Podcasts about noncanonical

The Bible is all we need, Gods word that He has given us. But God has given us so much more in historical context and writings that continue to prove that the Bible is the truth! We see Pauls witness is Acts, but who else witnessed Jesus or the things he did? How was that passed down?

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.02.551383v1?rss=1 Authors: Cohen, M. L., Brumwell, A. N., Ho, T. C., Montas, G., Golden, J. A., Jones, K. D., Wolters, P. J., Wei, Y., Chapman, H. A., Le Saux, C. J. Abstract: Reciprocal interactions between alveolar fibroblasts and epithelial cells are crucial for lung homeostasis, injury repair, and fibrogenesis, but underlying mechanisms remain unclear. To investigate this, we administered the fibroblast-selective TGF{beta}1 signaling inhibitor, epigallocatechin gallate (EGCG), to Interstitial Lung Disease (ILD) patients undergoing diagnostic lung biopsy and conducted single-cell RNA sequencing on spare tissue. Unexposed biopsy samples showed higher fibroblast TGF{beta}1 signaling compared to non-disease donor or end-stage ILD tissues. In vivo, EGCG significantly downregulated TGF{beta}1 signaling and several pro-inflammatory and stress pathways in biopsy samples. Notably, EGCG reduced fibroblast secreted Frizzle-like Receptor Protein 2 (sFRP2), an unrecognized TGF{beta}1 fibroblast target gene induced near type II alveolar epithelial cells (AEC2s). In human AEC2-fibroblast coculture organoids, sFRP2 was essential for AEC2 trans-differentiation to basal cells. Precision cut lung slices (PCLS) from normal donors demonstrated that TGF{beta}1 promoted KRT17 expression and AEC2 morphological change, while sFRP2 was necessary for KRT5 expression in AEC2-derived basaloid cells. Wnt-receptor Frizzled 5 (Fzd5) expression and downstream calcineurin-related signaling in AEC2s were required for sFRP2-induced KRT5 expression. These findings highlight stage-specific TGF{beta}1 signaling in ILD, the therapeutic potential of EGCG in reducing IPF-related transcriptional changes, and identify the TGF{beta}1-non-canonical Wnt pathway crosstalk via sFRP2 as a novel mechanism for dysfunctional epithelial signaling in Idiopathic Pulmonary Fibrosis/ILD. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.06.526840v1?rss=1 Authors: Rivera Alvarez, J., Asselin, L., Tilly, P., Benoit, R., Batisse, C., Richert, L., Batisse, J., Morlet, B., Levet, F., Schwaller, N., Mely, Y., Ruff, M., Reymann, A.-C., GODIN, J. D. Abstract: Completion of neuronal migration is critical for brain development. Kif21b is a plus-end directed kinesin motor protein that promotes intracellular transport and controls microtubule dynamics in neurons. Here we report a physiological function of Kif21b during radial migration of projection neurons in the mouse developing cortex. In vivo analysis in mouse and live imaging on cultured slices demonstrate that Kif21b regulates the radial glia-guided locomotion of new-born neurons independently of its motility on microtubules. Unexpectedly we show that Kif21b directly binds and regulates the actin cytoskeleton both in vitro and in vivo in migratory neurons. We establish that Kif21b-mediated regulation of actin cytoskeleton dynamics influences branching and nucleokinesis during neuronal locomotion. Altogether, our results reveal atypical roles of Kif21b on the actin cytoskeleton during migration of cortical projection neurons. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.03.526715v1?rss=1 Authors: Elezaby, A., Lin, A. J., Vijayan, V., Pokhrel, S., Bechara, L. R., Ostberg, N. P., Queliconi, B. B., Campos, J. C., Ferreira, J. C., Haileselassie, B., Mochly-Rosen, D. Abstract: Cardiac troponin I (cTnI) is a sarcomeric protein critical to myocyte contraction. Unexpectedly, we found that some cTnI localized to the mitochondrial matrix in the heart, inhibited mitochondrial functions when stably expressed in non-cardiac cells and increased opening of the mitochondrial permeability transition pore under oxidative stress. Direct, specific, and saturable binding of cTnI to ATP synthase was demonstrated in vitro, using immune-captured ATP synthase, and in cells using proximity ligation assay. cTnI binding doubled F1F0 ATPase activity, whereas skeletal troponin I and several human mutant cTnI variants associated with familial hypertrophic cardiomyopathy did not. A rationally-designed ten amino acid peptide, P888, inhibited cTnI binding to ATP synthase and cTnI-induced increase in ATPase activity in vitro and reduced cardiac injury following transient ischemia in vivo. We therefore suggest that mitochondria-associated cTnI may inhibit cardiac ATP synthase under basal conditions; pharmacological agents that release this inactivating effect of cTnI and thus preventing ATP hydrolysis during cardiac ischemia may increase the reservoir of functional mitochondria to reduce cardiac injury. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.19.512511v1?rss=1 Authors: Stamateris, R. E., Sharma, R. B., Landa-Galvan, H. V., Darko, C., Redmond, D., Rane, S. G., Alonso, L. C. Abstract: Expanding beta cell mass is a critical goal in the fight against diabetes. CDK4, an extensively characterized cell cycle activator, is required to establish and maintain beta cell number. Beta cell failure in the IRS2-deletion mouse type 2 diabetes model is in part due to loss of CDK4 regulator Cyclin D2. We set out to determine whether replacement of endogenous CDK4 with the inhibitor-resistant mutant CDK4-R24C rescued the loss of beta cell number in Irs2-deficient mice. Surprisingly, not only beta cell number but also beta cell dedifferentiation status was effectively rescued, despite no improvement in insulin sensitivity. Ex vivo studies in primary islet cells revealed a novel mechanism in which CDK4 intervened downstream in the insulin signaling pathway to prevent FOXO1-mediated transcriptional repression of critical beta cell transcription factor Pdx1. FOXO1 inhibition was not related to E2F1 activity, to FOXO1 phosphorylation, or even to FOXO1 subcellular localization, but rather was related to deacetylation of FOXO1 and reduced FOXO1 abundance. Taken together, these results demonstrate a novel differentiation-promoting activity of the classical cell cycle activator CDK4 and support the concept that beta cell mass can be expanded without compromising function. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In the screening room Angus has discovered a revealing interview given by Marjorie M. Liu as she was wrapping up her run on Astonishing X-Men. During the 2013 Melbourne Writers Festival, she came to the Wheeler Centre for an exclusive video-only interview with Joe Morris (host of the NonCanonical comics podcast). She discusses the thrills, challenges and romance of writing; the transition from her erstwhile career as a lawyer; navigating the gendered genres of romance and comics; going off the deep end with your fiction; and the value of revising your work. Marjorie M. Liu on Comics, Romance and the Joy of Writing https://youtu.be/4iezrsDRk6U Please join us in celebration of Image Comics Month: Monstress https://www.amazon.com/Monstress-Vol-1-Marjorie-Liu-ebook/dp/B01DJOS93I/ Set in an alternate matriarchal 1900's Asia, in a richly imagined world of art deco-inflected steampunk, MONSTRESS tells the story of a teenage girl who is struggling to survive the trauma of war, and who shares a mysterious psychic link with a monster of tremendous power, a connection that will transform them both. Entertainment Weekly praised MONSTRESS as "one of Image Comics' most imaginative and daring new series" and dubbed it the "Best New Original Series" in their year-end "Best Comics of 2015" list. Collects MONSTRESS #1-6 Leave a message via the anchor app at Kirby's Kids. www.anchor.fm/kirbyskids Join the Community Discussions https://mewe.com/join/kirbyskids Please join us down on the Comics Reading Trail in 2022 https://www.kirbyskids.com/2021/11/holiday-special-kirbys-kids-giving.html For detailed show notes and past episodes please visit www.kirbyskids.com

Dr. Brandon Scott interviews Dr. Shirley Paulson–the host of the Bible and Beyond podcast—about authoring a difficult chapter, “Jesus by Many Other Names,” in the new book, After Jesus Before Christianity: A Historical Exploration of the First Two Centuries of Jesus Movements. Paulson speaks of her love for the noncanonical texts of the second century, and explains how they illuminate one's understanding of Jesus, the Bible itself, and the debate over 'Gnosticism.' Shirley Paulson has a Master of Theological Studies from Garrett-Evangelical Theological Seminary, and a PhD in Religion and Theology from the University of Birmingham (UK). The unique contribution of Shirley's work is her research in noncanonical texts from the perspective of contemporary methodology in Practical Theology. She is widely regarded as an expert on the noncanonical text, The Secret Revelation of John, with a book coming out in 2022. 

This week on Slash and Burn, it's a noncanonical episode because we wanted SOMETHING to post but didn't have time for a real episode! Join us as hosts Kera, the fanfiction veteran, and Steve, the lovable noob, talk about... I don't know what because I'm just a producer and did not edit this so *shrug emoji*. I'm sure whatever they talk about is weird and funny, though. slashandburnpod.tumblr.com twitter.com/slashandburnpod tiny.cc/sbdiscord slashandburnpod@gmail.com / slashandburnpud@gmail.com

How can we be sure the story of Jesus described in the New Testament is true, given the fact that there are other ancient claims about Jesus? Do the non-canonical gospels deserve our attention as legitimate records of the life of Jesus? Is the New Testament true or just the story that prevailed when the non-canonical records were eliminated? J. Warner answers these questions in this episode of the NRBtv Cold-Case Christianity Broadcast.

This week on Slash and Burn, it's another noncanonical episode that the producers did not have time to edit! Join us as hosts Kera, the fanfiction veteran, and Steve, the lovable noob, talk about life shit! Like Steve is a dad now! And Kera's lungs are super shitty! And I don't know what else! We apologize that it's been forever. slashandburnpod.tumblr.com twitter.com/slashandburnpod tiny.cc/sbdiscord slashandburnpod@gmail.com / slashandburnpud@gmail.com

Listen to this episode on Spotify or Apple Podcasts This is part 6 of the Why Christianity class. The Bible is such a strange thing. On the one hand, it looks like a big book, on the other hand, it’s a library of books. It’s loaded with very different kinds of literature from poetry and Read more about 393 Why Christianity 6: The The Origin and Authority of the Bible (Jerry Wierwille)[…]

Listen to this episode on Spotify or Apple Podcasts This is part 6 of the Why Christianity class. The Bible is such a strange thing. On the one hand, it looks like a big book, on the other hand, it’s a library of books. It’s loaded with very different kinds of literature from poetry and Read more about 393 Why Christianity 6: The The Origin and Authority of the Bible (Jerry Wierwille)[…]

This week on Slash and Burn, it's a noncanonical episode that the producers did not have time to actually edit! Join us as hosts Kera, the fanfiction veteran, and Steve, the lovable noob, talk about... I don't know what because I'm a producer and there was no time to edit. I'm sure whatever they talk about is just fascinating, though. slashandburnpod.tumblr.com twitter.com/slashandburnpod tiny.cc/sbdiscord slashandburnpod@gmail.com / slashandburnpud@gmail.com

This week on Slash and Burn, we prove we're not dead by releasing SOMETHING! Join us as hosts Kera, the fanfiction veteran, and Steve, the lovable noob, talk about mostly video games but also answer some listener questions from Discord. slashandburnpod.tumblr.com twitter.com/slashandburnpod tiny.cc/sbdiscord slashandburnpod@gmail.com / slashandburnpud@gmail.com

This week on Slash and Burn, we got new mics and didn't want to record a full episode just in case we fucked up our settings! So, have a noncanonical episode! Join us as hosts Kera, the fanfiction veteran, and Steve, the lovable noob, chat! Exclamation point! slashandburnpod.tumblr.com twitter.com/slashandburnpod tiny.cc/sbdiscord slashandburnpod@gmail.com / slashandburnpud@gmail.com

A long time ago, in a galaxy far, far away (or actually present day in an apartment in Brooklyn), two podcast hosts had way too much free time on their hands and decided to embark on an incredible journey.  That's right, darlings!  It's...(cue music)...KILLING YOUR DARLINGS: MINISODE 23 - CLONE WARS 2003 - SEASON 3! Well, darlings, this is our FINAL Star Wars minisode!  Your hosts Dan & Chrysten have watched every Star Wars property they can stomach, so you don't have to!  It has been quite the ride and we are so grateful that you came along on this adventure with us!  We will be back with a regularly scheduled monthly full-length episode, so don't forget to RATE, REVIEW & SUBSCRIBE!

A long time ago, in a galaxy far, far away (or actually present day in an apartment in Brooklyn), two podcast hosts had way too much free time on their hands and decided to embark on an incredible journey.  That's right, darlings!  It's...(cue music)...KILLING YOUR DARLINGS: MINISODE 22 - CLONE WARS 2003 - SEASON 2! Releasing every Monday until this pandemic has ended, Dan & Chrysten are watching every Star Wars property so you don't have to!  RATE, REVIEW & don't forget to SUBSCRIBE if you want to keep receiving these minisodes as well as our monthly full length episodes!

A long time ago, in a galaxy far, far away (or actually present day in an apartment in Brooklyn), two podcast hosts had way too much free time on their hands and decided to embark on an incredible journey.  That's right, darlings!  It's...(cue music)...KILLING YOUR DARLINGS: MINISODE 21 - CLONE WARS 2003 - SEASON 1! Releasing every Monday until this pandemic has ended, Dan & Chrysten are watching every Star Wars property so you don't have to!  RATE, REVIEW & don't forget to SUBSCRIBE if you want to keep receiving these minisodes as well as our monthly full length episodes!

Dr. Tony Burke, editor of the newly released second edition New Testament Apocrypha: More Noncanonical Scriptures, explains not only what is fascinating about these ancient texts but why he thinks churches and Christians would benefit by reading them. In this interview, he offers meaning to the very bizarre stories and why they help us understand the history and evolution of the Christian church. He also talks candidly about what they do and don't do to our faith.

This week on Slash and Burn, the world is bad and brains are bad so have a noncanonical episode! Join us as hosts Kera, the fanfiction veteran, and Steve, the lovable noob, chat and answer questions from Discord! slashandburnpod.tumblr.com twitter.com/slashandburnpod tiny.cc/sbdiscord slashandburnpod@gmail.com / slashandburnpud@gmail.com

David meets with Shane Kelley at his home in Manitowoc, WI to build a top ten list of all the times Link has popped up outside of canon.CAST: David Geisler and Shane Kelley— Find a bunch of great extras on our Patreon page! — Visit our website at anotherzeldapodcast.com and even read some of our blogs! @AnotherZeldaPodcast on Instagram and @AnotherZeldaPod on Twitter Want to talk about Zelda all the time? Join our Discord! This episode features music by Mikel & GameChops, titled “Legend of Zelda” as well as "Lost Woods" from the album “Zelda & Chill” available on Apple Music and YouTube.We also feature the song "Hero of Time" by Master Sword. Twitter: @MasterSwordBand The views, information, or opinions expressed during Another Zelda Podcast are solely those of the individuals involved and do not necessarily represent those of Sixfive Media and its employees. This has been a production of Sixfive Media 2020

This week on Slash and Burn, whoops we dropped the ball on scheduling so we have a noncanonical episode! Join us as hosts Kera, the fanfiction veteran, and Steve, the lovable noob, chat because we ran out of time for a real episode! slashandburnpod.tumblr.com twitter.com/slashandburnpod tiny.cc/sbdiscord slashandburnpod@gmail.com / slashandburnpud@gmail.com

What happens when you take one of the most iconic Indie movies of all time, Remove everything about it that made it great, and add a Laugh Track, the future "Felicity" and "Goatboy"? You get a story that's a little over 37 Minutes to tell. CAUTION: More Explicit Language/content than we normally allow.

This week on Slash and Burn, we're back with what is turning out to be a yearly holiday noncanonical episode. Join us as hosts Kera, the fanfiction veteran, and Steve, the lovable noob, share little known canonical facts or popular fan theories and the other has to guess which one is which! slashandburnpod.tumblr.com twitter.com/slashandburnpod tiny.cc/sbdiscord slashandburnpod@gmail.com / slashandburnpud@gmail.com

This week on Slash and Burn, we're back with a noncanonical episode (sorry) but it gets really heavy so..   Content warning: things get really heavy for an extended time in this episode. Mental illness discussion (depression, anxiety, bipolar, OCD, ADHD, dementia, eating disorders) as well as talk of assisted suicide and death.    Please, please reach out to someone if you are experiencing a mental health crisis. It is not hopeless.    Suicide prevention hotlines by country: https://en.m.wikipedia.org/wiki/List_of_suicide_crisis_lines   Numbers and links regarding mental health for several countries: https://checkpointorg.com/global/   Please seek help if you are struggling. You are important.   slashandburnpod.tumblr.com   twitter.com/slashandburnpod   tiny.cc/sbdiscord   slashandburnpod@gmail.com / slashandburnpud@gmail.com

This week on Slash and Burn, we couldn't get Steve's schedule to work before the episode was due so producer Meghan stepped in to do a times fanfic search challenge. Join us as host Kera, the fanfiction veteran, and producer Meghan, a fanfiction noob, challenge themselves to find podcast worthy stories in 10 minutes. As always, there is explicit content not meant for most adults, let alone children. You've been warned. slashandburnpod.tumblr.com twitter.com/slashandburnpod tiny.cc/sbdiscord slashandburnpod@gmail.com / slashandburnpud@gmail.com

This week on Slash and Burn, we got a new recording rig but it didn't work and I spent 2 hours trying to get us to sound right with two microphones but it didn't work so now we recorded a bullshit episode with one mic. Join us as hosts Kera, the fanfiction veteran, Steve, the lovable noob, and Meghan, the producer, just bullshit about Christmas and horror movies and other shit. As always, there is explicit content not meant for most adults, let alone children. You've been warned. slashandburnpod.tumblr.com twitter.com/slashandburnpod tiny.cc/sbdiscord slashandburnpod@gmail.com / slashandburnpud@gmail.com

This week on Slash and Burn, we suck and don't have any fanfiction for you! But we still wanted to put something out so we've answered some burning fan questions. As always, there is explicit content not meant for most adults, let alone children. You've been warned. slashandburnpod.tumblr.com twitter.com/slashandburnpod slashandburnpod@gmail.com / slashandburnpud@gmail.com

In this rebroadcasted Christian Worldview Thinking podcast with Aaron Atwood from Summit Worldview Ministries, J. Warner Wallace discusses his story, outreach, and what makes Christianity unique among theistic religions. What is the relationship between making the case for Christianity and presenting the Gospel? What makes Christianity so different from other worldviews? For more great podcasts from Summit Worldview Ministries, please visit their podcast archive.

In this blast from the past, J. Warner finishes his examination of the ancient non-canonical writings to see what they say about Jesus. In this episode, J. Warner examines some of the better known (and more controversial) non-canonical texts: The Gospel of Judas, the Gospel of Thomas, and the Gospel of Philip. What does the non-canonical tradition tell us about the true life of Jesus? Why would these writers twist the truth in the first place? Can we have confidence in the New Testament canon?

In this blast from the past, J. Warner continues to examine the ancient non-canonical writings to see what they say about Jesus. In this episode, J. Warner examines the Gospel of Basilides, the (Greek) Gospel of the Egyptians, the Gospel of Cerinthus, the Dialogue of the Saviour, the Gospel of Mary, the Trimorphic Protennoia, the Holy Book of the Great Invisible Spirit, the Apocryphon of John, the Gospel of the Savior, the Second Apocalypse of James, and the Gospel of Marcion. Are these documents alternate eyewitness accounts? Do they express the truth about Jesus, lost over the centuries? Are there any good reasons for us to accept what they say about Jesus? Is there anything TRUE we can learn from them?

In this blast from the past, J. Warner begins to examine the ancient non-canonical writings to see what they say about Jesus. Are these documents alternate eyewitness accounts? Do they express the truth about Jesus, lost over the centuries? Are there any good reasons for us to accept what they say about Jesus? Is there anything TRUE we can learn from them?

It may not be strictly all about TV but it’s a big one and it’s full of entertainment. And it’s all dediKated. We have a rollicking time talking to writer/director, Lucas Testro about his work on quality Australian TV and also touch on his podcast, NonCanonical. It’s a fantastic show and you should all listen […]

J. Warner examines three recent efforts to recreate Jesus and talks about the historic effort to co-opt Jesus for a variety of reasons. J. Warner focuses on the use of alleged “lost” gospels and provides a number of reasons to reject these efforts. He also talks specifically about the claims of Joseph Atwill who claims “the New Testament was written by first-century Roman aristocrats” who “fabricated the entire story of Jesus Christ.”

Our theme this month is unity and this message shares how you and others can unite the “jangling discords” inside and outside of you into a symphony of tranquility and harmony so that mountains in your life can be moved.  Don’t miss this service! 

Generalized linear models (GLM) allow for a wide range of statistical models for regression data. In particular, the logistic model is usually applied for binomial observations. Canonical links for GLM's such as the logit link in the binomial case, are often used because in this case sufficient statistics for the regression parameter exist which allow for simple interpretation of the results. However, in some applications, the overall fit as measured by the p-values of goodness of fit statistics (as the residual deviance) can be improved significantly by the use of a noncanonical link. In this case, the interpretation of the influence of the covariables is more complicated compared to GLM's with canonical link functions. It will be illustrated through simulation that the p-value associated with the common goodness of link tests is not appropriate to quantify the changes to mean response estimates and other quantities of interest when switching to a noncanonical link. In particular, the rate of misspecifications becomes considerably large, when the inverse information value associated with the underlying parametric link model increases. This shows that the classical tests are often too sensitive, in particular, when the number of observations is large. The consideration of a generalized p-value function is proposed instead, which allows the exact quantification of a suitable distance to the canonical model at a controlled error rate. Corresponding tests for validating or discriminating the canonical model can easily performed by means of this function.