Cleveland Clinic Cancer Advances

The Cancer Advances podcast is joined by Justin Lathia, PhD, Melvin H. Burkhardt Endowed Chair for Neuro-Oncology Research, Scientific Director of the Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, and the Vice Chair of the Department of Cardiovascular and Metabolic Sciences at Cleveland Clinic's Lerner Research Institute to talk about his study on mitochondria transfer for glioblastoma. Listen as Dr. Lathia shares the complexity of glioblastomas, the challenges in treating it, and the potential of mitochondria transfer as a communication process.

Mr. Stewart Kohl, co-CEO of the Riverside Company, a member of the board of directors at Cleveland Clinic, and founder of VeloSano joins the Cancer Advances podcast to celebrate 10 years of Cleveland Clinic's cancer research fundraising initiative, VeloSano. Listen as Mr. Kohl talks about the journey of VeloSano's 10-year impact on advancing cancer research.

In this episode of Cancer Advances, host Dale Shepard, MD, PhD, talks with Tatiana Byzova, PhD, a staff member in the neurosciences program, about the significance of thrombosis in cancer patients along with current therapy options. Listen as they discuss the challenges of balancing anticoagulant therapy, and Dr. Byzova's research on tumor-platelet interactions and the role of vesicles in thrombus formation. This thought-provoking discussion sheds light on potential treatment options and the importance of understanding the intricate relationship between cancer and thrombosis.

Gary Schwartz, MD, Director of the Case Comprehensive Cancer Center, and a medical oncologist who specializes in sarcoma joins the Cancer Advances podcast to discuss his goal of improving cancer care not just in Cleveland, but beyond. Listen as he talks about his vision for seamless integration of science and clinical practice and fostering rapid translation from bench to bedside and more.

In this episode of the Cancer Advances podcast, Dale Shepard, MD, PhD is joined by Shlomo Koyfman, MD, Director of Head and Neck and Skin Radiation at Cleveland Clinic to discuss the use of stereotactic body radiation therapy (SBRT) for head and neck cancer treatment. Dr. Koyfman shares insights from his experience highlighting the role of SBRT in re-irradiation cases as a primary therapy option. This informative conversation sheds light on the innovative techniques and advancements in radiation oncology that are improving outcomes for patients with head and neck cancer.

Zachary D. Burke, MD, an orthopedic oncologist specializing in pediatric sarcomas, joins the Cancer Advances Podcast to talk about limb sparing surgical techniques for pediatric sarcoma. Listen as Dr. Burke explains the unique challenges posed by pediatric cases, the advancements being made in the field, and research efforts aimed at improving sarcoma treatments.

Arun D. Singh, MD, Director of Ophthalmic Oncology at Cleveland Clinic Cole Eye Institute, joins the Cancer Advances podcast to discuss metastases to the eye. Listen as Dr. Singh talks about the common types of cancer that metastasize to the eye, symptoms, treatment options, and the importance of looking out for metastases in patients.

Adriana Alveraz, MD, regional oncologist and palliative medicine physician, joins the Cancer Advances Podcast to talk about cancer-related anorexia and cachexia syndrome. Listen as Dr. Alveraz explains the challenges in diagnosing this syndrome, what physicians should pay attention to, as well as the importance of palliative care with cancer treatment.

Joseph Scharpf, MD, FACS, Director of Head and Neck Endocrine Surgery at the Cleveland Clinic Head and Neck Institute, and Emrullah Yilmaz, MD, PhD, an oncologist at Cleveland Clinic Taussig Cancer Institute, specializing in head and neck cancers, join the Cancer Advances podcast to discuss their study that provides insights to treatment strategies and tumor characteristics of anaplastic thyroid cancer. Listen as Dr. Scharpf and Dr. Yilmaz discuss patients with BRAF mutations and Cleveland Clinic's collaborative approach for thyroid cancer care.

Lukas Nystrom, MD, an orthopedic surgeon at Cleveland Clinic specializing in musculoskeletal oncology, joins the Cancer Advances podcast to talk about the management of soft tissue sarcoma in adults. Listen as Dr. Nystrom talks about the misconceptions and the multidisciplinary care that is needed to treat this rare cancer.

Jack Khouri, MD, hematologist oncologist at Cleveland Clinic Cancer Center, who specializes in rare plasma cell disorders joins the Cancer Advances podcast to discuss ide-CEL CAR T-cell therapy and its effectiveness in multiple myeloma patients. Listen as Dr. Khouri talks about the KarMMA trial and his retrospective study.

Sandra Mazzoni, DO, a hematologist at Cleveland Clinic Taussig Cancer Institute joins the Cancer Advances podcast to talk about monoclonal gammopathy of undetermined significance, known as MGUS. Listen as Dr. Mazzoni talks about this abnormal protein and explains when we can still effectively treat patients before it hits all the criteria for becoming multiple myeloma.

Radiation Oncologist, Physician Scientist, and Founding Director of the Center for Hyperthermia at Cleveland Clinic, Jennifer Yu, MD, PhD, joins the Cancer Advances podcast to discuss hyperthermia therapy, which uses heat to destroy cancer cells and shrink tumors. Listen as Dr. Yu explains how this therapy works; and how it helps radiation and chemotherapy treatments become more effective for patients.

The Cancer Advances podcast is joined by Abhay Singh, MD, MPH, a physician with the Department of Hematology and Medical Oncology at Cleveland Clinic to talk about his study, which aimed to identify risk factors for secondary malignancy in breast cancer survivors. This study was presented at the American Society of Hematology (ASH) 2022 annual meeting. Listen as Dr. Singh explains how he explored the different risk factors, such as G-CSF exposure, how the CHIP Clinic might be able to monitor patients, and the long-term goal to figure out which therapies patients should try to avoid.

Alex A. Adjei, MD, PhD, Chair of Cleveland Clinic Taussig Cancer Institute, joins the Cancer Advances podcast to discuss the new Novel Therapeutics Clinic. Listen as Dr. Adjei shares the importance of novel cancer therapetuics, how the clinic is structured, and his hopes of having multiple treatment options for every cancer.

Arun D. Singh, MD, Director of Ophthalmic Oncology at Cleveland Clinic Cole Eye Institute, and Stacey Zahler, DO, a pediatric hematologist-oncologist at Cleveland Clinic Children's join the Cancer Advances podcast to discuss retinoblastoma. Listen as they discuss this unique children's eye cancer, the treatment options available, and the genetic counseling we have at Cleveland Clinic.

Emrullah Yilmaz, MD, PhD, an oncologist at Cleveland Clinic Taussig Cancer Institute specializing in head and neck cancers, joins the Cancer Advances podcast to discuss new ASCO guidelines for recurrent and metastatic head and neck cancers. Listen as Dr. Yilmaz explains how the guidelines focus on biomarkers, tumor mutation burdens, and how they will impact patient care.

Aaron Gerds, MD, MS, a hematologist in Cleveland Clinic Cancer Center's Leukemia and Myeloid Disorders Program and Deputy Director for Clinical Research at the Taussig Cancer Institute joins the Cancer Advances podcast to talk about the MOMENTUM trial that was presented at the American Society of Hematology (ASH) 2022 annual meeting. Listen as Dr. Gerds discusses myelofibrosis, the differences between the trial results from 24 to 48 weeks, and the exciting new approaches that are coming to the field.

Hermann Kessler, MD, PhD, a senior colorectal surgeon in the Department of Colorectal Surgery, joins the Cancer Advances podcast to talk about the benefits of a complete mesocolic excision (CME) for patients with colon cancer. Listen as Dr. Kessler talks about improving survival and local recurrence rates, the importance of screening programs, and incorporating different modalities into surgery.

The Cancer Advances podcast is joined by Kate Eshleman, PsyD, a pediatric psychologist in the Center for Pediatric Behavioral Health at Cleveland Clinic Children's to talk about the mental health of children and teenagers with cancer. Listen as Dr. Eshleman discusses the Cleveland Clinic Children's survivorship program, what medical professionals should watch out for, and how to assist patient families.

Chair of the Department of Gastroenterology, Hepatology, and Nutrition, Michelle Kang Kim, MD, PhD, joins the Cancer Advances podcast to discuss neuroendocrine tumors. Listen as Dr. Kim talks about creating a database of biomarker studies, the use of DOTATATE PET CT imaging, and the collaborative, multi-disciplinary approach taken at Cleveland Clinic to treat neuroendocrine tumors.

Christopher Weight, MD, Center Director of Urologic Oncology at Cleveland Clinic joins the Cancer Advances podcast to discuss using artificial intelligence to diagnose kidney cancer. Listen as Dr. Weight explains the progress we have made with imaging-generated software and a fully automated equivalent nephrometry score.

Breast Medical Oncologist at Cleveland Clinic Taussig Cancer Institute, Megan Kruse, MD, joins the Cancer Advances podcast to discuss the differences in the clinical management of invasive lobular breast cancer (ILC) and invasive ductal breast cancer (IDC). Listen as Dr. Kruse discusses the challenges of diagnosing, re-evaluating treatment options, and using genomic data to see different trends for lobular and ductal breast cancer.

Ali Aminian, MD, Director of Cleveland Clinic's Bariatric and Metabolic Institute, joins the Cancer Advances podcast to talk about his study on how bariatric surgery can significantly lower a patient's risk of developing obesity-related cancers. Listen as Dr. Aminian explains how the study saw that with significant weight loss, the risk was reversible across race, sex, and age of the patients.

Director of the Center for Immunotherapy and Precision Immuno-Oncology at Cleveland Clinic, Timothy Chan, MD, PhD, joins the Cancer Advances podcast to discuss the Radiation Oncology-Biology Integration Network (ROBIN). Listen as Dr. Chan talks about this new network of centers, the concentration on multi-modality therapies, and the trials that were funded as part of the center.

Jacob Scott, MD, DPhil, radiation oncologist, associate professor, and staff physician-scientist at Cleveland Clinic, joins the Cancer Advances podcast to talk about the research he presented at the American Society of Radiation Oncology (ASTRO) 2022 Annual Meeting. Listen as Dr. Scott discusses preliminary results from a recent Cleveland Clinic study about using GARD to predict overall survival in patients with HPV positive oropharyngeal squamous cell carcinoma treated with radiotherapy.

Stopping hormone therapy treatment to attempt pregnancy may be an option for hormone-receptor-positive breast cancer patients. Halle Moore, MD, Director of Breast Medical Oncology and Co-Director of the Comprehensive Breast Cancer Program joins the Cancer Advances podcast to discuss her research and encouraging findings of the POSITIVE trial that was presented at the San Antonio Breast Cancer Symposium (SABCS) 2022 annual meeting.

The Director of the Blood and Marrow Transplant Program, Craig Sauter, MD, joins the Cancer Advances podcast to discuss optimizing treatments with CAR T-cell and stem cell transplants. Listen as Dr. Sauter talks about his goals to continue expanding the cellular therapy research team and to improve outcomes for transplant patients.

Sharon Sutherland, MD, Director of the Center for Prevention of Cervical Cancer joins the Cancer Advances podcast to talk about the new center created to help prevent cervical cancer. Listen as Dr. Sutherland highlights the goals of the center, and the collaboration with pathology, primary care physicians, and gynecologic oncologists.

Stacey Zahler, DO, a pediatric hematologist-oncologist at Cleveland Clinic Children's, joins the Cancer Advances podcast to talk about the advances in neuroblastoma care for pediatric patients. Listen as Dr. Zahler talks about current treatment options, creating a metaiodobenzylguanidine (MIBG) therapy center at Cleveland Clinic, and studying difluoromethylornithine (DFMO) against cancer cells.

The emotional, psychological, and mental challenges of living with cancer are significant. In this Cancer Advances Podcast, Kaleena Chilcote, MD, Director of Psycho-Oncology at Taussig Cancer Institute talks about mental healthcare in patients who have cancer. Listen as Dr. Chilcote talks about cancer patients' mental health struggles from the beginning of their journey through survivorship and highlights how oncologists can collaborate with psychiatrists to help cancer patients with their quality of life.

Alex A. Adjei, MD, PhD, the new Chair of Cleveland Clinic Taussig Cancer Institute, joins the Cancer Advances podcast to share his vision for Cleveland Clinic Cancer Center. Listen as Dr. Adjei shares his background, goals, and his vision to integrate clinical trials as first line therapy in patient care.

Surgical Director of the Cleveland Clinic Thyroid Center, Joyce Shin, MD, joins the Cancer Advances podcast to provide surgical insights on thyroid cancer. Listen as Dr. Shin discusses the benefits of multidisciplinary care, molecular profiling, and using a fine needle aspiration for thyroid nodules.

R. Matthew Walsh, MD, Department Chair of General Surgery at Cleveland Clinic, joins the Cancer Advances podcast to talk about surgical options for pancreatic cancer. Listen as Dr. Walsh discusses the Whipple procedure, minimally invasive approaches, robotics improvements and pre-habilitation.

Christopher Wee, MD, a medical oncologist from the Genitourinary Medical Oncology Program at Taussig Cancer Institute joins the Cancer Advances podcast to talk about therapies for metastatic prostate cancer. Listen as Dr. Wee discusses Lutetium-PSMA and the clinical trials that showed patients had better response rates and fewer toxicities when they got lutetium on top of their care.

Cleveland Clinic Akron General oncologic surgeon, Anthony Visioni, MD, joins the Cancer Advances podcast to discuss minimally invasive esophagectomies. Listen as Dr. Visioni talks about esophageal cancers and highlights how the team selects the appropriate surgical approach for these patients.

Christopher Weight, MD, Center Director of Urologic Oncology at Cleveland Clinic joins the Cancer Advances podcast to discuss robot assisted retroperitoneal lymph node dissection (RPLND) for the treatment of testicular cancer. Listen as Dr. Weight explains how this robotic surgery allows shorter hospital stays, quicker recovery time, and a lower rate of chylous ascites.

Shilpa Gupta, MD, director of genitourinary medical oncology at Taussig Cancer Institute and co-leader of the genitourinary oncology program at Cleveland Clinic Cancer Center joins the Cancer Advances podcast to discuss her research that was presented at the American Society of Clinical Oncology (ASCO) 2022 annual meeting. Listen as Dr. Gupta gives us insights into the MAIN-CAV trial and platinum-ineligibility in metastatic urothelial cancer.

Medical Director of the Breast Center at Cleveland Clinic Fairview Hospital, Stephanie Valente, DO, joins the Cancer Advances podcast to discuss the Young Women's Clinic. Listen as Dr. Valente discusses the program, survivorship, and the factors physicians address for younger breast cancer patients.

Chirag Shah, MD, co-director of Breast Radiation and Clinical Research in the Department of Radiation Oncology at Cleveland Clinic, joins the Cancer Advances podcast to discuss breast cancer recurrence. Listen as Dr. Shah discusses his research that was presented at the American Society of Clinical Oncology (ASCO) 2022 annual meeting to help patients that are at risk of recurrence.

Director of the Center of Advanced Robotic and Image-Guided Surgery at Cleveland Clinic's Glickman Urological & Kidney Institute, Jihad Kaouk, MD joins the Cancer Advances podcast to discuss single-port transvesical robot assisted radical prostatectomy. Listen as Dr. Kaouk explains advancements that have been made to prostatectomies and how we are continuing to innovate.

Michael Kattan, PhD, Chair of the Department of Quantitative Health Sciences at Cleveland Clinic, and Rahul Tendulkar, MD, radiation oncologist at Cleveland Clinic Cancer Center join the Cancer Advances podcast to discuss nomograms, a calculation tool designed to allow clinicians to evaluate the collective risk of multiple factors at once. Listen as they discuss the creation of nomograms and how they can be helpful to evaluate treatment options for cancer patients.

Seth Rotz, MD, pediatric hematologist-oncologist and Director of the Childhood Cancer Survivorship Program at Cleveland Clinic Children's, joins the Cancer Advances podcast to talk about CAR T-cell therapies and immunotherapy in pediatric patients. Listen as Dr. Rotz explains the long-term survivorship factors to consider when using these therapies and the exciting studies that are being developed for this type of treatment.

Rahul Tendulkar, MD, radiation oncologist at Cleveland Clinic Cancer Center, joins the Cancer Advances podcast to talk about the PSMA PET scan for patients with prostate cancer. Listen as Dr. Tendulkar explains the benefits and how the scan is changing the way we think about and treat prostate cancer.

Petar Bajic, MD, a urologist in the Center for Men's Health at Cleveland Clinic's Glickman Urological and Kidney Institute, joins the Cancer Advances podcast to discuss Prostate Cancer Survivorship. Listen as Dr. Bajic discusses the difficulties patients face following prostate cancer treatment and the options available to help with urinary and sexual-health issues. He also discusses the importance of a multidisciplinary collaboration between oncologists, general practitioners, and mental health specialists.

J. Joseph Melenhorst, PhD, Director of the Cell Therapy and Immuno-Engineering program and Vice Chair of the Center for Immunotherapy and Precision Immuno-Oncology, joins the Cancer Advances podcast to talk about the future of CAR T-Cell Therapy. Listen as Dr. Melenhorst discusses the progress being made, barriers to overcome, and and how we can improve cellular therapy to treat even more types of cancer.

Nicole Peters, Executive Director of VeloSano in the Cleveland Clinic Philanthropy Institute, joins the Cancer Advances podcast to talk about VeloSano, a year-round fundraising initiative that supports lifesaving cancer research at Cleveland Clinic. Listen as Nicole discusses how VeloSano was started, our flagship Bike to Cure weekend, and highlights of how 100% of the funds go toward advancing cancer research.

Cleveland Clinic hematology oncologist, Allison Winter, MD, joins the Cancer Advances podcast to discuss the early alert process for aggressive lymphoma. Listen as Dr. Winter covers the importance of time to treat for this disease and what Cleveland Clinic is doing to help see patients sooner.

Director of the Lung Cancer Medical Oncology Program at Cleveland Clinic Taussig Cancer Institute, Nathan A. Pennell, MD, PhD joins the Cancer Advances podcast to discuss the KRYSTAL-1 trial, a new treatment option for patients with advanced non-small-cell lung cancer with KRASG12C mutation. Listen as Dr. Pennell explains the trial and findings that were presented at the American Society of Clinical Oncology (ASCO) 2022 annual meeting.

Julie Nowicki PT, DPT, a physical therapist at Cleveland Clinic's Children's, joins the 100th episode of the Cancer Advances podcast to talk about the Pediatric Hematology/Oncology Mobility Program. Listen as Julie discusses the program and the benefit of physical therapy for children undergoing cancer treatments.

Michael Fritz, MD, Section Head of Facial Plastic and Microvascular Surgery in Cleveland Clinic's Head & Neck Institute, joins the Cancer Advances podcast to discuss anterolateral thigh fascia lata rescue flap for osteoradionecrosis. Listen as Dr. Fritz highlights how the operation allows patients to get back to their everyday lives sooner.