Podcasts about Neurodegeneration

Dr. Hoffman continues his conversation with Neil Levin, the Senior Nutrition Education Manager and a product formulator for NOW(r) Foods and Protocol for Life Balance. 

Nutritional Support for Brain Health: Lifestyle, Curcumin, Magnesium, and Key Nootropics: Nutrition educator/formulator Neil Levin from Protocol for Life Balance details nutritional support for brain health amid skepticism about “brain-boosting” supplements, citing a preprint randomized controlled trial using a multifaceted lifestyle plan (diet, exercise, sleep) plus targeted supplementation that reportedly improved and even reversed symptoms in people with mild cognitive impairment. They contrast lifestyle strategies with costly, side-effect-prone injectable “plaque-buster” Alzheimer's drugs and notes debate about whether amyloid is a root cause or byproduct. The conversation highlights inflammation and oxidation as major aging-related brain threats and reviews supplements including a brain-targeted curcumin (discussing bioavailability, delivery methods, blood–brain barrier crossing, and claims of lowering beta-amyloid protein), magnesium L-threonate for CNS delivery, phosphatidylserine and acetylcholine support (including huperzine), ginkgo and gotu kola, glutamine/GABA pathways, creatine, omega-3s (DHA/EPA and algae sources), B vitamins, acetyl-L-carnitine, alpha-lipoic acid, and cocoa flavanols, plus concerns about supplement industry enforcement.

The doctors detail real-world results for cardiovascular disease, neurodegeneration, Lyme, and cancer using non-invasive therapies. #ChronicDisease #NaturalMedicine #HealingProtocols

Your daily coffee or tea may be helping your brain, not just your energy levels — new research links moderate intake to better cognitive health and aging. The findings add to growing evidence that simple daily habits can help support brain health over time. Guest host David Kirton is joined by Dr. Howard Chertkow, Leading Research Scientist at Baycrest and Scientific Director of the Canadian Consortium on Neurodegeneration in Aging to talk about what is being discovered.

In our second episode of the BRAIN (Black Researchers Addressing Inequalities in Neuroscience) podcast miniseries, we explore the lab techniques and interdisciplinary approaches being leveraged to understand how vascular health impacts neurodegeneration, particularly in underrepresented populations. Our guest is Cellas Hayes, a neuroepidemiologist and postdoctoral researcher at Stanford University School of Medicine (CA, USA), whose work traverses brain aging, Alzheimer's disease and vascular health, with a particular focus on blood-based biomarkers, white matter disease and cognitive aging across diverse populations. Using large, deeply phenotyped cohorts, Cellas studies how different modifiable and cardiometabolic risk factors shape brain health long before clinical dementia emerges. Beyond research, Cellas is strongly engaged in mentorship, grant writing and building equitable pathways in aging and neuroscience research. Hosted on Acast. See acast.com/privacy for more information.

Host: Yuval Zabar, MD Guest: Michelle Mielke, PhD Guest: Henrik Zetterberg, MD, PhD For the latest insights on tau and neurodegeneration biomarkers in Alzheimer's disease (AD), tune in to this recorded presentation featuring Doctor Michelle Mielke and Professor Henrik Zetterberg. Together, they delve into the role of tau in AD, exploring the ‘tau cascade', the current use of tau and neurodegeneration biomarkers in tracking disease progression, and how the AD biomarker landscape may evolve over time. Doctor Mielke is a Professor of Epidemiology and Neurology at the Wake Forest University School of Medicine, and Professor Zetterberg is a Professor of Neurochemistry at the University of Gothenburg. To learn more about tau in Alzheimer's disease, explore the Know Tau medical education platform. Know Tau is created and funded by Biogen and is intended for healthcare professionals only.

Roughly 90% of Alzheimer's patients develop neuropsychiatric symptoms including anxiety, persistent fear, and an inability to recognize safety — but little research is being done to investigate why. New data connecting PTSD, trauma, and accelerated brain aging may hold the answer.Dr. Caesar Hernandez is a behavioral, molecular, and circuit neuroscientist and assistant professor in the Division of Gerontology, Geriatrics & Palliative Care at the University of Alabama at Birmingham. His research program seeks to identify modifiable mechanisms that drive vulnerability to age-related cognitive decline and Alzheimer's disease.In this conversation with Dr. Dominic D'Agostino, Dr. Hernandez walks through epidemiological evidence linking PTSD to increased Alzheimer's risk, the comorbidity cluster of metabolic syndrome, gut permeability, and neuropsychiatric disorders observed in veteran populations, and why ketogenic interventions may offer a unique therapeutic angle — reducing neuroinflammation and anxiety while making the brain more receptive to rewiring traumatic memories.Questions Answered in This Episode: Could addressing PTSD in midlife meaningfully reduce the risk of cognitive decline and dementia later in life?Why do veteran populations show such high comorbidity between PTSD, metabolic syndrome, and dementia? Could ketogenic therapy serve a similar function to pharmacologically-assisted psychotherapy for PTSD? How does the amygdala - the brain's "fear center" - play a role in Alzheimer's disease? What is the single biggest unanswered question driving Alzheimer's research right now — and why does it go beyond genetics and biochemistry?Dr. Hernandez's driving question — why are negative life experiences associated with an increased the risk of neurodegeneration? — reframes brain aging as something shaped not just by genes and biology, but by the lives we live and the stress we carry.Find more of Dr. Caesar Hernandez online:University of Alabama BirminghamLinkedInSpecial thanks to the sponsors of this episode:✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here.✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK here.✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here.✅ ZocDoc - Find and instantly book a top-rated doctor here.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Accelerated brain ageing is a key feature of epilepsy that cannot be explained by seizures alone. Drawing on longitudinal imaging and biomarker research, Dr. Marian Galovic discusses neurodegeneration beyond seizure activity and the clinical importance of early intervention. This episode is sponsored by EASEE® by Precisis and had no influence over the editorial content or discussion. Learn more about EASEE® here: https://precisis.de/en  

How is advanced genetic engineering, stem cell biology, and AI-driven analytics reshaping the future of brain repair? Dr. Ruslan Rust, an Assistant Professor of Research Physiology and Neuroscience at the Keck School of Medicine of USC, joins the podcast to share his insights… With over 15 years of translational neuroscience research, Dr. Rust is developing next-generation gene-edited, induced pluripotent stem cell (iPSC)-derived therapies designed to overcome the biggest barriers in cell therapy — crossing the blood-brain barrier, immune rejection, and long-term safety. Dive in now to find out: Why current stem cell therapies struggle in stroke and neurodegenerative disease. Where stem cells are harvested.  How gene-edited iPSC-derived cells are engineered to cross the blood-brain barrier. The role of AI and single-cell omics in optimizing brain repair strategies. With additional training in MBA, bio-entrepreneurship, and scientific leadership, Dr. Rust brings a uniquely pragmatic lens to what it actually takes to turn cutting-edge neuroscience into viable therapies. Listen now for a rare look at how stroke recovery and Alzheimer's treatment may move from experimental promise to real clinical impact. You can keep up with Ruslan on X or by visiting his USC academic website!

Since debunking an urban legend that headbutting animals don't damage their brain, Nicole Ackermans has been investigating how the behavior correlates with neurodegeneration.

Send us a textCellular metabolism, mitochondrial health, and the roles of diet and environment in metabolic health, fetal & child development, and Alzheimer's.TOPICS DISCUSSED:Cellular growth vs. burning: Cells alternate between growing (using glucose for building blocks in low-oxygen environments) and burning (generating ATP in mitochondria with oxygen); dysregulation leads to metabolic issues.Key regulatory enzymes: PI3 kinase imports glucose, AMP kinase builds mitochondria, and mTOR drives cell division; their synchronization determines healthy modes, while desynchronization causes diseases.Fructose as a dose-dependent mitochondrial toxin: High fructose intake inhibits AMP kinase, reducing mitochondrial function and diverting energy to fat storage; it is dose-dependent, like alcohol, and unnecessary in the diet.Obesogens & endocrine disruptors: Chemicals like tributyltin (TBT) alter gene expression across generations, promoting obesity unrelated to calories; modern exposures increase reactive oxygen species (ROS), burdening cells.Fetal & neonatal development: Maternal diet, especially high sugar or formula feeding, can cause neonatal obesity and fatty liver; breastfeeding supports proper jaw development and oxygen intake.Brain metabolism & Alzheimer's: The brain's high energy needs make it vulnerable to mitochondrial issues and ROS; energy deficits from diet, stress, and toxins lead to synapse loss and inflammation, treatable via prevention.ROS & health: Mitochondria produce ROS as a byproduct of ATP generation; excess from diet or environment causes damage, but antioxidants and lifestyle can mitigate risks.PRACTICAL TAKEAWAYS:Limit added sugars in your diet to reduce mitochondrial stress and ROS, focusing on whole foods over ultra-processed items for better metabolic health.Prioritize breastfeeding for infants when possible to support proper physical development and reduce future metabolic risks.Incorporate regular exercise and social activities to manage stress and boost brain-protective factors like BDNF, aiding neurodegeneration prevention.Get adequate sleep to regulate cortisol and maintain cellular energy balance, helping prevent brain fog and chronic diseases.ABOUT THE GUEST: Robert Lustig, MD is a pediatric endocrinologist and Professor Emeritus at the University of California, San Francisco, with a background in neuroendocrinology and obesity research.*Not medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

FOREVER Digital Storage - Their mission is to be the complete, permanent, and safe place where millions of families save and enjoy their memories for generations. Please support this sponsor of the podcast.In this episode, we speak with Mark Burnett, founder of My Brain Restore™, about his personal battle with Parkinson's and early Alzheimer's — and the controversial path that followed. My Brain RestoreBurnett discusses:* His diagnoses and the moment he realized standard treatment offered no path to recovery* Why he turned to Japanese neurological research overlooked in Western medicine* The development of his proprietary processing method and why he believes it matters* What he can measure, what he cannot yet prove, and where critics are right to be skeptical* The ethical risks of self-experimentation when the alternative is slow decline* Why FDA limitations complicate public conversations about neurological recoveryThis is not a promotional interview. It is a rigorous, good-faith examination of claims, evidence, and uncertainty, designed to let listeners decide for themselves where they land.Topics Covered:* Parkinson's disease* Alzheimer's disease* Neurodegeneration and brain plasticity* Supplements vs. pharmaceuticals* Evidence standards and clinical trials* FDA regulation and medical claims* Patient-driven innovationImportant Disclaimer:This episode is for informational purposes only and does not constitute medical advice. Always consult licensed medical professionals before making health decisions. Get full access to Melvin E. Edwards at storiesfromreallife.substack.com/subscribe

As families gather over the holidays, many Canadians will be spending a lot of time with their parents and grandparents, sometimes for the only time all year. Dr. Howard Chertkow, Canadian research scientist at Baycrest Health Sciences and partner with the Canadian Consortium on Neurodegeneration in Aging (CCNA), joins Brent to talk about what signs you can look for and how families can approach the sensitive conversation.

For decades, Alzheimer's research has focused on clearing amyloid plaques from the brain. But new drugs that successfully remove plaques have proven clinically "underwhelming", leaving the field searching for alternative approaches.Stanford neurologist Katrin Andreasson has spent twenty years pursuing a different path—investigating how aging triggers an energy crisis in the brain's immune and support cells. Her work reveals that inflammation and metabolic dysfunction in microglia and astrocytes may be the real drivers of Alzheimer's pathology. Most remarkably, her recent research—supported by the Knight Initiative for Brain Resilience here at the Wu Tsai Neurosciences Institute—shows that targeting inflammation in the peripheral immune system—outside the brain entirely—can restore memory in mouse models of the disease. While human trials are still needed, Andreasson's findings offer fresh hope and demonstrate the critical importance of supporting curiosity-driven science, even when it challenges prevailing dogma.Learn More:Alzheimer's Association honors Katrin AndreassonResearch links age-related inflammation, microglia and Alzheimer's DiseaseQ&A: How the aging immune system impacts brain healthRethinking Alzheimer's: Could it begin outside the brain?Why new Alzheimer's drugs may not work for patientsParkinson's comes in many forms. New biomarkers may explain why.Send us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. We want to hear from your neurons! Email us at at neuronspodcast@stanford.edu Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

The tiniest parts of the cell may provide new insights into challenging neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). New research from Northwestern University has revealed a key mechanism underlying the development of motor neuron diseases, such as ALS, offering new insights into potential treatment options. This new finding published in the Journal of Neuroscience, comes from the lab of Vladimir Gelfand, PhD, and may help inform the treatment of ALS and other motor neuron diseases. 

Visit ⁠⁠⁠https://longevitybuilders.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠to discover book and The Longevity Builder Health Lab.Episode SummaryFor decades, the standard medical advice for cancer patients was simple: "Rest. Take it easy. Avoid exertion." Today's guest has spent her career proving that advice is not just outdated—it is dangerous.In this episode, Shane Stubbs sits down with Dr. Kathryn Schmitz, the world's leading authority in Exercise Oncology. Dr. Schmitz is the scientist who literally wrote the book on moving through cancer. She spearheaded the "Exercise is Medicine" initiative and has led over $30 million in research funding to prove that exercise changes the biology of cancer.We dive deep into why building a resilient body is your best defense, the specific "Move, Lift, Eat, Sleep, Log" framework, and how resistance training impacts survivorship.PLUS: Stay tuned until the very end for a "Science Spotlight" Bonus Segment. Shane breaks down new research highlighted by Dr. Rhonda Patrick on "Shear Stress"—explaining the physics of how vigorous exercise can mechanically destroy circulating tumor cells and reverse heart aging by 20 years.The Paradigm Shift: Why the old advice to "rest" during cancer treatment is being replaced by a prescription for movement.The Science: Dr. Schmitz's $30M+ research journey and her role in writing the ACSM guidelines for cancer survivors.The Protocol: The "Move, Lift, Eat, Sleep, Log" framework for building a body that can withstand the "Big Four" (Cancer, Heart Disease, Metabolic Dysfunction, Neurodegeneration).Exercise as Medicine: How specific doses of activity can alleviate symptoms, improve chemotherapy tolerance, and boost survival rates.BONUS Segment: The physics of Shear Stress. We discuss Dr. Rhonda Patrick's breakdown of how high-intensity blood flow can kill Circulating Tumor Cells (CTCs) and scrub your arteries.Dr. Kathryn Schmitz is a Distinguished Professor of Public Health Sciences and a Professor of Physical Medicine and Rehabilitation. A trailblazer in the field of Exercise Oncology, she served as the President of the American College of Sports Medicine (ACSM) and founded the Moving Through Cancer initiative.With a PhD in Exercise Physiology, an MPH in Epidemiology, and over 300 peer-reviewed scientific papers, Dr. Schmitz is the foremost voice on the intersection of movement and malignancy. She is the author of the book Moving Through Cancer.Book: Moving Through Cancer by Dr. Kathryn SchmitzInitiative: Moving Through Cancer (ACSM)Research Spotlight: Dr. Rhonda Patrick on Shear Stress & Circulating Tumor CellsReady to put this science into practice? Don't just listen—execute.Join the Longevity Builder Health Lab to access the protocols, community, and tools you need to build a body that lasts.

Molecular biologist Judith Frydman studies the nuances of protein folding and how defects in the process lead to neurodegenerative diseases. Her team studies protein folding in human cells and in model organisms, like yeast and worms, to understand the molecular events that precipitate harmful protein defects in humans. In one example, Frydman's team explored how aging affects the creation and the quality of proteins in the brain, leading to cognitive problems. She is now looking to develop therapies – someday perhaps leading to cures – to debilitating diseases such as Alzheimer's, Parkinson's, Huntington's, ALS, and others. The power of science gives her true hope in these important pursuits, Frydman tells host Russ Altman in this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: ​​Judith FrydmanConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Judith Frydman, a professor of biology and genetics at Stanford University.(00:04:00) Linking Protein Folding to AgingHow aging disrupts protein-folding machinery across many organisms.(00:07:16) Universal Aging PatternsThe similar age-related protein-folding defects found across organisms(00:09:27) Studying Killifish AgeingResearch on the African killifish as a rapid-aging model organism.(00:13:05) Ribosome Function DeclinesHow aging causes ribosomes to stall and collide, creating faulty proteins.(00:15:31) Aging Across SpeciesThe potential factors causing alternate aging rates in different species.(20:11) What Fails Inside Aging CellsThe cellular components that are leading to bad protein creation.(00:24:04) Therapeutic ApproachesPotential interventions to combat cellular and neurological degeneration.(00:25:12) Gene vs. Small-Molecule TreatmentsHow some interventions may be better suited for certain diseases.(00:27:47) Ribosome Drug PotentialWhy ribosomes and translation factors are viable drug targets.(00:28:56) Next Steps in Aging ResearchUsing human skin fibroblasts to study human aging mechanisms.(00:31:46) Future In a MinuteRapid-fire Q&A: scientific progress, young researchers, and archeology.(00:33:54) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

What if protein degradation could address neurodegenerative diseases, not just cancer? In this episode, Dr. Angela Cacace, CSO at Arvinas, speaks with Dr. Talar Hopyan, Global Head of CST at Syneos Health, about how the company is advancing a degrader targeting LRRK2 in Parkinson's disease and why early-stage signals in healthy volunteers are raising new possibilities for CNS care. They discuss how Arvinas is engineering blood-brain barrier-penetrant molecules, the translational challenges in neurodegeneration and what's required to move from platform to patient. What you'll learn: How Arvinas is expanding targeted protein degradation into neurology Why LRRK2 degradation is a promising approach for Parkinson's disease What it takes to translate platform innovation into measurable clinical outcomes The views expressed in this podcast belong solely to the speakers and do not represent those of their organization. If you want access to more future-focused, actionable insights to help biopharmaceutical companies better execute and succeed in a constantly evolving environment, visit the Syneos Health Insights Hub. The perspectives you'll find there are driven by dynamic research and crafted by subject matter experts focused on real answers to help guide decision-making and investment. You can find it all at https://www.syneoshealth.com/insights-hub. Like what you're hearing? Be sure to rate and review us! We want to hear from you! If there's a topic you'd like us to cover on a future episode, contact us at podcast@syneoshealth.com.

Overview This special episode of the Tick Boot Camp Podcast was recorded live at the 2nd Annual Alzheimer's Pathobiome Initiative (AlzPI) and PCOM Symposium in collaboration with Pathobiome Perspectives. Hosted by Ali Moresco in partnership with Nikki Schultek, Executive Director of AlzPI, this series expands the Tick Boot Camp mission of exploring infection-associated chronic illness (IACI)—including Lyme and other tick-borne infections—to the global Alzheimer's and neuroimmunology research community. Tick Boot Camp co-founders Matt Sabatello and Rich Johannesen partnered with Ali and Nikki to showcase scientists exploring the microbial and immune mechanisms behind neurodegeneration. This episode features Dr. Janice Bush, a PhD candidate at North Carolina State University's College of Veterinary Medicine, whose research under world-renowned Bartonella expert Dr. Edward Breitschwerdt investigates how Bartonella bacteria alter gene expression in the brain's immune cells. Guest Janice Bush, DVM, PhD Candidate College of Veterinary Medicine, North Carolina State University (NCSU) Dr. Janice Bush began her career in veterinary medicine, where she observed a striking overlap between illnesses in pets and their human owners—particularly those linked to vector-borne infections like Bartonella. Now completing her PhD under Dr. Edward Breitschwerdt, she focuses on Bartonella henselae, the bacterium behind Cat Scratch Disease, and its ability to infect human microglial cells—the brain's resident immune defenders. Her presentation, “Bartonella-Infected Human Microglial Cells: Transcriptional Changes Associated with Chronic Neurologic Disorders,” revealed how this stealth pathogen triggers widespread gene dysregulation linked to Alzheimer's disease, psychiatric symptoms, and neurodegenerative processes. Key Discussion Points Dr. Bush explains how Bartonella infection reprograms human microglia, the brain's innate immune cells, leading to hundreds of genes being upregulated or suppressed—affecting energy metabolism, mitochondrial function, cell signaling, and immune communication. These cellular changes mirror those observed in chronic neurological and psychiatric disorders, providing a potential mechanistic link between infection and long-term neurodegeneration. She describes Bartonella's sophisticated immune evasion strategy, including its ability to hijack cellular machinery and increase production of interleukin-10 (IL-10)—an anti-inflammatory cytokine that suppresses immune response, allowing the bacteria to persist undetected. This mechanism may explain why patients experience cyclic flares and remissions, and why Bartonella can linger silently for years. Dr. Bush's findings suggest that even short-term infections can produce measurable transcriptional changes in brain immune cells within 48 hours. If such infections persist for months or years, they may set the stage for neurodegenerative disease, particularly when combined with other pathogens or environmental factors. “If one intracellular pathogen can cause this many changes in two days, imagine what happens over months or years. Bartonella may be the spark that primes the brain for neurodegeneration.” — Dr. Janice Bush Why It Matters Dr. Bush's research offers a groundbreaking look at how a common, underrecognized infection may drive neuroinflammation and neurodegeneration. Her work bridges veterinary medicine, infectious disease, and neurology—revealing how pathogens once dismissed as minor or self-limiting may alter the brain's immune landscape. By demonstrating that Bartonella can infect and manipulate microglial cells, she provides critical biological evidence linking vector-borne disease and cognitive decline, paving the way for future diagnostic and therapeutic innovation. About the Event This interview was recorded at the 2nd Annual Alzheimer's Pathobiome Initiative (AlzPI) and Philadelphia College of Osteopathic Medicine (PCOM) Symposium, held October 3, 2025, at Ohio University in Dublin, Ohio. The event gathered more than 20 leading researchers exploring how microbes, the microbiome, and immune dysregulation contribute to Alzheimer's, dementia, and infection-associated chronic illness (IACI). The Tick Boot Camp Podcast, in partnership with Ali Moresco and Nikki Schultek, documented these conversations to connect the chronic Lyme, infectious disease, and Alzheimer's research communities. This episode is part of Tick Boot Camp's AlzPI collaboration series. Learn More Learn more about the Alzheimer's Pathobiome Initiative (AlzPI) Listen to Tick Boot Camp Podcast episodes, including Episode 406: Pathobiome – An Interview with Nikki Schultek and Episode 101: The Young Gun – An Interview with Alex (Ali) Moresco discussed in this interview.

Chronic traumatic encephalopathy, or CTE, is a neurodegenerative disease linked to repeated head injuries. It has been found in professional athletes, soldiers, and others who have experienced years of those traumas. New research from Harvard Griffin GSAS alumni Chanthia Ma and Guanlan Dong may help us better understand this condition. Their study looks at the smallest units of brain biology—individual neurons—and finds surprising clues written in the DNA itself. Using single-cell genome sequencing, they discovered that neurons in people with CTE carry distinctive patterns of genetic damage—patterns that may overlap with those seen in Alzheimer's disease. In this episode of Colloquy, Ma discusses how her work not only sheds light on how brain trauma leads to long-term decline but also hints at possible shared mechanisms across different neurodegenerative conditions.

What if an Alzheimer's therapy did not just slow decline, but restored memory and physical health back to baseline?In this episode of Spark Time, we sit down with Dan Salain, President and CEO of Recall Therapeutics, and Dr. Atul Chopra, Co-founder and CSO, to unpack one of the boldest ideas in neuroscience today: RTX-100, a gene therapy designed to restore cognition and systemic health in Alzheimer's disease. Dan and Atul walk us through the science behind targeting memory circuits rather than just clearing amyloid, how a liver-expressed protein naturally crosses the blood–brain barrier, and why their preclinical data show full recovery of associative, recognition, and spatial memory in advanced mouse models.We also explore the overlooked systemic side of Alzheimer's cachexia, sarcopenia, frailty, UTIs, pneumonia and how RTX-100 appears to normalize body weight, muscle strength, endurance, and fluid balance alongside cognitive recovery. From serendipity in the lab to regulatory strategy and potential paths to market, this conversation opens up a very different vision for what treating Alzheimer's and even aging itself could look like.

Nutritionist Leyla Muedin focuses on a new perspective in Alzheimer's research, particularly the role of microglial cells. She reveals insights from integrative neurologist Dr. David Perlmutter's presentation at the Integrative Healthcare Symposium, emphasizing the significance of microglial cells in Alzheimer's disease. The discussion highlights the traditional focus on beta amyloid plaques and introduces the importance of shifting from the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype of microglial cells. Dr. Perlmutter advocates for addressing systemic metabolic and inflammatory issues, pointing out factors like poor diet, lack of sleep, and high blood sugar, which are crucial in preventing Alzheimer's. The episode delves into lifestyle interventions such as ketogenic diets, fasting, and nutritional impacts to manage and potentially reverse the detrimental shift in microglial behavior.

In today's episode, Dr. Kirk Gair shares how a routine imaging procedure turned his family's life upside down, sending his wife into a severe health crisis that conventional medicine couldn't solve. Faced with life-threatening symptoms and a string of specialists who could offer no answers, he turned to his old friend and functional medicine expert, Dr. Datis Kharrazian. Together, they uncovered an autoimmune thyroid reaction triggered by iodine, and charted a new path—combining advanced functional medicine protocols with cutting-edge low-level laser therapy.You'll learn how this approach not only reversed his wife's decline, but also explores the science and global potential of lasers in supporting chronic conditions, brain health, and autoimmune disease. Enroll in the complete master class: Enhanced Healing & Performance with High Energy Non-Thermal Laser Therapy with Dr. Kirk Gair at: https://pages.kharrazianinstitute.com/erchonia For patient-oriented functional medicine courses, visit https://drknews.com/online-courses/For practitioner functional medicine certification courses, visit https://kharrazianinstitute.com/For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/00:00 "ER Visit Misdiagnosed as Panic"05:29 Healing Brain with Laser Therapy06:27 "Laser Therapy for Inflammation Control"12:31 Laser Therapy for Neurological Recovery13:12 "Laser and Functional Medicine Success"17:39 Childhood Crash Causes Lifelong Injuries20:33 "Brian's Transformation: A Waking Brain"23:49 Autoimmunity Rise and Environmental Impact28:08 "Solving the Puzzle Podcast"Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Just 4 simple lifestyle measures deliver 9 additional years of disease-free healthspan; Study underscores protein's role in staving off cancer, heart disease, and death; CoQ10 scores vs. neurodegeneration; Urolithin A (Mitopure®️) found to support athletic performance, immune function; Why you should ignore some influencers' advice to avoid fish oil. 

Emily is an Assistant Professor at MDI Biological Laboratory where she studies neurodegenerative disease-associated genes using super-resolution imaging of living, adult worms. Emily earned her Ph.D. at the University of Maine while embedded in the Jackson Laboratory and during her post-doc at MDI Bio Lab, she was recognized by the National Institutes of Health as an “Outstanding Scholar in Neuroscience”.This conversation was recorded in September 2025. ~~~~~The Maine Science Podcast is a production of the Maine Discovery Museum. It is recorded at Discovery Studios, at the Maine Discovery Museum, in Bangor, ME. The Maine Science Podcast is hosted and executive produced by Kate Dickerson; edited and produced by Scott Loiselle. The Discover Maine theme was composed and performed by Nick Parker. To support our work: https://www.mainediscoverymuseum.org/donate. Find us online:Maine Discovery MuseumMaine Discovery Museum on social media: Facebook Instagram LinkedIn Bluesky Maine Science Festival on social media: Facebook Instagram LinkedInMaine Science Podcast on social media: Facebook Instagram © 2025 Maine Discovery Museum

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/In this video, I break down ATX-304 (also known as OS-01 or OS-03) — a powerful small molecule AMPK activator being studied for fat loss, metabolic health, and longevity. If you've heard ATX-304 described as “exercise in a capsule,” you'll see why after going through the research, mechanisms, human trials, and potential applications.I also share how ATX-304 works differently than GLP-1s, why it preserves muscle while supporting fat loss, and what the future may hold for this compound in anti-aging medicine.

There is an important role for cost-effective clinical biomarkers in the diagnosis of Parkinson's disease. Dr. Eduardo de Pablo-Fernández and Dr. Cecilia Tremblay discuss how accurate hyposmia and REM sleep behavior disorder can predict Lewy pathology in a non-selected population using data from the Arizona clinicopathological study on Aging and Neurodegeneration. Read the article.

In this episode, Dr. John E. Lewis returns to the podcast to explore the autoimmune and neurodegenerative aspects of multiple sclerosis — and how nutrition, supplements, and exercise can help change its trajectory… Hit play to learn: The leading cause of death for people with multiple sclerosis. The key protein for central nervous system repair. The genetic characteristics of immune system functioning. The role that diet plays in enhancing gastrointestinal health.  Dr. Lewis is dedicated to showing how nutrition and supplementation can optimize health. He is the founder and president of Dr. Lewis Nutrition®, a former Associate Professor in the Department of Psychiatry and Behavioral Sciences at the University of Miami Miller School of Medicine, and a Diplomate, Faculty Member, and Advisor of the Medical Wellness Association. Over his career, Dr. Lewis has led more than 30 human health studies, helping raise over $23 million in research funding. He has published more than 180 peer-reviewed papers, lectured around the world, appeared on television, and mentored students from undergraduate to post-doctoral levels.  Want to learn more about how Dr. Lewis's work continues to bridge clinical research with practical health strategies for everyday life? Join the conversation now!

In this episode of the Ageless Future podcast, host Cade Archibald dives deep into the gut-brain connection and how detoxing the digestive system can revitalize the immune system, boost energy, and improve mental clarity. Cade explains how gut imbalances, toxin overload, and vagus nerve dysfunction can lead to chronic fatigue, inflammation, neurodegeneration, and other health challenges. He shares practical strategies such as targeted peptides, mitochondrial support, and anti-inflammatory nutrition, along with a four-week gut-brain detox action plan to heal the gut lining, restore microbial balance, and optimize detox pathways. Listeners also learn about advanced treatments like umbilical cord plasma therapy and fecal microbiota transplants, as well as simple daily habits to strengthen the gut-brain axis for long-term vitality. www.agelessfuture.com

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

Report shows rapid declines in health of children and adolescents since 2007; N-acetylcysteine (NAC) for Parkinson's; Statins increase likelihood of hearing loss, tinnitus; Lithium orotate for Alzheimer's; Is tinnitus reversible? Novel implantable electrical vagus nerve stimulator approved for treatment of rheumatoid arthritis.

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with Dr. Vass Eliopoulos, co-founder of Longevity Health and a pioneer at the intersection of regenerative medicine, longevity science, and psychedelics. Find full show notes and links here: https://thethirdwave.co/podcast/episode-314/?ref=278 Dr. Vass shares his journey from emergency medicine to a proactive, prevention-based approach to health optimization for high performers. Dr. Vass shares why today's healthcare system fails to address the root causes of disease, the synergistic potential of psychedelics, stem cells, peptides, and hyperbaric oxygen therapy, and how chronic stress and inflammation underlie many modern conditions. He also outlines why psychedelics may be essential in reversing chronic inflammation and treating neurodegenerative diseases—and how prevention, not pathology, should guide the future of medicine. Dr. Vassily Eliopoulos (Dr. Vass) is the Co-Founder and Chief Medical Officer of Longevity Health, a cutting-edge regenerative medicine clinic in Boulder, Colorado. A former ER physician and Peace Corps volunteer, Dr. Vass now helps high performers optimize their health through advanced diagnostics, regenerative therapies, and personalized plans. A black belt in Brazilian Jiu-Jitsu, avid climber, and kayaker, he brings deep experience in resilience and recovery to his clinical work. Highlights: Why Vass left emergency medicine for longevity health COVID as a catalyst for self-directed wellness The failure of “sick care” to promote true health Psychedelics as first-line treatments for mental health Chronic stress, inflammation, and disease progression Synergies between psychedelics, stem cells, and peptides Prevention vs. pathology in modern medicine Neurodegeneration as chronic brain injury Future directions for regenerative and psychedelic therapies Curious about becoming a certified psychedelic coach? Join Paul F. Austin Thursday, July 31 2025, 10:00 AM PT for a free info session exploring the Psychedelic Coaching Institute's Practitioner Certification Program—an immersive training that blends science, ceremony, and real-world coaching to help you lead others through lasting transformation. Learn More. Episode Links: Longevity Health Clinic Dr. Vassily's Instagram Episode Sponsor: Golden Rule Mushrooms - Get a lifetime discount of 10% with code THIRDWAVE at checkout

New Study Alert!

ReferencesFront. Immunol., 22 February 2024Sec.Multiple Sclerosis and Neuroimmunology Volume 15 Arthritis Care Res (Hoboken). 2024 Aug 7;76(11):1451–1460Nat Immunol. 2024 Apr 8;25(5):778–789Lake, G 1972 "From the Beginning" ELP Trilogy lp.https://music.youtube.com/watch?v=hsJ9YXHqnr8&si=NoG1BHKOtrFNYItmJoel, B. 1972. "Scenes from An Italian Restaurant. Yhe Stranger lphttps://music.youtube.com/watch?v=rdAvFvDVXSk&si=_BhtdE6WKN2J80FV

ReferencesFront. Immunol., 22 February 2024. Sec. Multiple Sclerosis and Neuroimmunology Volume 15 Nat Cell Biol. 2019 Mar; 21(3): 397–407.CELL 2006. Volume 126, Issue 3, 11 August Pages 503-514Valenti, D. 1971. "Dont Cry My Lady Love"https://music.youtube.com/watch?v=Aqt0yhGfC1s&si=fXpd1HifSgtEHtpbLennon/McCartney. 1966. "For No One"Revolver. lp.https://music.youtube.com/watch?v=ELlLIwhvknk&si=ZgDZXKn_UPC3RHBmMozart, WA. 1773. Symphony 25 in G Minorhttps://music.youtube.com/watch?v=707oHEGF6l8&si=rwJRSJ2CeYfYVIas

For more information and support, visit us at our NEW WEBSITE! https://www.thecirsgroup.com This week, we are continuing our recap of the CIRSx 2025 conference! Today, we are focusing on the treatment talks: Understanding the Pitfalls of Tick Borne Testing with Christian Navarro Torres, PhD, CIRS Lab Finding the Tick-Borne Needle in the Haystack: Tick Borne Infections in CIRS Patients with Peg DiTulio, DNP, APRN Diagnosing Lyme and Co-infections: An Investigation of the Availability, Diversity and Validity of the Current Testing with Dr. Laura Varga, DAOM Air Oasis EdTalk with Brad Baxter, COO A Unifying Theory of Neurodegeneration with Dr. Dale Bredesen The Actinobacteria Reduction Study: Making Life Easier for the CIRS Community with Eric Dorninger, ND, LAc Brain Injury in CIRS: From Specific Causation to a Unique Transcriptomic Fingerprint in Parkinson's with Dr. Ritchie Shoemaker The Principles of Body Typing as a Critical Tool for CIRS Success with Erin Livers , BA, ICNT Evidence-based Diagnoses and Strategies for the CIRS Microbiome with Dr. Lacey Venazi For more information and support, visit us at our NEW WEBSITE! https://www.thecirsgroup.com TIMESTAMPS 00:00 Introduction and disclaimer 00:45 Tick-Borne testing insights by Dr. Christian Navarro-Torres, Dr. Peg DiTulio, Dr. Laura Varga 09:02 AirOasis ED Talk by Brad Baxter 11:19 Dr. Dale Bredesen's Keynote on Alzheimer's and Neurodegeneration 15:46 Actinobacteria Reduction Study by Dr. Eric Dorninger 18:20 Dr. Shoemaker's Talk on Parkinson's Research 20:45 Principles of Body Typing for Nutrition by Nutritionist Erin Livers 23:23 CIRS and the Gut Microbiome by Dr. Lacey Venazi 27:41 Conclusion and Additional Resources Helpful links/info: CIRSx website: https://www.cirsx.com/ Dr. Christian Navarro-Torres' website: https://www.cirslab.com/ Dr. Peg DiTulio's website: https://regenixhealing.com/ Dr. Laura Varga: https://www.instagram.com/thejupiterapproach/ or email her at TheJupiterApproach@gmail.com Air Oasis website: https://www.airoasis.com/ Dr. Dale Bredesen's website: https://www.apollohealthco.com/dr-bredesen/ The Flow Free game Jacie plays: https://www.bgames.com/game/flow-free-online/ Our last CIRSx recap episode: https://youtu.be/0aLD_1ixWXU?si=5-DxFVxgy7dleux3 Dr. Eric Dorninger's website: https://drdorninger.com/ Dr. Ritchie Shoemaker's website: https://www.survivingmold.com/ Erin Livers' website: https://foodasnourishment.com/ Dr. Abravanel's Body Type Diet and Lifetime Nutrition Plan: https://a.co/d/g6Z1bP7 Dr. Lacey Venazi's website: https://www.drlacey.org/ Order Jacie's book! The 30 Day Carnivore Bootcamp: https://a.co/d/7MgHrRs The CIRS Group: Support Community: https://thecirsgroup.com Instagram: https://www.instagram.com/thecirsgroup/ Find Jacie for carnivore, lifestyle and limbic resources: Jacie's book on the Carnivore diet!  https://a.co/d/8ZKCqz0 Instagram: https://www.instagram.com/ladycarnivory YouTube: https://www.youtube.com/@LadyCarnivory Blog: https://www.ladycarnivory.com/ Find Barbara for business/finance tips and coaching: Website: https://www.actlikebarbara.com/ Instagram: https://www.instagram.com/actlikebarbara/ YouTube: https://www.youtube.com/@actlikebarbara Jacie is a Shoemaker certified Proficiency Partner, NASM certified nutrition coach, author, and carnivore recipe developer determined to share the life changing information of carnivore and CIRS to anyone who will listen. Barbara is a business and fitness coach, CIRS and ADHD advocate, writer, speaker, and a big fan of health and freedom. Together, they co-founded The CIRS Group, an online support community to help people that are struggling with their CIRS diagnosis and treatment.

PhD in synthetic chemistry, the Product Formulator for Supplement Needs, and fitness industry renowned Pharmacologist for his no-nonsense approach in bodybuildingThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com2:19 Bodybuilding Pharmacology and Dosing4:53 Brain Health and Long-Term Risks7:29 Muscle Building and Genetic Factors10:03 Cholesterol and LDL Impacts12:14 Podcast Setup and Equipment Upgrades14:34 Hair Transplant Journey24:23 Hair Loss Causes and Treatments34:59 Post-Transplant Recovery and Rebound39:31 Epigenetics and Muscle Memory43:04 Ethical Questions on Genetic Enhancement45:40 Enhanced Games Debate50:09 Dosing Challenges in Enhanced Sports52:32 Data Collection and Human Experimentation55:16 Genetic Variance and Elite Athletes59:04 Neurodegeneration and PEDs1:07:08 Oxidative Stress in Bodybuilding1:09:37 Sleep and Brain Detox1:18:01 Nutrition for Oxidative Stress1:19:02 Melatonin as an Antioxidant1:21:13 Melatonin Dosing and Effects1:24:51 Melatonin and Sleep Support Supplements1:28:22 Magnesium and Sleep Health1:31:23 Sleep Apnea and Neural Health1:36:30 Frequent Urination at Night1:46:33 Overheating During Sleep1:59:14 Wrapping Up Oxidative Stress2:00:33 Neuron Loss and Neurotransmitters2:02:04 Boosting Brain Health with BDNF2:04:08 Peptides for Neural Growth2:09:14 Oxidative Stress and Supplements2:12:34 Neuroprotection Strategies2:19:56 EMF and Environmental Stressors2:22:12 Mitochondrial Dysfunction and Aging2:24:55 Balancing Oxidative Stress2:28:32 Steroids and Muscle Growth Rates2:38:54 HDL and LDL Control Ancillaries2:41:34 Statins and LDL Oxidation2:47:36 Antioxidants and Plaque Formation2:54:10 Balancing Cholesterol Levels2:58:35 CT Scans for Heart Health3:03:54 Heart Health Supplements3:06:48 Mitochondrial Stack Under 303:16:27 Balanced Diet in Prep3:20:24 Omega-3 and Fish Oil Quality3:23:36 Podcast Wrap-Up

This episode of Integrative You Radio dives deep into the misunderstood world of neurodegenerative diseases—especially ALS (Amyotrophic Lateral Sclerosis). Dr. Nicole and Dr. Nick unravel the hidden connections between environmental toxins, like cyanide and algae exposure, and the emotional roots of disease, such as self-betrayal and the “Nice Guy Syndrome.” They challenge the conventional view of ALS as just a physical diagnosis, shining a light on how a lack of self-love and unexpressed truth can manifest physically. The Doctors share practical wisdom on breaking free from people-pleasing, the importance of knowing your values, and how real healing starts with radical self-awareness and communication.   #ALS #NeurodegenerativeDisease #SelfLove #IntegrativeMedicine #RootCauseHealing #PeoplePleasing #ValuesDriven #FunctionalMedicine #EmotionalHealth #SpeakYourTruth #HolisticHealth #MindBodyConnection #WellnessJourney #DrNicoleRivera #DrNickCarruthers #IntegrativeYou   3 Key Takeaways: ALS and other neurodegenerative diseases may be linked to cyanide exposure—not just from the environment but from internal sources like cyanobacteria (blue-green algae), highlighting the need for deeper diagnostic approaches. Long-term people-pleasing, self-betrayal, and putting yourself last (especially for parents and caregivers) can create profound stress and disconnection from self, which may contribute to disease. True healing begins with radical self-love, clear communication, and living in alignment with your core values—knowing who you are is the foundation for transformation.    Quotes:  “Every single aspect of disease is literally how far away from love are you? And that will equal the degree of the disease.” – Dr. Nick “If you're not going to speak up and exercise your truth, or stand for yourself, you're mentally not speaking up—and that can manifest as a physical disease.” – Dr. Nicole   Find Integrative You Radio On: Website Youtube  Apple Spotify   2 Doctors Committed to Innovating the Healthcare Experience. Integrative You Radio is hosted by husband-and-wife duo, Dr. Nicole Rivera and Dr. Nick Carruthers. With their voracious curiosity for Integrative Medicine, the Human Mind, Aligned Parenting, and Entrepreneurship, they bring a fresh perspective to the table. They aim to debunk the BS that is holding you back in your health, your relationships, and your life. Each episode is designed to challenge your thinking, push boundaries, and inspire you to see your life through a new lens. Dr. Nicole and Dr. Nick share transformative insights that have revolutionized their lives and the lives of their clients at Integrative You. This is raw. This is real. This is Integrative You Radio— where we blow shit up for the sake of human innovation.   Links: Website: Integrative You Instagram: Dr. Nicole Rivera & Integrative You Ready to Move from Awareness to Action? If today's episode on ALS and neurodegenerative disease resonated with you—if you saw yourself in the conversation about people-pleasing, self-betrayal, or putting yourself last—don't let this be just another inspiring listen. Take the next step toward real change: Start With Your Core: We talked about how true healing starts with knowing your values and who you are at your core. Our Values Determination Course is the perfect place to begin if you're ready to break old patterns, set new boundaries, and create a life aligned with your truth. Discover your values and start your transformation here: https://www.integrativeyou.health/offers/nkCsvtRJ/checkout  Strengthen Your Relationships: If you realized your communication rhythms at home need a reset, or you're ready to move beyond surface-level connection with your partner, our Aligned Couples Course gives you the exact strategies we use for real, lasting partnership and honest feedback. Elevate your relationship—get started with the Aligned Couples Course: https://www.integrativeyou.health/offers/BZzwFLW3/checkout   Get Personalized, Root-Cause Care: For those who want to dig deeper—whether you're facing chronic illness, mystery symptoms, or just want a high-touch, holistic approach—our Concierge Integrative Medicine program is here for you. We blend advanced diagnostics, values work, and ongoing support so you're not just treating symptoms, but rewriting your story from the inside out. Apply for your private integrative experience now: https://www.integrativeyou.health/onboarding  You don't have to settle for “just getting by.” Whether you're ready to do the inner work, transform your relationships, or get truly personalized care, we're here to help you create your Limitless 2.0 life.   Got questions? You can call or text us at 732-810-1084.

What if you could reverse the age of your heart...without leaving home? In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You'll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart's energy systems. Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You'll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan. What You'll Learn in This Episode: • The link between mitochondrial decline and heart failure • Why women's cardiac risk skyrockets after menopause • How Urolithin A stimulates mitophagy and energy renewal • New human clinical data on reversing cardiac aging markers • Biohacking strategies to fortify your cardiovascular health • How to optimize endurance, recovery, and heart resilience THANK YOU TO OUR SPONSORS! -STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Timeline Website – https://www.timeline.com/partners/dave-asprey • Timeline Instagram - https://www.instagram.com/timeline_longevity/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 — Trailer • 02:11 — Supplements that help • 03:05 — Long-term benefits • 04:38 — Stacking with lifestyle • 22:19 — Heart health connection • 29:39 — Mitochondria & brain function • 33:04 — Glymphatic system & Alzheimer's • 33:53 — Bed height & brain health • 34:18 — Why mitochondria matter • 35:43 — Inflammation & dysfunction • 38:12 — Transplants & consciousness • 39:19 — Meditation's effects • 40:33 — The ultimate biohacking stack • 43:06 — Creatine for sleep & focus • 50:00 — Fertility insights • 57:23 — Skin health • 01:00:28 — Final thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

America Out Loud PULSE with Dr. Randall Bock – I investigate Alzheimer's, Parkinson's, and ALS neurodegeneration, revealing how protein aggregates, inflammation, and DNA damage drive brain decay. Using genetic markers, blood tests, animal models, lab‑grown mini‑brains, and NIH data, I aim to detect disease extremely early and develop targeted treatments that consider genetics and sex for more effective interventions.

In this episode, we're going deep on Carbon 60—also known as C60 or buckyballs. If you've ever wondered how a molecule that started life as an industrial lubricant ended up a star player in the world of anti-aging, you're in for a treat. Ian and I talk about the original studies that blew everyone's minds (including a rat study where the animals lived nearly twice as long as expected!), and we discuss Ian's own hands-on research, from mouse models to dogs, horses, and even human applications.   What we discuss: C60 explained: origins, “buckyballs,” and research ... 00:08 C60 rat and mouse longevity studies ... 00:09 Lipid binding & targeted delivery ... 00:16 C60: antioxidant, adaptogen, mitochondrial effects ... 00:18 Athlete case study & performance benefits ... 00:25 Applications for fatigue, brain fog, metabolic issues ... 00:32 Autoimmune/inflammatory benefits & mitochondrial origins ... 00:34 Hair, scalp, and ovarian health ... 00:38 Neurodegeneration, glymphatics & brain serums ... 00:45 Optimizing cognition & cycling C60 ... 00:51 Safety notes: who should avoid and why ... 00:53 Product lineup & new developments ... 01:01 What to look for in C60 products ... 01:09   Our Amazing Sponsors: LVLUP - Neuro Re-Generate the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT10 for 10% off your order.   Peptide Pro App - When you're working with multiple peptides, timing and precision matter. From smart scheduling to real-time dose checklists, it keeps things organized and on track. Receive 50% off for the first month. Visit www.peptidepro.app to download the app and use code NATHALIE50 to get started today.   Wizard Sciences (Neural Rx) - designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. Plus, it supports mitochondrial efficiency, meaning more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com.    Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group