Podcasts about ping li

These days Taiwan is known to be the most free and democratic country in Asia, but it wasn't always that way. It's hard to imagine that Taiwan has had a very dark period of history during which there was massive censorship. At one time Taiwan had the longest period of martial law in the world at 38 years. During the martial law period from 1949 to 1987, and the White Terror era that extended beyond the lifting of Taiwan's martial law, there was no freedom of speech, expression or thought, and advocating for the independence of Taiwan was a crime punishable by death. This episode examines how Taiwan's transformation from an authoritarian state to a democracy, has impacted Taiwan's media environment.   Related Links: https://talkingtaiwan.com/dr-wei-ping-li-how-taiwans-media-environment-changed-from-martial-law-era-to-present/   I spoke with Wei-Ping Li about the laws and mechanisms of the censorship from Taiwan's martial law era and the impact it had on Taiwan's media environment, and how Taiwan's media environment had changed since then.   Wei-Ping is speaking in a personal capacity (as a media scholar who studied Taiwanese media) and the views expressed in this interview were all her own personal opinions.   About Wei-Ping Li   Wei-Ping Li is a research fellow at Taiwan FactCheck Center. She collaborates with fact-checkers to monitor disinformation trends in Taiwan and produces analysis reports for both English and Chinese audiences. Her English analyses are published in Taiwan FactCheck Center's biweekly newsletter "TFC Disinfo Detector."   Li received her Ph.D. degree at the Philip Merrill College of Journalism at the University of Maryland. Her research interests include propaganda, social media content moderation, free speech challenges faced by democratic countries, and privacy issues in the digital era. She has published scholarly articles in academic journals, books, and law reviews.   Before pursuing an academic career, she offered consulting services on digital human rights in Asia. She also worked as a journalist for media outlets in Taiwan for several years. She earned her LL.M. (Master of Laws) degree from the University of Pennsylvania Law School and has been admitted to the practice of law in New York State.   Here's a little preview of what we talked about in this podcast episode: ·       Wei-Ping's previous career in journalism that started in 2001 ·       How Wei-Ping was one of the speakers in a discussion about America Skepticism Theory organized by GTI (Global Taiwan Institute) ·       How Taiwan is currently the most free and democratic country in Asia ·       Taiwan has had the second longest period of martial law in world history, and a dark period of extreme censorship and authoritarianism during and after martial law was lifted in 1987 ·       The restrictions, and laws of Taiwan's martial law era included two tracks one was martial law and the other was called The Period of Mobilization for the Suppression of Communist Rebellion ·       The mechanisms that enforced the restrictions, and laws of Taiwan's martial law era, such as publishing laws, Article 100 of the Criminal Code and the Betrayers Punishment Act ·       Bans on the media, newspapers, songs, films, books ·       Why Mark Twain's book, The Adventures of Tom Sawyer and the wuxia novels of Jin Yong were previously banned in Taiwan ·       Some of the bureaus and departments that enforced censorship laws include: Taiwan Garrison Command, Information Bureau, Ministry of Education, Ministry of Interior, Council for Overseas Communities ·       How the Kuomintang extended their censorship to newspapers issued overseas ·       How private correspondence was monitored and surveilled ·       How the Kuomintang was trying to build a comprehensive mechanism of censorship in the 1950s ·       After martial law was lifted in Taiwan the government imposed a National Security Law ·       How it took the efforts of many advocates and advocates to break up the barriers and restrictions to gain more freedom ·       The Period of Mobilization Law was lifted in 1991by President Lee Teng-hui and the bans on newspapers were lifted in 1988 ·       How in 1989 (a year after bans on newspapers were lifted) Cheng Nan-jung, the publisher of the Freedom Era Weekly or New Era Weekly barricaded himself in his office and set himself on fire in protest against the restriction of media freedom ·       The nature of the bans on newspapers that were lifted ·       How Criminal Code Article 100 did not allow people to advocate for Taiwan independence, or criticize high ranking officials or presidents ·       The article written by Cheng Nan-jung in 1987 that criticized the authorities' methods of restricting freedom of speech ·       Topics that the Freedom Era Weekly addressed included the health of President Chiang Ching-kuo, power struggles inside the intelligence bureaus ·       The police that tried to arrest Chen Nan-jung on April 7, 1989 was headed by Hou You-yi, who is the KMT's presidential candidate for Taiwan's 2024 presidential election ·       How the Taiwan Independence Association led the repeal of the Betrayers Punishment Act, and amendment of Criminal Code Article 100 ·       In 1998 Taiwan's constitutional court made a decision that advocating for Taiwan independence is no longer a crime ·       How Taiwan's history has affected its media environment ·       The trauma of censorship on the Taiwanese ·       Taiwan's current media environment ·       Taiwan's ranking on the World Press Freedom Index ·       Challenges in Taiwan's current media environment ·       The self-censorship of businesses with close ties to China ·       How disinformation could flow into Taiwan through PTT (Taiwan's bulletin board system)   Related Links: https://talkingtaiwan.com/dr-wei-ping-li-how-taiwans-media-environment-changed-from-martial-law-era-to-present/

The 3CXDesktopApp is under exploitation in a supply chain campaign. An open letter asks for a pause in advanced AI development. All your grammar and usage are belong us. Combosquatting might fool even the wary. Defender had flagged Zoom and other safe sites as dangerous. Recognizing the importance of OSINT. Matt O'Neill from US Secret Service discussing his agency's cybersecurity mission. Our guest is Ping Li from Signifydwith a look at online fraud. And the FSB arrests a US journalist. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/61 Selected reading. 3CX DesktopApp Security Alert (3CX) Supply Chain Attack Against 3CXDesktopApp (CISA) Pause Giant AI Experiments: An Open Letter (Future of Life Institute) In Sudden Alarm, Tech Doyens Call for a Pause on ChatGPT (WIRED AI chatbots making it harder to spot phishing emails, say experts (the Guardian) The Most Common Combosquatting Keyword Is “Support” (Akamai) False positives in Microsoft Defender. (CyberWire) Exploitation is a Dish Best Served Cold: Winter Vivern Uses Known Zimbra Vulnerability to Target Webmail Portals of NATO-Aligned Governments in Europe (Proofpoint)  ESET Research Podcast: A year of fighting rockets, soldiers, and wipers in Ukraine (WeLiveSecurity)  Russia Ramping Up Cyberattacks Against Ukraine (VOA)  A new age of spying gives Kyiv the upper hand (The Telegraph)  Russia arrests Wall Street Journal reporter on spying charge (AP NEWS) Russia detains a Wall Street Journal reporter, accusing him of espionage. (New York Times)

This year has been painful for many businesses, but some tech-focused startups have managed to thrive amid the pandemic. In the $1B+ Club series debut, founder and CEO Klaviyo, Andrew Bialecki, shares how his marketing automation platform quintupled its valuation to $4.15B in the last 10 months. Ping Li, venture capitalist who led Accel’s investment in Klaviyo, discusses how Klaviyo joins a healthy cohort of e-commerce platforms, and highlights how Klaviyo has helped many struggling businesses pivot to online commerce after the pandemic closed their brick and mortar locations. Chinese regulators have ordered Ant Group, the world’s largest financial technology company, to rectify its businesses and comply with regulatory requirements amid increased scrutiny of anti-monopoly practices in the country’s internet sector. Plus, 11th hour changes to stimulus plans...and the most *intimate* holiday returns.  Learn more about your ad choices. Visit megaphone.fm/adchoices

We recognize the biases we hold around race, class, and gender, but what about language? Katherine Kinzler, author of the book, How You Say It: Why You Talk the Way You Do - and What It Says about You, explains, "The language you speak, and the accent or dialect you use to speak it, is such a foundational part of social life." Yet speech and language are often overlooked aspects of social identity. In fact, Katherine's research reveals that the way we speak can "determine who you might connect with, but also the judgments you make about other people, and the judgments they might be making about you." In her book, Katherine discusses how language, accents, and speech influence life experience and outcomes. In particular, they can be tools for social division, discrimination in hiring and firing, and other forms of bias and prejudice. It's one of the reasons Katherine advocates language learning in school. She says, "a lot of times, we think of language [learning] as 'icing on the cake'...nice to have but not really a fundamental part of learning. I think we could do so much more if we changed how we thought about the necessity of more than one language." Katherine Kinzler is Professor of Psychology at the University of Chicago. She holds degrees from Yale and Harvard, has written for the New York Times, and was recently named a Young Scientist by the World Economic Forum, one of the 50 scientists under 40 working to shape the future. Episode Links Bilingual Brains Better Equipped to Process Information  Neuroplasticity as a Function of Second Language Learning by Ping Li, Jennifer Legault, and Kaitlyn a. Litcofsky Want to be More Rational? Learn Another Language by Rob Smith How Speaking a Second Language Affects the Way You Think by David Ludden How Ruth Bader Ginsburg Found Her Voice by Katy Steinmetz Weird: The Power of Being an Outsider in an Insider World by Olga Khazan Meyer v. State of Nebraska Emotions Shape the Language We Use, but Second Languages Reveal a Shortcut around Them by Beth Daley The War against German-American Culture: The Removal of German-Language from Indianapolis Schools, 1917-1919 Linguistic Insecurity Bilingual Children's Social Preferences Hinge on Accent by Jasmine M. DeJesus, Hyesung G. Hwang, Jocelyn B. Dautel, and Katherine D. Kinzler The Native Language of Social Cognition by Katherine D. Kinzler, Emmanuel Dupoux, and Elizabeth S. Spelke Research: How Speech Patterns Lead to Hiring Bias by Michael W. Kraus, Brittany Torrez, and Jun Won Park Multilingual Environments Enrich Our Understanding of Others by Christopher Bergland Jane Elliott Ways to Support the Podcast If you're a fan of the show, there are three simple things you can do to support our work: Rate and review the podcast on iTunes or wherever you subscribe. This week, tell one person about the show. Subscribe so you never miss an episode. Where to Find Curious Minds Spotify iTunes Tunein Stitcher Google Podcasts Overcast Curious Minds Team Learn more about creator and host, Gayle Allen, and producer and editor, Rob Mancabelli, here.

Jane Ferguson:                  Hi there. Welcome to the November 2019 issue of Getting Personal: Omics of the Heart. I'm Jane Ferguson. This is your podcast from Circulation: Genomic and Precision Medicine. Let's get started.                                                 First up from Eric Curruth, Christopher Haggerty and colleagues from Geisinger, we have a paper entitled, “Prevalence and Electronic Health Record-based Phenotype of Loss-of-function Genetic Variance in Arrhythmogenic Right Ventricular Cardiomyopathy-associated Genes”. In this study, the team set out to understand the phenotypic consequences of variants and desmosome genes which has been associated with a arrhythmogenic right ventricular cardiomyopathy or ARVC. In clinical genetic testing, secondary findings of pathogenic or likely pathogenic variants in desmosome genes are recommended for clinical reporting. However, relatively little is known about the phenotypic consequences of these variants in a general clinical population.                                                 The team obtained whole exome sequencing data for over 61,000 individuals from the DiscovEHR cohort, part of the Geisinger MyCode Community Health Initiative. They then screened individuals for a putative loss of function variants in PKP2, DSC2, DSG2, and DSP. They evaluated ARVC diagnostic criteria using previously conducted ECG and echocardiograms and performed a phenom-wide association study or PHeWAS using EHR derived phenotypes. They found 140 people with an ARVC variant in one of the four genes, none of whom had an existing diagnosis of ARVC in the EHR.                                                 Further, there were no measurable differences in their ECG or echocardiogram findings compared with matched controls. There were also no associations with any heart disease phenotypes as assessed by PHeWAS. Overall, they report a prevalence of ARVC loss of function variants of around one in 435 in a general clinical population of predominantly European descent, but they did not find evidence that these variants associated with specific phenotypes. Thus, the clinical relevance of putative loss of function variants in desmosome genes still remains to be determined.                                                 The next paper is titled, “MRAS Variants Cause Cardiomyocyte Hypertrophy in Patients-specific iPSC-derived Cardiomyocytes”. Additional evidence for MRS as a definitive Noonan syndrome susceptibility gene. This comes from Erin Higgins, Michael Ackerman, and colleagues from the Mayo Clinic. They were interested in understanding whether a recently identified Noonan syndrome variant in the MRS gene was necessary and sufficient to cause Noonan syndrome with cardiac hypertrophy. They generated induced pluripotent STEM cell or IPS C lines from patient derived cells carrying the glycine 23 veiling variant and MRS. In addition to isogenic control cells where the pathogenic variant was corrected back to wild-type using CRISPR CAS nine gene editing, they also created a disease model cell line by introducing the MRS variant into unrelated control cells.                                                 They then comprehensively characterized the phenotypes of the three cell lines using a variety of approaches including microscopy, immunofluorescence, single cell RNA seek, Western blot, qPCR, and live cell calcium imaging. Both the patient derived and the disease model IPS cardiomyocytes were larger than control cells and demonstrated changes in gene expression and intracellular pathway signaling characteristic of cardiac hypertrophy. The patient and disease model cells also displayed impaired calcium handling. Through in-vitro phenotyping, the team was able to demonstrate that the glycine 23 veiling MRS variant elicits a cardiac hypertrophy phenotype and IPSC cardiomyocytes, that strongly suggests that this variant is responsible for the observed Noonan syndrome associated cardiac hypertrophy in the effected patients.                                                 Next up is a review from Christopher Lee, Iftikhar Kullo, and colleagues also from the Mayo Clinic on “New Case Detection by Cascade Testing in Familial Hypercholesterolemia: A Systematic Review of the Literature”. In this review they set out to systematically assess cascade testing programs for familial hypercholesterolemia, a disease which has a prevalence of about one and 250 but is estimated to be diagnosed in under 10% of patients. They identified published studies across the world which had conducted cascade testing and had reported the number of index cases and number of relatives tested and had also specified their methods of contacting relatives and testing.                                                 Using these criteria, they identified 10 studies for inclusion spanning several European countries, South Africa, New Zealand, Australia, and Brazil. The team calculated the proportion of relatives testing positive and the number of new cases per index case to facilitate comparison between studies. The mean number of programs was 242 with an average of 826 relatives per study. The average yield was 45%, ranging from 30 to 60%. the mean new cases per index case was 1.65 with a range of 0.22 to 8.0. Studies that use direct contact versus indirect contact for relatives and those that tested beyond first degree relatives had a greater yield. Further, active sample collection versus collection at clinic and using genetic testing versus biochemical testing was similarly associated with a higher yield. Despite differences between the United States and other countries, applying these strategies when establishing new cascade testing programs in the US may help promote success of these programs.                                                 Our next paper concerns “Randomization of Left-right Asymmetry and Congenital Heart Defects: The Role of DNAH5 in Humans and Mice”. And this was conducted by Tabea Nöthe-Menchen, Heymut Omran, and colleagues from University Children's Hospital Muenster and the PCD study group. They were interested in understanding the relationship between congenital heart defects and laterality defects where internal organs are atypically positioned, such as in a mirror image as occurs in situs inversus. Ciliary dyskinesia is thought to play a role in situs inversus and the most frequently mutated gene in primary ciliary dyskinesia is DNAH5. The team does hypothesize that DNAH5 mutations may play a role in congenital heart disease. They characterized phenotypes in 132 patients with primary ciliary dyskinesia carrying disease causing DNAH5 mutations and also studied left right access establishment using a DNAH5 mutant mouse model.                                                 66% of patients in their study had laterality defects, 88% of whom presented with situs inversus totalis and 6% presented with congenital heart disease. In the mass model, they observed immotile cilia, impaired flow with the left right organizer and randomization of nodal signaling with normal reversed or bilateral expression of key molecules. Their study thus demonstrates that mutation of DNAH5 is associated with congenital heart defects and they further highlight the ciliary mechanisms underlying defects and development of left right positioning during embryogenesis. Consideration of celiopathy related symptoms may be warranted when examining patients with congenital heart defects.                                                 Next up, we have a research letter from William Goodyear, Marco Perez and colleagues from Stanford University on “Broad Genetic Testing in a Clinical Setting Uncovers a High Prevalence of Titan Loss-of-Function Variants in Very Early-Onset Atrial Fibrillation”. They were interested in understanding genetic determinants of atrial fibrillation and hypothesized that causal genetic variants would be enriched in individuals with very early onset AF, who are diagnosed with AF under the age of 45 with no other significant comorbidities. They identified 25 families comprising 23 unrelated patients with very early onset AF who had been evaluated and received genetic counseling at Stanford between 2014 and 2018.                                                 The mean age of AF diagnosis was 27.2 years and 76% of patients were male. 40% of patients had a first or second degree relative with very early onset AF, while 36% at first or second degree relatives with either early onset idiopathic cardiomyopathy, unexplained sudden death or strokes. 85% of patients were identified as having at least one rare variant in a cardiomyopathy associated gene. Six patients carried actionable pathogenic or likely pathogenic variants, four of which were in the titan gene.                                                 A subset of individuals were further evaluated by MRI or computed tomography on average 817 days after their first presentation and this revealed high rates of cardiac abnormalities including reduced ventricular function, chamber enlargement, borderline LV non compaction, or late gadolinium enhancement. These were not noted on echocardiogram at presentation, suggesting there may have been subsequent disease development or progression. Overall, this study highlights a high rate of familial disease and implicates an association between very early onset AF and rare variants in titan before the clinical onset of cardiomyopathy.                                                 The final letter this month comes from Yu Xia, Shaoxian Chen, Ping Li, Jian Zhuang and colleagues from Guangdong Academy of Medical Sciences and is entitled, “A Novel Mutation in MYH6 in Two Unrelated Chinese Han Families with Familial Atrial Septal Defect”. They report on two unrelated families who presented with secundum atrial septal defect or ASD2. Whole exome sequencing revealed a novel variant and the MYH6 gene in both families, with the same variant present in all effected individuals but not in unaffected family members or unrelated controls. Because other variants in MYH6 have been reported to effect myofibril formation. The team studied the effect of the novel variant on the myofibrillar organization through transient transfection of CTC 12 cells. The MYH6 E526K variant was associated with a reduced striated I pattern and increased non-striated patterning. There was no effect on ATPase activity.                                                 Protein modeling suggested a variant of the effective position would reduce hydrogen bonding between alpha helices in the actin interface two region, increasing the volume of the cavity between the alpha helices and promoting the exposure of the alkaline side chain in the actin binding region. This could impair the interaction between the myosin motor head and actin. What these data suggests are that this novel MYH6 heterozygous variant may underlie ASD2 in two unrelated Chinese Han families by impairing myofibrillar organization.                                                 That's all for November 2019. Thank you for listening and I look forward to being back in December for the final episode of 2019.                                                 This podcast was brought to you by Circulation: Genomic and Precision Medicine and the American Heart Association council on genomic and precision medicine. This program is copyright American Heart Association 2019.

We kick off our investor series with Ping Li of Accel who was recently named the #2 investor in the Silicon Valley and is one of the most prominent investors in the security industry. We cover the biggest mistakes security companies make, how to successfully pitch your company to a veteran investor like Ping and we play an inaugural game of buzzword bingo to see if there's truly a market for that AI-powered blockchain idea you've been kicking around.

This conversation is about cybersecurity, which continues to make new headlines. Ping Li, a Accel partner, talks to Amit Yoran, the CEO of Tenable, to discuss the current state of affairs.

Cloudera Co-Founder Mike Olson shares his insights on the present landscape and possible future of big data and the data management industry. In conversation with Ping Li of Accel Partners, Olson also discusses the advantages of building a business on top of open source technologies and the many surprising benefits of competition.

Cloudera Co-Founder Mike Olson shares his insights on the present landscape and possible future of big data and the data management industry. In conversation with Ping Li of Accel Partners, Olson also discusses the advantages of building a business on top of open source technologies and the many surprising benefits of competition.

Cloudera Co-Founder Mike Olson shares his insights on the present landscape and possible future of big data and the data management industry. In conversation with Ping Li of Accel Partners, Olson also discusses the advantages of building a business on top of open source technologies and the many surprising benefits of competition.

Ping Li is a best-selling author, speaker, soul healer, inner transformation experts and creator of 22 steps of awakening to your divine essence. She helps spiritually seeking leaders, experts, coaches, and light workers who are ready to claim the power of their divine self, awakening their soul's infinite wisdom, tap into the source of their true being and the unlimited universe to take their personal and professional life to a new level of being, having and creating. Ping's book launch link: http://www.awakeningbooklaunch.com www.awakenwithinpath.com

Ping Li from Accel and Ashwin Navin, the President and Co-Founder of BitTorrent, Inc. talk about BitTorrent's journey from an open-source project to being a global standard for delivering high-quality files over the Internet. He discusses how their team worked on changing the landscape of digital media distribution. His company evolved to provide a revenue proposition to some of the largest media companies in the world. Navin mentions the company's plan of scaling internationally in countries like Japan as being key to its success in the future.