Podcasts about epicatechin

Winter health aims for runners: protect against winter infections, support the immune function and promote circulation and blood flow in the cold weather.In this episode we focus on 4 seasonal fruits and vegetables to support health and running performance during the winter months. We outline the nutritional properties of each and consider how they can form part of your meal plan with some menu ideas. Finally, we share an example 1-day meal plan using these 4 winter foods.The 4 foods we discuss are; Butternut Squash, Cranberries, Pears and BeetrootNutritional Properties of Butternut Squash – a great source of carbohydrate, Vitamin C, and B vitamins – supportive of immune system, energy production and soft tissue support.Nutritional Properties of Cranberries – packed full of phytonutrients, in particular proanthocyanidin (PAC) helpful to prevent and treat infections. Many studies highlight positive effect on urinary tract infections. The key mechanism being that PACs inhibit the adhesion of bacteria to the wall of the urinary tract.Nutritional Properties of Pears – contain the phytonutrient epicatechin, a compound thought to be involved in the contraction and relaxation of arteries, so supportive of our cardiac cardiac health.Nutritional Properties of Beetroot – contain nitrates which help promote blood flow and they have been shown to help dilate blood vessels. This helps to enable an increase and efficient flow of oxygen through the blood vessels, which clearly is going to provide us with more energy and for our running. Beet greens are also nutrient dense providing calcium, iron and vitamin C.KEY TAKE AWAYS:1.Butternut Squash for carbohydrate, vitamin C, and B vitamins for fuel, energy and supporting your immune system2.Cranberries for Proanthocyanidin (PAC) to support immune system, protect against infections, especially urinary tract infections3.Pears for Epicatechin to support blood flow and contraction and relaxation of arteries4.Beetroot for nitrates to support dilation of blood vessels and efficient flow of oxygen via blood vesselsIntroductionRelated Topics:Disclaimer:The suggestions we make during this episode are for guidance andadvice only, and are not a substitute for medical advice or treatment.If you have any concerns regarding your health, please contactyour healthcare professional for advice as soon as possible.Aileen Smith and Karen Campbell host RUNNERS HEALTH HUB. A place for like-minded female runners who are looking for simple ways to support running performance, energy, endurance, and general great health.if this is your first time your show and you'd like to know more about us and She Runs Eats Performs please check out our TRAILER.If you're ready to make learn more about how you may introduce easy nutrition into your running and training plan join our Easy Nutrition For Healthy Runners Online Programme for short videos, recipes, downloads and LIVE training and Q&A.As a THANK YOU to you as one of our valued listeners, we have a special offer for you use COUPON CODE POD to get 33% discount off the full price which brings the price to £199. If you'd like help from Karen and Aileen to design a personalised sports nutrition plan...

Cocoa may enhance skeletal muscle function University of California at San Diego, May 3, 2022 A small clinical trial led by researchers at UC San Diego School of Medicine and VA San Diego Healthcare System (VASDHS) found that patients with advanced heart failure and type 2 diabetes showed improved mitochondrial structure after three months of treatment with epicatechin-enriched cocoa. Epicatechin is a flavonoid found in dark chocolate. The study published by the journal Clinical and Translational Science looked at profoundly ill patients with major damage to skeletal muscle mitochondria. The trial participants consumed dark chocolate bars and a beverage with a total epicatechin content of approximately 100 mg per day for three months. Biopsies of skeletal muscle were conducted before and after treatment. After the three-month treatment, the researchers looked at changes in mitochondria volume and the abundance of cristae, which are internal compartments of mitochondria that are necessary for efficient function of the mitochondria, and measurable by electron microscopy. After three months, we saw recovery – cristae numbers back toward normal levels, and increases in several molecular indicators involved in new mitochondria production.” Healthy habits may improve longevity, prevent Alzheimer's disease Rush University Medical Center, May 14, 2022 Everyday habits that serve as the backbone of a healthy lifestyle may keep your brain sharp and help you live longer, according to new research from aging experts at RUSH. A study recently published in the British Medical Journal found that people ages 65 and older who had a healthy lifestyle lived longer—3.1 years longer for women, 5.7 years longer for men—than their peers who didn't have the same healthy lifestyle. They also spent more of their remaining years without Alzheimer's disease. What constitutes a healthy lifestyle?Eating the Mediterranean-DASH Intervention for Neurogenerative Delay (MIND) diet Staying engaged in cognitive activities like reading and puzzles Being physically active for at least 150 minutes a week Not smoking Limiting alcohol use (no more than one drink a day for women and two drinks a day for men) This latest study builds on ongoing research from RUSH showing that lifestyle factors can potentially reduce the risk for Alzheimer's disease and dementia by up to 60%, says Kumar Rajan, Ph.D., professor of epidemiology and director of the Rush Institute for Healthy Aging. Ozone treated water v. lethal microbial material   University of Alberta,  May 9, 2022 A University of Alberta research team has discovered that technology commonly used to decontaminate food industry equipment can also rid meat processing plants of lethal microbial material responsible for the human version of the ailment Mad Cow disease. U of A microbiology professors Mike Belosevic and Norm Neumann and engineering professor Mohamed Gamal El-Din demonstrated that infectious proteins found in the brain matter of cattle can be eradicated from water treated with ozone. The discovery could have applications in decontaminating wastewater in settings such as slaughterhouse effluents where infected neural material known as prions may be present. The ozone decontamination procedure can potentially be used to sterilize instruments used for neurosurgery, and prevent the transfer of infectious prions during surgical procedures. Prions are able to destroy and can still be infectious after being incinerated at heats of 850o C. In the wild, soil contaminated by a carcass of a deer that died of Chronic Wasting Disease can remain a source of infection for many years. The U of A research team's technique of using water treated with ozone to destroy prions is an improvement on current prion decontamination methods. Tai Chi Benefits Patients With Parkinson's Oregon Research Institute, May 13, 2022 Tai chi, an ancient martial art characterized by slow, flowing movement and meditation, helps improve balance and movement control for people with Parkinson's disease. The finding, published in The New England Journal of Medicine, is the latest study to show the benefits of tai chi for people with chronic health problems. Past studies have shown that tai chi reduces falls and depression among the elderly, and lessens pain for patients with arthritis and fibromyalgia. In the latest research, 195 people with movement and balance problems caused by Parkinson's disease were recruited from four Oregon cities. The patients were divided into three exercise classes that met for an hour a day, twice a week. One group took part in an extensive stretching class, another was taught resistance training, and the third group performed tai chi. After six months, patients in the tai chi group performed better on a number of measures related to strength, movement control, balance, stride length and reach. Resistance training also offered some benefits, and both the tai chi and resistance training groups had fewer falls than the stretching group. Vitamin B12 shows promise against ALS Tokushima University (Japan), May 13 2022.  An article appearing on May 9, 2022 in JAMA Neurology described a randomized trial in which men and women with the progressive neurologic disease amyotrophic lateral sclerosis (ALS) exhibited improvement in their condition after receiving a high dose of a form of vitamin B12 known as methylcobalamin.  Among the 126 patients who completed the trial, Amyotrophic Lateral Sclerosis Functional Rating Scale  scores declined by an average of 2.66 points for those who received the vitamin and by 4.63 in the placebo group—a difference of 43%. (Lower scores indicate increased severity of symptoms.)  This randomized clinical trial demonstrated that use of ultrahigh-dose methylcobalamin resulted in a 43% reduction in clinical deterioration as evaluated with the ALSFRS-R total score throughout the 16-week treatment period in the patients with early-stage ALS, Diabetes risk from sitting around University of Leicester (UK), May 12, 2022 A new study has found that women who stay seated for long periods of time every day are more prone to developing type 2 diabetes, but that a similar link wasn't found in men. Researchers from the University of Leicester Departments of Health Sciences and Cardiovascular Sciences revealed that women who are sedentary for most of the day were at a greater risk from exhibiting the early metabolic defects that act as a precursor to developing type 2 diabetes than people who tend to sit less. The team assessed over 500 men and women of the age of 40 or more about the amount of time spent sitting over the course of a week. It was found that the women who spent the longest time sitting had higher levels of insulin, as well as higher amounts of C-reactive protein and chemicals released by fatty tissue in the abdomen, leptin, and interleukin6, and which indicate problematic inflammation. This study provides important new evidence that higher levels of sitting time have a deleterious impact on insulin resistance and chronic low-grade inflammation in women but not men and that this effect is seen regardless of how much exercise is undertaken. This suggests that women who meet the national recommendations of 30 minutes of exercise a day may still be compromising their health if they are seated for the rest of the day. Videos: 1. Fauci Clip Surfaces, As Incoherent In 1985 As He Is Now: Spreads Diabolical Lie That “HIV” Could Spread To Children Via Casual Contact In Household (0:35) 2. Margaret Heckler & Robert Gallo – 1984 Press Conference (0:38) 3. Melissa Ciummei Clip  (9:52) 4. A terrifying prediction for 2030 (the Great Reset) (start @ 1:12) 5. New Rule: American Carnage | Real Time with Bill Maher (HBO) (7:48)

Our winter health aims as a runner, are to protect against winter infections, support the immune function and promote circulation and blood flow in the cold weather. In this episode we focus on 4 seasonal fruits and vegetables to support health and running performance during the winter months. We outline the nutritional properties of each and consider how they can form part of your meal plan with some menu ideas. Finally, we share an example 1-day meal plan using these 4 winter foods. The 4 foods we discuss are; Butternut Squash, Cranberries, Pears and Beetroot Nutritional Properties of Butternut Squash – a great source of carbohydrate, Vitamin C, and B vitamins – supportive of immune system, energy production and soft tissue support. Nutritional Properties of Cranberries – packed full of phytonutrients, in particular proanthocyanidin (PAC) helpful to prevent and treat infections. Many studies highlight positive effect on urinary tract infections. The key mechanism being that PACs inhibit the adhesion of bacteria to the wall of the urinary tract. Nutritional Properties of Pears – contain the phytonutrient epicatechin, a compound thought to be involved in the contraction and relaxation of arteries, so supportive of our cardiac cardiac health. Nutritional Properties of Beetroot – contain nitrates which help promote blood flow and they have been shown to help dilate blood vessels. This helps to enable an increase and efficient flow of oxygen through the blood vessels, which clearly is going to provide us with more energy and for our running. Beet greens are also nutrient dense providing calcium, iron and vitamin C. KEY TAKE AWAYS: Butternut Squash for carbohydrate, vitamin C, and B vitamins for fuel, energy and supporting your immune system Cranberries for Proanthocyanidin (PAC) to support immune system, protect against infections, especially urinary tract infections Pears for Epicatechin to support blood flow and contraction and relaxation of arteries Beetroot for nitrates to support dilation of blood vessels and efficient flow of oxygen via blood vessels This podcast uses the following third-party services for analysis: Chartable - https://chartable.com/privacy

https://sunny-trailblazer-4067.ck.page/cebc1ad414 (BOOK YOUR PLACE) on our next FREE TRAINING: Learn all about our Healthy Woman Healthy Runner Method. We love podcasting but we love being with you LIVE even more so we can't wait to meet you in our ZOOM ROOM!https://sunny-trailblazer-4067.ck.page/cebc1ad414 (BOOK HERE!) FOOD FOR ...... Winter Running From a health and nutritional view point our winter health aims (as a runner) are to protect against winter infections, support the immune function and promote circulation and blood flow in the cold weather. In this episode we focus on 4 seasonal fruits and vegetables to support health and running performance during the winter months. We outline the nutritional properties of each and consider how they can form part of your meal plan with some menu ideas. Finally, we share an example 1-day meal plan using these 4 winter foods. The 4 foods we discuss are; Butternut Squash, Cranberries, Pears and Beetroot (02:01) Nutritional Properties of Butternut Squash – a great source of carbohydrate, Vitamin C, and B vitamins – supportive of immune system, energy production and soft tissue support. (02:48) Nutritional Properties of Cranberries – packed full of phytonutrients, in particular proanthocyanidin (PAC) helpful to prevent and treat infections. Many studies highlight positive effect on urinary tract infections. The key mechanism being that PACs inhibit the adhesion of bacteria to the wall of the urinary tract. (04:06) Nutritional Properties of Pears – contain the phytonutrient epicatechin, a compound thought to be involved in the contraction and relaxation of arteries, so supportive of our cardiac cardiac health. (05:15) Nutritional Properties of Beetroot – contain nitrates which help promote blood flow and they have been shown to help dilate blood vessels. This helps to enable an increase and efficient flow of oxygen through the blood vessels, which clearly is going to provide us with more energy and for our running. Beet greens are also nutrient dense providing calcium, iron and vitamin C. (09:16) Food ideas for butternut squash including, roasted and stuffed with lentils, tofu and vegetables, roasting the seeds for snacks and making soups, risotto and curries (13:04) Food ideas using cranberries including, red cabbage with cranberries and apples, cranberry sauce and relish, cranberry and beetroot compote (15:39) Food ideas using pears including, pear, goats cheese and walnut salad, as an accompaniment to a cheeseboard, pear and chia jam, poached pears with chocolate, pear compote for breakfast or for a crumble (18:00) Food ideas using beetroot including, roasted for a side dish, beetroot hummus, beetroot, apple and coconut soup, a dip made with cannellini beans (21:00) Check out our suggestions for a 1-day Winter Warming Menu Plan. KEY TAKE AWAYS: · Butternut Squash for carbohydrate, vitamin C, and B vitamins for fuel, energy and supporting your immune system ·  Cranberries for Proanthocyanidin (PAC) to support immune system, protect against infections, especially urinary tract infections ·  Pears for Epicatechin to support blood flow and contraction and relaxation of arteries ·  Beetroot for nitrates to support dilation of blood vessels and efficient flow of oxygen via blood vessels Related Episodes: https://she-runs-eats-performs.captivate.fm/episode/vitamins-and-minerals-for-the-female-runner (Ep7 Vitamins and Minerals for the Female Runner) https://she-runs-eats-performs.captivate.fm/episode/endurance-running-and-immune-system (Ep14 Endurance Running and the Immune System) https://she-runs-eats-performs.captivate.fm/episode/nutrition-for-winter-running (Ep 29 Nutrition for Winter Running) Disclaimer: The suggestions we make during this episode are for guidance and advice only, and are not a substitute for medical advice or treatment. If you have any concerns regarding your health, please contact...

Ready to take your brain health to the next level? Ready to be proactive, or even reverse, the signs of brain aging? Then this episode is definitely for you! We are fortunate to have “Amazon” John Easterling, Plant Medicine Formulator, with us again this week. He dives into the plant medicine treasures he’s found in the Amazon Rainforest that beautifully support healthy brain function and help you ward off brain aging.   * * *   ABOUT "AMAZON JOHN" EASTERLING Since 1976 John Easterling has been an explorer and treasure hunter in the Amazon Rainforest. It was there, after a personal health crisis, he was introduced to the traditional use of medicinal plants by the Indigenous People in Peru.  Since then his passion for plant medicine has only accelerated. Easterling's original degree is in Environmental Studies, he founded the Amazon Herb Company in 1990 and serves on the board of the Amazon Center of Environmental Education and Research.  Amazon John’s 28 years of Plant Medicine experience have been profiled on TV and Radio including "Good Morning America" and "Fox and Friends".  His product formulations have sold over $100 million worldwide. John has been featured in two PBS documentaries, World News Report "Amazon John and Rainforest Medicines" and Jean Michel Cousteau's "Return to the Amazon."  Easterling believes the dramatic growth and interest in plant medicine is still in its early stages and will continue to significantly improve life experiences and healthy outcomes into the future.   Causes of Alzheimer’s and Dementia Beta amyloid plaquing. “So when you get plaquing, your spark plug would foul, and you couldn't start your engine. So same thing here. You get that plaquing in there, and it just can't transmit to the next one, and you don't remember. You can't access that data where you put your keys.” Tau tangle, where you get the neurons that really just become tangled. Inflammation is a really big deal, and actually these other factors are really caused by it. It's a kind of inflammatory response from your brain to protect itself sometimes, developing this amyloid plaquing to seal off what it sees as an insult. Involvement of Candida in brain issues. Recent research showed was that people did not think before that the Candida could cross the blood brain barrier. Now they found that it actually can. It travels through your body doing that, looking for a place to reside where the biological terrain is right. If you introduce a lot of sugar and a lot of carbs into that terrain, they really love that. When these Candida cross that blood brain barrier, the brain recognizes that as an insult, and then you have this coating process. The brain will try to coat that to seal it off.   Prevention Lifestyle and diet - low sugar, more green vegetables Probiotics after a course of antibiotics - maintain a diverse colony-forming units of probiotics. Maintain healthy inflammation levels throughout the body. Exercise - improves the microcirculation to the brain. Sleep - get quality sleep each night (7-9 hours). Lower your exposure to environmental toxins.   Botanicals to Improve Brain Health Una de Gato - Cat’s Claw Primarily known for its ability to stimulate the macrophage phagocytosis activity, which is our immune system. Source of epicatechins and the brain derived neurotropic. Stimulates neurogenesis - the creation of new brain cells. Camu Camu Tremendous source for a whole food vitamin C. Powerful anti-inflammatory. Increases the proper cycling of serotonin. Potent source of polyphenols, quercetin, and resveratrol. Bacopa Reduces brain amyloid levels in mice by as much as 60%. Increases cognitive function in humans. An ayurvedic plant. Cinnamon - cinnamaldehyde Able to break down tau tangles. It’s anti-inflammatory. Balances sugar levels. Cacao Is anti-inflammatory. Helps increase microcirculation in the brain. Contains epicatechins, which have been shown to be very helpful for brain chemistry and to help to slow down the death of healthy brain cells Pau d'Arco Many medicinal properties include antifungal, antimicrobial, anti-inflammatory, antiviral and anti-parasitic. Scientists have found that Pau d'Arco has a unique, two-pronged effect on fungal infections. ... In this way, it is able to kill off a variety of bacteria, fungi, and yeast, including Candida albicans. Good source of polyphenols. Anti-inflammatory. Dragon’s Blood - Sangra de Grado Pure antioxidant by dry weight. Great source of proanthocyanidins. Anti-inflammatory. Helps facilitate the breakdown of plaquing in the brain. Guayusa Substitute for caffeine. Enables ‘first time’ memories to be recalled. Anti-inflammatory.   Signs of Alzheimer’s and Dementia People may experience: Cognitive: mental decline, difficulty thinking and understanding, confusion in the evening hours, delusion, disorientation, forgetfulness, making things up, mental confusion, difficulty concentrating, inability to create new memories, inability to do simple math, or inability to recognize common things Behavioral: aggression, agitation, difficulty with self care, irritability, meaningless repetition of own words, personality changes, restlessness, lack of restraint, or wandering and getting lost Mood: anger, apathy, general discontent, loneliness, or mood swings Psychological: depression, hallucinations, or paranoia Also common: inability to combine muscle movements, jumbled speech, or loss of appetite     Deeper Dive Resources   Camu Camu https://www.healthline.com/nutrition/camu-camu#4%E2%80%937.-Other-potential-benefits   Cat’s Claw, Uña De Gato (Uncaria Tomentosa) https://wholeworldbotanicals.com/cats-claw-una-de-gato-uncaria-tomentosa/   Sangre de Drago - Dragon’s Blood https://en.wikipedia.org/wiki/Croton_lechleri   Brain-derived Neurotrophic Factor And Its Clinical Implications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697050/   Bacopa monniera Extract Reduces Amyloid Levels In Psapp Mice https://www.ncbi.nlm.nih.gov/pubmed/16914834   Why Cinnamon May Hold Secrets to Alzheimer’s Prevention https://www.alzheimers.net/cinnamon-prevents-alzheimers/   Cacao https://en.wikipedia.org/wiki/Cocoa_bean   Pau d‘Arco http://www.ucdenver.edu/academics/colleges/pharmacy/currentstudents/OnCampusPharmDStudents/ExperientialProgram/Documents/nutr_monographs/Monograph-pau_darco.pdf   Proanthocyanidins https://en.wikipedia.org/wiki/Proanthocyanidin   Guayusa https://en.wikipedia.org/wiki/Ilex_guayusa   Raphael Mechoulam https://en.wikipedia.org/wiki/Raphael_Mechoulam   Alzheimer’s & Dementia Resource Center https://adrccares.org/?gclid=EAIaIQobChMI5-i54vnU4QIVnLjACh161gXdEAAYASAAEgJ3NPD_BwE   Alzheimer’s & Dementia Facts & Figures https://www.alz.org/media/Documents/alzheimers-facts-and-figures-infographic-2019.pdf https://www.alz.org/alzheimers-dementia/facts-figures   Tau, tangles, and Alzheimer's disease https://www.sciencedirect.com/science/article/pii/S0925443904001619   Amyloid Plaques and Neurofibrillary Tangles https://www.brightfocus.org/alzheimers-disease/infographic/amyloid-plaques-and-neurofibrillary-tangles   Candidiasis https://www.health.harvard.edu/a_to_z/candidiasis-a-to-z   Plant polyphenols as dietary antioxidants in human health and disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/   Anthocyanins https://nutritionfacts.org/topics/anthocyanins/   Epicatechin https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/epicatechin   Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer’s Disease Mice https://s3.amazonaws.com/academia.edu.documents/22236175/jad_arendash_caffeine.pdf?AWSAccessKeyId=AKIAIWOWYYGZ2Y53UL3A&Expires=1555534722&Signature=n916JYzngT0Ze610mx1uCDNHAJs%3D&response-content-disposition=inline%3B%20filename%3DCaffeine_reverses_cognitive_impairment_a.pdf   Organixx’s NEW Ageless Brain - Nutrition for your brain. http://www.organixx.com/ageless-brain

Ready to take your brain health to the next level? Ready to be proactive, or even reverse, the signs of brain aging? Then this episode is definitely for you! We are fortunate to have “Amazon” John Easterling, Plant Medicine Formulator, with us again this week. He dives into the plant medicine treasures he’s found in the Amazon Rainforest that beautifully support healthy brain function and help you ward off brain aging.   * * *   ABOUT "AMAZON JOHN" EASTERLING Since 1976 John Easterling has been an explorer and treasure hunter in the Amazon Rainforest. It was there, after a personal health crisis, he was introduced to the traditional use of medicinal plants by the Indigenous People in Peru.  Since then his passion for plant medicine has only accelerated. Easterling's original degree is in Environmental Studies, he founded the Amazon Herb Company in 1990 and serves on the board of the Amazon Center of Environmental Education and Research.  Amazon John’s 28 years of Plant Medicine experience have been profiled on TV and Radio including "Good Morning America" and "Fox and Friends".  His product formulations have sold over $100 million worldwide. John has been featured in two PBS documentaries, World News Report "Amazon John and Rainforest Medicines" and Jean Michel Cousteau's "Return to the Amazon."  Easterling believes the dramatic growth and interest in plant medicine is still in its early stages and will continue to significantly improve life experiences and healthy outcomes into the future.   Causes of Alzheimer’s and Dementia Beta amyloid plaquing. “So when you get plaquing, your spark plug would foul, and you couldn't start your engine. So same thing here. You get that plaquing in there, and it just can't transmit to the next one, and you don't remember. You can't access that data where you put your keys.” Tau tangle, where you get the neurons that really just become tangled. Inflammation is a really big deal, and actually these other factors are really caused by it. It's a kind of inflammatory response from your brain to protect itself sometimes, developing this amyloid plaquing to seal off what it sees as an insult. Involvement of Candida in brain issues. Recent research showed was that people did not think before that the Candida could cross the blood brain barrier. Now they found that it actually can. It travels through your body doing that, looking for a place to reside where the biological terrain is right. If you introduce a lot of sugar and a lot of carbs into that terrain, they really love that. When these Candida cross that blood brain barrier, the brain recognizes that as an insult, and then you have this coating process. The brain will try to coat that to seal it off.   Prevention Lifestyle and diet - low sugar, more green vegetables Probiotics after a course of antibiotics - maintain a diverse colony-forming units of probiotics. Maintain healthy inflammation levels throughout the body. Exercise - improves the microcirculation to the brain. Sleep - get quality sleep each night (7-9 hours). Lower your exposure to environmental toxins.   Botanicals to Improve Brain Health Una de Gato - Cat’s Claw Primarily known for its ability to stimulate the macrophage phagocytosis activity, which is our immune system. Source of epicatechins and the brain derived neurotropic. Stimulates neurogenesis - the creation of new brain cells. Camu Camu Tremendous source for a whole food vitamin C. Powerful anti-inflammatory. Increases the proper cycling of serotonin. Potent source of polyphenols, quercetin, and resveratrol. Bacopa Reduces brain amyloid levels in mice by as much as 60%. Increases cognitive function in humans. An ayurvedic plant. Cinnamon - cinnamaldehyde Able to break down tau tangles. It’s anti-inflammatory. Balances sugar levels. Cacao Is anti-inflammatory. Helps increase microcirculation in the brain. Contains epicatechins, which have been shown to be very helpful for brain chemistry and to help to slow down the death of healthy brain cells Pau d'Arco Many medicinal properties include antifungal, antimicrobial, anti-inflammatory, antiviral and anti-parasitic. Scientists have found that Pau d'Arco has a unique, two-pronged effect on fungal infections. ... In this way, it is able to kill off a variety of bacteria, fungi, and yeast, including Candida albicans. Good source of polyphenols. Anti-inflammatory. Dragon’s Blood - Sangra de Grado Pure antioxidant by dry weight. Great source of proanthocyanidins. Anti-inflammatory. Helps facilitate the breakdown of plaquing in the brain. Guayusa Substitute for caffeine. Enables ‘first time’ memories to be recalled. Anti-inflammatory.   Signs of Alzheimer’s and Dementia People may experience: Cognitive: mental decline, difficulty thinking and understanding, confusion in the evening hours, delusion, disorientation, forgetfulness, making things up, mental confusion, difficulty concentrating, inability to create new memories, inability to do simple math, or inability to recognize common things Behavioral: aggression, agitation, difficulty with self care, irritability, meaningless repetition of own words, personality changes, restlessness, lack of restraint, or wandering and getting lost Mood: anger, apathy, general discontent, loneliness, or mood swings Psychological: depression, hallucinations, or paranoia Also common: inability to combine muscle movements, jumbled speech, or loss of appetite     Deeper Dive Resources   Camu Camu https://www.healthline.com/nutrition/camu-camu#4%E2%80%937.-Other-potential-benefits   Cat’s Claw, Uña De Gato (Uncaria Tomentosa) https://wholeworldbotanicals.com/cats-claw-una-de-gato-uncaria-tomentosa/   Sangre de Drago - Dragon’s Blood https://en.wikipedia.org/wiki/Croton_lechleri   Brain-derived Neurotrophic Factor And Its Clinical Implications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697050/   Bacopa monniera Extract Reduces Amyloid Levels In Psapp Mice https://www.ncbi.nlm.nih.gov/pubmed/16914834   Why Cinnamon May Hold Secrets to Alzheimer’s Prevention https://www.alzheimers.net/cinnamon-prevents-alzheimers/   Cacao https://en.wikipedia.org/wiki/Cocoa_bean   Pau d‘Arco http://www.ucdenver.edu/academics/colleges/pharmacy/currentstudents/OnCampusPharmDStudents/ExperientialProgram/Documents/nutr_monographs/Monograph-pau_darco.pdf   Proanthocyanidins https://en.wikipedia.org/wiki/Proanthocyanidin   Guayusa https://en.wikipedia.org/wiki/Ilex_guayusa   Raphael Mechoulam https://en.wikipedia.org/wiki/Raphael_Mechoulam   Alzheimer’s & Dementia Resource Center https://adrccares.org/?gclid=EAIaIQobChMI5-i54vnU4QIVnLjACh161gXdEAAYASAAEgJ3NPD_BwE   Alzheimer’s & Dementia Facts & Figures https://www.alz.org/media/Documents/alzheimers-facts-and-figures-infographic-2019.pdf https://www.alz.org/alzheimers-dementia/facts-figures   Tau, tangles, and Alzheimer's disease https://www.sciencedirect.com/science/article/pii/S0925443904001619   Amyloid Plaques and Neurofibrillary Tangles https://www.brightfocus.org/alzheimers-disease/infographic/amyloid-plaques-and-neurofibrillary-tangles   Candidiasis https://www.health.harvard.edu/a_to_z/candidiasis-a-to-z   Plant polyphenols as dietary antioxidants in human health and disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/   Anthocyanins https://nutritionfacts.org/topics/anthocyanins/   Epicatechin https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/epicatechin   Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer’s Disease Mice https://s3.amazonaws.com/academia.edu.documents/22236175/jad_arendash_caffeine.pdf?AWSAccessKeyId=AKIAIWOWYYGZ2Y53UL3A&Expires=1555534722&Signature=n916JYzngT0Ze610mx1uCDNHAJs%3D&response-content-disposition=inline%3B%20filename%3DCaffeine_reverses_cognitive_impairment_a.pdf   Organixx’s NEW Ageless Brain - Nutrition for your brain. http://www.organixx.com/ageless-brain

We’re talking brain health this week! And  we have a treat for you! "Amazon" John Easterling, Plant Medicine Formulator joins us in the studio to share his story. Tune in to learn  how he found a passion in plan medicine. We also dig into brain health and the causes of Alzheimer’s and dementia. * * *   ABOUT "AMAZON JOHN" EASTERLING Since 1976 John Easterling has been an explorer and treasure hunter in the Amazon Rainforest. It was there, after a personal health crisis, he was introduced to the traditional use of medicinal plants by the Indigenous People in Peru.  Since then his passion for plant medicine has only accelerated. Easterling's original degree is in Environmental Studies, he founded the Amazon Herb Company in 1990 and serves on the board of the Amazon Center of Environmental Education and Research.  Amazon John’s 28 years of Plant Medicine experience have been profiled on TV and Radio including "Good Morning America" and "Fox and Friends".  His product formulations have sold over $100 million worldwide. John has been featured in two PBS documentaries, World News Report "Amazon John and Rainforest Medicines" and Jean Michel Cousteau's "Return to the Amazon."  Easterling believes the dramatic growth and interest in plant medicine is still in its early stages and will continue to significantly improve life experiences and healthy outcomes into the future.   Evolution of a Treasure Hunter Went down to Ecuador and down into Peru, with a passion for finding lost cities of gold, essentially a treasure hunter. Was making his living with some of that material, and then some artifacts. Next, into Brazil, Uruguay, and Argentina with gemstones, and took that on as treasure. Then later going up the river in the Amazon rainforest, he was trading in blowguns and carved monkey bones, and a variety of tribal artifacts and became ill. This is where his passion for plant medicine was ignited. The natives brewed a special  tea from local plants. This not only improved his illness but  he actually felt better than ever before in his life. This is where the Amazon Herb Company was born and has helped people improve their health with plant medicine for 30 years.   How Amazon John Came to Focus on Brain Health Through research of diseases with Doctors he found eight major areas where everyone is affected, and almost every specific challenge falls within these categories: Immune System Primary Digestion Secondary Digestion (Metabolism) Energy Circulation Calming & Stress Related Issues Hormonal Balancing Inflammatory Issues (pain, sewelling) Blood Sugar Balancing The issues with Alzheimer's and dementia, when you look at the statistics, as I've really gotten into more recently, it is really shocking. It is startling. I was surprised at a lot of the data that I saw. The incidence of death from heart disease in the last 15 years has actually declined by about 11%. The deaths due to Alzheimer's have increased 123%.   Alzheimer's and Dementia by the Numbers “The issues with Alzheimer's and dementia, when you look at the statistics, as I've really gotten into more recently, it is really shocking. It is startling. I was surprised at a lot of the data that I saw.” People over 65, one in 10 have Alzheimer's dementia. Deaths of people over 65 years old, one out of three of those deaths will be due to Alzheimer's. Actually, more people are dying of Alzheimer's than prostate cancer and breast cancer combined. And the cost is 270 billion dollars now. It's expected to go to 1.4 trillion over the next few years. The Center of Disease Control said that this could break the entire health system.   Signs of Alzheimer’s and Dementia People may experience: Cognitive: mental decline, difficulty thinking and understanding, confusion in the evening hours, delusion, disorientation, forgetfulness, making things up, mental confusion, difficulty concentrating, inability to create new memories, inability to do simple math, or inability to recognize common things Behavioral: aggression, agitation, difficulty with self care, irritability, meaningless repetition of own words, personality changes, restlessness, lack of restraint, or wandering and getting lost Mood: anger, apathy, general discontent, loneliness, or mood swings Psychological: depression, hallucinations, or paranoia Also common: inability to combine muscle movements, jumbled speech, or loss of appetite   Causes of Alzheimer’s and Dementia Beta amyloid plaquing. “So when you get plaquing, your spark plug would foul, and you couldn't start your engine. So same thing here. You get that plaquing in there, and it just can't transmit to the next one, and you don't remember. You can't access that data where you put your keys.” Tau tangle, where you get the neurons that really just become tangled. Inflammation is a really big deal, and actually these other factors are really caused by it. It's a kind of inflammatory response from your brain to protect itself sometimes, developing this amyloid plaquing to seal off what it sees as an insult. Involvement of Candida in brain issues. Recent research showed was that people did not think before that the Candida could cross the blood brain barrier. Now they found that it actually can. It travels through your body doing that, looking for a place to reside where the biological terrain is right. If you introduce a lot of sugar and a lot of carbs into that terrain, they really love that. When these Candida cross that blood brain barrier, the brain recognizes that as an insult, and then you have this coating process. The brain will try to coat that to seal it off.   Prevention Lifestyle and diet - low sugar, more green vegetables Probiotics after a course of antibiotics - maintain a diverse colony-forming units of probiotics. Maintain healthy inflammation levels throughout the body. Exercise - improves the microcirculation to the brain. Sleep - get quality sleep each night (7-9 hours). Lower your exposure to environmental toxins.   Brain Health - Supplementation and Diet Polyphenols - Many of the health benefits associated with polyphenols may be related to their role as antioxidants. Antioxidants are known for their ability to combat cell damage. Anthocyanins - Powerful antioxidants - the red/blue/violet phytonutrients responsible for the vibrant pigmentation of many berries and vegetables. Brain-derived neurotrophic factor - several botanicals that help stimulate; una de gato, cat's claw Cacao - can slow down the process of brain cells dying. Cinnamon - cinnamaldehyde, has been shown to slow down, to break down amyloid plaquing, and help dissolve the tau tangles.      Deeper Dive Resources   Whole World Botanicals https://wholeworldbotanicals.com/herbal-library-with-scientific-research/   Vibrational Energy Medicine http://www.energyandvibration.com/energymedicine.htm   The Moche-Chimú Transition http://www.unm.edu/~gbawden/324-MTransition/324-MTransition.htm   Chimu Civilization https://www.ancient.eu/Chimu_Civilization/   Alzheimer’s & Dementia Resource Center https://adrccares.org/?gclid=EAIaIQobChMI5-i54vnU4QIVnLjACh161gXdEAAYASAAEgJ3NPD_BwE   Alzheimer’s & Dementia Facts & Figures https://www.alz.org/media/Documents/alzheimers-facts-and-figures-infographic-2019.pdf https://www.alz.org/alzheimers-dementia/facts-figures   Tau, tangles, and Alzheimer's disease https://www.sciencedirect.com/science/article/pii/S0925443904001619   Amyloid Plaques and Neurofibrillary Tangles https://www.brightfocus.org/alzheimers-disease/infographic/amyloid-plaques-and-neurofibrillary-tangles   Candidiasis https://www.health.harvard.edu/a_to_z/candidiasis-a-to-z   Plant polyphenols as dietary antioxidants in human health and disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/   Anthocyanins https://nutritionfacts.org/topics/anthocyanins/   Sangre de Drago - Dragon’s Blood https://en.wikipedia.org/wiki/Croton_lechleri   Brain-derived neurotrophic factor and its clinical implications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697050/   Epicatechin https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/epicatechin   Why Cinnamon May Hold Secrets to Alzheimer’s Prevention https://www.alzheimers.net/cinnamon-prevents-alzheimers/   Organixx’s NEW Ageless Brain - Nutrition for your brain. http://www.organixx.com/ageless-brain

We’re talking brain health this week! And  we have a treat for you! "Amazon" John Easterling, Plant Medicine Formulator joins us in the studio to share his story. Tune in to learn  how he found a passion in plan medicine. We also dig into brain health and the causes of Alzheimer’s and dementia. * * *   ABOUT "AMAZON JOHN" EASTERLING Since 1976 John Easterling has been an explorer and treasure hunter in the Amazon Rainforest. It was there, after a personal health crisis, he was introduced to the traditional use of medicinal plants by the Indigenous People in Peru.  Since then his passion for plant medicine has only accelerated. Easterling's original degree is in Environmental Studies, he founded the Amazon Herb Company in 1990 and serves on the board of the Amazon Center of Environmental Education and Research.  Amazon John’s 28 years of Plant Medicine experience have been profiled on TV and Radio including "Good Morning America" and "Fox and Friends".  His product formulations have sold over $100 million worldwide. John has been featured in two PBS documentaries, World News Report "Amazon John and Rainforest Medicines" and Jean Michel Cousteau's "Return to the Amazon."  Easterling believes the dramatic growth and interest in plant medicine is still in its early stages and will continue to significantly improve life experiences and healthy outcomes into the future.   Evolution of a Treasure Hunter Went down to Ecuador and down into Peru, with a passion for finding lost cities of gold, essentially a treasure hunter. Was making his living with some of that material, and then some artifacts. Next, into Brazil, Uruguay, and Argentina with gemstones, and took that on as treasure. Then later going up the river in the Amazon rainforest, he was trading in blowguns and carved monkey bones, and a variety of tribal artifacts and became ill. This is where his passion for plant medicine was ignited. The natives brewed a special  tea from local plants. This not only improved his illness but  he actually felt better than ever before in his life. This is where the Amazon Herb Company was born and has helped people improve their health with plant medicine for 30 years.   How Amazon John Came to Focus on Brain Health Through research of diseases with Doctors he found eight major areas where everyone is affected, and almost every specific challenge falls within these categories: Immune System Primary Digestion Secondary Digestion (Metabolism) Energy Circulation Calming & Stress Related Issues Hormonal Balancing Inflammatory Issues (pain, sewelling) Blood Sugar Balancing The issues with Alzheimer's and dementia, when you look at the statistics, as I've really gotten into more recently, it is really shocking. It is startling. I was surprised at a lot of the data that I saw. The incidence of death from heart disease in the last 15 years has actually declined by about 11%. The deaths due to Alzheimer's have increased 123%.   Alzheimer's and Dementia by the Numbers “The issues with Alzheimer's and dementia, when you look at the statistics, as I've really gotten into more recently, it is really shocking. It is startling. I was surprised at a lot of the data that I saw.” People over 65, one in 10 have Alzheimer's dementia. Deaths of people over 65 years old, one out of three of those deaths will be due to Alzheimer's. Actually, more people are dying of Alzheimer's than prostate cancer and breast cancer combined. And the cost is 270 billion dollars now. It's expected to go to 1.4 trillion over the next few years. The Center of Disease Control said that this could break the entire health system.   Signs of Alzheimer’s and Dementia People may experience: Cognitive: mental decline, difficulty thinking and understanding, confusion in the evening hours, delusion, disorientation, forgetfulness, making things up, mental confusion, difficulty concentrating, inability to create new memories, inability to do simple math, or inability to recognize common things Behavioral: aggression, agitation, difficulty with self care, irritability, meaningless repetition of own words, personality changes, restlessness, lack of restraint, or wandering and getting lost Mood: anger, apathy, general discontent, loneliness, or mood swings Psychological: depression, hallucinations, or paranoia Also common: inability to combine muscle movements, jumbled speech, or loss of appetite   Causes of Alzheimer’s and Dementia Beta amyloid plaquing. “So when you get plaquing, your spark plug would foul, and you couldn't start your engine. So same thing here. You get that plaquing in there, and it just can't transmit to the next one, and you don't remember. You can't access that data where you put your keys.” Tau tangle, where you get the neurons that really just become tangled. Inflammation is a really big deal, and actually these other factors are really caused by it. It's a kind of inflammatory response from your brain to protect itself sometimes, developing this amyloid plaquing to seal off what it sees as an insult. Involvement of Candida in brain issues. Recent research showed was that people did not think before that the Candida could cross the blood brain barrier. Now they found that it actually can. It travels through your body doing that, looking for a place to reside where the biological terrain is right. If you introduce a lot of sugar and a lot of carbs into that terrain, they really love that. When these Candida cross that blood brain barrier, the brain recognizes that as an insult, and then you have this coating process. The brain will try to coat that to seal it off.   Prevention Lifestyle and diet - low sugar, more green vegetables Probiotics after a course of antibiotics - maintain a diverse colony-forming units of probiotics. Maintain healthy inflammation levels throughout the body. Exercise - improves the microcirculation to the brain. Sleep - get quality sleep each night (7-9 hours). Lower your exposure to environmental toxins.   Brain Health - Supplementation and Diet Polyphenols - Many of the health benefits associated with polyphenols may be related to their role as antioxidants. Antioxidants are known for their ability to combat cell damage. Anthocyanins - Powerful antioxidants - the red/blue/violet phytonutrients responsible for the vibrant pigmentation of many berries and vegetables. Brain-derived neurotrophic factor - several botanicals that help stimulate; una de gato, cat's claw Cacao - can slow down the process of brain cells dying. Cinnamon - cinnamaldehyde, has been shown to slow down, to break down amyloid plaquing, and help dissolve the tau tangles.      Deeper Dive Resources   Whole World Botanicals https://wholeworldbotanicals.com/herbal-library-with-scientific-research/   Vibrational Energy Medicine http://www.energyandvibration.com/energymedicine.htm   The Moche-Chimú Transition http://www.unm.edu/~gbawden/324-MTransition/324-MTransition.htm   Chimu Civilization https://www.ancient.eu/Chimu_Civilization/   Alzheimer’s & Dementia Resource Center https://adrccares.org/?gclid=EAIaIQobChMI5-i54vnU4QIVnLjACh161gXdEAAYASAAEgJ3NPD_BwE   Alzheimer’s & Dementia Facts & Figures https://www.alz.org/media/Documents/alzheimers-facts-and-figures-infographic-2019.pdf https://www.alz.org/alzheimers-dementia/facts-figures   Tau, tangles, and Alzheimer's disease https://www.sciencedirect.com/science/article/pii/S0925443904001619   Amyloid Plaques and Neurofibrillary Tangles https://www.brightfocus.org/alzheimers-disease/infographic/amyloid-plaques-and-neurofibrillary-tangles   Candidiasis https://www.health.harvard.edu/a_to_z/candidiasis-a-to-z   Plant polyphenols as dietary antioxidants in human health and disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/   Anthocyanins https://nutritionfacts.org/topics/anthocyanins/   Sangre de Drago - Dragon’s Blood https://en.wikipedia.org/wiki/Croton_lechleri   Brain-derived neurotrophic factor and its clinical implications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697050/   Epicatechin https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/epicatechin   Why Cinnamon May Hold Secrets to Alzheimer’s Prevention https://www.alzheimers.net/cinnamon-prevents-alzheimers/   Organixx’s NEW Ageless Brain - Nutrition for your brain. http://www.organixx.com/ageless-brain

Die vorliegende Arbeit beschäftigt sich mit dem Einfluss von Drogenextrakten und Naturstoffen auf die endotheliale NO-Synthase (eNOS) in humanen Endothelzellen (Primärkulturen und Zelllinien). Insbesondere wurde dabei ihr Einfluss auf den verschiedenen zellulären Ebenen (Transkription, Proteinexpression, NO-Synthese) untersucht. Da es in dieser Arbeitsgruppe die erste Arbeit auf dem Gebiet der eNOS war, mussten zunächst Methoden etabliert und entwickelt werden, mit denen die eNOS auf den verschiedenen zellulären Ebenen detektiert werden kann. Etabliert wurden ein Luciferase-Reportergen-Assay zur Messung der eNOS Promotoraktivität, eine Northern Blot-Methode zur Bestimmung der eNOS-mRNA und eine Western Blot-Methode zur Messung der eNOS Proteinmenge. Entwickelt wurden ein L-Arginin/L-Citrullin Umwandlungsassay zur Bestimmung der eNOS-bedingten L-Citrullin-produktion und ein DAF-2 Fluoreszenzassay zur Messung der eNOS-bedingten NO-Produktion. Getestet wurden Extrakte und Naturstoffe, bei denen bereits positive kardiovaskuläre Eigenschaften wie Vasodilatation bekannt bzw. in der Diskussion waren. Keinen Einfluss auf die eNOS hatten: •Knoblauchextrakte und schwefelhaltige Knoblauchextraktinhaltsstoffe •Der Weißdornblüten- und Blätterextrakt WS1442 •Die Catechinderivate Epicatechin-3-gallat und Epigallocatechin-3-gallat •Die Rotweinpolyphenole Delphinidin, Quercetin, Epicatechin und Rutin Dagegen konnten Isoflavone der Sojabohne, wie Genistein, Daidzein, Formononetin, Biochanin A und Equol die eNOS Promotoraktivität konzentrationsabhängig erhöhen. Genistein (stellvertretend für alle Isoflavone im Western Blot getestet) erhöhte auch die eNOS Proteinmenge. Allerdings bewirkte Genistein, trotzt der Erhöhung der Proteinmenge, keine Erhöhung der eNOS abhängigen Bildung an L-Citrullin und NO. Positive Ergebnisse brachten die Tests mit einem Rotweinpolyphenolextrakt (RWPE). Dieser Extrakt erhöhte signifikant die NO-Produktion in den beiden getesteten Endothelzellarten (EA.hy926 Zellen und HUVECs). Um den molekularen Mechanismus der NO-Produktionserhöhung durch RWPE aufzuklären, wurden verschiedene Ebenen der eNOS Regulation untersucht. Dabei konnte in dieser Arbeit zum ersten mal gezeigt werden, dass RWPE sowohl die eNOS Promotoraktivität als auch die eNOS Proteinexpression erhöht. Die nächste Frage war, ob die NO-Produktionserhöhung kausal mit der gemessenen Transkriptionserhöhung zusammenhängt. Zeitabhängige Untersuchungen auf den verschiedenen Ebenen der eNOS Regulation ergaben ähnliche Ergebnisse mit einer signifikant messbaren Beeinflussung stets nach ca. 10 h. Dies deutet darauf hin, dass RWPE die eNOS-abhängige NO-Produktion über eine Erhöhung der eNOS Transkription/Translation erhöht. Allerdings konnte dies auf Grund fehlender Experimente über eine posttranslationelle eNOS Beeinflussung nicht eindeutig bewiesen werden. Abschließend sollte mit der Suche nach den wirksamen Bestandteilen im RWPE begonnen werden. Auch wenn im Verlauf dieser Arbeit die wirksamen Verbindungen noch nicht gefunden wurden, konnten zumindest einige Substanzen als wirksamkeitsbestimmend oder -mitbestimmend ausgeschlossen werden. Neben einigen nicht wirksamen Rotweinpolyphenolen (Delphinidin, Rutin, Quercetin, Epicatechin) geben die durchgeführten Experimente Hinweise darauf, dass auch Anthocyane, Tannine und oligomere Procyanidine unwirksam sind. Das Stilbenderivat Resveratrol, welches oft als eine kardiovaskulär aktive Komponente im Rotwein angesehen wird, hatte nur einen sehr geringen und auf der Ebene der NO-Produktion nicht signifikanten Effekt auf die eNOS. Zusammenfassend wurde in dieser Arbeit ein Modell zur Messung von Einflüssen auf die eNOS aufgebaut. Von den getesteten Extrakten und Naturstoffen beeinflusste nur RWPE signifikant die eNOS. Es konnte erstmalig gezeigt werden, dass RWPE in Endothelzellen nach Langzeitstimulation (20 h) die eNOS Transkription, eNOS Expression und eNOS bedingte NO-Produktion erhöht. Dieses Ergebnis ist physiologisch äußerst interessant. Denn bisher bekannte, die eNOS Expression erhöhende Substanzen (z.B: Östradiol, Cyclosporin A, Insulin, Phorbolester, Wasserstoffperoxid, Staurosporin, Angiotensin II) sind auf Grund ihrer vielseitigen physiologischen/toxischen Wirkungen therapeutisch zur Prophylaxe und Behandlung von kardiovaskulären Erkrankungen kaum einsetzbar. Die Aufgabe zukünftiger Arbeiten wird es sein, die Wirkung von RWPE in vivo zu untersuchen und die für die Wirkung verantwortlichen Bestandteile des RWPE zu finden.