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6 episodes with Neurodegeneration
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About the Guest(s): Dr. Laura Standridge: Dr. Laura Standridge is a prominent functional chiropractor known for her expertise in pediatric neurological development and genetic disorders. She is board certified in neurofeedback and specializes in approaches that focus on neurodevelopmental assessments, particularly concerning mitochondrial function and primitive reflexes. Dr. Standridge has gained attention for her work with rare neurodegenerative disorders, particularly BPAN, following her son's diagnosis with the disease. Her professional journey is marked by a dedication to understanding and improving neurological health through innovative methods in functional and integrative healthcare. Episode Summary: In this enlightening episode of Functional Health Radio, Dr. Kristin Hieshetter delves deep into the pressing health crises in America, revealing that the country's life expectancy has not only plateaued but declined for both men and women. Despite the high per capita healthcare expenditure, conditions like heart disease and cancer remain prevalent, and children are increasingly diagnosed with chronic diseases. The discussion transitions into a heartfelt narrative with Dr. Laura Standridge, a functional chiropractor passionately occupied with her son Laird's rare neurodegenerative disease known as BPAN (Beta-propeller Protein-Associated Neurodegeneration). BPAN, characterized by iron accumulation in the brain, is a daunting diagnosis for any family, but Dr. Standridge shares her proactive approach to defy the medical script of decline. Employing advanced genetic testing and leveraging her deep understanding of functional health principles, Dr. Standridge explores comprehensive interventions that have led to remarkable outcomes for Laird. From dietary adjustments to specialized neurodevelopmental therapies and state-of-the-art medical interventions, Dr. Standridge's narrative underscores a hopeful perspective—not only sharing insights about BPAN but also reflecting innovative applications of functional health practices. This episode highlights how a blend of cutting-edge science and compassionate care can write new chapters in health and wellness narratives. Key Takeaways: BPAN Disease Insight: BPAN is a rare neurodegenerative disorder that causes abnormal iron accumulation in the brain, significantly impairing mitochondrial function and autophagy. Unique Case of Laird: Laird defies the typical BPAN trajectory through a tailored combination of nutritional strategies, functional therapies, and mitochondrial enhancement techniques. Importance of Nutrition: Laird's diet, free of gluten and inflammatory foods, supports brain health by preventing autoimmune responses that can exacerbate neurological damage. Integrative Approaches: Utilization of genetic testing and innovative therapies, like low-level laser therapy, provides neuroprotective benefits and enhances Laird's quality of life. Collaborative Healthcare: Dr. Standridge exemplifies the power of interdisciplinary collaboration, uniting various specialists to support a functional health-driven roadmap for Laird. Notable Quotes: "We are walking around in the most amazing, intelligent, responsive, adapting and aware system in the world, the human. Let's bring it to its fullest potential." - Dr. Kristin Hieshetter "It doesn't matter what the label is…I'm much more interested in how you are functioning and not what somebody from the outside might call you." - Dr. Laura Standridge "We waited and we waited and we waited some more and finally received this diagnosis." - Dr. Laura Standridge "The brain is built on the postural system…and so there is this amazing order of neurological development whether you have a genetic difference or not." - Dr. Laura Standridge "Together, we'll be the change that we wish to see in the world." - Dr. Kristin Hieshetter Resources: Learn more about BPAN and related genetic testing at the CDC Vital Statistics Report: www.cdc.gov For insights into functional chiropractic care and Dr. Laura Standridge's approaches, visit Functional Health Mastery Stay informed with the World Economic Forum's health expenditure data: www.weforum.org Functional Health Mastery Group Listen to the full episode to dive deeper into the revolutionary approaches that Dr. Laura Standridge and Dr. Kristin Hieshetter share in tackling BPAN, and stay tuned for more inspiring stories and informative discussions on Functional Health Radio.
About the Guest(s): Dr. Kristin Hieshetter: Dr. Kristin Hieshetter is a distinguished functional health professional renowned for her integrative approach to wellness. With a strong background in neurodegenerative disease management and gut health, Dr. Hieshetter has been impacting lives through her podcast, "Functional Health Radio." Her dedication to evidence-based practice has propelled her podcast to the top 10% of global rankings in just six months. Dr. Hieshetter's clinical practice is underpinned by rigorous research, patient-centered care, and a deep commitment to improving health outcomes through innovative approaches like low-level laser therapy. Episode Summary: In this compelling episode of Functional Health Radio, Dr. Kristin Hieshetter delves into the intricacies of gut health and its profound impact on overall wellness. She opens with a nod to her previous episode about low-level laser therapy in neurodegenerative diseases and its life-changing potential for children. Transitioning into the current discussion, Dr. Hieshetter elaborates on how gut health significantly influences various symptoms like GI upset, brain fog, and mental health deterioration, emphasizing a holistic clinical approach. Amid her exploration of gut microbiome, Dr. Hieshetter sheds light on the critical role of nutritional choices and exposure to toxins such as MSG, aspartame, and glyphosate. Highlighting the connection between gut imbalances and systemic diseases, she shares a powerful story of a patient who traveled from Florida seeking relief from chronic gastrointestinal issues. Through advanced gut testing, Dr. Hieshetter outlines her integrative treatment strategies, underscoring the significance of vibrant gut health and its direct correlation with mental well-being, autoimmune disorders, and even neurological diseases like Parkinson's. Key Takeaways: Gut health is intricately linked to brain health, influencing symptoms like anxiety, depression, and cognitive decline. Functional testing, such as Vibrant America's Gut Zoomer, plays a vital role in diagnosing and treating gut imbalances. Avoiding harmful substances like excitotoxins and pesticides is crucial for maintaining gut and overall health. Comprehensive treatment plans, including probiotics, dietary changes, and low-level laser therapy, can significantly improve quality of life. Emotional and mental health often improve alongside physical well-being in cases of severe gut imbalances. Notable Quotes: "When there are things that I know the world needs, I know my patients need, they keep walking through my door without me asking." "Your gut microbiome is a major protector of that." "Pesticides like paraquat, they inhibit autophagy… It cleans out cancer cells that shouldn't be there." "Stop eating pesticides. Avoid them at all costs." "It's a really different topic to check out, but for the repeat listeners, you know, it's been a great journey for us all here." Resources: Vibrant America - Website Journal of Environmental Toxicology 2022 Journal of Parkinson's Disease 2023 Environmental Working Group (EWG) - Website Pelican S.L. Pentair Water Filtration System Functional Health Mastery Group Trends in Neuroscience 2013 For those seeking to enhance their understanding of functional health and explore transformative approaches to wellness, this episode is a must-listen. Tune in next week for more illuminating content from Functional Health Radio, where Dr. Kristin Hieshetter continues to share insights that can change the face of healthcare.
Revolutionizing Regenerative Medicine: The Power of Mass-Produced Mitochondria: Nutritionist Leyla Muedin explores groundbreaking research on stem cell-based methods to mass-produce human mitochondria, which could revolutionize regenerative and anti-aging medicine. She delves into the science and potential health benefits, discussing how increased mitochondrial production can improve conditions like osteoarthritis, heart disease, and neurodegenerative disorders. Leyla also provides practical advice on ways to enhance mitochondrial health through dietary and supplement strategies, offering listeners actionable steps to boost their health span and lifespan.
What if you could reverse the age of your heart...without leaving home? In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You'll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart's energy systems. Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You'll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan. What You'll Learn in This Episode: • The link between mitochondrial decline and heart failure • Why women's cardiac risk skyrockets after menopause • How Urolithin A stimulates mitophagy and energy renewal • New human clinical data on reversing cardiac aging markers • Biohacking strategies to fortify your cardiovascular health • How to optimize endurance, recovery, and heart resilience THANK YOU TO OUR SPONSORS! -STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Timeline Website – https://www.timeline.com/partners/dave-asprey • Timeline Instagram - https://www.instagram.com/timeline_longevity/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 — Trailer • 02:11 — Supplements that help • 03:05 — Long-term benefits • 04:38 — Stacking with lifestyle • 22:19 — Heart health connection • 29:39 — Mitochondria & brain function • 33:04 — Glymphatic system & Alzheimer's • 33:53 — Bed height & brain health • 34:18 — Why mitochondria matter • 35:43 — Inflammation & dysfunction • 38:12 — Transplants & consciousness • 39:19 — Meditation's effects • 40:33 — The ultimate biohacking stack • 43:06 — Creatine for sleep & focus • 50:00 — Fertility insights • 57:23 — Skin health • 01:00:28 — Final thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
America Out Loud PULSE with Dr. Randall Bock – I investigate Alzheimer's, Parkinson's, and ALS neurodegeneration, revealing how protein aggregates, inflammation, and DNA damage drive brain decay. Using genetic markers, blood tests, animal models, lab‑grown mini‑brains, and NIH data, I aim to detect disease extremely early and develop targeted treatments that consider genetics and sex for more effective interventions.
America Out Loud PULSE with Dr. Randall Bock – I investigate Alzheimer's, Parkinson's, and ALS neurodegeneration, revealing how protein aggregates, inflammation, and DNA damage drive brain decay. Using genetic markers, blood tests, animal models, lab‑grown mini‑brains, and NIH data, I aim to detect disease extremely early and develop targeted treatments that consider genetics and sex for more effective interventions.
In this episode, we're going deep on Carbon 60—also known as C60 or buckyballs. If you've ever wondered how a molecule that started life as an industrial lubricant ended up a star player in the world of anti-aging, you're in for a treat. Ian and I talk about the original studies that blew everyone's minds (including a rat study where the animals lived nearly twice as long as expected!), and we discuss Ian's own hands-on research, from mouse models to dogs, horses, and even human applications. What we discuss: C60 explained: origins, “buckyballs,” and research ... 00:08 C60 rat and mouse longevity studies ... 00:09 Lipid binding & targeted delivery ... 00:16 C60: antioxidant, adaptogen, mitochondrial effects ... 00:18 Athlete case study & performance benefits ... 00:25 Applications for fatigue, brain fog, metabolic issues ... 00:32 Autoimmune/inflammatory benefits & mitochondrial origins ... 00:34 Hair, scalp, and ovarian health ... 00:38 Neurodegeneration, glymphatics & brain serums ... 00:45 Optimizing cognition & cycling C60 ... 00:51 Safety notes: who should avoid and why ... 00:53 Product lineup & new developments ... 01:01 What to look for in C60 products ... 01:09 Our Amazing Sponsors: LVLUP - Neuro Re-Generate the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT10 for 10% off your order. Peptide Pro App - When you're working with multiple peptides, timing and precision matter. From smart scheduling to real-time dose checklists, it keeps things organized and on track. Receive 50% off for the first month. Visit www.peptidepro.app to download the app and use code NATHALIE50 to get started today. Wizard Sciences (Neural Rx) - designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. Plus, it supports mitochondrial efficiency, meaning more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
In this episode, I'm joined by Dr. Dale Bredesen, a true pioneer in Alzheimer's research and functional medicine. Together, we dive into groundbreaking advancements in the world of neurodegenerative diseases, with a special focus on the exciting breakthroughs in detecting and potentially reversing Alzheimer's and other related conditions. Dr. Bredesen sheds light on the new disease mechanisms and innovative blood tests that are changing the game, showing us that cognitive decline isn't something we simply have to accept. We also explore his integrative approach to combating Alzheimer's, which includes lifestyle modifications, early detection, and a holistic strategy for better brain health. This conversation is packed with hope and real strategies for a future where Alzheimer's doesn't have to be inevitable. Key Takeaways: New Era of Research: Alzheimer's and similar neurodegenerative diseases are not death sentences, thanks to innovative research and new treatment protocols that emphasize early detection and intervention. Significance of Gut Health: Investigations reveal that gut microbiota and inflammation are crucial risk factors in cognitive decline, underscoring the importance of gut health in preventing Alzheimer's. Role of Lifestyle Changes: Diet, exercise, sleep, and stress management are integral to maintaining brain health and can significantly influence the progression of neurodegenerative diseases. Advance in Diagnostics: Cutting-edge blood tests such as P Tau217 and brain scans can detect early signs of Alzheimer's up to 20 years prior to diagnosis, offering opportunities for preemptive action. The Power of Personalized Medicine: Individualized protocols based on genetic testing, like assessing APOE status, are pivotal in developing effective prevention and treatment strategies for cognitive disorders. More About Dr. Dale Bredesen: Dr. Dale Bredesen, M.D., is a globally recognized expert in neurodegenerative diseases, particularly Alzheimer's disease. With a background that includes graduating from Caltech and earning his M.D. from Duke University Medical Center, Dr. Bredesen's career is marked by groundbreaking research and clinical expertise. He completed his residency as chief resident in neurology at UCSF and further honed his skills at Nobel laureate Stanley Prusiner's lab at UCSF as an NIH postdoctoral fellow. Dr. Bredesen's academic career includes faculty positions at prestigious institutions like UCSF, UCLA, and UC San Diego. As the founding president and CEO of the Buck Institute for Research on Aging, he spearheaded pioneering work in the study of aging and neurodegenerative diseases. Currently, he serves as the chief medical officer of MPI Cognition, where he continues his innovative research and efforts to combat Alzheimer's and related conditions. Dr. Bredesen's expertise and leadership have made him a key figure in the field, with a focus on integrative approaches to prevent and reverse cognitive decline. His contributions are reshaping our understanding of neurodegenerative diseases, offering new hope for those affected by them. Website Instagram Take a Cognitive Assessment here: https://www.apollohealthco.com/know-your-cq/ Get a brain scan: https://getabrainscan.com/ KetoFLEX 12/3: https://www.trifectanutrition.com/apollohealthpartner Connect with me! Website Instagram Facebook YouTube This episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more! This episode is also made possible by Functional Medicine University. FMU is a fully online, self-paced training program in functional medicine, founded in 2006 by Dr. Ron Grisanti. With students in all 50 U.S. states and 68 countries globally, FMU has become a cornerstone in advanced clinical education for healthcare practitioners. The curriculum is led by Dr. Grisanti, alongside contributions from over 70 distinguished medical experts on FMU's advisory board. Graduates earn the prestigious Certified Functional Medicine Practitioner (CFMP®) credential upon completion. FMU is also a nationally approved provider of continuing education for a wide range of licensed professionals, including MDs, DCs, DOs, NDs, acupuncturists, PAs, NPs, nurses, dietitians, pharmacists, and dentists. Whether you're looking to expand your clinical knowledge or bring a functional approach to your practice, FMU offers the tools, guidance, and certification to help you thrive. Visit www.functionalmedicineuniversity.com to learn more!
On this week's installment of the Real Health Podcast, Dr. Reed Jarvis talks about what neurodegeneration is defined as and what are the best ways to combat it decades in advance. All of this and more on the Real Health Podcast!
The blood-brain barrier (BBB)
There is an important role for cost-effective clinical biomarkers in the diagnosis of Parkinson's disease. Dr. Eduardo de Pablo-Fernández and Dr. Cecilia Tremblay discuss how accurate hyposmia and REM sleep behavior disorder can predict Lewy pathology in a non-selected population using data from the Arizona clinicopathological study on Aging and Neurodegeneration. Read the article.
CT scan accidentally reveals calcium deposits where they don't belong; Dispelling the myth that hunter-gatherers get more sleep than Westerners; Blue light exposure at night impairs sleep—but morning exposure improves it; When normal B12 levels aren't enough; NT Factor vs. urolithin A (Mitopure®️) for mitochondria; Alternatives to PPIs for Barrett's Esophagus; Topical—not oral—melatonin for skin rejuvenation.
In part two of this two-part series, Dr. Vikram Karnik and Dr. Lorraine Kalia discuss the preclinical data and epidemiological data that led us to the phase three study on exenatide. Show reference: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00161-8/abstract
Dr. Vikram Karnik talks with Dr. Lorraine V. Kalia about the potential role of GLP-1 receptor agonists in neurodegenerative diseases, the current state of research, preclinical evidence, and future directions for GLP-1 agonists. Read the related article in The Lancet. Disclosures can be found at Neurology.org.
In part one of this two-part series, Dr. Vikram Karnik and Dr. Lorraine Kalia discuss recent clinical trials on exenatide as a disease-modifying therapy for Parkinson disease. Show reference: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00161-8/abstract
In this episode of the Unreasonable Health Podcast, Cade Archibald kicks off The Ageless Brain five-part series, diving into the science of neuroinflammation, cognitive decline, and brain regeneration.He explores the role of peptides like Semax and Selank in reducing inflammation and enhancing neuroplasticity, alongside nootropics and lifestyle interventions that support brain health. Cade also introduces the NeuroCatch test, a cutting-edge tool for assessing cognitive function, and challenges listeners to engage in activities that boost neuroplasticity. Tune in to discover how to optimize your brain for longevity and peak performance!To optimize your brain, check us out! https://acueastwest.com/
This episode of Naked Neuroscience is co-published on the Naked Scientists Podcast. James Tytko examines one of the largest causes of disability amongst the young: multiple sclerosis. We hear from Lara Kingsman who is living with MS, doctors at the University of Cambridge take us inside the brain to help guide interventions, and the MS Society tell us about their innovative drug trial in collaboration with UCL to help find new treatments... Like this podcast? Please help us by supporting the Naked Scientists
In dieser spannenden Q&A-Folge spricht Olaf mit Wiederholungsgast Dr. Jonathan Apasu über Testosteron und Hormonersatztherapie (TRT). Dabei klären sie unter anderem:
Send us a textShort Summary: The complexities of neurodegenerative disease, particularly Alzheimer's, environmental influences like glyphosate, and the crucial role of nutrients like choline, with actionable insights into brain health management.About the guest: Dr. Ramon Valazquez is an Assistant Professor at Arizona State University, leading a research lab at the Neurodegenerative Disease Research Center. His work focuses on environmental factors related to Alzheimer's and other dementias, alongside developing therapeutic strategies.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and to everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Ramon Velazquez explores neurodegenerative disease, with a deep dive into Alzheimer's, its pathophysiology including amyloid beta plaques and tau pathology. It examines the controversy around these proteins' roles in disease progression, the influence of environmental toxins like glyphosate on brain health, and the preventive potential of nutritional interventions, particularly choline.Key Takeaways:Neurodegenerative Disease Basics: Alzheimer's disease involves both amyloid beta plaques and tau tangles, with tau pathology more closely linked to clinical symptoms.Environmental Impact: Glyphosate, a common herbicide, can cross into the brain, potentially exacerbating neurodegenerative pathways through inflammation.Choline: Essential for brain function and fat metabolism, it's often deficient in diets, particularly plant-based ones. Adequate intake might prevent or mitigate cognitive decline and related diseases.Preventive Measures: Early nutritional intervention, like maintaining choline levels, could be vital for preventing neurodegenerative diseases. However, once symptoms are present, such interventions might not reverse existing pathology.Related episode:M&M #145: Epigenetics, HormonesSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Use your phone's link. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Harness Therapeutics' CEO talked to In Vivo about the company's scientific strategy, and its plans for expansion and partnering in the neurodegeneration space.
Is Your Microbiome Sabotaging Your Health? I am joined by Kiran Krishnan as we delve into the fascinating world of gut health and probiotics! Kiran explains the crucial roles of different types of bacteria in maintaining gut health, the pitfalls of common probiotic supplements, and introduces us to spore-based probiotics and psychobiotics. He offers actionable insights into improving gut health through diet, exercise, and the right supplements. Kiran Krishnan is renowned research microbiologist and an expert in the human microbiome. With over two decades of experience in the field and has been at the forefront of groundbreaking research, focusing on the critical role our gut microbiome plays in overall health. Visit https://justthrivehealth.com and use code NAT20 for a discount. What We Discuss Understanding Gut Health and the Human Microbiome 00:27 The Role of Microbes in Digestive Health 01:11 Microbiome Diversity and Its Impact on Health 03:34 Challenges with Gut Testing Kits 04:23 Functional Redundancy in the Microbiome 05:29 Balancing Microbial Populations for Optimal Health 08:40 The Importance of Microbiome Diversity 10:10 Misconceptions About Pathogens in the Gut 11:23 The Impact of Modern Lifestyle on Gut Health 19:26 The Gut-Brain Connection 27:04 Inflammation and the HPA Axis 32:06 Neurodegeneration and Protein Misfolding 32:55 Impact of Endotoxins on Neurotransmitters 34:27 Gut-Brain-Liver Axis and Energy Balance 35:33 The Role of Sleep and BDNF in Brain Repair 40:44 Rising Prevalence of Neurological Disorders 41:51 Probiotics and Gut Health Solutions 43:57 The Importance of Fiber 54:04 Conclusion and Product Recommendations 01:00:48 Thank you to our sponsors for making this episode possible: Zona Health: Visit https://www.zona.com/ and use code NAT24 to save $100 on the purchase of a Zona Plus device Element Health Supply: Use code Lonevity when shopping at https://elementhealthsupply.com/discount/Longevity to save on your orders. SiPhox: Visit http://SiPhoxhealth.com/nat and save on your test. Find more from Kiran Krishnan & Just Thrive: Website: https://justthrivehealth.com Instagram: https://www.instagram.com/justthrivehealth/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Join Nat's Membership Community: https://www.natniddam.com/bsp-community Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0 Instagram: https://www.instagram.com/nathalieniddam/ Website: www.NatNiddam.com Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Key Take Aways: Gut health significantly impacts overall well-being, including mental health, cognitive function, and systemic health. Maintaining a balance of gut bacteria, which in turn supports metabolic, immune, and neurological health. Consuming a diverse diet rich in fibers helps promote this diversity. Consistent dietary and lifestyle changes are important for maintaining a healthy gut. Prebiotics are as important as probiotics feed beneficial bacteria and support a healthy microbiome.
Guest Michael Greicius is an authority on Alzheimer's disease. He makes the case that while effective treatments have remained elusive, there are high hopes for new approaches that target tau proteins in the brain associated with the disease. In the meantime, to reduce Alzheimer's risk stay active, eat well, and manage circulatory risks, but skip genetic testing for now until better treatments emerge, Greicius tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Michael GreiciusConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Michael Greicius, a professor of neurology and neurological sciences at Stanford University.(00:02:12) Understanding Alzheimer's DiseaseThe roles of amyloid and tau proteins in Alzheimer's disease.(00:04:53) Challenges in Developing TreatmentsThe multiple hurdles in creating Alzheimer's therapies.(00:09:07) Current Alzheimer's DrugsThe controversies and limitations of recently approved drugs.(00:10:23) Amyloid Plaques and Their ImpactWhy removing amyloid plaques hasn't improved patient outcomes.(00:14:29) Problems with Alzheimer's TrialsThe disconnect between amyloid removal and patient outcomes.(00:18:03) Functional Unblinding and Trial BiasHow functional unblinding affects trial results and drug evaluations.(00:23:51) The Potential of Targeting TauNew breakthroughs in targeting tau protein for Alzheimer's.(00:26:35) The Future of PreventionPotential preemptive treatments for Alzheimer's and their administration.(00:29:19) Lifestyle and Risk ReductionRecommendations for reducing risk of Alzheimer's disease.(00:31:43) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook
In this episode of the Health Detective Podcast by Functional Diagnostic Nutrition, the focus is on the cGAS-STING signaling pathway and its role in driving age-related inflammation and neurodegeneration. Dr. Gonshor delves into recent research revealing how this pathway, usually responsible for immune defense, contributes to chronic inflammation and functional decline during aging. Where to find more about FDN: fdntraining.com/resources.
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
In this episode, I interview Dr. Ken Sharlin, a neurologist and the author of The Healthy Brain Toolbox, to discuss Parkinson's disease and other neurodegenerative conditions like Alzheimer's and ALS. Dr. Sharlin explores the symptoms, causes, and potential breakthroughs in treating these diseases through both conventional and functional medicine.What We Discuss:Parkinson's Symptoms and Early Signs: Both motor symptoms (such as tremors, rigidity, and shuffling gait) and non-motor symptoms (including anxiety, depression, constipation, and REM sleep behavior disorder) can appear during a pre-motor phase that may last over a decade before diagnosis. The Neuroscience of Parkinson's: We explore how dopamine loss and damage to the basal ganglia disrupt movement, highlighting the role of dopamine in the disease's hallmark symptoms.Current Treatments: While there's no cure, treatments like levodopa manage symptoms. Diagnostic tools like DAT and SPECT scans reveal brain abnormalities that guide treatment.Levodopa: This vital medication helps restore dopamine but can cause side effects like psychosis, making it important to balance with functional approaches. Explore its science, benefits, risks, and limitations. Environmental Factors: Toxins, head injuries, and gut health may contribute to Parkinson's, with inflammation and oxidative stress playing key roles in its development.Gut-Brain Connection: We discuss how gut health affects brain function and the potential of diet and probiotics to slow disease progression.Diet and Lifestyle: A plant-based, anti-inflammatory diet, along with sleep, exercise, and stress management, is crucial for brain health and reducing inflammation.Understanding Systems Biology: We explore systems biology and how our interconnected bodily systems influence neurodegenerative diseases like Parkinson's, advocating for a holistic strategy instead of just treating individual organs or symptoms. Reversing Cognitive Decline: Dr. Sharlin shares success stories of reversing Alzheimer's through functional medicine, emphasizing the importance of lifestyle changes and controlling inflammation.RESOURCESBOOKS- An Essay on the Shaking Palsy by James Parkinson- The Healthy Brain Toolbox by Dr. Ken Sharlin- Why Zebras Don't Get Ulcers by Robert Sapolsky DRUGS- Aducanumab (Aduhelm)- Donanemab (Kisunla)- Fluoxetine (Prozac)- Omeprazole (Prilosec, Losec)- Lecanemab (Leqembi) - Levodopa and Carbidopa (Sinemet)MOVIES & TV- Awakenings- Star Trek- Supersize MePEOPLE- Barbara Pickut- Brett Favre- Hans Selye- James Parkinson- Leonardo da Vinci- Morgan Spurlock- Robert Sapolsky- Robin Williams- Robert De Niro- Walter CannonORGANIZATIONS- Bened Life- Biogen- Eli Lilly- Eisai - Green Bay Packers- The Institute for Functional Medicine- University of MichiganVOCABULARY- Alpha-synuclein- Amyloid- Cytochrome P450- Cytokines- Electron transport chain- General Adaptation Syndrome (GAS)- Glutathione- Glycolysis- Krebs Cycle - Lateral ventricles- Montreal Cognitive Assessment- Normal pressure hydrocephalus (NPH)- mTOR pathway- Peroxide- Postencephalitic Parkinsonism - Superoxide- Tau PET imaging- Trichloroethylene- Urea cycleConnect & Learn MoreWebsite: functionalmedicine.doctor Book: healthybraintoolbox.com
In this episode, we dive into the role of microglial cells, the brain's resident immune defenders, and how their chronic activation at the cellular level contributes to neurodegeneration. We'll explore the cellular mechanisms behind microglial activation, including the involvement of P2Y12 receptors and the release of pro-inflammatory cytokines like IL-1β and TNF-α. Additionally, we'll discuss how everyday environmental toxins and stressors can trigger long-term microglial activity, potentially increasing the risk of conditions like Alzheimer's. Topics: 1. Introduction - Overview: Microglia and neurodegeneration. - Environmental toxins affecting microglia. 2. Brain and Microglial Overview - Brain has neurons and glial cells. - Microglia are the brain's immune cells. - Roles: Immune defense, synaptic pruning, neuroprotection. 3. Microglial Immune Function - Constantly monitor for infection and damage. - Activated microglia perform phagocytosis. - Clear debris and maintain brain health. 4. Cellular Mechanisms of Activation - P2Y12 receptors respond to ATP/ADP. - Microglia shift from resting to activated. - Activated microglia are highly phagocytic. 5. Role in Synaptic Pruning - Microglia help in synaptic pruning. - Remove weak synapses for efficient brain circuits. 6. Microglia in Neurodegeneration - Chronic activation leads to inflammation. - Release of cytokines like IL-1β, TNF-α, IL-6. - Contributes to Alzheimer's, Parkinson's. - MHC molecules 7. Environmental Toxins and Activation - Mycotoxins cross BBB and activate microglia - Heavy metals like lead, aluminum affect neurons - Pesticides/herbicides linked to Parkinson's risk 8. Other Factors Activating Microglia - Industrial chemicals, BPA - Artificial additives, alcohol - Chronic stress 9. Conclusion - Recap: Microglial functions and overactivation. - Lifestyle factors influence microglial health. Thank you to our episode sponsors: 1. Check out Daily Nouri and use code CHLOE20 for 20% off your order. 2. Check out the TruAge Biological Age Test from TruMe Labs. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Dr. Brandon Brock and I had a fascinating discussion about how inflammation is a key factor in neurodegenerative diseases. We explored how factors like diet, the environment, and post-COVID effects can worsen these conditions. Together, we emphasize the importance of a holistic treatment approach—combining diet, lifestyle adjustments, and innovative therapies like low-level laser therapy to improve outcomes. We also dive into exciting topics like the gut-brain axis, immune resilience, and the transformative potential of functional neurology. You don't want to miss this one! Key Takeaways: Impact of Inflammation on Neurodegeneration: Chronic inflammation significantly contributes to neurodegenerative diseases, making immune modulation essential. Role of the Gut-Brain Axis: The health of the gut directly affects brain function, illustrating the importance of holistic treatments. Post-COVID Inflammatory Burden: Long COVID acts as a catalyst for inflammation, affecting multiple organ systems, especially the brain and heart. Innovative Therapies: Non-thermal, low-level laser therapy can improve cellular function and reduce inflammation. Food as Medicine: Diet plays a critical role in preventing neurodegenerative diseases and overall health maintenance. More of Dr. Brandon Brock: Dr. Brandon Brock is a highly accomplished clinician and educator. He serves as a Staff Clinician at Carpathia Wellness and a Clinical Educator at Erchonia Medical. He holds a Doctorate of Nursing Science (Ph.D.) from Texas Woman's University, a Doctorate of Nursing Practice (D.N.P.) from Duke University, and a Doctorate of Chiropractic (D.C.) from Parker University. Dr. Brock is also a post-doctoral global clinical research scholar at Harvard Medical School. His dedication to bringing hope to those who are sick is a driving force in his work. With a Master's in Nursing Science, specializing in Family Nursing Practice (ACNB - FNP-C) from Samford University and an Orthopedic Advanced Practice Specialization from Duke University, Dr. Brock is highly credentialed. He is a Diplomate of the American Chiropractic Neurology Board and the Chiropractic Board of Clinical Nutrition. Additionally, he holds fellowships in Stem Cell Therapy from the American Academy of Anti-Aging Medicine, the American College of Functional Neurology, and the International College of Chiropractors. He also serves as the Vice Chair of the Pediatric Acute-Onset Neuropsychiatric Syndrome Advisory Council for Texas. Beyond his professional achievements, Dr. Brock has four exceptional children. His wife, Tara Brock, is an outstanding health coach who collaborates with him in patient care and is his life partner, bringing immense joy. They love traveling, staying active, and spending time with friends worldwide. They passionately support health, faith, wellness, and living a fulfilled life. Their shared mission is to bring hope to those who are sick and have lost their way. Website Instagram Connect with me!: Website Instagram Facebook YouTube
In this episode, we have the privilege of speaking with Dr. Michael Lewis, renowned expert in brain health and traumatic brain injury (TBI), and author of the groundbreaking book, When Brains Collide. Dr. Lewis is the founder of the Brain Health Education and Research Institute and BrainCARE. With a military background and extensive experience in traumatic brain injuries, Dr. Lewis has dedicated his career to exploring how omega-3 fish oils can play a vital role in preventing and recovering from concussions, TBI, stroke, and neurodegenerative diseases. Key Discussion Points 1. The Role of Omega-3 Fish Oils in Brain Health Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA), the primary omega-3 fatty acids found in fish oil, are crucial for maintaining brain structure and function. Omega-3s are anti-inflammatory and neuroprotective, making them vital in protecting the brain from injury and supporting recovery. 2. High-Dose Omega-3 Fish Oil for Concussions and Traumatic Brain Injury (TBI) Dr. Lewis emphasizes how high-dose fish oil can help mitigate damage following a concussion or TBI. Dosing Protocols: In acute brain injury cases, Dr. Lewis recommends significantly higher doses of fish oil (e.g., up to 3-9 grams of combined DHA and EPA per day) to reduce inflammation, promote healing, and restore brain cell membrane integrity. Case studies demonstrate remarkable improvements in TBI patients, including quicker recovery times, reduced brain fog, and restored cognitive function. 3. Fish Oils for Neurodegeneration and Stroke Prevention Regular intake of omega-3s is shown to be effective in reducing the risk of neurodegenerative diseases like Alzheimer's and Parkinson's. Omega-3s help prevent stroke by reducing blood clot formation, improving vascular health, and lowering inflammation in brain tissues. Dr. Lewis advocates for omega-3s as part of a preventive strategy, particularly for aging individuals at higher risk of neurodegenerative conditions. 4. Using Omega-3s as Preventive Medicine Consistent omega-3 supplementation is not just for recovery—it's crucial for maintaining optimal brain health. Athletes, military personnel, and individuals at risk for head trauma should use omega-3s proactively to strengthen their brain's resilience to injury. Preventative Dosing: Dr. Lewis suggests a daily intake of at least 2-3 grams of DHA and EPA combined for ongoing brain health and injury prevention. 5. How to Choose a High-Quality Fish Oil Dr. Lewis explains the criteria for identifying a high-quality fish oil supplement: Purity: Free from contaminants like heavy metals and toxins. Potency: Look for a high concentration of DHA and EPA. Stability: Avoid fish oils that oxidize easily, as rancid oils can be harmful. Sourcing: Prefer fish oils sourced from wild-caught, sustainably harvested fish. Importance of third-party testing to ensure the product is safe and effective. 6. Personal Stories and Case Studies Dr. Lewis shares inspiring stories of patients and athletes who have successfully used omega-3 therapy to recover from brain injuries. Examples include a football player who recovered from multiple concussions and a stroke survivor who regained cognitive function with high-dose omega-3 supplementation. 7. How to Use Omega-3s After Brain Injury Immediate supplementation following a brain injury can make a significant difference in recovery outcomes. The sooner omega-3s are introduced post-injury, the better. Dr. Lewis provides insight into the timing and administration of omega-3 supplements during the acute phase of brain injury treatment. Recommended Resources: Dr. Michael Lewis's Website: Brain Health Education and Research Institute: http://www.brainhealtheducation.org/ BrainCARE: BrainCARE Center When Brains Collide Book Join us for this enlightening discussion on the powerful benefits of omega-3 fish oils for brain protection, recovery, and overall health. Dr. Michael Lewis's pioneering work is transforming how we approach brain injuries and neurodegeneration, highlighting the critical role that nutrition and supplementation play in maintaining cognitive vitality. Tune in to learn how you can harness the power of omega-3s for your brain health and optimize your recovery from injury or disease. BIO Michael Lewis, MD, MPH, MBA, FACPM, FACN, is a proven leader and expert in the treatment and management of concussions and brain injuries. He also applies his holistic approach to Men's Health and outpatient orthopedics. Upon retiring as a Colonel in the U.S. Army, he founded the nonprofit Brain Health Education and Research Institute and entered private practice focusing on helping patients with chronic concussion issues. His pioneering work in the military and since has helped thousands of people around the world and he is regularly featured in the media, radio, podcasts, webinars, scientific conferences, and television. A lifelong athlete, Dr. Lewis serves on the Pop Warner Youth Football Medical Advisory Board and Board of Directors of National Collegiate Rugby where is also the head of the Medical and Safety Committee. Dr. Lewis is the author of When Brains Collide: What Every Athlete and Parent Should Know About the Prevention and Treatment of Concussions and Head Injuries. He is a graduate of the U.S. Military Academy at West Point and Tulane University School of Medicine. He is board- certified and a Fellow of the American College of Preventive Medicine and American College of Nutrition. He completed post-graduate training at Walter Reed Army Medical Center, Johns Hopkins University, and Walter Reed Army Institute of Research. Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with: Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen, intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals Nutristat Omega 3 to 6 status and more Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission. Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to https://www.buymeacoffee.com/LisaT to donate $3 Lisa's Anti-Aging and Longevity Supplements Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world. This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life. Subscribe to our popular Youtube channel with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge" Check them all out at https://shop.lisatamati.com/collections/books Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here: Use code "tamati" at checkout to get a 10% discount on any of their devices. 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In the past few years, Big Pharma has released not one, but three new treatments for Alzheimer's disease. Aducanemab (2021), Lecanemab (2023), and Donanemab (2024), are the first treatments to effectively clear the brain of amyloid plaques — the sticky protein clumps whose build-up in the brain has defined the disease for decades. The problem? They may not help patients at all.Today's guest, Stanford neurologist Mike Greicius, considers the new amyloid-clearing drugs a major disappointment — and worse, says they likely do more harm than good for patients.Despite this critique, Greicius, thinks that the next few years will be an exciting time for novel Alzheimer's therapies, as growing biological understanding of Alzheimer's risk and resilience bear fruit with promising new approaches to treatment.Learn More:Greicius is the Iqbal Farrukh and Asad Jamal Professor of Neurology and Neurological Sciences at Stanford Medicine, and a member of the Knight Initiative for Brain Resilience and Alzheimer's Disease Research Center at Stanford University.Amyloid Drug Skepticism:Substantial Doubt Remains about the Efficacy of Anti-Amyloid Antibodies(Commentary, Journal of Alzheimer's Disease, 2024)New Drug Approved for Early Alzheimer's (New York Times, 2024)Alzheimer's drug adoption in US slowed by doctors' skepticism (Reuters, 2024)One step back: Why the new Alzheimer's plaque-attack drugs don't work (Stanford Medicine Scope Blog, 2024)Alzheimer's Genetics Research:Knight-funded research uncovers gene mutations that may prevent Alzheimer's Disease (Knight Initiative for Brain Resilience, 2024)Why is a common gene variant bad for your brain? (Stanford Medicine Magazine, 2024)Scientists find genetic Alzheimer's risk factor tied to African ancestry (Stanford Medicine, 2023)Episode CreditsThis episode was produced by Michael Osborne, with production assistance by Morgan Honaker, and hosted by Nicholas Weiler. Art by Aimee Garza.Send us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.
*A disclaimer that there will be discussions of self harm in this episode* In 2003, Chris Nowinski found himself in a WWE wrestling ring, concussed and not remembering where he was or how he was supposed to finish the match. This would be a pivotal moment not just in his life but for an entire field of research on a neurodegenerative disease long known to exist but poorly defined and even censored: chronic traumatic encephalopathy or CTE. There's evidence that people knew about CTE — which went by names like “punch drunk” — starting in the 1920s, but it wasn't until the 2000s, when American football players began being diagnosed with CTE post-mortem, that the disease started gaining public traction. Many of those football players, including Andre Waters, had died by suicide. Chris, now a behavioral neuroscientist and the co-founder and CEO of the Concussion Legacy Foundation, pushed to get the brains of Waters and other athletes tested, and began spreading awareness and putting pressure on organizations like the NFL to acknowledge the devastation this disease can bring to athletes and their families.Today on the show we will cover what's known about CTE and how to prevent it, and how researchers are trying to find ways of diagnosing it in people who are still alive and working to find treatments.Here are some good CTE resources:https://concussionfoundation.org/CTE-resources/support https://www.bu.edu/cte/resources/resources-for-families/Send us your science stories/factoids/news for a chance to be featured on an upcoming Tiny Show and Tell Us episode and to be entered to win a Tiny Matters coffee mug! And, while you're at it, subscribe to our newsletter at bit.ly/tinymattersnewsletter.Links to the Tiny Show & Tell stories are here and here. All Tiny Matters transcripts and references are available here.
Pain isn't nice, but there are times when it's necessary - If you don't feel the pain you should, you're at risk of doing yourself greater damage. If you feel pain you shouldn't, that could the first signs of a deeper issue. Professor Rayaz Malik and Dr Ioannis Petropolous talk about their work on a new, non-invasive, inexpensive way of detecting early stages of neurodegeneration that could be as easy as an opticians appointment. Read their original research: https://doi.org/10.2337/dc20-2012
What can you do today to improve or maintain your brain health? Sarah Banks, Ph.D., an expert in healthy aging, dementia, and Alzheimer's disease, explores risk factors and corrective tips associated with sleep apnea. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40042]
What is low vagal tone and why have studies linked it to people with autism spectrum disorders? Learn 5 ways you can easily stimulate the vagus nerve at home, and how it can help both you and your child to improve Digestion, Calming, and Overall Better Health. The vagus nerve is the longest cranial nerve in the body branching out from the brain to different areas of the body. It not only regulates gut physiology, but is also involved in controlling the cardiovascular, respiratory, immune, digestive, and endocrine systems. It has a tremendous connection with our ability to stay calm. This is because the vagus nerve is intimately connected with the parasympathetic nervous system. Children with autism commonly display symptoms of vagus nerve dysregulation. Resetting the vagus nerve can help to create what is called vagal calm in the body. The vagus nerve is important to address at the beginning of any detoxification protocol since detoxifying is an additional stressor. The vagus nerve may need to be reset to optimize the autonomous nervous system to eliminate inappropriate fear responses, whether fight or flight, or an immobility shutdown response. This is commonly seen in symptoms such as heart arrhythmias. Neurodegeneration of the vagus nerve comes from intestinal disorders, environmental toxic exposure, coinfections, inflammation, or any physical or emotional trauma that cause continual stress on the body. The vagus nerve can get stuck in the fight or flight response and create anxiety-like behaviors, as well as depressive ones. It also has to do with our ability to connect to others. This will be discussed a bit later... Click Here or Click the link below for more details! https://naturallyrecoveringautism.com/200
In today's episode of The Root Cause Medicine Podcast, we navigate the importance of brain health and preventing cognitive decline with Louisa Nicola. You'll hear us discuss: 1. How women in their 30s and 40s can prevent Alzheimer's 2. Why exercise is the best preventive tool against Alzheimer's disease 3. The surprising benefits of resistance training for your brain health 4. Nutrition insights for enhancing brain health 5. Why the best thing for a healthy aging brain is social connections Louisa is a neurophysiologist and human performance coach. She is the Founder of Neuro Athletics, a consulting firm that works with top athletes worldwide, leveraging EEG scans, lab tests, and cognitive assessments to optimize performance. Louisa's insights delve deep into the minds of elite NBA and MLB stars. Additionally, she serves on the board of Momentous, Tonal, and Klora. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide
The average age of onset for mild cognitive impairment is not 65, not even 50, but a staggering 47 years old. And that's just the tip of the iceberg. The projected statistics for Alzheimer's by 2030 are downright alarming. But what is causing this rise in neurodegenerative diseases? Dive into this eye-opening conversation about the impact your epigenetics, ancestral lineage, and environment all have on your cognitive health. Uncover the surprising factors that could be shaping our health and the proactive steps you can take to safeguard your brain. In this episode, Dr. Greg Eckel discusses the concerning rise of neurodegenerative diseases and their impact on brain health. If you're looking to understand and take charge of your brain health, this insightful conversation is a must-listen for valuable knowledge and actionable steps. Listen now to start taking care of your brain today! Follow us on Instagram at https://www.instagram.com/feelfreakingamazing/ Show notes Dr. Eckel shared eye-opening statistics, revealing the projected significant increase in dementia and Alzheimer's cases by 2030. He emphasized the influence of the specific factors contributing to this rise. He also delved into the lasting effects of trauma and the concept of epigenetics, highlighting the interplay of genes, environment, and experiences in shaping health outcomes. By understanding the impact of epigenetics on gene expression and its connection to neurodegenerative diseases, Dr. Eckel provided valuable insights into the proactive management of brain health through lifestyle changes. Impact of environmental toxins Unprecedented levels of toxins in the environment contribute significantly to the increase in neurodegenerative diseases. In addition, declining soil nutrients further exacerbate the impact of environmental toxins on brain health. Awareness and action are essential to address the role of environmental factors in the rise of these diseases. Early signs of neurodegenerative diseases Early onset of mild cognitive impairment can begin as young as 47 years old, signaling potential dementia or Alzheimer's. By 2030, projections indicate that half of adults over 65 may develop some form of neurodegenerative disease. The rise in these diseases at younger ages highlights the need for an active approach to preventing these outcomes. Role of nutrition in prevention Nutritional factors play a crucial role in preventing neurodegenerative diseases. - Proper diet, stress management, and lifestyle choices can mitigate the risk of these diseases. - Understanding the importance of nutrition in brain health is key to empowering individuals to make proactive choices for their well-being. Guest Bio In practice since 2001, Dr. Gregory Eckel co-founded Nature Cures Clinic in Portland, Oregon, where he shares what he calls "Sarieah's gifts" with the world. As a loving husband and clinician, he took a deep dive into medical research looking for cures to his wife's Creutzfeldt-Jakob disease, a rare, chronic neurodegenerative condition with no known cure. While he didn't find a solution for Sarieah, the information he discovered and now uses in his clinic is showing promise for thousands of people and their brain health. Links Instagram Facebook Youtube naturecuresclinic.com/ Clear Mind Nasal Spray: https://naturecuresclinic.com/clearmind Book: Shake It Off https://naturecuresclinic.com/book Tests: https://www.tzarlabs.com/ https://www.galleri.com/ Related Episodes Lower Your Risk for Cancer & Chronic Diseases, with Dr. Greg Eckel Identify Neurodegeneration Early, with Dr. Greg Eckel Optimize Your Brain, with Dr. Patrick Porter Heal the Gut-Brain Connection, with Dr. Will Cole Detox Your Mind-Body System, with Dr. Issac Eliaz Decrease Toxic Exposure and Become More Resilient, with Dr. Joseph Pizzorno Detox from Heavy Metals, with Wendy Myers Detox to Reverse Disease, with Dr. Joseph Pizzorno Reduce the Toxins in Your House, with Dr. Vivian Chen Upgrade Your Heavy Metal Detox, with Wendy Myers Personalize Your Detox, with Dr. Mark Hyman
Send us a Text Message.Dr. Greg Eckel, a naturopathic physician and Chinese medicine practitioner, shares his journey and work in brain regeneration and longevity. He was inspired to pursue this path after witnessing the over-medication of children with attentional issues. Dr. Eckel's protocol, called the ECHO protocol, combines ancient wisdom with cutting-edge therapeutics, including frequency medicine, stem cells, hyperbaric oxygen, and acupuncture. He emphasizes the importance of understanding the energetic and epigenetic components of health and healing. Dr. Eckel's work has shown promising results in improving the quality of life for patients with neurodegenerative conditions like Parkinson's disease.Dr. Greg Eckel discusses the need for a more integrative approach to treating neurodegenerative diseases like Parkinson's. He emphasizes the importance of addressing the underlying causes of these conditions, such as gut health, toxicity, chronic infections, and hormonal imbalances. Dr. Eckel also highlights the role of love and intention in healing and the need for a heart-centered approach to medicine. He shares success stories of patients who have experienced significant improvements in their symptoms through his integrative protocols. Dr. Eckel's book, 'Shake It Off: An Integrative Approach to Parkinson's Solutions,' provides further insights into his approach.What You'll LearnDr. Greg Eckel's journey in brain regeneration and longevity was inspired by witnessing the over-medication of children with attentional issues.His ECHO protocol combines ancient wisdom with cutting-edge therapeutics, including frequency medicine, stem cells, hyperbaric oxygen, and acupuncture.Understanding the energetic and epigenetic components of health and healing is crucial for effective treatment.Dr. Eckel's work has shown promising results in improving the quality of life for patients with neurodegenerative conditions like Parkinson's disease. A more integrative approach is needed to treat neurodegenerative diseases like Parkinson's, addressing underlying causes such as gut health, toxicity, chronic infections, and hormonal imbalances.Love and intention play a significant role in healing, and a heart-centered approach to medicine is essential.Success stories of patients experiencing significant improvements in symptoms through integrative protocols highlight the potential of this approach.Dr. Eckel's book, 'Shake It Off: An Integrative Approach to Parkinson's Solutions,' provides further insights into his approach.Ideas Worth Sharing"There's gotta be a better way to treat children with attentional issues.""We need to think about a garden... Is it getting enough sunlight? Is it getting enough nutrients? Is it getting enough water? It's the same thing with us.""Our nervous system has an extremely intimate connection with light.""Why do we only pour billions and trillions of dollars into pharmaceuticals when there is a 95% success rate in treating Parkinson's and neurodegenerative diseases through integrative approachProducts 528 Innovations Lasers NeuroSolution Full Spectrum CBD NeuroSolution Broad Spectrum CBD NeuroSolution StimPod Learn MoreFor more information, resources, and podcast episodes, visit https://tinyurl.com/3ppwdfpm
On today's solo episode....Neurodegeneration and brain aging affect millions worldwide, with numbers expected to triple by 2050. While pharmaceuticals offer limited solutions, lifestyle choices, especially exercise and diet, are vital for brain health.Study 1: Chronic Inflammation and Cognitive Performance The CARDIA study tracked inflammation in young adults and found chronic inflammation can impair midlife cognitive performance. Participants with high CRP levels were significantly more likely to have poor processing speed and executive function. Early management of inflammation is crucial for cognitive health.Study 2: Smoking and Cognitive Decline A Nature Communications study of 32,000 adults revealed smoking accelerates cognitive decline by up to 85% over 10 years. Smokers who adopted healthy behaviors like exercise and socializing had cognitive decline rates similar to non-smokers, highlighting the importance of quitting smoking and healthy living.Study 3: Diets Rich in Omega-3s and Antioxidants A study found older adults with diets rich in omega-3s, antioxidants, and vitamins show slower brain aging and better cognitive function. Nutrients like alpha-linolenic acid, EPA, lutein, zeaxanthin, vitamin E, and choline are crucial for brain health, emphasizing the role of diet in cognitive maintenance.Sponsors:ZocDoc- Use code NEURO - https://www.zocdoc.com/neuroBioProtein Technology - Use code LOUISA to save 10% - https://www.bioproteintech.com/shop/biopro-plus-cortisleepStudies:1. Inflammation2. Smoking3. Diet & Brain Health#Alzheimersdisease #dementia #brainhealth #diet #omega3 #antioxidantsThe Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner.
In the 3rd hour of the Marc Cox Morning Show: Dr. Tom Pitts, on NBC News, says he thinks Biden has neurodegeneration Cody Sargent with Heritage Action for America, joins Marc & Kim to discuss Trump's and the GOP's platform. Jason Isaac, CEO of The American Energy Institute an former Texas Representative, talks with Marc & Kim on the fragility of renewable energy and what that means for the victims of Hurricane Beryl Kim on a Whim, too! Coming Up: Charles Payne
Imagine a world where the foods we eat daily are quietly eroding our brain's capabilities, silently accelerating the aging process of our most vital organ. Recent groundbreaking studies have unveiled the shocking impact of ultra-processed foods on our brain health, revealing significant reductions in gray matter volume and white matter integrity.This isn't science fiction—this is our reality. As bad as this sounds and is, the good news is, we can turn this around and actively not only stop the damage to our brain, but heal it and optimize it.Our guest today is a globally recognized expert whose work has revolutionized our understanding of brain health and the critical role of diet in neurological function. We are honored to speak with Dr. David Perlmutter, a board-certified neurologist and Fellow of the American College of Nutrition.He is the author of several New York Times bestselling books, including "Grain Brain," which has sold over a million copies worldwide, and his latest, "Drop Acid," which explores the surprising role of uric acid in metabolic diseases. Dr. Perlmutter's extensive research and groundbreaking findings have been published in esteemed journals such as the Journal of Alzheimer's Disease, Archives of Neurology, and Neurosurgery.Dr. Perlmutter's research has been a beacon of hope, offering practical, science-backed strategies for enhancing brain health and preventing neurodegenerative diseases.Today, we will delve into how ultra-processed foods contribute to cognitive decline and brain structure changes, explore the gut-brain axis's profound impact on neurological health, and discuss innovative preventative strategies for conditions like Alzheimer's.In a world where chronic diseases and cognitive decline are on the rise, Dr. Perlmutter's insights offer a beacon of hope and practical guidance. Whether you're concerned about your brain health, seeking to enhance cognitive resilience, or looking for the latest scientific breakthroughs in neurology, this conversation is packed with invaluable information.In my conversation with Dr. Perlmutter, you'll discover:-How our hectic lifestyles are deleteriously affecting the "happy" side of our brain...02:50-If we were all sleeping well, moving adequately and eating nutritious whole foods, we would not see a lot of this strife and against each other...08:12-Case study in processed foods having an immediate effect on the health of the brain...12:40-Current trends in the diagnosis and treatment of Alzheimers and Parkinson's diseases...18:01-What else besides diet is affecting inflammation levels in our bodies?...22:00-Introducing the iboga plant and its use in current treatments of neurological issues...29:58-Dr. Perlmutter's thoughts on ketamine and MDMA in treating PTSD...34:30-How does the semen microbiome influence sperm quality and fertility...40:43-Why you should think twice about delivering via C-section!...46:23-And much more...Resources mentioned:Dr. Perlmutter's websiteBooks authored by Dr. PerlmutterSOCIAL MEDIAInstagramFacebookYouTubeP.S. If you enjoy this episode and feel it helps to elevate your life, please give us a rating or review. And if you feel others may benefit from this podcast as well, spread the word, share and help grow our tribe of Superhumans. When we help heal One, we help heal All. Much gratitude and...
Are you concerned about how aging might impact your brain health or immune system? Have you ever wondered how your gut health plays a role in neurodegeneration? If so, this episode of the Dr. Jockers Functional Nutrition Podcast is a must-listen. Dr. Peter Kan, a leading expert in functional medicine, joins us to delve into the fascinating connection between the brain, immune system, and gut, and how this triad influences aging and neurodegenerative diseases. In this episode, we explore the concept of "inflammaging," the role of mitochondria in maintaining brain health, and practical strategies you can implement to support your brain-immune-gut axis for optimal health and longevity. Discover actionable insights that will help you tackle inflammation, improve cognitive function, and maintain a healthy immune system as you age. In This Episode: - 00:00 Introduction to Ischemic Dementia - 00:26 Welcome to the Dr. Jockers Functional Nutrition Podcast - 02:50 Interview with Dr. Peter Kan: Brain-Immune-Gut Connection - 04:23 Understanding the Brain-Immune-Gut Axis - 04:47 The Role of Inflammation in Aging - 10:19 Fuel Delivery and Metabolism - 15:29 Neurodegenerative Diseases and Their Causes - 23:28 Impact of Gut Health on Cognitive Function - 26:45 Strategies for Maintaining Brain-Immune-Gut Health - 32:13 Conclusion and Where to Find More Information This podcast is sponsored by ShopC60.com. C60 is a powerful, Nobel Prize-winning antioxidant, that helps to optimize mitochondrial function, fights inflammation, and neutralizes toxic free radicals! I'm a big fan of using C60 in conjunction with your keto and intermittent fasting lifestyle to support your immune system, help your body detox, and increase energy and mental clarity. My favorite C60 products for Keto & IF lifestyles include C60 Purple Power in Organic MCT Coconut Oil (you can add this to your coffee) and their delicious Sugar-Free C60 Gummies (made with allulose and monk fruit)! If you are over the age of 40, and you'd like to kick fatigue and brain fog to the curb this year, visit shopc60.com and use the coupon code “JOCKERS” for 15% OFF and start taking back control over your health today! Have you heard of Paleovalley's amazing Turmeric Complex? It contains whole food and organic turmeric instead of just isolated curcumin. And we know that organic turmeric is way better, and one of the best things you can take to shut down inflammation in the body and support healthy blood flow and blood pressure. It also includes coconut oil and black pepper as its ingredients, which has been shown to improve the absorption of turmeric by 2000%! Plus, there's also organic ginger, rosemary, and cloves which synergize with the turmeric to help improve digestion and blood sugar. Paleovalley's Turmeric Complex also supports joint health, mental clarity, and improved brain function. You've just got to try this product. Visit paleovalley.com/jockers! “The Vagus Nerve is a Major 2 Way Communication Link Between the Brain and the Gut.” -Dr. Jockers Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio Resources: Visit https://shopc60.com/jockers – Use code “JOCKERS” to get 15% off! Paleovalley's Turmeric Complex - visit paleovalley.com/jockers Connect with Dr. Peter Kan: Website - https://askdrkan.com/ Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
In this episode, my guest is Dr. Gary Steinberg, MD, PhD, a neurosurgeon and a professor of neurosciences, neurosurgery, and neurology at Stanford University School of Medicine. We discuss brain health and brain injuries, including concussion, traumatic brain injury (TBI), stroke, aneurysm, and transient ischemic attacks (TIA). We discuss key and lesser-known risk factors for brain health and explain how certain treatments and medications can improve brain health and cognitive function. We also cover novel mechanisms to improve recovery after concussions and brain injury, including the use of stem cells, temperature (mild hypothermia), and vagus nerve stimulation. Dr. Steinberg also describes new advances in neurosurgery and minimally invasive brain augmentation. This episode ought to be of interest to anyone seeking actionable tools to improve their brain health and for those seeking to improve recovery after a brain injury such as concussion, stroke, aneurysm, or TBI. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman ROKA: https://roka.com/huberman AeroPress: https://aeropress.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Gary Steinberg 00:01:44 Sponsors: Eight Sleep, ROKA & AeroPress; Subscribe on YouTube, Spotify & Apple 00:06:16 Stroke, Hemorrhage & Blood Clot 00:10:25 Blood Clots & Risk Factors, Medications, Smoking, Cholesterol 00:16:19 Heart & Brain Health; Neurosurgery & Brain Function 00:23:27 Current Technology & Neurosurgery, Minimally Invasive Techniques 00:28:13 Transient Ischemic Attacks (TIA); Spinal Cord Strokes 00:33:23 Stroke Risk: Alcohol, Cocaine & Other Drugs 00:38:24 Sponsor: AG1 00:39:55 Traumatic Brain Injury (TBI), Concussion: Sports, Testing & Recovery 00:46:45 Statins; TBI & Aspirin; Caffeine & Stroke Risk 00:48:31 Exploratory MRI: Benefits & Risks 00:51:53 Blood Pressure, Lifestyle Factors; Tool: Feeling Faint, Hydration; Sleep 00:59:52 Sponsor: LMNT 01:01:27 Chiropractic Neck Adjustment & Arterial Obstruction; Inversion Tables 01:05:16 Kids, Tackle Football, Soccer, Boxing; Mild Concussion 01:10:49 Nerve Regeneration, Stem Cells, Stroke Recovery 01:17:36 Stem Cells, Immune System, Activity 01:21:27 Injury & Recovery, Restraint Therapy 01:23:46 Neuroprotection After Injury; Mild Hypothermia 01:34:59 Platelet-Rich Plasma (PRP), Stem Cell Therapy 01:42:27 Scientific Advancements & Clinical Translation, FDA & Industry 01:47:40 Vagal Stimulation 01:53:17 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
In this episode, my guest is Dr. E.J. Chichilnisky, Ph.D., professor of neurosurgery and ophthalmology at Stanford University, studying how we see and use that information to build artificial eyes to restore vision to people who are blind. We discuss how understanding the retina (the light-sensing brain tissue that lines the back of our eyes) is critical to knowing how our brain works more generally. We discuss brain augmentation with biologically informed prostheses, robotics, and AI and what this means for medicine and humanity. We also discuss E.J.'s unique journey into neuroscience and how changing fields multiple times, combined with some wandering, taught him how to guide his decision-making in all realms of life. This episode ought to be of interest to anyone interested in learning how the brain works, from a world-class neuroscientist to the future of brain therapeutics and to those seeking inspiration and tools for navigating their own professional and life journey. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman ROKA: https://roka.com/huberman BetterHelp: https://betterhelp.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Dr. E.J. Chichilnisky (00:02:31) Sponsors: Eight Sleep, ROKA & BetterHelp (00:06:06) Vision & Brain; Retina (00:11:23) Retina & Visual Processing (00:18:37) Vision in Humans & Other Animals, Color (00:23:01) Studying the Human Retina (00:29:48) Sponsor: AG1 (00:31:16) Cell Types (00:36:00) Determining Cell Function in Retina (00:43:39) Retinal Cell Types & Stimuli (00:49:27) Retinal Prostheses, Implants (01:00:25) Artificial Retina, Augmenting Vision (01:06:05) Sponsor: InsideTracker (01:07:12) Neuroengineering, Neuroaugmentation & Specificity (01:17:01) Building a Smart Device, AI (01:20:02) Neural Prosthesis, Paralysis; Specificity (01:25:21) Neurodegeneration; Adult Neuroplasticity; Implant Specificity (01:34:00) Career Journey, Music & Dance, Neuroscience (01:42:55) Self-Understanding, Coffee; Self-Love, Mediation & Yoga (01:47:50) Body Signals & Decisions; Beauty (01:57:49) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer
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