然贵的要命，但的确是个好东西。英菲尼迪Q50L当年上市的时候，就大吹特吹了通线控转向，算是给老百姓普及了一下这个技术。可惜的是，路面上99%的Q50L都没有这个技术，因为只有售价39.98万的最顶配版本才有线控转向。丰田bZ4X不但顶配没有，选装都不给选。线控转向，简单理解就类似于赛车模拟器，它没有传统机械结构来得那么真实，电机无法模拟轮胎受力带来的方向回跳和小震动。但是线控转向最大的优势就是转向比可以自由变化，转向不再受到机械的限制，它可以让你手感重一些，也可以让你手感轻一些，可以让你在路口轻松调头，也可以让你左右晃动方向盘没有虚位。理论上讲，工程师想怎么调整都可以随心所欲。战斗机上用的就是线控转向，因为它不需要考虑成本问题，也不用考虑驾驶乐趣，电子信号的传递速度肯定优于液压结构。今后无人驾驶如果普及，线控转向大概率也会随之普及。但是目前来看，但凡敢用线控转向技术的，首先要配备3个独立的ECU行车电脑，如果一个出故障，另外两个要保证正常运转。不仅如此，还要配备一套传统的机械转向，如果三个ECU都出故障，系统会立即接合离合器，恢复机械转向连接。听起来是不是很无聊的一个设计？为了一个普普通通的转向功能，消费者要多花这么多冤枉钱。所以，丰田bZ4X更不可能在30万的电动车给你配备这种功能。不过，今后与bZ4X同平台的雷克萨斯RZ，说不定有可能配备线控转向，毕竟丰田都卖这个价了，雷克萨斯RZ不卖个40-50万怎么对得起观众呢？别说3个ECU，给你整6个也不是事。当然，按雷克萨斯对中国消费者双标的态度，能配足3个就不错了，而且就算给1个还是有人跪舔。我看到其他媒体稿件里提到，丰田bZ4X的轴距2850mm，空间堪比汉兰达。数据上看，的确没有错，汉兰达的轴距也是2850mm。可是汉兰达车长4965mm，这车才4690mm，也就比丰田Rav4荣放长了90mm，宽度和高度也和荣放差不多。说白了，就是一台紧凑级suv，为什么大家硬要说这是中型suv呢？电动车由于自身结构的特殊性，没有发动机和变速箱，所以前后轮都会顶边设计，这样一来，轴距自然就变长了。目前为止，同级别电动车的轴距都不会太差。就算有些竞品轴距看起来比丰田bZ4X小一些，你实际去体验看看，空间也不会有明显的感知小很多。还有一些网友猜测，这台车会不会是比亚迪贴了丰田标在卖？咱们有一说一，人家丰田自家的eTNGA架构，不至于还得去抄袭比亚迪吧。比亚迪现在纯电车型都在更新e3.0平台，两者之间还是有很大差别的。再加上丰田bZ4X的电池包用的是丰田和宁德时代共同开发的三元锂电池，这也与比亚迪的磷酸铁锂刀片电池不一样。丰田bZ4X的底盘架构也没预留发动机变速箱和油箱位置，也谈不上是油改电的产品。但是大家注意这个TNGA平台下的产品，今后会衍生出很多差半级的车型，而这些车型宽度不变，只是长度、高度、轴距会有变化。比如卡罗拉和亚洲狮，RAV4荣放和凌放（轴距都没变）。毫无疑问，eTNGA下的丰田电动车肯定也会玩这种手法，疯狂的制造差异化产品，搞得你眼花缭乱 ，光在丰田电动车体系里对比就花了N久时间，当然就没时间和精力去对比其他车型了。在充电方面，bZ4X也没什么亮点。最大150kw充电功率，在400v快充桩上跑满的话，0-80%大约30分钟时间，市面上大部分车都可以做得到。而丰田bz4x的充电口全部在车头两侧，左边是快充口，右边是慢充口。我特别不喜欢充电口在车头的电动车，这是厂家节省成本，但是麻烦了客户的行为。你想想，自家车位上好不容易装了个充电桩，结果每次还得拖根长长的充电线线，一直拉到车头位置。而那些在公用充电桩充电的车主更惨，公用充电桩的充电线很短，你只能车头扎进车位，且不说倒车出车位的时候，左右如果停有车辆，几乎全部都是盲区，非常危险。我们楼下就有一排充电桩，充电桩前面是双车道，很窄，我每次看网约车过来充电，为了让车头进入车位，前前后后倒车无数遍，后面堵着长长的一排车，我看着都心疼。至于丰田bZ4X上面的这块12.3英寸中控屏，以及它的车机系统，我相信大多数人看着就提不起兴趣。说来说去，也就是车家互联、QQ音乐、百度地图、语音控制这些功能，连OTA远程升级都没有，这套车机大家不用抱有太大幻想。车机系统方面，玩过国产新造实力的，保准你觉得这就是上个时代的产物。智能驾驶方面也是一样，虽然标配了L2级智能驾驶辅助，但是丰田bZ4X从头至尾没有宣传自己有多少个毫米波雷达，多少个摄像头，激光雷达更是想都不用想的。说了这么多丰田bZ4X缺这少那的地方，其实总结下来一句话，就是这车性价比太差，我相信稍微有些常识的客户应该是一眼就看出来了。但是丰田为什么有底气给这么一台低配电动车定这么高的价格呢？我觉得有两点原因，一是他的竞品大众ID.4不是也定的差不多价格吗？大众ID.4好歹上汽和一汽还换了个后缀，改改造型卖，丰田bZ4X干脆名字和造型都懒得改，直接放一丰和广丰卖。而ID.4的尺寸还比丰田bZ4X小一圈，各方面参数和配置都差不多，凭什么ID.4能卖这么贵，丰田就不行呢？ID.4一样也有很多人买。况且丰田bZ4X这只是预售价，比如我分析的两驱顶配26万的版本，如果最终上市25.5万，那么跟ID.4的两驱顶配24万多，也就差1万来块钱。丰田应该还是比较自信，这1万多差价，如果大众和丰田二选一，还是有不少人站队丰田的吧。另一点原因，就是丰田毕竟是全球销量第一的汽车公司，在咱中国有1400多家门店，很多老百姓就认这牌子。丰田吃准一部分人还是会把传统观念带到电动车里来，比如保值、耐用、经济、省心等等。所以，你看丰田bz4x的销售政策，第一条就是：10年20万公里免费基础保养。有人一看，这可比雷克萨斯混动的免费保养周期还要长。实际上，电动车保养一次就1-2百块钱，便宜的很。所有销售政策里，也就这一条最吸引人，其他的什么礼包，置换补贴，增购补贴，送电卡都没啥吸引力。可是我有个疑问，按理说不接受电动车的人，应该连丰田电动车也不接受。难道丰田电动车就没有续航焦虑了？就没有保值率问题了？就不会起火自燃了？而那些接受电动车的客户，早把市面上的车型比较了个遍了。他们还能接受丰田bZ4X这么没性价比的产品吗？所以，我觉得丰田bZ4X有点像BBA造电动车的思路， 只是给那些本品牌老客户，用本品牌燃油车置换电动车准备的。不过，丰田如果用老客户存量换市场占有量，这个体量也不小。另外大家注意一个问题，丰田是一家全球车企，在咱们中国市场，是因为可选择的车型太多太多，所以显得丰田bZ4X性价比不高。然而在国外很多市场，电动车选择面并不广，因此丰田bZ4X很可能全球销量并不会差到哪里去，人家毕竟可以调动全球资源，总有些地方的人会认可丰田的电动车。我认识不少造老头乐的厂家，在欧洲有不少代理商呢，老外在郊区开着老头乐代步，可开心了。如果一定要买合资电动车，丰田bZ4X和大众ID.4，我还是偏向ID.4多一些。但是不着急的话，我建议等等日产Ariya，这款车外观和内饰原创度很高，颜值应该不在前两款车之下。更重要的是，日产是从一开始就坚持研发纯电动的车企，曾经的Leaf聆风是全球最畅销的电动车，而且日产在电池安全性方面一直做的很好。只可惜在咱们国内，发力太晚。之前把技术给到了日产启辰晨风，品牌知名度太低，卖的很不好，但是各位可以问问启辰晨风车主，是不是个个用着都很爽。所以想买丰田bZ4X和大众ID.4的客户，强烈建议等日产Ariya上市再做决定。还有朋友问，本田的e:NP1 极湃1和e:NS1怎么样？提到本田的电动车，我是彻底无语，之前都是油改电的划水产品。现在说这款是纯电平台下的产品，但是看起来怎么还那么像新款缤智的造型？难道说最大的卖点就是那块15.2英寸竖立的中控大屏？没有发动机的本田，是没有灵魂的。因此我是不买本田电动车，不知道大家意向如何。可以添加微信46415254加入我们的社群音频图文更新在订阅号： 百车全说每期抽三条留言，每人赠168元的“芥末绿”燃油添加剂一瓶点击订阅，每周三，周六更新会有提醒新听友可以搜索：百车全说2014，百车全说2015，百车全说2016，往期300多个小时的节目可供收听

New York-based tech company NS1, a leader in smart network control solutions, is establishing a presence in Cork, Ireland as a major step to further the company's global presence. The company is set to hire at least 30 computer engineers from various backgrounds and levels of expertise over the next two years. NS1 is scaling up its cloud-based NS1 Connect platform which orchestrates all the critical control points to understand, automate, and secure every digital interaction. With billions of users, applications and devices connected through the NS1 platform, only NS1 delivers immediate intelligence and control across evolving infrastructure. This project has been supported by the Irish Government through IDA Ireland. Tánaiste and Minister for Enterprise, Trade & Employment Leo Varadkar said: “This announcement from NS1 will see the creation of 30 new roles over the next two years to help expand its Connect platform. It's great news that the company has chosen Cork for this expansion, once again highlighting the rich pool of talent available in the area. This new facility will play a key role in the expansion of NS1's global engineering presence and I wish the team all the best in this exciting new chapter.” NS1 Can Access and Grow Local Talent A key component of NS1's expansion is building an engineering center of excellence, where NS1 can access and grow local talent interested in challenging work and in making a meaningful impact to the evolution of the company's products. Ireland stood out as an exceptional source of skilled, diverse and passionate talent, well-versed in cloud development and innovation. The local NS1 management team in Cork is comprised of experienced, dedicated tech leaders who are passionate about their work, and are driven in establishing and leading high impact, high growth teams. What makes NS1 stand out in the market is the variety of roles and opportunities to grow skills and experiences. Beyond offering senior tech opportunities, the company will train emerging tech talent in the latest cloud technologies and advanced programming languages such as Go. “When locations for expansion were initially explored by NS1, Cork was top of the list for me based on the incredible success I've had establishing centers of excellence here in the past. The type of talent I've seen in the Cork market aligns perfectly with our expansion strategy as we build products at a scale to meet global demand,” said David Coffey, Chief Product Officer at NS1. NS1 strongly supports a hybrid working model, with remote work options available, but is also securing office space in Cork City that will provide an innovative, highly collaborative work environment. As NS1 expands its EMEA presence, complementing its sales-focused London team, Ireland will serve as a hub for future hires throughout Europe. Growing the Ireland site is targeted to grow NS1's global engineering presence, working in close collaboration with other sites in the United States and Vietnam. IDA Ireland's Head of Regional Business Development, Ray O'Connor said: “The decision by NS1 to establish in Cork City is terrific news and a welcome addition to the South West region's strong Technology cluster. Winning jobs and investment in regional locations continues to be a priority for IDA Ireland. I wish NS1 every success with this expansion.” For more information about NS1 hiring, visit: More about Irish Tech News Irish Tech News are Ireland's No. 1 Online Tech Publication and often Ireland's No.1 Tech Podcast too. You can find hundreds of fantastic previous episodes and subscribe using whatever platform you like via our Anchor.fm page here: If you'd like to be featured in an upcoming Podcast email us at Simon@IrishTechNews.ie now to discuss. Irish Tech News have a range of services available to help promote your business. Why not drop us a line at Info@IrishTechNews.ie now to find out more about how we can help you reach our audience. You can also find and follow...

Cloud adoption is often driven by modernization efforts, but the increased investment usually represents a broader approach to digital transformation because, in reality, the public cloud is not always the best option. And once organizations undergo modernization efforts, they often find the increasing complexity creates new challenges. As more companies have gained confidence in the benefits of cloud computing (scalability, operational velocity, elasticity), they have learned new tricks of the trade, including: avoiding vendor lock-in; ensuring resource management and capacity planning; and blending legacy applications and infrastructure. Register for this episode of DMRadio to learn how today's innovators are tackling the challenges of heterogeneous infrastructure and solving for the complexity of hybrid cloud. Host @eric_kavanagh will interview Kris Beevers of NS1 and AB Periasamy of MinIO.

這兩天父親發生意外，在和母親對話、處理的過程中，引發我內在一連串的發生與家庭動力的轉化。這兩天也是情緒花園第十屆療癒師培訓，我卻花大部分的注意力在梳理原生家庭的過往、和母親對話，以及觀看自己的內在，雖然無法好好參與課程，卻覺得這也是完美的共時共振。 我們都在整體的流中，經驗著自身的多重表達。整體給予支持和補充，然而整合的意願始終源於自己。 回想下方行動調頻提到的兩個時間點：1987年我發生嚴重車禍（蹲下去撿掉在地上的玩具，被父親不慎倒車壓到車底）、2013年則是長達10年的感情關係結束，兩次都是跟陽性能量的衝撞與斷裂。這一次爸爸的意外，我看見自己的成長、看見自己的力量、看見我對爸爸媽媽的愛、看見我的敞開見底、看見我的意願、看見我的勇氣...........我很感謝自己在七年前，選擇踏上自我療癒的旅程，也很感謝自己沒有放棄。 祝福每一個人的接收與擴展，被整合進來的，都是生命的禮物。 今日提問 我是否活出我所相信的？白巫師，使我活出我所相信的。 今天我如何讓自己感受到更多連結？ 銀河三角靜心 左肩—左手小指—頂輪 行動調頻 Kin34是1987和諧匯聚那年的年度力量，而今年在新天狼星週期也正好是NS1.34 (第三十四年)，而今天的完美拓展銀河星系黃種子，則是2013.7.26開始的年度力量。回憶一下這兩個時間點的自己，尤其是從2013年到現在，你跨越了什麼？成就了什麼？放下了什麼？領悟了什麼？當時的你，做出了哪些選擇使你成為現在的你？

"Better Yourself. Believe In Yourself"  An accomplished businessman and lifelong athlete, Diaa Nour cofounded Ventum LLC in 2015 after successfully exiting the telecom sector. Ventum began as a passion project seeking to change the bike industry by introducing new aerodynamic technology and the first triathlon-specific bike. As CEO of Ventum, Diaa has grown the business from a humble startup in Miami to its current headquarters here in Utah. He's led the development of the innovative NS1 road bike and recent introduction of the GS1 gravel bike.   Diaa has traveled the world developing and being involved in sport, and truly lives and tests the product that his company builds and provides athletes around the world.  We have met Diaa as our team has become loving customers of Ventum bikes and have had the opportunity to try and true their product.  Over the last year as inventory has been difficult to get for today's roadies and gravel racers, the Ventum Team has equipped the team with all our needs - every time!  

NS1.34.1.2.225 Segundo dia da lua magnética do morcego, ano da semente elétrica. --- Send in a voice message: https://anchor.fm/claudia-cereser/message

Links: Cybersecurity industry reacts as antivirus pioneer John McAfee found dead: https://www.csoonline.com/article/3623188/cybersecurity-industry-reacts-as-antivirus-pioneer-john-mcafee-found-dead.html Storms & Silver Linings: Avoiding the Dangers of Cloud Migration: https://beta.darkreading.com/cloud/storms-silver-linings-avoiding-the-dangers-of-cloud-migration 7 ways technical debt increases security risk: https://www.csoonline.com/article/3621754/7-ways-technical-debt-increases-security-risk.html New DNS Name Server Hijack Attack Exposes Businesses, Government Agencies: https://www.darkreading.com/vulnerabilities—threats/new-dns-name-server-hijack-attack-exposes-businesses-government-agencies/d/d-id/1341377 CISO Jason Lee on Zoom's response to its pandemic security challenges: https://www.csoonline.com/article/3622671/ciso-jason-lee-on-zooms-response-to-its-pandemic-security-challenges.html Software-Container Supply Chain Sees Spike in Attacks: https://beta.darkreading.com/cloud/software-container-supply-chain-sees-spike-in-attacks Four states propose laws to ban ransomware payments: https://www.csoonline.com/article/3622888/four-states-propose-laws-to-ban-ransomware-payments.html Senators propose bill to help tackle cybersecurity workforce shortage: https://thehill.com/policy/cybersecurity/560318-senators-propose-bill-to-help-tackle-cybersecurity-workforce-shortage Expecting the Unexpected: Tips for Effectively Mitigating Ransomware Attacks in 2021: https://beta.darkreading.com/vulnerabilities-threats/expecting-the-unexpected-tips-for-effectively-mitigating-ransomware-attacks-in-2021 What Lies Ahead for K-12 Cybersecurity?: https://securityboulevard.com/2021/06/what-lies-ahead-for-k-12-cybersecurity/ How to Protect Healthcare Data from Ransomware Attacks: https://www.ccsinet.com/blog/data-from-ransomware-attacks/ System Resilience: What Exactly Is It?: https://insights.sei.cmu.edu/blog/system-resilience-what-exactly-is-it/ Resilience Engineering: An Introduction: https://www.bmc.com/blogs/resilience-engineering/ Charting a path to software resiliency: https://medium.com/walmartglobaltech/charting-a-path-to-software-resiliency-38148d956f4a 7 Best Practices to Build and Maintain Resilient Applications and Infrastructure: https://thenewstack.io/7-best-practices-to-build-and-maintain-resilient-applications-and-infrastructure/ TranscriptJesse: Welcome to Meanwhile in Security where I, your host Jesse Trucks, guides you to better security in the cloud.Announcer: If your mean time to WTF for a security alert is more than a minute, it's time to look at Lacework. Lacework will help you get your security act together for everything from compliance service configurations to container app relationships, all without the need for PhDs in AWS to write the rules. If you're building a secure business on AWS with compliance requirements, you don't really have time to choose between antivirus or firewall companies to help you secure your stack. That's why Lacework is built from the ground up for the cloud: low effort, high visibility, and detection. To learn more, visit lacework.com. That's lacework.com.Jesse: I've heard the term ‘fail gracefully' hundreds of times. What the heck does that really mean? Most people don't think too hard on how their system should gracefully bow out rather than the old school method of complete failures and horrible restarts. Resilient software engineering is the discipline of making software and systems fail in ways that minimize and isolate failures while continuing to deliver service and availability. Basically, it means if you have a failure from hardware or dependencies, like a database, your service continues to work correctly and the broken parts just get shut down and replaced.Cloud-native software using microservices or even dynamically deployed containers or systems is the perfect way to implement resiliency in your operations. Look toward the next development cycle of your software and systems to begin implementing this immediately if you don't already have this in place. None of this really makes sense until you see an example, so think of it this way: you have a web-based service for customers to see their account profile and order history. It's built to scale with containers using AWS Elastic Kubernetes service—or EKS—and it is designed so when a system throws errors of any kind, that container is closed down. Then the Aws Elastic Load Balancer—or ELP—service points all subsequent requests to a different container instance in EKS.In that scenario, if a container is breached in a security event, or if something simply fails due to a software bug or data corruption, the service recovers by tossing a new system while yanking out the old system. This is security by designing self-healing IT systems. You get both security and stability for the same effort. This is DevSecOps in practice and shows how a shift-left mindset for your organization is the best possible approach for your business or mission.Jesse: Meanwhile, in the news. Cybersecurity industry reacts as antivirus pioneer John McAfee found dead. Sure John McAfee was clearly in his own blend of strange and eccentric, but he launched an entire industry vertical 34 years ago. The computer age has been around long enough now that the founders of the early megacorps are all fading away. Don't forget our history, and if you ever asked yourself, “What would John McAfee do?” Please go do the opposite unless you plan on launching a successful business.Storms & Silver Linings: Avoiding the Dangers of Cloud Migration. This reminds me of the weeping and gnashing that happened every time some new wiki went up at various jobs and projects. I learned to hate wikis because they were always horribly organized and always out of date. Heed the advice here: if it's out of date, archive it somewhere else and don't migrate to your shiny new cloud.7 ways technical debt increases security risk. Fixing old software in a fast-moving world is like the scope creep of how much stuff we acquire between moving houses or offices. You can either take advantage of touching everything to purge and organize, or you can blindly shove it all in a box and move it. We all think we'll get around to fix it later. Nope. We don't. We increase our risk in ways we can't see. Go fix your stuff.New DNS Name Server Hijack Attack Exposes Businesses, Government Agencies. There is so much information someone can gather about your organization by collecting information that was supposed to go to you. AWS closed this hole, but not all DNS services have. DNS is a resilient service, but it was never designed with modern attacks in mind. I love DNS and I hate DNS. You should too.CISO Jason Lee on Zoom's response to its pandemic security challenges. Explosive growth is scary; 30X growth in months is terrifying. Zoom did it. Can you? Very few companies can stay functioning, let alone secure in those situations.Software-Container Supply Chain Sees Spike in Attacks. I don't think I've beat the drum of supply-chain attacks enough. These are on the rise now that there is a great example of how effective these are. I sure hope you've secured your supply chain. I'm sure you haven't, but we can always hope.Four states propose laws to ban ransomware payments. This is a bit like making it illegal to pay kidnappers or terrorists. I know many companies will get owned and pay anyway, and regulations to stop money flowing to criminals is nothing new. There will be loopholes found and exploited, like in all things. Keep up with what laws affect your organization and how you perform security. To stop ransomware pandemic, start with the basics. We security people repeat ourselves constantly because implementing the basic security defenses mitigates most risk for most organizations. Please go do at least the [CIST 00:05:51] top five if you can't do all of them.Senators propose bill to help tackle cybersecurity workforce shortage. The US federal government is pushing hard on cybersecurity now that they were owned in front of the whole world by the SolarWinds and MS Exchange debacles. Like most companies, cybersecurity seems to be an afterthought in budgets and priorities, until the media gets to pummel them for weeks on end in the news.Announcer: If you have several PostgreSQL databases running behind NAT, check out Teleport, an open-source identity-aware access proxy. Teleport provides secure access to anything running behind NAT, such as SSH servers or Kubernetes clusters and—new in this release—PostgreSQL instances, including AWS RDS. Teleport gives users superpowers like authenticating via SSO with multi-factor, listing and seeing all database instances, getting instant access to them using popular CLI tools or web UIs. Teleport ensures best security practices like role-based access, preventing data exfiltration, providing visibility, and ensuring compliance. Download Teleport at goteleport.com. That's goteleport.com.Jesse: Expecting the Unexpected: Tips for Effectively Mitigating Ransomware Attacks in 2021. Much of the advice I see for mitigating any horrific attack is a huge amount of labor, but all the work is necessary. Ransomware can wipe out whole backups, destroy codebases that aren't recoverable, it can steal, or even worse, publicly disclose your secrets. Don't think you are ready for a large ransomware attack. These things are driven by people who have studied your systems and might have been in them for weeks.What Lies Ahead for K-12 Cybersecurity? As the president and principal of a small elementary school and a technologist, I've implemented mostly cloud services to support the school operations and classroom work. Many of us in tech who work with large organizations in state, local, and higher ed—called SLED—national, or federal governments, and large corporations forget that there are small and mid-sized businesses—or SMBs—and K through 12 schools that also have the same concerns we do. After all, we all run Windows, Mac OS, Unix, and Linux, middleware and cloud services.How to Protect Healthcare Data from Ransomware Attacks. If all of us protected our data like we ought to for protected or personal health information—or PHI—and personally identifiable information—or PII—then we'd have far less breaches and even less exfiltration and disclosure of our private information.And now for the tip of the week. Introducing software resiliency is far from trivial, so let's look at how to get started understanding this. First, to understand what this all means, read some primers like System Resilience: What Exactly Is It? from the Carnegie Mellon University Software Engineering Institute and Resilience Engineering: An Introduction from BMC's DevOps blog. Then look at how to implement this. Charting a path to software resiliency is a Medium piece written for the Walmart Global Tech blog and 7 Best Practices to Build and Maintain Resilient Applications and Infrastructure, a piece on the new stack by Kris Beevers of NS1. There are hundreds of quality resources out there on these subjects, but this should get you started on your new path to a brighter, cloudier future. And that's it for the week, folks. Securely yours Jesse Trucks.Jesse: Thanks for listening. Please subscribe and rate us on Apple and Google Podcast, Spotify, or wherever you listen to podcasts.Announcer: This has been a HumblePod production. Stay humble.

Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Eva Harris and Janet Smith Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Eva Harris on TWiV 228 Zika virus in Nicaragua (virology blog) How an antibody block NS1-mediated endothelial dysfunction (Science) Broadly protective antibody against NS1 (Science) Letters read on TWiV 725 Timestamps by Jolene. Thanks! Weekly Picks Alan – Science Photographer of the Year Awards Rich – Bar Keeper’s Friend Kathy – Perseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission. Vincent – COVID-19 dataset Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Eva Harris and Janet Smith Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Eva Harris on TWiV 228 Zika virus in Nicaragua (virology blog) How an antibody block NS1-mediated endothelial dysfunction (Science) Broadly protective antibody against NS1 (Science) Letters read on TWiV 725 Timestamps by Jolene. Thanks! Weekly Picks Alan – Science Photographer of the Year Awards Rich – Bar Keeper’s Friend Kathy – Perseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission. Vincent – COVID-19 dataset Listener Picks Matthew - Remembering the colleagues we lost to COVID-19 Lori - Iceberger Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In today's GROW B2B FASTER episode, our guest is John Kaplan, co-founder and Managing Partner of Force Management, and the host is  Sammy Gebele, Managing Partner and founder of SAWOO.That's in it for you1. How Force Management started and John's daily motivation to keep going2. How John helped successful companies grow faster3. How to tackle marketing & sales expenses during a crisis4. What is going wrong in the B2B marketing environment nowadays?5. The 4 magic questions that will help you align your B2B sales & marketing  6. Most important things for sales leaders when scaling a company7. What should everybody in B2B sales and marketing start doing?About JohnBefore co-founding Force Management, John served as Senior Vice President of International Sales Operations for PTC, a software and professional services company listed at the NASDAQ. PTC went 43 straight quarters of never missing their number to wall street!His company Force Management provides real-world experience to help clients define sales solutions and create management tools that produce measurable results. They e.g. helped NS1 increase its bookings by 60% or JAMA software increase its new and expansion business growth by 50%.ShownotesYou can find John on LinkedIn: linkedin.com/in/johnkaplanfm or contact him via email at kaplan@forcemanagement.comJohn's company Force Management helps clients define sales solutions and create management tools: https://www.forcemanagement.com/John recommended a guided meditation by the organization "Art of Living"  https://www.artofliving.org/meditation/online-guided-meditationJohn mentioned the book "The Power of Habit" as one of his favourite business books https://www.amazon.com/Power-Habit-What-Life-Business/dp/081298160XJohn also recommends the book "Extreme Ownership" as one of his favourites  https://www.amazon.com/Extreme-Ownership-U-S-Navy-SEALs-ebook/dp/B00VE4Y0Z2This episode is sponsored by SAWOO - " We help you grow your B2B business faster"

Kris Beevers is co-founder and CEO of NS1, a leader in modern application and access networking. He leads a team of industry experts as they create products to automate the deployment and delivery of the world's most trafficked internet and enterprise applications. Kris is a recognized authority on DNS and global application delivery, and speaks and writes about building and deploying high performance, at scale, globally distributed internet infrastructure. He holds a Ph.D. in Computer Science from RPI, and prior to founding and leading NS1, he built CDN, cloud, bare metal, and other infrastructure products at Voxel, which sold to Internap (NASDAQ: INAP) in 2011.

13亮曆銀河意識播報星系座標 NS1.33.3.22 卓爾金曆 KIN196 磁性黃戰士 對等KINKIN65宇宙紅蛇 PSI KIN55 電力藍鷹 ⚛G-F⚛ KIN186 自我存在白世界橋 月亮藍風暴年 電力鹿之月 黃色收成之周 第1日頂輪 目標 DALI 拿起內在信任的權杖， 勇者無懼不需要草木皆兵， 而是認出自己就是太陽孩子的存在， 拾起步伐穿越恐懼回到平靜的心， 認出心中真心的渴望與饗望的生活， 帶著神聖恩典的祝福大步向前， 實踐夢想目標的藍圖。 回歸自然法則，發現生活共時⭐️ ⭕️宜，信任內在的指引勇往直前 ⛔️不宜，莽撞、焦慮、急躁 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

13亮曆銀河意識播報星系座標 NS1.33.3.11 KIN 185 電力紅蛇 對等KINKIN141 光譜紅龍 PSI KIN 41 月亮紅龍 ⚛G-F⚛ KIN 179 行星藍風暴 月亮藍風暴年 電力鹿之月 白色淨化之周 第4日臍輪 曆法播報 讓夢想點燃生命的熱情， 啟動內在亢達里尼的力量， 在生活中校準響望的目標， 允許自己身體與心合一前行， 架構美好的生命旅程。 回歸自然法則，發現生活共時⭐️ ⭕️宜，啟動生活的熱情、啟動亢達里尼的力量、照顧身體 ⛔️不宜，缺乏耐心、為難身體 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

13亮曆銀河意識播報星系座標 NS1.33.3.9 對等KINKIN3 電力藍夜 PSI KIN 38 水晶白鏡 ⚛G-F⚛ KIN173 自我存在的紅天行者 月亮藍風暴年 電力鹿之月 白色淨化之周 第2日海底輪 SELI 流動 曆法播報 雙倍夢想的力量引領智慧的戰士， 為夢想而綻放生命的色彩， 穿越未知的恐懼， 在橋的另一頭是光的引路進入無限的風采。 回歸自然法則，發現生活共時⭐️ ⭕️宜，作夢、睡覺 ⛔️不宜，欺負自己感受匱乏 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

卓爾金曆是KIN178 太陽白鏡子2020/09/23 13亮曆銀河意識播報星系座標 NS1.33.3.4 對等KINKIN232 光譜黃人 PSI KIN 58韻律白鏡 ⚛G-F⚛ KIN184 月亮黃種子 月亮藍風暴年 電力鹿之月 紅色啟動之周 第4日臍輪 KALI 建立 曆法播報 平靜的心照見關係中的自己， 允許光亮包圍相遇的每一個發生， 用內在的豐盛對自己提問而看見生命的熱情， 成為生活中真實自己的智慧勇士。 回歸自然法則，發現生活共時⭐️ ⭕️宜，照鏡子、打扮美麗、享受豐盛 ⛔️不宜，急躁固執 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

Sam Bennett proves he is worthy of the sprinters jersey. The boys discuss the finale and where this race ranks in the history of the Tour. They wonder how Pogacar will handle the new found fame and applaud the absolute class displayed by Roglic. We close out the show giving out their BOOM Stick of the Tour award. THEMOVE is presented by OURA. Visit OURA to learn more about the most accurate sleep and health device on the market. Today's episode is brought to you by PowerDot. Our listener's get 20% of their purchase using the code THEMOVE at checkout.  Visit LMNT to order your next electrolyte drink mix.  Visit ROKA and use the code THEMOVE at checkout for 20% off your first purchase. Visit Ventum Racing to enter to win a custom fit NS1 bike.  

"This was the greatest Tour de France I have ever seen," says George Hincapie, who has also completed 17 Tours.  The guys break down an epic display by Pogacar to capture yellow. They also discuss how they feel for Roglic and Jumbo-Visma. They close the show with predictions on the Champs. THEMOVE is presented by OURA. Visit OURA to learn more about the most accurate sleep and health device on the market. Today's episode is brought to you by PowerDot. Our listener's get 20% of their purchase using the code THEMOVE at checkout.  Visit LMNT to order your next electrolyte drink mix.  Head over to Hammerhead to  pre order your Karoo 2 today. Visit Ventum Racing to enter to win a custom fit NS1 bike.  

The guys open up the show discussing the controversial decision to expel the director form Jumbo-Visma over a bike inspection. George and Lance debate whether or not they would change bikes during the TT on Saturday. They also comment about the great Tour that Team Sunweb is having after taking another stage today. THEMOVE is presented by OURA. Visit OURA to learn more about the most accurate sleep and health device on the market. Today's episode is brought to you by PowerDot. Our listener's get 20% of their purchase using the code THEMOVE at checkout.  Visit LMNT to order your next electrolyte drink mix.  Visit ROKA and use the code THEMOVE at checkout for 20% off your first purchase. Visit Ventum Racing to enter to win a custom fit NS1 bike.

Kris Beevers is the Co-founder and CEO of NS1, the leader in modern application and access networking. Kris is a recognized authority on global application delivery and DNS. He joins the show from his new, aptly named boat, Social Distance. Early on, when he was in the process of choosing his co-founders, Kris sought out people who he had a strong and respectful personal relationship with. As the business has grown, the roles of the leadership team have morphed, changed, and become better defined. Now as CEO, Kris considers his job to be hiring great people and letting them run. One thing he wishes he knew during his series A fundraise was that most investors are more interested in investing in the team rather than the product. They want to know you have a great team that will hustle for success. Glenn and Kris also discuss the important impact hiring a COO had on the business and Kris recommends hyper-communication and swift decision making as tools for success during these times.

Ineos Grenadiers goes 1-2. A perfect day on the bike for Kwiatkowski and Carapaz. The guys discuss the gravel section, Porte's flat with no support and a bad day for Uran. They close the show talking about the last opportunity tomorrow for teams that have not won a stage. THEMOVE is presented by OURA. Visit OURA to learn more about the most accurate sleep and health device on the market. Today's episode is brought to you by PowerDot. Our listener's get 20% of their purchase using the code THEMOVE at checkout. Visit ROKA and use the code THEMOVE at checkout for 20% off your first purchase. Head over to Hammerhead to register to win a free Karoo2.  Visit Ventum Racing to enter to win a custom fit NS1 bike.

卓爾金曆是KIN170 磁性白狗2020/09/15 13亮曆銀河意識播報星系座標 NS1.33.2.24 對等KIN KIN152太陽黃人 PSI KIN222磁性白風 ⚛G-F⚛ KIN160 自我存在的黃太陽 月亮藍風暴年月亮蠍子之月 黃色收成之周 第3日眉心輪 GAMMA 平靜 架構屬於自己穩定愛的形式， 打造屬於自身獨特的美麗藝術， 用輕鬆與順流的心， 允許自己情緒流動， 看見生活中所有愛的形式發生。 回歸自然法則，發現生活共時⭐️ ⭕️宜，看見自己的愛、寫下愛自己的方式 ⛔️不宜，掌控他人批判自己 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o https://fb.me/e/5jEkPrjbb Powered by Firstory Hosting

卓爾金曆是KIN171 月亮藍猴2020/09/16 13亮曆銀河意識播報星系座標 NS1.33.2.25 對等KINKIN28 月亮黃星星 PSI KIN222磁性白風 ⚛G-F⚛ KIN33共振紅天行者 月亮藍風暴年月亮蠍子之月 黃色收成之周 第4日臍輪 KALI 建立 曆法播報 拓展屬於自身內在舒心的和諧與優雅， 穿越未知的恐懼，遊戲探索於生活之中， 用愛推動自己創造夢想旅程， 在心靈的祝福聲中， 為自己吹響起屬於生命藍圖的號角。 回歸自然法則，發現生活共時⭐️ ⭕️宜，玩起來、打扮自己覺得的美麗、讚美自己 ⛔️不宜，太嚴肅 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

The Germans get on the board for the first time since 2018. Trentin looks to join the battle for the green jersey. Lance wonders what is going on with Ineos and their tactics. The group comments on how strong Jumbo continues to go and they give their predictions for a tough State 17.  THEMOVE is presented by OURA. Visit OURA to learn more about the most accurate sleep and health device on the market. Today's episode is brought to you by PowerDot. Our listener's get 20% of their purchase using the code THEMOVE at checkout.  Visit ROKA and use the code THEMOVE at checkout for 20% off your first purchase. Use the code HYPETHEMOVE for 10% off at Hyperice Visit Ventum Racing to enter to win a custom fit NS1 bike.

Spiderman conquers the never ending climb up Col de la Loze. Lopez shines for Columbia as his fellow countrymen, Bernal, does not start. Bahrain sets a wicked pace but their plan for Landa falls apart. The guys discuss the Queen Stage, Sepp Kuss' day and another hard day tomorrow.  THEMOVE is presented by OURA. Visit OURA to learn more about the most accurate sleep and health device on the market. Today's episode is brought to you by PowerDot. Our listener's get 20% of their purchase using the code THEMOVE at checkout. Visit ROKA and use the code THEMOVE at checkout for 20% off your first purchase. Head over to Hammerhead to register to win a free Karoo2.  Visit Ventum Racing to enter to win a custom fit NS1 bike.

卓爾金曆是KIN166 行星白世界橋2020/09/11 13亮曆銀河意識播報 星系座標 NS1.33.2.20 月亮藍風暴年月亮蠍子之月 藍色蛻變之周 第6日LIMI 胃輪 淨化 曆法播報 讓豐盛引領拾起無限的勇氣， 在永恆之中的當下種下一顆顆心願的種子， 實踐所有的嚮望， 忠於自己的心就是每個完美的發生 回歸自然法則，發現生活共時⭐️ ⭕️宜，溝通、斷捨離 ⛔️不宜，執著 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

卓爾金曆是KIN164 銀河星系黃種子2020/09/09 13亮曆銀河意識播報 星系座標 NS1.33.2.18 月亮藍風暴年月亮蠍子之月 藍色蛻變之周 第4日KALI 臍輪 建立 曆法播報 綻放生命熱情、舞蹈身體的感知， 用心靈的祝福歌唱生活的旋律， 在清晰視野的確信朝向目標， 用著屬於自己的節奏創造美麗的藍圖 回歸自然法則，發現生活共時⭐️ ⭕️宜，訂定目標、放慢腳步 ⛔️不宜，焦躁 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

卓爾金曆是KIN157磁性紅地球2020/09/02 13亮曆銀河意識播報 星系座標 NS1.33.2.11 月亮藍風暴年月亮蠍子之月 白色淨化之周 第4日KALI 臍輪 建立 曆法播報 允許自然的頻率引領心靈的發聲， 每一個當下敞開心的看見巧合， 用屬於自己的步伐實現一顆顆意念的種子， 翱翔在廣大的生命藍圖中， 因為心與自己同行而譜出高高低低， 豐富多彩的生活曲調。 回歸自然法則，發現生活共時⭐️ ⭕️宜，自然而然、順流 ⛔️不宜，控制 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

卓爾金曆是KIN150 共振白狗2020/08/26 13亮曆銀河意識播報 星系座標 NS1.33.2.4 月亮藍風暴年月亮蠍子之月 紅色啟動之周 第4日KALI 臍輪 建立 讓心靈的聲音引領愛的祝福， 在流動與淨化之中， 用遊戲的頻率建構起自身的和諧， 在每一刻允許自己， 溫暖的陪伴所有改變的發生。 回歸自然法則，發現生活共時⭐️ ⭕️宜，溫柔的善待自己與他人 ⛔️不宜，為難自己、固執不變通 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

卓爾金曆是KIN144 磁性黃種子2020/08/20 13亮曆銀河意識播報 星系座標 NS1.33.1.26 月亮藍風暴年磁性蝙蝠之月 黃色收成之周 第5日ALPHA 喉輪 釋放 用平靜的心校準目標與方向， 連結內在與外在的自己， 讓陰性的柔軟與陽性堅定的力量整合一體， 誠實的面對自己與他人， 在每個當下提起勇氣穿越無限， 用屬於自身的美好照亮前方的道路， 永恆的愛將支持著每個人成就這趟美好的旅程。 回歸自然法則，發現生活共時⭐️ ⭕️宜，校準目標、種下美好的意念種子 ⛔️不宜，急躁 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

卓爾金曆是KIN143 宇宙藍夜2020/08/19 13亮曆銀河意識播報 星系座標 NS1.33.1.25 月亮藍風暴年磁性蝙蝠之月 黃色收成之周 第4日KALI 臍輪 建立 帶著喜悅的心實踐生命夢想的藍圖， 記起我們都是獨一無二光的存在， 拾起自身的勇氣， 在夜空中穿越恐懼探索未知， 因為連結所有的自己而完整， 透過屬於自己的和諧秩序， 用純真與輕鬆的頻率， 為這趟地球之旅記錄下永恆完美體驗的蛻變記憶。 回歸自然法則，發現生活共時⭐️ ⭕️宜，點亮夢想、寫下夢想、信任直覺 ⛔️不宜，匱乏不滿足 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

卓爾金曆是KIN139 太陽藍風暴2020/08/15 13亮曆銀河意識播報 星系座標 NS1.33.1.21 月亮藍風暴年磁性蝙蝠之月 藍色蛻變之周 第7日Silio 心輪 發射 讓愛引領流動的發生， 在強而有力自然風雨的催化下， 淨化與清理自己， 為生命再次種下屬於自己生命藍圖中， 定將開花的美麗種子。 回歸自然法則，發現生活共時⭐️ ⭕宜，改變、勇敢 ⛔不宜，為難自己 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

卓爾金曆是KIN138 銀河白鏡2020/08/14 13亮曆銀河意識播報 星系座標 NS1.33.1.20 月亮藍風暴年磁性蝙蝠之月 藍色蛻變之周 第6日LIMI 胃輪 淨化 傾聽心靈的祝福， 相信屬於自己夢想的創造， 用遊戲與輕鬆的心滋養身心， 在無限廣闊的空間中， 穿越恐懼的未知建構自己的和諧頻率。 回歸自然法則，發現生活共時⭐️ ⭕宜，擁抱自己、反省 ⛔不宜，固執己見、埋怨他人 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.10.245225v1?rss=1 Authors: de Rozieres, C. M., Joseph, S. Abstract: Influenza A virus (IAV) is a highly contagious human pathogen responsible for nearly half a million deaths each year. Non-structural protein 1 (NS1) is a crucial protein expressed by IAV to evade the host immune system. Additionally, NS1 has been proposed to stimulate translation because of its ability to bind poly(A) binding protein 1 (PABP1) and eukaryotic initiation factor 4G (eIF4G). We analyzed the interaction of NS1 with PABP1 using quantitative techniques. Our studies show that NS1 binds as a homodimer to PABP1, and this interaction is conserved across different IAV strains. Unexpectedly, NS1 does not bind to PABP1 that is bound to poly(A) RNA. Instead, NS1 only binds to PABP1 free of RNA, suggesting that translation stimulation does not occur by NS1 interacting with the PABP1 molecule attached to the mRNA 3'-poly(A) tail. We propose that NS1 binds to the eIF4G complex at the 5'-end of the mRNA and recruits the RNA-free PABP1, which may stimulate translation initiation by promoting the association of the ribosomal subunits. Copy rights belong to original authors. Visit the link for more info

卓爾金曆是KIN120 電力黃太陽2020/07/27 13月亮曆銀河意識播報 星系座標 NS1.33.1.2 月亮藍風暴年磁性蝙蝠之月 紅色起動之周 第2日 大家早安 我是星際旅人 太陽黃太陽Rudy 今天是新天狼星第一個52年的第33年， 月亮藍風暴年的第1個月亮， 磁性蝙蝠之月，紅色啟動之周的第2日， 電力黃太陽的日子，銀河常數KIN為120。 今天來自銀河中心的提醒是我該如何給與服務。 答案是，黃太陽。黃太陽使我給予服務。 太陽是光的使者，溫暖的普照著萬物與眾生， 從來沒有區別的無條件給予服務， 並提供所有的能源滋養著一切， 每個光亮的照躍下都好像在對我們說， 其實所有的相對、比較與不同， 只是為了讓我們可以去看見一個不一樣的視野與不一樣的可能， 藉由每次的覺察與看見， 讓發散出去的心收攝回來， 回到內在的平靜中， 去感覺著當下的自己正在擁有什麼不同的體驗與感受， 然後， 用感謝與擁抱來調整與接納不同的自己與經驗， 讓完整能夠回到心中， 因完整而使內在的神性光芒， 可以無窮無盡的輻射展開， 透過一次次的調整與接納中， 我們可以看見更完整自己， 也因為懂得如何愛自己，自然也能同理他人， 使心中的愛無限展開， 不如就藉由今天的黃太陽， 讓自己成為那個想要成為的人， 去做些想要做的事吧， 在這個神聖的藍圖中， 我們將因全然為自己選擇與負責的每個片刻， 撒下每個美麗的種子， 迎接著那片如我們所是的美麗花園。 說到這裡不知道大家對於電力黃太陽有什麼樣的感覺呢? 祝福大家 在電力黃太陽的日子， 讓清晰的視野點亮內在的明鏡， 使無窮無盡的豐盛與喜悅照亮屬於自己美好生活。 回歸自然法則，發現生活共時⭐️ ⭕宜，溫暖、曬太陽 ⛔不宜，不負責 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

卓爾金曆是KIN117 宇宙紅地球2020/07/24 13亮曆銀河意識播報 星系座標 NS1.32.13.28 磁性白巫師年宇宙龜之月 黃色收成之周 第7日 大家早安 我是星際旅人 太陽黃太陽Rudy 今天是新天狼星第一個52年中的第32年， 磁性白巫師年的第13個月亮， 宇宙烏龜之月，黃色收成之周的第7日， 宇宙紅地球的日子，銀河常數KIN為117。 今天來自銀河中心的提醒是， 我如何回到當下活出自己超越到下一個階段? 紅地球使我回到當下活出自己超越到下一個階段。 今天我們來到了紅蛇波符的最後一天， 也是磁性白巫師年的收尾的日子， 最後一個階段磁性的紅蛇走到宇宙的紅地球， 也同時讓磁性的白巫師到宇宙的白世界橋， 替整年度做個總結與準備回圈上升到下一個能量場域中， 大家準備好了嗎?! 宇宙的紅地球在提醒著我們， 在我們的內在、 你我的DNA之中儲存了許多珍貴的重要訊息， 每個訊息都是累生累世積蓄下來的美好體驗與力量， 所有體驗都是為了支持著你我完成每一次新的旅程， 然而，身體對於我們在地球而言， 就是最好的導航器， 是每一個人最好的陪伴者， 陪伴著我們一生的學習與成長， 給予我們全然的支持與方向， 使自己可以在每次當下的時刻能夠更加清晰對準， 所在的位置、想要去的方向，以及目的究竟在什麼地方， 那麼， 我們都是否願意相信著自己內在心靈導航的力量呢? 當身體發出心靈的警示訊號， 或是用直覺與生疾病提醒著我們， 是時候重整休息，是時候暫時停下來了， 讓自己重新回到平靜，再一次校準方向， 是否也願意敞開心的與身體合作， 靜下來聆聽著他的聲音呢， 或是依然與集體意識的能量共振， 每一次我們都擁有選擇， 而選擇都只是為了讓你我能夠看見自己正在做些什麼， 讓意識能夠回到屬於自己的覺知， 讓自己為自身的選擇負起全然的責任， 因此， 我們需要的是相信著自己， 不論當下是哪一種選擇， 其實都是靈魂與自已做好的完美生命藍圖的約定， 是在最高神聖的指導原則中進行者， 沒有其他人包含自己能夠給予批評與評斷， 也從來都不會與他人相同， 因為，一直以來， 每一個人都是獨一無二的完美力量與藝術， 只是， 你是否願意擁抱自己的選擇， 並全然的陪伴著自己每一刻的體驗呢? 說到這裡， 不知道大家對於與宇宙紅地球的日子有什麼樣的感受? 祝福大家 在宇宙紅地球的日子， 用心靈的聲音，回到屬於自身的內在導航， 用清晰的視野陪伴自己在地球的每一個體驗。 回歸自然法則，發現生活共時⭐️ ⭕宜，信任與擁抱自己 ⛔不宜，責怪自己、不負責 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

kin109 超頻紅月2020/07/16 13亮曆銀河意識播報 今日星系座標 NS1.32.13.20 磁性白巫師年宇宙龜之月 藍色蛻變之周 第6日 當日調頻主題 我如何使自己擁有最大力量？ 答案是，紅月。紅月使我擁有最大力量。 心靈引領情緒的感受， 允許生命的流動淨化與清理， 用愛與祝福包容自己照耀陰暗， 拾起為自身負責的勇氣， 讓未知引領探索穿越恐懼綻放多彩斑斕的光芒。 回歸自然法則，發現生活共時⭐️ ⭕宜，多喝水、泡澡、與水有關的療癒 ⛔不宜，暴怒不負責 ✨IN LAK'ECH！ALA K'IN✨ ✨讓生命中的一切回歸自己， 相信自己將在輕鬆幸福與喜悅中迎向未來的榮耀✨ ♥️靖娟Rudy KIN100太陽黃太陽 FB@SOLARSUN.Rudy LINE@byo1053o Powered by Firstory Hosting

Read more https://thenewstack.io/ In this episode of The New Stack Makers, we talk to Kris Beevers about the importance of the traffic manager role and so much more as we look ahead to this year in enterprise tech. Seven years ago, Beevers co-founded NS1, the networking automation company or, as he calls it, “the system of record for many, many of the key domains and the applications on the Internet today.” He says that each of us interacts with NS1 dozens of times a day, like when we are connecting on LinkedIn or sharing files on DropBox. NS1 sits at the base of this new traffic management stack, steering that traffic across our increasingly complex and distributed systems. This stack also includes content networking delivery networks (CDN), load-balancing tooling, edge networking footprints, Service Mesh, service discovery, and egress optimization. This new role isn't just about measuring if traffic is working correctly, but really understanding both your users and systems to know how traffic is reaching the application, if you're using the right networking providers and venders, and if you're choosing data centers, clouds and CDNs effectively. This new traffic management role sits at the heart of greater site reliability engineering trends like chaos engineering and progressive delivery. It's about using your tooling stack to understand how your whole tooling reacts to prepare for the worst.

Everything breaks at 3:00 a.m. No one wants a team of engineers managing incidents on little to no sleep. Think about how tired you were the morning after the last all-nighter you pulled. Coffee can only do so much. If you work in any type of technical operations role you know how easy it is for on-call to take over your life. When managing an on-call team, you must think about the human side of on-call to avoid employee burnout and alert fatigue. In this session we will outline a four-step process to streamline incident management, review how to manage alerts through VictorOps, and give your team their lives back! Speaker(s) Bethany Abbott, TechOps Manager, NS1 Slides PDF link - https://conf.splunk.com/files/2019/slides/IT1968.pdf?podcast=1577146210 Product: VictorOps Track: IT Operations Level: Good for all skill levels

Everything breaks at 3:00 a.m. No one wants a team of engineers managing incidents on little to no sleep. Think about how tired you were the morning after the last all-nighter you pulled. Coffee can only do so much. If you work in any type of technical operations role you know how easy it is for on-call to take over your life. When managing an on-call team, you must think about the human side of on-call to avoid employee burnout and alert fatigue. In this session we will outline a four-step process to streamline incident management, review how to manage alerts through VictorOps, and give your team their lives back! Speaker(s) Bethany Abbott, TechOps Manager, NS1 Slides PDF link - https://conf.splunk.com/files/2019/slides/IT1968.pdf?podcast=1577146223 Product: VictorOps Track: IT Operations Level: Good for all skill levels

Everything breaks at 3:00 a.m. No one wants a team of engineers managing incidents on little to no sleep. Think about how tired you were the morning after the last all-nighter you pulled. Coffee can only do so much. If you work in any type of technical operations role you know how easy it is for on-call to take over your life. When managing an on-call team, you must think about the human side of on-call to avoid employee burnout and alert fatigue. In this session we will outline a four-step process to streamline incident management, review how to manage alerts through VictorOps, and give your team their lives back! Speaker(s) Bethany Abbott, TechOps Manager, NS1 Slides PDF link - https://conf.splunk.com/files/2019/slides/IT1968.pdf?podcast=1577146261 Product: VictorOps Track: IT Operations Level: Good for all skill levels

Hey guys and Welcome to the Pacing & Racing Podcast. The Canadian Triathlon Podcast Made In Mind for the Age Group Triathletes. I am really excited to say our latest guest is the Co-Founder of one of my favorite bike companies, Ventum Racing, and that is Diaa Nour! Now if you watched the 2019 IRONMAN World Championships in KONA this year then you’ll probably recall seeing Diaa interviewed during the race when the athletes were just starting out in the early km's of the Ventum Bike Course! In this quick interview, you were able to catch a glimpse of the man behind the scenes who took part in creating the first-ever design of the Ventum Bikes alongside co-founder Jimmy Seear! Now in today’s episode you’ll hear how he and Jimmy came together to take a risk and going with their guts by creating a new bike in what was a VERY niche and competitive market back in 2014! Since 2014 they have created the Ventum One which is their flagship model, their Ventum Z which is the most economical version, and their Ventum Signature which is upwards of $32,000 USD! They also JUST released a UCI Legal Ventum Road Bike called the NS1 which I am SUPER pumped to chat about because as well all know this could be a game-changer for Super League athletes and even the athletes preparing for Tokyo 2020! Diaa also dives into the latest bike initiatives they are taking on and will be coming out with new VERY exciting bike designs next year! Have a listen to find out! It’s an excellent podcast today so sit back, relax, and enjoy the episode!

On today's episode, you’ll hear how Bethany Abbott went from filling prescriptions as a pharmacy tech to transforming the on-call culture at NS1 as the Tech Ops manager...but not before experiencing what it’s like to be the only woman in a massive lecture hall...in all of her classes. Now Bethany is on a mission to bring diversity to our industry by introducing young girls to math and tech early in their education through her organization. Bethany has some incredibly insightful tips for hiring and managing a diverse, resilient tech team that truly loves coming to work - you won’t want to miss this!

President Trump declares a state of emergency over the threat from foreign adversaries and the companies they control. (And yes, Huawei, he’s looking at you.) Dutch intelligence is said to be investigating the possibility of backdoors in telecommunications networks. Concerns about spyware proliferation rise. Cipher stunting is observed in the wild. Titan security keys are spoofable. Meaconing airliners. And misconfigurations expose PII in Russia. Emily Wilson from Terbium Labs on the surprisingly open nature of online sales of elicit goods and services. Guest is Kris Beevers from NS1 on DNS security and management technology. For links to all of today's stories check our our CyberWire daily news brief: https://thecyberwire.com/issues/issues2019/May/CyberWire_2019_05_16.html  Support our show

Kristen worked with Evan Rich, the Director of Customer Success at NS1, as he built out their first health scoring system. This episode covers that process, what it took to build, how that reporting helped his team, and what he would recommend to other leaders looking to do the same.

The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Quantum dots to visualize influenza entry (PNAS) Quantum dots (Wikipedia) Flavivirus NS1 triggers endothelial dysfunction (Cell Rep) Image credit Letters read on TWiV 535 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Hotel Influenza Alan- Your town’s climate in 60 years Dickson- BMC Research in Progress Photo Competition Rich-  NASA's Opportunity Rover Mission on Mars Ends (landing animation) Vincent - Watch a single cell become a complex organism in six minutes Listener Pick Anne- Pathogenesis II Kickstarter Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Quantum dots to visualize influenza entry (PNAS) Quantum dots (Wikipedia) Flavivirus NS1 triggers endothelial dysfunction (Cell Rep) Image credit Letters read on TWiV 535 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Hotel Influenza Alan- Your town’s climate in 60 years Dickson- BMC Research in Progress Photo Competition Rich-  NASA's Opportunity Rover Mission on Mars Ends (landing animation) Vincent - Watch a single cell become a complex organism in six minutes Listener Pick Anne- Pathogenesis II Kickstarter Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Christian Saide and Devin Bernosky of NS1 join Aaron and Mike to talk about what NS1 does and how they leverage the Elastic stack to provide data-driven DNS. The latest news regarding Elastic going public and changes to Kibana are mentioned and we answer the question: 'What is an availability zone in the context of Elastic Cloud?'

On episode #007 of the Digital Pratik Show, we are gonna change the DNS and point our domain & hosting space at the same location which is NS1.BLUEHOST.COM & NS2.BLUEHOST.COMGo ahead and change it for your domain & Bluehost if you have recently purchased them!Also, by the way, you can now Enrol in Free "Digital Marketing Automation Course" now whose market value is $2997 but it will be free for you forever.Join Digital Pratik University today and become a lifetime member for free at: www.digitalpratikuniversity.com Follow me on Instagram: www.instagram.com/digitalpratik for 3 new video posts & 20-30 stories on daily basis.--- Send in a voice message: https://anchor.fm/digitalpratik/message

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk. Links for this episode: Influenza splicing regulates infection (Cell Reports) Reporting on flu splicing from NPR, BBC, NBC Splicing of influenza RNA 8 (jpg) Bacteriophage T7 remodeling during infection (Science) Cryo-ET of intact cells (Trends Cell Biol) T7: The Movie (YouTube) Cry0-EM vs Cryo-ET (Wikipedia) Virus caught in the act (e! Science News) Letters read on TWiV 220 Weekly Science Picks Kathy - Journal of Virology Image GalleryRich - Phage T7 Genetics and Physiology and slab gelsAlan - PeerJ (press release)Vincent -  Virologia en Español Listener Pick of the Week Dave - Thingiverse pathogens and proteins  Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Respiratory syncytial virus (RSV) is recognised as the most frequent cause of severe lung infections in infants and cattle worldwide. Currently, no effective treatments are available and the development of a successful vaccine has been hampered by the fact that natural infection does not provide complete and durable protection. RSV nonstructural proteins, NS1 and NS2, are strong inhibitors of IFN α/β-production by specifically preventing interferon regulatory factor (IRF)-3 phosphorylation. However, the exact mechanisms leading to NS protein-mediated inhibition of IRF3 remain to be unravelled. One of the objectives of this study was to identify amino acid domains in the human respiratory syncytial virus (HRSV) nonstructural proteins (NS) responsible for their ability to ablate the IFN-β signalling pathway. Furthermore, I wanted to find out at which level of this signalling pathway the NS proteins exert their suppressive activity and which are their major cellular targets. HRSV strains A2 and Long differ in their ability to block interferon type I synthesis. Sequence analysis of their NS proteins revealed the presence of an amino acid residue in the NS2 protein with a potential role for RSV IFN-inhibitory functions. Two recombinant bovine respiratory syncytial (BRSV) viruses harbouring HRSV NS1 and NS2 genes were generated and tested in their ability to restrict IFN-β synthesis. These recombinant viruses differed only in the identity of the residue at position 26 of the HRSV NS2 protein: rBRSVh1/2 has a Threonine as in the Long strain, while in rBRS h1/2*T26I this amino acid was mutated into an Isoleucin similarly to A2 virus. Sets of in vitro tests revealed that IFN-β induction was impaired by rBRSVh1/2*T26I when compared to rBRSV h1/2. Analysis of the transcriptional factors (AP-1, NF-kB and IRF3) involved in the activation of IFN-β synthesis provided evidence that the inhibitory ability of rBRSVh1/2*T26I was correlated to a selective block of IRF3. The mutation (T26I) in the NS2 protein did neither effect the NF-kB activation pathway nor perturbed the IFN-resistance characteristics of the chimeric viruses. IRF3 is activated upon phosphorylation mediated by IKK-related kinases (TBK1 and IKK-ε). TBK1 was therefore cloned from a human lung cDNA library and its biological activities regarding the induction of IFN-β were compared in mock-infected and infected cells. rBRSVh1/2*T26I and HRSV A2 precluded virus-induced IRF3 activation by interfering with TBK1 functions. No direct interaction between TBK1 and NS2 protein was demonstrated indicating that the kinase TBK1 may not be the sole target involved in RSV mechanisms of evasion of the innate immune response. Recombinant IFN-inducible rabies viruses expressing HRSV Long-derived (rGFP-Ph2/1) or HRSV A2-like (rGFP-Ph2*T26I/1) NS proteins were also generated. The HRSV NS2 protein expressing an Isoleucin (NS2*T26I) at position 26 was not able to suppress IFN-β induction and to rescue the growth of the recombinant eGFP-Ph2*T26I/1 in interferon-competent cells. A low expression of the mutated NS2*T26I protein was probably the reason of this failure. In summary, these results show that the HRSV NS2 protein possesses an intrinsic IFN-β inhibitory activity, which is achieved throughout a selective inhibition of the IRF3 activation pathway. The block appears to be exerted at the level of IRF3-kinase TBK1. Interferonantagonist functions of the HRSV NS2 protein are linked to a particular amino acid motif in the N-terminus of the protein. Identification of this amino acid domain and of TBK1 as the cellular target provide a better insight of how the HRSV NS2 protein prevents the establishment of the antiviral innate immune response and therefore it might contribute to the development of an effective vaccine.

HRSV ist eine häufige und weltweit verbreitete Ursache von Infektionen des Respirationstraktes. Es führt zu einer entzündlichen Erkrankung der respiratorischen Schleimhäute mit Mukosaödem, Hypersekretion und Bronchospasmus. Die Übertragung des viralen Erregers erfolgt durch Tröpfcheninfektion oder Kontakt mit kontaminierten Gegenständen. HRSV-Infektionen zeigen die höchste Inzidenz bei Säuglingen, vor allem in den ersten zwei bis sechs Lebensmonaten. Bei 25% bis 40% dieser Säuglinge nimmt die Erkrankung einen schweren Verlauf mit Befall des unteren Respirationstraktes in Form einer HRSV-Bronchiolitis oder -Pneumonie. Bei 0,5% bis 2,0% ist eine stationäre Behandlung im Krankenhaus erforderlich. Die Inzidenz nimmt wegen des zunehmend effektiveren Immunsystems mit dem Alter ab. Erwachsene und ältere Kinder zeigen meist keine Symptome bzw. Symptome einer leichten Erkältung. Reinfektionen im Laufe des Lebens sind häufig. Eine effektive kausale Therapie bei HRSV-Infektionen steht derzeit nicht zur Verfügung. Bei Patienten mit leichtem Krankheitsverlauf ist keine spezielle Behandlung erforderlich, therapiert wird symptomatisch. Aktuell ist keine spezifische Prävention in Form einer aktiven Impfung oder als effektive antivirale Therapie etabliert. Angesichts der hohen Inzidenz von HRSV-Infektionen und -Reinfektionen sowie der enormen gesundheitlichen und wirtschaftlichen Auswirkungen ist ein effektiver Impfstoff gegen HRSV als Forschungsziel vorrangig. Das Genom von HRSV, das zur Ordnung der Mononegavirales gehört, besteht aus einem negativ-orientierten RNA-Einzelstrang mit einer Länge von 15 222 Nukleotiden (beim A2-Stamm) und kodiert für zehn subgenomische mRNAs in der Reihenfolge 3’-leader, NS1, NS2, N, P, M, SH, G, F, M2(1+2), L, trailer-5’, die zur Expression von elf viralen Proteinen führen: fünf RNP-assoziierte Proteine, das sind das Nukleoprotein N, das Phosphoprotein P, die große katalytische Untereinheit L der RNA-Polymerase und der Transkriptionselongationsfaktor M2-1 sowie das nicht essentielle M2-2-Protein; vier Hüllproteine, dazu zählen das nicht-glykosylierte Matrixprotein M und drei Oberflächenproteine, im Einzelnen das Fusionsprotein F, das Anheftungsprotein G und das kleine hydrophobe Protein SH; zwei Nicht-Strukturproteine NS1 und NS2. NS1 und NS2 zeichnen die Pneumoviren vor allen anderen Viren der Ordnung der Mononegavirales aus. Beide NS-Proteine sind im Virion nur in Spuren nachweisbar, während sie in infizierten Zellen akkumulieren. Die beiden für die Proteine NS1 und NS2 kodierenden, nichtüberlappenden Gene liegen am 3‘-Ende des Genoms direkt im Anschluss an die leader-Region. NS1 und NS2 stimmen in den vier carboxyterminalen Aminosäuren überein, ansonsten weisen sie keine Sequenzähnlichkeiten auf. Das NS1-Gen hat eine Länge von 552 nt und kodiert für ein leicht saures Protein von 139 AS und 15,7 kD. Das NS2-Gen ist 503 nt lang und kodiert für ein basisches Protein von 124 AS und 14,7 kD. Die für die Ordnung der Mononegavirales charakteristische progressive Attenuation der Transkription sowie die Genlokalisation von NS1 und NS2 am 3‘-Ende lassen auf die höchste Transkriptionsrate für NS1- und NS2-mRNA unter den zehn HSRV-mRNA schließen, was auf eine bedeutende Rolle der NS1- und NS2-Proteine in infizierten Zellen hindeutet. NS1 und NS2 antagonisieren im Zusammenwirken die durch alpha-IFN und beta-IFN induzierte antivirale Antwort des Wirtsorganismus. Hierfür ist eine Koexpression beider NS-Proteine unbedingt erforderlich, ein NS-Protein allein zeigt keine derartige Aktivität. Der Mechanismus, mit dem HRSV die IFN-Antwort des Wirtsorganismus umgeht, ist unklar. In dieser Arbeit wurde die Funktion der NS-Proteine von klinischen HRSV-Isolaten aus fünf bis fünfzehn Monate alten Kindern untersucht. Durch die Anzucht der klinischen HRSV-Isolate in HEp-2-Zellkultur unter identischen Bedingungen wurden zunächst patientenabhängige Faktoren ausgeschaltet und damit die Grundlage für die Vergleichbarkeit der Wachstumseigenschaften der Isolate geschaffen. In den daraufhin erstellten Wachstumskurven konnten deutlich voneinander abweichende Wachstumverhalten der Isolate aufgezeigt werden. Der Befund, dass 3/4 der Bronchiolitis hervorrufenden HRS-Viren hohe infektiöse Titer (>106 infektiöse Viruspartikel/ ml an Tag 3) erreichten, während dies nur bei 1/3 der Bronchitis verursachenden Viren zu beobachten war, könnte auf eine Korrelation zwischen Wachstum in vitro und Pathogenität in vivo hindeuten. Um dies zu belegen, müsste eine größere Zahl von klinischen Isolaten analysiert werden. Die beiden Nicht-Strukturproteine versetzen HRSV in die Lage, die antivirale IFN-Antwort der Wirtszelle zu umgehen. Durch Behandlung von Virus-infizierten Zellkulturen mit IFN ließ sich nachweisen, dass alle klinischen HRSV-Isolate die Eigenschaft der IFN-Resistenz gleichermaßen besitzen und erst durch unphysiologisch hohe IFN Dosen eine wesentliche Inhibierung der Virusreplikation erreicht werden kann. Die in gleicher Weise ausgeprägte α-IFN-Resistenz bei den in Virulenz und Wachstumsgeschwindigkeit unterschiedlichen Viren deutete bereits darauf hin, dass diese Resistenz essentiell für alle klinischen RSV-Isolate ist, und dass zusätzliche Faktoren für das Maß der Aggressivität der Erreger verantwortlich sind. Mittels Nukleotid- und Aminosäuresequenzanalysen von NS1 und NS2 konnte dies weitgehend bestätigt werden. Anhand von RNA aus den HRSV-Isolaten wurde mit Hilfe des Enzyms Reverse Transkriptase cDNA von NS1 und NS2 synthetisiert, die nach dem Prinzip der PCR in vitro amplifiziert wurde. In anschließenden Klonierungsarbeiten wurden aus dem Vektor pBluescript II SK (–) und NS1-DNA bzw. NS1+NS2-DNA als Insert Plasmide konstruiert, in denen die Gensequenzen von NS1 und NS2 ermittelt und rechnergestützt in die entsprechenden Aminosäuresequenzen translatiert wurden. Die Analyse der NS-Sequenzen zeigte eine überraschend hohe Konservierung. Die Isolate waren einschließlich des Long-Stamms diesbezüglich untereinander sehr ähnlich. Diese Beobachtung stimmt mit der IFN-Resistenz überein und zeigt die Bedeutung der NS-Proteine. Die Ergebnisse dieser Arbeit deuten darauf hin, dass Abweichungen in den Sequenzen der übrigen Gene sowie patientenbezogene Faktoren wie Abwehrlage und anatomische Beschaffenheit des Respirationstraktes als Grund für die Unterschiede im Schweregrad der HRSV-Infektion eine Rolle spielen. Angesichts der stabilen Koexpression beider Nicht-Strukturproteine und des dadurch bedingten effektiven IFN-Escape sichern die Gene NS1 und NS2 die Überlebensfähigkeit von HRSV in vivo und stellen ebenso geeignete wie interessante Angriffspunkte in der Entwicklung eines attenuierten Lebendimpfstoffs dar.

Among the Paramyxoviridae, only members of the subfamily Pneumovirinae like Respiratory Syncytial Virus (RSV) encode two nonstructural proteins, NS1 and NS2. These two proteins cooperatively mediate type I interferon resistance and prevent induction of interferon in infected cells. Interactions of NS1 and NS2 proteins in every combination were shown by using the yeast-two-hybrid system. Therfore, NS1 and NS2 are able to form homo- and hetero(oligo)mers in infected cells. Although RSV replicates exclusively in the cytoplasm, NS-Proteins are localized in the cytoplasm as well as in the nucleus. Expression of an enlarged NS1 fusion protein, EGFP-NS1-BRSV N, resulted in the same nuclear and cytosolic localisation indicating that nuclear localisation is not due to diffusion but rather to an active transport. Thus, NS-Proteins should have particular functions in the nucleus of infected cells. Furthermore, yeast-two-hybrid screening of a lung cDNA expression library using NS1 of bovine RSV (BRSV) as a bait, identified cDNA clones encoding several nuclear proteins and one cytosolic protein. BRSV NS2 protein and NS-Proteins from other pneumoviruses (HRSV, PVM) were also able to interact with the identified cellular proteins in yeast. The isolated cDNAs encode the nuclear proteins CDK4BP (p34SEI-1 or TRIP-Br1), RanBP16, MM-1, DEAD Box Helicase p68 and the cytosolic β-COPI. Specific interactions were determined by mutational analysis of BRSV NS1 in yeast. Co-immunoprecipitation from lysates of eukaryotic cells confirmed the interaction of both BRSV NS-Proteins with the cellular proteins. The interaction of MM-1 and p68 with both NS-Proteins was also shown in GST pull down assay in vitro. Engineered BRSV encoding a truncated p68 showed accelerated replication in MDBK and Vero cells, whereas growth of NS1/NS2 deletion mutants expressing the truncated p68 was unaffected. This indicates that the presence of NS-Proteins is a prerequisite for the acceleration of BRSV growth by truncated p68. Furthermore, replication of BRSV was attenuated on HeLa cells in which expression of p68 was knocked down by specific siRNA, whereas replication of the unrelated Rabies virus was not. Thus, p68 is a nuclear target protein for the NS-Proteins and supports BRSV replication in vitro. Growth and division of host cells is necessary for optimal BRSV replication and like p68, most of the identified nuclear protein interactors are related to regulation of the cell cycle and cell division, respectively. Therefore, NS-Proteins appear to influence the cell cycle for optimal replication of BRSV by targeting such proteins. Hence, with the yeast-two-hybrid system, the first cellular interaction partners were identified indicating new functions of NS-Proteins in the viral replication cycle.

Bovine respiratory syncytial virus (BRSV), family Paramyxoviridae, subfamily Pneumovirinae, is a major etiological agent of respiratory tract disease in calves. A peculiarity of pneumoviruses is the presence of two unique nonstructural protein genes, NS1 and NS2. We show that both BRSV NS proteins are necessary and sufficient to mediate IFN resistance. This function can also be transferred to another, unrelated virus, Rabies virus. The mechanism of IFN resistance is conserved among the Pneumovirinae since the NS proteins of human RSV (HRSV) and of Pneumoniavirus of Mice (PVM) are also able to mediate IFN resistance in a similar manner. Furthermore, both BRSV NS proteins are able to block the induction of IFN by inhibiting the activation of interferon regulatory factor 3 (IRF-3). As a result, BRSV is able to block the establishment of a cellular antiviral state. The characterization of interactions between virus (NS proteins) and the host cell (IFN system) will have important implications in the development of HRSV/BRSV vaccines