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CardioNerds (Drs. Rawan Amir, Tripti Gupta, and Alysha Joseph) discuss the fundamentals of adult congenital heart disease (ACHD) surgery with Dr. Elizabeth Stephens. Audio editing by CardioNerds academy intern, Grace Qiu. Using a case of a young adult undergoing a Ross procedure, the episode walks through what happens in the operating room—from induction and intraoperative transesophageal echocardiography (TEE) to cardiopulmonary bypass (CPB), myocardial protection, and surgical repair. The discussion highlights key concepts including cardioplegia, cross-clamp and bypass times, hypothermic circulatory arrest, and the complexity of redo sternotomy. This episode provides learners with a practical framework to interpret operative reports, anticipate postoperative physiology, and better collaborate with surgical teams. This episode was produced by the CardioNerds ACHD Council and planned by Dr. Rawan Amir. CardioNerds Adult Congenital Heart Disease PageCardioNerds Episode Page Pearls “LV distension kills patients.”Preventing left ventricular distension with appropriate venting and awareness of aortic insufficiency is critical to intraoperative safety. TEE can change the surgical plan in real time.Findings such as underestimated aortic regurgitation, mitral pathology, or a PFO may directly alter cannulation and cardioplegia strategy. Cross-clamp time = myocardial ischemic time; bypass time = systemic stress.Both are key predictors of postoperative complications including renal injury, bleeding, and ventricular dysfunction. Redo sternotomy risk is driven by anatomy, not just number.Aorta adherent to the sternum, conduit position, and chamber pressurization define risk more than the number of prior surgeries. Think longitudinally—ACHD surgery is lifetime planning.Surgical materials and strategies must account for future interventions, especially in younger patients. Notes: Notes drafted by Dr. Alysha Joseph, aided by generative artificial intelligence. What are the key steps in congenital cardiac surgery from incision to closure? Preoperative planning is multidisciplinary, involving surgeon, anesthesia, cardiology, and ICU teams; high-risk inductions (e.g., critical AS, Williams syndrome) are identified early TEE is performed immediately after induction to reassess anatomy and may reveal new findings (e.g., underestimated AI, mitral disease, PFO) Median sternotomy is performed, followed by creation of a pericardial well to optimize exposure Heparin is administered prior to cannulation; arterial and venous cannulas are placed for initiation of CPB Cross-clamp is applied and cardioplegia delivered to arrest the heart, allowing a still and protected operative field Surgical repair (e.g., Ross procedure) is performed, followed by de-airing, cross-clamp removal, and reperfusion Patient is weaned from bypass with TEE reassessment, hemostasis achieved, and chest closed What is cardioplegia and how is it delivered? Cardioplegia is a potassium-rich solution that arrests myocardial activity and reduces metabolic demand Most commonly used solution in the U.S. is Del Nido cardioplegia, originally developed for pediatric myocardium Delivery strategies include: Antegrade (via aortic root) – standard approach Ostial (direct coronary delivery) – used when aortic root cannot be relied upon Retrograde (via coronary sinus) – useful in severe AI or coronary disease NOTE: Severe aortic regurgitation can impair antegrade delivery and requires alternative strategies and LV venting What do cross-clamp time and bypass time represent clinically? Cross-clamp time = duration of myocardial ischemia while the heart is arrested Bypass time = total duration on CPB, reflecting systemic exposure to non-physiologic circulation Prolonged cross-clamp time (>2–3 hours) increases risk of myocardial dysfunction, especially with poor baseline function Longer bypass time is associated with increased risk of renal injury, coagulopathy, and bleeding These metrics often reflect both case complexity and intraoperative challenges What is hypothermic circulatory arrest (HCA) and when is it used? HCA involves complete cessation of blood flow to allow a bloodless surgical field Typically used in complex aortic arch repairs Patients are cooled to ~18°C to reduce metabolic demand and protect organs Duration is ideally limited to
Ariane Baujard est cofondatrice de LÏV Happy Food, marque pionnière du konjac en France.Quand elle se lance, elle cumule deux défis que le marché n'est pas prêt à lui faciliter : faire connaître un produit que la France ne connaît pas encore, et s'attaquer à la grande distribution en arrivant des cosmétiques. Apprendre les codes de ce secteur, dit-elle, c'est comme apprendre une langue étrangère : seule, à force d'erreurs et de patience.En 7 ans, LÏV s'est imposée chez Monoprix, Carrefour, Intermarché, Franprix, Auchan, Leclerc, mais aussi en Suisse, en Belgique et en Italie. Sans levée de fonds, avec une patience stratégique forgée dans un environnement souvent brutal, et une conviction intacte : "Non n'est pas une réponse, ça signifie peut-être demain."Dans cet épisode, Ariane parle aussi du burn-out, ce moment où le corps décide à votre place quand on refuse de s'arrêter, et de ce qu'il a transformé dans sa façon d'entreprendre et de se construire.Un épisode dense et sincère sur les dessous de la grande distribution, la construction d'une marque alimentaire sans filet, et ce qu'on apprend quand on refuse d'abandonner, et quand on n'a plus le choix que d'arrêter.Bonne écoute !Pour participer aux événements BWP, rdv sur businesswomeninparis.com, @businesswomeninparis et inscrivez-vous à la newsletter.Titre : Not KingsAuteur : Candy SaysSource : https://candysays.bandcamp.com/Licence : https://creativecommons.org/licenses/by-sa/3.0/deed.frTéléchargement : https://auboutdufil.com/?id=561Hébergé par Ausha. Visitez ausha.co/fr/politique-de-confidentialite pour plus d'informations.Hébergé par Ausha. Visitez ausha.co/fr/politique-de-confidentialite pour plus d'informations.Hébergé par Ausha. Visitez ausha.co/fr/politique-de-confidentialite pour plus d'informations.Hébergé par Ausha. Visitez ausha.co/fr/politique-de-confidentialite pour plus d'informations.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Tiekamies ar mednieku Jāni Brambatu, kurš dalās savā stāstā par tiesvedību, kas nu jau četrus gadus neļauj viņam iet medībās ar saviem šaujamieročiem. Pamatoti, nepamatoti - par to spriediet paši. Bet šeit stāsts par Ieroču aprites likumu, ārkārtīgi lēno tiesu sistēmu un daudzām citām problēmām! Konkursa jautājums no OUTDOOREXPERTS.LV: https://outdoorexperts.lv/lv/Pievienojieties šim kanālam, lai iegūtu piekļuvi privilēģijām.https://www.youtube.com/channel/UCqB3nyhYHXKobopia9d7xgA/join
Sau cuộc biểu tình chống thuế ở Huế, Nguyễn Tất Thành chiêm nghiệm với thầy Lê Văn Miến rằng: Lòng yêu nước là chưa đủ, muốn cách mạng thành công bắt buộc phải có tổ chức, người lãnh đạo và phương pháp đúng đắn. Tư duy sắc sảo, thực tế này đã làm người thầy vô cùng cảm động và đặt trọn niềm tin vào thế hệ trẻ.
ReferencesJ Pineal Res. 2017 Sep 6;63(4):e12440Nature Reviews | Cancer Reviews2019. 19 | AUGUST 2019 :pp. 439J Exp Clin Cancer Res 2022. 41, 268.Front. Genet., 11 March 2015 Sec. Cancer Genetics Volume 6 - 2015 | https://doi.org/10.3389/fgene.2015.00094 Pathol Oncol Res 2022 Aug 19:28:1610401Guerra, DJ.2026.Unpublished LecturesPorter, C. I1944. Love You Bing Crosbyhttps://music.youtube.com/watch?v=U2Ehu42-mik&si=tkpg8dJxk2TdBvQPAhlert and Turk. 1928. 1944 I'll Get By. Harry James and Orchestrahttps://music.youtube.com/watch?v=8KhO3g5kY0c&si=fXWDc4ZheJ658A1xBeethoven, LV. 1804. Symphony V. C Minor Op 67https://music.youtube.com/watch?v=q_kw904K2bw&si=qDRCnK5UVDi1-9w2
Tại trường Pháp - Việt ở Huế, Tất Thành tiếp tục được thầy Lê Văn Miến giải đáp những thắc mắc về lịch sử, chính trị và xã hội. Qua câu chuyện về khẩu hiệu tự do - bình đẳng - bác ái, thầy phân tích cho Thành hiểu bản chất của chế độ phong kiến Việt Nam, chính sách cai trị của thực dân Pháp và ý nghĩa to lớn của cách mạng Pháp năm 1789.
Lv.213配信です。今回の「BabySteps」についてのネタバレ感想トークです。苦行ゲーとどこからともなく聞いておりましたが、実際に遊んでみるとなんとも形容しがたい感情を2人揃って抱いておりました。BabySteps、オススメです。しんどいけど
Vēl pirms dažiem gadiem mākslīgā intelekta radīti dziļviltojumi jeb "deepfakes" šķita drīzāk tehnoloģiju pasaules kuriozs, taču mākslīgā intelekta rīku straujā attīstība ļauj krāpniekiem ļoti reālistiski klonēt cilvēka balsi un seju, un pat imitēt to video zvanā. Mākslīgā intelekta dziļviltojumi no izklaides ir pārtapuši par nopietnu kiberdrošības apdraudējumu, kas ietekmē pat sabiedrības procesus. Pie Digitālo brokastu galda CERT.LV kiberdrošības eksperts Mārtiņš Vecstaudžs un privātās izlūkošanas aģentūras “Rossad” direktors Madars Balodis. Plašāk par tehnoloģiju jaunumiem lasi arī LSM portālā.
VOV1 - Tỉnh Quảng Ngãi đang ứng dụng radar xuyên đất để khoanh vùng, xác định các vị trí nghi có hài cốt liệt sĩ tại khu vực đường Trường Chinh, nơi tiếp giáp giữa phường Kon Tum và phường Đăk Cấm (thành phố Kon Tum cũ) trước khi triển khai tìm kiếmSáng 4/6, Bộ Chỉ huy Quân sự tỉnh Quảng Ngãi phối hợp với Trường Đại học Khoa học Tự nhiên (Đại học Quốc gia Thành phố Hồ Chí Minh) sử dụng thiết bị radar xuyên đất khảo sát khu vực đường Trường Chinh, phường Đăk Cấm nhằm xác định các dấu hiệu khả nghi dưới lòng đất, phục vụ công tác tìm kiếm hài cốt liệt sĩ.Tại hiện trường, các chuyên gia tiến hành quét radar những khu vực nghi có rãnh chôn cất liệt sĩ dựa trên các nguồn tư liệu, kết quả nghiên cứu và thông tin nhân chứng đã được thu thập, đối chiếu. Thiết bị radar hoạt động bằng cách phát sóng điện từ xuống lòng đất và thu nhận tín hiệu phản xạ trở lại, từ đó tạo ra các lát cắt địa chất giúp nhận diện cấu trúc và những dấu hiệu khả nghi bên dưới bề mặt. Ông Lê Văn Anh Cường, Trưởng bộ môn Vật lý Địa cầu, Trường Đại học Khoa học Tự nhiên cho biết:“Máy radar này sử dụng sóng điện từ lan truyền trong lòng đất và nhận các sóng phản xạ trở lại. Từ đó, chúng tôi sẽ có các lát cắt sóng điện từ. Từ những lát cắt này, chúng ta sẽ diễn giải để có thể thấy được các cấu trúc bên dưới mặt đất. Những thông tin liên quan đến hố chôn liệt sĩ có thể được phản ánh qua các dạng ảnh radar mà chúng ta thu nhận được”.Các chuyên gia tiến hành quét radar ở những khu vực nghi có rãnh chôn cất liệt sĩ.
Latvijas metāla jaunās relīzes - 2026. gada 1. ceturksnis un 2025. gada 2.-4. ceturkšņi (iekavētie) - METĀLKĀSTS LV #196Šajā epizodē sākam 2026. gada ceturkšņu ciklu, atskatoties uz jaunākajām Latvijas smagās mūzikas relīzēm un nokārtojam savus parādus, iekļaujot nokavētos 2025. gada ceturkšņus (2.-4. ceturkšņus - relīzes no aprīļa līdz decembrim).Kā jau ierasts, atskatoties uz aizgājušo ceturksni, apspriežam un uzskaitām visas LV smagās mūzikas relīzes, kuras tika izdotas aizgājušajā ceturksnī (janvārī, februārī, martā). Šoreiz būs arī neliels bunkura hroniku piesitiens, jo sērijā ietveram tādas tēmas, kā aizgājušie un gaidāmie koncerti, Silvestra dzejas vakars, kolekcijas papildinājumi, u.c. tēmas. Izsakām savus viedokļus gan nopietni, gan caur jokiem!Kas no jaunizdotā Lavijas metāla tev visvairāk ir palicis atmiņā?Kādas relīzes pieminētajos ceturkšņos esam palaiduši garām?Ja vēlies lai tavu jaunizdoto metālmūziku nepalaižam garām un pieminam nākamajā ceturkšņa sērijā, droši dod mums ziņu!Saites uz pieminētajām relīzēm atrodamas google sheets saitē.2025. gada 2.-4. ceturkšņu relīzes:https://docs.google.com/spreadsheets/...2026. gada 1. ceturkšņa relīzes:https://docs.google.com/spreadsheets/...0:00 - Ievads2:52 - Dödsrit koncerta atskats7:49 - Epizodes mērķis un attaisnojumi13:55 - Folk metāls (25.g. iekavētie ceturkšņi)17:37 - Black metāls (25.g. iekavētie ceturkšņi)25:07 - Dark/Ambient/Dungeon (25.g. iekavētie ceturkšņi)28:53 - Ekstrēmais Post metāls (25.g. iekavētie ceturkšņi)36:24 - Thrash un Heavy metāls (25.g. iekavētie ceturkšņi)38:22 - Death metāls (25.g. iekavētie ceturkšņi)41:38 - Gaidāmais koncerts Rēzeknē 1/243:49 - Doom metāls (25.g. iekavētie ceturkšņi)46:56 - Metalcore/Deathcore/HC (25.g. iekavētie ceturkšņi)50:05 - Nu/Groove metāls (25.g. iekavētie ceturkšņi)51:58 - Punk/Random (25.g. iekavētie ceturkšņi)53:04 - Prog/Epic metāls (25.g. iekavētie ceturkšņi)53:36 - Gore/Grind/Miglinieks (25.g. iekavētie ceturkšņi)56:23 - Rock/Grunge (25.g. iekavētie ceturkšņi)58:18 - Aizgājušo koncertu atskats1:18:19 - Silvestra dzejas vakars1:21:40 - Mizantropium vakance1:22:37 - Ievadpauze 2026.g. 1. ceturksnim1:24:32 - Black metāls (26.g. 1. ceturksnis)1:33:23 - Dark/Ambient/Acoustic (26.g. 1. ceturksnis) 1/21:35:47 - Gaidāmais koncerts Rēzeknē 2/21:37:06 - Dark/Ambient/Acoustic (26.g. 1. ceturksnis) 2/21:40:25 - Doom metāls (26.g. 1. ceturksnis)1:43:45 - Post metāls (26.g. 1. ceturksnis)1:45:08 - Metalcore/Modernais metāls (26.g. 1. ceturksnis)1:50:07 - Nu metāls (26.g. 1. ceturksnis)1:54:30 - Hardcore (26.g. 1. ceturksnis)1:56:05 - Thrash metāls (26.g. 1. ceturksnis)1:57:00 - Gore/Grind/Random (26.g. 1. ceturksnis)1:59:43 - Heavy/Power/Epic metāls (26.g. 1. ceturksnis)2:01:22 - Rock/Grunge/Post (26.g. 1. ceturksnis)2:03:35 - Ceturkšņa atskata noslēdzošie vārdi (Silvestra atvadas)2:05:12 - 2026.g. gaidāmie koncerti un festivāli2:25:28 - MLV plāni un noslēguma vārdi2:30:04 - Ocularis Infernum "Strife and Ascendance" atskaņojumsSEKO Metālkāstam: / metalkastslv Tagad esam arī Instagramā: / metalkastslv Būsim priecīgi par tavu atbalstu un iesaistīšanos mūsu atbalstītāju grupā:https://ko-fi.com/metalkastslvMetālkāsts LV ir podkāsts latviešu valodā smagās mūzikas cienītājiem. Pasākumu un albumu apskati, sarunas/intervijas, vietējās metālmūzikas jaunumi, un citas smagās sarunas m/
Lv.212配信です。今回は先日おたより募集をさせていただきました「キングダムハーツ３ぶっちゃけ感想」がテーマです。褒めていない箇所も多分にありますが、キングダムハーツ３は非常に惜しいなと思うタイトル。素晴らしいと思える箇所もたくさん。たまたまなのかもしれませんが…リスナーさんのおたよりもある程度似通った感想でした笑。 #感想 #レビュー #解説 #考察 #ポッドキャスト//// グッズ販売中！ ///////////////PodcastWeekend2026用に作成しました番組オリジナルグッズをBOOTHにてオンライン販売します。在庫限りとなりますのでぜひお早めにお求めください。※購入いただいた方にはゲーム系ポッドキャスト トレカをおまけとして同梱いたしますので、そちらもぜひご覧ください。BOOTH｜https://gamenantoka.booth.pm/ //// キーワード ///////////////ドラクエ12／Switch2／ぽこあポケモン／BABYSTEPS／OPUS: Prism Peak／キングダムハーツ３／FF15//// 出演 ///////////////こへい／HARU //// チャプター ///////////////(00:00:00) ｜オープニング(00:00:58) ｜OP／ドラゴンクエスト12(00:06:34) ｜OP／こへい家Switch2購入(00:17:06) ｜OP／BABYSTEPS(00:19:40) ｜OP／OPUS: Prism Peak(00:32:38) ｜本編／キングダムハーツ３のぶっちゃけ感想回(01:37:20) ｜エンディング //// 番組へのおたより ///////////////番組へのおたより・メッセージは番組ウェブサイト（ https://gamenantoka.com/ ）または gamenantoka@gmail.com へお送りください。 //// 番組YouTubeチャンネル ///////////////ゲームなんとかの今後の活動の幅を広げるため、さらなる番組リスナーさん増加を目指してYouTubeチャンネルを開設しました。ポッドキャストと同じ音源を配信だけではなく、動画ならではの取り組みも挑戦していこうかと思いますので、ぜひともチャンネル登録をお願いいたします。https://www.youtube.com/c/gamenantoka //// その他 ///////////////■ 番組の感想には #ゲームなんとか をお気軽にお使いください！■ X：@gamenantoka
LAUDES VIERNES DE LA IV SEMANA DE ORDINARIO(Oración de la mañana) - lV semana del SalterioINVOCACIÓN INICIALV. Señor abre mis labiosR. Y mi boca proclamará tu alabanzaINVITATORIOAnt. El Señor es bueno, bendecid su nombre.SALMODIASalmo 50 - Ant.Oh Dios, crea en mi un corazón puro, renuevame por dentro con espiritu firme.Cántico - Ant. Alégrate, Jerusalén, porque en ti serán congregados todos los pueblos.Salmo 147 - Ant. Síon, alaba a tu Dios, que envía su mensaje a la tierra.CÁNTICO EVANGÉLICOAnt. Por la entrañable misericordia de nuestro Dios, nos visitara el sol que nace de lo alto.Cántico de Zacarías. EL MESÍAS Y SU PRECURSOR Lc 1, 68-79Bendito sea el Señor, Dios de Israel,porque ha visitado y redimido a su pueblo.suscitándonos una fuerza de salvaciónen la casa de David, su siervo,según lo había predicho desde antiguopor boca de sus santos profetas:Es la salvación que nos libra de nuestros enemigosy de la mano de todos los que nos odian;ha realizado así la misericordia que tuvo con nuestros padres,recordando su santa alianzay el juramento que juró a nuestro padre Abraham.Para concedernos que, libres de temor,arrancados de la mano de los enemigos,le sirvamos con santidad y justicia,en su presencia, todos nuestros días.Y a ti, niño, te llamarán Profeta del Altísimo,porque irás delante del Señora preparar sus caminos,anunciando a su pueblo la salvación,el perdón de sus pecados.Por la entrañable misericordia de nuestro Dios,nos visitará el sol que nace de lo alto,para iluminar a los que viven en tinieblay en sombra de muerte,para guiar nuestros pasospor el camino de la paz.Gloria al Padre, y al Hijo, y al Espíritu Santo.Como era en el principio, ahora y siempre, por los siglos de los siglos. Amén.PRECES“Escucha, Señor, y ten piedad.”ConclusionV. El Señor nos bendiga, nos guarde de todo mal y nos lleve a la vida eterna.R. Amén.(328)
ReferencesBarnie, Juliana.2025. The Impact of Estrogen Loss on CaveolinExpression and Cardiac Myocyte Remodeling in Ovariectomized Mice Following Chronic Sympathetic Stimulation" East Tennessee State University MS ThesisSeminars in Cell and Developmental Biology May 2019 98(4)Am J. Physiology/Cell Physioloy.2007.Volume 293, Issue 6Methods Mol Bio. 2006:332:181-91. Cells 2022, 11(23), 3850; Guerra, DJ. 2026. Unpublished Lectures.Capaldi/Winwood. 1971. Low Spark of High Hell Boys Traffic https://open.spotify.com/track/1yW6y8RufwB4WEAQeip0tx?si=6fd9c8119343492b Beethoven, LV. 1812. Symphony 7.in A major. OP 92. https://music.youtube.com/watch?v=Rd0HnxWm5CY&si=jrDwV4F6Cy6SUjA1
VOV1 - Bộ Tài chính vừa trình Chính phủ dự thảo Nghị định quy định chi tiết một số điều và biện pháp tổ chức thực hiện Luật Thuế thu nhập cá nhân số 109/2025. Ông Lê Văn Tuấn, Giám đốc Công ty Kế toán Thuế Keytas cùng bàn luận.Theo tờ trình dự thảo, Bộ Tài chính đã chính thức đề xuất cho phép người nộp thuế được khấu trừ thêm các khoản chi phí về y tế, giáo dục và đào tạo, trước khi xác định thu nhập tính thuế.Việc bổ sung các danh mục chi phí thiết yếu này được kỳ vọng sẽ tạo ra cơ chế quản lý thuế nhân văn và sát thực tế hơn. Bên cạnh đó, chuyên gia thuế cũng tiếp tục kiến nghị một số sửa đổi, bổ sung hoàn thiện quy định về quản lý thuế theo đúng chủ trương cải cách, giảm thu tục hành chính cho người dân.Những điểm mới trong Dự thảo Nghị định hướng dẫn Luật thuế thu nhập cá nhân
LAUDES MIERCOLES DE LA XXIV SEMANA DE ORDINARIO(Oración de la mañana) - lV semana del SalterioINVOCACIÓN INICIALV. Señor abre mis labiosR. Y mi boca proclamará tu alabanzaINVITATORIOAnt. Aclama al Señor, tierra entera, servid al Señor con alegría.SALMODIASalmo 107 - Ant. Mi corazón está firme, Dios mío, mi corazón está firme. Cántico - Ant. El Señor me ha revestido de justicia y santidad.Salmo 145 - Ant. Alabare al Señor mientras viva.CÁNTICO EVANGÉLICOAnt. Sirvamos al Señor con santidad todos nuestros días. Cántico de Zacarías. EL MESÍAS Y SU PRECURSOR Lc 1, 68-79Bendito sea el Señor, Dios de Israel,porque ha visitado y redimido a su pueblo.suscitándonos una fuerza de salvaciónen la casa de David, su siervo,según lo había predicho desde antiguopor boca de sus santos profetas:Es la salvación que nos libra de nuestros enemigosy de la mano de todos los que nos odian;ha realizado así la misericordia que tuvo con nuestros padres,recordando su santa alianzay el juramento que juró a nuestro padre Abraham.Para concedernos que, libres de temor,arrancados de la mano de los enemigos,le sirvamos con santidad y justicia,en su presencia, todos nuestros días.Y a ti, niño, te llamarán Profeta del Altísimo,porque irás delante del Señora preparar sus caminos,anunciando a su pueblo la salvación,el perdón de sus pecados.Por la entrañable misericordia de nuestro Dios,nos visitará el sol que nace de lo alto,para iluminar a los que viven en tinieblay en sombra de muerte,para guiar nuestros pasospor el camino de la paz.Gloria al Padre, y al Hijo, y al Espíritu Santo.Como era en el principio, ahora y siempre, por los siglos de los siglos. Amén.PRECES“Rey de la gloria, escuchanos.”ConclusionV. El Señor nos bendiga, nos guarde de todo mal y nos lleve a la vida eterna.R. Amén.(324)
Last week we took on the landmark Ridley Scott movie, Alien, a movie that closed out the 1970's with a bang. This week we're taking on James Cameron and his follow-up to the explosive 1985 smash hit, The Terminator, Aliens. Cameron knew he wanted to make an Alien sequel the moment he first saw the original movie and when the opportunity arose he had to fight tooth and nail, struggling against 20th Century Fox's bad business and legal woes, against apathetic executive who had no interest whatsoever in making another Alien movie, against a production crew that couldn't stand him or his producer Gale Anne Hurd. When all was said and done and the movie hit theaters, Cameron proved to everyone what absolute losers they all were with his clear vision of an explosive action movie that set the pace for the second half of the 80's and set an extremely high bar for action movies to come. Hollywood would never be the same and with the inclusion of the Colonial Marines, Cameron set the entire Alien legacy on a new path. Following the tragedy of the Nostromo disaster Ellen Ripley finds herself waking up 57 years in the future. Her bosses are pissed that she blew up one of their space ships and ban her from flying another mission. An opportunity to get back on a starship comes around when an executive from Weyland Yutani hires her to return to LV-426 to advise a unit of Colonial Marines on a rescue mission of missing colonists who may have come into contact with the same crashed alien ship that doomed her own crew so many years ago. She had enough trouble dealing with one single xenomorph. What happens when the Colonial Marines encounter dozens of them? Get Physical Media Booklet Essay featuring Dave's Werewolf Women of the SS essay here: https://www.seanabley.com/store/ Get your own Bring Me The Axe! Pride shirt here: https://www.bonfire.com/wickedqueeraxe/ Join the Bring Me The Axe Discord: https://discord.gg/snkxuxzJ Support Bring Me The Axe! on Patreon:https://patreon.com/bringmetheaxepod Buy Bring Me The Axe merch here: https://www.bonfire.com/store/bring-me-the-axe-podcast/
Lv.211配信です。今回はおたより紹介。ハイパフォーマンスコントローラーの話やぽこあポケモンの巨大HARU像の建造秘話などさまざまお話しております！ #感想 #レビュー #解説 #考察 #ポッドキャスト//// グッズ販売中！ ///////////////PodcastWeekend2026用に作成しました番組オリジナルグッズをBOOTHにてオンライン販売します。在庫限りとなりますのでぜひお早めにお求めください。※購入いただいた方にはゲーム系ポッドキャスト トレカをおまけとして同梱いたしますので、そちらもぜひご覧ください。BOOTH｜https://gamenantoka.booth.pm/ //// キーワード ///////////////STARFOX／BABYSTEPS／スペルトナエル／PodcastWeekend2026／ハイパフォーマンスコントローラー／Witch the Showdown／ぽこあポケモン 巨大HARU像//// 出演 ///////////////こへい／HARU //// チャプター ///////////////(00:00:00) ｜オープニング(00:00:53) ｜OP／StarFoxダイレクト(00:17:59) ｜OP／BABYSTEPS(00:22:06) ｜OP／スペルトナエル(00:35:09) ｜本編／おたよりをなんとか(01:17:05) ｜エンディング //// 番組へのおたより ///////////////番組へのおたより・メッセージは番組ウェブサイト（ https://gamenantoka.com/ ）または gamenantoka@gmail.com へお送りください。 //// 番組YouTubeチャンネル ///////////////ゲームなんとかの今後の活動の幅を広げるため、さらなる番組リスナーさん増加を目指してYouTubeチャンネルを開設しました。ポッドキャストと同じ音源を配信だけではなく、動画ならではの取り組みも挑戦していこうかと思いますので、ぜひともチャンネル登録をお願いいたします。https://www.youtube.com/c/gamenantoka //// その他 ///////////////■ 番組の感想には #ゲームなんとか をお気軽にお使いください！■ X：@gamenantoka
Vēlme pēc "vieglas naudas" nereti beidzas ar iekļūšanu krāpniecības shēmā. 2025. gadā tie bija 479 investīciju krāpšanu gadījumi, kuros iedzīvotāji zaudēja vairāk nekā 6,7 miljonus eiro. Kāpēc nonākam šādās situācijās un kurā brīdī zaudējam modrību un spēju kritiski izvērtēt riskus? Raidījumā Kā labāk dzīvot analizē kibernoziegumu pētnieks, programmētājs Elviss Strazdiņš, Latvijas Bankas Finanšu pratības daļas vadītāja Aija Brikše un kiberincidentu novēršanas institūcijas CERT.LV kiberdrošības eksperts Gints Mālkalnietis. Elviss Strazdiņš stāsta par pēdējā laika krāpnieku aktivitātēm, cenšoties izkrāpt līdzekļus, uzdodoties par bankas vai dažādu pakalpojumu sniedzēju pārstāvjiem un pārliecinot cilvēkus, ka tūlīt ir jāveic kādas darbības, pieslēdzoties interneta bankai, lai it kā pasargātu savus ietaupījumus. "Līdzko sākas runa par naudu, jāsaprot, ka jūs esat tas, kas izlemj, kam dot, kam un kāpēc naudu skaitīt," atgādina Gints Mālkalnietis. "Līdz ar to policija neprasīs ņemt izņemt naudu; tāpat neprasīs banka izņemt naudu; nebūs kontu glābšana, pārvietojot naudu uz "Omniva" pakomātu nakts vidū. Tas ir tiešām reāls stāsts." "Es ieteiktu ļoti kritiski izvērtēt! Tā ir jūsu naudu, jūs negribat to uzdāvināt kādam. Saprotiet, kur un kāpēc jūs to nesat, dodat, jo krāpnieki cenšas pirmām kārtām samulsināt jūs ar to, ka viņi pārstāv policiju, bet viņi teiks, ka uz policiju zvanīt nevarat, tāpēc, ka tā ir slepena operācija," turpina Gints Mālkalnietis. "Otrkārt, izdomās kaut kādas neesošas iestādes. Viņu galvenais mērķis ir panākt, lai jūs padomājiet, ka jums ir kaut kāds pārkāpums, vai kaut kāds uzbrukums; ka jūs esat tas, kas ar viņu palīdzību situāciju atrisinās. Lai gan jums nekādas problēmas pirms tam nav bijušas, jūs nezināt ne par kādiem viltus darījumiem, ne jūsu kontā būtu parādījusies vai pazudusi nauda. Jūs kontrolējat savu kontu, nedariet tanī neko, ko lūdz kāds cits."
Lv.210配信です。今回のテーマは「ボクたちの格ゲー遍歴」。さほど格ゲーにくわしくない２人が過去に遊んでいた格ゲーについてアレコレ話しています。 #感想 #レビュー #解説 #考察 #ポッドキャスト//// グッズ販売中！ ///////////////PodcastWeekend2026用に作成しました番組オリジナルグッズをBOOTHにてオンライン販売します。在庫限りとなりますのでぜひお早めにお求めください。※購入いただいた方にはゲーム系ポッドキャスト トレカをおまけとして同梱いたしますので、そちらもぜひご覧ください。BOOTH｜https://gamenantoka.booth.pm/ //// キーワード ///////////////PodcastWeekend2026／ジョイメカファイト／ストリートファイター／KOF／餓狼伝説／幽遊白書／スーパー武闘伝／闘神伝／鉄拳／ポッ拳//// 出演 ///////////////こへい／HARU //// チャプター ///////////////(00:00:00) ｜オープニング(00:00:55) ｜OP／Podcast Weekend 2026御礼(00:03:31) ｜OP／グッズ販売お知らせ(00:16:39) ｜OP／Podcast Weekend 2026振り返り(00:35:26) ｜本編／格ゲー遍歴をなんとか(01:27:28) ｜エンディング //// 番組へのおたより ///////////////番組へのおたより・メッセージは番組ウェブサイト（ https://gamenantoka.com/ ）または gamenantoka@gmail.com へお送りください。 //// 番組YouTubeチャンネル ///////////////ゲームなんとかの今後の活動の幅を広げるため、さらなる番組リスナーさん増加を目指してYouTubeチャンネルを開設しました。ポッドキャストと同じ音源を配信だけではなく、動画ならではの取り組みも挑戦していこうかと思いますので、ぜひともチャンネル登録をお願いいたします。https://www.youtube.com/c/gamenantoka //// その他 ///////////////■ 番組の感想には #ゲームなんとか をお気軽にお使いください！■ X：@gamenantoka
VOV1 - Sáng 15/5, tại Học viện Cảnh sát nhân dân, Bộ Công an phối hợp với Hội đồng Lý luận Trung ương tổ chức Hội thảo khoa học cấp quốc gia “Phong trào thi đua Ba nhất - Động lực cốt lõi xây dựng lực lượng Công an nhân dân cách mạng, chính quy, tinh nhuệ, hiện đại”. Hội thảo nhằm làm sâu sắc hơn cơ sở lý luận và thực tiễn của phong trào thi đua yêu nước trong Công an nhân dân; đồng thời khẳng định giá trị, sức lan tỏa và vai trò động lực của phong trào thi đua “Ba nhất” trong thực hiện thắng lợi nhiệm vụ bảo vệ an ninh quốc gia, bảo đảm trật tự, an toàn xã hội trong giai đoạn mới nói chung và xây dựng lực lượng Công an nhân dân cách mạng, chính quy, tinh nhuệ, hiện đại nói riêng. TS, Thượng tướng Lê Văn Tuyến, Ủy viên Trung ương Đảng, Thứ trưởng Bộ Công an và GS. TS Lê Văn Lợi, Ủy viên Trung ương Đảng, Chủ tịch Viện Hàn lâm Khoa học xã hội Việt Nam, Phó Chủ tịch Hội đồng Lý luận Trung ương chỉ đạo hội thảo
This week we rub our lamps and see what comes out. Except we know what comes out. Infinite juice. Five of them to be exact. We also talk about Dan being banned from LV, finally a positive instagram poster and whether or not something can be in eyeshot or earline. Fascinating stuff.You can contact us via email at lesoderants@gmail.com or via Instagram: Dan: fragrance_weirdoJames: houdini_sotd Ben: talking_scents Fliss: fliss_sniffs_stuff
Become a Big Dog Member here: https://bdge.co/memberships/fantasy_football/pricing0:00 - it's rude to skip intros0:24 - bijan robinson, RB, ATL (pick #1)2:41 - jahmyr gibbs, RB, DET (pick #2)5:18 - puka nacua, WR, LAR (pick #3)5:48 - jaxon smith-njigba, WR, SEA (pick #4)7:30 - ja'marr chase, WR, CIN (pick #5)9:15 - christian mccaffrey, RB, SF (pick #6)10:50 - jonathan taylor, RB, IND (pick #7)12:18 - amon-ra st. brown, WR, DET (pick #8)12:41 - ceedee lamb, WR, DAL (pick #9)14:20 - james cook, RB, BUF (pick #10)17:19 - justin jefferson, WR, MIN (pick #11)19:54 - saquon barkley, RB, PHI (pick #12)21:20 - ashton jeanty, RB, LV (honorable mention)subscribe to the bdge dynasty channel: https://ytube.io/3pZklisten to the bdge dynasty podcast: https://bityl.co/NzJ1bdge nfl trivia youtube channel: https://ytube.io/3jmJjoin the BDGE discord: https://discord.gg/77BxrqCF6Fsubscribe to the BDGE podcast | https://linktr.ee/bdgefollow me on the socials | https://linktr.ee/nickercolanoContact▪️ business inquiries | business@bdge.co▪️ customer support/help | help@bdge.co▪️ fantasy questions can go in our discord | https://discord.gg/AvpY3QJTAythis video is about (bdge,nick ercolano,fantasypros,fantasy flock,fantasy footballers,bdge fantasy football,fantasy football mock draft,2026 fantasy football,2026 fantasy football draft,2026 fantasy football mock draft)Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Ngày 11-5: Thánh Mát-thêu Lê Văn Gẫm, Thương gia (+1847), Tử đạo by TGP Hà Nội
Lv.209配信です。今回のテーマは番組宛にディベロッパー、パブリッシャーからメッセージを貰った3タイトルを実際に遊んでみて…というところでの感想トークです。 #感想 #レビュー #解説 #考察 #ポッドキャスト //// キーワード ///////////////PODCASTWEEKEND2026／BABYSTEPS／獣道10先／Point In Time／Witch the Showdown／PAIC：ムーンライダー物語//// 本編トークの3本 ///////////////Point In Timehttps://store.steampowered.com/app/4016500/Point_In_Time/Witch the Showdownhttps://store.steampowered.com/app/3103620/Witch_the_Showdown/?l=japanesePAIC：ムーンライダー物語https://store.steampowered.com/app/4492120/PAIC///// 出演 ///////////////こへい／HARU //// チャプター ///////////////(00:00:00) ｜オープニング(00:00:51) ｜OP／Podcast Weekend 2026御礼(00:01:47) ｜OP／BABY STEPS(00:16:49) ｜OP／ 獣道10先(00:27:54) ｜本編／デベロッパー/パブリッシャーからメッセージをもらった３作品をなんとか(00:29:37) ｜本編／Point In Time(00:43:33) ｜本編／Witch the Showdown(01:07:03) ｜本編／PAIC: ムーンライダー物語(01:33:02) ｜エンディング //// 番組へのおたより ///////////////番組へのおたより・メッセージは番組ウェブサイト（ https://gamenantoka.com/ ）または gamenantoka@gmail.com へお送りください。 //// 番組YouTubeチャンネル ///////////////ゲームなんとかの今後の活動の幅を広げるため、さらなる番組リスナーさん増加を目指してYouTubeチャンネルを開設しました。ポッドキャストと同じ音源を配信だけではなく、動画ならではの取り組みも挑戦していこうかと思いますので、ぜひともチャンネル登録をお願いいたします。https://www.youtube.com/c/gamenantoka //// その他 ///////////////■ 番組の感想には #ゲームなんとか をお気軽にお使いください！■ X：@gamenantoka
It's the second half of our big ranks reveal! Let's talk about Harris's initial ranks for wide receivers and quarterbacks for the 2026 fantasy football season. Who deserves to go in the first round at these less-scarce positions? How many trustable WR1s are there really, and how should that affect your positional draft strategy? How many QBs are truly worthy of reaching for, and how does that change in a superflex league? Let's go! The 2026 season is really finally officially launched! Guest: Cousin Josh. NOTES: Sponsor - www.TryFum.com code HARRIS for a free gift when you buy a nicotine-free, battery-free solution to quit smoking or vaping Sponsor - www.leesa.com code HARRIS for 30% off (as of May 12) and an extra $50 discount on a great mattress Sponsor - www.BetterHelp.com/harris for 10% off your first month of online therapy where you're matched with a psychotherapist who can help Follow Cousin Josh - www.instagram.com/DetectiveFisch Follow our show on Bluesky - https://bsky.app/profile/harrisfootball.com Follow on Twitter - @HarrisFootball Become a Person of the Book - https://www.amazon.com/Christopher-Harris/e/B007V3P4KK Watch the YouTube channel - www.youtube.com/harrisfootball Harris Football Yacht Club Dictionary - https://harrisfootball.github.io/dictionary.html Join the Harris Football Subreddit - www.reddit.com/r/HarrisFootball Subscribe To the Yacht Club Premium Podcast - https://harrisfootball.supportingcast.fm/ 2026 Wide Receiver Ranks: 1 Ja'Marr Chase CIN 2 Jaxon Smith-Njigba SEA 3 Puka Nacua LAR 4 Amon-Ra St. Brown DET 5 CeeDee Lamb DAL 6 Nico Collins HOU 7 Justin Jefferson MIN 8 Drake London ATL 9 Malik Nabers NYG 10 A.J. Brown PHI? 11 Chris Olave NO 12 DeVonta Smith PHI 13 Tee Higgins CIN 14 Terry McLaurin WAS 15 George Pickens DAL 16 Zay Flowers BAL 17 Davante Adams LAR 18 Jameson Williams DET 19 Tetairoa McMillan CAR 20 Rashee Rice KC 21 D.J. Moore BUF 22 Rome Odunze CHI 23 Emeka Egbuka TB 24 Luther Burden CHI 25 Jaylen Waddle DEN 26 Ladd McConkey LAC 27 Garrett Wilson NYJ 28 Christian Watson GB 29 Alec Pierce IND 30 Courtland Sutton DEN 31 Carnell Tate TEN 32 Parker Washington JAC 33 DK Metcalf PIT 34 Chris Godwin TB 35 Michael Pittman PIT 36 Michael Wilson ARI 37 Jakobi Meyers JAC 38 Mike Evans SF 39 Makai Lemon PHI 40 Ricky Pearsall SF 41 Marvin Harrison ARI 42 Jordyn Tyson NO 43 Brian Thomas JAC 44 Quentin Johnston LAC 45 Jordan Addison MIN 46 Stefon Diggs 47 Josh Downs IND 48 Khalil Shakir BUF 49 Jayden Reed GB 50 Wan'Dale Robinson TEN 51 Jauan Jennings 52 Romeo Doubs NE 53 Jalen Coker CAR 54 Matthew Golden GB 55 Jayden Higgins HOU 56 Brandon Aiyuk 57 Kayshon Boutte NE 58 Jalen McMillan TB 59 Tory Horton SEA 60 Isaac TeSlaa DET 61 KC Concepcion CLE 62 Denzel Boston CLE 63 Troy Franklin DEN 64 Tre Tucker LV 65 Xavier Worthy KC 66 Jerry Jeudy CLE 67 Dontayvion Wicks PHI 68 Rashid Shaheed SEA 69 Tre Harris LAC 70 Omar Cooper NYJ 71 Antonio Williams WAS 72 Chris Bell MIA 73 Travis Hunter JAC 74 Calvin Ridley TEN 75 Jalen Nailor LV 76 Jack Bech LV 77 De'Zhuan Stribling SF 78 Skyler Bell BUF 79 Adonai Mitchell NYJ 80 Jaylin Noel HOU 2026 Quarterback Ranks: 1 Josh Allen BUF 2 Lamar Jackson BAL 3 Joe Burrow CIN 4 Drake Maye NE 5 Matthew Stafford LAR 6 Jayden Daniels WAS 7 Caleb Williams CHI 8 Justin Herbert LAC 9 Jalen Hurts PHI 10 Dak Prescott DAL 11 Trevor Lawrence JAC 12 Jared Goff DET 13 Patrick Mahomes KC 14 Brock Purdy SF 15 Bo Nix DEN 16 Jaxson Dart NYG 17 Jordan Love GB 18 C.J. Stroud HOU 19 Baker Mayfield TB 20 Kyler Murray MIN 21 Daniel Jones IND 22 Tyler Shough NO 23 Sam Darnold SEA 24 Bryce Young CAR 25 Malik Willis MIA 26 Cam Ward TEN 27 Jacoby Brissett ARI 28 Aaron Rodgers PIT 29 Fernando Mendoza LV 30 Geno Smith NYJ 31 Michael Penix ATL 32 Deshaun Watson CLE 33 Tua Tagovailoa ATL 34 Justin Fields KC 35 Kirk Cousins LV 36 Jameis Winston NYG 37 Marcus Mariota WAS 38 Shedeur Sanders CLE 39 Mac Jones SF 40 Joe Flacco CIN 41 J.J. McCarthy MIN 42 Davis Mills HOU 43 Riley Leonard IND 44 Cade Klubnik NYJ 45 Jarrett Stidham DEN 46 Ty Simpson LAR 47 Tanner McKee PHI 48 Carson Beck ARI 49 Carson Wentz MIN 50 Drew Allar PIT
It's a Sunday Funday edition of the After Party! And for this one we got the return of Marcy! She comes on as we reminisce on Jaguars Gentlemen's Club, the most she's made in one night as a dancer and dumps some trauma on the podcast. Follow us on social media @AaronScenesAfterParty
Save your roster with our three-round, post-NFL Draft superflex dynasty rookie mock draft for 2026 fantasy football leagues! Is taking Los Angeles Rams QB Ty Simpson worth ending relationships over? Has Denver Broncos RB Jonah Coleman re-joined the first-round conversation? Plus, can Buffalo Bills WR Skyler Bell live up to his potential in Western New York? Seth, Eric & Steve help managers whether rebuilding or contending on a new episode of the podcast! ⏰ Time Stamps: 00:00:00 Introduction 00:05:28 Front & Center: 2026 Rookie Mock Draft 00:06:12 1.01: Fernando Mendoza (QB – LV) 00:07:15 1.02: Jeremiyah Love (RB – ARI) 00:08:49 1.03: Carnell Tate (WR – TEN) 00:12:22 1.04: Jordyn Tyson (WR – NO) 00:13:33 1.05: Makai Lemon (WR – PHI) 00:15:59 1.06: Jadarian Price (RB – SEA) 00:17:54 1.07: Ty Simpson (QB – LAR) 00:20:02 1.08: Kenyon Sadiq (TE – NYJ) 00:22:10 1.09: KC Concepcion (WR – CLE) 00:24:58 1.10: Eli Stowers (TE – PHI) 00:26:11 1.11: Jonah Coleman (RB – DEN) 00:30:04 1.12: Antonio Williams (WR – WAS) 00:32:27 2.01: Omar Cooper Jr. (WR – NYJ) 00:35:11 2.02: Nicholas Singleton (RB – TEN) 00:37:40 2.03: Denzel Boston (WR – CLE) 00:39:44 2.04: De'Zhaun Stribling (WR – SF) 00:41:10 2.05: Chris Bell: (WR – MIA) 00:42:40 2.06: Carson Beck (QB – ARI) 00:44:54 2.07: Germie Bernard (WR – PIT) 00:46:14 2.08: Elijah Sarratt (WR – BAL) 00:48:50 2.09: Malachi Fields (WR – NYG) 00:51:14 2.10: Chris Brazzell II (WR – CAR) 00:52:29 2.11: Ted Hurst (WR – TAM) 00:55:04 2.12: Emmett Johnson (RB – KC) 00:58:40 IBT Football Family Promo 00:59:57 3.01: Skyler Bell (WR – BUF) 01:04:14 3.02: Kaytron Allen (RB – WAS) 01:05:27 3.03: Ja'Kobi Lane (WR – BAL) 01:07:05 3.04: Zachariah Branch (WR – ATL) 01:08:37 3.05: Bryce Lance (WR – NO) 01:10:00 3.06: Mike Washington (RB – LVR) 01:11:13 3.07: Eli Heidenreich (RB – PIT) 01:12:44 3.08: Taylen Green (QB – CLE) 01:14:51 3.09: Drew Allar (QB – PIT) 01:17:13 3.10: Brenen Thompson (WR – LAC) 01:18:12 3.11: Kaelon Black (RB – SF) 01:20:17 3.12: Adam Randall (RB – BAL) 01:21:37 Plugs + Outro
VOV1 - Đại hội XIV của Đảng đề ra hai mục tiêu chiến lược 100 năm; đồng thời xác lập mục tiêu tăng trưởng GDP bình quân trên 10%/năm cho giai đoạn 2026–2030. Thế nhưng các thế lực thù địch không từ mọi thủ đoạn chống phá, bôi nhọ các mục tiêu phát triển mà Đảng ta đề ra.Đại hội đại biểu toàn quốc lần thứ XIV của Đảng đã xác lập mục tiêu tăng trưởng GDP bình quân trên 10%/năm cho giai đoạn 2026–2030. Đây là mục tiêu đầy khát vọng, hoàn toàn khả thi, tuy nhiên, trên không gian mạng, các thế lực thù địch thường xuyên đưa ra các luận điệu bôi nhọ, xuyên tạc mục tiêu này. Chúng cáo buộc rằng đây chỉ là “bánh vẽ”, "chạy theo thành tích" bất chấp chất lượng tăng trưởng. Qua đó, gieo rắc sự hoài nghi trong xã hội. Chuyên mục “Nhận diện sự thật” hôm nay với sự tham gia của hai vị khách mời: PGS, TS, Thiếu tướng Lê Văn Cương, nguyên Viện trưởng Viện Nghiên cứu Chiến lược Bộ Công an và TS Nguyễn Quốc Việt, chuyên gia về chính sách công Đại học Kinh tế, Đại học Quốc gia Hà Nội sẽ vạch rõ những luận điệu xấu xa này.Các vị khách mời lên sóng trong phòng thu của Đài TNVN
Episode Description:In this special return visit, hosts Infinite and Brick welcome Rise Carter back to the mic. Rise—a familiar voice from Season 1 (Episode 45)—joins us to catch up on what she's been up to since we last spoke. This conversation dives into the evolution of her music, the projects she's currently passionate about, and the key things that have changed since her previous appearance. Off the stage and studio, Rise also shares exciting ventures she's pursuing outside of music, shedding light on the person behind the art. Tune in for candid stories, fresh insights, and a deeper look at Rise Carter's journey from then to now.What you'll hear:A candid update from Rise on current projects and musical directionReflections on changes since her Season 1 appearance (Episode 45)Behind-the-scenes details about life outside musicPersonal anecdotes and inspirations that fuel her work todayConversations between Infinite, Brick, and Rise about growth, resilience, and creative evolutionWho should listen:Fans of Rise Carter curious about her latest endeavorsLongtime listeners of Infinite and Brick's conversationsAnyone interested in the intersection of music and other creative pursuitsRelease date: 5-6-26Length: ~ Just over an hourWhere to listen: Right here or all major platformsWe would LOVE to hear what you think. Please drop a line.Support the show
VOV1 - Đại hội đại biểu lần thứ XIV của Đảng đã xác lập mục tiêu tăng trưởng GDP bình quân trên 10%/năm cho giai đoạn 2026–2030. Đây là mục tiêu đầy khát vọng, hoàn toàn khả thi, tuy nhiên, trên không gian mạng, các thế lực thù địch thường xuyên đưa ra các luận điệu bôi nhọ, xuyên tạc mục tiêu này.Xây dựng đất nước hùng cường, thịnh vượng là khát vọng ngàn đời của dân tộc Việt Nam. Trải qua nhiều thăng trầm trong lịch sử, khát vọng dựng nước đi đôi với giữ nước ngày càng trở nên mãnh liệt hơn và đã được Đại hội đại biểu toàn quốc lần thứ XIV của Đảng Cộng sản Việt Nam (Đại hội XIV) hiện thực hóa thành những mục tiêu chiến lược. Những mục tiêu đó là gì? Đại hội XIV của Đảng đề ra hai mục tiêu chiến lược 100 năm nhằm đưa Việt Nam bước vào kỷ nguyên vươn mình, tập trung vào các dấu mốc: năm 2030 (100 năm thành lập Đảng) trở thành nước đang phát triển có công nghiệp hiện đại, thu nhập trung bình cao; và năm 2045 (100 năm thành lập nước) trở thành nước phát triển, thu nhập cao; đồng thời xác lập mục tiêu tăng trưởng GDP bình quân trên 10%/năm cho giai đoạn 2026–2030. Đây là những cột mốc quan trọng trên chặng đường phát triển mới của dân tộc; là “xương sống” định hình đại cục phát triển chung của đất nước; là “hệ đo lường” đánh giá năng lực lãnh đạo, cầm quyền của Đảng.MC Hằng Nga và hai vị khách mời: PGS, TS, Thiếu tướng Lê Văn Cương, nguyên Viện trưởng Viện Nghiên cứu Chiến lược Bộ Công an và TS Nguyễn Quốc Việt, chuyên gia về chính sách công Đại học Kinh tế, Đại học Quốc gia Hà Nội
You could become a Canadian citizen if you look back far enough into your family tree; Britney was sentenced in her DUI case! Dolly Parton is okay, even though she had to cancel her LV residency for non life threatening medical issues; One Star Reviews and the Five Second Rule! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Lv.208配信です。今回のテーマはドラクエ７リイマジンドについて。界隈では有名なキーファ＝オルゴデミーラ説を今見つめ直す。説を肯定したくも否定したくもあるアンビバレントな気持ちをねっとりめにお届けします
Former Tiger Joey Magnifico Joins the Program to Talk Ball with Gabe! Trip Around the NFL: MIN, LAC, LV, KC, NYJ, CLE, TEN!
LAUDES MARTES DE LA IV SEMANA DE PASCUA(Oración de la mañana) - lV semana del SalterioINVOCACIÓN INICIALV. Señor abre mis labiosR. Y mi boca proclamará tu alabanza. INVITATORIOAnt. Verdaderamente ha resucitado el Señor. Aleluya.SALMODIASalmo 100 - Ant. El que hace la voluntad de mi Padre entrara en el reino de los cielos. Aleluya.Cántico - Ant. Conozcan los pueblos, Señor, tú misericordia con nosotros. Aleluya.Salmo 143 - Ant. El Señor es mi escudo y mi refugio. Aleluya.RESPONSORIO BREVEV. El Señor ha resucitado del sepulcro. Aleluya, Aleluya.R. El Señor ha resucitado del sepulcro. Aleluya, Aleluya.V. El que por nosotros colgó del madero. R. Aleluya, Aleluya.V. Gloria al Padre, y al Hijo, y al Espíritu Santo. R. El Señor ha resucitado del sepulcro. Aleluya, Aleluya.CÁNTICO EVANGÉLICOAnt. Las obras que el Padre me concede realizar, las mismas que hago, testifican que el Padre me ha enviado. Aleluya.Cántico de Zacarías. EL MESÍAS Y SU PRECURSOR Lc 1, 68-79Bendito sea el Señor, Dios de Israel,porque ha visitado y redimido a su pueblo.suscitándonos una fuerza de salvaciónen la casa de David, su siervo,según lo había predicho desde antiguopor boca de sus santos profetas:Es la salvación que nos libra de nuestros enemigosy de la mano de todos los que nos odian;ha realizado así la misericordia que tuvo con nuestros padres,recordando su santa alianzay el juramento que juró a nuestro padre Abraham.Para concedernos que, libres de temor,arrancados de la mano de los enemigos,le sirvamos con santidad y justicia,en su presencia, todos nuestros días.Y a ti, niño, te llamarán Profeta del Altísimo,porque irás delante del Señora preparar sus caminos,anunciando a su pueblo la salvación,el perdón de sus pecados.Por la entrañable misericordia de nuestro Dios,nos visitará el sol que nace de lo alto,para iluminar a los que viven en tinieblay en sombra de muerte,para guiar nuestros pasospor el camino de la paz.Gloria al Padre, y al Hijo, y al Espíritu Santo.Como era en el principio, ahora y siempre, por los siglos de los siglos. Amén.PRECES“Autor de la vida, vivifícanos.”ConclusionV. El Señor nos bendiga, nos guarde de todo mal y nos lleve a la vida eterna.R. Amén.(266)
We have Daniel Schlagwein on the show, who is what Germans call a "Tausendsassa:" He is both a practitioner and researcher of digital nomadism, the editor-in-chief of the Journal of Information Technology, and president of the AIS special interest group on Grounded Theory Methodology. We touch upon all three of these aspects, but at the core we want to know from Daniel whether generative AI tools are automating grounded theory and thereby eliminate what used to be at the heart of a humanistic and constructionist approach to doing research – or are they merely leveling the playing field for qualitative field researchers by giving them computational support matching those tools that quantitative researchers have had for a long time. Daniel argues that it depends on the specific flavor of the grounded theory method you are using to determine whether and how you can leverage generative AI for such research. References Wang, B., Schlagwein, D., Cecez-Kecmanovic, D., & Cahalane, M. C. (2025). 'Emancipation' in Digital Nomadism vs in the Nation‑State: A Comparative Analysis of Idealtypes. Journal of Business Ethics, 198(1), 35–68. Hoffman, P. (1998). The Man Who Loved Only Numbers. Hyperion Books. Garland, A. (1996). The Beach. Viking. Jiwasiddi, A., Schlagwein, D., Cahalane, M. C., Cecez-Kecmanovic, D., Leong, C., & Ractham, P. (2024). Digital Nomadism as a New Part of the Visitor Economy: The Case of the 'Digital Nomad Capital' Chiang Mai, Thailand. Information Systems Journal, 34(5), 1493–1535. Fromm, E. (1941). Escape from Freedom. Farrar & Rinehart. Glaser, B. G., & Strauss, A. L. (1967). The Discovery of Grounded Theory: Strategies for Qualitative Research. Aldine Publishing Company. Glaser, B. G. (1978). Theoretical Sensitivity: Advances in the Methodology of Grounded Theory. Sociology Press. Strauss, A. L., & Corbin, J. (1998). Basics of Qualitative Research: Techniques and Procedures for Developing Grounded Theory (2nd ed.). Sage. Charmaz, K. C. (2014). Constructing Grounded Theory: A Practical Guide through Qualitative Analysis (2nd ed.). Sage. Nelson, L. K. (2020). Computational Grounded Theory: A Methodological Framework. Sociological Methods & Research, 49(1), 3–42. Gopal, R., Li, J., Riemer, K., Sarker, S., Singh, P. V., Susarla, A., Bichler, M., & Thatcher, J. B. (2025). Inventing with Machines: Generative AI and the Evolving Landscape of IS Research. Information Systems Research, 36(4), 1949–1967. Zhou, Y., Yuan, Y., Huang, K., & Hu, X. (2024). Can ChatGPT Perform a Grounded Theory Approach to Do Risk Analysis? An Empirical Study. Journal of Management Information Systems, 41(4), 982–1015. Yue, Y., Liu, D., Lv, Y., Hao, J., & Cui, P. (2025). A Practical Guide and Assessment on Using ChatGPT to Conduct Grounded Theory: Tutorial. Journal of Medical Internet Research, 27, e70122. Wiesche, M., Jurisch, M., Yetton, P., & Krcmar, H. (2019). Grounded Theory Methodology in Information Systems Research. MIS Quarterly, 41(3), 685–701. Sarker, S., Xiao, X., Beaulieu, T., & Lee, A. S. (2018). Learning from First-Generation Qualitative Approaches in the IS Discipline: An Evolutionary View and Some Implications for Authors and Evaluators (PART 1/2). Journal of the Association for Information Systems, 19(8), 752–774. AIS Special Interest Group on Grounded Theory Methodology (SIG GTM): https://aisnet.org/members/member_engagement/groups.aspx?code=SIGGTM. Recker, J., Zeiss, R., & Mueller, M. (2024). iRepair or I Repair? A Dialectical Process Analysis of Control Enactment on the iPhone Repair Aftermarket. MIS Quarterly, 48(1), 321–346.
LAUDES LUNES DE LA IV SEMANA DE PASCUA(Oración de la mañana) - lV semana del SalterioINVOCACIÓN INICIALV. Señor abre mis labiosR. Y mi boca proclamará tu alabanzaINVITATORIOAnt. Verdaderamente ha resucitado el Señor. Aleluya.SALMODIASalmo 89 - Ant. Baje a nosotros la bondad del Señor, Aleluya.Cántico - Ant. Convertiré ante ellos la tiniebla en la luz. Aleluya.Salmo 134 - Ant. El Señor todo lo que quiere lo hace. Aleluya.RESPONSORIO BREVEV. El Señor ha resucitado del sepulcro. Aleluya, Aleluya.R. El Señor ha resucitado del sepulcro. Aleluya, Aleluya.V. El que por nosotros colgó del madero. R. Aleluya, Aleluya.V. Gloria al Padre, y al Hijo, y al Espíritu Santo. R. El Señor ha resucitado del sepulcro. Aleluya, Aleluya.CÁNTICO EVANGÉLICOAnt. Yo soy el buen Pastor, que apaciento a mis ovejas y doy mi vida por ellas. Aleluya.Cántico de Zacarías. EL MESÍAS Y SU PRECURSOR Lc 1, 68-79Bendito sea el Señor, Dios de Israel,porque ha visitado y redimido a su pueblo.suscitándonos una fuerza de salvaciónen la casa de David, su siervo,según lo había predicho desde antiguopor boca de sus santos profetas:Es la salvación que nos libra de nuestros enemigosy de la mano de todos los que nos odian;ha realizado así la misericordia que tuvo con nuestros padres,recordando su santa alianzay el juramento que juró a nuestro padre Abraham.Para concedernos que, libres de temor,arrancados de la mano de los enemigos,le sirvamos con santidad y justicia,en su presencia, todos nuestros días.Y a ti, niño, te llamarán Profeta del Altísimo,porque irás delante del Señora preparar sus caminos,anunciando a su pueblo la salvación,el perdón de sus pecados.Por la entrañable misericordia de nuestro Dios,nos visitará el sol que nace de lo alto,para iluminar a los que viven en tinieblay en sombra de muerte,para guiar nuestros pasospor el camino de la paz.Gloria al Padre, y al Hijo, y al Espíritu Santo.Como era en el principio, ahora y siempre, por los siglos de los siglos. Amén.PRECES“Ilumina, Señor, nuestras mentes.”ConclusionV. El Señor nos bendiga, nos guarde de todo mal y nos lleve a la vida eterna.R. Amén.(264)
We're live on 4/20 from our sponsors Apogee in Sunland Park NM! And on this one we bring on our boy 3am as we catch up with him and he shares some of his most recent projects. Plus he tells us all about his crazy Las Vegas work schedule, doing work for the World Cup and he tells us some of his DJ do's and don'ts! And the OG cohost Marky Mark stops by for a little edible action. Follow us on social media @AaronScenesAfterParty
Game over, man? Not even close.This week on Dads From the Crypt, we're locking and loading for a deep-dive review of Aliens—the explosive sequel that took Alien's slow-burn terror and turned it into an all-out sci-fi horror war film. Joining us is Rachel Shatto from the Zombie Grrlz to break down everything from xenomorph chaos to Ripley's evolution into one of cinema's greatest heroes.Directed by James Cameron and starring Sigourney Weaver in an Oscar-nominated performance, Aliens raises the stakes with unforgettable action, iconic characters, and one of the most intense final acts in horror history.We discuss:Is Aliens better than Alien?Ripley vs. the Alien Queen
Sự chào đón nồng nhiệt dành cho Trịnh Lệ Văn cho thấy hy vọng của Bắc Kinh về một sự ‘thống nhất trong hòa bình.'Xem thêm.
It's a pop up podcast! And on this episode we have our battle of the cohosts! As Gee and Baby M take each other head on on a variety of questions plus they prove whether guys and girls can solely and ONLY be friends. AND the gang tries out some honey packs and give our honest review. Follow us on social media @AaronScenesAfterParty
Why does every fashion brand run a coffee shop? How did a Stussy varsity jacket network from the late 1980s predict the business model of modern fashion? What does used spray paint have to do with why Miu Miu is one of the most effective brands in the world right now?Sol Thompson and Michael Smith open Season 14 of the Pair of Kings Podcast with a level set: the history of integrated fashion—the idea that buying clothes has always really been about buying into a lifestyle, a cult of personality, and an identity. Starting in 2014 at the height of Tumblr's image-first culture and tracing the full arc through Supreme drop culture, the grail sneaker peak, the outfit grid, the crash of sneaker resale, the rise of archive fashion, and the TikTok lifestyle-as-content revolution, they map how men's relationship with fashion fundamentally changed.They cover the Stüssy Tribe as fashion's original brand ambassador model—featuring Hiroshi Fujiwara, Michael Kopelman, and a pre-Supreme James Jebbia—the Supreme x LV collab as the undisputed peak of drop culture, Kith Treats and Cafe Leon Dore as the architects of the fashion third space, and the Miu Miu Literary Club as the most transparent example of what fashion brands are actually selling. We also touch on Demna's debut Gucci collection and his philosophy as a fashion anthropologist, the Hedi Slimane Saint Laurent Hedi boy cult of personality, the runway appearances of looksmaxxing and body dysmorphia, Vivienne Westwood and punk as integrated fashion's original historical anchor, the CBK/JFK aesthetic overtaking downtown New York, and what it means when even finance bros start buying Celine suits on purpose.Michael's fit: Wabash denim from Sugar Cane, Flat Head houndstooth flannel.Sol's fit: a Daft Punk Musique Vol. 1 CD release tee and a North Face layer.We hope you enjoy it as much as we did making it.Lots of love,Sol---Episode Tags: integrated fashion, fashion lifestyle, menswear history 2026, drop culture history, grail sneakers, Stussy Tribe, Supreme x Louis Vuitton collab, archive fashion rise, sneaker resale crash, StockX history, Cafe Leon Dore, Kith Treats, fashion third space, Miu Miu Literary Club, Miu Miu girl, Demna Gvasalia Gucci 2026, Hedi Slimane Saint Laurent, Hedi boy aesthetic, Vivienne Westwood punk, looksmaxxing fashion, CBK JFK New York aesthetic, finance bro style 2026, Patagonia vest, Tumblr fashion era, outfit grid, KOTD, Instagram reels fashion, Hiroshi Fujiwara, James Jebbia, A$AP Rocky fashion, Rick Owens darkwear, archive PDF, menswear podcast 2026, Pair of Kings podcast, fashion podcastSol Thompson and Michael Smith explore the world and subcultures of fashion, interviewing creators, personalities, and industry insiders to highlight the new vanguard of the fashion world. Subscribe for weekly uploads of the podcast, and don't forgot to follow us on our social channels for additional content, and join our discord to access what we've dubbed “the happiest place in fashion”.Message us with Business Inquiries at pairofkingspod@gmail.comSubscribe to get early access to podcasts and videos, and participate in exclusive giveaways for $4 a monthLinks:InstagramTikTokTwitter/XSol's Substack (One Size Fits All)Sol's InstagramMichael's InstagramMichael's TikTok
Learn which three NFL players we’re forgiving when we reveal our top second-chance fantasy football breakouts for the 2026 season! Can Indianapolis Colts WR Josh Downs take a jump up in production? Is Tampa Bay Buccaneers WR Chris Godwin destined to return to stardom? Plus, why is it time to go all the way back in on Las Vegas Raiders RB Ashton Jeanty? Seth, Eric & Steve practice what they preach on a new episode of the podcast! ⏰ Time Stamps: 00:00:00 Introduction 00:03:01 Headline Hijinks: Second-Chance Fantasy Football Breakouts 00:03:20 Josh Downs (WR – IND) | ECR 112 (WR47) 00:09:41 Chris Godwin (WR – TB) | ECR 65 (WR31) 00:15:58 IBT Football Family Promo 00:17:22 Ashton Jeanty (RB – LV) | ECR 20 (RB7) 00:23:53 Outro
Cuộc hội đàm "phá băng" tại Đại Lễ đường Nhân dân giữa bà Trịnh Lệ Văn và ông Tập Cận Bình không chỉ là một sự kiện ngoại giao đơn thuần, mà còn là ván cờ địa chính trị xoay chuyển cục diện eo biển Đài Loan. Trong bối cảnh căng thẳng quân sự leo thang và bóng ma chia rẽ nội bộ bủa vây, "hành trình vì hòa bình" này đang đặt ra dấu hỏi lớn: Liệu đây là khởi đầu của kỷ nguyên đối thoại hay chỉ là nước cờ chiến lược đầy toan tính?
Trịnh Lệ Văn, lãnh đạo Quốc Dân Đảng đối lập tại Đài Loan, đang dẫn đầu một phái đoàn sang thăm Trung Quốc từ ngày 7 đến 12 tháng 4. Đây là chuyến thăm đầu tiên của một chủ tịch KMT trong một thập niên qua, và bà Trịnh dự kiến sẽ có cuộc hội kiến với Chủ tịch Trung Quốc Tập Cận Bình.Xem thêm.
6. Henry Sokolski: Henry Sokolski details the critical reliance of nuclear power plants on external electricity for cooling. He warns about Iranianhackers targeting the US electrical grid and how Russian and Chinesetargeting information enhances the lethality of foreign drone and missile technologies. (6)1954 DESERT INN, LV
We are LIVE for this episode at Sunset Dive! DJ Snack comes on as we talk about good times at EDC plus! We bring on a couple of Sunset bartenders for a sit down as they tell us about the biggest tip they've ever made and some crazy bartending stories! Follow us on social media @AaronScenesAfterParty
Happy National Caramel Day!Ladies and gentlemen, what a weekend for sports! Episode 384 is a rough one if you anticipated good basketball in the Final 4, with UConn and Michigan putting a choke hold on their games. Outside of the Final 4 we had Geno and Dawn dust up, Super Mario Bros Galaxy review, Kirk Cousins to LV, more baseball food, and Frozen Four is next week! PLUS, a special look ahead to Masters week with some fun tid bits!As for golf, The PGA took place this weekend at TPC San Antonio Golf Course in Texas where JJ Spaun out of nowhere (RKO), came back to win the Valero Open! The G.U.Y.S were MIA this weekend for DraftKings DFS, because we have not yet transitioned our brains out of football/olympics/spring break mode! We will still throw out some Hang The Banners, Shambles Meter, and talk Other Relevant Sports News. We've got it all, let's laugh!Look alive folks!Follow us on:HOF Bets: https://hof-bets.app.link/millygoats (Promo Code: MILLYGOATS)Twitter - https://www.twitter.com/MillyGoatsInstagram - https://www.instagram.com/TheMillyGoatsYouTube - https://www.youtube.com/@TheMillyGoatsTwitch - https://www.twitch.tv/TheMillyGoatsPodcastTikTok - https://www.tiktok.com/@TheMillyGoatsApple Pod - https://rb.gy/0meu1Spotify Pod - https://t.ly/ZUfObWeb - https://themillygoats.godaddysites.com/
We discuss the diagnosis and treatment of one of EM's paradoxes: High-Output Heart Failure. Hosts: Nicolas Gonzalez, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/HOHF.mp3 Download Leave a Comment Tags: Cardiology Show Notes Core EM Modular CME Course Maximize your commute with the new Core EM Modular CME Course, featuring the most essential content distilled from our top-rated podcast episodes. This course offers 12 audio-based modules packed with pearls! Information and link below. Course Highlights: Credit: 12.5 AMA PRA Category 1 Credits™ Curriculum: Comprehensive coverage of Core Emergency Medicine, with 12 modules spanning from Critical Care to Pediatrics. Cost: Free for NYU Learners $250 for Non-NYU Learners Click Here to Register and Begin Module 1 1. Core Definition & Hemodynamic Profile Clinical Paradox: Congestive symptoms (pulmonary edema, JVD, peripheral edema) in the setting of a hyperdynamic, supranormal cardiac function. Hemodynamic Criteria: Cardiac Index (CI): >4.0 L/min/m2. Cardiac Output (CO): >8 L/min. Systemic Vascular Resistance (SVR): Pathologically low (vasodilated or shunted state). The “Warm” Phenotype: Unlike standard HFrEF/HFpEF (often “Cold and Wet”), HOHF presents as “Warm and Wet” due to low SVR and bounding pulses. 2. Pathophysiology: The Hemodynamic Paradox Primary Insult: Decreased SVR (either via peripheral vasodilation or arteriovenous shunting). Effective Arterial Blood Volume: Paradoxically low despite high total CO. Neurohormonal Cascade: Activation of Renin-Angiotensin-Aldosterone System (RAAS). Increased Sympathetic Nervous System tone. Increased Antidiuretic Hormone (ADH) secretion. Resultant State: Avid renal salt and water retention leading to massive plasma volume expansion. Cardiac Response: Chronic volume overload → eccentric remodeling → chamber dilation → eventual secondary myocardial failure/dilated cardiomyopathy. 3. Differential Diagnosis: Etiological “Buckets” Category A: Increased Metabolic Demand (Systemic) Hyperthyroidism/Thyrotoxicosis: Direct T3 effects: increased chronotropy/inotropy. Indirect effects: metabolic byproduct accumulation causing peripheral vasodilation. Myeloproliferative Disorders: High cell turnover and increased oxygen consumption drive compensatory CO increase. Sepsis (Hyperdynamic Phase): Cytokine-mediated global vasodilation. Note: Often transient; may transition to sepsis-induced myocardial depression. Category B: Peripheral Vascular Effects (Shunting/Vasodilation) Arteriovenous Fistulas (AVF) / Malformations (AVM): Most Common Cause: Iatrogenic AVF for Hemodialysis (ESRD population). Bypasses high-resistance capillary beds, dumping arterial blood directly into venous circulation. Chronic Liver Disease (Cirrhosis): Formation of “spider angiomata” and internal AV shunts. Impaired clearance of endogenous vasodilators (e.g., Nitric Oxide). Thiamine Deficiency (Wet Beriberi): Accumulation of pyruvate/lactate → systemic vasodilation. Histopathology: Vacuolation, myofiber hypertrophy, and interstitial edema. Chronic Lung Disease: Hypoxia/Hypercapnia-driven systemic vasodilation. Concomitant pulmonary HTN (RV remodeling) but preserved/high LV output. Others: Paget's disease of bone (extensive micro-shunting), Carcinoid syndrome, Mitochondrial diseases, Acromegaly, Erythroderma. 4. Special Focus: Hemodialysis Access-Induced HOHF Physiologic Phases of AVF Creation: Acute Phase: Immediate ↓ SVR. ↑ Stroke volume and Heart Rate (SNS-mediated). Endothelial shear stress → Nitric Oxide release → further arterial dilation. Subacute Phase (Days to 2 Weeks): RAAS-driven volume expansion. ↑ Right Atrial, Pulmonary Artery, and LV End-Diastolic Pressures (LVEDP). Natriuretic peptide surge (BNP/ANP) peaks around Day 10. Chronic Phase (Weeks to Months): Adaptive hypertrophy. Decompensation occurs when dilation exceeds contractility limits. 5. Point-of-Care Physical Exam & Maneuvers Nicoladoni-Branham Sign (Pathognomonic for Shunt-driven HOHF): Maneuver: Manually compress the AVF (or inflate cuff to >50 mmHg above SBP) for 30 seconds. Positive Result: Reflexive bradycardia or a transient rise in systemic BP. Significance: Confirms the shunt is a major contributor to the cardiac workload. Peripheral Pulse Assessment: Water Hammer Pulses: Rapid upstroke and collapse. Quincke's Pulse: Visible capillary pulsations in the nail beds. Traube's Sign: “Pistol-shot” sounds auscultated over the femoral arteries. Volume Status: Rales, S3 gallop, peripheral edema (standard HF signs). 6. Diagnostic Workup (Technical Targets) POCUS / Echocardiography: Left Ventricle: Hyperdynamic function; EF typically >60%. Left Atrium: Significant dilation (Left Atrial Volume Index >34 mL/m2; Case study noted 72 mL/m2). IVC: Plethoric with minimal respiratory variation. Doppler: High flow velocities across the AV access if applicable. Laboratory Evaluation: BNP/NT-proBNP: Often markedly elevated (e.g., >70,000 in severe cases), though mean values in literature hover around 700–800 pg/mL. Hematology: CBC to evaluate for severe anemia (trigger for HOHF if Hgb7–8 g/dL to reduce demand. Beriberi: High-dose IV Thiamine (100–500 mg). Thyrotoxicosis: Beta-blockers (Propranolol) + Antithyroid meds (PTU/Methimazole). Phase 3: Surgical/Interventional Salvage (Refractory AVF Cases) Closure of Accessory Sites: If multiple fistulas exist, close the non-dominant/unused sites. Flow Reduction (Banding): Surgical narrowing of the fistula to target flow
CardioNerds (Dr. Hamza Patel, Dr. Jenna Skowronski, and Dr. Apoorva Gangavelli) discuss advanced heart failure and LVAD management with Dr. Mark Belkin, Advanced Heart Failure & Transplant Cardiologist, and Dr. Chris Salerno, Cardiothoracic Surgeon. They explore the nuances of right ventricular (RV) physiology, perioperative hemodynamic optimization, long-term complications, sensitization and transplant considerations, and the evolving role of GDMT in LVAD patients. This episode highlights the delicate interplay between surgical and medical management in achieving optimal outcomes for patients living with durable mechanical circulatory support.Audio editing by CardioNerds Academy intern, student doctor, Pace Wetstein. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Heart Success Series PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls “The right ventricle sets the stage.” — LVAD success hinges on RV performance; a struggling RV can turn a perfect LVAD surgery into a perfect storm. “Watch the ratios.” — A PAPi < 2 and RA:PCWP >0.6 signal high risk for RV failure post-implant; trends and response to optimization matter more than static numbers. “From hemocompatibility to hemodynamics.” — The LVAD field has moved from fighting pump thrombosis to mastering long-term RV failure and aortic insufficiency. “Not all antibodies are created equal.” — LVAD-related sensitization often resolves post-transplant, reminding clinicians to interpret PRA trends in context. “Recovery is possible.” — The RESTAGE-HF trial and emerging SGLT2 data hint at a new era: not just sustaining life with LVADs but restoring native heart function. Notes Notes drafted by Dr. Hamza Patel. 1. Hemodynamic & Vasoactive Management of the RV Use norepinephrine and vasopressin for pressor support; consider dobutamine as inotrope of choice. Consider avoiding early milrinone due to hypotension and reduced coronary perfusion. Use inhaled NO or epoprostenol selectively; institutional variation depends on cost and supply. Key hemodynamic markers: PAPi = (PA systolic – PA diastolic) / RA pressure. PAPi < 2 → increased RV failure risk. RA:PCWP ratio ≈ 0.6 normal; ≈ 1 → severe RV dysfunction. RV reserve—the ability to improve these indices with optimization—is a stronger predictor of outcomes than baseline numbers alone. NOTE: there is no robust data to guide vasoactive medical decision-making and there is substantial institutional variability in practive. 2. Long-Term LVAD Complications MOMENTUM 3 trial: HeartMate 3 reduced pump thrombosis (10 → 1 %), stroke (14 → 5%), and GI bleed (77 → 43 %). Persistent issues: driveline infections, RV failure, and aortic insufficiency. Driveline care: silver sulfadiazine (Silvadene) cream linked to lower infection rates (Cowher & Kenmore 2025). Field now focuses on hemodynamic-related adverse events—the next frontier in LVAD outcomes. Innovation ahead: smaller drivelines and fully implantable LVADs to eliminate infection risk. 3. Sensitization and Transplant Candidacy LVADs may induce de novo HLA antibodies, complicating transplant matching. These antibodies tend to be transient and less cytotoxic, often resolving post-transplant. Sensitization degree varies by device and patient; management strategies are center-dependent. The field is redefining which antibodies are truly LVAD-induced versus incidental. 4. GDMT & Myocardial Recovery GDMT data in LVAD patients limited—excluded from major HFrEF trials. RESTAGE-HF: aggressive GDMT post-LVAD yielded 52% explant rate within 18 months. SGLT2 inhibitors: emerging evidence of reverse remodeling and reduced LV size (Belkin et al., THT 2025). GDMT promotes recovery but requires cautious titration to avoid hypotension and RV strain. 5. Future of LVAD Therapy The fully implantable LVAD remains the goal—wireless energy, no driveline, and fewer infections. Short-term focus: device miniaturization, improved energy efficiency, and better hemocompatibility. HeartMate 3 remains gold standard until next-generation systems mature. References Mehra MR et al. NEJM 2018 — MOMENTUM 3 Final Report. Takeda K et al. JHLT 2020 — Predictors of RV Failure After LVAD. Imamura T et al. Circ Heart Fail 2017 — Hemodynamics and RV Adaptation Post-LVAD. RESTAGE-HF Trial, JHLT 2019. Cowher J, Kenmore C et al. 2025 — Driveline Care & Infection Outcomes. Belkin M et al. THT 2025 — SGLT2 Inhibition and Reverse Remodeling Post-LVAD.
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