Podcasts about Kessler

Dr. Brett Kessler overcame adversity to build an amazing dental career en route to becoming President of the American Dental Association. He shares personal stories, the latest advancements in dentistry, the biggest challenges facing dentists, dental lab solutions, and so much more. Ladies & Gentlemen, you're listening to "Confessions From A Dental Lab" and we're happy you're here. Subscribe today and tell a friend so we can all get 1% better :)Connect with Dr. Kessler on instagram at @bikodds and email him at kesslerb@ada.orgFollow KJ & NuArt on Instagram at @lifeatnuartdental, you can also reach us via email: kj@nuartdental.comLearn more about the lab and request information via our website: https://www.nuartdental.com/new-dentist-contact-form/

Join Fara Williams as she sits down with former FIFA World Player of the Year and UEFA Women's Football Managing Director, Nadine Kessler. They discuss Nadine's incredible career, Wolfsburg's treble win, the groundbreaking UEFA Women's Football Strategy, and get the inside scoop on Women's EURO 2025! Hosted on Acast. See acast.com/privacy for more information.

Programa de Radio No.339, Podcast No.488Transmitido el 16 de abril de 2025 por Radio y TV. Querétaro 100.3 FMContinuamos con nuestros programas dedicados a reseñar las republicaciones para la consola Nintendo Switch de la marca KOEI Software, anteriormente escuchamos la música de dos partes de la saga de Nobunaga's Ambition y en esta ocasión escucharemos la música de la segunda franquicia más longeva de esta desarrolladora, Sangokushi o conocida en nuestro continente como la novela histórica del Romance de los Tres Reinos.Además no se pierdan de la entrevista que tuvimos con los Maestros, Sandra Kessler, Directora Fundadora de la Banda Sinfónica Juvenil Santiago de Querétaro y Trinidad Botello quienes estan preparando los arreglos para el próximo concierto gratuito de Música de Videojuegos que presentará el próximo 30 de abril de 2025 en el Teatro de la Ciudad de Santiago de Querétaro, sin duda un evento que no se pueden perder.

Watch every episode ad-free & uncensored on Patreon: https://patreon.com/dannyjones Eric Czuleger is a National Security student at the RAND Corporation who is focused on using emerging technology to solve persistent challenges in emerging economies, conflict zones, and thriving ecosystems alike. Eric has lived and worked in over 45 countries as an aid volunteer, journalist, and tech storyteller. SPONSORS https://AmericanFinancing.net/Jones - Disclaimer NMLS 182334 nmlsconsumeraccess.org http://morning.ver.so/danny - Use code DANNY for 15% off your first order. https://huel.com/danny - Use code DANNY for 15% off your first order + a free gift. https://www.magicmind.com/dannyjones - Use this link for 50% off a subscription. https://whiterabbitenergy.com/?ref=DJP - Use code DJP for 20% off. GUEST LINKS https://x.com/eczuleger Eric's book: https://amzn.to/3ppXZ6b Eric's newsletter: https://t.co/RQgtbd89rJ FOLLOW DANNY JONES https://www.instagram.com/dannyjones https://twitter.com/jonesdanny OUTLINE 00:00 - Everyone should start their own country 11:30 - America's biggest geopolitical vulnerability 13:26 - 5th generation warfare 25:00 - Operation Doppelganger 33:36 - Russia's psychological warfare on Americans 39:28 - LLMs and social media psych warfare 47:30 - Why is Israel blamed for JFK assassination 53:12 - The rational actor model 58:03 - Napoleon's p**is problem 01:11:09 - Christianity is infiltrating Silicon Valley 01:26:37 - The moon landing 01:42:25 - Government transparency 01:52:29 - Kessler syndrome 01:56:29 - Spreadsheet warfare 02:07:37 - Russia manipulating the information space 02:15:28 - Risk of crowd control weapons 02:22:47 - China's police stations in America 02:35:00 - USAID 02:53:55 - Working at RAND corporation 02:58:56 - America's information defense strategy 03:04:19 - Truth decay Learn more about your ad choices. Visit podcastchoices.com/adchoices

Utah Jazz vs. Minnesota Timberwolves NBA Pick Prediction by Tony T. Jazz at Timberwolves Injuries Collins, Kessler and Markkanen are doubtful for Utah. Martin, Harkless and Collier are questionable. Ingles is questionable for Minnesota. Recent Box Score Key Stats Jazz at Timberwolves 3:30PM ET—Utah fell to 17-64 following their 145-111 home defeat to Oklahoma City. The Jazz shot 38% with 27% from three. Svi Mykhailiuk got 27 points with three assists coming off the bench. Brice Sensabaugh chipped in with 25 points with six assists. Utah surrendered 56% shooting to the Thunder with 56% from three. Minnesota improved to 48-33 with their 117-91 home victory to Brooklyn. The Timberwolves hit 55% with 35% from three. Rudy Gobert produced 35 points with 11 rebounds. Julious Randle contributed 21 points with four rebounds. Minnesota allowed 37% shooting to the Nets with 29% from three.

SpaceTime Series 28 Episode 44The Astronomy, Space and Science News PodcastNew Discoveries About Uranus, the 2025 Space Environment Robert on Space Junk, and NASA's Starliner Testing UpdatesIn this episode of SpaceTime, we explore groundbreaking insights into the atmosphere of Uranus, derived from two decades of observations by NASA's Hubble Space Telescope. Uranus, an ice giant with its unique tilt and rotation, reveals complex atmospheric dynamics that scientists are just beginning to understand. We discuss the implications of Hubble's findings, including the distribution of methane and the changing aerosol structures as the planet approaches its northern summer solstice in 2030.The 2025 Space Environment RobertNext, we delve into the European Space Agency's 2025 Space Environment Robert, highlighting the growing challenge of space debris orbiting Earth. With thousands of defunct satellites and rocket stages contributing to the clutter, we examine the risks posed to operational spacecraft and the urgent need for international debris reduction measures. The report underscores the potential for catastrophic chain reactions in space, known as Kessler Syndrome, and the pressing need for sustainable practices in orbit.Nasa and Boeing's Starliner Testing PreparationsAdditionally, we provide updates on NASA and Boeing's ongoing efforts to address issues with the CST-100 Starliner spacecraft. Following a series of test flight challenges, the teams are preparing for new evaluations and propulsion system tests aimed at certifying Starliner for future crewed missions. We discuss the history of Starliner's difficulties and what lies ahead in its journey to becoming a reliable transport vehicle for astronauts.00:00 Space Time Series 28 Episode 44 for broadcast on 11 April 202500:49 New insights into Uranus's atmospheric dynamics06:30 Hubble's long-term observations and their implications12:15 Overview of the 2025 Space Environment Robert18:00 The growing threat of space debris22:45 NASA and Boeing's Starliner testing updates27:00 Summary of recent space exploration developments30:15 Science report: Microplastics and health impactswww.spacetimewithstuartgary.comwww.bitesz.com

Oklahoma City Thunder vs. Utah Jazz NBA Pick Prediction by Tony T. Thunder vs. Jazz Injuries Caruso, Dieng, Dort, SGA, Hartenstein, Holmgren, Wallace and Williams are out for OKC. Collins, Harkless, Kessler, Markkanen and Martin are out for Utah with Collier questionable. Recent Box Score Key Stats Thunder at Jazz 9:30PM ET—Oklahoma City improved to 66-15 following their 125-112 road win at Phoenix. Thunder shot 52% with 40% from three. Jaylin Williams scored 33 points with seven rebounds. Alex Caruso chipped in with 19 points and five rebounds. OKC allowed 48% shooting to the Suns with 36% from three. Utah is 17-63 after their 133-126 home victory to Portland. The Jazz shot 51% with 42% from three. Kyle Fillipowski scored 30 points with 18 rebounds. Brice Sensabaugh collected 22 points with four assists. Utah allowed 46% shooting to the Trailblazers with 24% from three.

Space Nuts Episode 511: Dust Devils on Mars, Space Junk Solutions, and Galaxy Growth ConundrumsIn this captivating episode of Space Nuts, host Heidi Campo fills in for Andrew Dunkley, joining astronomer Professor Fred Watson to explore some of the most intriguing cosmic topics. From the fascinating dust devils observed on Mars to innovative solutions for space debris and the surprising behavior of distant galaxies, this episode is packed with insights that will leave you pondering the mysteries of the universe.Episode Highlights:- Dust Devils on Mars: Heidi and Fred delve into the unique phenomenon of Martian dust devils, discussing how they differ from those on Earth and their significant impact on Mars' surface, including the surprising discovery of lightning within these swirling dust columns.- Space Junk Solutions: The duo examines the growing problem of space debris and introduces a groundbreaking technology from Perseus Space that utilizes electrodynamic tethers to help clean up our orbits, offering a sustainable approach to managing space junk.- Galaxy Growth Conundrums: Fred shares insights from the latest findings of the James Webb Space Telescope, revealing unexpected results about the growth of early galaxies and the implications for our understanding of cosmic evolution.- Multiverse Theories: The conversation takes a speculative turn as Heidi and Fred discuss the intriguing concept of the multiverse and how it challenges our understanding of the cosmos and the laws of physics.For more Space Nuts, including our continually updating newsfeed and to listen to all our episodes, visit our website. Follow us on social media at SpaceNutsPod on Facebook, X, YouTube Music Music, Tumblr, Instagram, and TikTok. We love engaging with our community, so be sure to drop us a message or comment on your favorite platform.If you'd like to help support Space Nuts and join our growing family of insiders for commercial-free episodes and more, visit spacenutspodcast.com/aboutStay curious, keep looking up, and join us next time for more stellar insights and cosmic wonders. Until then, clear skies and happy stargazing.(00:00) Professor Fred Watson joins us to discuss the latest Space Nuts podcast(00:40) It's been quite windy here, but the weather's been nice(01:04) The Spaceflight Human Optimization and Performance Summit is happening this month(02:18) Fred Seibert talks about light pollution in Arizona(03:41) People may not be as familiar with some of the dust storms on Mars(11:47) Mars has such a thin atmosphere that it's not a place to colonize(13:23) New technology could help us deal with space debris and junk in orbit(15:52) Perseus Space is developing a new weapon against space junk(20:46) The James Webb Space Telescope is looking very much at very distant galaxies(26:44) Astronomers and cosmologists talk about the multiverse theory(34:35) Fred: We have very exciting time at the moment in human space flightFor commercial free editions, become a supporter of this podcast: https://www.spreaker.com/podcast/space-nuts-exploring-the-cosmos--2631155/support.

Lisa Kessler, with two decades of professional tarot experience, is the creator of the Practical Tarot Deck and the author of The Practical Tarot Method: Learning to Read Tarot Cards Intuitively. She offers readings globally and teaches her practical tarot approach both in person and online.A dedicated educator, Kessler also developed "Tarot for Writers," a course presented at numerous writers' conferences, aimed at fostering creative intuition. Her YouTube channel features free weekly tarot readings.The Practical Tarot Method empowers readers to confidently connect with their intuition and understand the cards, using tarot as a tool for spiritual guidance. The book provides practical exercises and diverse applications, including meditation, journaling, and creative inspiration. It also features Kessler's inclusive Practical Tarot deck, showcasing a wide range of human diversity, with a 32-page color insert displaying the full deck.For more, visit: https://www.authorlisakessler.com/Send us a textSupport the show Contact me at: postcardstotheuniverse@gmail.com Shout out and follow on IG - @postcardstotheuniverse https://linktr.ee/postcardstotheuniverse Thank you and keep listening for more great shows!

In this episode of Insights from the Couch, we're joined by Dr. Kelly Kessler, a physical therapist and transformation coach, who's on a mission to help high-achieving women break free from self-abandonment and stress. Kelly shares her own journey of moving from a life of chronic self-sacrifice to one of self-honor and balance, offering strategies that can help you find your way back to yourself. She talks about nervous system regulation, the power of breath work, and why setting boundaries is essential to reclaiming your well-being. Together, we uncover why it's crucial for women to prioritize their emotional and physical health, even in the midst of busy, driven lives. From techniques like the physiological sigh to embracing your inner critic with compassion, Dr. Kessler's approach is both gentle and transformative. Tune in for practical tips, grounding insights, and actionable steps to start putting yourself first. Episode Highlights:[0:00] – Welcome and introduction to Dr. Kelly Kessler's background and mission.[1:14] – Kelly shares her journey from self-abandonment to self-care and transformation.[4:33] – Defining self-abandonment and how it impacts high-functioning women.[6:51] – Recognizing patterns of perfectionism and external validation in personal and professional lives.[9:48] – Breathwork as a gateway to slowing down and self-connection.[12:33] – Starting small: how breathwork and gentle exercise initiated Kelly's healing journey.[15:39] – Introducing the “physiological sigh” breath technique and its calming effects.[20:30] – Exploring the connection between body, mind, and anxiety management.[23:38] – Taming the inner critic and cultivating self-compassion through daily practices.[27:46] – The role of boundaries in self-care and why they're essential for personal peace.[34:08] – The grief of setting boundaries and the empowerment it brings.[38:27] – Final takeaways: honoring yourself as a non-negotiable priority. Resources:Dr. Kelly Kessler's Website – Optimal You Health and Wellness – Find resources, coaching, and programs for personal transformation.Free Guide: Eight Daily Practices for Self-Loyalty and Nervous System Harmony – Available on her website.Follow Dr. Kelly on Instagram: @drkellykessler

Portland Trailblazers vs. Utah Jazz NBA Pick Prediction by Tony T. Trailblazers vs. Jazz Injuries Grant, Ayton and Henderson are out for Portland. Avdija, Reath and Simons are questionable. Collins, Harkless, Kessler, Markkanen and KJ Martin are out for Utah with Collier questionable. Recent Box Score Key Stats Trailblazers at Jazz 9PM ET—Portland improved to 35-44 following their 120-109 home victory to San Antonio. The Trailblazers shot 47% with 37% from three. Toumani Camara scored 23 points with ten rebounds. Shaedon Sharpe chipped in with 21 points and ten rebounds. Portland allowed 43% shooting to the Spurs with 32% from three. Utah fell to 16-63 with their 142-134 road defeat to Atlanta. The Jazz shot 52% with 43% from three. Collin Sexton led the starters with 27 points and six assists. Keyonte George got 35 points off the bench with four rebounds. Utah allowed 57% shooting to the Hawks with 54% from three.

Trader Joe's and Aldi grow their foothold on one-stop shopping. Coburn's buys a pair of Kessler's Food stores in South Dakota. And discount grocers go head to head as tariff fears escalate.

Utah Jazz vs. Atlanta Hawks NBA Pick Prediction by Tony T. Jazz vs. Hawks Injuries Collins, Kessler and Markkanen are out for Utah with Martin questionable. Capela and Toppin are out for Atlanta. Recent Box Score Key Stats Jazz at Hawks 8PM ET—Utah drops to 16-62 with their 140-112 road defeat to Indiana. The Jazz shot 38% with 31% from three. Collin Sexton scored 27 points with three assists. Keyonte George pitched in with 15 points and eight rebounds. Utah allowed 575 shooting to the Pacers with 38% from three. Atlanta is on a back-to-back after hosting the Knicks on Saturday and losing 121-105 to fall to 36-41. The Hawks shot 47% with 31% from three. Trae Young produced 16 points with nine assists. Caris LeVert off the bench chipped in with 14 points with four rebounds. Atlanta allowed 54% shooting to the Knicks with 52% from three.

Ryder Kessler and Catherine Vaughan, co-founders of Abundance New York, joined the show to discuss the "abundance" wave washing over the national political discourse (in part inspired by the new book Abundance by Ezra Klein and Derek Thompson), what their vision for abundance in New York is, how to achieve it, NIMBYism vs YIMBYism, and much more. Their group is a relatively new nonprofit group (501c4) creating a new political community and working to influence politics and policy to increase the supply of housing, transit, public space, and clean energy. (Ep 491)

Retired Treasury bond manager Robert Kessler has always been skeptical of Wall Street's "stocks for the long term" mantra. He explains why he is completely out of stocks in his personal portfolio—and why you should consider doing the same.WEALTHTRACK episode 2140 broadcast on April 04, 2025

Utah Jazz vs. Indiana Pacers NBA Pick Prediction by Tony T. Jazz at Pacers Injuries Collins, Kessler and Markkanen are out for Utah. Mathurin, Nesmith and Siakam are questionable for Indiana. Recent Box Score Key Stats Jazz at Pacers 7PM ET—Utah drops to 16-61 following their 143-105 road defeat at Houston. The Jazz shot 43% with 25% from three. Isaiah Collier got 22 points with ten assists. Collin Sexton chipped in with 18 points and four assists. Utah allowed 54% shooting to the Rockets with 42% from three. Indiana improved to 45-31 after their 119-105 home victory over Charlotte. The Pacers shot 49% with 41% from three. Tyrese Haliburton posted 22 points with ten assists. Aaron Nesmith contributed 16 points and three rebounds. Indiana allowed 53% shooting to the Hornets with 42% from three.

When life feels overwhelming, God invites us into deeper spiritual practices—like fasting—to experience His power and presence. In this message, we explore how fasting isn't just about going without food; it's about growing in holiness and amplifying our prayers. Drawing insights from Scripture and powerful moments in history, we see how fasting aligns our hearts with God, transforms our desires, and allows us to experience breakthroughs we never thought possible. Whether you're facing struggles, seeking direction, or longing for a miracle, fasting can open the door to God's intervention. Watch now and discover how embracing this spiritual discipline can bring fresh clarity and strength to your faith.

Utah Jazz vs. Houston Rockets NBA Pick Prediction by Tony T. Jazz vs. Rockets Injuries Collins, Markkanen and Williams are out for Utah. Kessler, Sexton and Springer are questionable. Houston has a clean injury report. Recent Box Score Key Stats Jazz at Rockets 8PM ET—Utah fell to 16-60 following their 110-106 road defeat at Charlotte. The Jazz shot 41% with 27% from three. Keyonte George scored 20 points with four assists off the bench. Brice Sensabaugh got 19 points with five assists. Utah allowed 54% shooting to the Hornets with 39% from three. Houston drops to 49-27 after their 104-98 road defeat to LA Lakers. The Rockets hit 42% with 31% from three. Amen Thompson posted 20 points with five rebounds. Dillon Brooks collected 20 points with five boards. Houston held LA to 35% shooting with 35% from three.

Send us a textA preview and prediction of the impending House settlement, featuring the lead lawyers from both sides.  Rakesh Kilaru (lead counsel for the NCAA) and Jeffrey Kessler (lead counsel for the House plaintiffs) join me to break down everything you need to know about this historic settlement.Thank you for listening! For the latest in sports law news and analysis, you can follow Gabe Feldman on twitter @sportslawguy .

After the 2015 Women's World Cup, the US Women's National Team used their heightened profile and propensity for activism to file a complaint  with Equal Employment Opportunity Commission (EEOC) against US Soccer seeking equal pay to their male counterparts on the US Men's National Team. Five players -- Alex Morgan, Hope Solo, Carli Lloyd, Megan Rapinoe, and Becky Sauerbrunn -- asserted that the US Soccer Federation's payment structure unfairly favored male players, resulting in women earning significantly less than their male counterparts for similar work. Jeffrey Kessler, maybe the world's most prominent sports attorney, became the legal anchor  to the USWNT efforts then and would remain so moving forward.That complaint went unresolved but was the first step in a series of actions that ultimately brought the USWNT a victory. After a reconfiguration of the players union, and a few iterations of collective bargaining agreement negotiations, the women took charge of the fight for equal pay. And leading up to the 2019 Women's World Cup, they decided to escalate the conflict, working with Kessler to file a lawsuit against US Soccer -- this time in the name of 28 players on the national team roster at the time. Filed on International Women's Day, the suit sought backpay and damages, in addition to equal pay moving forward. It would take three years to resolve, but eventually the women emerged victorious, settling with US Soccer for a landmark $24M. Kessler joined Founding Futbol to share his experience supporting the USWNT in their pursuit of equality. He talks about how he ended up in sports law,  when he first connected with the team and so much more. Founding Futbol is a year-long exploration of the critical moments that have led to soccer's emerging popularity in America.Visit our website for more information: ⁠⁠FoundingFutbol.com. Email us at kent@foundingfutbol.com.Subscribe to Founding Futbol on your platform of choice.Host: Kent MalmrosGuest: Jeffrey Kessler (Sports Attorney, Co-Executive Chairman of Winston & Strawn)Learn more about your ad choices. Visit podcastchoices.com/adchoices

Claudia Kessler ist Initiatorin der Initiative “Die Astronautin”. Dass die 29-Jährige Rabea Rogge mit einer Space-X-Rakete ins All fliegt, findet sie erstmal gut. Doch dass die Berlinerin von einem Krypto-Milliardär eingeladen wurde, sende das falsche Signal an junge Frauen. Kessler, Claudia www.deutschlandfunkkultur.de, Fazit

Utah Jazz vs. Charlotte Hornets NBA Pick Prediction by Tony T. Jazz at Hornets Injuries Markkanen, Kessler and Collins are out for Utah with Sexton probable. Curry, Green and Williams are out for Charlotte with Baugh probable. Recent Box Score Key Stats Jazz at Hornets 7PM ET—Utah fell to 16-59 with their 129-93 road defeat to Denver. The Jazz shot 35% with 18% from three. Collin Sexton scored 20 points with two assists. Keyonte George off the bench contributed 20 points and two assists. Utah allowed 58% shooting to the Nuggets with 38% from three. Charlotte fell to 18-56 with their 98-94 road defeat at New Orleans. The Hornets shot 35% with 24% from three. Miles Bridges scored 20 points with six rebounds. Nick Smith off the bench posted 19 points with four rebounds. Charlotte allowed 41% shooting to the Pelicans with 29% from three.

Breaking down the latest Jazz games and predicting the next week of games as the season winds down. Awarding our player of the week and discussing the recent Kessler 3pt experiment. Talking March Madness and how our brackets are holding up going into the elite eight. IG: tunedinjazz

What does it truly mean to have the mindset of Christ? In Philippians 2:1-11, Paul calls us to a life of humility, unity, and selflessness, just as Jesus modeled for us. This message unpacks how Christ, though fully God, chose to lower Himself, serving others and ultimately giving His life for us. His humility wasn't weakness—it was power under control, a love so deep it changed everything. If we want to reflect Jesus in our daily lives, we must embrace this same mindset. Watch now to discover how following Christ's example can transform your relationships, your faith, and your purpose.

This week Linden talks about methane as a greenhouse gas, and a new study showing that rivers with more waterfalls release more methane; and Stu runs us through the different parts of our immune system, including a recently discovered power of proteasomes within cells helping to attack invading bacteria.  Rust, R.L., Frizzell, A. & Kessler, J.D. Waterfalls enhance regional methane emissions by enabling dissolved methane to bypass microbial oxidation. Commun Earth Environ 6, 140 (2025). https://doi.org/10.1038/s43247-025-02060-3  Goldberg, K., Lobov, A., Antonello, P. et al. Cell-autonomous innate immunity by proteasome-derived defence peptides. Nature (2025). https://doi.org/10.1038/s41586-025-08615-w  

Washington Wizards vs. Utah Jazz NBA Pick Prediction by Tony T. Wizards vs. Jazz Injuries Bey, Brogdon, Middleton and Smart are out for Washington. Poole is doubtful with George questionable. Collins, Kessler, Martin, Myhailuk and Springer are out for Utah. Recent Box Score Key Stats Wizards at Jazz 9PM ET—Washington fell to 15-52 following their 112-97 road defeat to Portland. The Wizards shot 41% with 30% from three. Alex Sarr got 20 points with four rebounds. Tristan Vukcevic pitched in with 17 points and eight rebounds off the bench. Washington allowed 42% shooting to the Trailblazers with 33% from three. Utah drops to 15-54 with their 111-97 home defeat to Chicago. Jazz connected 41% with 21% from three. Lauri Markkanen posted 16 points with two rebounds. Keyonte George off the bench pitched in with 16 points and two assists. Utah allowed 43% shooting to the Bulls with 31% from three.

Send us a textIn this episode of Mecca of Banter, we dive into the latest football action from around the globe. STL City secured a thrilling 1-0 victory over Seattle, thanks to a stunning free kick by Lowen. We discuss the game's highlights and debate whether Kessler truly was the man of the match. In the Carabao Cup, Newcastle made history with a 2-1 win over Liverpool, marking their first trophy in over 50 years. We break down the key moments and what this victory means for the club's future.Turning to the Premier League, Arsenal edged out Chelsea with a 1-0 win, Fulham stunned Spurs with a 2-0 victory, and Manchester United dominated Leicester 3-0. We analyze the implications of these results on the league standings. In European competitions, Spurs and United advanced, Real Madrid triumphed over Atletico, and Liverpool faced a tough exit against PSG. We review the matches and look ahead to the next round.Join us for all this and more as we unpack the latest football news and stories!Support the show

As we put more and more satellites in orbit, chances of them colliding also increase. How can we manage that? How can we make sure that Kessler syndrome won't happen and keep all those satellites from destroying each other? Finding out in this interview.

As we put more and more satellites in orbit, chances of them colliding also increase. How can we manage that? How can we make sure that Kessler syndrome won't happen and keep all those satellites from destroying each other? Finding out in this interview.

Bonefishing is one of the most thrilling saltwater experiences an angler can have, and planning a DIY trip adds an extra layer of challenge and reward. Whether you're heading to the Bahamas, Belize, or Mexico, a self-guided flats fishing adventure requires careful planning and a strategic approach. In this guide, based on insights from seasoned DIY angler Ross Kessler, we'll cover everything you need to know to execute a successful DIY bonefish trip—from planning and tides to gear and tactics. For many anglers, DIY bonefishing is the ultimate test of skill and preparation. Instead of relying on a guide, you take full responsibility for finding fish, choosing the right fly, and executing the perfect cast. It's an adventure that requires patience, observation, and a bit of trial and error. Show notes: In this episode of the Saltwater Edge podcast, host Peter Jenkins talks with Ross Kessler, a seasoned DIY bonefish angler with about 20 years of experience. They discuss various tackle tactics, key observations, and best practices for DIY inshore fishing trips, diving deep into fisheries management, conservation, and specific destinations. Ross shares invaluable tips on trip planning, including the importance of tides, preparation, logistics, gear, and the significance of short-game casting, among other insights. They also touch on the role and benefits of hiring local guides to enhance the fishing experience. The episode is packed with practical advice for passionate anglers looking to embark on their own DIY fishing adventures. 00:00 Introduction to the Saltwater Edge Podcast 00:35 Guest Introduction: Ross Kessler 01:06 The Appeal of DIY Fishing 02:50 Planning Your DIY Fishing Trip 05:18 Tides and Timing 10:57 Packing and Preparation 14:24 Navigating and Accessing Fishing Spots 26:30 Essential Gear for Solo Fishing 26:45 Staying Hydrated and Cool 28:37 Clothing and Sun Protection 29:10 Fishing Gear Essentials 31:23 Fly Selection and Techniques 33:49 The Importance of Local Guides 36:24 Casting Techniques and Tips 42:39 Fly Recommendations for DIY Trips 49:31 Conservation and Ethical Fishing 51:13 Final Thoughts and Farewell

In this episode, we talk with career coach Pippi Kessler and financial coach Hadassah Damien about navigating career and financial shifts to create a more fulfilling life. We explore expanding your sense of possibility, embracing change, and breaking the myth that work only counts if it's a grind. If you're feeling stuck and ready for a change, Pippi and Hadassah offer insightful, practical advice delivered with warmth and humor. For more on redesigning your work and financial life, check out their podcast series, Have a Nice Life.LOVELINK is hosted by Brooklyn-based therapists Dr. Signe Simon and Dr. Simone Humphrey. If you'd like to contact us directly, send us an email to info@modernmind.co. 

Con Carlos Artiles, Nelson Moran, y Dan Clayton.

Imagine your dentist as a key player in preventing and managing chronic diseases, not just treating cavities. In this episode, Dr. Brett Kessler advocates for dental benefit reform to shift dentistry from a surgical model to one focused on chronic disease management and overall health, expanding Medicaid benefits and providing care to 300,000 underserved patients. He emphasizes the connection between oral and overall health, aiming to improve patient outcomes and reduce costs by integrating dentistry into broader healthcare systems. Tune in to learn how dentistry is evolving beyond the drill, tackling substance abuse, reshaping healthcare policies, and proving that oral health is the gateway to overall wellness! Watch the entire episode on YouTube and get more details at Think Oral Health Resources: Connect with and follow Dr. Brett Kessler on LinkedIn. Follow the American Dental Association on LinkedIn and explore their website! Watch the entire episode on YouTube and get more details at Think Oral Health. Mariya Filipova - https://filipova.health/ Systemic Health Investor - https://www.4100dx.com/ Care Convergence Thought Leader: Dental Economics Forbes Technology Council Member Jonathan Levine - www.drjonathanlevine.com Founder - JBL New York City www.jblnyc.com Founder - GLO Science LLC www.gloscience.com Co-Founder - GLO GOOD Foundation www.glogoodfoundation.org

What if your struggles aren't just obstacles but opportunities? In Philippians 1:19-30, Paul reminds us that to live is Christ and to die is gain. He shows us how to face suffering with confidence, knowing that God is using every moment for His glory. This message challenges us to wake up to the spiritual reality we're living in and trust that God is working—even when we can't see it. Watch now and be encouraged to stand firm in your faith! Like, share, and subscribe for more biblical truth.

The roots of the current conflict in Gaza trace back to the Balfour Declaration and earlier, but also to a series of ethnic killings and counterattacks in the years just before Israel became a state. Oren Kessler joins us to discuss Palestine 1936: The Great Revolt and the Roots of the Middle East Conflict. Plus, Trump's latest tariff chaos has Canadians resorting to some choice words. And in The Spiel, we examine the status of the most aggressive initiatives of the Trump administration. Produced by Corey Wara Email us at thegist@mikepesca.com To advertise on the show, contact sales@advertisecast.com or visit https://advertising.libsyn.com/TheGist Subscribe to The Gist: https://subscribe.mikepesca.com/ Subscribe to The Gist Youtube Page: https://www.youtube.com/channel/UC4_bh0wHgk2YfpKf4rg40_g Subscribe to The Gist Instagram Page: GIST INSTAGRAM Follow Mikes Substack at: Pesca Profundities | Mike Pesca | Substack  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Join EGM Labs now: https://jamiephillips.graphy.com/membership#nav_bar Join the FREE Goalie Newsletter! EGMWeekly.beehiiv.com Join Team EGM. The first and only Goalie Performance Club: https://www.elitegoaliemethod.com/

Tired of overcomplicating your content creation? In this episode of Launch Your Private Podcast, Kaitlyn Kessler—energetics and business coach for visionary leaders reveals how she transformed her business by replacing traditional LMS systems with private podcasting. Learn how audio became her #1 tool for aligning her content delivery with her mission of simplicity, ease, and sustainable growth.Timestamps:[0:00] Introduction to the episode and Kaitlyn Kessler's journey in creating her first audio-based course[7:30] Transitioning away from traditional course platforms: Canceling LMS subscriptions for audio-only delivery.[12:20] Organic vs. paid marketing for private podcasts: Crushing signup goals with a free audio lead magnet.[14:10] The psychology behind going fully audio-first: Why simplicity aligns with client lifestyles.[16:00] Addressing practical concerns in the transition to going fully audio[24:30] The biggest mindset shift: Letting go of “more is more” and focusing on what's actually used.[27:15] The biggest mindset shift: Letting go of traditional formats[34:30] The emotional impact of audio-based learning: Building trust through voice and embodied content.Links mentioned:instagram.com/kaitlynskesslerhttps://kaitlynkessler.com/bwekaitlynkessler.com

Hour One of the Good Morning Football Podcast begins with hosts Jamie Erdahl, Kyle Brandt, Cody Kessler and D’Marco Farr examining what’s best for Sam Darnold and the Minnesota Vikings. D’Marco lists his favorite DT’s and then they discuss Jimmy Johnson’s legacy following his retirement at Fox Sports. Kessler’s Nightmare - Cody talks us through some of the toughest moments of his NFL career.See omnystudio.com/listener for privacy information.

In this episode, we begin by discussing the counselling issues and interventions raised in episode 2: Countertransference. We'll then present this week's case, where the genetic counsellor experienced their first predictive testing results disclosure in neurogenetics. Support us by buying a coffee: https://buymeacoffee.com/gcchatpod Sound engineer: Shaun Allen You will find suggestions for support, our privacy statement and disclaimer, and more information about topics referenced in our discussion on our website. https://gcchatpodcast.libsyn.com/  You can find us on Instagram, Facebook and Bluesky. Join the discussion with #GCchatpodcast References mentioned in our discussion: Clark, (2010). Life as a pregnant genetic counselor. Journal of Genetic Counseling https://doi.org/10.1007/s10897-010-9283-3. Clark, (2012). Life as a pregnant genetic counselor: take two. Journal of Genetic Counseling https://doi.org/10.1007/s10897-011-9411-8. Kessler, (1992). Psychological aspects of genetic counseling. VIII. Suffering and countertransference. Journal of Genetic Counseling https://doi.org/10.1007/BF00962826. Menezes et al., (2010). “It's Challenging on a Personal Level”—Exploring the ‘Lived Experience' of Australian and Canadian Prenatal Genetic Counselors. Journal of Genetic Counseling https://doi.org/10.1007/s10897-010-9315-z Menezes, (2012). Commentary on “Life as a Pregnant Genetic Counselor: Take Two”. Journal of Genetic Counseling  https://doi.org/10.1007/s10897-011-9413-6 Menezes et al., (2013), “Taking Its Toll”: The Challenges of Working in Fetal Medicine. Birth https://doi.org/10.1111/birt.12029 Porges, (2017). The pocket guide to the polyvagal theory: the transformative power of feeling safe. USA: Norton & Company. Redlinger-Grosse, (2020). Countertransference. In Genetic Counseling Practice (eds B.S. LeRoy, P.M. Veach and N.P. Callanan). https://doi.org/10.1002/9781119529873.ch8 Rietzler, et al. (2018). Perceived Changes to Obstetric Care and the Integration of Personal and Professional Life as a Pregnant Prenatal Genetic Counselor. Journal of Genetic Counseling, https://doi.org/10.1007/s10897-018-0210-3

Catch “The Drive with Spence Checketts” from 2 pm to 6 pm weekdays on ESPN 700 & 92.1 FM. Produced by Porter Larsen. The latest on the Utah Jazz, Real Salt Lake, Utes, BYU + more sports storylines.

Jazz latest, Kessler big night, prospect development, RSL + more

Genetic testing plays a key role in the evaluation of epilepsy patients. With the expanding number of choices for genetic tests and the complexity of interpretation of results, genetic literacy and knowledge of the most common genetic epilepsies are important for high-quality clinical practice. In this episode, Gordon Smith, MD, FAAN speaks Sudha Kilaru Kessler, MD, MSCE, author of the article “Epilepsy Genetics,” in the Continuum February 2025 Epilepsy issue. Dr. Smith is a Continuum® Audio interviewer and a professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Kessler is an associate professor of neurology and pediatrics at Perelman School of Medicine at the University of Pennsylvania and Children's Hospital of Philadelphia in Philadelphia, Pennsylvania. ADDITIONAL RESOURCES Read the article: Epilepsy Genetics Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the Academy of Neurology: aan.com SOCIAL MEDIA facebook.com/continuumcme @ContinuumAAN  Host: @gordonsmithMD Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME. Dr Smith: Hello, this is Dr Gordon Smith. Today I've got the great pleasure of interviewing Dr Sudha Kessler about her article on epilepsy genetics, which appears in the February 2025 Continuum issue on epilepsy. Sudha, welcome to the podcast and please introduce yourself to our audience. Dr Kessler: Oh, thank you so much. I'm Sudha Kessler. I am a pediatric epileptologist here at the Children's Hospital of Philadelphia and the University of Pennsylvania. Dr Smith: Tell us a little bit about yourself. Are you a geneticist too, or how did you get into this particular topic? Dr Kessler: Yes, I want to emphatically say that I am not a geneticist. I'm not an expert in epilepsy genetics at all. I take care of all sorts of patients with epilepsy. I actually do mostly epilepsy surgery-related care. But this part of epilepsy is, every year, increasingly important to our everyday practice. And I think it's fascinating, often a little daunting. I think I was asked to get involved with this article as a non-expert to help translate from the experts to the rest of us. Dr Smith: We're going to get there, because one of the things you do a really good job of in the article is talking about genetic concepts that are germane to everything we do. And I think you're an expert. You do it in a way that I understood. So, I'd like to get there, but- and this is a really hot area. For instance, I really loved your figure that shows the arc of discovery of genetic causes for epilepsy. It's really breathtaking, something we wouldn't have thought possible that long ago. And it's also a lot to digest. And so, I wonder if maybe we can begin by thinking about a framework and, for instance, you talk about these different groups of disorders. And one that seems to be particularly impacted by this unbelievable A-rated discovery. Our developmental and epileptic encephalopathies, or DEEs. What can you tell our listeners about that group of disorders? Dr Kessler: Sure. I think that, you know, most of what we think about in epilepsy genetics now has to do with disorders that are attributable to changes in a single gene. Genetics is obviously much more complicated than that, but that's still where we are in the stage of discovery. And the graph in the article is definitely one to take a look at because it represents the explosion that we've had in our understanding of single gene disorders leading to epilepsy and related manifestations. The DEEs are a group of disorders where any individual disorder is fairly rare, but as a group they are not that rare, and very impactful because they often cause epilepsy at a very young age. And either as a consequence of seizures or as a consequence of the underlying pathophysiology of that gene change, they are typically associated with really significant developmental impairments for a child 's entire life. Dr Smith: My understanding is that there's therapeutic development going on in this space. So, the early recognition of these genetic testing offers the promise of very impactful treatment---like we now do for SMA, for instance---early in the disease course. Dr Kessler: I think that's right. That's one of the most exciting parts of this field is that so much, just around the corner, for drug development, therapy development in this area. And as you can imagine, with a lot of these disorders, earlier intervention is likely to be much more impactful than later intervention when a lot of the developmental consequences are sort of… you know, when the cat 's already out of the bag, so to speak. Dr Smith: Yeah. So, this is really transformational and something that everyone who takes care of kids with epilepsy needs to know about, it seems. So on the other extreme, I guess, there are the self-limited epilepsies. I didn't really know about this in terms of genetic discovery, but can you talk about those disorders? Dr Kessler: Yeah, sure. I mean, I think some of these are the classic childhood epilepsy syndromes that we think about like childhood absence epilepsy or what we used to call benign romantic epilepsy and now call self-limited epilepsy of childhood with centrotemporal spikes. It's a mouthful, shortened to SeLECTS. Those are the epilepsies that occur typically in previously healthy children, that affects them for a few years and often remits so that epilepsy is just age-limited and doesn't continue for life. They clearly have genetic influences because they tend to run in families, but the genetics of them is not generally single gene associated. And so, we haven't actually explained why most of those kids actually get epilepsy. I think that'll be sort of another interesting area of discovery that will help us even understand some really fundamental things about epilepsy, like, why does this syndrome start at this age and tend to resolve by adolescence? Dr Smith: And the other thing I found interesting is disorders that I might have thought going into it would have a defined genetic cause or some of the disorders that there are not. So JME, for instance, or childhood absence, which is a little counterintuitive. Dr Kessler: It's completely counterintuitive. We call them genetic generalized epilepsies, and we know that they run in families, but we still know so little. I would say of all of the disorders that are mentioned in this article, that is the group where I think we have explained the genetic underpinnings the least well. Dr Smith: Yeah. Isn't that interesting? It's… wasn't it Yogi Berra who said, it's hard to predict things, particularly the future? So… Dr Kessler: Yes. Dr Smith: Who would have thought? So, we've talked a lot about kids. What about adults? You know, what role does genetic testing play in adults who have unexplained epilepsy? Dr Kessler: Yeah, I think that that is also a really important emerging area of knowledge. I think many epileptologists may think of genetic epilepsy as being solely pediatric. There are definitely not how many of these disorders can manifest for the first time in adulthood. Not only that, many of our children with childhood onset epilepsy that is due to a genetic problem grow up to become adults and will then need adult epilepsy care. In order to take care of both of those groups, it's really important for all epileptologists, including those that take care of adults, to have some knowledge of the potential impact of genetic testing. And how do you even approach thinking about it? Dr Smith: The message I guess I'm getting is if our listeners take care of patients with epilepsy, no matter how old those patients are, they need to be familiar with this. And the other message I'm getting is, it sounds like there are a lot of patients who really need genetic testing. And this came through in one aspect of your article that I found really interesting, right? So, what are the recommendations on genetic testing? So, the National Society of Genetic Counselors, as I understand it, said everyone needs genetic testing, right? Which I mean, they're genetic counselors, so. Which is great. In the International League Against Epilepsy, they recommended a more targeted approach. So, what's your recommendation? Should we be testing anyone with unexplained epilepsy, or should we be focusing on particular populations? Dr Kessler: Well, I guess I think about it as a gradation. There are certain populations that really deserve genetic testing, where it is going to be absolutely critical. You know, it's very likely that it will be critical knowledge to their care. If you diagnose somebody with epilepsy and you do imaging and that imaging does not reveal an answer, meaning you don't see a tumor or you don't see an old stroke or some other sort of acquired lesion, the next pillar of testing for understanding underlying etiology is genetic testing. That is the point at which I typically send my patients, and that's whether they're refractory or not. I think in the past some people felt that only patients with refractory epilepsy deserve or require testing. I think the reason why not to limit it to that population is that what's on a person's mind with epilepsy, or a family's mind with epilepsy, is what's going to happen to my child or to me in the future? And if genetic testing can shed some light on that, that will have a huge impact on that person's life. Dr Smith: You've got great cases in your article, which, I just want to give you a compliment. The information and entertainment, frankly, for per page: off the charts. It's not a long article, packed with useful information. And, I mean, some of your cases are great examples of patients who are heading down the surgical epilepsy path and you discovered, nope, there's a genetic cause that really impacted their care. What's the yield, right? The number of patients that you send genetic testing on for epilepsy, what percentage come back positive for a relevant sequence variant that you think is either causing or contributing to their epilepsy? Dr Kessler: That's a great question. I think that is actually still in flux because it depends on the population of patients that are being sent for testing, obviously, and then also on what testing is being done. So, I know in at least one large recent meta-analysis, the overall yield was 17%. And somebody hearing that number might think, oh, that's not very high, but it's actually very comparable to the yield for imaging. And we all do MRIs and patients that have new-onset epilepsy where the yield of MRI testing is about 20%  or so. So, quite comparable. And then with children with DEEs, the yield is much, much higher than that. Dr Smith: So, 17% is actually a really great diagnostic yield. When I think of my yield and doing genetic testing on patients who have an axonal CMT phenotype, right? I mean that's better than what I get. So, good for you. That's exciting. Dr Kessler: It's interesting. I think that maybe an assumption might be that you're working somebody up. You do a genetic test, it reveals a difference, and thus surgery is off the table. It's actually quite different than the head, which is that some results may make surgery be even more “on the table” because you might find a gene that is known to be associated with a propensity to vocal cortical dysplasia, for example. And you may take a good second look at that person's MRI imaging or do other imaging to reveal the MRI invisible vocal cortical dysplasia. Dr Smith: Outstanding point. Let's talk a little more about the genetic testing itself. So, we've got all these genes. We understand when to test. What do you do? For instance, last night I just looked at the company that we use for most of our neuromuscular testing and they have a genetic epilepsy next gen panel with, I don't know, three hundred and twenty genes, right? Do you use that kind of panel? Do you go directly to a whole EXO? What's the right approach? Dr Kessler: Yeah, I think that that is quite dynamic right now, meaning that recommendations seem to change often enough that I rely on help. I have the enormous good luck of working here at CHOP where there is a fantastic epilepsy genetics group that I can easily refer to, and I know not everyone has that resource. The current recommendation is to start with an exome if that is available and is covered by that patient's insurance. When exome is not available, then the next best thing is a gene panel. You know, in recent years there have been a lot of sponsored gene panels, meaning free to the patient, administered by a company that then, you know, has other uses for compiled or grouped genetic data. And I think that as long as all of that can be clearly explained to a patient, and- along with all of the other things so you have to explain to a patient before doing genetic testing, about the pluses and minuses of doing it, I think that you sort of go for the best test you can that's available to that patient. Dr Smith: The sponsored programs can be very, very helpful, particularly from a payer or a patient payment perspective. And so, I guess the lesson there is it's great if you got the resources and CHOP to help you decide, but better to get whatever panel you can get than to do nothing; or, of course, refer to a center if you're not comfortable. Dr Kessler: And also, just know that these things change often enough that if it's been a couple of years and you might want to recheck whether the EXO is available to that patient or whether a gene panel can be sent that includes more than they had eight years ago. Dr Smith: So, are there situations to go to the other extreme where you just do targeted sanger sequencing? Like, just sequence the specific gene of interest?  Dr Kessler: Yeah, absolutely. I'm still a big proponent of thinking clinically about a patient. If there are clues in that patient's history, exam, imaging, anything that gives you some sense of the disorder that this patient might have. And I think a classic example would be tuberous sclerosis. If you see an infant who has new onset spasms, you see hypopigmented macules on their skin and their MRI shows a tuber, you know, also known as a focal cortical dysplasia, then sure, send the targeted sequencing for the TSC1 and TSC2 genes. Dr Smith: And Rett syndrome?  Dr Kessler: And Rett syndrome would be another example. And there are many examples where, if you feel like you have a good sense of what the disorder is, I think it's completely acceptable to send the targeted testing.  Dr Smith: So, I'm going to get further down the rabbit hole and get to from easier to harder. I always get confused about things like chromosomal microarrays or, like, karyotypes and rings and stuff like that. What role do these tests play and what do our listeners need to know about them? Dr Kessler: Yeah, I think that it is really important to have at least some knowledge of what each test can't tell you. I tell my medical students at my residence that all the time. With anything in medicine, you should know what you're asking of a test and what answers a test can tell you and can't tell you. It is baseline knowledge before requesting anything. And if you don't know, then it's best to ask. So, chromosomal microarray is used when you think that there is a large-scale derangement in a bunch of genes, meaning there is a whole section of a chromosome missing---that would be deletion, or that that information is duplicated or is turned around in a, you know, in a translocation. That is what- the kinds of things that that test can tell you. I think of doing a microarray when a child has not just epilepsy and intellectual disability, but also has, for example, other organ systems involved, because sections of chromosome can include many, many, many different genes and it can affect the body in larger ways. That's often when I think about that. So, a child with multiple congenital anomalies. Karyotype, which we think of as the most old-fashioned way of looking at our genes, still has some utility because it is useful for looking at a specific situation where the ends of arm of a chromosome get cut off and get sticky and then stick to each other and make a ring. For example, ring chromosome 20 is a disorder which can cause epilepsy, particularly hard-to-treat frontal lobe epilepsy, and that sometimes doesn't show up until adolescence or even early adulthood. That's just one example of something that karyotype can tell you.  Dr Smith: And it goes without saying, but just to emphasize, these are things that you would miss completely on a next generation panel or a next genome? Dr Kessler: That's correct. Because this isn't about sequencing. This is about large structures. You know, with my patients, it's sometimes, I think, very hard to explain. It's hard enough to explain it to other physicians who aren't in genetics, but it's a whole other undertaking to explain it to families who may not have a lot of literacy about cell biology or genetics or, you know, anything related to that. So, I often rely on analogies. And one analogy I use is that if you're- all of your genetic information is like a book, that book is split into chapters and those are the chromosomes. And you can be missing entire paragraphs or have paragraphs duplicated. And that would be the kind of thing that we would be looking for with the chromosomal microarray with sequencing or, you know, with sequencing, we're looking for spelling of words, and we can look at one word at a time. That would be targeted sequencing. Or we can look at many, many words at a time. And that would be next gen sequencing.  Dr Smith: I just want to say that you are the genetic whisperer. You know, translator. I love it.  Dr Kessler: You can continue using it down to the level of explaining the possibility of a variant of unknown significance, which I think is sometimes difficult to explain. So, I often will say, I know how the word color is spelled: C O L O R. But sometimes in other places it will be spelled C O L O U R and that's still the same word, that's still color. That's just what we would call a population variant. If it is spelled C O M O R, that changes meaning; that is not a word, and that is probably a pathogenic variant. But if it gets misspelled and it's K O L O R, then I'm not sure. Could that be a variant that means something different or not. And so that I would call that a variant of unknown significance, meaning its impact is to be determined. Dr Smith: So, I was going to ask you about variant calling, but you'd beat me to the punch. And that's a great metaphor that I will definitely remember. All right, here's another concept that I think people often find challenging, which is read depth. Can you tell us about reading depth or sequence depth?  Dr Kessler: Yes, hopefully I can. Again, not an expert here, but as I understand it, the way next gen sequencing works is that pieces of DNA are getting read. And the number of times any given nucleotide is read in this process is the read depth. It basically just translates to the number of times the processor, the machinery of doing this, pays attention to anyone site. The reason it's important is that the process by which this reading is done can sometimes result in errors. The greater your depth, the more times something is read, the less likely you are to have a mistake.  Dr Smith: In either direction. So, you're presumably less likely to have a false positive or false negative. Yep, again, very well explained. You know, I've got a lot of other questions I want to ask you, but I do want to be respectful of our listeners' time. I wonder if we could pivot a little bit and just let's go back to where we began. Really exciting time, right? Amazing. And you've been doing this long enough. I'm sure you didn't think when you started that it was going to look like this. What does the future look like? I mean, we talked a little bit about therapeutics, but the world's changing fast. Five, ten years from now, what's your hope for that?  Dr Kessler: Oh, that's such a great question. You know, we are at the point with genetic epilepsies that gene-based therapies, either antisense oligonucleotide-based therapies or viral vector-based gene therapies, are actually now being developed and administered in trial situations to actual patients. And so, it always feels like we're on the cusp, but I think actually now we really are on the cusp of having gene-based therapies for genetic epilepsies. I think that there is still so much to sort out, both from basic scientific point and from a practical administering these things to patients and what are the potential long term consequences.For example, unlike medications, which are therapies that you can stop if there are adverse effects, often administering a gene therapy is a one-and-done thing that can't be retracted. Thinking even about the ethical framework of that and the framework of explaining to patients that we don't know the ten, twenty-year consequences of that, is part of the informed consent process, for example. So, there's still so much work that is going to be transformational, not just from the, you know, the big picture, but from developing all, you know, from going through all of these steps to really make these kinds of therapies a reality. Dr Smith: Well, it's really amazing. And, you know, we're seeing this in multiple different areas in neurology. So, well done. You run the child neurology residency program there, I understand. I try to snoop on people before I talk to them because we haven't met before this. And you're obviously a very a very good educator. Thank you so much for talking with me today. I don't spend a lot of time in epilepsy, but every time I do one of these, I kind of want to go back and do something different because it's such a neat field. Thank you.  Dr Kessler: You're welcome. It was my pleasure.  Dr Smith: Again, today I've been interviewing Dr Sudha Kessler about her article on epilepsy genetics, which is truly outstanding. This article appears in the most recent issue of Continuum on epilepsy. Be sure to check out Continuum audio episodes from this and other issues. And thank you, listeners, for joining us today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

On today's show, we have a lot to talk about. Josh Hoey just ran 1:43.24 for 800 meters—indoors. That's the second-fastest time ever run indoors, behind only Wilson Kipketer. We'll break down what this means for the American 800m scene, how he's addressed skepticism that inevitably comes with a performance like this and whether Hoey is suddenly a legitimate outdoor medal contender.Hobbs Kessler doubled at USAs, taking both the 3000m and 1500m titles like it was just another weekend at the track. We'll talk about what impressed us the most about Kessler's double, how the men's middle distances are shaping up for 2025 and why it was OK for Cooper Teare and Cole Hocker to skip out.And then there's the "rivalry" that was quickly dispelled by the athletes – Nikki Hiltz vs. Shelby Houlihan. Just a few years ago, Houlihan was untouchable. Then came the four-year ban, and now, she's back—and already battling for the top spot. In the 3000m, Houlihan got to the front, squeezed the pace, and dared anyone to come with her. And Nikki Hiltz? They came with her. And then passed her. In the final strides of the women's 3000m, Hiltz outkicked Houlihan, officially stamping themselves as America's best championship racer in the middle distances.Plus, we'll get into the results of the sprints and why the 2025 World Indoor Championships in Nanjing might be one of the weirdest global meets we've ever seen—between withdrawals, travel logistics, and a US team that's missing some of its biggest stars.Host: Chris Chavez | ⁠⁠@chris_j_chavez on Instagram⁠ SUPPORT OUR SPONSORSKETONE-IQ: Level up your training with Ketone-IQ – a clean shot of energy with no sugar or caffeine. Or try the new Ketone-IQ + Caffeine, combining 5g of ketones with 100mg of green tea caffeine for a smooth, sustained boost. It's used by pro runners like Des Linden and Sara Hall. Proven to enhance endurance, focus, and recovery, ketones are 28% more efficient than glucose. No crashes, no bonking—just next-level performance. Take the shot. Feel the difference. Save 30% off your first subscription order & receive a free six pack of Ketone-IQ with ⁠KETONE.com/CITIUS⁠.OLIPOP: BuzzFeed just came out with an article that recently named Olipop "the best overall soda for flavor" — and with a lineup that includes classic root beer, vintage cola and cherry vanilla, it's easy to see why. ⁠Try Olipop today and save 25% on your order using code CITIUS25 at checkout at DrinkOlipop.com.⁠

We're giving everyone 15 minutes of our Supporters Club podcast. Josh Hoey is now the 2nd fastest man ever indoors at 800 and Shelby Houlihan and Hobbs Kessler completed their doubles as Nia Akins is back. The full podcast is for Supporters Club members but you can join today for 50% off your first year with code GOAT50. Money back guarantee. Cancel anytime. https://www.letsrun.com/subscribe Video of podcast here: https://youtu.be/vvS2N4cFEAA Show notes: 0:00 Start 1:53 Hoey's Historic Performance 5:41 Praise for Hoey 10:44 Women's 800: Nia Akins is Back 15:44 Women's 1500: Nikki Hiltz Double 22:51 Men's 1500: Hobbs Kessler Double 29:44 Thougths on Cole Hocker and Cooper Teare's 12:57 32:51 Atmosphere and Final Thoughts Contact us: Email podcast@letsrun.com or call/text 1-844-LETSRUN podcast voicemail/text line. Want a 2nd podcast every week? And savings on running shoes? Join the LetsRun.com Supporters Club today for exclusive content, a bonus weekly podcast, shoe savings, and more. Cancel anytime .https://www.letsrun.com/subscribe Check out the LetsRun.com store. https://shop.letsrun.com/ We've got the softest running shirts in the business. Thanks for listening. Please rate us on your podcast app and spread the word to friend. Send us your feedback online: https://pinecast.com/feedback/letsrun/9b9a38fd-0ba4-4239-9390-98303d4e92ed

If you can't get excited about track from listening to these two talk, then you should have your head examined and your pulse checked! Their enthusiasm for the sport is contagious. In this episode, they start with life updates including recent travels for them both. Des updates us on her trip to Kona and on her Boston prep, and Kara shares about her recent trips for broadcasting. Colt had an amazing opportunity to chase a mile PR at the Armory Track in NYC with the NBC cameras rolling, and Kara gives us the full rundown. Operation #DestroyColt has been officially retired out of necessity! They then turn to all of the recent indoor track action from NB Indoors and Millrose, where the times have been so very FAST, including two world records set by Americans. The discussion includes all of the big names... Hiltz, Morgan, McClain, Houlihan, Kessler, Nuguse, Hocker, Fisher, and so many more. If you missed the races, get your updates here. If you watched, listen in to hear Des and Kara's takes on it all. The track year (and the podcast year) is off to an amazing start.      

Will space debris prevent us from accessing orbit and when could it happen? Is the Universe with all its rules just a lucky accident? What does "The Publisher of Universe Today" even do? Answering all these questions and more in this Q&A show.

Will space debris prevent us from accessing orbit and when could it happen? Is the Universe with all its rules just a lucky accident? What does "The Publisher of Universe Today" even do? Answering all these questions and more in this Q&A show.

Brandon Kravitz and Nick Whalen break down Luka Doncic's debut for the Lakers, who rolled to an easy win over the Utah Jazz. The guys discuss the Lakers' options at center, Luka's fit alongside LeBron and what comes next for Mark Williams and the Hornets. The guys also talk shutdown candidates for the Jazz, Wizards, Pelicans and more. 00:00 Intro 01:00 Quick New Orleans media row recap 05:30 Luka's debut 11:00 Lakers need to add a big man + Luka/LeBron fit 18:00 What to do with Mark Williams 21:40 Shutdown candidates 23:15 Utah Jazz + Collins, Markkanen, Kessler, Sexton 24:05 Wizards + Middleton, Smart, Poole 24:45 Bulls + Blazers 27:20 Pelicans + McCollum, Zion, Murphy 28:45 Walker Kessler 29:45 Trading LaMelo Ball 31:15 Trading Zion + Poole 32:50 Max Christie, Aaron Wiggins 34:15 Drop Tari Eason for Ellis, Wiggins, Beal? ----- EDGE Boost EDGE Boost is the financial platform for smart bettors and DFS players. What are the benefits of a dedicated EDGE Boost betting account? Earn up to 0.5% on every deposit Free to use, no minimum balances FDIC-insured accounts Unlimited withdraws back to card Lightning fast deposits and withdraws Sign up with promo code ROTOPOD today!  ----- Pool Genius Want to win more in your golf, March Madness, and football pools? PoolGenius gives you data-driven picks and strategies to outsmart the competition. RotoWire listeners get exclusive offers! Visit PoolGenius.com/rotowire for up to 55% off, or start a 4-day free trial. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Grant Fisher and Yared Nuguse are world record holders in the 3000 and mile respectively as Cole Hocker and Hobbs Kessler ran faster than anyone else previously in the event. Josh Hoey's amazing 2025 continued with his 2nd American record. Shelby Houlihan ran the 2nd fastest indoor mile by an American in Boston and 16-year-old high school sophomore Cooper Lutkenhaus ran 1:46 at Millrose. We try and tell you what it all means? Want a 2nd podcast every week? And savings on running shoes? Join the LetsRun.com Supporters Club today for exclusive content, a bonus weekly podcast, shoe savings, and more. Cancel anytime .https://www.letsrun.com/subscribe Show notes: 00:00 letsrun.com/subscribe 00:56 Intro 06:46 LetsRun Millrose Watch Party 10:19 Millrose was Amazing 12:53 3000: Grant Fisher world record over Cole Hawker 21:23 Have Fisher and Hocker leveled up? 26:01 Bad news for Jakob? 31:22 Discussion on Track Times and Performances 32:31 Wanamaker Mile: Yared Nuguse world record over Hobbs Kessler 39:30 The other fast Americans 43:38 Text Message of the Week: How fast could Jim Ryun have gone? 47:44 Cam Myers vs Niels Laros vs Jakob Ingebrigtsen 49:51 What about Hobbs Kessler? 51:38 Cole Hawker's the favorite in 1500 for Worlds? 58:19 Grand Slam Track will have 3 of the 4 in 1500, how should they do tv? 01:02:36 Bicarb? 01:05:32 Josh Hoey American record 800 01:13:55 Shelby Houlihan 2nd fastest mile ever by an American indoors 01:18:34 High School Phenom Cooper Lutkenhaus 1:46.86 as 16-year-old 01:20:52 Rapid Fire Rest of Millrose 01:21:01 NIa Akins bombs 01:23:14 Will Sumner and crew impress in 600 01:25:28 Women's 3K: Whitney Morgan's Win & Katelyn Tuohy struggles 01:28:54 Georgia Bell FTW 01:30:09 Another WR for Fisher this weekend in 5000? Contact us: Email podcast@letsrun.com or call/text 1-844-LETSRUN podcast voicemail/text line. Want a 2nd podcast every week? And savings on running shoes? Join the LetsRun.com Supporters Club today for exclusive content, a bonus weekly podcast, shoe savings, and more. Cancel anytime .https://www.letsrun.com/subscribe Check out the LetsRun.com store. https://shop.letsrun.com/ We've got the softest running shirts in the business. Thanks for listening. Please rate us on your podcast app and spread the word to friend. Send us your feedback online: https://pinecast.com/feedback/letsrun/35ed91b1-1232-488b-9fe9-07593cbd3678