Podcast appearances and mentions of bill jacobs

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Best podcasts about bill jacobs

Latest podcast episodes about bill jacobs

Chicago's Very Own Eats with Kevin Powell and Michael Piff
Piece and Hot Doug's team up to support PAWS Chicago with the ‘Bill and Doug's Excellent Adventure' pizza

Chicago's Very Own Eats with Kevin Powell and Michael Piff

Play Episode Listen Later Jan 9, 2025


Piece Pizzeria & Brewery owner/operator Bill Jacobs returned to the Chicago’s Very Own Eats podcast, and he brought a special guest with him. Bill and Doug Sohn of Hot Doug’s have teamed up to kickoff the annual ‘Slice To Meet You’ campaign, supporting PAWS Chicago. From January 9th to February 8th, you can order their […]

Car Con Carne
Celebrity chef collabs return to Piece Pizzeria for PAWS fundraiser (Episode 1016)

Car Con Carne

Play Episode Listen Later Jan 8, 2025 29:05


Slice to Meet You returns to Piece Pizzeria (1927 North Avenue)! The fundraiser benefiting Paws Chicago, the Midwest’s largest no-kill shelter, kicks off with “Bill and Doug’s Excellent Adventure, a collaboration between Piece and iconic Chicago chef Hot Doug. Piece owner Bill Jacobs and Hot Doug jump in the car to unveil their masterful collab: a white pizza topped with Hot Doug’s Hungarian sausage, thinly sliced Yukon potatoes, roasted garlic, mozzarella, and finished with horseradish cream sauce, grated aged Pecorino Romano, and scallions. For every “Bill and Doug’s” pizza sold, Paws will receive $70, thanks to Piece and generous matching donors. Yeah, the pizza was outstanding, but I really enjoyed talking with Bill and Doug. I think you’ll enjoy the conversation - it’s an episode absolutely dripping with Chicago and food talk. After you’ve scarfed down this month’s pizza, get ready for the next two collaborations in February (the Weiner’s Circle) and March (Rick Bayless). Visit Piece on social media: @piecechicago Visit Paws online: pawschicago.com ## Car Con Carne sponsored by Easy Automation: easy-automation.net Transform your living space with cutting-edge home automation. Experience seamless control over audio/video, lighting, climate, security, and more. Embrace the future of smart living – your home, your rules. Get a quote by visiting easy-automation.net, or give Dan a call at 630.730.3728 See omnystudio.com/listener for privacy information.

Prove All Things
Human Nature and Original Sin

Prove All Things

Play Episode Listen Later Jan 30, 2024 69:46


Bill Jacobs looks at Genesis 3 to see the origins of human nature.

Smart Pizza Marketing Podcast
SPM #471: Bill Jacobs of Piece Pizzeria (Prioritizing Happiness Over Business Expansion)

Smart Pizza Marketing Podcast

Play Episode Listen Later Jun 15, 2023 42:01


On this episode of Smart Pizza Marketing, we're joined by Bruce and guest Bill to talk about the ins and outs of running a successful small business. They delve into the importance of valuing your employees just as much as your products and how creating a positive culture can lead to overall success. They also discuss the benefits of simplifying menus and focusing on a singular goal, as well as the joy of giving back to the community through charitable collaborations. Plus, they share their insights on the ever-changing world of social media marketing and the power of consistency in promoting your business.    For more podcasts episode or marketing help visit https://www.smartpizzamarketing.com   Learn from us:  https://www.smartpizzamarketing.com/mastermind Work with us: https://www.smartpizzamarketing.com/zip   Get our pdf of 65 content ideas for your restaurant https://www.smartpizzamarketing.com/contentideas   Gear Used for this: Cannon g7x: https://amzn.to/2TaMJql Cannon Rebel t6ii:  https://amzn.to/31r2yhg At2020 microphone: https://amzn.to/3jhh1lM Ring Light: https://amzn.to/34eMPUr Scarlett mixer: https://amzn.to/3m1fNNx   Contact Us:  P.O. Box 82  Swampscott MA 01907   Subscribe to the SPM Podcast: Itunes: http://www.smartpizzamarketing.com/Itunes   Subscribe the Local Business Podcast: Itunes: https://podcasts.apple.com/.../the-local.../id1492927865 Follow along on social:  Facebook: https://www.facebook.com/smartpizzamarketing Instagram: https://www.instagram.com/smartpizzamarketing Bruce Irving: https://www.instagram.com/theBruceIrving Twitter: https://twitter.com/Irvingmedia Website: http://www.smartpizzamarketing.com

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Steve Cochran on The Big 89
Slice to meet you! - PAWS Chicago and Piece Pizza are pairing up to help you find your "fur-ever" pal

Steve Cochran on The Big 89

Play Episode Listen Later Jan 13, 2023 10:56


CEO of PAWS Susanna Wickham, Hot Doug's Doug Sohn, and Piece Pizza's Bill Jacobs visit the Steve Cochran Show to promote the upcoming Betty White Challenge for senior pets, what's in store for their January collaboration, and what else is coming to Piece Pizza this winter. See omnystudio.com/listener for privacy information.

Car Con Carne
The award-winning Piece Pizzeria & Brewery (Episode 802)

Car Con Carne

Play Episode Listen Later Dec 13, 2022 33:17


Car Con Carne pulls up to Wicker Park for a long chat with Bill Jacobs, owner of the much-celebrated Piece Pizzeria & Brewery (1927 W. North Avenue).    As we eat Hot Doug's Atomic Sausage pizza (red pizza with pepper jack, caramelized onions and atomic sausage), we talk about: *Piece's quick rise to fame in Chicago *What exactly is “New Haven-style” pizza? *Rock and Roll Hall of Famer Rick Nielsen's partnership in Piece *Innovation and collaboration *Piece's award winning beers   As a bonus, we're joined by author Andy Frye (90 Days in the 90s). Andy jumped in the backseat to enjoy a vegan pizza from Piece and chime in on the conversation. Speaking of 90 Days in the 90s… Looking for a holiday gift or something cool to read on a road trip this season? Try Ninety Days in the 90s: A Rock N Roll Time Travel Story. It's the ultimate novel about the '90s and Chicago's music scene. Join record store owner Darby on her trip back to 1990s Chicago as she jumps on the Grey Line to time travel back to her carefree twenties, soaking up all the pop culture and rock n roll nostalgia you could ever imagine.  Get a signed copy at 90daysinthe90s.com

The Hot Slice
S4E8 Piece Out

The Hot Slice

Play Episode Listen Later Apr 15, 2021 24:46


Bill Jacobs of Piece Pizzeria and Brewery in Chicago sits down with Jeremy White and Josh Keown on this episode of The Hot Slice podcast. As Piece nears its 20th anniversary, Jacobs discusses New Haven-style pizza, live music, beer and the hope of returning to normalcy soon as the effects of the pandemic begin to diminish. --- Send in a voice message: https://anchor.fm/the-hot-slice/message

Lossano and Friends! on Radio Misfits
Lossano and Friends – From Murder Mysteries To Fresh Cream Cheese

Lossano and Friends! on Radio Misfits

Play Episode Listen Later Oct 6, 2020 70:15


Randy Stancik of the Willis Tower talks about how Tony Lossano keeps turning up everywhere, including one night in his bedroom! Bill Jacobs of Piece Pizza tells how once a worker went missing for a few hours, due to a very generous tipper! And comedian Vickie Eisenstein recognizes The Ledge Read more... The post Lossano and Friends – From Murder Mysteries To Fresh Cream Cheese appeared first on Radio Misfits.

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The Indispensables
The power and importance of local journalism with Bill Jacobs

The Indispensables

Play Episode Listen Later Sep 23, 2020 27:33


In this episode, I talked with Bill Jacobs, who is a member of the board of trustees of King's Daughters Medical Center and former owner and publisher of The Daily Leader and the Prentiss Headlight. We talked about the power and importance of journalism.   Mentioned in this episode: ·        https://olemiss.edu/ (Ole Miss, University of Mississippi) ·        https://mississippiencyclopedia.org/entries/mcraes-department-stores/ (McRae's Department Store) ·        https://www.dailyleader.com/ (The Daily Leader) ·        https://www.prentissheadlight.com/ (The Prentiss Headlight) ·        https://www.kingsdaughtershealth.com/ (King's Daughters Medical Center)   ---   You can purchase your copy of The Art of Being Indispensable at Work from: ·        https://www.amazon.com/Art-Being-Indispensable-Work-Overcommitment/dp/1633698491/ (Amazon) ·        https://www.barnesandnoble.com/w/the-art-of-being-indispensable-at-work-bruce-tulgan/1135022362?ean=9781633698499 (Barnes & Noble) ·        https://www.indiebound.org/book/9781633698499 (Indiebound)   For bulk orders, contact us at: mail@rainmakerthinking.com   Follow Bruce on social media: ·        https://twitter.com/BruceTulgan (Twitter) ·        https://www.linkedin.com/in/brucetulganrmt/ (LinkedIn) ·        https://www.facebook.com/bruce.tulganRMT/ (Facebook)   Learn more about RainmakerThinking at our website: https://rainmakerthinking.com/ (rainmakerthinking.com)

Bridge Builder Podcast
Bill Jacobs On Saint Kateri, Integral Ecology, And Our Common Home

Bridge Builder Podcast

Play Episode Listen Later Aug 24, 2020 30:00


In today’s episode we’re talking about stewarding God’s creation and diving into the concept of integral ecology ahead of the upcoming World Day of Care for Creation on September 1st. We are joined by Bill Jacobs, Founder and Executive Director of the Saint Kateri Conservation Center. In his day job, Bill is the co-founder and program manager of the Long Island Invasive Species Management Area. Bill also served as an interim director of the Saint Kateri National Shrine and Historic Site in New York. Bill holds a Master of Science degree in forest resources management. In our mailbag segment we’re covering a question about what parishes can do in order to help Catholics prepare for the election. And stick around for the bricklayer segment we have a guide that you can use to begin to put into action our call to be stewards of all of God’s Creation. Learn more here: https://www.kateri.org/,www.MNCatholic.org/Election, www.MNCatholic.org/OurCommonHome

Pete McMurray and Jane Monzures from WGN Radio 720
Piece Brewery and Pizzeria founder Bill Jacobs on re-opening amid COVID-19

Pete McMurray and Jane Monzures from WGN Radio 720

Play Episode Listen Later Jun 27, 2020


CEO and founder of Piece Brewery and Pizzeria joins Pete McMurray to discuss how his restaurant is handling the process of re-opening and what they hope to see in the future.

3AW is Football
From The 3AW Vault: 1990 AFL Grand Final - Collingwood v Essendon

3AW is Football

Play Episode Listen Later May 29, 2020 138:16


With the 2020 AFL season on hold, 3AW will each weekend podcast some of the greatest matches we've ever broadcast, corresponding with a clash that was meant to be played each round. This week: The drama-filled 1990 Grand Final between fierce rivals Collingwood and Essendon. Your commentators: Rex Hunt and Bill Jacobs. Special comments: Ron Barassi, Sam Newman and John Murphy. Click PLAY below, or catch it on your favourite podcasting app. It's all supported by Wynstan -- check out their blinds, doors, shutters and awnings here.

Pete McMurray and Jane Monzures from WGN Radio 720
Good news for pizza lovers! Piece Pizzeria is opening up!

Pete McMurray and Jane Monzures from WGN Radio 720

Play Episode Listen Later May 3, 2020


After being closed for several weeks due to the Coronavirus. Bill Jacobs, owner of Piece Pizzeria, joins WGN Radio’s Pete McMurray to share the new procedures the restaurant is taking to get your pizza to you and how they are adapting to this new normal.

3AW is Football
From The 3AW Vault: Collingwood v Richmond - 1980 Grand Final

3AW is Football

Play Episode Listen Later Mar 27, 2020 130:17


With the 2020 AFL season on hold, 3AW will podcast some of the greatest matches we've ever broadcasted, corresponding with a clash that was meant to be played each round. Thanks to our supporters, Wynstan -- check out their blinds, doors, shutters and awnings here: https://www.wynstan.com.au/ This week: The 1980 GF classic between Richmond and Collingwood. Your commentators: Harry Beitzel, Bill Jacobs, Tommy Lahiff. Special comments: Rex Hunt, Neil Kerley, Frank Considine, Greg Browne, Gary Brice, "Polly" Perkins and Ray Young on stats.

microTalk
061: TB or not TB? That is the Question… for Bill Jacobs

microTalk

Play Episode Listen Later Dec 2, 2019 48:09


Tuberculosis (TB) remains one of the most prevalent infectious diseases in the world, with approximately 10 million people becoming sick and 1.5 million people dying every year from Mycobacterium tuberculosis infection. Dr. William Jacobs is a Professor at the Albert Einstein College of Medicine and member of the National Academy of Sciences who studies M. tuberculosis. TB is notoriously difficult to treat, due to the slow growth and persistence of the bacteria in the lungs, requiring extensive antibiotic treatment over a long period of time. Dr. Jacobs talks about the history of tuberculosis (“consumption”) in humans, how M. tuberculosis can hang out in the lungs for an entire lifetime, how slow growth is a bacterial strategy to avoid killing by antibiotics, how growth in armadillos is required to study the closely related M. leprae (causes leprosy), just how scary drug-resistant TB strains are, and how dirt from the Bronx Zoo was hiding a genetic tool that was a game-changer for the study of TB. The microCase for listeners to solve is about Ella Copta and Lana Jorgia, two internet vloggers who become ill after visiting an African shaman. Participants: Karl Klose, Ph.D. (UTSA) William Jacobs, Ph.D. (Albert Einstein College of Medicine) Janakiram Seshu, Ph.D. (UTSA) Mylea Echazarreta (UTSA) Abigail Blaschke (UTSA) Jacobi Brown (UTSA)

The 3AW Archive.
S1E111: 3AW - Football call Bill Jacobs, Harry Beitzel. Peter Hudson kicks 8.3.

The 3AW Archive.

Play Episode Listen Later Nov 19, 2019 20:09


25 Aug, 1973.  Hawthorn Football Club's Peter Hudson has returned from Tasmania.  In the first round of last season, he seriously injured his knee.  It was a possible career ending injury.  But it wasn't. Here, as called by Harry Beitzel and Bill Jacobs, Peter kicks eight goals and three behinds against Collingwood at VFL Park Photo: FoxSports See omnystudio.com/listener for privacy information.

The 3AW Archive.
S1E71: 3AW Bill Jacobs calling a punch up during the football. Apr 1989

The 3AW Archive.

Play Episode Listen Later Aug 27, 2019 1:46


A 3AW footy piece with Bill Jacobs of a big footy punch up incident in April 1989. It's great stuff. See omnystudio.com/listener for privacy information.

First Christian Church of Portland Oregon
FCC Podcast: Jul 28, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Jul 29, 2019 25:29


Rev. Mary and Bill Jacobs, Interim Ministers:"Goodbye and Hello"

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First Christian Church of Portland Oregon
FCC Podcast: Jul 14, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Jul 15, 2019 26:37


Rev. Bill Jacobs, Interim Minister:"Beginner’s Mind"

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The 3AW Archive.
S1E18: Ep 018 3AW Rex Hunt with Darren James and Uncle Roy. 02 Feb, 1989

The 3AW Archive.

Play Episode Listen Later Jun 13, 2019 4:12


10 years after joining 3AW as an Around the grounds commentator. Rex Hunt returned to 3AW to take up a senior commentary role alongside Bill Jacobs. Here, Rex Hunt joins Darren and Unca's World of Sport segment.See omnystudio.com/listener for privacy information.

First Christian Church of Portland Oregon
FCC Podcast: Jun 2, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Jun 7, 2019 24:17


Rev. Bill Jacobs, Interim Minister:"Emotional Rescue"

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The 3AW Archive.
S1E1: Ep 001 3AW Darren James and Uncle Roy Aircheck.

The 3AW Archive.

Play Episode Listen Later May 21, 2019 19:51


From 23 Sept, 1986. An aircheck from 3AW's Darren James and Uncle Roy breakfast show.This aircheck includes Malcolm Stewart, Roy's Route, and a little bit of Bill Jacobs.(Photo credit: Ash Long)See omnystudio.com/listener for privacy information.

First Christian Church of Portland Oregon
FCC Podcast: May 5, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later May 6, 2019 24:57


Rev. Bill Jacobs, Interim Minister:"Glory!"

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First Christian Church of Portland Oregon
FCC Podcast: Apr 14, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Apr 15, 2019 21:09


Rev. Bill Jacobs, Interim Minister: "Turn Down the Volume!"

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First Christian Church of Portland Oregon
FCC Podcast: Apr 7, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Apr 8, 2019 24:58


Rev. Bill Jacobs, Interim Minister: "Turning, We Come Round Right"

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First Christian Church of Portland Oregon
FCC Podcast: Mar 24, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Mar 28, 2019 17:56


Rev. Bill Jacobs, Interim Minister:"Second Chance for Growth"

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First Christian Church of Portland Oregon
FCC Podcast: Mar 10, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Mar 11, 2019 26:32


Rev. Bill Jacobs, Interim Minister: "Is This a Good Time for You?"

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First Christian Church of Portland Oregon
FCC Podcast: Mar 3, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Mar 5, 2019 24:17


Rev. Bill Jacobs, Interim Minister: "Afraid of the Light"

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First Christian Church of Portland Oregon
FCC Podcast: Feb 17, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Feb 18, 2019 24:01


Rev. Bill Jacobs, Interim Minister: "Blessed Are the Upside Down"

First Christian Church of Portland Oregon
FCC Podcast: Feb 3, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Feb 4, 2019 23:04


Rev. Bill Jacobs, Interim Minister:“Keeping Score”

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First Christian Church of Portland Oregon
FCC Podcast: Jan 20, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Jan 21, 2019 22:28


Rev. Bill Jacobs, Interim Minister: "Way Down In Egypt’s Land"

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First Christian Church of Portland Oregon
FCC Podcast: Jan 13, 2019

First Christian Church of Portland Oregon

Play Episode Listen Later Jan 14, 2019 20:56


Rev. Bill Jacobs, Interim Minister: "What Shall I  Bring"

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First Christian Church of Portland Oregon
FCC Podcast: Dec 23, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Dec 24, 2018 18:31


Rev. Bill Jacobs, Interim Minister: "Love Lights the Way"

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First Christian Church of Portland Oregon
FCC Podcast: Dec 9, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Dec 9, 2018 25:29


Rev. Bill Jacobs, Interim Minister: "From Silence to Song"

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First Christian Church of Portland Oregon
FCC Podcast: Nov 18, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Nov 19, 2018 24:40


Rev. Bill Jacobs, Interim Minister: "The Caravan is Coming!"

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First Christian Church of Portland Oregon
FCC Podcast: Nov 4, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Nov 5, 2018 28:35


Rev. Bill Jacobs, Interim Minister: "A Time for Everything"

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First Christian Church of Portland Oregon
FCC Podcast: Oct 7, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Oct 9, 2018 22:03


Rev. Bill Jacobs, Interim Minister: "One Bread, One Body"

First Christian Church of Portland Oregon
FCC Podcast: Sept 23, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Sep 29, 2018 22:52


Rev. Bill Jacobs, Interim Minister "Where Does Our Story Begin?"

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First Christian Church of Portland Oregon
FCC Podcast: Sep 9, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Sep 10, 2018 18:56


Rev. Bill Jacobs, Interim Minister: "Author! Author!"

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First Christian Church of Portland Oregon
FCC Podcast: Aug 26, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Aug 27, 2018 24:18


Rev. Bill Jacobs, Interim Minister:"There’s Within My Heart A Melody"

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First Christian Church of Portland Oregon
FCC Podcast: Aug 12, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Aug 13, 2018 23:47


Rev. Bill Jacobs, Interim Minister: "Cast Wide and Deep"

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First Christian Church of Portland Oregon
FCC Podcast: Jul 15, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Jul 15, 2018 18:23


Rev. Bill Jacobs, Interim Minister: "Hidden In Plain Sight"

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First Christian Church of Portland Oregon
FCC Podcast: Jul 1, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Jul 2, 2018 29:54


Rev. Bill Jacobs, Interim Minister: "Seriously, Why Bother?"

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First Christian Church of Portland Oregon
FCC Podcast: Jun 17, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Jun 18, 2018 20:50


Rev. Bill Jacobs, Interim Minister: "A Love That Won’t Quit"

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The Independent Republic of Mike Graham
Salad Cream, Northern Trains and Jamie Oliver

The Independent Republic of Mike Graham

Play Episode Listen Later Jun 6, 2018 29:13


Salad Cream or Sandwich Cream- how do you eat yours? Heinz have proposed a name change due to the function of the condiment but it may in turn have been a great publicity stunt and also brought to attention the snobbery of the mayo brigade.As train chaos has been rife countrywide, local newspapers across the north of England have filed a petition for the government to pay some attention outside of London, and Bill Jacobs from the Lancashire Telegraph fills us in on the transport misery.And finally, Jamie Oliver. What now? You ask. Well, he is seeking to have junk food advertising banned, however Channel 4's bosses have pointed out that without the revenue of some 'junk food brands' adverts, they could lose around £200 million. Steve Miller, director of Fatnosis, has something to say about the whole thing. See acast.com/privacy for privacy and opt-out information.

First Christian Church of Portland Oregon
FCC Podcast: Jun 3, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Jun 4, 2018 18:35


Rev. Bill Jacobs, Interim Minister: "God Always Starts Small"

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First Christian Church of Portland Oregon
FCC Podcast: Apr 22, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Apr 25, 2018 20:52


Rev. Bill Jacobs, Interim Minister: "Creativity Re-Membered"

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First Christian Church of Portland Oregon
FCC Podcast: Apr 15, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Apr 16, 2018 22:44


Rev. Bill Jacobs, Interim Minister: "MLK Jr. Re-Membered"

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First Christian Church of Portland Oregon
FCC Podcast: Apr 8, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Apr 9, 2018 24:28


Rev. Bill Jacobs, Interim Minister: "Thomas Re-Membered"

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First Christian Church of Portland Oregon
FCC Podcast: Apr 1, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Apr 1, 2018 17:02


Rev. Bill Jacobs, Interim Minister:"Ready Player One"

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First Christian Church of Portland Oregon
FCC Podcast: Mar 18, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Mar 19, 2018 20:47


Rev. Bill Jacobs, Interim Minister: "The Broken Cup"

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Meet the Microbiologist
078: Tuberculosis treatment and mycobacterial genetics with Bill Jacobs

Meet the Microbiologist

Play Episode Listen Later Mar 15, 2018 59:37


Bill Jacobs talks about developing mycobacterial genetic tools and using them to discover ways to shorten TB treatment. He also talks about the SEA-PHAGES program that allows high-school students to participate in phage discovery. Host: Julie Wolf Subscribe (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the ASM Podcast app. Julie's biggest takeaways: The challenges of working with an easily aerosolized bacterium are aided by complementary studies on a noninfectious relative. M. smegmatus doesn’t colonize mammals and grows slower, giving researchers the opportunity to acclimate themselves to working with mycobacterial cultures. Jacobs was the first scientist to introduce DNA into M. tuberculosis using a phasmid - part plasmid, part mycobacterial phage. The first phage came from Jacobs’ dirt yard in the Bronx, so he named it BxB1 for the Bronx Bomber. Another phage, TM4, became the workhorse phasmid when Jacobs cloned an E. coli cosmid sequence into a nonessential part of the phage genome. It replicates in E. coli as a plasmid but becomes a phage inside Mycobacteria, facilitating manipulation. The shuttle phasmids allowed transposon delivery to make transposon libraries, and the creation of gene knockouts. To this day, we use Ziehl-Neelsen staining to differentiate acid-fast mycobacteria from gram-positive or gram-negative bacteria - the mycolic acids on the outer part of the envelope make up some of the longest microbial lipid chains. But mycobacteria can regulate its acid-fast positive or negative status; the acid-fast negative organisms are a persistent population that are often ignored inside of patients. 99.99% of M. tuberculosis bacteria are not persistent, but the last 0.1% have entered into a persistent state expressing many stress proteins that help them become refractory to killing. A normal course of antibiotic chemotherapy for patients is six months. If infected with a strain resistant to the two frontline drugs, that time goes up to two years. The problem is even greater in extremely multidrug resistant (XDR) strains. What we really need is a way to understand persistence and a way to shorten chemotherapy. That’s why were were absolutely amazed when we discovered that cysteine with isoniazid completely sterilizes Mtb cultures in vitro and in vivo! The culture is sterilized because the bacteria can’t form persisters. Vitamin C co-treatment with antibiotics may lead to a shortened course of therapy for TB treatment. Neutralizing antibodies to the herpesvirus glycoprotein have been the dogma for protecting from herpes. Jacobs and his colleagues discovered that a vaccine based on a glycoprotein-knockout virus confers sterilizing immunity not through neutralizing antibodies but through antibody-dependent cell cytoxicity (ADCC). This ADCC response may also be important to develop a more effective TB vaccine.   Featured Quotes (in order of appearance): “You’ll never know how bad your aseptic technique is until you start working with tuberculosis!” “I think part of the reason I had the opportunity to develop genetics for TB - it’s not like it wasn’t important to do - but a lot of people were disappointed when working with the organism.” “We’re about to take TB genetics to where yeast genetics is.” “One of the tubicle bacilli’s greatest powers or one of its most important phenotypes is that it has the ability to persist, which means it has the ability to tolerate killing effectors, either killing by the immune system or killing by bactericidal drugs.” “I took students to the Bronx Zoo, and over by the zebra pen, I sniffed and said ‘I smell a phage!’ In fact, that’s not crazy - anyone who plants flowers knows what good soil smells like, and in the good soil, you’re smelling the bacteria that live in the soil, the Streptomyces and Mycobacteria. I reached down and grabbed that dirt, and when we went back to work we isolated BxE1.” “I’ve never met a phage I wasn’t excited about!” “I now believe that most pathogens do not ‘want’ ADCC antibodies to be made, and they have immune evasion strategies where they skew the immune response to get the wrong antibodies. Since the time we published our first paper, numerous groups have shown that correlates of protection for HIV, for influenza, and for Zika, turn out to be ADCC antibodies.” “Genetics is the mathematics of biology!”   Links for this episode Bill Jacobs lab site NYTimes story on 1993 rapid diagnostic test using luciferase AACJournal: Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in mice Cell: Origins of highly mosaic mycobacteriophage genomes SEA-PHAGES program eLife: Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity mBio: Dual-reported mycobacteriophages (Φ2DRMs) reveal preexisting Mycobacterium tuberculosis persistent cells in human sputum Tuberculosis - Its cause, cure and prevention [1914] (pdf)   Send your stories about our guests and/or your comments to jwolf@asmusa.org.  

First Christian Church of Portland Oregon
FCC Podcast: Mar 11, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Mar 12, 2018 19:43


Rev. Bill Jacobs, Interim Minister:"In This Very Room"

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First Christian Church of Portland Oregon
FCC Podcast: Feb 25, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Feb 25, 2018 23:12


Rev. Bill Jacobs, Interim Minister: "The Cup of Compassion"

First Christian Church of Portland Oregon
FCC Podcast: Feb 11, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Feb 11, 2018 17:07


Rev. Bill Jacobs, Interim Minister:"Radiant"

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First Christian Church of Portland Oregon
FCC Podcast: Jan 21, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Jan 22, 2018 23:40


Rev. Bill Jacobs, Interim Minister:"Cast of Characters"

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First Christian Church of Portland Oregon
FCC Podcast: Jan 14, 2018

First Christian Church of Portland Oregon

Play Episode Listen Later Jan 15, 2018 21:19


Rev. Bill Jacobs, Interim Minister "Can Anything Good Come From Alabama?"

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First Christian Church of Portland Oregon
FCC Podcast: Dec 31, 2017

First Christian Church of Portland Oregon

Play Episode Listen Later Jan 1, 2018 14:25


Rev. Bill Jacobs, Interim Minister:"Release and Receive"

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First Christian Church of Portland Oregon
FCC Podcast: Dec 24, 2017

First Christian Church of Portland Oregon

Play Episode Listen Later Dec 25, 2017 12:56


Rev. Bill Jacobs, Interim Minister: "Messy Christmas, Everyone"

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First Christian Church of Portland Oregon
FCC Podcast: Dec 3, 2017

First Christian Church of Portland Oregon

Play Episode Listen Later Dec 4, 2017 17:57


Rev. Bill Jacobs, Interim Minister: "Night Light"

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First Christian Church of Portland Oregon
FCC Podcast: Nov 12, 2017

First Christian Church of Portland Oregon

Play Episode Listen Later Nov 13, 2017 21:20


Rev. Bill Jacobs, Interim Minister: "Melt Me, Mold Me"

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First Christian Church of Portland Oregon
FCC Podcast: Oct 22, 2017

First Christian Church of Portland Oregon

Play Episode Listen Later Oct 23, 2017 23:13


Rev. Bill Jacobs, Interim Minister: "Team Moses"

rev podcast oct bill jacobs
First Christian Church of Portland Oregon
FCC Podcast: Oct 15, 2017

First Christian Church of Portland Oregon

Play Episode Listen Later Oct 17, 2017 22:10


Rev. Bill Jacobs, Interim Minister: "My Brother Needs Me"

rev podcast oct bill jacobs
Smart Pizza Marketing Podcast
SPM #157: Bill Jacobs Piece Pizza Chicago

Smart Pizza Marketing Podcast

Play Episode Listen Later Oct 5, 2017 31:30


Piece Pizza is one of the busiest single unit locations in the country. Bill joins me to chat business and strategy on how they achieved this. Mentioned In This Episode Smart Pizza Marketing Mastermind Smart Pizza Marketing Email (the best email) SPM Marketing Platform Thanks For Listening Thank you for taking the time to listen to this episode. I hope that you have found it to be valuable. If you have a question or comment you can email at Bruce@smartpizzamarketing.com  Like us on Facebook too for updates and interesting marketing articles Leave us a quick Review  If you did find this information valuable it would be awesome if you could share it using the social media buttons on the side of the post. Also, please leave a quick review on Itunes or Stitcher… would really help

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First Christian Church of Portland Oregon
FCC Podcast: Oct 1, 2017

First Christian Church of Portland Oregon

Play Episode Listen Later Oct 2, 2017 19:45


Rev. Bill Jacobs, Interim Minister: "Manna Overboard"

rev podcast oct bill jacobs
First Christian Church of Portland Oregon
FCC Podcast: Sep 17, 2017

First Christian Church of Portland Oregon

Play Episode Listen Later Sep 17, 2017 24:41


Rev. Bill Jacobs, Interim Co-Minister: "Head For the Hills"

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Lossano and Friends! on Radio Misfits
Lossano and Friends! – 03/13/16

Lossano and Friends! on Radio Misfits

Play Episode Listen Later Mar 13, 2016 71:45


Ep60 - Randy Stancik of the Willis Tower talks about how Tony Lossano keeps turning up everywhere, including one night in his bedroom! Bill Jacobs of Piece Pizza tells how once a worker went missing for a few hours, due to a very generous tipper! And comedian Vickie Eisenstein recognizes The Ledge at the Willis Tower as the place where everyone takes their Tinder profile pic! That and so much MORE! The post Lossano and Friends! – 03/13/16 appeared first on Radio Misfits.

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Sounds of the SEA
Bill Jacobs

Sounds of the SEA

Play Episode Listen Later Nov 6, 2015 36:04


We talk to Mycobacterial legend Bill Jacobs, the creator of shuttle phasmids, the developer of the beloved smeg strain mc²155, and the twin brother of our very own Debbie Jacobs-Sera. Bill talks about how he got into science, his past Mycobacterial work, a potential vaccine for Herpes, and armadillos.

Sounds of the SEA
Bill Jacobs

Sounds of the SEA

Play Episode Listen Later Nov 6, 2015 36:04


We talk to Mycobacterial legend Bill Jacobs, the creator of shuttle phasmids, the developer of the beloved smeg strain mc²155, and the twin brother of our very own Debbie Jacobs-Sera. Bill talks about how he got into science, his past Mycobacterial work, a potential vaccine for Herpes, and armadillos.

Science Talk
Science Talk: Study Finds Vitamin C Can Kill Drug-Resistant TB

Science Talk

Play Episode Listen Later May 21, 2013 3:26


May 21, 2013 - Dr. William Jacobs, Jr., has determined that vitamin C kills drug-resistant tuberculosis bacteria in laboratory culture. The paper was published online May 21, in Nature Communications. Dr. Jacobs is professor of microbiology & immunology and of genetics at Einstein. Dr. Jacobs is also a Howard Hughes Medical Institute investigator. See accompanying release: http://www.einstein.yu.edu/news/releases/907/study-finds-vitamin-c-can-kill-drug-resistant-tb/

Fundraising is Beautiful
The two big trends in fundraising today

Fundraising is Beautiful

Play Episode Listen Later Jan 25, 2011 24:11


For the second installment of our new State of Fundraising series of podcasts, we interview Bill Jacobs of Grizzard, whom you can frequently read at Grizzard's Blog. Bill talks about two massive changes that are hitting the fundraising industry: The arrival of Boomers in their prime giving years and the way donors now respond to our fundraising as they please -- not necessarily in the ways we want them to. (Up to a third of response to direct mail comes in through channels other than mail!) If we don't respond to these huge and growing trends, we are in deep trouble in the coming years.

Realcomm 2007
Bill Jacobs of Cisco

Realcomm 2007

Play Episode Listen Later Jun 5, 2007


A technology/convergence success story that was much discussed, implemented ten years ago and is now online. Bill Jacobs discuss their program to IP enable all digital, video and access controls across the networks to globally manage 440 locations and 17.5 million SF. Through centralized operation centers, the company saves $10 million/year on a recurring revenue basis. This has implemented greater business continuity and security applications. A peek at the future is also discussed.

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