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Neural connections rapidly develop in early childhood, but the brain continues to grow and refine these connections throughout our lives, even into older adulthood. That's why enriching experiences — such as traveling, socializing, education, and exercise — are particularly impactful for the brain and need to keep happening throughout our lives. Staying engaged is the topic of discussion this week on Dr. Greg Davis on Medicine. Elizabeth Rhodus, Ph.D., is an occupational therapist and assistant professor in UK's Sanders-Brown Center on Aging.
LEXINGTON, Ky. (May 8, 2025) – THIS IS AN ENCORE PRESENTATION. The University of Kentucky Alzheimer's Disease Research Center at the Sanders-Brown Center on Aging is celebrating 40 years of research and community impact. The center is world-renowned for its significant contributions to the field through the decades. As the UK-ADRC celebrates this milestone, we reflect on how the Center has evolved over the years and highlight some of its notable achievements. This episode of Behind the Blue features a conversation with Dr. Linda Van Eldik, Director of the Sanders-Brown Center on Aging and Alzheimer's Disease Center. Van Eldik highlights the 40-year journey of the Center, focusing on its origins, community engagement, and the evolution of Alzheimer's research. The discussion covers the importance of understanding dementia through biomarkers, the significance of translational research, and the center's commitment to preventative strategies and lifestyle interventions. She emphasizes the need for community outreach, education, and the role of philanthropy in advancing research efforts. Behind the Blue is available via a variety of podcast providers, including iTunes and Spotify. Become a subscriber to receive new episodes of “Behind the Blue” each week. UK's latest medical breakthroughs, research, artists and writers will be featured, along with the most important news impacting the university. Behind the Blue is a joint production of the University of Kentucky and UK HealthCare. Transcripts for this or other episodes of Behind the Blue can be downloaded from the show's blog page. To discover how the University of Kentucky is advancing our Commonwealth, click here.
Researchers at the University of Kentucky are part of a groundbreaking clinical trial exploring the use of medical marijuana in managing symptoms of late-stage dementia. Greg Jicha, M.D., Ph.D., a neurologist and director of clinical trials at UK's Sanders-Brown Center on Aging,talks with Dr. Greg about the National Institutes of Health-funded and Food and Drug Administration-approved LiBBY Study examining the potential benefits of cannabis-derived treatments for addressing agitation and discomfort in patients with advanced dementia, a population with limited palliative care options.
LEXINGTON, Ky. (January 29, 2025) – The University of Kentucky Alzheimer's Disease Research Center at the Sanders-Brown Center on Aging is celebrating 40 years of research and community impact. The center is world-renowned for its significant contributions to the field through the decades. As the UK-ADRC celebrates this milestone, we reflect on how the Center has evolved over the years and highlight some of its notable achievements. This episode of Behind the Blue features a conversation with Dr. Linda Van Eldik, Director of the Sanders-Brown Center on Aging and Alzheimer's Disease Center. Van Eldik highlights the 40-year journey of the Center, focusing on its origins, community engagement, and the evolution of Alzheimer's research. The discussion covers the importance of understanding dementia through biomarkers, the significance of translational research, and the center's commitment to preventative strategies and lifestyle interventions. She emphasizes the need for community outreach, education, and the role of philanthropy in advancing research efforts. Behind the Blue is available via a variety of podcast providers, including iTunes and Spotify. Become a subscriber to receive new episodes of “Behind the Blue” each week. UK's latest medical breakthroughs, research, artists and writers will be featured, along with the most important news impacting the university. Behind the Blue is a joint production of the University of Kentucky and UK HealthCare. Transcripts for this or other episodes of Behind the Blue can be downloaded from the show's blog page. To discover what's wildly possible at the University of Kentucky, click here.
In the ever-evolving field of Alzheimer's disease research, the development of disease-modifying therapies has sparked both excitement and debate. Two new publications from University of Kentucky researchers highlight critical advancements and their intersection with other fields that are considered more successful in advances to date. The collaborative papers were led by Greg Jicha, M.D., Ph.D., and Pete Nelson, M.D., Ph.D., both with UK's Sanders-Brown Center on Aging. The work showcases the profound impact of partnerships across UK — in this case between the Alzheimer's Disease Research Center and the UK Markey Cancer Center. Dr. Greg talks with Nelson about this team approach to tackling this vexing disease.
We humans share over 99% of our DNA with each other. This means personalised therapies for diseases such as cancer or neurodegenerative conditions have to be tailored to the most minute differences between us - or even between our own cells. Professor Mark Ebbert of the Sanders-Brown Center on Aging at the University of Kentucky leads a lab focusing on isoforms of RNA - tiny, short lived molecules - that could open whole new avenues for detection, diagnosis, and treatments of otherwise incurable diseases.Read the original research: https://doi.org/10.1101/2023.08.06.552162 Find more at The Ebbert Lab
DG had the pleasure of speaking with April Stauffer from the Sanders Brown Center on Aging. They covered a wide array of topics related to brain health, aging, and groundbreaking research endeavors. Here are three key takeaways from the insightful conversation:
Healthy brain aging is a concern for all of us. It's normal to struggle with small things such as recalling names — and we all experience some slowing of the thought processes with advanced age — but everyone hopes to avoid serious cognitive impairment. Dr. Greg Jicha with the Sanders - Brown Center on Aging shares tips with Dr. Greg on how to maintain good brain health.
This week on Dr. Greg Davis on Medicine Dr. Pete Nelson with UK's Sanders Brown Center on Aging talks about this rare form of dementia
Jack talks to April Stauffer & Dr. Greg Jicha from the Sanders Brown Center on Aging about an event they are holding to raise awareness for Alzheimer's and Dementia. See omnystudio.com/listener for privacy information.
Host: Mindy McCulley, Extension Specialist for Instructional Support, Family and Consumer Sciences Extension, University of Kentucky Guests: Elizabeth Rhodus, PhD Sanders Brown Center on Aging and Amy Kostelic, PhD Assistant Extension Professor for Adult Development and Aging Season 6, Episode 41 This episode starts with a profound conversation around brain health, emphasizing the importance of hydration, engagement, rest and the roles they play in brain performance. We explore disease and the implications of various brain functionality disorders. Learn about the critical concept of cognitive reserve and the value of life-enhancing experiences in constructing a dense neural network, serving as a potential defense against cognitive diseases. Our experts touch base on the importance of social engagement, sensation, and physical activities, shaping a holistic approach towards brain health. For more information, click the links below: Sanders Brown Center on Aging Are you caring for someone with dementia? Harmony at H.O.M.E. (Help Online Modifying the Environment) Telehealth Program Connect with FCS Extension through any of the links below for more information about any of the topics discussed on Talking FACS. Kentucky Extension Offices UK FCS Extension Website Facebook Instagram FCS Learning Channel
The annual American Society for Neurochemistry conference is a unique meeting that brings young and seasoned scientists together to experience cutting-edge neurochemistry and neurobiology. This year the conference will be held at the University of Kentucky from March 18-22 and we have a preview. Dr. Greg talks with Linda Van Eldik, director of UK's Sanders-Brown Center on Aging. She's also the chair of the public forum which is scheduled for 4 to 6 p.m. on March 18th at the Hyatt Regency Hotel in downtown Lexington. The forum will look at topics ranging from healthy brain aging to addressing risks and disparities in the community.
The University of Kentucky is a site for the groundbreaking AHEAD study, the first-ever clinical trial to test the effect of a promising drug known as lecanemab. Just a few weeks ago the U.S. Food and Drug Administration approved Leqembi (lecanemab-irmb) via the Accelerated Approval pathway for the treatment of Alzheimer's disease. This represents an important advancement in the ongoing fight to effectively treat Alzheimer's disease, and UK's Sanders-Brown Center on Aging is on the forefront of the work. Dr. Greg speaks with Greg Jicha, director of clinical trials at UK's Sanders-Brown Center on Aging.
The Sanders-Brown Center on Aging's annual Markesbery Symposium is this Saturday November 19th at Central Bank Center in Lexington. Dr. Greg gets a preview from Dr. Pete Nelson, Professor of Pathology and Laboratory Medicine. The symposium is free and open to the public.
Learn more from an interview with Steve McCrocklin featured in the summer edition of Today's Transitions magazine with the focus on Intentions. Diagnosed with dyslexia as a child Stephen, and Claudia who is his wife and business partner, co-founded Langsford Learning Acceleration Centers. More information available at weteachreading.com. Elizabeth Rhodus, Ph.D., discusses the pilot program "Healthy Brain Aging Across the Bluegrass" which she is leading as part of the mission of UK's Sanders-Brown Center on Aging & Alzheimer's. For more information, please email elizabeth.rhodus@uky.edu or call 859.257.5562.
LEXINGTON, Ky. (May 18, 2022) – The University of Kentucky is proud to be the home of global leaders in aging and brain research, all striving towards the same goal: finding a stop to the 6th leading cause of death in the United States: Alzheimer's Disease. UK's Sanders-Brown Center on Aging has been around for nearly half a century, helping lead the way in Alzheimer's and dementia research. Center Director Dr. Linda Van Eldik firmly believes they will find a cure through the work going on right here on the UK campus. With their dedicated work recently earning the center renewed funding from the National Institute on Aging, education and community support are big parts of the role Sanders-Brown plays. In between various trainings, workshops and community events, they are also making life-changing and life-saving discoveries. Soon, Van Eldik and others at Sanders-Brown will be able to welcome a very valuable piece to their research – the volunteers – into a brand new facility at UK HealthCare's Turfland Campus. On this episode of Behind the Blue, Van Eldik joins UKPR's Hillary Smith to discuss the larger game plan of finding a cure, and the team effort between those volunteers, the world-class faculty and staff at Sanders-Brown, and the University of Kentucky as a whole. "Behind the Blue" is available on iTunes, Google Play, Stitcher and Spotify. Become a subscriber to receive new episodes of “Behind the Blue” each week. UK's latest medical breakthroughs, research, artists and writers will be featured, along with the most important news impacting the university. For questions or comments about this or any other episode of "Behind the Blue," email BehindTheBlue@uky.edu or tweet your question with #BehindTheBlue. Transcripts for this or other episodes of Behind the Blue can be downloaded from the show's blog page. To discover what's wildly possible at the University of Kentucky, click here.
We’re continuing to listen in on the 2021 Emerging Artist Residents! In this episode Angelic Goldsky and Hayla Ragland talk through their intermedia practices and the ways that their backgrounds, the site of Fort Worden, and time for focus has affected their work. Listen to a special track from Angelic and gain a deep insight into the future archives that both Hayla and Angelic are creating. This conversation is generous, worth listening to in its entirety, and full of various ways to think about transformation and from what art emerges and where it can take us. Angelic GoldskyAngelic Goldsky [t(he)y] is Russian-Jewish trans-gender, queer poetry-excavator and performer. They have been honored to transmute words across Turtle Island and Europe, unearthing what was once buried in silencing language. Goldsky likes to rip apart and release definitions of queerness, transness, spirituality, refuge, migration and exile. They do this through clownery, spoken word music, and performance sorcery, leading them international stages with rabbis, queer clowns, trans politicians, the United Nations, TEDx and the Vogue Theatre. They have been published in Frontier Poetry and SAD Mag among other journals, as well as work on the editorial board of the Room Magazine. They have performed embodiment work exploring radical presence at the Belkin Art Gallery’s Spill: Response and the Or Gallery’s Resurgence exhibition. Goldsky has developed programs in partnership with The Museum of Anthropology, Jewish Queer Trans Vancouver and Everybody Is In Downtown Eastside, working in community cohesion through art and media. They love creating arts space where everyone can be celebrated and honored in full spectrum. They are currently the Poet in Residence at Roundhouse Community Arts Centre, leading various community arts engagement programs for youth and the LGBTQQ2SIA+ community. Angelic has been known to hate taxidermies and love timelessness. Hayla RaglandHayla Ragland is a Seattle-based intermedia artist. They received a BFA in Studio Art and a BA in Psychology from University of Kentucky, where they were a John R. Gaines Fellow for the Humanities. The artist’s practice is responsive to their work in social and cognitive psychology, including work at the Markey Cancer Center, the Sanders-Brown Center on Aging and as a caregiver. Ragland’s artwork maintains concerns for cognition, behavior, and health, and their interventionary roles in social constructs and racialized histories. Using textile, sculpture, and photography, they constructs motifs of the unsound body, investigating the seat of the grotesque in contemporary visual culture, with respect to race, gender, ability, and mediated conceptions of worth. Ragland has completed residencies at Vermont Studio Center, Artscape Gibraltar in Toronto Canada, and is the May 2021 resident at Oxbow, Seattle. They are the recipient of a Chinese travel grant from the Confucius Institute and a Names Fellow Award from the Photographic Center Northwest. Their most recent solo show, entitled /Sections, was on view at Shift Gallery, in Seattle, Washington in January of 2021.
The program is set and registration is open for the 11th annual Sanders-Brown Markesbery Symposium on Aging and Dementia. The event is named in honor and memory of the late William R. Markesbery, M.D., founding director of the Sanders-Brown Center on Aging and Alzheimer's Disease Research Center. Markesbery's legacy of groundbreaking research formed the bedrock for the center's quest to understand and treat Alzheimer's disease and to improve the quality of life of older adults. This week on Dr. Greg Davis on Medicine we preview the virtual event with clinical core director Greg Jicha.
LEXINGTON, Ky. (November 4, 2021) – The University of Kentucky is proud to be the home of global leaders in aging and brain research, all striving towards the same goal: finding a stop to the 6th leading cause of death in the United States: Alzheimer's Disease. UK's Sanders-Brown Center on Aging has been around for nearly half a century, helping lead the way in Alzheimer's and dementia research. Center Director Dr. Linda Van Eldik firmly believes they will find a cure through the work going on right here on the UK campus. With their dedicated work recently earning the center renewed funding from the National Institute on Aging, education and community support are big parts of the role Sanders-Brown plays. In between various trainings, workshops and community events, they are also making life-changing and life-saving discoveries. Soon, Van Eldik and others at Sanders-Brown will be able to welcome a very valuable piece to their research – the volunteers – into a brand new facility at UK HealthCare's Turfland Campus. On this episode of Behind the Blue, Van Eldik joins UKPR's Hillary Smith to discuss the larger game plan of finding a cure, and the team effort between those volunteers, the world-class faculty and staff at Sanders-Brown, and the University of Kentucky as a whole. "Behind the Blue" is available on iTunes, Google Play, Stitcher and Spotify. Become a subscriber to receive new episodes of “Behind the Blue” each week. UK's latest medical breakthroughs, research, artists and writers will be featured, along with the most important news impacting the university. For questions or comments about this or any other episode of "Behind the Blue," email BehindTheBlue@uky.edu or tweet your question with #BehindTheBlue. Transcripts for this or other episodes of Behind the Blue can be downloaded from the show's blog page. To discover what's wildly possible at the University of Kentucky, click here.
LEXINGTON, Ky. (Nov. 19, 2020) – The statistics on Alzheimer’s and dementia inducing brain disease are frightening to look at, and unlike research into cancer and heart disease, researchers have often been frustrated in their efforts to make progress in understanding these diseases. Dr. Peter Nelson, of the University of Kentucky’s Sanders-Brown Center on Aging, has spent the last 15 years in the Commonwealth helping to lead the fight against Alzheimer’s and dementia inducing brain disease. “Clinical trials are where we’re going to make the difference in Alzheimer’s disease and dementia research,” says Nelson. “My colleagues who do the clinical trials do the most clinical trials of anybody in the country. More than Harvard, more than Stanford, more than U. Chicago, the very best in the world. So, if people want to be involved in clinical trial research, this is the place they go.” On this episode of Behind the Blue, UKPR’s Carl Nathe talks with Nelson about the work of the Sanders-Brown Center on Aging, the strategies involved in working with such a complex set of diseases, the personal experience that drives his efforts in this research, and more. "Behind the Blue" is available on iTunes, Google Play, Stitcher and Spotify. Become a subscriber to receive new episodes of “Behind the Blue” each week. UK’s latest medical breakthroughs, research, artists and writers will be featured, along with the most important news impacting the university. For questions or comments about this or any other episode of "Behind the Blue," email BehindTheBlue@uky.edu or tweet your question with #BehindTheBlue. To discover what’s wildly possible at the University of Kentucky, click here.
The 10th annual Sanders Brown Center on Aging's Markesbery Symposium is a virtual event. Dr. Greg gets a preview on the major programming from Dr. Donna Wilcock, Assistant Dean For Biomedicine and Sweeney-Nelms Professor in Alzheimer's Research.
In this episode, we interview Dr. Donna Wilcock, about her cutting-edge research on the role of inflammation, vascular impairment, and cerebrovascular disease on Alzheimer's disease! Dr. Donna Wilcock is a Professor of Physiology at the University of Kentucky and the Sanders-Brown Center on Aging.
Inflammation is a common response throughout the body that fights injury and infection and works to rebuild cells after damage. Inflammation works the same way in the brain, but sometimes the inflammatory response meets damage it can’t manage and becomes dysregulated. Our guest Dr. Linda Van Eldik discusses her research into the connections between neuroinflammation and neurodegenerative diseases like dementia, and how this research can help inform the medical community about drug-based treatments for Alzheimer’s disease. Guest: Dr. Linda Van Eldik, Director, Sanders-Brown Center on Aging
LEXINGTON, Ky. (July 3, 2019) – Alzheimer's disease wreaks emotional havoc on patients, who are robbed of their memories, their dignity, and their lives. It’s financially devastating as well: care for Alzheimer's patients is predicted to top $1 trillion by about the time children born today are having children of their own. More than 70,000 Kentuckians are living with Alzheimer's disease, which likely means that you know someone whose life has been touched -- directly or indirectly -- by dementia. And since that number is expected to rise to more than 85,000 in the next five years or so, Alzheimer's will likely hit closer to home for many of us. But the Sanders-Brown Center on Aging is doggedly pursuing answers to unlock the "how" and "why" dementia occurs with the goal of a treatment by 2050. They are world leaders in dementia research, and research funding for Sanders-Brown has almost tripled in the past 5 years. In this episode of "Behind the Blue," Sanders-Brown director Linda Van Eldik talks about Sanders-Brown's involvement in some of the most important discoveries in the history of Alzheimer's research and what they are doing now to advance the science. Become a subscriber to receive new episodes of “Behind the Blue” each week. UK’s latest medical breakthroughs, research, artists and writers will be featured, along with the most important news impacting the university. For questions or comments about this or any other episode of “Behind the Blue,” email BehindTheBlue@uky.edu or tweet your question with #BehindTheBlue.
LEXINGTON, Ky. (Nov. 19, 2018) – The holidays offer the opportunity to reunite with seldom-seen relatives. Family gatherings often bring people together over traditional foods, activities, and recollections of the past. If you notice memory changes in your older family members, how do you know whether what you're seeing is just part of getting older or something more serious? According to Kelly Parsons of the Sanders-Brown Center on Aging at the University of Kentucky, there's a fine line between normal brain aging and dementia. On this week’s episode of “Behind the Blue”, Parsons joins us to provide tips on warning signs and what to do when you worry that grandma or grandpa might have Alzheimer's, plus advice on making the holidays less stressful for everyone when someone with Alzheimer's is on the guest list. Become a subscriber to receive new episodes of “Behind the Blue” each week. UK’s latest medical breakthroughs, research, artists and writers will be featured, along with the most important news impacting the university. For questions or comments about this or any other episode of “Behind the Blue, “ email BehindTheBlue@uky.edu (mail to: BehindTheBlue@uky.edu) or tweet your question with #BehindTheBlue.
LISTEN TO THE FULL PROGRAM By segment: One Cornell University psychologist Tom Gilovich is coming to EKU to speak about "Happiness in Troubled Times." Listen to a preview conversation about the things that get in the way along the road to joy and contentedness. LISTEN Two There are promising developments in the quest to prevent Alzheimer's. We talk with a leader in the field, Dr. Sanjay Asthana, a keynote speaker at the forthcoming Markesbery Symposium on Aging and Dementia. And, we hear from Dr. Gregory Jicha of UK's Sanders-Brown Center on Aging about exciting research into a selenium compound underway in partnership with the Lexington-based bio-tech company, Alltech. LISTEN Three This month's installment of our "Humans of Central Appalachia" series focuses on "Hillbilly" - a term some wear with pride while others loathe. It's a prelude to a conversation with Ashley York, a Pike County native and now an LA-based filmmaker appearing soon at EKU to screen her documentary film, "Hillbilly," co-directed by Sally Rubin. LISTEN
Renee speaks with aging and caregiving expert Amy Goyer, author of Juggling Life, Work and Caregiving, and Kelly Parsons, CSW, from the University of Kentucky's Sanders-Brown Center about trends in elder care. They discuss the need for elder care in the U.S. and how people can learn best practices to care for their loved ones.
From ONE: The Alltech Ideas Conference 2017, Renee speaks with Dr. Gregory Jicha, a professor in the Department of Neurology and the Sanders-Brown Center on Aging at the University of Kentucky (UK). They discuss the partnership the UK Sanders-Brown Center on Aging has with Alltech in Alzheimer's research.
From ONE: The Alltech Ideas Conference 2017, Renee speaks with Dr. Gregory Jicha, a professor in the Department of Neurology and the Sanders-Brown Center on Aging at the University of Kentucky (UK). They discuss the partnership the UK Sanders-Brown Center on Aging has with Alltech in Alzheimer's research.
Debra Lappin was the guest host for our March Alzheimer’s Talks. She spoke with Dr. Gregory Jicha, Professor of Neurology and the holder of the Robert T. and Nyles Y. McCowan Endowed Chair in Alzheimer’s Disease at the Sanders-Brown Center on Aging at the University of Kentucky Alzheimer’s Disease Center. Dr. Jicha talked about the impact of genetics on Alzheimer’s risk, how genetic research is affecting the development of medicines, and why individuals with risk genes are important for clinical trials. Support the show (https://www.usagainstalzheimers.org/ways-donate)
Intermittent fasting—alternating days in which you fast or eat only a few hundred calories a day—may have significant long-term health benefits, according to some researchers. Mark Mattson is a leading expert on intermittent fasting, and one of its proponents on a personal level as well. As a neurosciences professor at Johns Hopkins University, and chief of the laboratory of neurosciences at the National Institute on Aging (NIA), Mattson is particularly interested in how fasting can improve cognitive function and reduce the risk of neurodegenerative diseases. Intermittent fasting might play a role in preventing or postponing neurodegenerative disorders such as Alzheimer’s, which fifty percent of Americans living into their eighties are predicted to get. In this episode, Mattson talks with IHMC Director Ken Ford and IHMC visiting research scientist Dominic D’Agostino about the benefits of fasting and the physiological mechanisms behind those benefits. Mattson is a prolific scientific researcher, and you can find links to some of his work at Mattson ARR 2015 ; Mattson Cell Metabolism 2012 ; and Mattson Sci Amer 2015. Mattson recently delivered an excellent lecture at IHMC on intermittent fasting and optimizing cognitive performance: http://tinyurl.com/zc2xxhc. You can also find his TED talk at http://tinyurl.com/nt24z5p. For more information on Mattson’s career and research, check out his Wikipedia page: http://tinyurl.com/gmpd3we 1:30: Ford says, “Intermittent fasting has become very popular and Mark Mattson is, in our view, the premier authority on this matter.” 2:30: Ford reads iTunes five-star review from “Carl”: “Really smart, really interesting people being interviewed by the same. IHMC is a fascinating place, and attracts like-minded people.” 3:57: Mattson’s interest in science began in ninth grade, when he wrote an essay on cryopreservation. 4:29: He got interested in aging during his Ph.D., while studying developmental neurobiology and cell death. 6:37: Mattson spent eleven years at the University of Kentucky at the Sanders Brown Center on Aging. 7:20: Mattson explains the basic rationale behind intermittent fasting: If you challenge yourself/cells bio-energetically through exercise or fasting, nerve cells respond adaptively—and pathways are activated that increase neuronal resistance to stress and age-related neurodegenerative disorders. 8:10: Mattson conducted studies in which he subjected animals to alternative day fasting, with a 10-25 percent calorie-restricted diet on the days in which they ate. “If you repeat that when animals are young, they live 30 percent longer.” The animals’ nerve cells were more resistant to degeneration. 10:10: Mattson explains the “5:2” study: There were one hundred women in two groups: one group ate 25 percent fewer calories daily; the other group ate only 500 calories/day for two days. 10:57: The take-home message: “Women on the 5:2 diet lost more body fat, retained more lean muscle mass, and had an improvement in glucose regulation. This is consistent with what we know about fasting in terms of general energy metabolism.” 12:08: Fasting for 12 or more hours causes fatty acids to go into the blood stream/liver and are converted into ketones, which are a good alternative energy source for cells. 13:00: Mattson describes how fasting may benefit the brain. 14:20: Mattson talks about three types of fasting regimens: the 5:2 diet; alternate day fasting (500-600 calories on “fasting” days); and time-restricted feeding, where you limit time window that you take in calories to six to eight hours. 16:58: Mattson explains the following dietary “myths”: breakfast is the most important meal of the day; it’s necessary to eat three meals a day; it’s healthier to eat mini meals throughout the day than one or two big meals. “Largely this isn’t based on any good science that we can find.” 17:44: Fasting can elevate ketones to high levels—eve...