Podcasts about Triple M

Dr. Monty Pal and Dr. Pauline Funchain discuss the latest efforts to diagnose, prevent, and treat the series of immune-related adverse events that have emerged in the era of immunotherapy. TRANSCRIPT Dr. Monty Pal: Hello, and welcome to the ASCO Daily News Podcast. I am Monty Pal, a medical oncologist, professor and vice chair of medical oncology at the City of Hope Comprehensive Cancer Center in Los Angeles, California. Now, it is probably no surprise to this audience that immunotherapy has transformed the treatment landscape for multiple cancer types. It remains a pillar of modern oncology. Having said that, I think we have all been baffled by certain toxicities that we run into in the clinic. Today, I am delighted to be joined by Dr Pauline Funchain to discuss some of the checkpoint inhibitor toxicities that people struggle with most. And we will also touch on some side effects of immunotherapy beyond checkpoint inhibitors: CAR-T cells, bispecifics, so on and so forth. Dr Funchain is a dear friend, and she is an associate professor and associate director of cancer research training and education at the Stanford Cancer Institute. She is co-director of the Immunotherapy Toxicity Program and the Skin Cancer Genomics Program at Stanford, where she also serves as associate program director of hematology and oncology fellowship. Dr. Funchain is also the co-founder of ASPIRE, and we are going to talk about that a little bit today, the Alliance for the Support and Prevention of Immune-Related Events. FYI for listeners, if you are interested in our disclosures, they are available at the transcript of this episode. Pauline, thanks so much for joining us today. Dr. Pauline Funchain: Monty, thank you for this invitation. It is always great to talk. Dr. Monty Pal: So, for the audience, Pauline and I know each other from my days as a fellow at City of Hope. She was a resident at Harbor UCLA and a stellar resident at that. It has just been amazing to sort of see your career grow and blossom and to witness all the cool things that you are doing. ASPIRE, in particular, sort of caught my eye. So again, for listeners, this is the Alliance for the Support and Prevention of Immune-Related Events. Can you tell us a little bit briefly about the genesis of that, how that came about? Dr. Pauline Funchain: So, there was a bunch of us who were really struggling, I mean, all of us have struggled with these immune-related adverse events, these irAEs. You know, they are new disease states, and even though they look like autoimmune diseases, they tend to need a whole lot more steroid than autoimmune diseases do and they do not totally present in the same way. And in fact, you know, Triple-M, or Triple-M overlap syndrome, is a completely new irAE, a new immune state that we have never had before the advent of checkpoint inhibitor. And so a Triple-M, for those of you who are not as familiar, that is the constellation of myocarditis, myositis, and myasthenia gravis, something that never occurs as a natural autoimmune disease. So we were starting to realize that there were some major differences with these irAEs and autoimmune diseases. We could not treat them the right way. We really needed to learn more about them. And a bunch of us who had interest in this said, "Look, we really need to be all in one space to talk about what we are doing," because all of our treatments were our own little homegrown brews, and we needed to really get together and understand how to treat these things, how to diagnose them, and then learn more about them. So, Dr. Alexa Meara from Ohio State, Dr. Kerry Reynolds from Mass Gen, we put together this research consortium, brought together all of our irAE friends, got our best subspecialists together in a research consortium, which is now only about a year and a half old. And we made this research consortium, the Alliance for Support of Prevention of Immune-Related Events, and we reached out to ASCO, and ASCO was so kind to grant us a [Alliance for Support and Prevention of Immune-Related adverse Events (ASPIRE)] Community of Practice. So we met for the first time as a Community of Practice at the ASCO Annual Meeting just this past June and really got an ASCO community together to really think about how to again, diagnose, prevent, treat irAEs. Dr Monty Pal: This is interesting to me. The ASCO Community of Practice phenomenon is something that I was not super familiar with. Can you explain to our listenership what is the ASCO Community of Practice model? If you have particular interests, how do you sort of get one started? Dr Pauline Funchain: Yeah, so ASCO has an entire page on their Community of Practice. There are multiple Community of Practice groups or COPs. There are ones for Supportive Oncology and Survivorship. There is Women in Oncology. There is a group for International Medical Graduates. And there is about, I think 10 or 12 now that have a physical presence at ASCO but also a virtual presence on the ASCO Community of Practice site. So, if you were interested in any one of these, and you can see them on the ASCO Communities of Practice sites, you would ask to become a member. Once granted membership, then there is a whole webpage of postings and conversations that people can have. You can get email digests of conversations that happen on the website, and then you can anchor it with in-person participation at the Annual Meeting. Dr Monty Pal: That is awesome, and I can think of so many different foci within oncology that really sort of deserve a Community of Practice. This definitely being one of them. You know, it strikes me as being so interesting. I mean, the checkpoint inhibitors have been around for a while now. I think when you and I were in training, gosh, back then, these were just a little bit of a pipe dream, right? But having said that, I would probably say that more than half of my kidney cancer practice is either on checkpoint inhibitors, and the vast majority have been on one at some point in their past, right? With that in mind, you know, we have all treated a lot of patients with these drugs. Why is it that we still struggle to manage the toxicities? And just to take that one step further, what are some of the toxicities that, perhaps through ASPIRE or through your experience, people struggle with the most? Dr Pauline Funchain: So, I think we are still struggling with these because again, they are new disease states, right? This is what we all experienced with COVID, a brand-new virus and a brand-new syndrome. We now have 20-plus of these as irAEs. And what we have realized about them is the immune activation that happens with these is so much more than what we have seen with autoimmune diseases. So for instance, if you have a Crohn's or ulcerative colitis, you will top out at 40 to 60 milligrams of prednisone if a Crohn's flare or ulcerative colitis flare happens. But for our severe IR colitises, you know, it is at least 1 mg per kg, often goes up to 2 mg per kg. We, in some cases, have done 1 gram pulses if we are worried that somebody is going to perforate. So that was sort of like the first 5 years of treating irAE, and then now in the sort of second 5 years of treating irAE, we have realized that that is a lot of immunosuppression, and we might be able to get away with less with the newer biologics that are on board. So, we are struggling to try to get the data for some of these irAEs that we knew, we have known for a while, but to try to get newer treatments that may immunosuppress less so that you may still be able to retain that tumor response. And in fact, some of the preclinical studies suggest that some of these biologics may actually synergize with the immunotherapy and actually make the immunotherapy more effective from a tumor perspective and calm down the irAE as sort of the bystander effect. So we are still trying to optimize those. Getting up trials in the space has been very difficult. That is one of the reasons for the genesis of ASPIRE because we realized we needed to band together to have a bigger voice in that realm. Then there are other things that are brand new. So we talked about Triple-M. So Triple-M, again, with Triple-M or any myocarditis or myasthenia, I mean, there is about a 50% chance of death from irAE based on the literature. I think we are getting better at recognizing this, and so at Stanford we have some data to say that if you serially follow troponin, that maybe your outcomes are better. You can potentially lower the percentage of cases that are fatal because you can catch them early. I mean, this is all preliminary data, but again, these are all things that are evolving, and we do not all have the right answer. I mean, even the serial troponin thing, I think, is pretty controversial. And in fact, at one of our quarterly Zoom meetings that we are doing in ASPIRE in December is going to sort of flush out that controversy about serial troponin measuring and what is the best thing to use? Would you use something like abatacept or would you use ruxolitinib? Which one is better? I think there is a lot of controversy still about these things. Dr Monty Pal: You have really piqued my curiosity here because you think about the cons of treating irAEs, right? And I worry exactly about what you had mentioned, right, which is, "Gosh, what is going on with this tumor in terms of immunosuppression?" But you think about some of the newer agents, you mentioned ruxolitinib, I have heard of dasatinib, for instance, in this setting. Frankly speaking, a lot of these, as you point out, are really thought of as being also anticancer drugs. So you have really got me thinking about the potential synergy between perhaps suppressing an irAE and augmenting antitumor activity, which I think is very interesting. Am I on the right track with that? Dr Pauline Funchain: I think so, but you will find that a lot of people will not even go there because they are worried about how much immunosuppression you are going to cause. I am at heart a geneticist, but I think an immunologist will happily tell you that the immune system is very complex. There are multiple pathways, and these drugs do not all target the same immune pathways. So if we understand a little bit more about the pathways we are targeting and pick apart the pathways that are really, really tumor relevant and the other pathways that are not tumor relevant, you may be able to piece together a better marriage of tumor response and irAE control. Dr Monty Pal: Kind of on this topic, and again, leaning on your background in genetics, where are we in terms of predicting these irAEs? I mean, you would think the holy grail would be picking out a snip or something of this for it, right, that could potentially identify that patient who is going to get Triple-M or, you know, at the very least a significant high-grade irAE event. Are we anywhere closer to that in 2025? Dr Pauline Funchain: There have been data published. There have been some big GWAS studies. All of the effect sizes are pretty small. So there are some prediction algorithms, but none of them are clinically useful. And I think when you look at the odds ratios, they will increase risk by maybe 20%. I think one of the things that we found in a very small series and supported anecdotally is something as easy as family history of autoimmune disease is probably more predictive at this point than any of those types of markers. I think we will get there, but we are not anywhere near where we would like to be. Things like TMB also, actually, there is some good data about higher TMB, higher risk of irAE too. Dr Monty Pal: Interesting. I see all this data coming through, IL-8 polymorphisms, etc. And I just wondered if any of that was ready for prime time. But I mean, this is a good message for the practicing clinician. Sounds like we are not quite there yet. And I could probably keep you on for another entire podcast to talk about this topic, but let us see if we can at least skim the surface. I never thought I would see the day when BiTEs and CAR-Ts were entering into my kidney cancer practice, but in fact, it is really become central to a lot of our clinical trials in RCC these days. I would be lying if I did not say that I was not struggling with the toxicities and so forth associated with these drugs. Can you give us a quick primer, maybe just good resources that people can go to for managing toxicity with BiTEs and with CAR and with some of these novel therapeutic modalities that we are using in the oncology clinics? Dr Pauline Funchain: I know there is a recently published toxicity manual for BiTEs in hematologic malignancies, I think it was in Blood. CAR-T is covered in many irAE guidelines. So ASCO guidelines actually has a CAR-T [cell therapy guideline], and I would be remiss not to point out that actually ASCO has a, I am a little biased, but a wonderful guideline on irAE that is actually being updated as we speak. We are hoping for publication next year. I find the format of that, there are many guidelines out there, actually. There is ASCO, SITC, ESMO has a guideline for irAE, but I find the formatting of the ASCO guideline to be much easier to flip through during clinic, just because of the visual format of the tables. But that is going to be updated next year. And with CAR-T, there is now multiple publications also in terms of guidelines. But what I will say about bispecifics and CAR-T, so they have very similar toxicities in terms of the cytokine release and also with the ICANS, so the neurotoxicity. But what we have been finding that is really interesting with BiTEs and CAR-T, and actually even with TIL, cytokine release is very similar to some of the IL-2 toxicities but not identical that we see with TIL treatment. But now we are starting to see overlap. So patients who have been treated with immunotherapy and then go on to get a bispecific or then go on to get TIL, so I have seen some colitises that have occurred after the fact. Some of the newer CAR-Ts without checkpoint have been causing some really interesting, probably not in a good way, but interesting biologically, colitises that are really refractory. So we are starting to see some overlap, and again, I think this field is just evolving constantly. Dr Monty Pal: Yeah, no, I almost think I need to go back to that fellowship that you and I did together 20 years ago and, you know, and see if I could repeat some coursework on CAR-T management.  You know, Pauline, I could probably keep you on the horn for hours, but this has just been terrific. Thank you so much for sharing all of your insights with us today on the ASCO Daily News Podcast. Dr Pauline Funchain: Thank you for the invitation. It was wonderful to talk about this, and it was wonderful to catch up a little bit, Monty. Dr Monty Pal: Same here, same here. And thanks to our listeners too. If you value the insights you heard today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:      Dr. Monty Pal    @montypal   Dr. Pauline Funchain @FunchainMD Follow ASCO on social media:       @ASCO on Twitter      ASCO on Bluesky     ASCO on Facebook       ASCO on LinkedIn     Disclosures: Dr. Monty Pal:     Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview    Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical    Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis    Dr. Pauline Funchain: Consulting or Advisory Role: Merck, Replimune, Sanofi/Regeneron, Immunocore, Tempus Research Funding (Inst.): Pfizer, Bristol-Myers Squibb, IDEAYA Biosciences, Linnaeus Therapeutics Travel, Accommodations, Expenses: Merck

FULL SHOW : TGIF and that means Mick's Dad Joke, Adam Rozenbachs will help us celebrate Clown Of The Week, Mark Waugh chats Triple M's Summer of Cricket and Mick wasn't voted Sexiest Man Alive to his dismay. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

Three becomes four - Millie’s baby Gigi is in studio today! Maroon, Millie and Hindy chat to comedy legend Harley Breen, they take your calls on where Millie should move to when she moves to Sydney and Hindy gives a farm update!See omnystudio.com/listener for privacy information.

FULL SHOW : We've managed to track down our fearless leader, Mick is in New Zealand "working", Glenn Robbins puts the toilet paper down to let us talk to his entourage. Wil Anderson stops by to talk Oasis and Golfer Cam Smith talks LIV Tournament. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

Country-rap powerhouse Jelly Roll joins Maroon & Hindy on Triple M’s Rush Hour for an unfiltered chat.See omnystudio.com/listener for privacy information.

BIG SHOW TODAY! Jelly Roll joins Maroon and Hindy, we chat to Brad Haddin about the announcement of the Ashes team, and we take your calls on what your unusual job is.See omnystudio.com/listener for privacy information.

Jelly Roll lowdown with Cam the Stadium Boss and Stat Man, plus Councillor Paul Jacob throws his hat in the ring for mayor. We also dive into why Gen Z just doesn’t want to leave home — is it comfort, cost, or something else? All that and more with Cliffo & Kate on Triple M Breakfast.Listen weekday mornings from 6–9 on 102.3 Triple M or on LiSTNR, just search Cliffo & Kate.See omnystudio.com/listener for privacy information.

FULL SHOW : Adam Rozenbachs is with us again and Roo is now a Gallagher brother, meaning we'll chat all things Oasis. AFLW Saint Kilda supercoach Nick Dal Santo joins the team to chat their finals appearance, 2025 Melbourne Cup winning jockey Jamie Melham shares her feelings from the weekend and Urzila Carlson tells us about life on a Superyacht!Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

Millie is back for a big Cup Day edition of the Rush Hour! It’s Tuesday, which means the Rush Hour’s Believe It or Not is back, Hindy crashes a recording with country superstar Shaboozey, and they chat to our mate Howie on his new cricket podcast on LiSTNR.See omnystudio.com/listener for privacy information.

Mark Howard joins Cliffo & Kate to preview the upcoming Ashes series, sharing insights on Bazball, Aussie injuries, and who might surprise us this summer. Kate dives into the mysterious world of “girl showers” — what are they and why are they so hot? Cliffo makes a dramatic breakup with Aldi (it’s not them, it’s him), and we catch up with Townsville’s most persistent mayoral candidate, Harry Patel. Listen weekday mornings from 6–9 on 102.3 Triple M or on LiSTNR, just search Cliffo & Kate.See omnystudio.com/listener for privacy information.

It’s the great Christmas decoration debate — how early is too early? Cliffo & Kate weigh in, and the answers might surprise. Plus, Kate makes a bold Melbourne Cup prediction (will she nail it?), Jelly Roll tickets are up for grabs, and The Urban List finally lands in Townsville! Also, meet mayoral candidate Joanne Keune — what’s her vision for the city?Listen weekday mornings from 6–9 on 102.3 Triple M or on LiSTNR, just search Cliffo & Kate.See omnystudio.com/listener for privacy information.

01. Thomas Gold & Barmuda - Rebel [Dim Mak]  02. Shelco - Losing My Mind [New Noise]  03. Cheyenne Giles - San Diego [Dim Mak] 04. DIM MAK PICK OF THE WEEK: PLS&TY & WHAT EVA - Demons [Dim Mak] 05. Saint Punk & MASTERIA - Dark Side [Dim Mak]  06. 4B - Haunted [Dim Mak]  07. T-Mass & Krysta Youngs - Somebody's Watching Me [Dim Mak]  08. Steve Aoki & Blasterjaxx ft Lil Jon - Get Down [Dim Mak]  09. DIM MAK NEW RELEASE PLAYLIST: Stephen Hurtley - Don't Let Me Go [New Noise]  10. Ookay - Lose Control [Dim Mak] - Proxima Nova EP 11. Mike Posner - Please Don't Go (YDG Remix) [Dim Mak]   12. Guest Mix: Triple M  1. Triple M & Eric Altair - Cynical 2. Control Room & DASHI - What's Your Motive 3. Eptic, Habstrakt - Alone 4. Triple M & Blanee - Run It Now 5. NUZB - S3XY 6. Moorad & Triple M - Care Bear 7. Chester Young & Hackatone ft. SUVI - Genesis (Don Diablo Edit) 8. Jordan Oliver & Triple M - Worry vs. Europe - The Final Countdown   13. FRIDAY FLASHBACK: Godlands - Johnny [Dim Mak] 

Maroon and Hindy are back for a big week of the Rush Hour! The team chat to rock royalty Bernard Fanning AND jockey Tom Berry, they take your calls on what words you can’t pronounce and it’s not a Monday without a moan from Maroon.See omnystudio.com/listener for privacy information.

We bring you our annual unique take on the Triple M Race Call | Bernard Fanning, always a great chat and good friend of Marto's | Bonnie Blue is heading to Schoolies!See omnystudio.com/listener for privacy information.

Who will take out this year's Triple M Race Call? Listen here to find outSee omnystudio.com/listener for privacy information.

The talented artists behind the incredible Jellyroll mural at City Lane join us to share their story—and give away a Jellyroll double pass! Plus, someone’s been adding googly eyes to mayoral candidate posters around Townsville, John the Roadie pulls off a Halloween prank, and we’ve got good news for local property owners. Listen weekday mornings from 6–9 on 102.3 Triple M or on LiSTNR, just search Cliffo & Kate.See omnystudio.com/listener for privacy information.

GOOD CHAT | Mick shocks the team by revealing his teeth brushing routine (or lack there of!), we'll discuss which TV Show had the worst ending, Adam Rozenbachs wants to know the thing we never want to do again, what would you take form the MCG and there'll be some harsh words on if you should put your toaster away when you're done using it. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch Mick in the Morning in action, head to YouTube.See omnystudio.com/listener for privacy information.

It’s the Friday edition of the Rush Hour with Maroon, Millie Elliot and Adam Peacock! The team chat to NRL superstar Adam Reynolds, they take your calls on the best money saving hacks and Brad Haddin joins the show to chat all things cricket!See omnystudio.com/listener for privacy information.

FULL SHOW : Mick's away so Adam Rozenbachs is in his place. Melbourne Cup winning jockey Michelle Payne stops by to chat all things racing, speaking of racing apparently Billy Brownless owns part of a horse. Roo talks Halloween celebrations in America, weve got Mick's dad joke and we'll wrap it up nicely with the Week That Was.Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

The crew (Maroon, Millie and Hindy) are back together for Halloween eve! Isaac-eats-a-lot is back to tell us the best 5 pies in Sydney, Hindy gives us a farm update, and they take your suggestions on what the bet between Hindy and Maroon should be for Hindy’s weight loss challenge.See omnystudio.com/listener for privacy information.

Mayoral hopeful Ann-Maree Greaney joins us for a candid chat about her vision for Townsville. Stat-Man is back with another cheeky quiz to test your trivia chops. Plus, the PRB reps swing by the studio bringing all the fun Cowboy vibes ahead of the weekend action. And Kate? She’s home alone with no kids — and loving every second of it!Listen weekday mornings from 6–9 on 102.3 Triple M or on LiSTNR, just search Cliffo & Kate.See omnystudio.com/listener for privacy information.

We sit down with controversial mayoral candidate Troy Thompson for a chat that’s anything but boring. Paddy Pool joins us to talk about Fuel for Schools and the incredible impact it’s having on local kids. Plus, we round up the news you missed — the weird and wacky headlines that’ll make you laugh (or cry). And Daniel’s Law officially passes Queensland Parliament, a major step forward for Queensland. Listen weekday mornings from 6–9 on 102.3 Triple M or on LiSTNR, just search Cliffo & Kate.See omnystudio.com/listener for privacy information.

FULL SHOW : Oasis have touched down and we've got your last tickets, we'll touch base with the 11 'Reece Police' that are on the beat, there'll be a Good Chat about horrible television show endings and we will find out that weird places you've watched the Melbourne Cup. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

Maroon and Hindy get a little saucy today on the Rush Hour! They chat to Dale from Boom Crash Opera, Hindy delivered a bit of a naughty Hollywood Goss, and they take your calls what nice thing you partner does that you hate.See omnystudio.com/listener for privacy information.

FULL SHOW : Albo was in trouble for wearing a Joy Division t-shirt, so we wanna know your fave band shirts, CEO of VRC Kylie Rogers joins us to chat all things Melbourne Cup and Hughesy stops by to tell us about how much fluid he still has in his lung. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

Millie Elliot joins Maroon and Hindy for the Rush Hour. They chat to the Superwog duo, they try and amaze you with their ‘Believe it or Not’ segment and they take your calls on when you faked it.See omnystudio.com/listener for privacy information.

FULL SHOW : A conversation about overrated Sports movies leads us to find what the best one is, we'll learn that not everyone had a great school excursion. Lehmo stops by to chat golf and why are Titus' kids needing photos of him? Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

Maroon and Hindy are back from a big weekend! They chat to Paul Dempsey, they take your calls on what you ate and how long it took you to eat it, and Maroon has a story about Josh Reynolds wedding that you don’t want to miss!See omnystudio.com/listener for privacy information.

FULL SHOW : Tortillas being thrown at a football match, bare knuckle ice hockey fights, Coles is playing opera,VCE exams, What the F and Malaphors are all covered on the pod and Dave O'Neil will stop by to talk about his thinner brother Glenn. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

We're looking back at our favourite moments from 2025 and beyond. John Longmire calls in and hears Billy's Craft from the 2024 Grand Final, Billy gets Sucked In, we want to send you to the Supercars BP Adelaide Grand Final, Greg Rust previews the Mexico GP and pays tribute to a Supercars legend, Billy calls a game of footy, Jackson Warne joins the show, Billy hosts a new quiz, Stifler's Mom and Bily recreate the famous seduction scene from American Pie, and we hear a joke from the supermarket.See omnystudio.com/listener for privacy information.

FULL SHOW : Jim Jefferies joins us to also tryo to get to the bottom of Mick's new show, We ask for your dad jokes, Rosie quizes the boys on Bear or Boss and Adam Rozenbachs will help us celebrate Clow of the Week! Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

GOOD CHAT | Our favourite biopic, Titus wants to know the deal with different kinds of sausage flavours, can men wear dots, should there be a women only section on the plane and we'll find out everyone's favourite solo activity.....no, not like that! Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch Mick in the Morning in action, head to YouTube.See omnystudio.com/listener for privacy information.

The Friday gang is back with Maroon, Millie Elliot and Adam Peacock! The team chat to Supercross legend Hayden Mellross ahead of the event at Shark Park, Maroon has very strong views on service station etiquette, and they take your calls on the worst prize you’ve ever won!See omnystudio.com/listener for privacy information.

I had an absolute blast chatting with former Aussie cricketer, expert commentator, and podcast host Greg Blewett on Legends with Bevo! We covered heaps of great topics including:The much-anticipated upcoming Ashes series here in AustraliaWhat it was like for Blewy to face West Indies pace legends Curtly Ambrose and Courtney WalshSouth Australia's drought-breaking Sheffield Shield and ODI wins earlier this yearHis new podcasts and passion projectsAnd how much he's loving life in the commentary box with Triple M and Channel 7Blewy was an absolute legend to chat with, and cricket fans are going to love this one! Thanks so much to Blewy for his time and a big thanks to the team at Podbooth for a great job of putting the episode together. A huge thankyou also to our loyal series sponsors Steve Chapman from VH Motor Co and Ryan Bridges from Elders Goolwa.

FULL SHOW : Guests galore with Jon Stevens, Lanard Copeland and Glenn Robbins join us, we'll find out what was your first car and will Mick actually tell us any information about his new Channel 7 show? Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

Joel Madden of Good Charlotte joins Maroon & Hindy on Triple M’s Rush Hour to celebrate the band’s long-awaited return to Australia with their new album Motel Du Cap. After seven years between records and eight years since their last Aussie tour, Joel reflects on how time away from the stage reignited the band’s passion and gave their sound a fresh edge. He opens up about his love for Australia, what he misses most about being down under, and what fans can expect when Good Charlotte finally hit our shores again.The chat also dives into the inspiration behind Motel Du Cap — a wedding in the south of France that brought the band back together — and, of course, a wild story of the only fist fight Joel has ever had with his twin brother Benji backstage in Germany.See omnystudio.com/listener for privacy information.

FULL SHOW : Get to the chopper! New top cop Mike Bush has been critiqued for using the Police Helicopter, we'll talk Ye Olde Crimes and Crazy Sports Contracts plus we'll get to the bottom of Jeremy Allen White singing Bruce Springsteen classics. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

It’s a big Tuesday edition of the Rush Hour with Maroon and Hindy! They chat to Aussie music legend Pete Murray, the Rush Hour’s Believe it or Not is back for another week, and Maroon takes your advice on how to he eject guests from his house when he is ready for them to leave!See omnystudio.com/listener for privacy information.

FULL SHOW : Melbourne we wanna know What Makes You Rage? Mick asked the team to watch The Golden Bachelor but little did he know they already had a Team Chat happening without him and Tim McDonald from The Cheap Seats stops by to chat Albo in the States. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

It’s Monday already, so a brand-new week for the Rush Hour with Maroon and Hindy on board! The team chat to Tony Armstrong, it’s not Monday without a Monday Moan and Hindy teaches (well tries to teach) Maroon about the 6-7 meme!See omnystudio.com/listener for privacy information.

FULL SHOW : Mick was in Perth for a Telethon and helped raise $90 million, Roo picked up a bird over the weekend and Titus was at the Moto GP with his 12 year old daughter who got to meet bigger superstars than Thor! Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

We look back at some of our favourite moments from 2025, plus a couple of moments from even further back. Dangerous Dave takes us through his favourite Ozzy Osbourne moments, Ross Noble drops by, and we reflect on the most disgusting story Billy has ever told. The worst topic of 2025 gets a re-run, the Chief Jason Dunstall calls in after being inducted into yet another Hall of Fame, we remember Fat N Skinny's Ad Agency, we play some of Tuesday's Dwayne Russell interview that you didn't hear, and Billy has a joke about cricket.See omnystudio.com/listener for privacy information.

GOOD CHAT | What a range of topics we covered this week, from being in quicksand to the rules of what to do in the toilet. Even Dangerous Dave stops by to tell us about his favourite spread....no not Cosmo. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch Mick in the Morning in action, head to YouTube. And for a laugh-fuelled feed, follow @molloy and @triplemmelb on Instagram. Remember to like and share!See omnystudio.com/listener for privacy information.

FULL SHOW : It's Roo's Birthday, but do the rest of the team know? Mick went to the cinema by himself but people still sat too close to him, Adam Rozenbachs is back from an oversease jaunt and helps us celebrate Clown Of The Week. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

Aussie Swimming legend Ariarne Titmus joined Mick In The Morning after yesterday announcing her unexpected retirement from the pool. Considered one of the greatest middle-distance swimmers of all time, Titmus explains her decision to hang up the goggles at the age of 25 - and what's in store next for the Aussie role model. Catch Mick in the Morning, with Roo, Titus & Rosie LIVE from 6-9am weekdays on 105.1 Triple M Melbourne or via the LiSTNR app. Mick In The Morning Instagram: https://www.instagram.com/molloy Triple M Melbourne Instagram: https://www.instagram.com/triplemmelbSee omnystudio.com/listener for privacy information.

FULL SHOW : We'll have a good chat about things you believed as a kid that really aren't that true, Xander McGuire is back to round up all those trade developments, Mick reluctantly dives deep into Taylor SWift's new album and Dr. Chris Brown let's us know how to survive a bear attack. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

FULL SHOW : Big Day for the AFL and Xander McGuire is in to talk all things trading, Nathan Buckley is on the move to Geelong, we wanna know who is the most famous person in your phone contacts and Roo will find out what he can't face. Catch Mick in the Morning LIVE from 6-9am weekdays on 105.1 Triple M. To watch your favourite new Breakfast Radio crew in action, follow @molloy and @triplemmelb on InstagramSee omnystudio.com/listener for privacy information.

Billy and Daisy are back in studio after an epic Bathurst 1000, and the All Sports Report features AFL trade news and Australia's amazing Women's World Cup win. We want you to pump yourself up with Monday Brag Artist, then Geelong's Tom Stewart is in studio to reflect on the Cats' Grand Final loss, and how he managed his GF week knowing he'd miss the game with concussion. Bathurst 1000 winner Matt Payne calls in from the Mountain, and Billy has his top 5 moments from Triple M's Call of the Great Race. World Athletics Championship Bronze Medallist Jess Hull is in studio as she begins to look forward to the Commonwealth Games, and Billy gives us two short and sharp jokes to close the show.See omnystudio.com/listener for privacy information.

We're looking back at some of our favourite moments from JB and Billy this year and in years gone by. Today we revisit the Wacky World of William, Carlton's Sam Docherty, Billy being snubbed for a team of the century, World Surfing Champion Molly Picklum, the birth of the Rush Hour's most famous catch-phrase, an Idiot Song, and Billy's Joke featuring St Kilda's Callum Wilkie.See omnystudio.com/listener for privacy information.

Respected Motorsport engineer and Data Analyst Scott Sinclair joins us at Bathurst to look at some of the key considerations for Sunday’s Great Race. He worked with James Courtney back in 2010 when he won the title for Dick Johnson Racing and listner’s may also know him from stints with the Holden Racing Team and more recently with Kelly Racing’s Nissan program. These days he lends his expertise to the Supercars TV team helping the commentators tell the strategic story of the races and he provides fans with excellent exclusive content for the sport’s official website. His latest column talks about what you need for success at the Bathurst 1000 and why it’s more than luck. https://www.supercars.com/news/expert-analysis-supercars-2025-bathurst-1000-strategy-explained-double-stack-pit-stop-ford-hopes Fittingly Rusty and Scott talked as it began to rain at Bathurst. From the impact of wet weather, the value of the pre-event track walk, tyres, safety cars, having a closely matched co-driver, pitstops for brakes and fuel, plus the benefit of a little motivational radio chat. Enjoy some of the engineering considerations ahead of this weekend’s Bathurst 1000 which you can listen too on our sister network Triple M as Rusty joins Daniel Leach live from Mount Panorama for the top 10 shootout on Saturday and the big race on Sunday. Head to Rusty's Facebook, Twitter or Instagram and give us your feedback and let us know who you want to hear from on Rusty's GarageSee omnystudio.com/listener for privacy information.