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In today's episode, we welcomed Saad Z. Usmani, MD, MBA, FACP, FASCO, to discuss the significance of the January 2026 FDA approval of daratumumab and hyaluronidase-fihj (Darzalex Faspro) in combination with bortezomib (Velcade), lenalidomide (Revlimid), and dexamethasone (VRd) for the treatment of adult patients with newly diagnosed multiple myeloma who are not eligible for autologous stem cell transplant (ASCT).Usmani is chief of Myeloma Service at Memorial Sloan Kettering Cancer Center in New York, New York, and the recipient of the 2025 Giants of Cancer Care award for multiple myeloma.In the exclusive interview, Dr Usmani explained the clinical implications of the regulatory decision that expanded the indication for daratumumab plus VRd to the transplant-ineligible setting, detailed the pivotal data from the phase 3 CEPHEUS trial (NCT03652064) that supported the approval, and provided context for treatment strategies with this regimen in clinical practice.
Recently, Peggy attended the Tandem 2026 meeting in Salt Lake City, Utah. While there, she sat down as a guest on the Eurofins Viracor Transplant Radio podcast. We wanted to share that interview with you. If you'd like to follow their podcast, you can do so at the links below. We learn today from Peggy Burkhard that transplant is not just a medical experience — it's an emotional, creative, and community‑driven journey that patients, caregivers, and families navigate together. Peggy shares how the National Bone Marrow Transplant Link has evolved since its founding in 1992, offering a wide range of free programs that support patients from diagnosis through survivorship. She highlights the often‑overlooked emotional load carried by caregivers and explains how "the Link" (nbmtLINK), builds connection through healing arts sessions, book clubs, lunch‑and‑learn programs, and survivorship education. We hear about their thriving “Marrow Masters” podcast with 160+ episodes and 40,000 downloads, as well as their expanding resources such as Spanish‑language materials, financial guidance books, and partnerships with groups like the GVHD Alliance and Blood Cancer United. Peggy also gives an inside look at GVHD Awareness Day and the organization's growing social media footprint, which helps elevate patient voices and practical wisdom to the global transplant community. Hosted by Kevin Foth of Eurofins Viracor. Episode Links:Peggy Burkhard | LinkedInThe LINK (nbmtLINK)Meredith A. Cowden FoundationGVHD AllianceMarrow Masters Podcast by nbmtLINK Be a Guest on our Show! We're always looking to speak with the transplant community. To be considered, please email ---> Amplify your influence!
Dark starry skies are disappearing due to rapid urbanisation and artificial light pollution.
In this episode of the Life Challenges Podcast from Christian Life Resources, the team discusses a euthanasia-linked face transplant, a proposed transgender Bill of Rights in Congress, Puerto Rico's recognition of unborn children as persons, dementia research on lifelong learning, and the growing influence—and risks—of AI, all examined through a thoughtful, biblical perspective on today's cultural challenges. Barcelona - Face Transplant: https://www.catalannews.com/society-science/item/barcelona-hospital-carries-out-worlds-first-face-transplant-with-a-donor-who-was-euthanizedTransgender Bill of Rights: https://www.congress.gov/bill/119th-congress/house-resolution/1058/textReading and Writing Help Mental Longevity: https://tinyurl.com/27u3nzhyPuerto Rico Declares a Fetus is a Human Being: https://tinyurl.com/22xfa5ncAn AI Date for Valentine's Day: https://tinyurl.com/2yomkm82Support the showThe ministry of Christian Life Resources promotes the sanctity of life and reaches hearts with the Gospel. We invite you to learn more about the work we're doing: https://christianliferesources.com/
Send a textTalk with your friends and family and you might get the impression that a meniscus injury is common. What are the options available for repair? Matthew Kraeutler, M.D., an orthopedic surgeon with Texas Tech Physicians, goes over the options, including a meniscus transplant. He tells us who is a good candidate for a transplant and what recovery is like and what happens if you ignore the injury. Dr. Kraeutler's Previous episodesHip Arthroscopy: Small Incisions, Big ImpactKnee Health Matters: Preservation Before ReplacementHip Preservation Surgery: When and Why to Consider It
The Smart 7 is an award winning daily podcast that gives you everything you need to know in 7 minutes, at 7am, 7 days a week…With over 19 million downloads and consistently charting, including as No. 1 News Podcast on Spotify, we're a trusted source for people every day and we've won Gold at the Signal International Podcast awardsIf you're enjoying it, please follow, share, or even post a review, it all helps... Today's episode includes the following guests:Grace Bell - Womb Transplant recipient and proud mother of Hugo Dr Isabel Quiroga - Clinical Lead for Organ Retrieval at the Oxford Transplant CentreProfessor Richard Smith - Consultant Gynaecologist at the Imperial College Healthcare NHS trust, and founder of Womb Transplant UK Will Guyatt - The Smart 7's Tech Guru Oliver Niggli - Director General of the World Anti Doping Agency Ian Beasley - former Chief Medical Officer for the Football AssociationSebastian Apesteguia - Paleontologist and Researcher at the Azara Foundation in Buenos Aires Dr Euan Ashley - Professor of Genomics and Cardiovascular Medicine at Stanford University, and Chair of its Department of Medicine,Dr Sanjeev Kumar - Medical Oncologist at the Lifehouse Cancer Centre in Sydney Australia Jonathan Haidt - Author of “The Anxious Generation” Sir Keir Starmer - Prime Minister of the United Kingdom Elodie Mandel-Briffer - Associate Professor of Ecology and Evolution at the University of CopenhagenContact us over @TheSmart7pod or visit www.thesmart7.comVoiced by Ciara Revins, written by Liam Thompson, researched by Lucie Lewis and produced by Daft Doris. Hosted on Acast. See acast.com/privacy for more information.
University of Iowa surgeon Dr. Ramy El-Diwany performed the first robotic living donor nephrectomy, which will lead to more precise surgeries and quicker recovery for kidney donors. UIHC hopes this will mean more living kidney donations. On this News Buzz edition, Ben Kieffer speaks with Dr. El-Diwany, but first, we get a legislative update from Statehouse reporter Katarina Sostaric, Clark Kauffman shares a recent First Amendment case in Newton, and we meet one of the Coralville residents who organized against the city's recently rescinded AI-camera contract.
CardioNerds (Dr. Jenna Skowronski [Heart Failure Council Chair], Dr. Shazli Khan, and Dr. Josh Longinow) are joined by renowned leaders in the field of AHFTC (Advanced Heart Failure and Transplant Cardiology) and mechanical circulatory support, Dr. Jeff Teuteberg and Dr. Mani Daneshmand to continue the discussion of advanced heart failure therapies by taking a deep dive into the world of durable LVADs (Left Ventricular Assist Devices). In this episode, we will review the history of ventricular assist devices, the basics of LVAD function, selection criteria for LVAD therapy, and surgical nuances of LVAD implantation. Audio Editing by CardioNerds intern, Joshua Khorsandi. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Heart Success Series PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls There have been significant advances in the field of MCS/LVAD therapy since the first implanted LVAD in the 1960s, to the first FDA approved device in the early 2000's, to now the HM3 LVAD, with the most important change being a centrifugal flow/magnetically levitated design that led to minimized hemocompatibility-related adverse events (HRAE's) (MOMENTUM 3 trial comparing HM2 and HM3). The REMATCH trial in 2001 was a pivotal trial for LVAD therapy, demonstrating that in a population of patients with advanced HF (70% IV inotrope dependent), LVAD therapy significantly improved survival at both 1 and 2 years as compared to medical therapy alone. MOMENTUM 3 trial was a landmark trial for the HM3 device, showing that in a population of end stage HF patients (86% inotrope dependent, 32% INTERMACS 1-2, and 60% DT strategy), 5-year survival with HM3 was 58% and HM3 had lower HRAE's compared with HM2. There are both patient-specific factors and surgical considerations when it comes to candidacy for LVAD therapy. RV function prior to LVAD is a key determinant for success post-LVAD Many patients being considered for LVAD may not have robust RV function, however, predicting RV failure after LVAD is exceedingly difficult. In general, it doesn’t matter how bad the RV may look on imaging; we care more about the pre-LVAD hemodynamics (look at the PAPi and RA/wedge ratio). What happens in the OR may be the most important determinant of how the RV will do with the LVAD! Notes Notes drafted by Dr. Josh Longinow. 1. Historical background of heart pumps and LVADs LVAD Evolution FDA approval year 2001 2008 2012 2017 Pump HeartMate XVE HeartMate II Heartware HVAD HeartMate III Flow/Design Features Pulsatile Technology Continuous flow Axial design Continuous flow Centrifugal design Continuous flow Full MagLev + Centrifugal design The 1960's ushered in the first ‘LVADs', when the first air-powered ‘LVAD' was implanted. It kept the patient alive for four days before the patient expired. The first generation of LVADs were pulsatile pumps The first nationally recognized, FDA approved LVAD was the HeartMate XVE (late 1990s to early 2000s, REMATCH trial). The XVE pump used compressed air (pneumatically driven) to power the pump. Prior to the XVE, OHT was the standard of care for patients with advanced, end-stage heart failure. The second and third generations of LVADs were non-pulsatile, continuous flow devices and included the HVAD, HM2, and HM3 devices. MOMENTUM 3 was a landmark trial for the HM3 device, showing that in a population of sick patients with end stage HF (86% inotrope dependent, 32% INTERMACS 1-2, and 60% DT strategy), 5-year survival with HM3 was 58% and HM3 had lower HRAE's compared with HM2. The only pump that is currently FDA approved for implant is the HM3, although other pumps are in clinical trials (BrioVAD system, INNOVATE Trial). 2. What are LVADs, and how do they work? In simplest terms, the LVAD is a heart pump comprised of several key mechanistic components: Inflow cannula Mechanical pump Outflow cannula Driveline Controller/Power source The HM3 differs from its predecessors (HM2 and HVAD) in several key ways; HM3 is placed intrapericardial whereas the HM2 was placed pre-peritoneal. Perhaps most importantly, the HM3 is a fully magnetically levitated, centrifugal flow pump, whereas the HM2 is an axial flow device. Axial flow pumps are not magnetically levitated, leading to more friction produced between the ruby bearing's contact with the pump rotors, and higher rates of hemocompatibility related adverse events (HRAEs, i.e. pump thrombosis) and the HM2 was ultimately discontinued in favor of the HM3 (MOMENTUM 3 trial). 3. What do the terms ‘Destination Therapy' (DT) or ‘Bridge to Transplant' (BTT) mean when it comes to LVADs? When LVADs first came on the stage, EVERYONE was a BTT; these early pumps weren't designed for long term use (I.e. REMATCH Trial, Heartmate XVE) Destination therapy means the LVAD was placed in leu of transplant because there are contraindications to transplant REMATCH trial brought about the concept of “Destination therapy”, comparing outcomes in patients (with contraindications for transplant) who received an LVAD vs optimal medical therapy Bridge to transplant means we are placing the LVAD in a patient who may not be a transplant candidate at this moment in time (is too sick, or conversely, not sick enough), but may be down the line Bridge to recovery is another term used when the LVAD is being placed for a patient we think may have a recoverable cardiomyopathy 4. What are some factors we should consider when assessing a patient’s candidacy for LVAD, in general, and from a surgical perspective? Patient factors Older age might push us towards thinking LVAD rather than transplant In general, age > 70 is the cutoff for transplant, but this is not a hard cut off and varies institution to institution In general, think about things that help predict recovery after a major surgery; Frailty and Nutritional status are important, we try to optimize these prior to LVAD implant Right ventricular function remains the Achilles heel of LV support We know that needing temporary RV support post LVAD puts you on a different survival curve than patients who don’t need RVAD support Studies have not been able to successfully predict who will develop RV failure after LVAD implantation What happens in the time between when the patient goes to the OR and when they get back to the ICU is an important determinant who might develop RV failure post LVAD Surgical techniques such as implanting the HM3 in the intra-thoracic cavity, rather than intra-pericardial may help maintain LV/RV geometry to help optimize the RV post LVAD Surgical considerations for LVAD candidacy Small, hypertrophied LV: HM3 inflow cannula is small, but small hypertrophied ventricles tend towards chamber collapse during systole causing suction, needing to run slower with lower flow rates Chest size/diameter: pumps have gotten so small now, that for adults, these have become less of a consideration BMI: low BMI used to be more of a concern with the older pumps due to where they were placed, and the relative size of the pump itself, not so much now with the smaller HM 3 pumps Calcified LV apex: would increase risk of stroke, bleeding Driveline tunneling becomes a concern in the super obese population, higher risk for driveline infections (might tunnel these driveline's shorter, and to a less fatty region of the abdomen, could even tunnel out the thoracic cavity in the super obese to limit skin motion) 5. Is there a role for MCS (i.e. temporary LVAD such as Impella) in pre-habilitation of patients prior to LVAD surgery? The theory of being able to improve systemic perfusion, decongest the organs, and make the patient feel better prior to surgery makes sense, but becomes problematic due to the lack of a hard end point/time for prehabilitation which might risk delays in surgery More likely that it can lead to delay in the surgery, with less-than-optimal benefit; you don't want to prolong the wait for surgery and increase the risk for complications prior to surgery An Impella 5.5 is currently FDA approved for 2 weeks of support, not 2 months so timing is important to keep in mind It’s unlikely that you will take a patient and convert them from a malnourished, cachectic person in 2 weeks’ time 6. Is there a role for LVAD therapy in the younger patient population? Should we be thinking of LVAD up front for these patients, with the goal of transplanting down the line? Recovery may be more likely in certain populations, particularly younger females with smaller LV's; in those populations, perhaps bridge to recovery should be the focus, optimizing them on GDMT etc. The replacement of transplant, with MCS (LVAD) in young patients has become a topic of discussion, because these pumps have become better and better, with the thinking that an LVAD could bridge a patient for 10 years or so, and they could get a transplant later It is still a big unknown, but several concerns exist Patients who get LVADs might end up with complications that become contraindication to transplant down the line (stroke, sensitization etc) Patients and providers are more hesitant because of the more recent iteration for the UNOS criteria for OHT listing which no longer gives patients with an uncomplicated LVAD higher priority, and therefore they could end up waiting a longer time for a heart after undergoing LVAD References Rose EA, Gelijns AC, Moskowitz AJ, et al. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med. 2001;345(20):1435-1443. doi:10.1056/NEJMoa012175 Mehra MR, Uriel N, Naka Y, et al. A Fully Magnetically Levitated Left Ventricular Assist Device – Final Report. N Engl J Med. 2019;380(17):1618-1627. doi:10.1056/NEJMoa1900486 Mancini D, Colombo PC. Left Ventricular Assist Devices: A Rapidly Evolving Alternative to Transplant. J Am Coll Cardiol. 2015;65(23):2542-2555. doi:10.1016/j.jacc.2015.04.039 Mehra MR, Goldstein DJ, Cleveland JC, et al. Five-Year Outcomes in Patients With Fully Magnetically Levitated vs Axial-Flow Left Ventricular Assist Devices in the MOMENTUM 3 Randomized Trial. JAMA. 2022;328(12):1233-1242. doi:10.1001/jama.2022.16197 Rose EA, Moskowitz AJ, Packer M, et al. The REMATCH trial: rationale, design, and end points. Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure. Ann Thorac Surg. 1999;67(3):723-730. doi:10.1016/s0003-4975(99)00042-9 Kittleson MM, Shah P, Lala A, et al. INTERMACS profiles and outcomes of ambulatory advanced heart failure patients: A report from the REVIVAL Registry. J Heart Lung Transplant. 2020;39(1):16-26. doi:10.1016/j.healun.2019.08.017 Mehra MR, Netuka I, Uriel N, et al. Aspirin and Hemocompatibility Events With a Left Ventricular Assist Device in Advanced Heart Failure: The ARIES-HM3 Randomized Clinical Trial. JAMA. 2023;330(22):2171-2181. doi:10.1001/jama.2023.23204 Mehra MR, Nayak A, Morris AA, et al. Prediction of Survival After Implantation of a Fully Magnetically Levitated Left Ventricular Assist Device. JACC Heart Fail. 2022;10(12):948-959. doi:10.1016/j.jchf.2022.08.002 Bhardwaj A, Salas de Armas IA, Bergeron A, et al. Prehabilitation Maximizing Functional Mobility in Patients With Cardiogenic Shock Supported on Axillary Impella. ASAIO J. 2024;70(8):661-666. doi:10.1097/MAT.0000000000002170
What happens when patients become true partners in healthcare innovation? In this episode of Moving Medicine Forward, we speak with Dr. Karin Hehenberger, physician, scientist, transplant recipient, and Founder & President of Lyfebulb, about how lived experience can reshape chronic disease care.Diagnosed with type 1 diabetes as a teenager, Karin's journey through medicine, biotech, and ultimately organ transplantation inspired Lyfebulb's mission to empower patients through education, community, and innovation. We explore why patient voices must be included early in development, how patient entrepreneurs are driving real‑world solutions, and why reducing isolation is essential to better outcomes.01:00 Welcome & Guest IntroductionMeet Dr. Karin Hehenberger and the mission behind Lyfebulb.02:10 Living With Chronic Illness Karin's early diabetes diagnosis and how it shaped her path into medicine and research.05:35 When Disease Progresses Anyway Facing kidney failure and vision loss despite careful disease management.06:45 Transplant & New Perspective How kidney and pancreas transplants led to a renewed purpose.07:55 Founding Lyfebulb Why patient education, connection, and innovation are central to empowerment.10:45 Patients as Partners Moving beyond “patient‑centric” language to true collaboration.12:20 Patient‑Driven Innovation Innovation challenges and real solutions created by patients for patients.17:55 The Power of Community Reducing isolation to improve emotional health and daily disease management.22:45 Industry & Research CollaborationWhy patient insight must be integrated early—not as a checkbox.27:15 Rethinking Chronic Disease A vision for managing chronic illness without constant mental burden.31:15 Learn More How to get involved at LyfeBulb.comb
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HOUR 2- Johnny Doesn't Know, A Failed Hair Transplant and MORE full 1821 Wed, 25 Feb 2026 16:41:00 +0000 wbElrTkHkvlciqKaM8YESd5ky1XliWbT society & culture Klein/Ally Show: The Podcast society & culture HOUR 2- Johnny Doesn't Know, A Failed Hair Transplant and MORE Klein.Ally.Show on KROQ is more than just a "dynamic, irreverent morning radio show that mixes humor, pop culture, and unpredictable conversation with a heavy dose of realness." (but thanks for that quote anyway). Hosted by Klein, Ally, and a cast of weirdos (both on the team and from their audience), the show is known for its raw, offbeat style, offering a mix of sarcastic banter, candid interviews, and an unfiltered take on everything from culture to the chaos of everyday life. With a loyal, engaged fanbase and an addiction for pushing boundaries, the show delivers the perfect blend of humor and insight, all while keeping things fun, fresh, and sometimes a little bit illegal. 2024 © 2021 Audacy, Inc. Society & Culture False https://player.amperwavepodcas
I've been keeping a secret for a while... About 6 months ago, I got a hair transplant!In this episode, I talk openly about why I did this and the process that went into it. And I also talk more deeply and generally on the topic of self-esteem and self image and how the way we look affects our confidence in the world. It's a great topic to dive into, and along the way, I cover lots of useful vocabulary and phrases too. Show notes page - https://levelupenglish.school/podcast365➡️ Join the Free Mini Course - https://www.levelupenglish.school/mini⭐️ Join Level Up English - https://www.levelupenglish.schoolBecome a member and get:Podcast TranscriptsPrivate PodcastGroup ClassesPrivate CoachingAnd over 500 online lessons! Hosted on Acast. See acast.com/privacy for more information.
A baby boy has become the first to be born in the UK to a mother with a womb transplant from a deceased donor. Grace Bell, who is in her 30s, delivered her baby boy, Hugo, in December. Clare McDonnell is joined by transplant surgeon Isabel Quiroga who completed the transplant in collaboration with Professor Richard Smith and colleagues at Oxford University Hospital and Imperial College, London, and established the first uterus transplant programme in the UK.Today is the day Season 2 of the TV series We Might Regret This is released. Its creator and star, Kyla Harris, discusses how she has drawn on her experiences as a disabled person to create this funny and unflinching look at life with disability. The first results from the University of Exeter's Women in Farming health and wellbeing study are in, and they paint a concerning picture of the wellbeing of women in farming across the UK.Alev Scott's latest book, Cash Cow, investigates the global fertility industry, exploring how much the female body is being commodified, and its impact on women across the world. Who should make money from the maternal body - only the women themselves, anyone or no one? Going undercover, she explores the breast milk black market, the trade in harvesting eggs, and the women who are surrogates for others. Presenter: Clare McDonnell Producer: Kirsty Starkey
Rich — a leukemia survivor, nurse practitioner, and longtime oncology clinician — to talk about what it's really like to survive cancer, rebuild your life after treatment, and live with long-term side effects.Rich was diagnosed with leukemia at age 28, underwent an allogeneic stem cell transplant at Dana-Farber / Brigham and Women's, and is now a 29-year survivor. His experience as both a patient and provider offers a rare, honest look at cancer survivorship, prostate cancer side effects, sexual health, mental health, and post-traumatic growth.In this conversation, we cover:What it's like to be told you have leukemia in your 20sStem cell transplant and long-term survivalTurning cancer into purpose and becoming an oncology NPCommon prostate cancer side effects (urination, bowel changes, erectile dysfunction)How doctors actually manage these symptomsSexual health after cancer treatmentMental health, grief, and post-traumatic growthHow to rebuild your life after active treatmentThis episode is for patients, survivors, caregivers, and anyone navigating life after a cancer diagnosis.
Al's on today's proper jaw-dropper: London doctors announce a UK first — a baby born after a womb transplant from a deceased donor. Then it's back to the paperwork side of the future as the government drags Netflix, Prime Video and the rest into tougher Ofcom-style rules. After the break, Uber tries to become the backstage crew for robotaxis everywhere, scientists reveal a new way to see DNA's 3D structure, Fallout 4 goes portable on Switch 2, and Firefox does something radical: it gives you an AI off switch. More on all of it at standard.co.uk — and follow Tech and Science Daily from The Standard for your weekday briefing. Hosted on Acast. See acast.com/privacy for more information.
It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: big updates for stem cell and islet transplants, new pen option for Zepbound, an implantable insulin pump moves forward and more! Announcing Community Commericals! Learn how to get your message on the show here. Learn more about studies and research at Thrivable here Please visit our Sponsors & Partners - they help make the show possible! Omnipod - Simplify Life All about Dexcom T1D Screening info All about VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com Episode transcription with links: Welcome! I'm your host Stacey Simms and this is an In The News episode.. where we bringing you the top diabetes stories and headlines happening now. A reminder that you can find the sources and links and a transcript and more info for every story mentioned here in the show notes. Quick reminder: I'm just back from MNO DC and I'm exhausted. But it's the best kind of tired. We had an incredible time – hope you can join us in Nashville. With a reminder that we have our first Club 1921 in Nashville – that's our educational dinner series for HCPs and patient leaders. All the info is over at diabetes-connections.com events/ Okay.. our top story this week: XX An "immune system reset" eliminated Type 1, diabetes in mice in a study conducted at Stanford Medicine without immune suppressant medications. This was a combined transplant of blood stem cells and insulin-producing pancreatic islet cells from a donor whose immune profile did not match the recipient. The dual transplant approach both restored insulin production and retrained the immune system. For the full six months of the experiment, the animals did not need insulin injections or immune suppressive medications. Challenges remain using this approach to treat Type 1 diabetes. Pancreatic islets can be obtained only after death of the donor, and the blood stem cells must come from the same person as the islets. It is also unclear whether the number of islet cells typically isolated from one donor would be enough to reverse established Type 1 diabetes. But the researchers are working on solutions, which could include generating large numbers of islet cells in the laboratory from pluripotent human stem cells, or finding ways to increase the function and survival of transplanted donor islet cells. https://scitechdaily.com/stanford-scientists-cure-type-1-diabetes-in-mice-without-insulin-or-immune-suppression/ XX An electronic implant interlaced with islet cells is being looked at to treat type 1. Researchers at the University of Pennsylvania School of Medicine worked with engineers at Harvard University to combine stem-cell biology with soft electronics. They inserted an ultrathin, flexible mesh of conductive wires — thinner than a human hair — into developing pancreatic tissue. As the cells assembled into clusters, the mesh became woven through them. The electronics can record the faint electrical signals produced by the cells that control insulin release. They can also deliver small pulses of electricity back to the cells. After several days, the cells began to behave more like mature islets. Their internal signalling shifted, neighbouring cells started working in concert and insulin release became stronger and better timed. Very early on here – and the transplanted cells still need to be protected from being attacked by the immune system. https://www.thetimes.com/uk/science/article/first-cyborg-pancreas-implants-type-1-diabetes-nxkv8r0fp?gaa_at=eafs&gaa_n=AWEtsqeJYYUF9TMR-GgGUG92hPyog-ISeiqGIgdyaaIKKcpvhtoftGiUaaOtQeG0NWI%3D&gaa_ts=699c50d4&gaa_sig=w-PQ0ArosZSznYDSWEzt8aQg4WC0FF5ZFRt9NedO5sSTL2FyWzupH8eSG7RCy2S8TQnlHOeKCudANWm1MNI59w%3D%3D XX Katie Beth (hand) Eledon trial – aaron kowalski post linkedin. Last fall we told you about promising results from Eledon's drug to prevent islet transplantation rejection in type 1 diabetes. The first six patients no longer had to inject or infuse insulin.. the trials continue and this month one of the patients – Katie Beth Hand – began posting about her experiences one month in, on social media, she says she's off basal insulin already and in range 99 percent of the time. She is also encouraging people to learn more about support the islet act https://lnkd.in/e8pQ7_Y7 XX This is a bill introduced last November which would change the wording on pancreatic cell transplants. The problem is that islets are classified as drugs rather than organs, making transplantations difficult for medical teams and centers to preform due to accessibility. Insurance companies are also less likely to provide reimbursements for treatment, which can cost hundreds of thousands of dollars. The official Journal of The Transplantation Society estimates the cost at about $140,000. The bill went to the senate committee of Health, Education, Labor, and Pensions in early November. No other action has been taken since then. https://www.wtoc.com/2026/02/19/bluffton-family-advocates-islet-act-help-diabetic-son/ XX Big change for the obesity drug Zepbound – now available in the multi dose KwikPen. This is a month's worth of doses in a single pen.. and it's multi dose – you can adjust it. Cash-paying patients can get the multi-dose device, called KwikPen, on the company's direct-to-consumer website, LillyDirect. Prices start at $299 per month for the lowest dose level. Until now, you could only get zepbound in a single dose auto injector or a sing dose vial. In a release, Lilly said the Food and Drug Administration approved a label expansion for Zepbound to include the multi-dose device. The KwikPen is already used for other drugs, such as Lilly's popular diabetes medication, Mounjaro – which is the same medication as zepbound, they're both tirzepitide. https://www.cnbc.com/2026/02/23/eli-lilly-launches-zepbound-obesity-drug-pen-one-month-doses.html XX For years, researchers have observed that people who live at high elevations, tend to develop diabetes less often than those at sea level. Although the trend was well documented, the biological explanation behind it was unclear. Scientists now say they have identified the reason. Their research shows that in low oxygen environments, red blood cells begin absorbing large amounts of glucose from the bloodstream. Their work showed that when oxygen is limited, red blood cells use glucose to generate a molecule that helps release oxygen to tissues. This process becomes especially important when oxygen is in short supply. The researchers also found that the metabolic benefits of prolonged hypoxia lasted for weeks to months after mice were returned to normal oxygen levels. They then evaluated HypoxyStat, a drug recently developed in Jain's lab that mimics low oxygen exposure. HypoxyStat is taken as a pill and works by causing hemoglobin in red blood cells to bind oxygen more tightly, limiting the amount delivered to tissues. In mouse models of diabetes, the medication completely reversed high blood sugar and outperformed existing treatments. https://www.sciencedaily.com/releases/2026/02/260221060952.htm XX Watching this one closely – Portal Diabetes gets FDA breakthrough device designation for its implantable insulin pump system. This is a system that includes not just a device that's implanted into the abdomen, but also a new, temperature stable insulin. It will work with – quote – "modern" CGM technology with a fully closed loop - and aims to deliver a functional cure for type 1. While reports say Portal's system is the first in the US – there was an implantable pump developed and used by about 500 people worldwide, including about 100 in the US – by MiniMed. Medtronic bought the company and in 2007 they stopped that program. Portal Diabetes expects to begin clinical trials on its combination system around the fourth quarter of 2027. https://www.drugdeliverybusiness.com/portal-diabetes-fda-breakthrough-implantable-insulin-pump/ XX Sequel Med Tech and Senseonics (NYSE:SENS) today announced the full U.S. launch of their CGM and insulin pump integration. That's the eversense cgm and twist pump. Sequel said its full launch with Eversense 365 makes twiist available with two compatible CGMs. twiist also pairs with the Abbott FreeStyle Libre 3 Plus sensor. Eversense 365, an implantable system, rests under the skin for the duration of a year. Users can change its external, silicone-based adhesive daily with almost no skin reactions. https://www.drugdeliverybusiness.com/sequel-senseonics-full-launch-twiist-eversense/ XX Right back with a Dexcom update, and a look at which type of diet reduces insulin use overall.. right after this: -- Back to the news.. Dexcom is watching for expanded Medicare coverage of its continuous glucose monitors to people with Type 2 diabetes who don't take insulin. CEO Jake Leach told investors on Thursday that the company has been "sitting here waiting for a coverage decision" from the Centers for Medicare and Medicaid Services Dexcom started to see commercial coverage unlock for Type 2, non-insulin users toward the end of last year, Leach said. He expects broader Medicare coverage for that group would allow nearly 12 million people to access CGMs. In the meantime, the American Diabetes Association updated its guidelines last year to recommend clinicians consider using CGMs for Type 2 diabetes when patients are taking glucose-lowering medications other than insulin. Leach said that real world data the company has been generating supports that decision, and that Dexcom has launched a registry for non-insulin users. https://www.medtechdive.com/news/dexcom-seeks-expanded-medicare-coverage-of-cgms-for-type-2-diabetes/812223/ XX Medtronic's separation of MiniMed is not yet complete.. but continues to move forward. The company has submitted their next pump – MiniMed Flex – to the FDA. This is a pump smaller than the 780G but uses the same reservoirs and infusion sets. It will also work with both the Simplera Sync and Instinct sensors. Medtronic also began a U.S. pivotal study for Vivera, its third-generation algorithm for automated insulin delivery. It also remains set to submit its MiniMed Fit patch pump system to the FDA by the coming fall. https://www.drugdeliverybusiness.com/medtronic-submits-minimed-flex-fda-q3/ XX A study modelling how genes may influence a child's body mass index over time has found that BMI at age 10 and overall growth rate between ages one and 18 might be important factors, as the two are more likely linked to diabetes, high cholesterol, and heart disease in later life. Nearly 66,000 BMI measurements from around 6,300 children and adolescents aged one to 18 were analysed to understand the role of genes. "Future research is needed to help identify the most effective ages to prevent obesity or poor growth for long-term benefit." https://www.ndtv.com/health/bmi-at-age-10-growth-rate-up-to-age-18-are-important-factors-for-diabetes-heart-disease-study-11125146 XX A low-fat vegan diet—without cutting calories or carbs—may help people with type 1 diabetes significantly reduce how much insulin they need. In a new analysis published in BMC Nutrition, participants following the plant-based plan lowered their daily insulin use by 28%, while those on a portion-controlled diet saw no meaningful change. Researchers say the reduced insulin requirement likely reflects improved insulin sensitivity. The original 2024 study reported additional benefits from the vegan diet. Participants lost an average of 11 pounds and showed improvements in insulin sensitivity and glycemic control. Cholesterol levels and kidney function also improved among those following the plant-based plan. https://www.sciencedaily.com/releases/2026/02/260212234212.htm XX Interesting little tidbit from the Winter Olympic Games.. the World Anti-Doping Agency (WADA) was monitoring GLP drug use. An advisory group that makes recommendations about WADA's list of prohibited substances discussed the status of GLP-1 medications, and added semaglutide (Ozempic, Wegovy, Rybelsus) and tirzepatide (Mounjaro, Zepbound) to its monitoring program That means patterns of use of these drugs will be tracked both in and out of competition. The finding will be used to make recommendations about whether GLP-1 agonists should be added to the prohibited list, the spokesperson explained. While GLP-1 drug use is not currently prohibited, that could change before the next Summer Olympic Games in Los Angeles in 2028, he noted. https://www.medpagetoday.com/popmedicine/cultureclinic/119770 XX That's it for in the news!
Mary Roach describes the process of tissue donation, focusing on corneal transplants and the meticulous, respectful recovery of bone and skin to benefit many patients awaiting procedures. 4
CHAPTERS 00:00 - 09:20. - Flight over/initial thoughts 09:21 - 16:25 - Night one dinner/ WSD outing 16:26 - 28:27 - Culture shock 28:28 - 37:06 - Ben Mintz 37:07 - 49:43 - The hair transplant process 49:44 - 55:48 - John's injury abroad 55:49 - 1:11:08 - Final thoughts DESCRIPTION Pat sits down with John Feitelberg to recap his trip to Turkey for "Baldstool Season 2" with The Wonton Don and company, the culture shock he experienced, and what it's really like getting a hair transplant abroad with coworkers. Like and comment on this video to help us out! Love you all hehe SUPPORT OUR SPONSORS MeUndies Get 20% off your first order, plus free shipping at https://MeUndies.com/pat Wayfair Head to https://Wayfair.com right now to shop all things home.You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/outandabout
For the next few weeks, the guys will be re-airing some of their favourite episodes from our archives.Today, Ali and Asif review the new documentary about Louis CK, ‘Sorry / Not Sorry' (1:53). They start off by discussing Louis CK's background, his blockbuster success as a stand up comedian and how he changed the financial model of stand up comedy specials. Then then discuss his sexual impropriety as outlined in the New York Times as well as in the documentary. The guys go over what they perceive as his lack of an apology as well as how CK was definitely not “canceled”. Louis CK does suffer from male pattern baldness (androgenic alopecia), so in the second half of the episode, the guys discuss hair transplants (28:36) (N.B. Louis CK has never stated that he has had a hair transplant). Asif starts off by discussing how common baldness is and what causes it in most men. He then goes over other treatments for baldness like ‘Rogaine' and ‘Propecia'. He then goes over what hair transplants entail, the procedure, the costs, and the outcomes. The opinions expressed are those of the hosts, and do not reflect those of any other organizations. This podcast and website represents the opinions of the hosts. The content here should not be taken as medical advice. The content here is for entertainment and informational purposes only, and because each person is so unique, please consult your healthcare professional for any medical questions. Music courtesy of Wataboi and 8er41 from PixabayContact us at doctorvcomedian@gmail.comFollow us on Social media:Twitter: @doctorvcomedianInstagram: doctorvcomedianShow Notes: Louis C.K. Is Accused by 5 Women of Sexual Misconduct: https://www.nytimes.com/2017/11/09/arts/television/louis-ck-sexual-misconduct.htmlThe sexual harassment allegations against Louis C.K., explained: https://www.vox.com/culture/2017/11/9/16629400/louis-ck-allegations-masturbationHey, Comedy: Don't Let Them Back In: https://www.pastemagazine.com/comedy/the-industry/sexual-misconduct-in-comedyOpinion: This film is chilling reminder of how ‘not sorry' Louis C.K. is: https://www.cnn.com/2024/07/12/opinions/sorry-not-sorry-louis-ck-misconduct-women-comedy-stewart/index.htmlFemale Comics Sound Off on Kevin Hart, Louis C.K. and Comedy in the Age of Trump: https://www.hollywoodreporter.com/lifestyle/lifestyle-news/female-comics-kevin-hart-louis-ck-comedy-age-trump-1201578/Comedian Louis C.K. Talks Hair Loss in Online Chat: https://www.hairlossspecialists.com/articles/louis-ck-balding-talk/130/Hair Transplantation: https://emedicine.medscape.com/article/839753-overviewWhat Is the Norwood Scale? https://www.healthline.com/health/norwood-scale#stagesHair Transplants: What to Expect: https://www.webmd.com/skin-problems-and-treatments/hair-loss/hair-transplants Hosted on Acast. See acast.com/privacy for more information.
For much of our lives, performance is measured in speed, strength, and output. As we get older, the equation changes. On this episode of The Dr. Hyman Show, I sit down with Sir David Beckham and Dr. Dawn Mussallem to explore what elite sport, stage IV cancer, and heart transplantation can teach us about prevention—and what it really takes to sustain health over time. Watch the full conversation on YouTube or listen wherever you get your podcasts. Together, we explore: • Why your health trajectory is more changeable than you've been taught—especially after 40 • How sleep, stress, and metabolic health quietly shape your long-term disease risk • Which daily habits give you the biggest return on investment over decades • How to build resilience now so your body supports you later The real measure of health isn't what you can achieve in your 20s or 30s. It's the resilience you build so your body supports you for decades to come. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Maui Nui, Made In Cookware, Timeline, Seed, Sunlighten and BON CHARGE. Learn more about the health benefits of venison and how to get yours, head over to mauinuivenison.com/hyman. Head to madeincookware.com and use the code DRHYMAN for 10% off your order. Receive 35% off a subscription at timeline.com/drhyman. Go to seed.com/hyman and use code 20HYMAN to get 20% off your first month. Visit sunlighten.com and use code HYMAN to save up to $1400. Upgrade your routine. Head to boncharge.com/hyman and use code HYMAN for 15% off. (0:00) Sir David Beckham and Dr. Dawn Mussallem on Health and Recovery (1:25) Defining Health and Wellness (2:33) David Beckham's Diet and Athlete Nutrition Evolution (8:23) Health Maintenance Post-Retirement and Turning 50 (14:50) Dr. Dawn Mussallem's Health Journey and Heart Transplant Experience (25:05) Lifestyle Changes, Sleep, and Nutrient Deficiencies (29:55) David Beckham's Daily Routine and Connection with Nature (41:21) Dawn Mussallem's Daily Health Practices and Mayo Clinic Research (44:54) Essential Habits for Sustained Health (47:17) Dietary Choices and Anti-Inflammatory Foods (52:00) Recovery Tools and Health Priorities in Later Life (56:10) Closing Remarks
Every other week I'm republishing one of my most popular or impactful episodes from my backlog of over 450 episodes. This week I'm highlighting Episode 279, which is all about bone marrow transplants. ___________________ *For an excellent summary of the neutropenic diet, check out this resource from Memorial Sloan Kettering Cancer Center. * Interested in saving a life? Register with Be The Match. Full Transcript - Read the article and view references FREE CLASS - If all you've heard are nursing school horror stories, then you need this class! Join me in this on-demand session where I dispel all those nursing school myths and show you that YES...you can thrive in nursing school without it taking over your life! LATTE Method Template - Download the free LATTE Method Template so you can streamline how you study and focus on what a nurse needs to know. Med Surg Solution - Are you looking for a more effective way to learn Med Surg? Enroll in Med Surg Solution and get lessons on 57 key topics and out-of-this-world study guides.
Face transplant patient Robert Chelsea and writer Fay Bound Alberti talk through the promise – and darker side – of this pioneering surgery. Help support our independent journalism at theguardian.com/infocus
This month on Episode 81 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the January 30th and February 13th issue of Circulation Research. This Episode also features a discussion with Dr Claudia Goettsch and Nicolas Hense, about their study, 1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification. Article highlights: Hu, et al. CircZBTB44 Inhibits Calcific Aortic Valve Disease Schemelei, et al. Olfr2 Aggravates AAA Formation Zhang, et al. Neratinib Protects Against Atherosclerosis Sun, et al. CD34+ Cells in Transplants
On this Make A Difference Minute, Coleman Drew talks about the timeline surrounding his upcoming transplant. Diagnosed with cystic fibrosis at just two years old, Coleman has spent his life managing daily treatments and health challenges. Now, as transplant becomes the next step in his journey, he shares what the process looks like, what happens next, and how he and his family are preparing. This is a powerful glimpse into the reality behind the word “transplant.” If you would like to support Coleman and his family with transplant-related expenses, visit: cota.org/cotaforcolemansfight Sponsor: Singing River Dentistry SingingRiverDentistry.com
What does abundance look like when you work with people in the most fragile moments of their lives?In this deeply moving episode, Amy Sylvis sits down with her former cystic fibrosis physician, Dr. Kamyar Afshar, now Medical Director of the Lung Transplant Program at UC San Diego. Together, they explore what it means to practice medicine with dignity, compassion, and cultural awareness, and how lived experience shapes leadership.Dr. Afshar shares his family's immigration story from Iran, the values of service instilled by his parents, and how those experiences shaped his approach to medicine. He opens up about leading during COVID, navigating misinformation with grace, mentoring the next generation of physicians, and raising children with intentional values. This conversation is about more than medicine. It's about connection. Courage. Asking for help. And creating abundance through service.UC San Diego Health – Lung Transplant Program
Recorded live at a special Heart Month Event at Rapid City Hospital, Luis Hernandez, M.D., FACC, Cardiologist atthe Heart and Vascular Institute and Medical Director of the Advanced Heart Failure program speaks with Renea, a patient who received a heart and kidney transplant just under a year ago. Renee recounts what led up to Dr. Hernandez's recommendation for a heart transplant and what happened between that time and when she underwent the procedure. She also explains how her family helped to convince her to undergo the transplant and what she experienced during recovery.Don't miss this unique opportunity to hear from a patient who has experienced a life-saving procedure and is grateful for the results. Hosted on Acast. See acast.com/privacy for more information.
On this episode of Walk and Roll Live – Disability Stories, Doug Vincent sits down with Ty Gipson, entrepreneur, motivational speaker, and resilience advocate whose life has been shaped by extraordinary medical and personal challenges. Diagnosed with Type 1 juvenile diabetes at a young age, Ty's journey includes multiple life-saving organ transplants, years of uncertainty, and moments where giving up might have seemed easier than pushing forward. Instead, Ty adopted what he calls a “No Options” mindset — a belief that when quitting isn't an option, purpose takes over. In this powerful conversation, Ty shares how his health challenges shaped his outlook on life, leadership, and service, how entrepreneurship gave him a sense of control and creativity, and how gratitude, faith, and community helped him thrive beyond survival. Together, Doug and Ty explore disability, chronic illness, resilience, and the power of choosing hope when the path forward is unclear. This episode is a must-watch for anyone navigating disability, chronic illness, major life transitions, or searching for inspiration to keep moving forward — no matter the odds. Walk and Roll Live
Dr. Dawn Mussallem is a Mayo Clinic oncologist who survived stage 4 cancer at 26, heart failure, and a heart transplant—then became the first person to run a marathon within a year of receiving a new heart. This conversation explores the integrative approach to cancer treatment, why exercise might be as powerful as chemotherapy, the self-flagellation patients feel despite doing everything right, and the profound role of mindset in survival. Typically, my guests fall into two buckets—incredible story or incredible expertise. I don't know that I've ever had a guest who inhabits both worlds the way Dawn does. Her story is super inspirational, and the information is equally impactful. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today's Sponsors: Noble Mobile: The first phone carrier that pays you to use your phone less. Try it for just $10 with code RICHROLL
**Special note to our listeners** Love the show? Help us keep the conversation going!Become a paid subscriber through our Substack.Your contributions help us continue to make contenton issues related to the Asian-American, immigrant, modern parent experience.THANK YOU to our super awesome listeners who have already signed up!---------------------------------------We welcome Daniel Tam-Claiborne back for a second recording because as Susan would say, there was just too much juice to squeeze in just one episode :) While we talked about his experience growing up as a Chinese-Jewish biracial kid in New York City in the last recording, we fast forward in this one to his experience of becoming a dad. Daniel experienced significant symptoms of postpartum depression after his daughter arrived and he talks us through that often hidden experience that many dads go through after they become parents. He started speaking to his quarter- Chinese daughter in Mandarin as he was coming out of the worst of his postpartum depression and we discuss how he and his wife arrived at the decision to commit to a bilingual upbringing for their child who doesn't easily "read" as Chinese or Chinese American.If you'd like to learn more about Daniel Tam-Claiborne and his work, check out:- His debut novel Transplants which was a 2023 PEN America Literary Award Finalist- Website at www.travelbreedscontent.com
Une femme au Royaume-Uni donne naissance à une fille après avoir reçu une greffe d'utérus de sa sœur, une première médicale dans le pays. Traduction:A woman in the UK gives birth to a girl after receiving a uterus transplant from her sister, a medical first in the country. Hosted on Acast. See acast.com/privacy for more information.
Une femme au Royaume-Uni donne naissance à une fille après avoir reçu une greffe d'utérus de sa sœur, une première médicale dans le pays. Traduction:A woman in the UK gives birth to a girl after receiving a uterus transplant from her sister, a medical first in the country. Hosted on Acast. See acast.com/privacy for more information.
Walking the path God calls us to can feel heavy, uncertain, and overwhelming—but we are never walking alone. When we trust Him, God goes before us, leveling the path ahead and sustaining us for the journey, even when the road feels impossible. In this special episode, Chip and Wendy Frazier, who shared their story at our live gathering in Tupelo, Mississippi, invite us into their journey of faith as Chip awaited a life-saving heart transplant while battling hypertrophic cardiomyopathy. Through seasons of depression, fear, surrender, and steadfast hope, they witnessed God preparing the way, meeting them in the waiting, and answering prayers in unexpected and loving ways. VERSE OF THE WEEK: "Teach me how to live, oh Lord, lead me along a level path." Psalm 27:11 CHALLENGE OF THE WEEK: Spend some time this week counting God's blessings to you and allow the assurance of those blessings in your past to give you strength for the future. _________________________________________________________________ Click HERE to access Spotify and listen to any of our couples who have shared for the StoryTellers Live podcast in the past! Not a Spotify-er? Click on a particular story below: Ep. 17- Sarah Beth & Clay Hagler: "A Second Chance- A Marriage Story" Ep. 18- Amanda & CJ Blount: "Freedom As One" Ep. 54- Rachel & Brian Stockard: "Redemption After Addiction" Ep. 98- Andrea & Greg: "Broken and Restored" Ep. 144- Cassie & Nic Brown: "A Good Day for a Miracle" (listener favorite!) Ep. 154- Keisha & Ricardo Reeves: "Redemptive Love" Ep. 230- Susannah & David Ash: "Wandering Canvas" Ep. 259- Shannon & Aaron Eissler: "Life Change in Community- A Marriage Story" Ep. 309- Katie & JT Thornbury: "Seek and You Will Find-: A Marriage and Salvation Story" Download a phone background of the weekly verse HERE! Give to StoryTellers Live in honor of Wendy & Chip and any of our past storytellers! Join us "In the Room" on Patreon to access new stories straight from our live gatherings around the country! Click here for further details on our Stories of Hope luncheon on March 11th in Birmingham! Register for our Finding God in the Details: A Guide to Discerning His Voice and Discovering Your Story workshop being offered online on February 18th from 9:30-12:00. Shop for our When God Shows Up Bible Study series~ Stories of Hope, Stories of Freedom, Stories of Faith Are you interested in one-on-one coaching with our very own Robyn Kown!? Click HERE! Check out all of our live speaking engagement opportunities on our website. Sign up to receive StoryTellers Live's weekly newsletter for updates and details on our live gatherings.
CONNECT WITH JULIE MATTSON:• Website: https://pushinguplilies.com• Facebook: https://www.facebook.com/pushinguplilies
Trending with Timmerie - Catholic Principals applied to today's experiences.
On this episode of Trending with Timmerie: Episode Guide A woman was euthanized, and her face transplanted to another woman in Spain (0:46) What does the Bible say about friendship? (22:15) Patriots quarterback on getting married super young (41:15) Resources mentioned: A woman was euthanized, and her Face Transplanted to another woman in Spain https://www.nationalreview.com/corner/woman-euthanized-and-her-face-transplanted-in-spain/ Benedict XVI, Address to participants at an international congress on organ donation (Nov. 7, 2008) https://www.vatican.va/content/benedict-xvi/en/speeches/2008/november/documents/hf_ben-xvi_spe_20081107_acdlife.html
Abdominal organ procurement is a high-stakes operation that blends anatomy, speed, and coordinated teamwork. In this Behind the Knife episode, the UNMC transplant team walks through the practical “how-to” of deceased donor abdominal recovery—covering OR roles and logistics, key anatomic maneuvers, cannulation/flush troubleshooting, and the workflow differences that matter most between donation after brain death (DBD) and donation after circulatory death (DCD).HostsMadeline Cloonan, MD PhD – General Surgery Resident, University of Nebraska Medical Center (@maddie_cloonan) Evelyn Waugh, MD – Transplant Surgery Fellow, University of Nebraska Medical Center Jacqueline Dauch, MD – Abdominal Transplant Surgeon, University of Nebraska Medical Center Alex Maskin, MD – Kidney & Pancreas Transplant Surgeon, University of Nebraska Medical CenterLearning Objectives Compare DBD vs DCD donor workflow and define total vs functional warm ischemia. Identify key OR roles and the ethical/legal separation of death declaration from procurement teams. Outline the core steps of abdominal procurement, including exposure, cannulation, cross-clamp, and organ removal sequence. Apply a practical troubleshooting approach when flush flow is inadequate References Englesbe MJ, Mulholland MW. Operative Techniques in Transplantation Surgery. Philadelphia, PA: Wolters Kluwer; 2018. Tullius SG, Rabb H. Improving the supply and quality of deceased-donor organs for transplantation. N Engl J Med. 2018;378(20):1924–1933. doi:10.1056/NEJMra1708700. https://pubmed.ncbi.nlm.nih.gov/29768153/ Croome KP, Barbas AS, Whitson B, et al. American Society of Transplant Surgeons recommendations on best practices in donation after circulatory death organ procurement. Am J Transplant. 2023;23(2):171–179. doi:10.1016/j.ajt.2022.10.009. https://pubmed.ncbi.nlm.nih.gov/36695685/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium:General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US
Turkey has become a top destination for the booming business of hair transplants. But why are so many men opting for the procedure? We talk to John Paul Brammer, a writer and artist based in Brooklyn about his own experience with hair transplants. Plus, Glen Jankowski, an adjunct lecturer and researcher in the School of Psychology at University College Dublin, and the author of a forthcoming book, Branding Baldness, about how our perception of baldness changed over the years.
Justin Bieber Biography Flash a weekly Biography.Hey there, fabulous listeners, its your girl Roxie Rush here, your AI gossip whirlwind powered by the smartest tech out there whipping up fresh scoops faster than you can say red carpet ready and trust me, thats a good thing because I never sleep on the tea. Justin Bieber just owned the 2026 Grammys on February 1st darling, strutting onstage in nothing but satin boxers from his Skylrk line and socks, cradling a purple guitar for a raw stripped-down Yukon performance that had everyone gasping. Elle reports producer Ben Winston spilling on the Rolling Stone Music Now podcast that JB didnt even pick his outfit till he hit the stage pure vibe check no script and it broke the internet with that emotional punch. Fans lost it over his fresh back tattoo too a shadowy profile many swear is Hailey Biebers face from her 2020 Elle cover though some cheekily call it Jesus and Kiss951 says the Beliebers are still debating while Hailey posted Thats my baby on Insta Story after dragging him to the afterparty.Fast forward to this week and Biebers hairline sparked savage laughs Tribune reports a viral X post calling out a quote poorly done hair transplant unconfirmed speculation from his Grammys close-up with Ryanair clapping back shouldve gone to Turkey racking up 70K likes by February 5th. No word from JB hes stayed mum letting the buzz simmer.Biz wise hes stacking that 300 million net worth per Celebrity Net Worth fueled by his 200 million 2022 catalog sale to Hipgnosis plus Skylrk hype and a massive reported 10 million plus Coachella 2026 headline gig his first US show since 22 per Cosmo though hes guarding his mental space no full tour yet. Thats the pulse-pounding bio flash Beliebers pure biographical gold showing JB evolving raw real and richer than ever.Thanks for tuning in lovelies subscribe to never miss an update on Justin Bieber and search Biography Flash for more great biographies. MuahAnd that is it for today. Make sure you hit the subscribe button and never miss an update on Justin Bieber. Thanks for listening. This has been a Quiet Please production."Get the best deals https://amzn.to/42YoQGIThis content was created in partnership and with the help of Artificial Intelligence AI
In this episode:00:42 External, artificial-lung system keeps patient alive for transplantNature: 48 hours without lungs: artificial organ kept man alive until transplant06:22 How lung cancer in mice hijacks neurons to outwit the immune systemNature: How tumours trick the brain into shutting down cancer-fighting cellsSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.
Program notes:0:50 Rapid recovery of hearts for transplant after circulatory death1:50 Total ischemic time longer than 4 hours2:50 Typically reanimate3:50 Expanded to donors 40 years of age4:55 Do women with PCOS have increased risk for arrhythmia5:55 Incidence arrhythmia in these women increased risk6:50 An LLM to streamline transitions from primary to secondary care7:50 Used alone, with staff support, or control8:51 Decreased amount of time in the consult9:52 Things that accumulate data will be embraced10:12 Treating gout to prevent CVD11:12 Lowered in about a fourth of patients12:36 End
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CardioNerds (Dr. Shazli Khan, Dr. Jenna Skowronski, and Dr. Shiva Patlolla) discuss the management of patients post‑heart transplantation with Dr. Shelley Hall from Baylor University Medical Center and Dr. MaryJane Farr from UTSW. In this comprehensive review, we cover the physiology of the transplanted heart, immunosuppression strategies, rejection surveillance, and long-term complications including cardiac allograft vasculopathy (CAV) and malignancy. Audio editing for this episode was performed by CardioNerds intern Dr. Bhavya Shah. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Heart Success Series PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls The Denervated Heart: The donor heart is surgically severed from the autonomic nervous system, leading to a higher resting heart rate (90-110 bpm) due to loss of vagal tone. Because the heart relies on circulating catecholamines rather than neural input to increase heart rate, patients experience a delayed chronotropic response to exercise and stress. Importantly, because afferent pain fibers are severed, ischemia is often painless. Rejection Surveillance: Rejection is classified into Acute Cellular Rejection (ACR), which is T-cell mediated, and Antibody-Mediated Rejection (AMR), which is B-cell mediated. While endomyocardial biopsy remains the gold standard for diagnosis, non-invasive surveillance using gene-expression profiling (e.g., AlloMap) and donor-derived cell-free DNA (dd-cfDNA) is increasingly utilized to reduce the burden of invasive procedures. The Infection Timeline: The risk of infection follows a predictable timeline based on the intensity of immunosuppression. The first month is dominated by nosocomial infections. Months one through six are the peak for opportunistic infections (Cytomegalovirus, Pneumocystis, Toxoplasmosis) requiring prophylaxis. After six months, patients are primarily at risk for community-acquired pathogens, though late viral reactivation can occur. Cardiac Allograft Vasculopathy (CAV): Unlike native coronary artery disease, CAV presents as diffuse, concentric intimal thickening that affects the entire length of the vessel, including the microvasculature. Due to denervation, patients rarely present with angina; instead, CAV manifests as unexplained heart failure, fatigue, or sudden cardiac death. Malignancy Risk: Long-term immunosuppression significantly increases the risk of malignancy. Skin cancers (squamous and basal cell) are the most common, followed by Post-Transplant Lymphoproliferative Disorder (PTLD), which is often driven by Epstein-Barr Virus (EBV) reactivation. Notes Notes: Notes drafted by Dr. Patlolla 1. What are the unique physiological features of the transplanted heart? The hallmark of the transplanted heart is denervation. Because the autonomic nerve fibers are severed during harvest, the heart loses parasympathetic or vagal tone, resulting in a resting tachycardia (typically 90-110 bpm). The heart also loses the ability to mount a reflex tachycardia; thus, the heart rate response to exercise or hypovolemia relies on circulating catecholamines, which results in a slower “warm-up” and “cool-down” period during exertion. 2. What are the pillars of maintenance immunosuppression regimen? The triple drug maintenance regimen typically consists of: Calcineurin Inhibitor (CNI): Tacrolimus is preferred over cyclosporine. Key side effects include nephrotoxicity, hypertension, tremor, hyperkalemia, and hypomagnesemia. Antimetabolite: Mycophenolate mofetil (MMF) inhibits lymphocyte proliferation. Key side effects include leukopenia and GI distress. Corticosteroids: Prednisone is used for maintenance but is often weaned to low doses or discontinued after the first year to mitigate metabolic side effects (diabetes, osteoporosis, weight gain). 3. How is rejection classified and diagnosed? Rejection is the immune system’s response to the foreign graft and is categorized by the arm of the immune system involved: Acute Cellular Rejection (ACR): Mediated by T-lymphocytes infiltrating the myocardium. It is graded from 1R (mild) to 3R (severe) based on the extent of infiltration and myocyte damage. Antibody-Mediated Rejection (AMR): Mediated by B-cells producing donor-specific antibodies (DSAs) that attack the graft endothelium. It is diagnosed via histology (capillary swelling) and immunofluorescence (C4d staining). Diagnosis has historically relied on endomyocardial biopsy. However, non-invasive tools are gaining traction. Gene Expression Profiling (GEP) assesses the expression of genes associated with immune activation to rule out rejection in low-risk patients. Donor-Derived Cell-Free DNA (dd-cfDNA) measures the fraction of donor DNA in the recipient’s blood. Elevated levels suggest graft injury which can occur in both ACR and AMR. 4. What is the timeline of infectious risk and how does it guide prophylaxis? Infectious risk correlates with the net state of immunosuppression. < 1 Month (Nosocomial): Risks include surgical site infections, catheter-associated infections, and aspiration pneumonia. 1 – 6 Months (Opportunistic): This is the period of peak immunosuppression. Patients are at risk for PJP, CMV, Toxoplasma, and fungal infections. Prophylaxis typically includes Trimethoprim-Sulfamethoxazole (for PJP/Toxo) and Valganciclovir (for CMV, dependent on donor/recipient serostatus). > 6 Months (Community-Acquired): As immunosuppression is weaned, the risk profile shifts toward community-acquired respiratory viruses (Influenza, RSV) and pneumonias. However, patients with recurrent rejection requiring boosted immunosuppression remain at risk for opportunistic pathogens. 5. How does Cardiac Allograft Vasculopathy (CAV) differ from native CAD? CAV is the leading cause of late graft failure. Unlike the focal, eccentric plaques seen in native atherosclerosis, CAV is an immunologically driven process causing diffuse, concentric intimal hyperplasia. It affects both epicardial vessels and the microvasculature. Because of this diffuse nature, percutaneous coronary intervention (PCI) is often technically difficult and provides only temporary palliation. The only definitive treatment for severe CAV is re-transplantation. Surveillance is critical and is typically performed via annual coronary angiography, often using intravascular ultrasound (IVUS) to detect early intimal thickening before it is visible on the angiogram. References Costanzo MR, Dipchand A, Starling R, et al. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010;29(8):914-956. doi:10.1016/j.healun.2010.05.034. https://www.jhltonline.org/article/S1053-2498(10)00358-X/fulltext Kittleson MM, Kobashigawa JA. Cardiac Allograft Vasculopathy: Current Understanding and Treatment. JACC Heart Fail. 2017;5(12):857-868. doi:10.1016/j.jchf.2017.07.003. https://www.jacc.org/doi/10.1016/j.jchf.2017.07.003 Velleca A, Shullo MA, Dhital K, et al. The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2023;42(5):e1-e141. doi:10.1016/j.healun.2022.10.015. https://www.jhltonline.org/article/S1053-2498(22)02187-5/fulltext
In this episode of Liver Lineup: Updates and Unfiltered Insights, hosts Kimberly Brown, MD, and Nancy Reau, MD, break down new research on liver transplantation, hepatocellular carcinoma (HCC), and the ongoing evolution of surveillance strategies in chronic liver disease. Drawing on their extensive experience as transplant hepatologists, Brown and Reau place new data into practical context, highlighting where evidence may meaningfully inform practice and where unanswered questions remain.Key episode timestamps:0:00:00 – Introduction0:00:19 – Frailty & Transplant Evaluation0:02:54 – How Centers Use Frailty Measures0:04:37 – Practicalities of the Six‑Minute Walk0:06:10 – MELD 3.0 and Sex/Size Disparities0:08:42 – Exception Points & Size Constraints0:10:05 – Need for a Dynamic MELD System0:10:19 – Immunotherapy as Bridge/Downstaging for HCC0:13:34 – Real‑World Use of IO Around Transplant0:15:22 – Managing Rejection Risk0:19:03 – MASLD Population & Surveillance Gaps0:20:21 – Adherence to HCC Surveillance0:22:42 – Practical Barriers: AFP, Ultrasound, Radiology Reports0:24:02 – Shift Toward Blood-Based Surveillance0:26:01 – How AFP-L3 and DCP Are Used in Practice0:27:39 – Rising AFP, Imaging Strategy & Broader Trend to Blood Tests0:28:27 – Guidelines vs Real-World Practice0:29:37 – Closing Thoughts on Guidelines & Early Detection
With nearly five decades of clinical experience, Mark Birch breaks down why hair health starts at the scalp—not supplements, transplants, or trends. This episode dismantles common myths, explains why hair loss has accelerated globally, and shows how daily habits, environment, stress, and product choice quietly determine whether hair thrives or thins.Key Discussion Highlights Mark explains that the scalp is the fastest-aging skin on the body and requires daily care, much like teeth or facial skin. Poor hygiene, clogged follicles, harsh chemicals, and misinformation drive unnecessary hair loss. Dubai's environment—hard water, constant air-conditioning, UV exposure, and humidity—adds extra stress, making maintenance even more critical.Hair loss is not one condition; there are 40+ types, influenced by genetics, hormones, stress, medications, nutrition, and lifestyle. While genetics set the blueprint, daily care determines how aggressively hair loss expresses. Mark emphasizes that most people spend money on treatments before fixing basics like scalp cleanliness, pH balance, and circulation—often worsening the problem.The episode also explores nutrition, stress, sleep, exercise, chemical processing, styling products, oils, and why many “natural” hacks (onions, oils, mud, DIY remedies) can actually damage the scalp. Technology like red-light therapy and circulation-boosting tools can help—but only after the foundation is right.Key Takeaways • Hair health begins with scalp hygiene, not pills or procedures • Washing the scalp daily with the right shampoo improves circulation and growth • Most hair loss is preventable or slowable with proper maintenance • Harsh chemicals, oils, and styling products clog follicles and accelerate thinning • Transplants fail without proper pre- and post-scalp care5 Things You Can Start Doing TodayWash your scalp daily with a shampoo suited to your scalp type (not trends or scents).Use a conditioner every wash and a nourishing hair mask once weekly.Stop applying oils, gels, waxes, or DIY remedies directly to the scalp.Prioritize sleep, stress reduction, protein intake, and whole-food nutrition.Treat hair like skin: cleanse after sweating, swimming, beach exposure, or heavy styling.This episode is a reset: hair health isn't complicated—but it is disciplined. Clean scalp, correct products, consistency, and respect for biology win every time.
A liver transplant improves the length and quality of life for children with liver diseases, liver tumors, or metabolic conditions that will be improved or cured with liver transplantation. The Pediatric Liver Transplant Program at C.S. Mott Children's Hospital is the first and largest program in the state. Since 1986, team members have performed more than 400 pediatric liver transplants. Learn more about this world-class program on the latest episode of The Wrap employee podcast. Check it out today! Hosted on Acast. See acast.com/privacy for more information.
Do you sometimes ask your kids questions like "are you doing ok?" or "am I causing you trauma" and then they stare at you blankly and ask if they can have candy now? All three of us have kids who are of multiple racial and ethnic ancestry. We all worry about how they will relate to various parts of their identities and if they will feel a healthy sense of belonging... but that's not the sort of thing most kids will be able to straight up tell you.So we brought on an incredibly thoughtful adult who grew up as a bi-racial person in America and we had a very honest and vulnerable discussion of what that was like for him. Daniel Tam-Claiborne is the author of Transplants, which was a 2023 PEN America Literary Award Finalist. Daniel talks about his childhood growing up in New York City with an ethnically Chinese mother who herself grew up in Cuba and his Jewish father. He discusses how he felt both insider/outsider in many aspects of his identity as a biracial person and how that has shaped his life as an adult and even now as a father of a young daughter.If you have a biracial person in your life that you care for, this one is a must-listen.
Editor's Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief, and Preeti Malani, MD, MSJ, Deputy Editor of JAMA, the Journal of the American Medical Association, for articles published from January 24-30, 2026.
In this episode of Out on the Lanai, we're heading back to Season 1 for a deep dive into "Transplant," and we've got the perfect guest to help us navigate the drama of Blanche's sister Virginia.Joining us is Barrett Blackman, host of the podcast So Good We Named It. Together, we tackle the high stakes of kidney donations, the iconic shade of the early episodes, and why the chemistry of the girls was already so lived-in by episode four.We also chat with Barrett about his latest project, The Big "Half & Half" Rewatch Podcast, where he's revisiting the early 2000s sitcom classic.Grab a cheesecake and join us on the lanai!Follow Big Half & Half Rewatch Podcast https://www.instagram.com/thebighalfandhalfpodJoin the GG VIP Club at Patreon.com/GoldenGirlsPodcastWatch video versions of the podcast on YouTube.com/OutonTheLanaiFor more Golden Girls greatness, visit OutOnTheLanai.com and follow us at...instagram.com/OutOnTheLanaiOfficialfacebook.com/GoldenGirlsPodcasttwitter.com/GoldenGirlsPodFOLLOW H. ALAN SCOTT/SADIE PINES...instagram.com/SadiePinesinstagram.com/HAlanScottlinktr.ee/HAlanScottFOLLOW KERRI DOHERTY...instagram.com/squidsytwitter.com/SquidEatSquidSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
According to recent data, fewer than half of Multnomah County residents were born in Oregon — meaning most Portlanders aren't actually from here. But adjusting to life in our wonderful city can be challenging, and it's hard to know how to start building a community. Today on City Cast Portland, we're talking with two recent transplants and friends of the show, Danielle Mangone and Chris Cary. They have tips for how to quickly find your groove — and all the ways you can make Portland really feel like home. Become a member of City Cast Portland today! Get all the details and sign up here. Who would you like to hear on City Cast Portland? Shoot us an email at portland@citycast.fm, or leave us a voicemail at 503-208-5448. Want more Portland news? Then make sure to sign up for our morning newsletter and be sure to follow us on Instagram. Looking to advertise on City Cast Portland? Check out our options for podcast and newsletter ads at citycast.fm/advertise. Learn more about the sponsors of this January 26th episode: Beaumont Jewelry The Ascent by Christopher Walker Flatbike SkillCharter