Podcasts about addison's disease

This week on The Pet Buzz, Petrendologist Charlotte Reed and Michael Fleck, DVM, talk with author and journalist Steven Haskin about the outcome of the 147th Kentucky Derby; with veterinarian Dr. Steven Friedenberg of the College of Veterinary Medicine, University of Minnesota about Addison's disease; and with author and cat behaviorist Beth Adelman and author and dog trainer Babette Haggarty about the Bidens adding a cat to their family in light of German Shepherd Major's biting personality.

Today's listener requested topics are taken from @rdexampodcast and cover diverticulosis vs diverticulitis, Addison's disease, sensitivity vs specificity. This episode is sponsored by Pocket Prep. Questions:  A high-fiber diet is contraindicated for which of the following disease states? Diverticulitis Diverticulosis Constipation Obesity Which of the following is generally increased in Addison’s disease? Aldosterone Cortisol Androgens Potassium Which of the following is known to correctly identify participants as not having a disease? Sensitivity Specificity Both A and B None of the above  

Hello and Welcome to Dr Jones’ Veterinary Secrets PODCAST – this is episode 111! In today’s episode..Massive Pet Food Recall from Midwestern Pet Foods. Addison’s Disease- what is it and how you can help your dog. 4 Essential Oil Recipes for Dogs. The FDA link of all Recalled Pet Food is here: https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/midwestern-pet-foods-voluntarily-recall-due-possible-salmonella-health-risk Dr Jones’ Veterinary Secrets is on all your favorite podcast apps, including Spotify, iTunes and Stitcher-I would sure appreciate it if you would subscribe to my podcast, and leave a review. Questions or suggestions? Feel free to post a comment about this podcast episode on the blog at www.theinternetpetvet.com  I encourage you to get a copy of my New FREE Book ‘Natural Health for Dogs and Cats’ in which I share the most important remedies to keep your pet healthy and naturally treat disease You can get your copy here http://www.veterinarysecrets.com  

Addison's Disease: How Hygienists Can Help Spot Oral Signs By Meghan Greening, RDH, BSDH, EFDA Original article published on Today's RDH: https://www.todaysrdh.com/addisons-disease-how-hygienists-can-help-spot-oral-signs/ Podcast audio article sponsored by LISTERINE® brand. Be the first to know the latest from LISTERINE® brand when you join LISTERINE® OFFICE ESSENTIALS® Program at http://rdh.tv/listerine. LISTERINE® OFFICE ESSENTIALS® Program offers exciting new content that explores topics meaningful and relevant to your practice, including tips on communicating with your patients, as well as ideas to help you grow your dental practice. Please note, although a sponsor of this audio article, LISTERINE® Brand and Johnson & Johnson Consumer Inc. had no input into or control over the content being presented. Get daily dental hygiene articles at https://www.todaysrdh.com Follow Today's RDH on Facebook: https://www.facebook.com/TodaysRDH/ Follow Kara RDH on Facebook: https://www.facebook.com/DentalHygieneKaraRDH/ Follow Kara RDH on Instagram: https://www.instagram.com/kara_rdh/

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:  Traci: Is there a scientific reason as to why we should start the fatlossity System and use for 21 days prior to detox? Thanks so much! Jackie: Hi- On episode 498 anonymous asked about little red dots on her arms. Dr. Cabral referred anonymous to episode 464 where MariEllen asks about raised bumps on her legs. I feel like these might be two different things. Is there any other episode where Dr. Cabral talks specifically about flat dots on the arms? Or, could you give some information about the cause and possible remedy of smooth, red dots on the backs of the arms that have been there for years? Thanks for all of your work!!! -Jackie Carol: I heard on the podcast that dr Cabral has suffered from Addison’s disease, as I do. He alludes to his terrible illness at 17, but does not go into any detail about what it is, and I am very interested to know if he was able to cure it, and also if the detox would be right for me. Thank you Anonymous: Hi Dr. Cabal. I recently got a semen analysis as my wife and I have been having a hard time trying to conceive. My results came back good but this is from a western medicine stand point. Could you please let me know what the ideal ranges would be from a functional medicine perspective? The areas they reported on were semen volume, sperm concentration, motility and morphology. Also can you please discuss some natural ways in which I can improve on my results. For context I have completed the big 5 labs along with the recommendations. I have continued on with the level 2 daily protocol with healthy eating and exercise most days. Thank you. Sabrina: Hi! I’ve been binge listening to the podcasts for a month or so and learning so much. My family and I are nearing the end of the h-pylori protocol that was outlined in one of the podcasts. My mother has been dealing with candida issues for 30 years and has tried many diets and supplements with no lasting results. She is very interesting in doing Doctor Cabral’s Candida protocol, but her concern is that she seems to have a sensitivity to Oregano and Olive Leaf. When we did the h-pylori protocol with the essential oils, she had muscle and joint pain for over a month until she removed the Oregano oil from her routine. Her concern is that she doesn’t want to spend all of that money on the candida protocol only to have a reaction to the oregano in the blends. Do you have any suggestion for how she should proceed? Thank you so much for your help! Sabrina Anonymous: Hello Dr. Cabral! What do you think about the treatment Miradry to reduce underarm sweating? I know sweating is good for detoxification but Id rather go to the sauna than soak through my shirts every day. Thank you so much! Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community’s questions!  - - - Show Notes & Resources: http://StephenCabral.com/1499 - - - Get Your Question Answered: http://StephenCabral.com/askcabral   - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -   Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox  (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake  (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend  (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil  (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements  - - -   Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test  (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. 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In today's VETgirl online veterinary continuing education podcast, we discuss dosing intervals for desoxycorticosterone pivalate, better known as DOCP, in dogs with hypoadrenocorticism (more commonly called Addison's disease). As many of you have likely experienced, the cost of DOCP can be quite high, particularly for our larger patients.

In today's VETgirl online veterinary continuing education podcast, we discuss dosing intervals for desoxycorticosterone pivalate, better known as DOCP, in dogs with hypoadrenocorticism (more commonly called Addison's disease). As many of you have likely experienced, the cost of DOCP can be quite high, particularly for our larger patients.

Host Natasha and special guest Yolanda talk about Yolanda's experience with Addison's Disease! It isn't easy! Tune in and listen to her story! --- Send in a voice message: https://anchor.fm/tharemedy/message

My notes on: Cushing's Disease and Addison's Disease Pheochromocytoma and Hyperaldosteronism Let's remember, these bad boys are my notes, they aren't perfect. Sometimes I'm not perfect and I cannot read. Sometimes I can't even speak. Either way I hope this helps you in your studies!

Addison's disease is a condition in which the adrenal glands do not produce enough hormones. The study guide covers the key areas that you will need to know for nursing school. Check out the study guide at nursingsurvival.com. ·        Disease Process:   ·        Causes   ·        Signs and Symptoms   ·        Diagnosis   ·        Complications ·        Treatment   ·        Nursing Considerations   ·        Patient Education  

I was sent this link (https://ndnr.com/autoimmuneallergy-medicine/addisons-disease/) by a sister Addisonian. I was really shocked at how broken down this was. I have never came across an article that was so informative. I learned so much and I really wanted to share it with those who are suffering from Addison's Disease or know of someone who is. I read through the article (please excuse the pronunciation of things, I know I butchered so much of it) and give a little bit of info about what I was told/not told, tests that were ran or not ran for me, and what steps I want to take to make this disease less of a burden on my body. Please check out the link as well. Advocate for yourselves and don't take "i dont' know or your results look normal" for an answer. You know your body better than any doctor. Also at https://linktr.ee/chronicmomsclubProducts: https://linktr.ee/ilenabickley

I read from Addison's Disease to address. Do you know why the 14 century plays such a big role in the English we speak these days?  If so, please send me a message on one of these forms of social media.  I'm also going to look it up myself.  dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://twitter.com/dictionarypod https://www.patreon.com/spejampar

 Become A Health Coach-Learn More About The Institute for Integrative Nutrition's Health Coaching Certification Program by checking out these four resources: 1) Integrative Nutrition's Curriculum Guide: http://geti.in/2cmUMxb 2) The IIN Curriculum Syllabus: http://geti.in/2miXTej 3) Module One of the IIN curriculum: http://geti.in/2cmWPl8 4) Get three free chapters of Joshua Rosenthal's book: https://bit.ly/2wgkLOU Watch my little video on how to become a Certified Health Coach! https://www.youtube.com/watch?v=CDDnofnSldI   Dr. Christianson's video on how to do a neck/thyroid exam: https://www.youtube.com/watch?v=_VDsmkRliXI www.drchristianson.com Book - Metabolism Reset Diet https://amzn.to/2Dh2qVS   Heal Your Thyroid Holistically learntruehealth.com/heal-your-thyroid-holistically To heal your thyroid holistically is not as complicated as it seems. There have also been numerous opinions on whether iodine is good or bad for our health in the long run. To enlighten us about how to heal your thyroid holistically and other health issues linked to our thyroid, I’m so happy to have Dr. Alan Christianson back on the show. Dr. Alan Christianson has helped so many people over the years addressing thyroid and adrenal issues. A significant component of how to holistically heal your thyroid is through the right diet. That’s why Dr. Alan Christianson wrote the book, The Metabolism Reset Diet, which is launching on January 29. Thyroid Health Dr. Alan Christianson says thyroid health does affect a lot of systems in the body. Especially brain development on kids. And to date, he says it’s been estimated that there’s a lot of billion people on planet earth who didn’t get the brain function they deserve because they lacked iodine as they grew up. And whenever the topic is about how to heal your thyroid holistically, iodine often comes up.  For those who are unaware, iodine is one of the first elements that is ever isolated. The name itself comes from the violet color the element has. “The thyroid medication contains active thyroid hormones. And they are built from iodine. And getting too much can seem a lot like too little regarding how it affects the body,” explains Dr. Alan Christianson.  He adds, “The amount that you need is about a hundredfold of what you find in the bloodstream. So, the bloodstream concentrates iodine. And the concentrator is important because it’s a nutrient that you wouldn’t get on a consistent basis. But the pitfall about that concentrator is that if we get a lot of it, we shut down the factory.” Too Much or Too Little Iodine? Before you embark on the journey of how to heal your thyroid holistically, there’s a lot of tests available in the market to aid you in finding the best solution. There are spot urine tests, which means random samples of urine is analyzed. Dr. Alan Christianson also shares that there are the 24-hour urine test and a recent thing called iodine challenge test. The iodine challenge test is where you take a big dose and see how much you excrete in the time afterward. “A lot of those tests are decent to gauge how much iodine a population has. So, if you were to go to Central Africa and screen a thousand people with spot urinary iodine test, you get a good hunch,” said Dr. Alan Christianson. “But because there is so much variation in any one person’s random urine sample, you have to test thoroughly.”    He adds, “Some of the best tests would only require about 200 tests for one person to have 90% of accuracy. So, there are no good tests, but thankfully there’s also no known human diversity regarding iodine absorption or excretion.” Diet Choices To heal your thyroid holistically, diet is a critical component. Dr. Alan Christianson reveals that one population can be at risk for getting low iodine if their food is more stringent and that’s pregnant women. And with the healthy intake of seafood and a good variety of produce in the diet, it’s easy not to become deficient. The other group that can be at risk are raw food vegans who don’t use any iodine-fortified salt. Dr. Alan Christianson likes sea salt for general use because this way, you get some magnesium. So, if someone was consuming no animal products and especially just raw foods, they can get low iodine. “Sea vegetables are rich in iodine. Most forms of sea vegetables have enough to be useful but not enough to throw your way out of the ballpark,” said Dr. Alan Christianson. “Kelp helps a lot. Tiny amounts could be useful. Nori has pretty reasonable amounts of iodine.” Dr. Alan Christianson also mentioned that by adding iodized salt to food, people could get reasonable amounts. He also said that pretty much all multi-vitamins will have between a hundred or two hundred micrograms.  Too Much Iodine While On Medication Dr. Alan Christianson explains that if someone is between their supplements, their diet, and medication, it creates more overall resistance to thyroid hormones in their body. So, the amounts that we need regarding thyroid and iodine are a small quantity, like one to two hundred micrograms or a tenth of a grain of salt. “Some studies show that megadose iodine is an effective treatment for fibrocystic breast disease. We have to think through side effects, and thyroid complication as whether or not is it worth it overall,” said Dr. Alan Christianson. Hashimoto’s Disease A Japanese physician discovered Hashimoto’s because the Japanese have the highest rates of autoimmune thyroid disease and thyroid cancer. According to Dr. Alan Christianson, they also have the world’s highest iodine intake. In the U.S., Dr. Alan Christianson reveals that we have a lot of goiter cases especially in a lot of great lakes and areas where there is a lot of fresh water. But we didn’t have autoimmune thyroid disease. “The thing with Hashimoto’s as an autoimmune disease, if you don’t see it then you don’t know that it’s not there,” Dr. Alan Christianson said. “So, people have hypothyroidism, and sometimes the doctor may test for thyroid antibodies. Half the time, the thyroid antibodies are negative.”  He adds, “But people who have Hashimoto’s disease, half the time their thyroid antibodies never show up. So, there are few cases of hypothyroidism that are not autoimmune.” Graves’ Disease Graves’ disease, on the other hand, is also known as toxic diffuse goiter. It is an autoimmune disease that affects the thyroid. Based on numerous case studies, it often results in and is the most common cause of hyperthyroidism. Apart from that, it frequently results in an enlarged thyroid. “The part about being hyperthyroid perpetuates the autoimmune attack. You may see odd things that may not be helpful but seems to be effective for one person,” Dr. Alan Christianson explains. “And with more appropriate treatment, in pulling someone out of hyperthyroidism and getting iodine right, many can heal and stay stable again.”  He adds, “It’s not about the pill. The question is always can I be vital and happy and thriving again. So, focus on that one. It’s really about how you’re going to feel and function.” Advocating For Ourselves Dr. Alan Christianson says the patient’s well-being is most important. But thyroid levels also affect health in ways that you wouldn’t know based on symptoms alone. Your TSH signal, for example, that’s a growth signal to the thyroid. And it can be a growth signal for something connected with health issues like heart disease and diabetes. “So, it’s important to monitor our thyroid levels annually, to make sure we’re not getting too much or too little. Cancer that’s growing the fastest among women is thyroid cancer. The rates have gone up since the end of the 90s. It has gone up three-fold,” shares Dr. Alan Christianson. Dr. Alan Christianson also believes that people with thyroid disease should have a minimum of a baseline ultrasound when the thyroid is down. The American College of Gynecology, in fact, recommends self-neck checks on a monthly basis as part of wanting to heal the thyroid holistically.  Nutrient Deficiencies Dr. Alan Christianson stressed that selenium is essential for all things thyroid. Those who are low in selenium are more likely to have an iodine deficiency and vice versa. “So, it’s most important to get a screen for your TSH and your thyroid antibodies. And it’s important to know not just what’s normal but what should optimal look like,” said Dr. Alan Christianson. “There’s a certain amount of thyroid antibodies that are considered perfectly fine.” Other Measures Dr. Alan Christianson says the number of people who have thyroid problems is much higher than people who have perfect thyroid function. And when you look at the healthiest populations, their average scores of T4 and T3 pretty much are the average scores in the blood test. T3 and T4 are highly regulated by the body, and they only reflect the state when the body is off by extremes. On the other hand, T2 is not measurable. Dr. Alan Christianson says healthy people have reasonable amounts of that. People who are on thyroid treatment that does not include T2, tend to be lacking in it. He also said that T2 by itself seems to have the most significant roles to play in metabolic rates, and also would regulate ovarian function. Truth About Cortisol There have also been references wherein popularized the idea of how the adrenals are unable to produce cortisol. Dr. Alan Christianson mentions that there’s a disease called Addison’s disease. He went on to say that at a surface look, someone with Addison’s disease could have very similar cortisol levels to another. “If you assume the problem is low cortisol, somebody is likely to think of giving more cortisol. And a lot of cases like that where someone is giving you a lot of cortisol at your worst, you might feel a lot better short-term,” said Dr. Alan Christianson. “But you can also measure the brain talking to the adrenals, in the same way, the brain talks to the thyroid.” And the difference between Addison’s disease and adrenal fatigue is that in adrenal fatigue, the brain is telling you to slow down. That’s why Dr. Alan Christianson believes that prognosis can differ from person to person. Hence, in wanting to heal your thyroid holistically, one has to do the research apart from finding an excellent practitioner who is knowledgeable. Ultimately, it’s about how to become a self-advocate for your health. “Stay active with their work and hold on to it. You can radically transform the quality of your life by doing the right things with your lifestyle. Don’t give up on having that vision come through for you,” said Dr. Alan Christianson.  Bio  Dr. Alan Christianson is a Naturopathic Endocrinologist who focuses on Thyroid function, adrenal health, and metabolism.  Dr. Alan Christianson has been actively practicing in Scottsdale since 1996 and is the founding physician behind Integrative Health. He is a NY Times bestselling author whose books include The Metabolism Reset Diet, The Adrenal Reset Diet, and the Complete Idiot’s Guide to Thyroid Disease.  Dr. Alan Christianson regularly appears on national media like Dr. Oz, The Doctors, and The Today Show. Get Connected With Dr. Alan Christianson! Official Website Facebook Instagram Pinterest YouTube Thyroid Self-Exam Books by Dr. Alan Christianson Adrenal Reset Diet     Metabolism Reset Diet   ************************************ Learn How To Achieve Optimal Health From Naturopathic Doctors! Get Learn True Health's Seven-Day Course For FREE! Visit go.learntruehealth.com http://go.learntruehealth.com/gw-oi   ************************************ Do You Have Anxiety? End Anxiety Now! Learn Two Powerful Mind Tricks for Removing Anxiety, Ending Worry, & Controlling Fear So It Stops Controlling You! Attend my FREE Webinar that Will Teach You How! Click Here! http://FreeYourAnxiety.com/webinar ************************************ Need Help Ordering The Right Supplements For You? Visit TakeYourSupplements.com, and a FREE health coach will help you! http://takeyoursupplements.com Do you have a blood sugar issue? 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Double the Neil's Of The Weird. Double the Taste of the UKs. Enjoy! We apologize for the length of the Episode this week as well as the lack of Microsodes.  Chris suffered the loss of one of his dogs, Inky.  She will be missed as she knew nothing but how to love her humans, siblings, puppies and anyone else she encountered.  She was diagnosed with Addison's Disease and had been receiving treatments.  However, life isn't fair and she passed away quietly and suddenly.  She will be missed.

Dr Merrianne Burtch, Pacific Veterinary Specialists & BirchBark Foundation This is a report to correct the audio not being properly attached! Addison's Disease is a fairly common condition in dogs and horses that results from a lack of steroids being produced by the body. It is the same disease in people and is the opposite of the more common (in dogs) Cushing's Disease, where too many steroids are produced by the animal. This is an almost 14-minute discussion of Addison's with Dr. Merrianne Burtch of Pacific Veterinary Specialists in Capitola and is part of our regular series of discussions of animal health issues.

Did you ever record your own family while they sat down to dinner to eat? It was kind of a thing in the 1970s. It was also kind of a thing back in the 1960s as well. But, in this case, this wasn't an ordinary family dinner.  That's because this dinner was held at then Senator John F. Kennedy's house in Washington, DC. The occasion for this January 5, 1960 dinner? A sort of celebration and look forward to the 1960 presidential campaign, for which JFK had just declared himself a candidate. In addition to the Kennedys, the party featured Washington Post honco Ben Bradlee, his wife Toni Bradlee and James Cannon, a reporter for Newsweek magazine.  Luckily for history (and This is the President), Cannon brought along a portable tape recorder and recorded the dinner conversation for posterity. There's a few interesting tidbits here, including Kennedy's take on his role in politics and a denial of having Addison's Disease (which he did, in fact, have).  In addition, of course, there's lots of other goodness from Scott and Harmon, including their takes on the Korea talks, the Royal Marriage Conspiracy and the Oldest Pub in London. 

A bouquet of debilitating and chronic illnesses, coupled with the birth of a son and the death of a father brought Matt Gagnon to his knees. Addison's Disease, narcolepsy, and traumatic brain injuries halted this retail rockstar's rise through the ranks of corporate America. In this episode, Matt shares how illness brought his family to the brink of financial ruin and how his supply line formula for wellness has restored his faith and his family's financial security. Today, Matt and his wife each run successful independent businesses. Read more about Matt Gagnon’s story.

This week, I tackle a question sent in by a listener about Addison’s disease in dogs. I’ll address prognosis and treatments so you know what to expect with this diagnosis. I also share some practical home remedies to use on your pets including for allergies and skunks. Finally, I’ll discuss the most common behavior issues we see in pets: anxiety and noise phobias with specific natural products to help your pet cope – all on this week’s episode of Animal General with Dr. Mike Hutchinson! Ask Dr. Mike -You can submit your questions to be asked and answered on a future podcast here! contact@drmikehutchinson.com ABOUT THE PODCAST The “Animal General Podcast” with Dr. Mike will navigate you through the world of pets with tips and tricks, time-tested veterinary medicine and new cutting-edge procedures. Join Dr. Mike Hutchinson to discuss all of your pet needs! From more complex topics like stem cells and regenerative medicine to simple solutions for ridding your pet of that nasty skunk smell... Find the answers - and how they translate to your own beloved pet!   MISC NOTES * FOR ALL EMERGENCY VETERINARY ISSUES Please contact the Animal General Veterinary Hospital Ph 724-776-7930 Email info@animalgeneral.net http://www.animalgeneral.net Episodes are archived are free to listen 24/7/365 nationwide. Audio-On-Demand in-your-hand, smartphone, tablet, laptop and desktop computers. Available to APPLE users on iTunes and the Podcasts application Available to ANDROID users on Google Play Music Available to ALL users via Stitcher, TuneIn, and http://drmikehutchinson.com/ * SEARCH: “Animal General with Dr. Mike” SPECIAL THANK YOU to Carl Herkes of Data Innovations for the great website and logo design. Website: http://data-innovat.com/ Comprehensive IT and Design Services Specializing in Small Business Infrastructure (Located in Orange County, CA) Animal General with Dr. Mike is exclusively managed by Talent Network, Inc. and produced by Pittsburgh Podcast Network.   Episode 16 | October 2, 2017

Dogs (and cats) having a crisis as a result of hypoadrenocorticism (Addisonian crisis) can be in a life-threatening state and this represents one of the true small animal emergencies. Stabilisation of these patients starts with appropriately aggressive intravenous fluid therapy as the first priority and treatment for clinically significant hyperkalaemia and hypoglycaemia may also be needed very early on. Intravenous glucocorticoids are typically then required to continue stabilisation. In this episode I discuss ten talking points relating to canine hypoadrenocorticism, namely: “The Great Pretender” Likely Genetic Basis Aldosterone may be low in ‘atypical’ cases Hypoglycaemia may be severe Bradycardia is not always present and not just due to hyperkalaemia ACTH stimulation test provides definitive diagnosis Single resting plasma cortisol may be useful for screening – but limited role in emergencies? Intravenous fluid therapy Client communication and education Prognosis is good with appropriate management – yey!   Click Here For Your FREE Copy of a Transcript of This Episode   PAPERS that helped inspire some of the content for this episode are: Baumstark ME, Sieber-Ruckstuhl NS, Mϋller C, et al. Evaluation of Aldosterone Concentrations in Dogs with Hypoadrenocorticism. J Vet Intern Med 2014; 28:154–159. (Open access online) Boag AM, Catchpole B. A Review of the Genetics of Hypoadrenocorticism. Topics in Companion Animal Medicine 2015 (Accepted manuscript pending publication). Bovens C, Tennant K, Reeve J, Murphy KF. Basal Serum Cortisol Concentration as a Screening Test for Hypoadrenocorticism in Dogs. J Vet Intern Med 2014; 28:1541–1545. (Open access online) Lennon EM, Boyle TE, Hutchins RG, et al. Use of basal serum or plasma cortisol concentrations to rule out a diagnosis  of hypoadrenocorticism in dogs:  123 cases (2000–2005). J Am Vet Med Assoc 2007; 231:413–416. (Abstract)

Background: Three genes have been confirmed as major joint susceptibility genes for endocrine autoimmune disease: human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 and protein tyrosine phosphatase non-receptor type 22. Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD). Methods: The aim of the present study was to investigate the role of the rs1990760 polymorphism within the IFIH1 gene in German patients with GD (n = 258), Hashimoto's thyroiditis (HT, n = 106), Addison's disease (AD, n = 195) and healthy controls (HC, n = 227) as well as in 55 GD families (165 individuals, German) and 100 HT families (300 individuals, Italian). Furthermore, the interaction between rs1990760 polymorphism with human leukocyte antigen (HLA) risk haplotype DQ2(DQA*0501-DQB*0201), the risk haplotypes DQ2/DQ8 (DQA*0301-DQB*0302) and the status of thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb) and TSH receptor antibody (TRAb) in patients and families were analysed. Results: No significant differences were found between the allele and genotype frequencies for rs1990760 IFIH1 polymorphism in patients with GD, HT, AD and HC. Also no differences were observed when stratifying the IFIH1 rs1990760 polymorphism for gender, presence or absence of thyroid antibodies (GD: TRAb and HT:TPOAb/TgAb) and HLA risk haplotypes (DQ2: for GD and HT, DQ2/DQ8: for AD). Furthermore the transmission analysis in GD and HT families revealed no differences in alleles transmission for rs1990760 IFIH1 from parents with or without HLA risk haplotype DQ2 to the affected offspring. In contrast, by dividing the HT parents according to the presence or absence of thyroid Ab titers, mothers and fathers both positive for TPOAb/TgAb overtransmitted the allele A of IFIH1 rs1990760 to their HT affected offspring (61.8% vs 38.2%; p = 0.05; corrected p [pc] = 0.1). However, these associations did not remain statistically significant after correction of the p-values. Conclusion: In conclusion, our data suggest, no contribution from IFIH1 rs1990760 polymorphism to the pathogenesis of either Graves' disease, Hashimoto's thyroiditis or Addison's disease in our study populations. However, in order to exclude a possible influence of the studied polymorphism in specified subgroups within patients with autoimmune thyroid disease, further investigations in larger populations are needed.

We investigated the effect of sodium valproate on plasma ACTH and serum cortisol concentrations in different pathological states of ACTH hypersecretion. Five patients with pituitary dependent Cushing's syndrome, two patients with Nelson's syndrome and five patients with Addison's disease were studied. Neither a single dose nor long term administration of sodium valproate resulted in a significant decrease of plasma ACTH levels in patients with Cushing's disease and Nelson's syndrome. Furthermore, the response of ACTH and cortisol to stimulation with lysine-vasopressin was unaffected during acute and chronic treatment. Patients with Addison's disease showed a slight attenuation of the ACTH response to lysine-vasopressin as compared to placebo but the difference was not statistically significant. In conclusion: sodium valproate does not appear to be effective in controlling ACTH hypersecretion in pituitary dependent Cushing's syndrome.