Alzheimer's Disease (Audio)

Alzheimer's disease is a major health crisis that is projected to become an even larger threat in the coming decades. According to the National Institute on Aging, the number of Americans 65 and older with Alzheimer's could rise from 5.8 million in 2020 to 13.8 million by 2050. Given the severity of this health crisis and the toll it takes on patients, their families and society, we must be prepared today to address the needs of tomorrow. Dean Frank LaFerla of UC Irvine's School of Biological Sciences presents an overview of the state of Alzheimer's disease research. Following his presentation, the panel discusses emerging trends in research, care and the upcoming challenges we will face and how we might mitigate them. [Health and Medicine] [Show ID: 38660]

Thomas C. Südhof, M.D., Stanford University, discusses facets of the fundamental cell biology of ApoE and APP analyzed in stem cell-derived human neurons. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38405]

Dr. Songi Han, professor in the Department of Chemistry, Biochemistry and Chemical Engineering at UC Santa Barbara, talks about her research into the function of proteins in the body and how changes like protein Tau tangles can lead to neurological diseases like Alzheimer's. Series: "GRIT Talks" [Health and Medicine] [Science] [Show ID: 37869]

Tarek Rajji, MD, shares research from current trials combining brain stimulation with interventions including cognitive remediation. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 37598]

Dr. Georges Naasan discusses communication difficulties associated with the language syndrome of Alzheimer's Disease. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 37334]

Dr. Georges Naasan describes the symptoms seen in the frontal/executive syndrome of Alzheimer's disease. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 37335]

Research suggests that listening to or singing songs can provide emotional and behavioral benefits for people with Alzheimer's disease. Dr. Theresa Allison provides an overview of music in the context of dementia and caregiving relationships. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 37150]

Stem cell research is changing the way Alzheimer's disease is diagnosed and treated. Larry Goldstein, PhD and Doug Galasko, MD join Alysson Muotri, PhD to share the latest findings and what the future may hold. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36805]

Lawrence S.B. Goldstein, PhD discusses his career in science and his work to understand the molecular basis of neuronal defects in Alzheimer's Disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36338]

Researcher Alysson Muotri is using stem cells to study everything from autism to the Zika virus. In this excerpt Muotri discusses stem cell and brain organoid research for possible applications to human diseases. Series: "Health Matters" [Health and Medicine] [Show ID: 36301]

Interactive immune systems are at the center of cancer and other diseases. Dr. Matthew Krummel explores some lesser-known functions of the immune system related to memory making, arteriosclerosis, and gut health. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36205]

Dr. Aimee Kao discusses key behaviors known to protect brain health. Dr. Kao looks at population trends and wonders if they tell a complete story. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36154]

Dr. Aimee Kao looks at recent news in Alzheimer's Disease therapeutics including drugs in development and the potential of stem cells and genome editing. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 35238]

David M. Holtzman, MD of the Washington University School of Medicine discusses the mechanisms underlying neurodegeneration and how microglia and specific microglial genes such as TREM2 influence neurodegeneration in the setting of Aβ and tau pathology. Learn how this line of study may lead to new therapeutics and diagnostic testing for Alzheimer's disease. Series: "Brain Channel" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 35262]

Worldwide 50 million people live with dementia. By 2040 over 70% of them will be living in the developing world. Dr. Shamiel McFarlane explores the social and economic cost of dementia around the world. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 34779]

There are modifiable behaviors that may reduce the risk factor of Alzheimer's: vascular disease, sedentary lifestyle, depression/stress, diet factors and alcohol. Kaitlin Casaletto talks about the benefits of an active lifestyle and proper nutrition. Then Dr. Joanna Hellmuth looks at how to decode direct-to-consumer interventions - dietary supplements - and the rise of pseudo-medicine for dementia. She explains that supplements may or may not be safe and that manufacturers can make broad claims without supporting evidence. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 35136]

Dr. Julio Rojas-Martinez discusses the pharmacological treatment of Alzheimer’s disease now and what is in development. Current approaches pursue early intervention in the dementia phase. Novel emerging strategies will likely accompany anti-amyloid and anti-tau approaches in the future. Then Sarah Dulaney, RN, describe dementia education, support, and non-pharmacological treatment strategies. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 34777]

Alzheimer’s disease is the most common but not the only cause of dementia throughout the lifespan. Dr.Salvatore Spina discusses frontotemporal dementias and how they differ. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 34776]

Dr. Geroges Naasan explores the principal clinical syndromes of Alzheimer's Disease: memory, visual, language and frontal/executive. He also discusses neuropathology, genetic factors and modern biomarkers with colleagues from the UCSF Memory and Aging Center. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 34775]

Neurologist Dr. Serggio Lanata explores the neurodegenerative disease of the brain, what they have in common and how they differ. alzheimer's is the most common neurodegenerative disease but there are several others including Parkinson's, Huntington Disease and others. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 34774]

More than 5 million Americans are currently diagnosed with Alzheimer’s disease, and that number is expected to triple by 2050, without prevention or cure. By 2060, the number of Latinos in the United States living with Alzheimer’s disease is projected to increase 832 percent — from 379,000 in 2012, to more than 3.5 million. Find out what UC San Diego is doing to both serve this community and catalyze the research careers of investigators from underrepresented groups. Series: "Brain Channel" [Health and Medicine] [Show ID: 34417]

Alex Figueroa and Dr. Jose Soria-Lopez discuss clinical symptoms of Alzheimer's Disease and the need to include the Latino community in clinical research. Series: "Brain Channel" [Health and Medicine] [Science] [Spanish Language] [Show ID: 34416]

Este es el primer episodio en español de la Universidad de San Diego California sobre la investigación de la Enfermedad de Alzheimer Demencia en la comunidad latina. En este episodio Alex Figueroa y el Dr. Jose Soria-Lopez conversan sobre los síntomas clínicos y la necesidad de incluir la comunidad latina en investigaciones clínicas sobre esta enfermedad. Se mencionan maneras de combatir la enfermedad y recursos sociales que están disponibles para personas con esta enfermedad y familiares. Series: "Brain Channel" [Health and Medicine] [Science] [Spanish Language] [Show ID: 34205]

Rudolph Tanzi, PhD, of the Harvard Medical School describes a fundamental problem with modern-day treatment of Alzheimer's disease. Series: "Wellbeing " [Health and Medicine] [Show ID: 34243]

Dale Bredesen, MD, UCSF and UCLA, discusses how environmental toxins may lead to Alzheimers disease. Series: "UCSF Consortium for Obesity Assessment, Study and Treatment" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 34090]

There are different types of genetic influences on people's risk of developing Alzheimer's disease. Douglas Galasko, MD, of the UCSD Shiley-Marcos Alzheimer’s Disease Research Center joins William Mobley, MD, PhD to discuss these genes, how they are being studied, and what being a carrier of Alzheimer's associated genes means. Learn more about penetrance and expressivity, genome-wide association studies, and more. Series: "Brain Channel" [Health and Medicine] [Show ID: 33725]

How do you model a disease process that stretches out over 20 years in a way that helps you intervene in that process? In the inaugural Shiley Endowed Lecture, Bradley Hyman, MD, PhD shares his research on the progression of Alzheimer's disease. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 33992]