Podcasts about inhibits

In this episode we talk about the recent rulings of removing Fluoride from the water. We also cover Allergies and ways to support Nasal Hygiene.Guest: Nathan Jones, the CEO of Xlear, global leader in creating natural, convenient, xylitol-based sinus and oral care products that support a healthy lifestyle.We are all responsible for our own health & wellness and we can take preventative steps to safeguard our family's health this Allergy season and beyond.“Transformational Personal Hygiene Solutions” from Xlear. Get into the “Hygiene Rhythm” - “Wash your hands, brush your teeth, & wash your nose!”Xlear Nasal Spray with Xylitol- Your best line of defense is “offense”hydrate your nose morning and night to flush away toxins and other airborne contaminants to help lessen your chances of getting sick by KEEPING YOUR NASAL PASSAGES CLEAN. Works with your body to relieve sinus discomfort & help you breathe better. Inhibits germs and contaminants from sticking to the nose and sinuses through natural xylitol.Recommended by Ear, Nose, & Throat Doctors, Allergists, Pediatricians and other healthcare experts.Learn more at Xlear.com

radiantvisalia.comWord & Deed: We are Witnesses: Forgivness, Part IIwith Joseph RosalesScripture: Matthew 6:9-15, Matthew 18:21-22, Genesis 45:1-15, Ephesians 4:31-32, Psalm 38:3-4, Colossians 3:13Intro: Joseph shares his personal journey with forgiveness, emphasizing its importance and the freedom it brings. He addresses the heaviness of unforgiveness and the need to release past hurts.Key Points:Personal Testimony: Joseph shares his struggles with unforgiveness stemming from childhood abandonment and the loss of his daughter. He highlights the transformative power of forgiving his father.The Burden of Unforgiveness: Unforgiveness binds us to past pain, leading to bitterness, resentment, and emotional turmoil. It hinders our relationship with God and prevents personal growth.Decisional vs. Emotional Forgiveness:Decisional forgiveness is a choice based on duty and obedience to God's command.Emotional forgiveness involves a deeper release and healing, often accompanied by empathy and compassion.Why Forgive?Spiritual separation from God.Bitterness and resentment.Emotional and mental unrest.Inhibits personal growth.Disobedience to God's command.How to Forgive:Acknowledge the pain.Reflect on the feelings.Name the offense and the person.Repent for unforgiveness.Release the offense.Conclusion:Unforgiveness imprisons us, while forgiveness sets us free.Forgiveness is an act of the will, a choice we make regardless of our feelings.God commands us to forgive, and He provides the strength to do so.Nelson Mandela's quote: "Unforgiveness is like drinking poison and waiting for the other person to die."Call to Action:Acknowledge and address areas of unforgiveness in your life.Reflect on the pain and choose to release it.Repent for holding onto unforgiveness.Receive prayer and support from the ministry team.Participate in communion, remembering Christ's forgiveness. Support the show*Summaries and transcripts are generated using AI. Please notify us if you find any errors.

Guest: Nathan Jones, the CEO of Xlear, global leader in creating natural, convenient, xylitol-based sinus and oral care products that support a healthy lifestyle. We are all responsible for our own health & wellness and we can take preventative steps to safeguard our family's health this cold & flu season.“Transformational Personal Hygiene Solutions” from Xlear. Get into the “Hygiene Rhythm” - “Wash your hands, brush your teeth, & wash your nose!”Xlear Nasal Spray with Xylitol- Your best line of defense is “offense” this winter– hydrate your nose morning and night to flush away toxins and other airborne contaminants to help lessen your chances of getting sick by KEEPING YOUR NASAL PASSAGES CLEAN. Works with your body to relieve sinus discomfort & help you breathe better. Inhibits germs and contaminants from sticking to the nose and sinuses through natural xylitol. Recommended by Ear, Nose, & Throat Doctors, Allergists, Pediatricians and other healthcare experts Learn more at Xlear.com

Scientist Gregg Braden is back on Know Thyself today for a deeper dive into the inherent beauty of humanity and the technology that threatens it. Pulling on the threads of our last conversations, Gregg opens up about the current state of the world: from transhumanism to artificial intelligence, giving a warning message about these innovations. He provides a reframe on what we've been told about human potential: revealing that we are far greater than we know and these technologies threaten that very greatness.   Our discussion encompasses a range of critical topics, including the ongoing struggle between good and evil on Earth, the pivotal Year 2030, and the Future of Humanity. Furthermore, Gregg draws intriguing parallels to popular culture, exploring how films like "The Matrix" serve as allegories for deeper truths about our reality, prompting us to question the nature of existence itself.  Sleep Better with the Birch Mattress -  Save 25% Off Sitewide + 2 Free Eco-Rest Pillows with Mattress Purchase: http://birchliving.com/knowthyself André's Book Recommendations: https://www.knowthyself.one/books ___________ 0:00 Intro  1:59 Technology is Evolving Faster than Our Morality 11:41 Is Transhumanism an Inevitable Phase of Evolution? 19:30 Who's Really Controlling the Show? 26:13 Why We Can't Manufacture Consciousness 31:00 The Neuroscience of Our Divinity  36:50 How Our Neurons Atrophy from Technology  44:13 Science's Attempt at Cloning (and why it won't work) 50:25 Ad: Sleep Better with the Birch Mattress & Save 25% 53:32 Earth's Battle Between Good & Evil 1:09:24 How Love vs Fear Creates our Reality  1:13:11 Year 2030 & The Future of Humanity  1:26:04 Why We're Drawn to Wholeness  1:33:44 Embracing the Truth of Who You Are 1:40:55 Conclusion  ___________ New York Times best-selling author and scientist Gregg Braden is internationally renowned as a pioneer in bridging science, spirituality and the real world. Following a successful career as a Computer Geologist during the 1970s energy crisis, he worked in the 1980s as a Senior Liaison with the U.S. Air Force Space Command. In 1991 he became the First Technical Operations Manager for Cisco Systems. Since 1986 Gregg has explored high mountain villages, remote monasteries, and forgotten texts to merge their timeless secrets with the best science of today. The author of 11 award-winning books published in 38 languages, Gregg has received numerous honours, including a 2016 nomination for the prestigious Templeton Award. He has shared his presentations with The United Nations, Fortune 500 companies, and the U.S. military, as well as in media specials aired throughout the world.  Pre-order NEW Book “Pure Human”: https://a.co/d/i9LDO4m Website: https://greggbraden.com Instagram: https://www.instagram.com/gregg.braden/ ___________ Know Thyself Instagram: https://www.instagram.com/knowthyself/ Website: https://www.knowthyself.one Clips Channel: https://www.youtube.com/channel/UCJ4wglCWTJeWQC0exBalgKg Listen to all episodes on Audio:  Spotify: https://open.spotify.com/show/4FSiemtvZrWesGtO2MqTZ4?si=d389c8dee8fa4026 Apple: https://podcasts.apple.com/us/podcast/know-thyself/id1633725927 André Duqum Instagram: https://www.instagram.com/andreduqum/

In this episode we discuss an herbal tea that has the ability to potentially inhibit the growth of cancer cells.Our website: https://acupunctureismylife.com/Follow our social media for more information on acupuncture:Instagram: https://www.instagram.com/acupunctureismylife/Facebook: https://www.facebook.com/acupunctureismylifeTikTok: https://www.tiktok.com/@acupunctureismylife?lang=e

Free book is here at https://www.memorizingpharm.com/books Summary 3.20 Vancomycin  The chapter covers vancomycin, a glycopeptide antibiotic used for treating serious infections like MRSA. It works by inhibiting bacterial cell wall synthesis. Vancomycin is typically administered via IV for systemic infections and orally for C-diff. Key concerns include nephrotoxicity, ototoxicity, and "red man syndrome," which occurs with rapid infusion. Monitoring of renal function and trough levels is crucial. Multiple Choice Questions What is vancomycin primarily used to treat? a) Viral infections b) MRSA c) Fungal infections d) Diabetes How does vancomycin work? a) Disrupts protein synthesis b) Inhibits cell wall synthesis c) Increases glucose uptake d) Enhances DNA replication What condition can occur if vancomycin is infused too quickly? a) Hair loss b) Red man syndrome c) Weight gain d) Increased appetite How is vancomycin administered for systemic infections? a) Orally b) Topically c) Intravenously d) Subcutaneously Which function should be closely monitored during vancomycin therapy? a) Cardiac function b) Renal function c) Respiratory function d) Blood glucose levels Answer Key b) MRSA b) Inhibits cell wall synthesis b) Red man syndrome c) Intravenously b) Renal function

Free book is here at https://www.memorizingpharm.com/books Summary 3.17 Antiprotozoals  Chapter 3.17 discusses antiprotozoals, medications used to treat protozoan infections such as Giardia. An example is metronidazole, which disrupts protozoal folic acid synthesis. It can be administered orally, topically, or intravenously. Side effects may include seizures, peripheral neuropathies, and dizziness. Patients should avoid alcohol during treatment and be aware that the medication can cause darkened urine. Multiple Choice Questions What is a common antiprotozoal medication? a) Penicillin b) Metronidazole c) Acyclovir d) Fluconazole How does metronidazole work? a) Enhances protein synthesis b) Inhibits folic acid synthesis c) Blocks DNA replication d) Prevents cell wall formation What side effect should patients monitor while taking antiprotozoals? a) Hair loss b) Seizures c) Increased appetite d) Weight gain What should patients avoid while taking antiprotozoals? a) Dairy products b) Alcohol c) Exercise d) Salty foods What symptom might indicate a protozoal infection? a) Dry skin b) Diarrhea c) Hair growth d) Weight gain Answer Key b) Metronidazole b) Inhibits folic acid synthesis b) Seizures b) Alcohol b) Diarrhea

Free book is here at https://www.memorizingpharm.com/books Summary 3.14 Antivirals Nursing Pharmacology Chapter 3.14 discusses antivirals, a medication class used to treat viral infections. It covers subclasses like antiherpes (e.g., acyclovir), antiinfluenza (e.g., oseltamivir), anti-hepatitis, and antiretrovirals (e.g., HIV treatment). These drugs inhibit viral replication at different stages, requiring timely administration. Important considerations include monitoring renal function, medication compliance, and potential side effects like fatigue. Multiple Choice Questions Which is a common use for acyclovir? a) Bacterial infections b) Genital herpes c) Fungal infections d) Hypertension How does oseltamivir work? a) Prevents protein synthesis b) Blocks virus release c) Inhibits cell wall synthesis d) Enhances DNA replication Which virus is treated with antiretrovirals? a) Influenza b) HIV c) Hepatitis d) Herpes What is a critical monitoring aspect for patients on antivirals? a) Blood pressure b) Renal function c) Heart rate d) Blood sugar When should oseltamivir be administered for best results? a) After 5 days of symptoms b) Within 48 hours of symptom onset c) Only if fever is present d) Anytime during the illness Answer Key b) Genital herpes b) Blocks virus release b) HIV b) Renal function b) Within 48 hours of symptom onset

BUFFALO, NY- August 15, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on August 14, 2024, entitled, “A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice.” The vacuolar H+-ATPase (V-ATPase) is an ATP-dependent proton pump that functions to control the pH of intracellular compartments as well as to transport protons across the plasma membrane of various cell types, including cancer cells. Researchers Zhen Li, Mohammed A. Alshagawi, Rebecca A. Oot, Mariam K. Alamoudi, Kevin Su, Wenhui Li, Michael P. Collins, Stephan Wilkens, and Michael Forgac from Tufts University School of Medicine; Tufts University; Dana Farber Cancer Institute, Harvard Medical School; University of Minnesota School of Medicine; Prince Sattam Bin Abdulaziz University; Korro Bio; SUNY Upstate Medical University; and Foghorn Therapeutics, have previously shown that selective inhibition of plasma membrane V-ATPases in breast tumor cells inhibits the invasion of these cells in vitro. They have now developed a nanobody directed against an extracellular epitope of the mouse V-ATPase c subunit. “We show that treatment of 4T1-12B mouse breast cancer cells with this nanobody inhibits V-ATPase-dependent acidification of the media and invasion of these cells in vitro.” The research team further found that injecting this nanobody into mice implanted with 4T1-12B cells orthotopically in the mammary fat pad inhibited the metastasis of tumor cells to the lungs. “In conclusion, our results indicate that a nanobody directed against an extracellular epitope expressed on the surface of the V-ATPase is able to inhibit activity of cell surface V-ATPases in 4T1-12B breast cancer cells, inhibit in vitro invasion of these cells and inhibit metastasis of these cells to lung following their implantation in the mammary fat pad of mice.” DOI - https://doi.org/10.18632/oncotarget.28638 Correspondence to - Michael Forgac - michael.forgac@tufts.edu Video short - https://www.youtube.com/watch?v=4eLGqvSfAgg Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28638 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, vacuolar ATPase, breast cancer, invasion, tumor metastasis, tumor growth About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

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When you think of Rahab, you most likely think of the prostitute who helped hide the Israelite spies from the enemy. (See Joshua 2). But that is not the Rahab I'm talking about … The Lord revealed a water spirit named Rahab; hovering over cities, countries, states, and nations, affecting people worldwide! Rahab is a prideful, quarrelsome, arrogant sea monster looking to impede your relationships and time of crossing over to your God given purpose. Truth is, many people think this is the Leviathan spirit, while Rahab has been getting a "free hall pass" to mess with your life. Listen to this headful prophetic word so you can be prepared!  Blessings xo- Melia's Services -> https://meliadiana.com/our-services Melia's Books ->https://meliadiana.com/books Melia's Courses -> https://meliadiana.com/vertical-relationship-academy FREE Resources - > https://meliadiana.com/resources  

Exclusive Book's removal of "From the River to the Sea" colouring book inhibits freedom of speech by Radio Islam

The longevity research world is exploding right now, it's so exciting and the technology is advancing in leaps and bounds and we are able now to discover faster than ever before thanks to AI and co to test more molecules that can impact human health than ever before in the history of mankind. What would have taken years now takes weeks or months. In this episode I talk to Michael Antonelli CEO and founder of Healthgevity. Michael is a master formulator who has spent decades in the anti-ageing and longevity space learning at the feet of many masters and who is at the forefront of working with companies at the cutting edge in peptide and bioactive ingredient development. All his formulations are science backed with clinical research and I was excited to learn about something of these novel molecules Introduction to Healthgevity and its CEO, Michael Antonelli Overview of Healthgevity's approach: merging clinical research, AI, and medical expertise Exploring the importance of longevity in today's society Michael Antonelli's journey and motivation behind founding Healthgevity The role of cutting-edge science in developing longevity supplements How Healthgevity collaborates with clinical practitioners and doctors Deep dive into Healthgevity's science-backed formulations Examples of specific ingredients and their benefits in promoting longevity The impact of AI in optimizing formulations and personalizing supplementation Addressing common misconceptions about longevity supplements Future prospects and advancements in the longevity industry   BIO   Throughout a career spanning over 17 years, Michael passionately devoted himself to pioneering methods aimed at enhancing longevity, optimizing healthspan, and elevating overall quality of life. His focus revolves around collaborating with leading healthcare professionals, researchers, and other likeminded healthcare leaders to create natural solutions that elevate patient outcomes. Michael utilizes his past experiences that integrates a diverse range of therapies and services, spanning from precision diagnostics to practice management strategies, hormone optimization, nutritional supplements, and leveraging peptides. Previous roles included Chief Innovation Officer, Executive Director, and Business Development for leading companies within the healthcare industry before founding Healthgevity. His expertise extends beyond conventional approaches, emphasizing holistic well-being and personalized care as essential components to any successful medical practice. By championing novel methodologies and innovative technologies, Michal facilitates transformative changes within the healthcare landscape, fostering advancements that positively impact both practitioners and the individuals they serve.  Michael continues to remain dedicated to the pursuit of innovative strategies that enhance health and vitality while reshaping the paradigms of healthcare.   Some of the products mentioned in this podcast:   CARDIO NAD+ Vascular health and aging are the most important health care problem in the world today. Healthy aging requires healthy arteries and a healthy heart. Cardio NAD+ is a state-of-the-art solution which uses the most novel ingredients available to help optimize cardiovascular health. As one of the most important systems in your body, we have designed this combination to be synergistic to the many different areas of cardiovascular health while demonstrating cardioprotective effects including the emerging connection between NAD+ and heart health. Featured Supportive Benefits: Improves net NAD+ status by supporting both its synthesis and limiting its degradation Supports healthy blood pressure Improves vascular aging and endothelial function Supports healthy fibrinolytic activity and clotting function Promotes healthy circulation and blood flow Inhibits platelet & red blood cell aggregation Decreases blood viscosity Supports clinical measures of inflammation Supports healthy blood sugar and insulin levels Inhibits lipid peroxidation Supports healthy lipid metabolism Demonstrated reduction in various independent cardiovascular risk factors   Resolve+ Resolve+ contains numerous compounds that have been found to reduce the inflammatory response by targeting a variety of mechanisms.  Acmella oleracea ("jambu") is sourced from Sardinia, Italy and rich in alkylamides mainly represented by spilanthol. Its flowers are widely used in folk medicine to treat toothache due to tingling, numbness, and local anesthesia caused in the mouth.  Acmella oleracea has been shown to be active in fatty acid amide hydrolase (FAAH) inhibition the enzyme responsible for the degradation of fatty acid amides and cannabinoid type 2 (CB2) activation.  There are almost 100 studies suggesting the supportive potential for anti-inflammatory, antioxidant, and analgesic effects of Acmella. Studies reported in this review confirmed activities of Acmella, postulating that transcription factors of the nuclear factor-κB family (NF-κB) trigger the transcription iNOS and COX-2 and several other pro-inflammatory mediators, such as IL-6, IL-1β, and TNF-α. Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L.), has been well documented to exhibit various health benefits. There have been many claims on the health benefits of curcumin on neurological, cardiovascular, lung, metabolic, and liver function, mainly through its anti-inflammatory and antioxidant properties. Despite its promising potential, the clinical application of curcumin has been limited due to its low bioavailability. To enhance curcumin absorption, we are the first to feature Theracurmin Super® 85X, a proprietary curcumin utilizing the latest technology that transforms standard curcumin into an amorphous structure. Theracurmin Super® 85X uses the latest technology to transform regular curcumin particles into a more bioavailable structure. This is done by splitting curcumin particles' crystal structure amorphous, therefore, making it easily absorbed and bioavailable to maximize its supportive potential. Tetrahydrocurcumin (4-HC) is the key bioactive derivative of curcumin, it's also given credibility as the engine behind all that curcumin brings to the table. With a newfound ability to extract and isolate the compound, research has even seen tetrahydrocurcumin outperform its parent compound in several tests of its capabilities. Researchers have also confirmed that 4-HC attenuated pro-inflammatory indicators like interleukin-1, interleukin-6, TNF-⍺, and prostaglandin E2.  After reviewing the data, we found many advantages to infuse tetrahydrocurcumin as CurcuPrime® stacked with Theracurmin Super® 85X into Resolve+. Quercetin is a well-known studied dietary flavonoid ubiquitously present in various vegetables. Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production.  Multiple studies have confirmed its supportive potential as an immune modulator and its ability to support a healthy inflammatory response. It can improve the Th1/Th2 balance, and restrain antigen specific IgE antibody formation However, chemical instability, poor water solubility and low bioavailability of quercetin greatly limit its applications which is why a phytosome technology which we feature in resolve is the preferred delivery system to overcome these limitations.  This enhanced form of quercetin has been shown to be as much as 20 times better absorbed than other quercetin options.  Casperome®  boswellia phytosome is a potent extract made from the resin of Boswellia serrata trees and is also referred as Indian frankincense. Boswellia extracts have been demonstrated to be effective in the management of various inflammatory response functions including those that occur in the bowel, joints, bones, respiratory airways and in the brain. The mechanism of action that involves the modulation of the natural inflammatory response both acting on prostanoid synthesis (mPGE2S) and protein degradation (caspases), and transcription factors (Nf-κB).  We have selected Casperome® which is a highly standardized in boswellic acids to match the natural composition of boswellia, formulated with phytosome technology to achieve optimized absorption and has been validated by over 10 human studies. Perilla frutescens is an annual herb belonging to the mint family (Lamiaceae). It is mainly produced in countries like China, Japan, India, Thailand and Korea. Recently, Perilla is gaining more attention because of its medicinal benefits and phytochemical contents. The functional compounds of Perilla Seed Extract are flavonoid Aglycons – polyphenols such as Luteolin, Apigenin, Chrysoeriol, and Rosemarinic Acid. Studies have shown that Perilla seed polyphenols regulate allergic and inflammatory response due to its 5-lipoxygenase inhibitory activity and suppression potential of histamine release from mast cells. AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous which contain astragaloside I, II, IV and ginsenoside Rb1. AstraGin® has been shown to provide full-spectrum gut support through enhanced absorption, microbiota and immune cell viability, and supporting a health. AstraGin® has been shown in numerous studies to increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. Additionally, AstraGin® was shown to reduce intestinal inflammatory biomarker MPO, the pro-inflammatory cytokines IL-6, IL-17, and IL-1β in ulcerative colitis patients. Prime Gut Health Prime Gut Health was created because the digestive system is the foundation of getting and staying healthy. There are many benefits to an optimal digestive system such as a healthy immune system and the protection against harmful viruses, bacteria, fungi, and yeast. The ingredients selected in Prime Gut Health work together to help restore gut homeostasis and GI barrier function.    There are many benefits to taking Prime Gut Health, including:  Supports healthy GI barrier function*   Helps restore gut homeostasis* Binds and neutralizes bacterial toxins in the gut*  Promotes a healthy immune system and respiratory health* Supports digestive health and gut discomfort*  Increased nutrient absorption*  Supports gut inflammation especially within the intestinal wall*  Promotes a healthier GI environment* Promoted regularity and healthy bowel function*    WHAT MAKES PRIME GUT HEALTH SO IMPACTFUL? ImmunoLin® is the branded ingredient serum-derived bovine immunoglobulin/protein isolate (SBI) with over 40 human studies demonstrating its clinical efficacy in digestive and immune health.   SBI has been shown to be a broad-spectrum modulator of the immune system by targeting excessive or imbalanced immunity.* In addition, ImmunoLin® works by binding, neutralizing, and removing pathogenic bacteria, viruses, and other gut irritants that can lead to inflammation.* It also helps to repair the gut lining and restore gut homeostasis.*   Tributyrin (as CoreBiome®) is a postbiotic and the most important short-chain fatty acid (SCFA) for supporting digestive, gut, immune and gastrointestinal health. CoreBiome® is a unique butyrate formula intended to pass intact through the stomach and small intestine to deliver butyrate right where it's needed—the colon.  CoreBiome® supports: Delivery of butyrate to the colon where it helps maintain the integrity of your intestinal lining* Helps repair the gut lining and restore gut homeostasis*  Tight junctures in the intestinal lining*  Regularity and regulation of a normal inflammatory response* Sporebiotics:  Soil-based probiotics have been touted for their stability, ability to improve digestion, stimulate the immune system, and help maintain a healthy gut microbiota. Bacillus coagulans SNZ 1969®, Bacillus subtilis SNZ 1972 and Bacillus clausii SNZ 1971 are supported with an over 50 year history of use and over 30 human studies covering gut health, gastrointestinal discomfort, immunity against GI tract pathogens, inhibition of food borne pathogens, inhibition of bacteria causing dental carries and gingivitis along with bacterial vaginosis. AstraGin® is a 100% natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous,  containing astragaloside I, II, IV and ginsenoside Rb1. AstraGin® enhances nutrient absorption by up-regulating nutrient transporters, such as CAT1, SGLT1, and FR. AstraGin® restores gut wall integrity by triggering an anti-inflammatory response and activating the mTOR pathway for rapid intestinal stem cell migration and differentiation in the inflamed intestinal mucosal barrier (epithelial cell and tight junction). AstraGin® promotes gut ecosystem homeostasis by the symbiotic effect of restoring gut wall integrity and increasing microbiota-immunity communication.  AstraGin® activates the immune system through the symbiotic effect of improved gut wall integrity and enhanced microbiota-immunity communication. AstraGin® demonstrated in a recent published human clinical trial, to improve upon a number of measurable factors relating to gut health making it an ideal addition into Prime Gut Health.  PrimeTime  Prime Time is a comprehensive blend of 12 key natural ingredients shown to have a role in supporting age management powered by industry leading 10mg's of spermidine per serving.  Prime Time has been formulated with ingredients to mimic fasting and catalyze your body's natural ability to rid itself of aged cells.  Various publications demonstrate the potential this formula will have in your longevity protocols as Prime Time was formulated to support:   Epigenetic aging*  Boosting autophagy and promote cellular renewal*  Fasting* Memory, cognition, and brain health* Cardiovascular health* Beauty from within* Mitochondria*  WHAT MAKES PRIME TIME SO IMPACTFUL? Spermidine Spermidine, a natural polyamine, plays a critical role in molecular and cellular interactions involved in various physiological and functional processes. Spermidine has been shown to modulate aging, suppress the occurrence and severity of age-related diseases, and prolong lifespan.  The concentration of spermidine declines with age, and exogenous spermidine supplementation reverses age- associated adverse changes and supports health span. Given that it interacts with various molecules, spermidine influences aging through diverse mechanisms.  Autophagy is the body's way of cleaning out damaged cells, to regenerate newer, healthier cells and is the main mechanism of spermidine. In addition, spermidine exerts its effects through other mechanisms, including anti-inflammation, histone acetylation reduction, lipid metabolism and regulation of cell growth and signaling pathways. Nicotinamide mononucleotide  Nicotinamide mononucleotide, a naturally occurring molecule present in all species.  NMN is rapidly absorbed and converted to NAD+, which evidence shows declines as we age.  In numerous studies, supplementation has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, and improves neuronal function in the brain among much more. Epigallocatechin-3-gallate (EGCG)  Epigallocatechin-3-gallate (EGCG) is the major catechin in green tea.  There is consistency in the literature about the beneficial role of green tea on senescence-related mechanisms, thanks to its scavenging properties against reactive oxygen species (ROS) and reactive nitrogen species (RNS) and its ability to stimulate autophagy  Alpha-ketoglutarate (AKG) Alpha-ketoglutarate (AKG) is a molecule involved in several metabolic and cellular pathways that declines with age. It works as an energy donor, a precursor in amino acid production, and a cellular signaling molecule, and it is a regulator of epigenetic processes.  Dihydroquercetin (Taxifolin)  Dihydroquercetin is a powerful antioxidant of plant origin that can protect cells from the harmful effects of free radicals and protect cell membranes against damage Apigenin Apigenin is a natural bioactive plant polyphenol with antioxidant, anti-inflammatory and immune system boosting properties.  It also helps to support against oxidative stress for better cellular function. Studies have shown that apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels. Luteolin Luteolin is a flavonoid naturally found in plants. Flavonoids like luteolin have been found to have beneficial effects on human health by reducing oxidative stress.   Trimethylglycine (TMG) Trimethylglycine (TMG) is an amino acid derivative that occurs in plants and has been shown to support methylation which, in turn, supports the homocysteine levels. Taking TMG along with NMN provides the ideal balance for NAD+ production in the body.  Resveratrol  Resveratrol is part of a group of compounds called polyphenols, which act as antioxidants to protect the body against age-related conditions.The anti-aging mechanisms of resveratrol are mainly modulating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol is considered for the prevention and support of aging and age-related diseases as it mimics the effects of calorie restriction.  Pterostilbene Pterostilbene is a phenolic compound in the same family as resveratrol and is present in small amounts in a large variety of foods and beverages like blueberries or red wine. Multiple studies confirm pterostilbene's remarkable anti-aging effects. Cell and animal studies have shown that pterostilbene can extend the lifespan of various animal models of human longevity by regulating three major pathways linked to longevity: mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and sirtuins Bergamot Bergamot (Citrus bergamia) is a type of citrus fruit native to Italy. It has been shown that bergamot juice exerts antioxidant, cardioprotective properties and antisenescence effects.  AstraGin®  AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous. AstraGin® increases the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up-regulating absorption-specific m RNA and transporters such as SGLT1, CAT1, and GLUT4. Check out all the healthgevity products in our shop.    Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with:  Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals  Nutristat Omega 3 to 6 status and more  Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa    Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission.  Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to  Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to  https://www.buymeacoffee.com/LisaT to donate $3   Lisa's Anti-Aging and Longevity Supplements  Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world.  This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.   Subscribe to our popular Youtube channel  with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube   Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge"  Check them all out at  https://shop.lisatamati.com/collections/books   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here:    Use code "tamati" at checkout to get a 10% discount on any of their devices.   Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38   Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off     Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts.  To pushing the limits, Lisa and team

BUFFALO, NY- March 19, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 5, entitled, “PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation.” Cellular senescence is a permanent cell cycle arrest that can be triggered by both internal and external genotoxic stressors, such as telomere dysfunction and DNA damage. The execution of senescence is mainly by two pathways, p16/RB and p53/p21, which lead to CDK4/6 inhibition and RB activation to block cell cycle progression. While the regulation of p53/p21 signaling in response to DNA damage and other insults is well-defined, the regulation of the p16/RB pathway in response to various stressors remains poorly understood. In this new study, researchers Chitra Palanivel, Lepakshe S. V. Madduri, Ashley L. Hein, Christopher B. Jenkins, Brendan T. Graff, Alison L. Camero, Sumin Zhou, Charles A. Enke, Michel M. Ouellette, and Ying Yan from the University of Nebraska Medical Center report a novel function of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase, as a potent inhibitor of p16 expression and senescence induction by ionizing radiation (IR), such as γ-rays. “During natural aging, there is a gradual accumulation of p16-expressing senescent cells in tissues [76]. To investigate the significance of PR55α in this up-regulation of p16, we compared levels of the p16 and PR55α proteins in a panel of normal tissue specimens derived from young (≤43 y/o) and old (≥68 y/o) donors.” The results show that ectopic PR55α expression in normal pancreatic cells inhibits p16 transcription, increases RB phosphorylation, and blocks IR-induced senescence. Conversely, PR55α-knockdown by shRNA in pancreatic cancer cells elevates p16 transcription, reduces RB phosphorylation, and triggers senescence induction after IR. Furthermore, this PR55α function in the regulation of p16 and senescence is p53-independent because it was unaffected by the mutational status of p53. Moreover, PR55α only affects p16 expression but not p14 (ARF) expression, which is also transcribed from the same CDKN2A locus but from an alternative promoter. In normal human tissues, levels of p16 and PR55α proteins were inversely correlated and mutually exclusive. “Collectively, these results describe a novel function of PR55α/PP2A in blocking p16/RB signaling and IR-induced cellular senescence.” DOI - https://doi.org/10.18632/aging.205619 Corresponding authors - Michel M. Ouellette - mouellet@unmc.edu, and Ying Yan - yyan@unmc.edu About Aging-US: Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer's diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases. Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). Please visit our website at https://www.Aging-US.com​​. MEDIA@IMPACTJOURNALS.COM

The longevity research world is exploding right now, it's so exciting and the technology is advancing in leaps and bounds and we are able now to discover faster than ever before thanks to AI and co to test more molecules that can impact human health than ever before in the history of mankind. What would have taken years now takes weeks or months. In this episode I talk to Michael Antonelli CEO and founder of Healthgevity. Michael is a master formulator who has spent decades in the anti-ageing and longevity space learning at the feet of many masters and who is at the forefront of working with companies at the cutting edge in peptide and bioactive ingredient development.    All his formulations are science backed with clinical research and I was excited to learn about something of these novel molecules like Peptistrong, Astragin, Factor 21, NAD3, Ameal Peptide and many more.   In this episode Michael walks us through some of the cutting edge molecules, what they do and how they impact various biological pathways to  hopefully improve our healthspan and lifespan.   If after listening to this episode you want to check out some of the range we now have in our shop. Click the links below:   Ignite  -Metabolic health and weightloss  Ignite+ is an exclusive breakthrough formula combining the leading ingredients available to increase metabolism, improve insulin signaling, body composition, reduce uptake of glucose into our bodies, and so much more. One of the best ways to prevent insulin resistance is to help remove excess glucose from our blood. We are the first to pair these several effective glucose disposal agents together to target several vital pathways that regulate metabolic efficiency. Ignite+ is an advanced metabolic optimization formula whose ingredients have been shown to support: Reduction of adiposity and visceral fat* Increase thermogenesis by raising the metabolic rate and calorie burning* Browning of white adipose tissue* Diet-induced weight gain* Increase fatty acid oxidation* Ramp up ketone levels* Improves glucose tolerance and glucose control* AMPK activation* Leptin and ghrelin levels* Regulation of a healthy metabolism and mitochondrial health*   Longevity  Biological aging is directly impacted by physiological integrity. Muscle strength, mass, function, quantity, and quality loss are some of the main issues associated with the process of aging. As we age the performance of our muscle cells decline which leads to a weakened immune system, sarcopenia, obesity, and chronic disease among much more. Healthgevity has selected PeptiStrong™, Senactiv® and AstraGin® which are all clinically proven ingredients to put your muscles in the best position to thrive regardless of your age. In a recent study it was concluded that lower muscle strength in late adolescence showed direct connection with higher risk of chronic disease. As such, skeletal muscle might be the central integrator between sarcopenia, obesity, immune senescence and more in an aging biological system. Preserving muscle mass is critical for optimizing health span.  Research shows the strongest one-third of the population over the age of 60 has a 50% lower death rate than the weakest, making muscle a key predictor of longevity.  Recent discoveries of clinically proven 'growth promoting' ingredients have made the process of building and preserving muscle more obtainable.  PeptiStrong™, Senactiv® and AstraGin® work synergistically to target multiple mechanisms, to provide a wide range of benefits in muscle health.  CARDIO NAD+ Vascular health and aging are the most important health care problem in the world today. Healthy aging requires healthy arteries and a healthy heart. Cardio NAD+ is a state-of-the-art solution which uses the most novel ingredients available to help optimize cardiovascular health. As one of the most important systems in your body, we have designed this combination to be synergistic to the many different areas of cardiovascular health while demonstrating cardioprotective effects including the emerging connection between NAD+ and heart health. Featured Supportive Benefits: Improves net NAD+ status by supporting both its synthesis and limiting its degradation Supports healthy blood pressure Improves vascular aging and endothelial function Supports healthy fibrinolytic activity and clotting function Promotes healthy circulation and blood flow Inhibits platelet & red blood cell aggregation Decreases blood viscosity Supports clinical measures of inflammation Supports healthy blood sugar and insulin levels Inhibits lipid peroxidation Supports healthy lipid metabolism Demonstrated reduction in various independent cardiovascular risk factors Rejuvenate Cellular senescence is a hallmark of aging, it is a permanent state of cell cycle arrest induced by cellular stresses. This has numerous implications for the body, including its ability to adapt to changes in its environment, as well as its capacity to regenerate itself. This can be beneficial for individuals to understand how cellular senescence works and what the potential benefits are for the body.  Firstly, understanding cellular senescence can help us better understand aging, as this process is a major contributor to the aging process.  Additionally, it can also provide insight into certain diseases and conditions that may be linked to the inability of cells to divide and proliferate properly.  Finally, by targeting cellular senescence, we may be able to find new ways of fighting against aging and diseases associated with it.  Thus, understanding ways to best support cellular senescence can be a powerful tool in our pursuit of longevity and improved health span.  Senolytics, are small molecules that can selectively kill senescence cells and have been developed to support various age-related diseases while also extending healthspan. In recent years, emerging natural compounds have been discovered to be effective senolytic agents that are featured in this breakthrough formula. Clearance of senescent cells can support the reduction of inflammation, decrease macromolecular dysregulation, and enhance function of stem and progenitor cells. Rejuvenate presents a unique solution for intervention through two mechanisms:  (1) eliminating senescent cells (senolytics)   (2) inhibiting of senescent- associated secretory phenotype (SASP)  Featured benefits:  Once weekly pulsed high dosing blend of senolytics which have been shown to reduce senescent cells in vivo. Targets aging at the cellular level Induces autophagy to promote intracellular recycling and cellular renewal Reduce full body features of Senescence-Associated Secretory Phenotype (SASP). Protects cells against free radicals and oxidative stress  Targets inflammaging at the cellular level and supports a healthy inflammatory response Supports a healthy immune system  Formula designed to also treat muscle senescence. Exercises muscles longer and harder with a boost in citrate synthase activity. Recovers more effectively with a reduction in inflammation biomarkers. Decreases SA-β-Gal by 63% in muscle tissue.     For more information on Michael and Healthgevity you can also go to www.healthgev.com   BIO Throughout a career spanning over 17 years, Michael passionately devoted himself to pioneering methods aimed at enhancing longevity, optimizing healthspan, and elevating overall quality of life. His focus revolves around collaborating with leading healthcare professionals, researchers, and other likeminded healthcare leaders to create natural solutions that elevate patient outcomes.  Michael utilizes his past experiences that integrates a diverse range of therapies and services, spanning from precision diagnostics to practice management strategies, hormone optimization, nutritional supplements, and leveraging peptides. Previous roles included Chief Innovation Officer, Executive Director, and Business Development for leading companies within the healthcare industry before founding Healthgevity. His expertise extends beyond conventional approaches, emphasizing holistic well-being and personalized care as essential components to any successful medical practice.  By championing novel methodologies and innovative technologies, Michal facilitates transformative changes within the healthcare landscape, fostering advancements that positively impact both practitioners and the individuals they serve.  Michael continues to remain dedicated to the pursuit of innovative strategies that enhance health and vitality while reshaping the paradigms of healthcare.   Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges.   Topics Lisa can help with:  Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals  Nutristat Omega 3 to 6 status and more  Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa    Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission.  Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to  Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to  https://www.buymeacoffee.com/LisaT to donate $3   Lisa's Anti-Aging and Longevity Supplements  Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world.  This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.   Subscribe to our popular Youtube channel  with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube   Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge"  Check them all out at  https://shop.lisatamati.com/collections/books   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here:    Use code "tamati" at checkout to get a 10% discount on any of their devices.   Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38   Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off     Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts.   To pushing the limits, Lisa and team

BUFFALO, NY- December 27, 2023 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction.” Angelica gigas NAKAI (AG) is a popular traditional medicinal herb widely used to treat dyslipidemia owing to its antioxidant activity. Vascular disease is intimately linked to obesity-induced metabolic syndrome, and AG extract (AGE) shows beneficial effects on obesity-associated vascular dysfunction. However, the effectiveness of AGE against obesity and its underlying mechanisms have not yet been extensively investigated. In this new study, researchers Geum-Hwa Lee, Hwa-Young Lee, Young-Je Lim, Ji-Hyun Kim, Su-Jin Jung, Eun-Soo Jung, Soo-Wan Chae, Juwon Lee, Junghyun Lim, Mohammad Mamun Ur Rashid, Kyung Hyun Min, and Han-Jung Chae from Jeonbuk National University and Jeonbuk National University Hospital supplemented 40 high fat diet (HFD) rats with 100–300 mg/kg/day of AGE to determine its efficacy in regulating vascular dysfunction. “[...] the primary aim of this study is to examine the inhibitory effects of AGE on dyslipidemia-associated vascular dysfunction, with a focus on its potential mechanisms of action.” The vascular relaxation responses to acetylcholine were impaired in HFD rats, while the administration of AGE restored the diminished relaxation pattern. Endothelial dysfunction, including increased plaque area, accumulated reactive oxygen species, and decreased nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) Ser1177 phosphorylation, were observed in HFD rats, whereas AGE reversed endothelial dysfunction and its associated biochemical signaling. Furthermore, AGE regulated endoplasmic reticulum (ER) stress and IRE1α sulfonation and its subsequent sirt1 RNA decay through controlling regulated IRE1α-dependent decay (RIDD) signaling, ultimately promoting NO bioavailability via the SIRT1-eNOS axis in aorta and endothelial cells. Independently, AGE enhanced AMPK phosphorylation, additionally stimulating SIRT1 and eNOS deacetylation and its associated NO bioavailability. Decursin, a prominent constituent of AGE, exhibited a similar effect in alleviating endothelial dysfunctions. These data suggest that AGE regulates dyslipidemia-associated vascular dysfunction by controlling ROS-associated ER stress responses, especially IRE1α-RIDD/sirt1 decay and the AMPK-SIRT1 axis. “Ultimately, this study presents clearly evidence that AGE is a promising natural product-based functional food/herbal medicine candidate for preventing or regulating hyperlipidemic cardiovascular complications.” DOI - https://doi.org/10.18632/aging.205343 Corresponding authors - Kyung Hyun Min - khmin1492@jbnu.ac.kr, and Han-Jung Chae - hjchae@jbnu.ac.kr About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Visit https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ MEDIA@IMPACTJOURNALS.COM

It's fairly common for EA orgs to provide fiscal sponsorship to other EA orgs.  Wait, no, that sentence is not quite right. The more accurate sentence is that there are very few EA organizations, in the legal sense; most of what you think of as orgs are projects that are legally hosted by a single org, and which governments therefore consider to be one legal entity. Source:https://www.lesswrong.com/posts/XvEJydHAHk6hjWQr5/ea-orgs-legal-structure-inhibits-risk-taking-and-informationNarrated for LessWrong by TYPE III AUDIO.Share feedback on this narration.[125+ Karma Post] ✓

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: EA orgs' legal structure inhibits risk taking and information sharing on the margin, published by Elizabeth on November 5, 2023 on The Effective Altruism Forum. What is fiscal sponsorship? It's fairly common for EA orgs to provide fiscal sponsorship to other EA orgs. Wait, no, that sentence is not quite right. The more accurate sentence is that there are very few EA organizations, in the legal sense; most of what you think of as orgs are projects that are legally hosted by a single org, and which governments therefore consider to be one legal entity. The king umbrella is Effective Ventures Foundation, which hosts CEA, 80k, Longview, EA Funds, Giving What We Can, Asterisk magazine, Centre for Governance of AI, Forethought Foundation, Non-Trivial, and BlueDot Impact. Posts on the castle also describe it as an EVF project, although it's not listed on the website. Rethink Priorities has a program specifically to provide sponsorship to groups that need it. LessWrong/Lightcone is hosted by CFAR, and have sponsored at least one project themselves (source: me. It was my project). Fiscal sponsorship has a number of advantages. It gets you the privileges of being a registered non-profit (501c3 in the US) without the time-consuming and expensive paperwork. That's a big deal if the project is small, time-limited (like mine was) or is an experiment you might abandon if you don't see results in four months. Even for large projects/~orgs, sharing a formal legal structure makes it easier to share resources like HR departments and accountants. In the short term, forming a legally independent organization seems like a lot of money and effort for the privilege of doing more paperwork. The downsides of fiscal sponsorship …are numerous, and grow as the projects involved do. The public is rightly suspicious about projects that share a legal entity claiming to be independent, so bad PR for one risks splash damage for all. The government is very confident in its belief that you are the same legal entity, so legal risks are shared almost equally (iamnotalawyer). So sharing a legal structure automatically shares risk. That may be fixable, but the fix comes at its own cost. The easiest thing to do is just take fewer risks. Don't buy retreat centers that could be described as lavish. And absolutely, 100%, don't voluntarily share any information about your interactions with FTX, especially if the benefits to doing so are intangible. So some amount of value is lost because the risk was worth it for an individual or small org, but not to the collective. [it is killing me that I couldn't follow the rule of three with that list, but it turns out there aren't that many legible, publicly visible examples of decisions to not share information] And then there are the coordination costs. Even if everyone in the legal org is okay with a particular risk, you now have an obligation to check with them.The answer is often "it's complicated", which leads to negotiations eating a lot of attention over things no one cares that much about. Even if there is some action everyone is comfortable with, you may not find it because it's too much work to negotiate between that many people (if you know anyone who lived in a group house during covid: remember how fun it was to negotiate safety rules between 6 people with different value functions and risk tolerances?). Chilling effects A long, complicated (but nonetheless simplified)example The original version of this story was one paragraph long. It went something like: A leader at an EVF-sponsored project wanted to share some thoughts on a controversial issue, informally but in public.The comments were not riskless, but this person would happily have taken the risk if it affected only themselves or their organization. Someone at EVF said no. Boo, grrr. I sent that versi...

This episodes goes in about how we can choose to grow and flourish and we can also be the ones choosing to remain stagnant and unfulfilled. Happy Growing!

How will the judge's decision to recuse himself from the last remaining drug case against former senator Leila De Lima affect the pace of the litigation? One of her lawyers, Dino De Leon, joins Christian Esguerra in this episode.

Visit: https://nursing.com/140meds to request your free copy of "140 Must Know Meds" Generic Name Epinephrine Trade Name Adrenalin, EpiPen Indication Asthma and COPD exacerbations, allergic reactions, cardiac arrest, anesthesia adjunct Action Affects both beta1 and beta2 also has alpha agonist properties resulting in bron- chodilation and increases in HR and BP. Inhibits hypersensitivity reactions. Therapeutic Class Antiasthmatic, bronchodilator, vasopressor Pharmacologic Class Adrenergic agonist Nursing Considerations • Side effects include: angina, tachycardia, hypertension, restlessness, nervousness, hyperglycemia • Use with MAOI may lead to hypertensive crisis • Patients should not use stimulants (caffeine, guarana, etc) • Excessive use may cause bronchospasm • Assess lung sounds, pulse, BP, and other hemodynamic parameters • Monitor for chest pain • Instruct patient to use as directed • Patient should insure adequate fluid intake to liquefy secretions • Mouth should be rinsed after inhalation • Beta blockers may negate effects • May increase blood glucose levels

Our desire to be in control can, so to say, limit the miracles which Hashem may otherwise bless us with. Sources

References Free Radical Biology and Medicine Volume 71, June. Pages 1-15 Cardiovasc.Res. 2012 May 1; 94(2): 379–390. Int. J. Mol. Sci. 2020, 21(7), 2578; https://doi.org/10.3390/ijms21072578 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

Ultraprocessed Food Inhibits Bone Growth Dr. Robert Lustig • http://www.robertlustig.com • Book - Metabolical #RobertLustig#BigFood #BigPharma #BigGovernment Dr. Robert Lustig is a The New York Times bestselling author and author of Metabolical: The Lure and the Lies of Processed Food, Nutrition, and Modern Medicine and a Professor of Pediatric Endocrinology at the University of California, San Francisco.  Dr. Robert Lustig, a pediatric neuroendocrinologist who has long been on the cutting edge of medicine and science, challenges our current healthcare paradigm which has gone off the rails under the influence of Big Food, Big Pharma, and Big Government. You can't solve a problem if you don't know what the problem is. One of Lustig's singular gifts as a communicator is his ability to “connect the dots” for the general reader, in order to unpack the scientific data and concepts behind his arguments, as he tells the “real story of food” and “the story of real food.” Metabolical weaves the interconnected strands of nutrition, health/disease, medicine, environment, and society into a completely new fabric by proving on a scientific basis a series of iconoclastic revelations, among them: • Medicine for chronic disease treats symptoms, not the disease itself• You can diagnose your own biochemical profile • Chronic diseases are not "druggable," but they are "foodable" • Processed food isn't just toxic, it's addictive• The war between vegan and keto is a false war—the combatants are on the same side• Big Food, Big Pharma, and Big Government are on the other side Making the case that food is the only lever we have to effect biochemical change to improve our health, Lustig explains what to eat based on two novel criteria: protect the liver, and feed the gut. He insists that if we do not fix our food and change the way we eat, we will continue to court chronic disease, bankrupt healthcare, and threaten the planet. But there is hope: this book explains what's needed to fix all three. Dr. Lustig has become a leading public health authority on the impact sugar has on fueling the diabetes, obesity and metabolic syndrome epidemics, and on addressing changes in the food environment to reverse these chronic diseases. A native of Brooklyn, New York, graduated from Massachusetts Institute of Technology and received his M.D. from Cornell University Medical College. He completed his pediatric residency at St. Louis Children's Hospital, his clinical fellowship at UCSF, his post-doctoral fellow and research associate in neuroendocrinology at The Rockefeller University. He has been a faculty member at the University of Wisconsin-Madison, and the University of Tennessee, Memphis. In 2013, Dr. Lustig received his Masters in the study of Law from University of California, Hastings to enable him to impact the food industry through policy change. Dr. Lustig has authored 125 peer-reviewed articles and 73 reviews. He has mentored 20 pediatric endocrine fellows, and trained numerous other allied health professionals. He provides endocrinologic support to several protocols of the Children's Oncology Group. He is the former Chairman of the Ad hoc Obesity Task Force of the Lawson Wilkins Pediatric Endocrine Society, a member of the Pediatric Obesity Practice Guidelines Subcommittee of The Endocrine Society, a member of the Obesity Task Force of the Endocrine Society, a member of the Pediatric Obesity Devices Committee of the U.S. Food and Drug Administration, a member of the Bay Area Board of Directors of the American Heart Association, and a member of the Steering Committee of Health Foods, Healthy Kids of the Culinary Institute of America. He also consults for several childhood obesity advocacy groups. Dr. Lustig lives in San Francisco with his wife Julie and two daughters. Spare time (what little there is) is spent cooking, theater-going, and traveling. To Contact Dr Robert Lustig, M.D.  go to robertlustig.com Disclaimer:Medical and Health information changes constantly. Therefore, the information provided in this podcast should not be considered current, complete, or exhaustive. Reliance on any information provided in this podcast is solely at your own risk. The Real Truth About Health does not recommend or endorse any specific tests, products, procedures, or opinions referenced in the following podcasts, nor does it exercise any authority or editorial control over that material. The Real Truth About Health provides a forum for discussion of public health issues. The views and opinions of our panelists do not necessarily reflect those of The Real Truth About Health and are provided by those panelists in their individual capacities. The Real Truth About Health has not reviewed or evaluated those statements or claims. 

References Cell Research. 2022. volume 32, pages 687–690 . --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

References Molecular Cancer 2020. volume 19, Article number: 39. Adv Exp Med Biol. 2021; 1301:41-57 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

A new research paper was published in Oncotarget's Volume 14 on February 2, 2023, entitled, “Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC).” TP53 mutant head and neck squamous cell carcinoma (HNSCC) patients exhibit poor clinical outcomes with 50–60% recurrence rates in advanced stage patients. In a recent phase II clinical trial, adjuvant therapy with everolimus (mTOR inhibitor) significantly increased 2-year progression-free survival in p53 mutated patients. TP53-driven mTOR activation in solid malignancies causes upregulation of HIF-1α and its target, downstream effector VEGF, by activating STAT3 cell signaling pathway. In this recent study, researchers Md Maksudul Alam, Janmaris Marin Fermin, Mark Knackstedt, Mackenzie J. Noonan, Taylor Powell, Landon Goodreau, Emily K. Daniel, Xiaohua Rong, Tara Moore-Medlin, Alok R. Khandelwal, and Cherie-Ann O. Nathan from LSU-Health Sciences Center investigated the effects of everolimus on the STAT3/HIF-1α/VEGF pathway in TP53 mutant cell lines and xenograft models. “The role of mTOR inhibitors (mTORi) as potent growth inhibitory and antiangiogenic/anti-lymphangiogenic agents in HNSCC is well established [18]. Moreover, mTORi significantly suppressed baseline invasiveness of endothelial and HNSCC tumor cells [19]. However, the underlying molecular mechanisms for mutant p53 protein-mediated activation of the mTOR pathway which drive the oncologic processes in HNSCC are yet to be elucidated.” Treatment with everolimus significantly inhibited cell growth in vitro and effectively reduced the growth of TP53 mutant xenografts in a minimal residual disease (MRD) model in nude mice. Everolimus treatment was associated with significant downregulation of STAT3/HIF-1α/VEGF pathway in both models. Further, treatment with everolimus was associated with attenuation in tumor angiogenesis and lymphangiogenesis as indicated by decreased microvessel density of vascular and lymphatic vessels in HN31 and FaDu xenografts. Everolimus downregulated the STAT3/HIF-1α/VEGF pathway to inhibit growth and in vitro tube formation of HMEC-1 (endothelial) and HMEC-1A (lymphatic endothelial) cell lines. “Our studies demonstrated that everolimus inhibits the growth of TP53 mutant tumors by inhibiting angiogenesis and lymphangiogenesis through the downregulation of STAT3/HIF-1α/VEGF signaling.” DOI: https://doi.org/10.18632/oncotarget.28355 Correspondence to: Cherie-Ann O. Nathan - cherieann.nathan@lsuhs.edu Keywords: TP53 mutant, HNSCC, angiogenesis, everolimus, mTOR About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Episode80-Ilana Horn, "How 'Best Practices' Talk Inhibits Teacher Learning"

The function of the brain is to help us survive in any way that it can.Restricting our diet can trigger this survival mechanism and switch on intense cravings.Understand that the brain is not your enemy and learn how to work with its natural functions. When you can do that, weight loss becomes effortless.Do you believe losing weight is only about changing your diet or how much you eat?You need to understand what you're up against1 - The brain isn't your enemy2 - Food cues are everywhere3 - Depriving yourself creates temptation4 - What's with the “All or Nothing” rules?Now that you understand that your brain works this way, the psychological rules that govern your thinking can be helpful in overcoming these forces. You can successfully change your eating habits in a way that allows for sustainable weight loss. Support the show

Welcome to another episode of Mid-South Gardening featuring Vador Vance, Kenneth Mabry, and Jim Crowder! The Master Gardener group joins the conversation in this episode!See omnystudio.com/listener for privacy information.

Keith Parker has over 13 years of experience in meditation and the healing arts, and he is an adept facilitator and teacher of consciousness transformation. He has an unusual extrasensory perception, which he has utilised in an innovative energy healing modality he co-founded, called Field Dynamics. He is passionate about bridging the gap between science & spirituality and empowering others to find their own authenticity, health and freedom to self-transformation and self-actualisation.  

In this episode, I speak about the comfort zone, how to push yourself out of it and why it's so important.

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Sierra: Hello Dr Cabral, And thank you so much for everything. You have been such an amazing mentor to my husband and I and we are loving the IHP course, can't wait for level 2! I had my first child two years ago (2019) with no complications during pregnancy. The only “complication” that I can say is that for a few hours after giving birth I couldn't urinate on my own, which led to a catheter insertion to empty my bladder. I'm not sure if this can be related but I've been having this excruciating pain every month for two years, about 14days or so after my period (which made me believe it could be Mittelschmerz) that basically Inhibits me from living a normal life for 2-3 days. I can't walk and if I do I'm hunched over holding my left lower abdomen (where my ovary is) due to a constant dull inflamed pain. Any how, I have been to the ER countless amount of times, have had blood work, seen multiple specialist, and I have been left with the same depressing answers “everything's normal” or “you're probably stressed because you are a new mom”… It's been two years and the only options they are giving me is birth control (which I tried for 6 months and it didn't help) or exploratory surgery. What would you recommend or what could be the reasons to why I'm having this on going pain? Thanks again   Alicja (Ah-leets-yah): Hi Dr.Cabral, Thank you for all your amazing work! I hope you can help me with my gut question: I've been dealing with gut issues for a while. I took probiotics daily and it wasn't until I found your podcast and learned that with people like me, probiotics may make things worse. I stopped taking probiotics and I noticed less bloating, however my mood dropped down significantly. I understand the gut-brain connection and I know I need to heal my gut to feel mentally happy too. Taking probiotics daily helped me stay happy and positive, but I noticed big shift in mood when I don't take them. I feel depressed. I'm currently on Para Support protocol (next will be CBO) Any advice for me during my protocols. Should I suck it up for a bit and still avoid probiotics for a while. Or should I start taking probiotics again and along with Para Support? Maybe just s.boulardii? Any advice would be appreciated. Thank you again for all you do.   Darren: Good day Dr Cabral. I don't know if a trigger warning is needed prior to this question but is semen retention something that's actually beneficial for men? That is going days, weeks, even months with intentionally minimising ejaculating usually done by either abstention, stopping (intercourse or self pleasure) before the point of ejaculation, or learning how to climax without ejaculating. While I'm seeing many anecdotal benefits I understand some in ayurveda say that's Prajnyaparadha (unhealthy suppression). I know you usually have a more balanced approach. Will appreciate your take on this.   Malissa: Day two very Nauseous. Took the day off, Just did a dry brush, Epsom bath and drank water mixed with sea salt and lemons (Supposed to be a natural Gatorade). I did sweat so that's good. Unfortunately. Suggestions for Nausea?   Francesca: Hi Dr. Cabral. I am a type 1 diabetic, female and 24 y/o. When I was 20 y/o, I started restrictive eating and my weight dropped significantly over the course of a year, as did my estrogen levels (below the charts). At that point, I was put on HRT and given doses of estradiol, and progesterone. I also began ED recovery. 3 years later, I have put on 50 pounds while still needing to eat very restrictive, my metabolism is very low, and most concerningly, I am experiencing blood sugars above 500 every day (very low carb diet!). My question is, What EXACTLY breaks a fast? I believe the HRT/ ED recovery has caused insulin resistance, and causes me to take insulin even when in a fasted state. is the insulin itself breaking a fast? There are a lot of studies that interchange the action of eating w/ the action of insulin secretion, but because I am a diabetic, one does not automatically follow the other. I just began taking Triphala, and noticed it has lowered blood glucose. But again, is this a fix to lowering insulin needs, or is this essentially processing the same as insulin, and furthering fat deposits? Your past podcasts on fasting suggests a lot of things that cause a glucose spike will break a fast, but does not truly define if its the insulin causing the fast break. Thanks!   Jenna: I heard that Glyphosate will be banned in the US started in 2023. Is that true?? I am praying   Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/2374 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!

Download the cheat: https://bit.ly/50-meds  View the lesson: https://bit.ly/EpinephrineEpiPenNursingConsiderations    Generic Name Epinephrine Trade Name Adrenalin, EpiPen Indication Asthma and COPD exacerbations, allergic reactions, cardiac arrest, anesthesia adjunct Action Affects both beta1 and beta2 also has alpha agonist properties resulting in bron- chodilation and increases in HR and BP. Inhibits hypersensitivity reactions. Therapeutic Class Antiasthmatic, bronchodilator, vasopressor Pharmacologic Class Adrenergic agonist Nursing Considerations • Side effects include: angina, tachycardia, hypertension, restlessness, nervousness, hyperglycemia • Use with MAOI may lead to hypertensive crisis • Patients should not use stimulants (caffeine, guarana, etc) • Excessive use may cause bronchospasm • Assess lung sounds, pulse, BP, and other hemodynamic parameters • Monitor for chest pain • Instruct patient to use as directed • Patient should insure adequate fluid intake to liquefy secretions • Mouth should be rinsed after inhalation • Beta blockers may negate effects • May increase blood glucose levels

Trade: NormodyneClass: Beta blocker MOA:  Binds with beta1, beta2 and Alpha1 receptors. Inhibits the strength of the hearts contractions, as well as heart rate. This results in decrease in cardiac Oxygen consumption. Indication: ACS, SVT, severe HTNContraindications: Hypotension, Cardiogenic shock, acute pulmonary edema, heart failure, severe bradycardia, Sick sinus syndrome, second or third degree heart block, bronchospasm. Side effects: Usually mild, Hypotensive symptoms, N/V, Bronchospasm, arrhythmia, bradycardia, AV blockDosing: Adult 10mg IV/IO Over 1-2mins may repeat every 10 mins to a max dose of 150mgPedi 0.4-1mg/kg per hour to a max dose of 3mg/kg per hour

Trade: Inderal Class: Beta Blocker MOA: Nonselective Beta antagonist that binds with both the beta1 and beta 2 receptors. Inhibits the strength of the hearts contractions, as well as decreases heart rate resulting in decreased cardiac O2 consumptionIndication: Angina, reentry SVT, Atrial Fibrillation, Atrial Flutter. Contraindication: Cardiogenic shock, Heart failure, AV block, bradycardia, pulmonary edema, sick sinus syndrome.Side effects:  Bradycardia, AV block, Bronchospasm, hypotension. Dosing:Adult: 1-3mg IV/IO Slow IVPPediatric: 0.01 to 0.1mg/kg slow IVP

Trade: PrimacorClass: Inotropic / VasodilatorMOA: Positive inotropic drug and vasodilator with minimal chronotropic effects. Inhibits enzyme cAMP phosphodiesterase which results in an increased concentration of calcium inside the cardiac cell and results in better diastolic function and myocardial contractility. Indication: Cardiogenic shock, Heart failureContraindication: Valvular heart disease.Side effects: Cardiac arrhythmias, N/V, Hypotension Dosing:Adult: 50 Mcg/kg IV/IO over 10 minsPedi:SAA

Paper discussed in today's episode: The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium

In this week's episode we discuss the role of HEATR3 variants as a new cause of Diamond-Blackfan anemia, learn more about the long-term efficacy and safety of zanubrutinib in relapsed or refractory mantle cell lymphoma, and uncover an unexpected role for HMGB1 in anemia of inflammation by inhibiting erythropoietin signaling.

This week, I invite you to explore the phenomenal capacities for creativity within yourself so you can do the work of releasing them. Judgment prevents us from releasing these capacities to the world and it stops us from dialoguing with our higher self. So, tune in today to see where judgment is playing a role in your de-genuising and some questions you can ask to start re-genuising.    Get full show notes and more information here: https://www.leahcb.com/179

In this episode of WaterCooler Neuroscience, we discuss Wilf's first experimental chapter of his thesis. This is when a scientist prepares an experiment and in their dissertation will write a chapter to explain and describe that experiment to other scientists. This experiment is looking at how the brain can decide to inhibit or 'turn off' regions that are competing with what we want to be doing. In reality, the brain can't turn anything off, it is more like putting a state where it is just ticking over but ready to go if it needs to. Wilf talks about his experience of designing the experiment while Jordana Adler is the host and brings her insight from the world of neurofeedback.

Fear is the elephant in the room of many professional services firms, fear of not knowing an answer, looking stupid, making a mistake, or “failing” in some way. Jeff Munn, a recovering consultant turned leadership coach, tells us how to recognize and address this obstacle so your firm can realize its growth potential. The post How Fear Inhibits Growth in Professional Services appeared first on Rattle and Pedal.

UN Special Rapporteur Alena Douhan Report on Human Rights on the Impact on Unilateral Coercive Measures on Venezuela following her 2/1- 2/12/21 visit is reviewed. It called for an immediate end to the US and Allied sanctions on Venezuela. The report found that sanctions have resulted in economic and human calamities for the entire population especially the poor and most vulnerable. While billions in Venezuelan assets that could be used for medicine and vaccines remain frozen at foreign banks the report claimed some 2.5 million Venezuelans now face severe food security. With the hardening of the sanctions over the years since 2005, state revenues to Caracas have been slashed by a staggering 99% leaving the country to live on just 1% of its presanction income. The UN rapporteur concluded by urging the US and UK and other allies, to “review and lift targeted sanctions in accordance with principle of international law, the rule of law, human rights and refugee law.” Please join us Monday night 5/31 at 6pm as our guest and investigative journalist Roger Harris brings light into the darkness around the well-hidden history of Venezuela that reveals the predatory nature of US relations with Venezuela and the south. More compelling is the detailed nature of the Venezuelan democracy and electoral process compared to US and other nations of the world that our guest explicates. In addition, the false image making that our government and its obedient mainstream media conduits feed and shape US public opinion around the issue of who is the real president of Venezuela, the US led “alleged” Venezuelan president Juan Guiado or the elected President Nicholas Maduro, is discussed in detail and explained. While surly the government of Venezuela led by its President Nicholas Maduro has made its share of mistakes that have led in part to the economic problems facing Venezuela today, this show brings light to the staggering influence US led foreign policy has had on the resulting consequences for Venezuelans. Our one-sided media coverage results in mistaken US public perceptions around who is most responsible for the Venezuelan economic meltdown. The dialogue between our guest, Board Member of the human rights organization Task Force on the Americas, Roger Harris and host Pedro Gatos provides documentable historical and contemporary insights, combining a macro and micro analysis of a host of Venezuelan related fact vs fiction precepts we may each have, for you to rejudge and reconsider for yourself as desired.

UN Special Rapporteur Alena Douhan Report on Human Rights on the Impact on Unilateral Coercive Measures on Venezuela following her 2/1- 2/12/21 visit is reviewed. It called for an immediate end to the US and Allied sanctions on Venezuela. The report found that sanctions have resulted in economic and human calamities for the entire population especially the poor and most vulnerable. While billions in Venezuelan assets that could be used for medicine and vaccines remain frozen at foreign banks the report claimed some 2.5 million Venezuelans now face severe food security. With the hardening of the sanctions over the years since 2005, state revenues to Caracas have been slashed by a staggering 99% leaving the country to live on just 1% of its presanction income. The UN rapporteur concluded by urging the US and UK and other allies, to “review and lift targeted sanctions in accordance with principle of international law, the rule of law, human rights and refugee law.” Please join us Monday night 5/31 at 6pm as our guest and investigative journalist Roger Harris brings light into the darkness around the well-hidden history of Venezuela that reveals the predatory nature of US relations with Venezuela and the south. More compelling is the detailed nature of the Venezuelan democracy and electoral process compared to US and other nations of the world that our guest explicates. In addition, the false image making that our government and its obedient mainstream media conduits feed and shape US public opinion around the issue of who is the real president of Venezuela, the US led “alleged” Venezuelan president Juan Guiado or the elected President Nicholas Maduro, is discussed in detail and explained. While surly the government of Venezuela led by its President Nicholas Maduro has made its share of mistakes that have led in part to the economic problems facing Venezuela today, this show brings light to the staggering influence US led foreign policy has had on the resulting consequences for Venezuelans. Our one-sided media coverage results in mistaken US public perceptions around who is most responsible for the Venezuelan economic meltdown. The dialogue between our guest, Board Member of the human rights organization Task Force on the Americas, Roger Harris and host Pedro Gatos provides documentable historical and contemporary insights, combining a macro and micro analysis of a host of Venezuelan related fact vs fiction precepts we may each have, for you to rejudge and reconsider for yourself as desired.

Leo's channel: https://www.youtube.com/c/LeoandLongevity

This episode is the 2nd of a 3 part Series Awakening To Sovereignty. In this episode, we will discuss the limiting beliefs that hold you back from experiencing true growth and transformation on your spiritual awakening journey. To Book A FREE Clarity Call - Click Here Apply For 1:1 Coaching

Cocktails, stories, and a brand new supplement with Suzanne Somers www.SuzanneSomers.com On this episode of The Suzanne Somers Podcast, Suzanne and her husband Alan Hamel, (Big Al), are having out in Aig Al's Bar. Join them for an evening of Cocktails, stories, and a brand new supplement Suzanne has found, that will be the talk of the health world. RestoreLife Formulas Senolytic Activator Supplement https://www.suzannesomers.com/products/restorelife-formulas-senolytic-activator-supplement Help Manage Senescent Cell Burden and Promote Systemic Rejuvenation Combines black tea theaflavins with an ultra-absorbable form of quercetin to help manage senescent cell burden and promote systemic rejuvenation. Fight back against cellular senescence! Cellular senescence is a natural part of the aging process in which cells no longer function optimally. Senescent cells can accumulate over time, affecting the day-to-day function of the healthy cells around them. Senolytic compounds selectively target senescent cells. Black tea theaflavins and quercetin target specific biological pathways, helping the body to manage senescent cells. Better Absorbed Quercetin Standard quercetin is hard to absorb. But Senolytic Activator features our new quercetin phytosome, a phospholipid sphere that encases the quercetin, aiding in its absorption and making it up to 50 times more bioavailable. Ability to ease senescent cell burden Inhibits inflammatory factors Up to 50 times more bioavailable than traditional quercetin Lessen accumulation of senescent cells Regulates key inflammatory mediators thus helping to preserve cellular integrity Posses strong antioxidant properties, which can help mitigate oxidative stress to cells and tissues. Shop along by visiting: https://www.suzannesomers.com/collections/facebook-live Suzanne Somers new book - A New Way to Age: The Most Cutting-Edge Advances in Antiaging. https://www.suzannesomers.com/pages/a-new-way-to-age Find out what Suzanne is up to and go to SuzanneSomers.com for more info on all of her incredible products. Suzanne Somers is one of America's most popular and beloved personalities. In a multifaceted career that has spanned more than three decades, she has achieved extraordinary success as an actress, singer, comedienne, New York Times bestselling author, Las Vegas Entertainer of the Year, entrepreneur, and lecturer. She is the voice and face of alternative medicine. She received an Emmy nomination as Outstanding Host for “The SUZANNE Show,” her weekly Lifetime Network talk show, which provides a thought-provoking morning show alternative with in-depth information on health and wellness in a casual, entertaining format. Suzanne's fun, smart, empowering talk show, “Suzanne Somers' Breaking Through,” airs online on the CafeMom Studios YouTube channel. For Healthy, Clean Living Suzanne Somers has developed beauty and health products that are pure and clean, easy and fun! Suzanne Somers beauty products are made with natural botanical extracts, enzymes, skin-nurturing anti-oxidants, organic fruits, and vegetables. From nourishing skin-care to flawless make-up, these products were designed to help you glow. For an in-home fitness experience, Suzanne Somers delivers products for amazing results. Her simple, achievable guidelines for exercising and eating right help you look and feel better. With her products and fitness plans, you'll be eating right and looking great while committing to a healthier lifestyle! Be beautiful inside and out with Suzanne Somers Beauty, Health & Fitness! Find The Suzanne Somers Podcast - On YouTube, Facebook, Instagram, Apple Podcasts, Google Podcasts, Spotify, ROKU, and Apple TV and on The Range Broadcasting network.