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HEALTH NEWS   Study links low vitamin C levels in the blood plasma to reduced brain connectivity Study: Tart Cherry Supplementation Alters Muscle Protein Profile After Exercise Socioeconomic factors may leave more lasting imprint on children's brains than IQ or parenting style Fasting-mimicking diet reduces gum disease inflammation Low blood pressure shows strongest link to Alzheimer's disease   Study links low vitamin C levels in the blood plasma to reduced brain connectivity Hirosaki University (Japan), June 10 2026 (News-Medical) Previous research has uncovered associations between diets higher in vitamin C and lower risk of cognitive impairment in older adults. However, few studies have looked directly at vitamin C levels in blood plasma and potential associations with brain structure and connectivity within brain networks. To help fill that gap, Nagaya and colleagues analyzed magnetic resonance imaging (MRI) scans and plasma vitamin C levels of 2,044 adults over the age of 64. Specifically, they measured the volume of each participant's gray and white brain matter (accounting for individual differences in total brain volume between participants). They also evaluated connectivity within the default mode network, which is associated with several cognitive functions, such as attention and autobiographical memory. After statistically accounting for other factors the researchers found that participants with lower plasma vitamin C levels tended to have lower gray matter volume, as well as lower connectivity within the default mode network. These findings suggest the possibility that optimal levels of vitamin C in blood plasma could potentially support cognitive function and counteract cognitive decline. However, the findings do not confirm any such cause-effect relationship between vitamin C levels and brain health.   Study: Tart Cherry Supplementation Alters Muscle Protein Profile After Exercise University of Exeter (UK), June 11 2026 (Natural News) Researchers recruited 34 healthy, recreationally active young men and assigned them to receive either a placebo, a low-dose tart cherry concentrate, or a high-dose tart cherry supplement, according to the study report. Participants consumed their assigned supplement for seven days before completing a muscle-damaging workout and continued supplementation for three days afterward, for a total intervention of 10 days. The study found that tart cherry supplementation significantly altered the muscle's protein profile following exercise-induced damage. Changes were observed in proteins involved in muscle structure, contraction, cellular repair processes, and immune-cell activity within muscle tissue. These findings suggest that tart cherry polyphenols may influence the way muscles respond to and recover from the stress of exercise. Researchers also detected significant increases in hippuric acid, a compound produced when gut microbes break down polyphenols from tart cherries and other plant foods. Participants with higher levels of hippuric acid tended to maintain better muscle function following exercise-induced damage.   Socioeconomic factors may leave more lasting imprint on children's brains than IQ or parenting style Washington University in St. Louis, June 11 2026 (Medical Xpress) After analyzing hundreds of biological, psychological, social and environmental factors related to children's development, researchers at Washington University School of Medicine in St. Louis found that a family's financial situation and the resources and opportunities in a child's neighborhood had the strongest connection to brain development. Socioeconomic factors accounted for about 16% of the variability in measures of children's brain function—far more than IQ, parenting style and health history.  As part of the study, the researchers analyzed brain scans from nearly 12,000 children ages 9 to 10 to see how a child's environment, health and regular activities are related to brain development. Of the hundreds of factors examined, the team found that the socioeconomic status of a child's family had the strongest relationship with that child's brain structure and function. Further, the parts of the brain that reflect socioeconomic factors were the same areas most sensitive to sleep and stress, suggesting that socioeconomic disadvantage affects the brain indirectly through disrupted sleep and chronic stress. Of the top 40 variables linked to brain function, 37 were socioeconomic, and of the top 40 tied to structure, 35 were socioeconomic. These included the social and economic resources in the child's neighborhood, akin to the overall wealth of an area. Strong influences included family income, homeownership, poverty rates and access to transportation. The remaining top variables were related to sleep, screen time and stress.   Fasting-mimicking diet reduces gum disease inflammation Kings College London, June 11 2026 (Eurekalert) People who follow a short-term low-calorie diet may have reduced markers of inflammation associated with gum disease. A new study by King's College London highlights how lifestyle modifications could be important alongside plaque control in managing gum disease. The research included 28 patients from across hospitals in Spain, split into two groups – those who followed a five-day restrictive diet, versus a control group who continued their usual diet. Patients who fasted ate 1,100 calories for two days, then 750 calories for three days. The sixth day gently introduced more calories with soft foods – then their diets returned to normal by the seventh day. This was repeated three times in six months, with patients reporting the diet easy to stick to. After six months, samples were analysed from the patients' blood and gingival crevicular fluid – liquid that comes from the small space between your tooth and gum, which helps gums stay healthy and fight germs. Those who fasted had reduced markers of inflammation in samples from blood and gum tissue compared to those whose diets stayed the same, including lower levels of C-reactive protein, a general indicator of inflammation around the body. The fasting group also had reduced molecules linked to inflammation specifically in the gums, compared to controls.   Low blood pressure shows strongest link to Alzheimer's disease Michigan Technological University, Jun 10 2026 (News-Medical) Numerous types of cardiovascular disease and CVD risk factors were linked to a higher risk of Alzheimer's disease, with low blood pressure showing the strongest connection, according to a new analysis published today in the Journal of the American Heart Association What are the key findings of the analysis? Adults with hypotension (low blood pressure) were about three times more likely to develop Alzheimer's and nearly twice as likely in the All of Us study when compared to individuals who did not have low blood pressure. Across both datasets, adults with high blood pressure (hypertension) were 1.6 times more likely to have Alzheimer's disease, compared to people without hypertension. Participants who had a previous stroke had a 1.5 times higher risk for Alzheimer's disease in the UK Biobank and 1.85 times in All of Us. Those with irregular heartbeat (or atrial fibrillation, also called AFib) were about 1.5 times more likely to have Alzheimer's disease compared to those without AFib.    

First up on the podcast, producer Kevin McLean talks with Staff Writer Paul Voosen about the latest on the Atlantic Meridional Overturning Circulation, or AMOC. Researchers have long been concerned that global warming could cause a collapse in the AMOC, which would trigger dramatic cooling in Northern Europe. But recent data and models suggest the AMOC may be more resilient than previously thought. Next on the show, Scott Marek, assistant professor in the Mallinckrodt Institute of Radiology at Washington University School of Medicine, talks with host Sarah Crespi about brainwide association studies (BWAS) for childhood brain development. BWAS measure structure and function across many brains and look for correlations between these measures and behavior, disease, and environment. In this work, Marek and colleagues focus on how socioeconomic factors—captured by zip code—are strongly correlated with certain brain differences in more than 4000 children ages 9.5 to 11. The work also suggests lack of sleep and excess screen time could mediate the influence of socioeconomic conditions on differences in brain structure and function. This week's episode was produced with help from Podigy. About the Science Podcast Photo: P. Voosen/Science Learn more about your ad choices. Visit megaphone.fm/adchoices

The American Democracy Minute Radio News Report & Podcast for June 5, 2026Unsigned SCOTUS Alabama Order May Make Intentional Discrimination Even Harder to Prove and Allow States to Ignore the Purcell PrincipleWe recently reported that the U.S. Supreme Court's majority greenlighted Alabama's return to its 2003 congressional district map, twice struck down by a lower court as intentionally discriminatory.  One election law expert calls it a “significant and very bad” decision. Some podcasting platforms strip out our links.  To read our resources and see the whole script of today's report, please go to our website at https://AmericanDemocracyMinute.orgToday's LinksArticles & Resources:U.S. Supreme Court - Order Allowing Alabama to use its discriminatory 2003 Map, overturning lower courtU.S. District Court (via ACLU) -  Decision affirming Alabama's 2003 congressional map was intentionally discriminatoryElection Law Blog - Professor Rick Hasen, UCLA Law School  - Breaking: The Supreme Court, Over the Dissent of the 3 Liberal Justices, Allows Alabama to Use Maps that a Lower Court Found to Be Intentionally Discriminating Against Black Voters (Now Updated with Analysis–This is a Significant and Very Bad Ruling)Election Law Blog - Professor Travis Crum, Washington University School of Law - The Supreme Court Rewards Alabama's Defiance Brennan Center for Justice - What the Supreme Court Gets Wrong About Democracy in the SouthRelated ADM Reports:American Democracy Minute -  The Purcell Principle, Often Used in the SCOTUS Shadow Docket, Will Be Argued in the Texas Gerrymandering Decision.  What is it?American Democracy Minute - U.S. Supreme Court Majority Greenlights Alabama's 2023 Congressional Map, After a Lower Court Panel Said -Again- It Intentionally DiscriminatedRegister or Check Your Voter Registration:U.S. Election Assistance Commission – How to Register And Vote in Your State Find all of our reports at AmericanDemocracyMinute.orgSubscribe for FREE at Apple Podcasts, Spotify and most podcasting platforms.#NewsAlerts #AmericanDemocracy #Alabama #USSupremeCourt #Milligan #RacialDiscrimination #ShadowDocket #VotingRightsAct

Listen to JCO's Art of Oncology article, "Indistinguishable from Magic" by Dr. Michael Slade, who is a medical oncologist at Washington University School of Medicine. The article is followed by an interview with Slade and host Dr. Mikkael Sekeres. Dr Slade shares the challenges of day-to-day clinical practice in oncology through the lens of speculative fiction and how we struggle, as physicians and as patients, to tell the difference between what we know and what we can only hope for. LINK TO FULL TRANSCRIPT

Send us Fan Mail**THIS IS A REPUBLISHING** Prior episode uploaded incorrectly and therefore no audio.  My apologies.  Please find the new upload fully operational.  Thanks for listening!There is a line from Carl Jung that has stayed with me for years: Until you make the unconscious conscious, it will direct your life and you will call it fate. Most of the things we try to change about our lives — the habits, the relationships, the version of ourselves we keep trying to become — we try to change them from the outside. More discipline. More systems. More willpower. And most of the time, it doesn't work for long. Today's episode is about the thing that has to happen before the change: the noticing. The Awareness Reset. Four movements drawn from the teaching lineage of Neville Goddard and Joel Goldsmith, supported by contemporary neuroscience, that walk you through awareness, belief, identity, and behavior — in the order that actually works. What we cover: • The gap Viktor Frankl pointed at — the space between stimulus and response, where your freedom lives • The Default Mode Network — what neuroscientists at Washington University discovered about the brain's "autopilot" setting, and why it is not you • Jordan Poppenk's 2020 research on "thought worms" — and the roughly 6,200 thought transitions the average mind moves through in a day • Jeffrey Schwartz's concept of attention density — why the stories you keep turning toward grow, and the ones you stop feeding atrophy • Why "I am" sentences carry more creative weight than "I will" sentences — Neville Goddard's foundational teaching, applied • The one small action practice — and why Donald Hebb's law runs in both directions Three quiet invitations, if today's episode landed for you: 1. The free live workshop. I'm hosting a free sixty-minute workshop on Thursday, May 21 at 7:00 PM ET where we walk through the Awareness Reset together in real time. [Save your spot here.]2. The companion workbook. A seventeen-page companion I wrote for this episode — teachings, practices, journaling space, and a seven-day integration plan. Free when you sign up for the email series, or available on its own. [Get the companion here.]3. 31 Days to New Beginnings. My signature course — a thirty-one-day guided walk through the full ReThink practice. For the person ready to actually live this. [Learn more.]Mentioned in this episode: • Carl Jung — Aion and various essays on the unconscious • Viktor Frankl — Man's Search for Meaning • Marcus Raichle — Default Mode Network research, Washington University School of Medicine • Jordan Poppenk & Julie Tseng — "thought worms" study, Queen's University / Nature Communications, 2020 • Donald Hebb — The Organization of Behavior, 1949 • Neville Goddard — The Power of Awareness, Feeling Is the Secret • Joel Goldsmith — The Infinite Way • Joe Dispenza — Breaking the Habit of Being Yourself • Jeffrey Schwartz — You Are Not Your Brain, UCLA research on self-directed neuroplasticity • William James — The Gospel of Relaxation  Connect: Website: rethinkpodcast.com Instagram: @ReThinkPodcast Listen everywhere you get your podcasts. New episodes every weekSupport the Podcast: https://www.buzzsprout.com/1590358/support Closing of ReThinkBuzzsprout - Let's get your podcast launched! Start for FREESupport the show

Send us Fan MailThere is a line from Carl Jung that has stayed with me for years: Until you make the unconscious conscious, it will direct your life and you will call it fate. Most of the things we try to change about our lives — the habits, the relationships, the version of ourselves we keep trying to become — we try to change them from the outside. More discipline. More systems. More willpower. And most of the time, it doesn't work for long. Today's episode is about the thing that has to happen before the change: the noticing. The Awareness Reset. Four movements drawn from the teaching lineage of Neville Goddard and Joel Goldsmith, supported by contemporary neuroscience, that walk you through awareness, belief, identity, and behavior — in the order that actually works. What we cover: • The gap Viktor Frankl pointed at — the space between stimulus and response, where your freedom lives • The Default Mode Network — what neuroscientists at Washington University discovered about the brain's "autopilot" setting, and why it is not you • Jordan Poppenk's 2020 research on "thought worms" — and the roughly 6,200 thought transitions the average mind moves through in a day • Jeffrey Schwartz's concept of attention density — why the stories you keep turning toward grow, and the ones you stop feeding atrophy • Why "I am" sentences carry more creative weight than "I will" sentences — Neville Goddard's foundational teaching, applied • The one small action practice — and why Donald Hebb's law runs in both directions Three quiet invitations, if today's episode landed for you: 1. The free live workshop. I'm hosting a free sixty-minute workshop on Thursday, May 21 at 7:00 PM ET where we walk through the Awareness Reset together in real time. [Save your spot here.]2. The companion workbook. A seventeen-page companion I wrote for this episode — teachings, practices, journaling space, and a seven-day integration plan. Free when you sign up for the email series, or available on its own. [Get the companion here.]3. 31 Days to New Beginnings. My signature course — a thirty-one-day guided walk through the full ReThink practice. For the person ready to actually live this. [Learn more.]Mentioned in this episode: • Carl Jung — Aion and various essays on the unconscious • Viktor Frankl — Man's Search for Meaning • Marcus Raichle — Default Mode Network research, Washington University School of Medicine • Jordan Poppenk & Julie Tseng — "thought worms" study, Queen's University / Nature Communications, 2020 • Donald Hebb — The Organization of Behavior, 1949 • Neville Goddard — The Power of Awareness, Feeling Is the Secret • Joel Goldsmith — The Infinite Way • Joe Dispenza — Breaking the Habit of Being Yourself • Jeffrey Schwartz — You Are Not Your Brain, UCLA research on self-directed neuroplasticity • William James — The Gospel of Relaxation  Connect: Website: rethinkpodcast.com Instagram: @ReThinkPodcast Listen everywhere you get your podcasts. New episodes every week. If this episode was useful, the kindest thing you can do is share it with one person who needs it today. Thank you for being here.Support the Podcast: https://www.buzzsprout.com/1590358/support Closing of ReThinkBuzzsprout - Let's get your podcast launched! Start for FREESupport the show

Welcome to another episode of the Peaceful Political Revolution in America podcast.In this episode, I will be exploring one of the most important and timely questions facing our country today: What would it look like if Americans were to rethink the Constitution?For a long time, the thought of holding a constitutional convention has been dismissed by most Americans, something debated by historians and legal scholars, perhaps, but rarely engaged in by ordinary citizens. Recently, that conversation has begun to emerge. Across the country, citizens are asking deeper questions about whether the political system we inherited is capable of meeting the challenges of the 21st century. Stephanie Lindquist serves as the Nickerson Dean and professor of law at Washington University School of Law.  She is also the founder of the Model Constitutional Convention.  In May 2026, in St. Louis, this groundbreaking initiative will bring together participants from more than 80 universities across the country. Modeled on the Article 5 process of the US Constitution, the convention is designed to simulate national deliberations over our most basic law.  Beyond these deliberations, there is a growing national conversation concerning real-world constitutional reform.  Organizations like Unify USA, Braver Angels, Better Together America,  CELDF, Alliance for Democracy, Citizens Take Action, and many more are drafting their own amendments, forming their own citizen assemblies, and considering the possibility of calling for a popular national convention. Thomas Jefferson once suggested that each generation should have the opportunity to reconsider the constitutional framework under which it lives. If that is true, this moment may represent an opportunity, especially for younger generations, to help shape what comes next.  The Model Constitutional Convention is an attempt to explore these questions in a serious, thoughtful, and constructive way. In this conversation, Stephanie Lindquist explains how the project began, how delegates will develop their proposals, what kinds of ideas are emerging, and how everyday Americans can follow along.Stefanie, it's a pleasure to have you on the Peaceful Political Revolution in America podcast. Welcome to the conversation.

Dr. Samuel Klein from the Washington University School of Medicine is researching a new GLP 3 weight-loss drug. He says his clinical trials are looking to recruit women who would like to be part of the trials that also include exercise classes. He warns that some Americans are getting the popular weight-loss drugs through the 'gray market' with no medical supervision. For more information on the clinical trials he's leading -- 314-273-1879 nutritionresearch@wustl.edu

Recent studies from the past week highlight new insights into Ozempic and similar GLP-1 medications for weight loss. Researchers from the University of Eastern Finland, Karolinska Institutet in Stockholm, and Griffith University in Australia analyzed large-scale data and found that semaglutide, the active ingredient in Ozempic, significantly reduces risks of depression, anxiety, and addiction alongside its weight loss effects. According to their work published in The Lancet Psychiatry, users experienced a 44 percent lower risk of depression and a 38 percent drop in anxiety disorders during treatment periods. Psychiatric hospital visits fell by 42 percent, and substance use disorders decreased by 47 percent compared to times without the medication. The team suggests these benefits may stem from lifestyle changes or direct effects on the brain.Another study from Washington University School of Medicine, reported by Fox News, warns that stopping GLP-1 drugs like Ozempic quickly erodes heart health gains. Continuous use over three years lowered cardiovascular risk by 18 percent through reductions in cholesterol, blood pressure, inflammation, and insulin resistance. However, quitting for six months raised risk by 4 percent, one year by 14 percent, and two years by 22 percent. Restarting the drugs provided partial protection, only 12 percent, indicating some lasting damage from discontinuation. Lead researcher Ziyad Al-Aly described this as metabolic whiplash, with silent reversals in metabolic health that could lead to heart attacks or strokes.Oprah Winfrey continues to draw attention for her weight loss transformation using GLP-1 medications. The List reports that recent before-and-after photos from events like the 2025 Tony Awards reveal Ozempic neck, a sagging, crepey skin effect under the jaw due to rapid fat loss outpacing skin adjustment. Winfrey has been seen favoring high-necked outfits to camouflage the loose folds, a common side effect among users.These developments underscore the dual-edged nature of Ozempic for weight management, offering mental and heart benefits during use but posing challenges with side effects and discontinuation.Thanks for tuning in, listeners, please subscribe, and remember, this episode was brought to you by Quiet Please podcast networks. For more content like this, please go to Quiet Please dot Ai. Come back next week for more.Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

A new Washington University School of Medicine study examines how the app, uMAT-R, improves recovery outcomes for people with a substance use disorder lacking stable housing. STLPR's Marissanne Lewis-Thompson digs in to why it's working.

A new study from the Cleveland Clinic, released this week, reveals that stopping weight-loss drugs like Ozempic and Mounjaro does not always lead to the rapid weight regain seen in earlier trials. Researchers analyzed nearly eight thousand patients who discontinued these injectable medications, known as GLP-one drugs, after using them for obesity or type two diabetes. Those treated for obesity lost an average of eight point four percent of their body weight before stopping and regained just zero point five percent after one year. For diabetes patients, the average loss was four point four percent before discontinuation, followed by an additional one point three percent loss over the next year. Many participants restarted the drugs, switched to alternatives, or turned to lifestyle changes like working with dietitians, helping them maintain or even improve their results. Hamlet Gasoyan, the lead researcher, noted that real-world flexibility in treatment plans explains why outcomes differ from strict clinical trials, where regain was over half the lost weight.However, another study from Washington University School of Medicine, also published this week, warns that halting these drugs can quickly erode heart health benefits. In tracking over three hundred thirty-three thousand veterans with type two diabetes, continuous three-year use reduced cardiovascular risks like heart attack and stroke by eighteen percent. Stopping for six months raised risk by four percent, one year by fourteen percent, and two years by twenty-two percent. Restarting offered partial protection at twelve percent reduction, but not full recovery. Researcher Ziad Al-Aly described this as metabolic whiplash, with rising cholesterol, blood pressure, and inflammation that silently builds danger.Oprah Winfrey, who has openly discussed her use of GLP-one medications for weight loss, continues to show visible effects in recent appearances. Photos from events like Paris Fashion Week earlier this year highlight what observers call Ozempic neck, loose skin under the jaw from rapid fat loss. Winfrey has favored high-neck outfits to address it, and some recent images suggest possible skin treatments are improving the appearance. She previously shared that the drugs made her feel more alive, stressing the need to start slowly to avoid side effects.These findings underscore the value of ongoing medical guidance for long-term success with Ozempic and similar drugs. Thanks for tuning in, listeners, please come back next week for more. Thanks for listening, please subscribe, and remember this episode was brought to you by Quiet Please podcast networks. For more content like this, please go to Quiet Please dot Ai.Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

On Jan. 22, the Trump Administration held a ceremony to launch the Board of Peace, a new international organization designed to implement peace in Gaza and other conflict areas.  Some have described the organization as President Donald Trump's alternative to the United Nations, which he has repeatedly criticized. So far, 24 countries have signed up, although none of the signatories are America's traditional allies. On Tuesday's "Sound of Ideas," we'll hear the latest installment of "Talking Foreign Policy," our quarterly series in collaboration with Case Western Reserve University, host Michael Scharf and a panel of experts discuss the implications of President Trump's Board of Peace. They'll also discuss how the current war with Iran impacts the mission of the Board of Peace. Does that conflict stand in contrast with President Trump's attempts at a global peace? Guests:- Michael Scharf, President, The American Branch of the International Law Association; Former Dean, Case Western Reserve University School of Law- Harold Hongju Koh, Professor & Former Dean of Yale School of Law; Former Assistant Secretary, The U.S. Department of State- Milena Sterio, Distinguished University Professor, Cleveland State University College of Law; Managing Director, The Public International Law & Policy Group- Leila Sadat, Professor, Washington University School of Law; Board Chair, The American Branch of the International Law Association- Jessica Peake, Director, The International and Comparative Law Program, UCLA School of Law

  We are closing out our miniseries where we pay tribute to one of my favorite podcasts, Revisionist History, hosted by the well-known author Malcolm Gladwell. Gladwell describes Revisionist History as a podcast about things overlooked and misunderstood. There are many injuries or problems we see in the office or on the sidelines that patients, parents, coaches, and even health care professionals give a generic label or diagnosis. In some situations, it may be correct, but often things get lumped into a simple category which may lead to things not being treated or managed most effectively. This is episode 11 of this series I am affectionately calling “Revisionist Sports Medicine”, a series about things in Pediatric Sports Medicine overlooked or misunderstood.   Connect with The Host! Subscribe to This Podcast Now!     The ultimate success for every podcaster – is FEEDBACK! Be sure to take just a few minutes to tell the hosts of this podcast what YOU think over at Apple Podcasts! It takes only a few minutes but helps the hosts of this program pave the way to future greatness! Not an Apple Podcasts user? No problem! Be sure to check out any of the other many growing podcast directories online to find this and many other podcasts via The Podcaster Matrix!     Housekeeping -- Get the whole story about Dr. Mark and his launch into this program, by listing to his "101" episode that'll get you educated, caught up and in tune with the Doctor that's in the podcast house! Listen Now! -- Interested in being a Guest on The Pediatric Sports Medicine Podcast? Connect with Mark today!     Links from this Episode: -- Dr. Mark Halstead: On the Web -- On X -- Dr. Jonathan Backus https://www.thesteadmanclinic.com/our-doctors/jonathon-d-backus -- AAOS Turf Toe https://orthoinfo.aaos.org/en/diseases--conditions/turf-toe/ -- Turf Toe Scottish Rite for Children https://scottishriteforchildren.org/what-is-turf-toe-7-faqs-about-this-common-sports-injury/ -- Turf Toe (Stat Pearls) https://www.ncbi.nlm.nih.gov/books/NBK507810/       Calls to the Audience Inside this Episode: -- Be sure to interact with the host, send detailed feedback via our customized form and connect via ALL of our social media platforms! Do that over here now! -- Interested in being a guest inside The Pediatric Sports Medicine Podcast with Dr. Mark? Tell us now! -- Ready to share your business, organization or efforts message with Dr. Mark's focused audience? Let's have a chat! -- Do you have feedback you'd like to share with Dr. Mark from this episode? Share YOUR perspective!   Be an Advertiser/Sponsor for This Program!   Tell Us What You Think! Feedback is the cornerstone and engine of all great podcast. Be sure to chime in with your thoughts, perspective sand more.  Share your insight and experiences with Dr. Mark by clicking here!   The Host of this Program: Mark Halstead:  Dr. Mark Halstead received his medical degree from the University of Wisconsin Medical School. He stayed at the University of Wisconsin for his pediatric residency, followed by a year as the chief resident. Following residency, he completed a pediatric and adult sports medicine fellowship at Vanderbilt University. He has been an elected member to the American Academy of Pediatrics (AAP) Council on Sports Medicine and Fitness and the Board of Directors of the American Medical Society for Sports Medicine (AMSSM). He has served as a team physician or medical consultant to numerous high schools, Vanderbilt University, Belmont University, Washington University, St. Louis Cardinals, St. Louis Blues, St. Louis Athletica, and St. Louis Rams. He serves and has served on many local, regional and national committees as an advisor for sports medicine and concussions. Dr. Halstead is a national recognized expert in sport-related concussions and pediatric sports medicine. — Dr. Mark Halstead on Facebook — Dr. Mark Halstead on LinkedIn — Dr. Mark Halstead on X — Learn Why The Pediatric Sports Medicine Podcast Exists...     Jonathan Backus:  Dr. Backus received his undergraduate degree at the University of Illinois and Kings College London Following his undergraduate education, he was awarded a Cancer Research Training Fellowship at the National Cancer Institute in Bethesda, MD. Dr. Backus then attended Duke University for medical school and completed a residency in Orthopaedic Surgery at Washington University School of Medicine. While in residency, he was selected as a resident scholar for the American Orthopaedic Foot and Ankle Society Annual meeting. Following residency, Dr. Backus completed a Foot and Ankle Fellowship at the Steadman Clinic. Prior to joining The Steadman Clinic surgical staff, he was an Assistant Professor at Washington University Orthopedics and previously in private practice in the Denver area. Dr. Backus was recognized by his peers as a Castle Connolly Top Doctors in the St. Louis area from 2021-2023. He has authored multiple peer reviewed articles and book chapters, taught on a national level, and serves on the American Orthopaedic Foot and Ankle Board of Directors. Connect with Dr. Jonathan Backus:  https://www.thesteadmanclinic.com/our-doctors/jonathon-d-backus    

This episode features Dr. Aayushi Uberoi PhD from Washington University in St. Louis (USA), speaking about the skin microbiome and various techniques for studying it. The skin is a reactive interface that protects the body, with the skin on various parts of the body looking very different because of stratifications in the epithelial layers and the local nutritional landscape. The skin microbiome in general is nutrient sparse and varies at different body sites. Research has shown that epithelial development, stratification, and differentiation are altered in the absence of the microbiota, showing the active role of the skin microbiota in regulating skin function. Microbes that inhabit the skin are shown to elicit unique immune responses with systemic effects. Communication between skin microbes and human body cells may be happening via metabolites. When conducting skin microbiome experiments, controls are important; the low biomass samples are susceptible to contamination. In the future, knowing more about the nutritional needs of the skin microbes could help guide the development of prebiotics for skin. Episode abbreviations and links: Paper showing a humanized mouse model for studying the skin microbiome: Commensal-derived tryptophan metabolites fortify the skin barrier: insights from a 50-species gnotobiotic model of human skin microbiome Paper on the skin microbiome's contributions to wound healing: The wound microbiota: microbial mechanisms of impaired wound healing and infection Paper investigating mechanisms of how skin microbes influence skin function: Commensal Microbiota Regulates Skin Barrier Function And Repair Via Signaling Through The Aryl Hydrocarbon Receptor Review by Belkaid and Segre: Dialogue between skin microbiota and immunity About Dr. Aayushi Uberoi PhD: Aayushi Uberoi is an Assistant professor of Pathology & Immunology and Medicine (Dermatology) in Washington University School of Medicine in Saint Louis. Her lab studies the host-microbe-environment interactions in regulating skin barrier. She has studied interactions between microbes and skin since her Ph.D. research on cutaneous papillomaviruses in Dr. Paul Lambert's lab at the University of Wisconsin-Madison. While traditional studies of infectious skin diseases have typically focused on singular pathogens within the host, skin is colonized by a diverse array of microbes, which likely exert significant influence on epithelial characteristics. Motivated by this question, Aayushi’s postdoctoral research at the University of Pennsylvania in Dr. Elizabeth Grice's lab explored the role of the commensal microbiome in regulating the function of the cutaneous barrier. In the lab, Aayushi wears several hats such as conducting research, developing protocols and assays, writing, and making sure the lab has fun equipment. Aayushi is a recipient of K99/R00 Pathway to Independence award from National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS/NIH), innovator award from Society of Investigative Dermatology, fellowships from Prevent Cancer Foundation and Dermatology Foundation and a Young Investigator Award from the Wound Healing Society. 

In this conversation on Compassion & Courage, Dr. Brian Bausano shares his journey to becoming an emergency medicine physician, highlighting the emotional challenges and the importance of teamwork and compassion in healthcare. He discusses the pivotal moments that shaped his career, the necessity of building a purpose-driven team, and the coping strategies that help healthcare professionals manage the emotional toll of their work. Dr. Bausano emphasizes the human element in patient care and the role of faith in providing comfort to patients during their most vulnerable moments. Join us in trying to keep clinicians in the field and taking care of themselves and others. Resources for you: More communication tips and resources for how to cultivate compassion: https://marcusengel.com/freeresources/Connect with Marcus on LinkedIn: https://www.linkedin.com/in/marcusengel/Connect with Dr. Brian Bausano on LinkedIn: https://www.linkedin.com/in/bbausanoLearn more about Marcus' Books: https://marcusengel.com/store/Subscribe to our podcast through Apple: https://bit.ly/MarcusEngelPodcastSubscribe to our podcast through YouTube: https://bit.ly/Youtube-MarcusEngelPodcast About Brian Bausano, MD, MBA:Brian Bausano, MD, MBA is a Professor of Emergency Medicine and Vice Chair of Clinical Affairs at Washington University School of Medicine, where he oversees clinical operations across six emergency departments serving more than 255,000 patients annually. With dual expertise in medicine and business—holding an MBA from Washington University's Olin Business School—he brings a unique lens to the intersection of operational excellence and patient-centered care. The first half of Brian's career was dedicated to educating an entire generation of emergency medicine physicians. He founded the Healthcare Administration Leadership & Management (HALM) Fellowship to develop the next generation of physician leaders and serves as Immediate Past President of the Missouri Chapter of the American College of Emergency Physicians. Everything Brian does is driven by a singular higher purpose: connecting people to their health, their happiness, and each other. His work proves that operational rigor and empathy aren't competing priorities but reinforcing ones—that building better systems is how we build better human connections. For Brian, emergency medicine isn't just about saving lives in critical moments; it's about creating environments where patients feel seen, teams feel supported, and compassion operates at scale. Date: 3/9/2026 Name of show: Compassion & Courage: Conversations in HealthcareEpisode number and title: Episode 179 – Building Purpose-Driven Teams in Healthcare with Brian Bausano, MD, MBA

Research just out shows new blood tests can now detect Alzheimer's-related changes years before symptoms begin. Dr. Suzanne Schindler says these findings help estimate how long that window may be. Once Alzheimer's-related changes begin to rise in the blood, “it creates kind of a clock for us,” Schindler, a clinical neurologist at Washington University School […] The post Alzheimer's: New Research on When Symptoms Start & Prevention appeared first on Healthy Communities Online.

Corey Then is the Vice President and Deputy General Counsel - Global Policy at Circle, a global financial technology company. He previously held a series of legal roles, and spent a period in the White House as an economics and Department of Justice lead. He's also an adjunct professor at the Washington University School of Law. We got to know eachother while Corey was in-house counsel at Moneta in St Louis. Our conversation starts with Corey's entry into law and how his stint in the White House was formative in terms of his approach to problem solving and working with teams. We move then to what interested him first in crypto assets and what brought him to Circle. Corey explains what it is about Stablecoins that makes them so transformational. He suggests that they will  enable commerce to speed up and that this increase in money velocity, will bring more prosperity to more people around the world..In terms of the risks to this trajectory, Corey suggests that if there are not comparable laws around the world, that StableCoin won't meet its full potential. He suggests that if there are balkanized regulatory structures around the world, we could end up with stable coins stopping at borders, which would be a huge disservice to consumers around the world. This podcast is kindly sponsored by Evanston Capital and Alvine Capital. For over 20 years Evanston Capital has had a key focus in identifying early-stage investment managers it believes are capable of generating long-term, value-added returns in complex, innovative strategy areas. Alvine Capital is a specialist investment manager and placement boutique with a particular focus on alternative assets with significant presence in London and Stockholm.

Dr Nancy L Bartlett from the Washington University School of Medicine, Dr John P Leonard from the Perlmutter Cancer Center, Dr Matthew Matasar from Rutgers Cancer Institute, Dr Loretta J Nastoupil from Southwest Oncology and Prof Pier Luigi Zinzani from the University of Bologna in Italy discuss recent updates on available and novel treatment strategies for follicular lymphoma and diffuse large B-cell lymphoma. CME information and select publications here.

At the time of this interview in 2021, Dr. Carrie Coughlin was an Assistant Professor of Dermatology at Washington University School of Medicine in St. Louis. She was also the Chair of the PeDRA Outcomes Committee, a member of the Meetings and Studies Committees, and led the Skin Tumors and Reactions to Cancer Therapies (STARC) Focused Study Group. Since then, she has become an Associate Professor of Dermatology and is serving as the Treasurer for PeDRA's Board of Directors. In this episode, Dr. Coughlin shares insights into her work, her leadership within PeDRA, and why effectively communicating pediatric dermatology research beyond the specialty is essential for advancing patient care and collaboration.Click here to listen to interviews with other PeDRA Board Members. Lastly, please fill out this anonymous 1-question survey.

Prof Claire Harrison from Guy's and St Thomas' NHS Foundation Trust in London, Dr Andrew T Kuykendall from Moffitt Cancer Center, Dr Stephen T Oh from the Washington University School of Medicine, Dr Jeanne Palmer from the Mayo Clinic School of Medicine and Dr Raajit K Rampal from Memorial Sloan Kettering Cancer Center discuss recent updates on available and novel treatment strategies for myelofibrosis and systemic mastocytosis.CME information and select publications here.

KMOX Health Editor Fred Bodimer talks about a recent flu surge across the country with Dr. Steven Lawrence, Professor of Medicine in the Division of Infectious Diseases at Washington University School of Medicine.

At the recent Make America Healthy Again, or MAHA, summit - which was attended by the U.S. Secretary of Health and the Vice President - the agenda showed a shift toward alternative medicine, wellness and nutrition and away from conventional medication. Most of the speakers were not academic researchers or doctors. To discuss what happens when government guidance moves away from scientific consensus, Miles Parks speaks with Dr. Sandro Galea, a Distinguished Professor in Public Health, and Dean of the Washington University School of Public Health in St Louis, Missouri.For sponsor-free episodes of Consider This, sign up for Consider This+ via Apple Podcasts or at plus.npr.org. Email us at considerthis@npr.org.This episode was produced by Avery Keatley and Jordan-Marie Smith. It was edited by Ahmad Damen. Our executive producer is Sami Yenigun. Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Send us a textIn today's episode of When Bearing Witness, we step into a conversation that sits at the heart of trauma-informed storytelling: what happens when a story intended to inspire instead causes harm, and how we move toward repair. Storytelling is powerful, but it is never neutral. When nonprofits share personal experiences without care, consent, or curiosity, those choices can leave deep emotional and relational wounds. This episode honors the truth that repair is possible, but only when we slow down enough to acknowledge harm and choose a different path forward.Joining me for this vulnerable and necessary conversation is Rachel D'Souza, the founder of Gladiator Consulting and a proud member of the Community-Centric Fundraising Global Council. Rachel's work centers on radical collaboration, racial equity, social justice, and decolonization, and her advocacy is deeply informed by her own lived experience of having her story misused for fundraising.We explore what accountability can look like, why harm repair matters, and how nonprofit storytellers can move toward practices rooted in dignity, agency, and healing.About Rachel D'SouzaRachel D'Souza, MPPA, MLS is the founder of Gladiator Consulting in St. Louis, MO, a boutique firm co-creating with nonprofits across the country. As a proud member of the Community-Centric Fundraising Global Council, Rachel works to guide and resource a global initiative to reimagine the nonprofit sector through a lens of radical collaboration, racial equity, social justice, and decolonization. In 2024, Rachel completed her coursework to earn her second Master's Degree at the Washington University School of Law. With this additional training in negotiation, mediation, and cross-cultural conflict resolution, Rachel is eager to shift organizational culture and interpersonal relationships in the direction of healing, collaboration, and systems change.Connect with Rachel D'SouzaGladiatorrds Website |  LinkedInAbout Host Maria Bryan Maria Bryan is a trauma-informed storytelling trainer. She helps nonprofit leaders tell powerful and impactful stories that resist harm. Maria has over fifteen years in marketing communications in the public sector. She has a Master's Degree in Public Administration, a Bachelor's Degree in Journalism, and is professionally certified in Trauma & Resilience, Trauma-Informed Space Holding, Trauma-Informed Coaching, and Somatic Embodiment & Regulation. Maria is a firm believer that storytellers make the world a healthier, safer, cleaner, and happier place. Connect with MariaSpeaking & Training | LinkedIn | Email

Dr. Leonard Weinstock discusses Innovative Solutions for Mast Cell Activation Syndrome with Dr. Ben Weitz.   [If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]    Podcast Highlights           Dr. Leonard Weinstock is Board Certified in Gastroenterology and Internal Medicine, practicing in St. Louis, Missouri.  He is president of Specialists in Gastroenterology and the Advanced Endoscopy Center.  He teaches at Barnes-Jewish Hospital and is an Associate Professor of Clinical Medicine and Surgery at Washington University School of Medicine. Dr. Weinstock is an active lecturer, including having spoken at some SIBO conferences, and he has published more than 70 articles, editorials, and book chapters.  He has teamed with Dr. Lawrence Afrin to research and publish articles on Mast Cell Activation syndrome and gastroenterology.  His contact info is at Specialists in Gastroenterology and his phone is 314-997-0554. Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.  

Dr Kathleen N Moore from OU Health Stephenson Cancer Center in Oklahoma City, Oklahoma, and Dr Matthew A Powell from the Washington University School of Medicine in St Louis, Missouri, discuss recent updates on available and novel treatment strategies for endometrial cancer. CME information and select publications here.

Send us a textHow mitochondria travel between cells and how this hidden communication shapes metabolism, immunity, and even potential therapies.Episode Summary: Dr. Jon Brestoff talks about mitochondrial dynamics inside cells, their transfer between unrelated cells (distinct from inheritance during division), and its roles in adipose tissue communication, macrophage cleanup, and systemic metabolic signaling; they explore how high-fat diets disrupt this process, potential hormetic benefits, therapeutic mitochondria transplantation for diseases like Leigh syndrome and obesity, and broader immunometabolism crosstalk.About the guest: Jon Brestoff, MD, PhD is an associate professor of pathology and immunology at Washington University School of Medicine in St. Louis, where he directs the Initiative for Immunometabolism.Discussion Points:Mitochondria per cell range from ~100-5000; they move via fusion/fission, vertical inheritance (cell division), or horizontal transfer without division.Transfer mechanisms: free release, extracellular vesicles, or tunneling nanotubes using cytoskeleton transport.In healthy fat tissue, adipocytes routinely donate mitochondria to macrophages for degradation (quality control); high-fat (lard-based, long-chain FA) diets block macrophage uptake, diverting mitochondria to other organs.Diverted mitochondria may induce “mito-hormesis” (mild oxidative stress boosting antioxidants) or signal adipocyte metabolic status inter-organ.Mitochondria transplantation shows promise in animal models for ischemia-reperfusion, obesity, and mitochondrial diseases.Immune cells prefer glycolysis but have low mitochondrial biomass; transplanted mitochondria tilt T-cells toward anti-inflammatory regulatory phenotype.Circulating cell-free mitochondria rival immune cell numbers.Obesity inflammation stems from dying oversized adipocytes releasing lipids/mitochondria, forming crown-like structures with pro-inflammatory macrophages.Leigh syndrome from genetic mutations disrupting the electron transport chain.Transfer may be an evolutionary relic of endosymbiosis; cells may selectively use exogenous mitochondria like a “generator” during metabolic crisis.Reference Paper:Study: The power and potential of mitochondria transferRelated Episode:M&M 260: Energy Resistance Principle in Life, Healing & Disease | Martin Picard & Nirosha MuruganSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Brad Young filling in for Mark Reardon talks with Scott Yenor, director of the B. Kenneth Simon Center for American Studies at the Heritage Foundation, to discuss the status of DEI across the country after a failed attempt by Washington University School of Medicine to evade accountability with its DEI office.

Interviewees: Matthew Sullivan, PhD, Assistant Director of Disability Resources, Washington University School of Medicine in St. Louis Suchita “Suchi” Rastogi, PhD. MPH Candidate, University of Illinois Chicago; CEO, Disability in Medicine Mutual Mentorship Program Interviewer: Lisa Meeks, PhD, MA, Guest Editor, Academic Medicine Supplement on Disability Inclusion in Undergraduate Medical Education Description: In this episode of Stories Behind the Science, Dr. Lisa Meeks talks with Matt Sullivan (Washington University School of Medicine) and Suchita “Suchi” Rastogi (UIC; DM3P) about their paper, “Standardized Language for Clinical Accommodations in U.S. Undergraduate Medical Training: Results From a National Modified Delphi Consensus Study,”part of the Academic Medicine supplement on Disability Inclusion in UME. Their conversation explores how a grassroots idea—born from students' lived experiences and practitioners' urgent need for clarity—grew into the first national, evidence-based language guide for clinical accommodations. Together, they unpack how a modified Delphi process brought students, Disability Resource Professionals, and leaders together to build consensus around the precise language that transforms intention into implementation. The trio discuss how language and word choices can make the difference between support and confusion, and how transparent, shared language strengthens trust and access for all. Dr. Meeks, Sullivan, and Rastogi also reflect on the collaborative model that made this project possible—one that centers disabled voices, encourages vulnerability in leadership, and demonstrates how clarity in communication is the foundation of equity. Listeners will come away with practical takeaways for institutions and leaders: audit your accommodation templates, build structured partnerships between DRPs and Student Affairs, and engage students as co-creators in designing accessible clinical environments. Transcript: https://docs.google.com/document/d/1ooJ5TP8V8s4t35EECoWHNTta7qqwbKlx-Fgu_WIiPG4/edit?usp=sharing Bios: Matt Sullivan PhD Dr. Sullivan is the Assistant Director of Disability Resources, At Washington University in St. Louis, and serves as DR's liaison to WashU's School of Medicine, acting as the primary contact for SoM faculty/staff, students, and prospective students.  In this role, Matt works closely with all parties to create an accessible and inclusive educational environment for disabled students pursuing their degrees within Health Sciences and Medicine. Dr. Sullivan is a research-oriented practitioner dedicated to promoting disability awareness and inclusion within the higher education environment.  In his student affairs roles, Dr. Sullivan has experience providing leadership and direction for a variety of programs and services in the areas of disability, testing, tutoring, Supplemental Instruction, and academic coaching.  Working in the field of disability services for more than a decade, Matt has dedicated his time and energy to the education and development of students, faculty, and staff surrounding the intersectionality of disability with race, culture, gender, and other prominent identity factors. Suchita “Suchi” Rastogi PhD Suchi is an MPH student at the University of Illinois Chicago and CEO of the Disability in Medicine Mutual Mentorship Program (DM3P). A former MD-PhD student at Stanford University, she advocates for accessible medical education and leads community-based efforts to promote disability inclusion and peer mentorship. As a South Asian disability activist, she values health equity and compassionately designed systems that serve all people with dignity. She believes everyone deserves respect, access to material resources, and psychosocial support. These values compel her to improve healthcare and public health infrastructure for disabled patients, increase disability representation in medicine, and shift attitudes towards persons with disability. To accomplish this, she 1) run a mentorship program (DM3P) for healthcare professionals with disability, 2) conducts disability health equity research, and 3) advocates for evidence-based policies that center accessibility. Key Words: Clinical accommodations · Disability inclusion · Medical students · Disability Resource Professionals ADA Resources: Article from Today's Talk: Dhanani Z, Rastogi S, Sullivan M, Betchkal R, Poullos P, Meeks LM. Standardized Language for Clinical Accommodations in U.S. Undergraduate Medical Training: Results From a National Modified Delphi Consensus Study.Academic Medicine. 2025;100(10S):S92–S97. DOI: 10.1097/ACM.0000000000006150 Read the full article here → Equal Access for Students with Disabilities: The Guide for Health Science and Professional Education (2nd Ed). Meeks LM, Jain NR, & Laird EP. Springer Publishing, 2020. Read here → The Docs With Disabilities Podcast: https://www.docswithdisabilities.org/docswithpodcast

Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common forms of muscular dystrophy, affecting individuals across the lifespan with variable severity. Advances in genetic understanding and therapeutic development have led to an era of promising disease-modifying strategies. In this episode, Katie Grouse, MD FAAN, speaks with Renatta N. Knox, MD, PhD, author of the article “Facioscapulohumeral Muscular Dystrophy” in the Continuum® October 2025 Muscle and Neuromuscular Junction Disorders issue. Dr. Grouse is a Continuum® Audio interviewer and a clinical assistant professor at the University of California San Francisco in San Francisco, California. Dr. Knox is an assistant professor of neurology in the Division of Pediatric Neurology and Neuromuscular Section at Washington University School of Medicine in St. Louis, Missouri. Additional Resources Read the article: Facioscapulohumeral Muscular Dystrophy Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN  Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Grouse: This is Dr Katie Grouse. Today I'm interviewing Dr Renatta Knox about her article on fascioscapulohumeral muscular dystrophy, which appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Welcome to the podcast, and please introduce yourself to our audience. Dr Knox: Hi Katie, thank you so much for the invitation for the audio interview. I'm looking forward to our conversation. As she mentioned, my name is Renata Knox. It's a pleasure to be here today. Dr Grouse: I'd like to start by asking, what is the key message that you hope your readers will take from your article? Dr Knox: I would say two things. The first is an appreciation and understanding of the unique genetic mechanism that leads to FSHD. And the second is the really exciting therapy landscape that we find ourselves in. So, we're hopeful that there will actually be disease-modifying therapies for FSHD soon. Dr Grouse: We're really looking forward to learning more about that. Now, before we get to that piece, could you just remind us of the clinical manifestations and features that are specific to FSHD? Dr Knox: So, one of the most unique things about FSHD that we see clinically is the pattern of weakness. So, one of the first features is that it's asymmetric. And then there are certain muscle groups that typically are affected, and that's partly where the name comes from. So, we see effects in the face, the limbs, the trunk; and so, those are some of the unique features that we see clinically. Dr Grouse: I'd love it if you could walk us through how you approach diagnosing a patient who presents with proximal weakness where FSHD is in your differential. Dr Knox: Yeah, it's a really great question. So, I would say it depends. So, I actually focus on FSHD in my clinical practice. So, many times patients are referred to me because there's a very high suspicion or there's a known family history of FSHD. So, that's one category of cases. I would say the other category of case is where it's, as you said, maybe more proximal weakness more broadly. Someone that's before me who has a known family history, they really have some of the characteristic physical features---which I'm pretty attuned to, as this is, you know, part of my subspecialty---I'll actually go directly to FSHD genetic testing. And that is one of the unique features of this disease, that the next-generation sequencing panels that are typically used for some of our other muscle diseases, FSHD is not captured on those. So, we actually have to send targeted testing for FSHD to diagnose it. So, that is one category where, again, I have a very high suspicion either based on their clinical presentation and/or a known family history, then I will actually go directly to FSHD-targeted genetic testing. In the second case, where it is one of the conditions that I'm considering among others, I will do more broad testing. So, I will get a CK level to see if there's evidence of muscle breakdown. I'll likely also do one of the next-generation sequencing panels that we have access to, which will allow us to identify, potentially, one to two hundred potential muscle diseases. And then again, if FSHD is higher on my differential in that second group of patients, then I will also send targeted FSHD-specific testing. Dr Grouse: That's really helpful. And I'm wondering if you have any thoughts about common pitfalls that you've seen when providers are trying to work this up? Dr Knox: I don't know if I would say pitfalls. I think I would acknowledge that it's challenging. My subspecialty training in neuromuscular medicine and also gene therapy. And so FSHD is pretty high on my radar. But I would say in neurology in general---and then, you know, the general medical population---,it really isn't something that many people are seeing. So, I would say what patients will communicate to us sometimes is some frustration that maybe it took time to make the diagnosis, but I just have a deep understanding that it's not something that is on many people's radars. And I think, again, it's tricky because it's not picked up on these next-generation sequencing panels, which many of us can send pretty easily. It will be missed. And I will say the biggest pitfall is, again, if you're not thinking about it and you don't send that testing, you actually- it's very difficult to diagnose it. Dr Grouse: Thank you so much for highlighting that. I think there are many people who are not aware that those different panels really aren't picking that up and that they have to test specifically. So, I think that's a great thing for all of us to keep in mind. Are there any tips or tricks to the diagnosis, other than the genetic issues that you mentioned, that sometimes can really bring this diagnosis to the forefront? Dr Knox: I think things that really tip me off to having a higher suspicion for FSHD is facial weakness that we can detect on our exam. Scapular winging---again, there's a small subset of disorders which can impact that. Someone who's presenting with foot drop, you know, with facial weakness, I think definitely about FSHD more. Also, clinically, kind of the presentation or things that they're beginning to have difficulty with is a tip-off. So, if someone is an athlete, like, they're a volleyball player or basketball player and they say, oh, I'm having difficulties, you know, with movements that require them to elevate their arm, which can be a sign of the shoulder weakness that we classically see. Or someone who says, oh, I'm having a harder time shampooing my hair or combing my hair. So those can be tip-offs again, which are basically referencing the type of weakness that they have. Another feature of FSHD which isn't necessarily as broadly appreciated is that pain and fatigue are very common. So, if someone is coming in and saying, actually, I also have a significant amount of fatigue as well or a lot of pain, that's something that can tip me off to it. Hearing loss is something that we can also see in up to 20% of patients with FSHD. So, if they are having those symptoms or saying they're ringing in their ears, these are some things that will make me begin to think about it more. Dr Grouse: Oh, really helpful. I also found it really fascinating reading some of the very FSHD-specific clinical signs, some interesting- some diagrams and pictures as well, that are very specific to the pattern of weakness that develops in FSHD. So, I encourage our listeners to check that out. But are there any highlights from those little clinical pearls that you'd like to point out? Dr Knox: I think the poly-hill sign---so, these are these literal hills that we can see in the shoulders of patients with FSHD---is pretty classic. Popeye arms, which is this older term that we still use that has to do with which muscle groups are preserved versus those that have atrophy. So that's a common feature. And then I would say, really, the asymmetry is something that is a unique feature in FSHD. And again, we did our best to provide good representative images. So again, as you mentioned, Katie, I would really encourage people to look at those images and then think about cases that they may have seen and how similar they are so they can begin to recognize those signs as well. Dr Grouse: Now going back to the genetic topic, the complex genetic underpinnings of FSHD are really well-explained in your article; and again, worth taking a look at to remind ourselves of everything that's of that pathology. Now, I was wondering though, if you could give us a brief overview of how we should approach genetic testing in a suspected case of FSHD? You mentioned some specific panels, but it does sound like there's some more complexity to it as well. Dr Knox: Yes, and I'll just kind of briefly explain that complexity. Part of the thing that we're detecting in the genetic testing is the repeat number. And so, we're actually looking for a contraction in a repeat number. So, not an expansion, which were typical for some of the diseases that we think about, the trinucleotide repeat disorders. And this is why it's not captured in the next-generation sequencing panels, because they do not currently have the ability to do that. And so, again, what the type of testing that I do really depends on my suspicion. So again, if my suspicion is very high for FSHD---they have a family history, they have the classic features---then I will actually go directly to an FSHD-specific testing, which is available from various sources. If, again, it's among different things that I'm thinking about, I will get a CK lab. I typically will also send a next-generation sequencing panel specific for muscle diseases, perhaps muscular dystrophy; again, depending on what I'm thinking about. And then I will also send in a specific FSHD genetic test as well. People are beginning to use whole-genome sequencing, which is capturing some of our true nucleotide repeat disorders and becoming more comprehensive. So, my hope is that as that becomes more standard of care---like, whole-exome sequencing can be gotten pretty routinely now---that it may be easier for us to make some of these diagnoses. Dr Grouse: Well, that's really helpful, and thanks for that overview. Now another thing that you mentioned that I thought was really interesting in your article was that patients with, you know, history of FSHD, perhaps in the family, who are pregnant and want to screen for this disease would not be able to use sort of the more common screening tests like cell-free DNA testing and may have to go to other means to do that. What is generally their route to this type of testing? Dr Knox: Yeah, great question, and really important question for family planning purposes, and it definitely comes up in clinical practice. And so again, because of the unique genetics of FSHD, you actually have to do invasive genetic testing currently to be able to test it. And so that's, you know, amnio or chorio, and then send it to a lab that can perform, again, FSHD-specific testing on the samples that are presented. And there are obviously labs that are capable of doing that and centers that are capable of doing that, but it is not picked up on the cell-free DNA panels that are being very routinely used. You or your provider has to be thinking about it to send that specific testing, similar to our patients that come into clinic and have not yet been diagnosed. Dr Grouse: Once you have the diagnosis, what are our options for therapy? I think it sounds like at this current time, it looks to be mostly supportive. What are some of the supportive care options we should keep in mind? Dr Knox: Yes, so that is definitely accurate. Care today is supportive, but again, we're very excited about the clinical trial and therapy landscape for FSHD. So, I work very closely with my physical therapy colleagues that are in clinic with me. So, we work very closely with physical and occupational therapists to help with supportive measures, adaptive measures, doing assessments, helping our patients to be able to move and exercise safely and effectively. As I mentioned, pain is very common in FSHD and so we can treat that with medications. The most common medication that we use to treat for pain in FSHD are NSAIDs. And then other than that it's really, you know, supportive measures. Do they need to see other subspecialists? There are some surgical options. Those are used very rarely to help with some of the scapular weakness, but typically it's physical therapy, occupational therapy, supportive devices. We treat the pain as we're able to, and then we work with other subspecialists to screen, monitor and support our patients to the best of our ability. Dr Grouse: Well, without further ado, I'd love to hear more about what's coming down the pipeline in clinical trials. What can we look forward to seeing, hopefully, in future years to treat these patients? Dr Knox: Yes. And so, this is actually what got me interested in the neuromuscle space in general is that, because we now for many years have known the genetic cause of many of these disorders as well as some of the underlying mechanisms, we can actually use advances in therapeutics to do what we call targeted therapies. So, rather than treating symptoms or indirect methods or doing kind of broad drug screens---which, again, still do take place and still do have their place---we actually can target mechanisms directly. And so, we know that the underlying biology of FSHD is due to this protein called DUX4 being expressed when it should not be. So, it's what we call a toxic gain of function. And so, the targeted way to address this is to suppress DUX4 expression. And so, kind of broadly speaking, what we're really excited about are a couple of products that are currently in clinical trials right now that actually caused DUX4 suppression to be suppressed. And again, these are targeted pathways. And so, again, the hope is that by doing that, we can hopefully slow the progression of the disease, potentially stop progression of the disease, and potentially reverse. Again, we don't know if that might be possible, but that is one of the hopes. Dr Grouse: Well, that's really exciting, and I know we're all looking forward to more coming down the pipeline soon, and hopefully more things that can really offer some exciting treatments for our patients with this condition. Now, a little more deep-dive into our patients who are diagnosed. You've reviewed some of the treatments currently available and hopefully may someday soon be available. Are there other things that we should be keeping in mind in this population? For instance, screenings that we should be doing for other extramuscular manifestations that we need to be thinking about? Dr Knox: I will answer that question two ways. I think something that's very important to acknowledge is the impact that these diagnoses and these conditions have on our patient practically, psychologically. One of the other unique features of FSHD is, it's autosomal-dominant. So, if it is in a family, you can have many family members who are affected, but the variability is very high. And so, you can have in the same family someone who is wheelchair-dependent, and someone else in the family with the same underlying genetics who has no signs or symptoms or is very mildly affected. And that is something that is definitely challenging for our families and patients to navigate if they're very different than their family members with the same condition. And just navigating the world with a condition that, you know, can be physically debilitating and cause changes to what they're able to do or not able to do, progression is something that's very difficult to handle. So, I think that's one set of things. And we try our best, you know, with my team and my other colleagues in the space, to support our families and patients in the best way that we can. Secondly, there is very important screening that needs to be done for this condition. So, one of the things- and the current guidelines which are actually being updated, the last update was in 2015 is all patients that undergo pulmonary function testing or PFTs. And so that's something we do at baseline and we do at least annually in my practice. Young kids who are presenting very early or patients with certain genetics that we know are more predisposed to extra muscular manifestations, we recommend screening for hearing, which is one of the manifestations, and ophthalmologic exam to look for retinovascular changes, which is one of the manifestations as well. Those are the more common ones that are typically done. There's also some evidence in pediatric patients with very severe manifestations that there may be some cognitive impacts, learning impacts. And so, that is something we're also thinking about screening and supporting our patients in that way. And again, we typically work with these patients in a multidisciplinary team depending on what manifestations and the degrees to which they're impacted by the disorder. Dr Grouse: Thank you so much for that answer. I think a lot of us forget sometimes when we get really focused on what can we do now, that we forget to kind of stop and reflect on sort of the more holistic approach. How is this affecting the patient? How is this affecting the patient's family dynamic, and what other ways are they going through life with this condition that we need to be thinking about? So, I appreciate you bringing that up. I wanted to ask, sort of based on what you're talking about and what you mentioned already, you happened to mention that what initially drew you that to this work was your interest in some of the really exciting breakthroughs in the field. Well, was there anything else that drew you to, specifically, congenital neuromuscular diseases, and FSHD in particular? Dr Knox: I'm a physician scientist by training, and so I would describe myself also as a molecular biologist. So, I love getting into the nitty gritties of disease mechanisms, what genes are doing in bodies, how they function. And so, as I mentioned earlier, in the neuromuscle space, we've known for many years the genetic cause of many of these disorders and have done great, you know, mechanistic work to kind of define why we see the disease. And then now we're at this intersection of that knowledge marrying with these really novel therapeutic approaches, gene therapy approaches, being able to intersect and then in very creative ways actually target diseases very directly. And so, I would say it really is the combination of those two things. FSHD has a really fascinating unique biology, which again, we encourage everyone to read about more in the article. That really drew me to it. I'm very interested in gene regulation, transcription. This is one of the underlying mechanisms that is gone awry in the disorder, and then that being married to advances in therapeutics. So, you could wed those two pieces of information and actually meaningfully impact patient 's lives. And again, that's the real privilege and honor to witness is how these therapies can transform lives. And I saw it happened with this one case for this one disorder when I was a resident where there was no treatment. Young children, unfortunately, would not survive the disease. And then I saw the therapy come be in development and literally change the trajectory. And this is what we're very hopeful for in the FSHD space, that wedding, this wonderful basic science research, translational research, companies working together to develop these therapies that can transform lives. It is just so beautiful to witness and see, and it's something that I get to do. You know, it's a part of my job, so it's a real privilege. Dr Grouse: Well, I have to say, it's really inspiring hearing you talk about it. And I imagine that many neurologists-in-training who are listening to this may be inspired as well and may be convinced to go into this field for that very reason. So, thank you so much for sharing all of this information with us today. I learned a lot, and I think all of our listeners have too. Dr Knox: Thank you. It's really been a pleasure. Dr Grouse: Again, today I've been interviewing Dr Renatta Knox about her article on fascioscapulohumeral muscular dystrophy, which appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Be sure to check out Continuum Audio episodes from this and other issues. And thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Dr. Greg Cejas, an autism specialist and researcher in the department of psychiatry at Washington University School of Medicine and Megan Lynch, discuss the varying factors that play a part in children developing autism.

Bienvenidos a la quinta temporada de Pediatras en Línea, un podcast creado para conectar a profesionales de la salud con experiencias, herramientas y modelos innovadores que están transformando el cuidado pediátrico en nuestras comunidades. Hoy tenemos un episodio dirigido a ustedes: pediatras, médicos de atención primaria, residentes y profesionales que trabajan con pacientes pediátricos hispanohablantes.  Nos acompañan dos cirujanos pediatras de Children's Hospital Colorado que lideran una iniciativa única en su tipo: una clínica de cirugía pediátrica completamente en español. Conoceremos cómo funciona este modelo, su impacto en la atención, y cómo puede servir como inspiración para replicarlo en otros sistemas de salud. El Dr. José Luis Díaz-Mirón es originario de Nuevo Laredo, Tamaulipas, México. Estudió medicina en Baylor College of Medicine, en Houston, Texas y completó su residencia en cirugía general en Washington University School of Medicine, en San Luis, Missouri. La especialidad en cirugía pediátrica la realizó en la Universidad de Michigan, Ann Arbor. El Dr. Jonathan Hills-Dunlap estudió en la escuela de medicina de la Universidad de Stanford. Cuenta con una maestría en salud pública de la Escuela de Salud Pública de Harvard. Su residencia la cursó en Brigham and Women's Hospital y en la Escuela de Medicina de Harvard. Realizó un fellowship de Investigación en Servicios de Salud Pediátrica de Harvard en el Boston Children's Hospital y la subespecialidad de Cirugía Pediátrica en el Children's Hospital Colorado en la Universidad de Colorado. Actualmente ambos trabajan en Children's Hospital Colorado donde han desarrollado la primera clínica en el estado de Colorado para pacientes de habla hispana. Clínica de cirugía pediátrica de habla hispana . Click or tap if you trust this link." id="OWA0ed31062-1cc1-9dc2-f276-b96e9f292da1" href="Clínica de cirugía pediátrica de habla hispana ">Clínica de Cirugía Pediátrica | Children's Hospital Colorado (Children's Hospital Colorado ) ¿Tienes algún comentario sobre este episodio o sugerencias de temas para un futuro podcast?  Escríbenos a pediatrasenlinea@childrenscolorado.org.

Professor Matthew Kreuter, Kahn Family Professor of Public Health at the Washington University School of Public Health, joins Megan Lynch following an annual poll of St Louisans about their health concerns. He says the gun violence ranking stays high, but is decreasing as mental health concerns are climbing.

In today's data-driven healthcare landscape, integrating diverse data sources into dynamic dashboards is transforming how organizations identify market opportunities and optimize provider deployment. Join us as we explore a compelling case study from Washington University School of Medicine, showcasing how Power BI dashboards are used to drive strategic decisions, improve access to care, and ensure financial sustainability.

The National Constitution Center and the Center on the Structural Constitution at Texas A&M University School of Law present a U.S. Supreme Court review symposium featuring leading constitutional law scholars and commentators analyzing the Court's most significant rulings of the term. Panel 1: Supreme Court Term Review Jonathan Adler, Tazewell Taylor Professor of Law, William & Mary Law SchoolDaniel Epps, professor of law, Washington University School of LawSarah Isgur, editor, SCOTUSblog; legal analyst, ABC NewsFrederick Lawrence, distinguished lecturer, Georgetown University Law CenterModerator: Katherine Mims Crocker, professor of law, Texas A&M University School of Law Stay Connected and Learn More Questions or comments about the show? Email us at ⁠podcast@constitutioncenter.org⁠ Continue the conversation by following us on social media @ConstitutionCtr. ⁠Sign up⁠ to receive Constitution Weekly, our email roundup of constitutional news and debate. Follow, rate, and review wherever you listen. Join us for an upcoming ⁠live program⁠ or watch recordings on ⁠YouTube⁠. Support our important work. ⁠Donate

On April 10, 2025, Ilya Shapiro, Senior Fellow at the Manhattan Institute and author of Lawless: The Miseducation of America's Elites, visited Washington University School of Law to discuss the ideological and bureaucratic challenges facing American higher education. In this lecture, Shapiro argues that elite universities have abandoned their core mission of truth-seeking in favor of activism, driven by bloated administrations and timid leadership. Drawing on personal experience and national trends, he explains how law schools, in particular, are failing to uphold classical liberal values such as free speech, academic freedom, and equal justice. Watch a video recording of the event: https://youtu.be/TGOmu2Ab-ZM The event was hosted by the Show-Me Institute, the Federalist Society, the Sinquefield Charitable Foundation, and Show-Me Opportunity.

Once the most popular graft choice for ACL reconstruction surgery, hamstring autograft has recently fallen out of favor for a variety of concerns including a higher graft rupture rate in younger athletes and concerns over graft diameters that tend to run smaller. However, what does the best level evidence actually say about hamstring autograft's long-term performance versus the current gold-standard, patellar tendon autograft? Dr. Derrick Knapick, MD joins us from Washington University School of Medicine in St. Louis to discuss his study looking at this question.    

Dr. Christopher Ray is a vascular neurologist at Washington University School of Medicine. He joins KMOX Health Editor Fred Bodimer with details on a new study focusing on acute migraines. Photo by Alamy/PA Images/Alamy Images/Sipa USA)

President Trump says the U.S. government is poised to accept an airplane from Qatar valued at nearly $400 million. He claims the 747 aircraft will replace the 40-year-old Air Force One. But the announcement has raised ethical and national security concerns. Geoff Bennett discussed more with Kathleen Clark, a government ethics expert and professor at Washington University School of Law. PBS News is supported by - https://www.pbs.org/newshour/about/funders

President Trump says the U.S. government is poised to accept an airplane from Qatar valued at nearly $400 million. He claims the 747 aircraft will replace the 40-year-old Air Force One. But the announcement has raised ethical and national security concerns. Geoff Bennett discussed more with Kathleen Clark, a government ethics expert and professor at Washington University School of Law. PBS News is supported by - https://www.pbs.org/newshour/about/funders

Since American president Donald Trump was elected to a second term, it is common to hear citizens, journalists, and public officials distinguish between the laws and leaders of their states and the national government. Those who oppose Trump's policies with regard to reproductive rights, gun violence, LGBTQ+, education, police, and voting often present state constitutions, courts, laws, culture, and leaders as a bulwark against Trump's autocratic rule.  But Professor Stephen H. Legomsky sees it differently. His new book, Reimagining the American Union: The Case for Abolishing State Government (Cambridge University Press 2025) argues that – if we care about democracy – we should imagine an America without state government. No longer a union of arbitrarily constructed states, the country would become a union of one American people. Reimagining the American Union understands state government as the root cause of the gravest threats to American democracy. While some of those threats are baked into the Constitution, the book argues that others are the product of state legislatures abusing their powers through gerrymanders, voter suppression, and other less-publicized manipulations that often target African-Americans and other minority voters. Reimagining the American Union interrogates how having national, state and local legislative bodies, taxation, bureaucracy, and regulation wastes taxpayer money and burdens the citizenry. After assessing the supposed benefits of state government, Professor Legomsky argues for a new, unitary American republic with only national and local governments. Stephen H. Legomsky is the John S. Lehmann University Professor Emeritus at the Washington University School of Law. Professor Legomsky has published scholarly books on immigration and refugee law, courts, and constitutional law. He served in the Obama Administration as Chief Counsel of U.S. Citizenship and Immigration Services and later as Senior Counselor to Secretary of Homeland Security Jeh Johnson. He was a member of President-Elect Biden's transition team, has testified often before Congress, and has worked with state, local, UN, and foreign governments. Mentioned: Cambridge University press is offering a 20% discount here (until October) Susan's NBN interview with Richard Kreitner on Break It Up: Secession, Division, and The Secret History of America's Imperfect Union Jonathan A. Rodden's Why Cities Lose: The Deep Roots of the Urban-Rural Political Divide (Basic Books 2019) Hendrik Hertzberg's review of Robert A. Dahl's How Democratic Is the American Constitution (Yale) Shelby County v. Holder, the Supreme Court case that overturned the Voting Rights Act of 1965's pre-clearance requirement for historically discriminating districts Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Since American president Donald Trump was elected to a second term, it is common to hear citizens, journalists, and public officials distinguish between the laws and leaders of their states and the national government. Those who oppose Trump's policies with regard to reproductive rights, gun violence, LGBTQ+, education, police, and voting often present state constitutions, courts, laws, culture, and leaders as a bulwark against Trump's autocratic rule.  But Professor Stephen H. Legomsky sees it differently. His new book, Reimagining the American Union: The Case for Abolishing State Government (Cambridge University Press 2025) argues that – if we care about democracy – we should imagine an America without state government. No longer a union of arbitrarily constructed states, the country would become a union of one American people. Reimagining the American Union understands state government as the root cause of the gravest threats to American democracy. While some of those threats are baked into the Constitution, the book argues that others are the product of state legislatures abusing their powers through gerrymanders, voter suppression, and other less-publicized manipulations that often target African-Americans and other minority voters. Reimagining the American Union interrogates how having national, state and local legislative bodies, taxation, bureaucracy, and regulation wastes taxpayer money and burdens the citizenry. After assessing the supposed benefits of state government, Professor Legomsky argues for a new, unitary American republic with only national and local governments. Stephen H. Legomsky is the John S. Lehmann University Professor Emeritus at the Washington University School of Law. Professor Legomsky has published scholarly books on immigration and refugee law, courts, and constitutional law. He served in the Obama Administration as Chief Counsel of U.S. Citizenship and Immigration Services and later as Senior Counselor to Secretary of Homeland Security Jeh Johnson. He was a member of President-Elect Biden's transition team, has testified often before Congress, and has worked with state, local, UN, and foreign governments. Mentioned: Cambridge University press is offering a 20% discount here (until October) Susan's NBN interview with Richard Kreitner on Break It Up: Secession, Division, and The Secret History of America's Imperfect Union Jonathan A. Rodden's Why Cities Lose: The Deep Roots of the Urban-Rural Political Divide (Basic Books 2019) Hendrik Hertzberg's review of Robert A. Dahl's How Democratic Is the American Constitution (Yale) Shelby County v. Holder, the Supreme Court case that overturned the Voting Rights Act of 1965's pre-clearance requirement for historically discriminating districts Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/political-science

Since American president Donald Trump was elected to a second term, it is common to hear citizens, journalists, and public officials distinguish between the laws and leaders of their states and the national government. Those who oppose Trump's policies with regard to reproductive rights, gun violence, LGBTQ+, education, police, and voting often present state constitutions, courts, laws, culture, and leaders as a bulwark against Trump's autocratic rule.  But Professor Stephen H. Legomsky sees it differently. His new book, Reimagining the American Union: The Case for Abolishing State Government (Cambridge University Press 2025) argues that – if we care about democracy – we should imagine an America without state government. No longer a union of arbitrarily constructed states, the country would become a union of one American people. Reimagining the American Union understands state government as the root cause of the gravest threats to American democracy. While some of those threats are baked into the Constitution, the book argues that others are the product of state legislatures abusing their powers through gerrymanders, voter suppression, and other less-publicized manipulations that often target African-Americans and other minority voters. Reimagining the American Union interrogates how having national, state and local legislative bodies, taxation, bureaucracy, and regulation wastes taxpayer money and burdens the citizenry. After assessing the supposed benefits of state government, Professor Legomsky argues for a new, unitary American republic with only national and local governments. Stephen H. Legomsky is the John S. Lehmann University Professor Emeritus at the Washington University School of Law. Professor Legomsky has published scholarly books on immigration and refugee law, courts, and constitutional law. He served in the Obama Administration as Chief Counsel of U.S. Citizenship and Immigration Services and later as Senior Counselor to Secretary of Homeland Security Jeh Johnson. He was a member of President-Elect Biden's transition team, has testified often before Congress, and has worked with state, local, UN, and foreign governments. Mentioned: Cambridge University press is offering a 20% discount here (until October) Susan's NBN interview with Richard Kreitner on Break It Up: Secession, Division, and The Secret History of America's Imperfect Union Jonathan A. Rodden's Why Cities Lose: The Deep Roots of the Urban-Rural Political Divide (Basic Books 2019) Hendrik Hertzberg's review of Robert A. Dahl's How Democratic Is the American Constitution (Yale) Shelby County v. Holder, the Supreme Court case that overturned the Voting Rights Act of 1965's pre-clearance requirement for historically discriminating districts Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/american-studies

This week on Breaking Battlegrounds, Congressman Mike Simpson of Idaho joins the show for a wide-ranging conversation that begins with his shocking discovery of the scale of missing and murdered Indigenous women—over 6,000 annually—and how Congress is finally taking action on justice and jurisdictional reform. He also breaks down the future of nuclear power, America's path to energy independence, and the urgent need to end our reliance on hostile nations for critical minerals and pharmaceuticals. Then, Newsweek's Josh Hammer returns to discuss his new book Israel and Civilization, where he argues that Israel—and the Jewish people—are the West's first line of defense against rising global threats. He also tackles the disturbing surge of anti-Semitism on college campuses, exposes the failures of higher education, and calls for revoking tax-exempt status for elite universities like Harvard. Don't miss Kiley's Corner, where she dives into the chilling mystery of 11 dead women found in New England over the last 60 days—is it the work of a serial killer or 11 separate psychopaths? Tune in now!www.breakingbattlegrounds.voteTwitter: www.twitter.com/Breaking_BattleFacebook: www.facebook.com/breakingbattlegroundsInstagram: www.instagram.com/breakingbattlegroundsLinkedIn: www.linkedin.com/company/breakingbattlegroundsTruth Social: https://truthsocial.com/@breakingbattlegroundsShow sponsors:Invest Yrefy - investyrefy.com4Freedom MobileExperience true freedom with 4Freedom Mobile, the exclusive provider offering nationwide coverage on all three major US networks (Verizon, AT&T, and T-Mobile) with just one SIM card. Our service not only connects you but also shields you from data collection by network operators, social media platforms, government agencies, and more.Use code ‘Battleground' to get your first month for $9 and save $10 a month every month after.Learn more at: 4FreedomMobile.comDot VoteWith a .VOTE website, you ensure your political campaign stands out among the competition while simplifying how you reach voters.Learn more at: dotvote.voteAbout our guest:An Idaho native, Mike Simpson was born in Burley and raised in Blackfoot. Mike graduated from Utah State University and earned his DMD from Washington University School of Dental Medicine in St. Louis, Missouri. After graduation, Mike joined his father and uncle at the Simpson Family Dental Practice in Blackfoot before serving in the Blackfoot City Council and State Legislature.Mike's political career began in 1980, when he was elected to the Blackfoot City Council. In 1984, he was elected to the Idaho Legislature where he served until 1998, the last six years serving as Speaker. Mike is currently serving his fourteenth term in the House of Representatives for Idaho's Second Congressional District.Mike serves as Chairman of the House Interior and Environment Subcommittee on Appropriations. His position gives him the unique opportunity to fight for Idaho's priorities and ensure Idahoans' hard-earned tax dollars come back to Idaho instead of going to states like New York or California.Mike also serves on the House Energy and Water Development Subcommittee and the Labor, Health and Human Services, Education Subcommittee on Appropriations. The committees Mike serves on have jurisdiction over funding for several agencies and programs critical to Idaho, including the Department of Energy, the Department of the Interior, the Forest Service, the National Parks Service, the National Endowment for the Arts, the Smithsonian Institute, and the Department of Labor.Mike and his wife Kathy have been married for 50 years and have called Idaho home all their lives. The two enjoy spending time with their poodle, Charley, and enjoying Idaho's beautiful scenery.-Josh Hammer is a friend of the show and the senior editor-at-large at Newsweek. He's the host of The Josh Hammer Show and the author of a new book, Israel and Civilization: The Fate of the Jewish Nation and the Destiny of the West, which recently reached as high as No. 3 on all of Amazon. You can follow him on X @josh_hammer. Get full access to Breaking Battlegrounds at breakingbattlegrounds.substack.com/subscribe

The topic of belonging and why it is so crucial to a healthy and high-functioning work environment within academic medicine is explored this week on the Faculty Factory Podcast with our esteemed return guest, Rakhee K. Bhayani, MD. Dr. Bhayani first joined our program in April 2022 for an episode covering career changes/pivots, identifying your purpose, and stepping outside of your comfort zone. You can revisit that discussion here: https://facultyfactory.org/rakhee-bhayani. She serves as Professor of Medicine and is the Vice Chair for Advancing Women's Careers in the Division of General Medicine and Geriatrics in the Department of Medicine at Washington University School of Medicine in St. Louis. "If we come to work and we have to specifically hide a part of who we are, that's mental energy and a tax that we're taking away from the work that we're doing,” she said. We welcome her back with open arms this week for an important and timely conversation on belonging's role in academic medicine and workplace culture. "Our goal is to help others feel comfortable and have that sense of safety, allowing them to bring their whole selves to work. This way, they can focus their energy on their work rather than expending mental energy on censoring parts of themselves to feel valued,” she added. Keep The Conversation Going Are you new to our show? Here are some similar Faculty Factory Podcasts to explore: Building a Sense of Belonging: A Faculty Factory Reunion with Heather Brod Identity Integration and Bringing Our Best Selves to Work with Jennifer Best, MD You can also find the full back catalog of the Faculty Factory Podcast here.  For feedback, questions, comments, and more information on how you can join the Faculty Factory as a guest, please visit our contact us homepage.

Traditional career development frameworks often overlook the importance of well-being. This podcast episode emphasizes why wellness is essential to building a sustainable and fulfilling career. Host Kyle Enfield, MD, FCCM, is joined by Jennifer Duncan, MD, and Raquel Cabral, PhD, CPH, to explore how team members and leaders can integrate personal values, connection, and purpose into career decision-making. Dr. Duncan, director of wellness for graduate medical education (GME), and Dr. Cabral, a staff psychologist for GME, both at Washington University School of Medicine, share insights from their work supporting trainees' personal and professional growth. Together, they explore the nuanced meaning of well-being—not as constant happiness, but as a sense of satisfaction and alignment with a person's values, even amid challenges. The conversation highlights the importance of helping team members identify and live by their personal values as a foundation for career satisfaction. Dr. Cabral distinguishes between goals and values, underscoring that, while goals can be achieved or not, values guide how a person shows up in all aspects of life. She outlines how residents and other early-career professionals can uncover values by reflecting on meaningful or difficult work experiences. These reflections can then guide decisions about clinical rotations, job searches, and leadership opportunities. Dr. Duncan emphasizes how small but intentional adjustments—such as carving out just 20% of one's time for personally meaningful work—can protect against burnout. Both guests discuss the critical role leaders play in supporting well-being, from understanding each team members' values to fostering a strong sense of community. They refer to The Burnout Challenge (Maslach C, Leiter MP. Harvard University Press. 2024), which outlines six workplace drivers of burnout, including mismatches in values. Finally, the episode highlights the work of the Mayo Clinic's Colleagues Meeting to Promote and Sustain Satisfaction (COMPASS) Groups. The COMPASS randomized clinical trial (West CP, et al. Mayo Clin Proc. 2021;96:2606-2614) evaluated a small group established to promote well-being. The group was provided discussion topics without trained facilitators. Protected time was not provided but meal expenses were compensated. This model showed positive outcomes in reducing burnout and strengthening collegial connections. This episode is part of SCCM's Leadership, Empowerment, and Development (LEAD) series and offers actionable insights for anyone invested in building healthier, value-aligned medical careers.

  Lisa Gitelson - The Fresh Air Fund: Because a Summer Can Last a Lifetime. This is episode 756 of Teaching Learning Leading K12, an audio podcast. Lisa Gitelson is the CEO of The Fresh Air Fund. Each year the nearly 148-year-old nonprofit invites about 3,000 low-income New York City-based children ages 8-18 to spend the summer swimming, rowing, hiking, and stargazing in Fresh Air Fund camps. Throughout Lisa's career in public service, as an attorney and child welfare advocate, she has been dedicated to addressing the needs of underserved youth.  Prior to joining The Fund, she was Assistant Executive Director/Legal Counsel for The New York Society for the Prevention of Cruelty to Children (NYSPCC). She is also an Adjunct Professor at Silberman School of Social Work, Hunter College, CUNY, where she teaches the Policy & Practice of Child Welfare.  As Assistant Executive Director/Legal Counsel for NYSPCC, Lisa identified legislation and other public policy issues that impacted the organization's work and developed an advocacy agenda to move public policy efforts forward.  Previously, she served as Associate Executive Director, Downstate, at the Council of Family and Child Caring Agencies (COFCCA) where she was responsible for bringing private foster care, juvenile justice, residential care and prevention services agencies together to coordinate advocacy efforts for the child welfare and juvenile justice systems. In this role, Lisa represented COFCCA member agencies in discussions with the Administration for Children's Services, the New York City Council and the New York State Office of Children and Family Services.    Prior to COFCCA, Lisa was the Director of Foster Care and Adoption Services at Sheltering Arms Children and Family Services. She began her career as an attorney representing foster care agencies before serving in multiple leadership and supervisory roles at the New York City Administration for Children's Services, Family Court Legal Services. Lisa is a graduate of Colgate University and has a JD from Washington University School of Law. Our focus today is The Fresh Air Fund. Awesome talk! So much to learn! Please share. Before you go... You could help support this podcast by Buying Me A Coffee. Not really buying me something to drink but clicking on the link on my home page at https://stevenmiletto.com for Buy Me a Coffee or by going to this link Buy Me a Coffee. This would allow you to donate to help the show address the costs associated with producing the podcast from upgrading gear to the fees associated with producing the show. That would be cool. Thanks for thinking about it.  Hey, I've got another favor...could you share the podcast with one of your friends, colleagues, and family members? Hmmm? What do you think? Thank you! You are AWESOME! Connect & Learn More: https://freshair.org/ https://x.com/FreshAirFund https://www.instagram.com/thefreshairfund/?hl=en https://www.facebook.com/freshairfund LGitelson@freshair.org Length - 32:10

Morgan had not turned 45 yet, so she hadn't received a screening colonoscopy for colorectal cancer. But when she noticed blood in her stool at age 41, she did exactly what she should have and sought medical evaluation. After months of missteps became years of dismissive care, she realized it was time for a second opinion at Siteman Cancer Center. With the help of WashU Medicine radiation oncologist Hyun Kim, MD, co-director of the Young-Onset Colorectal Cancer Program, Morgan was given a treatment plan that provided the care she needed. In this episode, we discuss her persistence and dedication to getting herself the best care for her young-onset colorectal cancer diagnosis.   “This is Cancer” is brought to you by Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis, and produced at Spot Content Studio in St. Louis, MO.   For more information on topics discussed in this episode, go to: https://siteman.wustl.edu/treatment/cancer-types/colorectal/young-onset-colorectal-cancer-program/ https://siteman.wustl.edu/treatment/cancer-types/colorectal/prevention-and-screening/  https://siteman.wustl.edu/doctor/kim-hyun/ https://getscreenednow.com/colon-cancer/ https://getscreenednow.com/insurance/  

Black pediatric patients believed to have neurological conditions are falling through the cracks. A new study finds that just half of Black patients completed the necessary genetic tests for diagnosis and treatment. St. Louis Public Radio's Marissanne Lewis-Thompson spoke with Dr. Christina Gurnett, co-author of the Washington University School of Medicine study highlighting the barriers Black families face accessing care.

“I went to law school at age 49 at Washington University School of Law, which is an Ivy League-level law school. I graduated with a 4.0, the highest GPA in my class. When people ask me how I did that while doing all this other stuff at the same time, I like to joke and say ‘I cheated.' At Orientation they told us we should spend four hours per class per week preparing for lectures. I spent eight hours preparing. Most people say, that's not cheating. Yes, but nobody does it. If you want to be the smartest person in the room, you have to be the most prepared person in the room. See, there's nothing extra-ordinary about me. I was a below average student in high school. I just start with the conviction that failure is not an option and I cannot be outworked. Then I move on to: ‘I'm going to out prepare everyone.' You see, the harder you work, the luckier you get.” Stephen Nalley is the owner and Managing Partner of Black Briar Advisors, which is a Small Business Administration and Veteran's Affairs Certified-Disabled Service-Connected Veteran-Owned Company. He has owned and operated over 200 hotels across the United States and has managed over $2 billion in Hotel & Resort Assets. He is the author of "Relentless Pursuit," where he describes the secret to success as knowing what you want and having a compelling reason why and the discipline to sacrifice what we want right now for what we really want later.

Dr. Jonathan (Jony) Kipnis is a BJC Investigator and the Alan A. and Edith L. Wolff Distinguished Professor of Pathology and Immunology at Washington University School of Medicine in St. Louis. He is also Professor of Neurology, Neuroscience, and Neurosurgery and Director of the Brain Immunology and Glia Center there. Jony is a neuroimmunologist. He works at the intersection of the immune system and the nervous system. The brain controls immune system activity, and the immune system affects brain function. The two work together to ensure our survival and well-being. Jony's research is improving our understanding of how they interact when we're healthy and in cases of nervous system damage or disease. When he's not working, Jony loves to read a good book, enjoy a nice glass of wine, cook, and eat delicious food. He particularly has a passion for grilling. He completed his BSc in Biology at Tel Aviv University, and he received his MSc in Neurobiology and PhD in Neuroimmunology from the Weizmann Institute of Science in Israel. Jony worked on the faculty at the University of Virginia for over a decade before joining the faculty at Washington University in St. Louis. He has received numerous awards and honors, including an NIH/NIA MERIT Award, the NIH Director's Pioneer Award, the Harrison Foundation Distinguished Teaching Professorship in Neuroscience, a Gutenberg Research College fellowship from the Johannes Gutenberg University of Mainz, and the Distinguished Research Career Development Award from the University of Virginia. He is also a Member of the National Academy of Medicine. In this interview, Jony shares more about his life and science.