Podcasts about Narcolepsy

Send us Fan MailFrom fighting university registration portals for 4 hours to realizing your mom isnt just “mom”,this episode gets real about parent-child dynamics, adulting struggles, and living with narcolepsy.David w/ special guest Johnna and her daughter Danica open up about what it was really like growing up with undiagnosed narcolepsy and idiopathic hypersomnia. Plus, they unpack the infamous "Sleeping Beauty" award from middle school, why we try to put our 60-year-old parents in nursing homes, and the wild reality of navigating college degrees as an adult. #Survivingish #SurvivingishPodcast #Narcolepsy #IdiopathicHypersomnia #ParentingYourParents #PodcastEpisode #MentalHealthAwareness #TrueCrimeJournals #Descript #CollegeRegistration #ParentChildRelationshipSupport the show

Narcolepsy is one of those amazing rare disorders that everyone thinks they understand – people just fall asleep at random times, even in the middle of doing something. But there’s a lot more to it and – even better – we actually may be able to explain it. Josh and Chuck run it down in this classic episode.See omnystudio.com/listener for privacy information.

Nature staff discuss how an FDA-approved drug for narcolepsy could have promise beyond the condition, and the longest-lived human brain organoids yet.00:28 The promise of a new narcolepsy drugNature: First-of-its-kind narcolepsy drug opens door to new therapies for the brain05:53 Human brain organoids kept alive for over five yearsNature: Human organoids that mimic brain development grown for years in lab​​​​​​​Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today's episode delves into the latest innovations and strategic shifts propelling the industry forward. A notable dialogue emerging in psychiatric drug development comes from TLDR Biotech's engagement with Shlomi Raz and Ken Belotsky, co-founders of Palomar Labs. This conversation heralds a transformative shift in psychiatric treatments, moving beyond traditional psychedelics toward novel approaches deeply rooted in human experience. Initially inspired by the therapeutic potential of psychedelics such as psilocybin, early research, notably from Johns Hopkins, sought to establish these compounds within a biopharmaceutical framework. Despite historical evidence supporting their efficacy, challenges persisted in reclassifying these Schedule I substances as viable therapies. Raz and Belotsky, pioneers in this initial psychedelic wave, now lead efforts at Palomar Labs to develop next-generation therapeutics targeting serotonin receptors without the hallucinogenic effects typical of classical psychedelics. This approach seeks to dismantle longstanding industry biases against specific receptor targets known as "anti-targets." A critical concept in their methodology is "neuroplastogens," as popularized by David Olson at UC Davis. These compounds are believed to induce beneficial neuroplastic changes without causing hallucinations. However, Palomar Labs exercises caution, viewing neuroplasticity not as a definitive biomarker for therapeutic efficacy but rather as one of many aspects to consider. Their unconventional "reverse" drug development model begins with anecdotal human experiences and is validated backward through preclinical animal models before advancing to clinical trials. This method relies on overlooked data sources—such as discarded trial reports and traditional medicine use cases—to uncover therapeutic candidates traditionally ignored due to biases against certain receptor targets. For example, they explore therapies for Parkinson's disease bypassing direct dopamine receptor modulation and treatments for Alzheimer's-related aggression avoiding heavily sedative antipsychotics. Palomar Labs' venture studio model emphasizes disciplined capital allocation and an unbiased approach to research outcomes. By prioritizing drug candidates with strong evidence from human experiences, they aim to swiftly advance promising therapies to proof-of-concept stages, readying them for further development by pharmaceutical partners or venture-backed entities. This paradigm shift from target-centric development to a model grounded in empirical human data represents a significant advancement in psychiatric drug discovery. In other industry news, Replimune has successfully navigated regulatory hurdles to secure FDA approval for its melanoma therapy, Tudriqev, following two prior rejections. This achievement underscores the resilience required in drug development and strategic regulatory engagement. The approval highlights the potential of oncolytic virus therapies—Tudriqev employs an innovative approach by using viruses to selectively infect cancer cells while sparing healthy tissue, simultaneously stimulating an immune response. Meanwhile, Eli Lilly continues its dominance in the obesity treatment market with Zepbound, despite new oral competitors. The enduring preference for injectable solutions highlights established efficacy and safety profiles that continue to resonate with healthcare professionals. In China, TransThera has gained regulatory approval for a bile duct cancer treatment, marking a significant step forward for Chinese innovation in oncology. Such advancements not only diversify treatment options but also elevate China's status as a pivotal contributor to global drug development. Challenges persist across the sector, exemplified by Fresenius Kabi's recall of a mislabeled morphine lot due to overdose risks. This incident underscores the vital importance of stringent quality control measures essential for patient safety. The biopharmaceutical landscape also sees Takeda securing FDA approval for its first-in-class orexin receptor agonist targeting narcolepsy—a testament to innovative approaches addressing unmet needs in sleep disorders. Amidst these developments, BioMarin has opted to terminate its $270 million rare disease asset following unsatisfactory Phase 3 results. Such decisions highlight the inherent risks within drug development pipelines and underscore the necessity for strategic flexibility. Leadership changes are shaping corporate trajectories too; BioNTech's appointment of Guido Oelkers as CEO exemplifies this trend. His experience will likely drive strategic realignments crucial for navigating complex industry challenges. Finally, the industry's focus on digital transformation is evident through Bausch + Lomb's partnership with VerilyMe—a collaboration aimed at enhancing dry eye education via digital and AI technologies. These stories collectively embody the dynamic nature of the pharmaceutical and biotech industries—where regulatory achievements, strategic pivots, and technological advancements are continuously redefining therapeutic landscapes and enhancing patient care worldwide. As we continue navigating this rapidly evolving field, staying informed on these developments is crucial for leveraging opportunities and addressing challenges within this innovative sector.Support the show

In Part 2, we explore what it was really like navigating childhood and adolescence with narcolepsy. From school, friendships, routines, and the challenges of being misunderstood, this episode offers an honest look at the realities of living with narcolepsy from a young age.

Moderna's mRNA influenza vaccine gains FDA approval; approvals for prostate cancer, narcolepsy type 1 and Mucinex 12HR; and peanut allergy treatment gains Fast Track status.

Pediatric Narcolepsy Challenges, Opportunities, and Emerging Therapies On this episode host Amy Lugo, PharmD, BCPS, BC-ADM, FAPhA, FAMCP, Founder and CEO of LoneStar Health Solutions, is joined by Dr. Joshua Lennon, Assistant Professor at the University of Tennessee Health Science Center, to discuss the unique challenges of diagnosing and treating narcolepsy in children. They explore why pediatric narcolepsy is frequently misdiagnosed, the significant delays many patients experience before receiving an accurate diagnosis, and the impact untreated symptoms can have on learning, social development, and long-term health. The conversation also examines current FDA-approved treatment options, promising advances in orexin-targeted therapies, and the important role managed care professionals play in improving timely access to evidence-based care for children living with narcolepsy.

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsCore Sleep Paralysis ScienceSharpless, Brian A., and Jacques P. Barber. “Lifetime Prevalence Rates of Sleep Paralysis: A Systematic Review.” Sleep Medicine Reviews 15, no. 5 (2011): 311–315.Sharpless, Brian A. “A Clinician's Guide to Recurrent Isolated Sleep Paralysis.” Neuropsychiatric Disease and Treatment 12 (2016): 1761–1767.Cheyne, J. Allan, Steve D. Rueffer, and Ian R. Newby-Clark. “Hypnagogic and Hypnopompic Hallucinations during Sleep Paralysis: Neurological and Cultural Construction of the Night-Mare.” Consciousness and Cognition 8, no. 3 (1999): 319–337.Cheyne, J. Allan. “Sleep Paralysis and the Structure of Waking-Nightmare Hallucinations.” Dreaming 13, no. 3 (2003): 163–179.Cheyne, J. Allan. “Situational Factors Affecting Sleep Paralysis and Associated Hallucinations: Position and Timing Effects.” Journal of Sleep Research 11, no. 2 (2002): 169–177.Solomonova, Elizaveta. “Sleep Paralysis: Phenomenology, Neurophysiology and Treatment.” In The Oxford Handbook of Spontaneous Thought: Mind-Wandering, Creativity, and Dreaming, edited by Kieran C. R. Fox and Kalina Christoff. Oxford University Press, 2018.Baland Jalal / Panic-Hallucination / TreatmentJalal, Baland. “How to Make the Ghosts in My Bedroom Disappear? Focused-Attention Meditation Combined with Muscle Relaxation (MR Therapy): A Direct Treatment Intervention for Sleep Paralysis.” Frontiers in Psychology 7 (2016): 28. doi:10.3389/fpsyg.2016.00028.Jalal, Baland, and V. S. Ramachandran. “Sleep Paralysis and ‘The Bedroom Intruder': The Role of the Right Superior Parietal, Phantom Pain and Body Image Projection.” Medical Hypotheses 83, no. 6 (2014): 755–757.Jalal, Baland. “The Neuropharmacology of Sleep Paralysis Hallucinations: Serotonin 2A Activation and a Novel Therapeutic Drug.” Psychopharmacology 235, no. 11 (2018): 3083–3091.Jalal, Baland, Lucia Moruzzi, Andrea Zangrandi, Matteo Filardi, Claudio Franceschini, Fabio Pizza, et al. “Meditation-Relaxation (MR Therapy) for Sleep Paralysis: A Pilot Study in Patients with Narcolepsy.” Frontiers in Neurology 11 (2020): 922. doi:10.3389/fneur.2020.00922.Folklore, Myth, and the Old HagHufford, David J. The Terror That Comes in the Night: An Experience-Centered Study of Supernatural Assault Traditions. Philadelphia: University of Pennsylvania Press, 1982.Hufford, David J. “Sleep Paralysis as Spiritual Experience.” Transcultural Psychiatry 42, no. 1 (2005): 11–45.Adler, Shelley R. Sleep Paralysis: Night-mares, Nocebos, and the Mind-Body Connection. New Brunswick: Rutgers University Press, 2011.Davies, Owen. “The Nightmare Experience, Sleep Paralysis, and Witchcraft Accusations.” Folklore 114, no. 2 (2003): 181–203.Bond, John. An Essay on the Incubus, or Nightmare. London: Printed for D. Wilson and T. Durham, 1753.Golzari, Samad E. J., et al. “Sleep Paralysis in Medieval Persia — The Hidayat of Akhawayni (?–983 AD).” Neuropsychiatric Disease and Treatment 8 (2012): 229–234.Cross-Cultural Sleep ParalysisHinton, Devon E., Vuth Pich, Dara Chhean, and Mark H. Pollack. “‘The Ghost Pushes You Down': Sleep Paralysis-Type Panic Attacks in a Khmer Refugee Population.” Transcultural Psychiatry 42, no. 1 (2005): 46–77.Hinton, Devon E., Vuth Pich, Dara Chhean, Mark H. Pollack, and Richard J. McNally. “Sleep Paralysis among Cambodian Refugees: Association with PTSD Diagnosis and Severity.” Depression and Anxiety 22, no. 2 (2005): 47–51.Jalal, Baland, and Devon E. Hinton. “Rates and Characteristics of Sleep Paralysis in the General Population of Denmark and Egypt.” Culture, Medicine, and Psychiatry 37, no. 3 (2013): 534–548.Jalal, Baland, Joseph Simons-Rudolph, Bamo Jalal, and Devon E. Hinton. “Explanations of Sleep Paralysis among Egyptian College Students and the General Population in Egypt and Denmark.” Transcultural Psychiatry 51, no. 2 (2014): 158–175.Jalal, Baland, Andrea Romanelli, and Devon E. Hinton. “Cultural Explanations of Sleep Paralysis in Italy: The Pandafeche Attack and Associated Supernatural Beliefs.” Culture, Medicine, and Psychiatry 39, no. 4 (2015): 651–664.Olunu, Esther, Ruth Kimo, Esther Olufunmbi Onigbinde, Mary-Amadeus Uduak Akpanobong, and Inyene Ezekiel Enang. “Sleep Paralysis, a Medical Condition with a Diverse Cultural Interpretation.” International Journal of Applied and Basic Medical Research 8, no. 3 (2018): 137–142.Sensed Presence / Body Map / Shadow Person NeuroscienceArzy, Shahar, Margitta Seeck, Stephanie Ortigue, Laurent Spinelli, and Olaf Blanke. “Induction of an Illusory Shadow Person.” Nature 443 (2006): 287.Blanke, Olaf, Stephanie Ortigue, Theodor Landis, and Margitta Seeck. “Stimulating Illusory Own-Body Perceptions.” Nature 419 (2002): 269–270.Blanke, Olaf, Theodor Landis, Laurent Spinelli, and Margitta Seeck. “Out-of-Body Experience and Autoscopy of Neurological Origin.” Brain 127, no. 2 (2004): 243–258.Ionta, Silvio, Lukas Heydrich, Bigna Lenggenhager, Michael Mouthon, Eleonora Fornari, Dominique Chapuis, Roger Gassert, and Olaf Blanke. “Multisensory Mechanisms in Temporo-Parietal Cortex Support Self-Location and First-Person Perspective.” Neuron 70, no. 2 (2011): 363–374.Blanke, Olaf, Polona Pozeg, Masayuki Hara, Lukas Heydrich, Andrea Serino, Akio Yamamoto, Toshiro Higuchi, et al. “Neurological and Robot-Controlled Induction of an Apparition.” Current Biology 24, no. 22 (2014): 2681–2686.Alien Abduction / Modern Mythic MaskMcNally, Richard J., and Susan A. Clancy. “Sleep Paralysis, Sexual Abuse, and Space Alien Abduction.” Transcultural Psychiatry 42, no. 1 (2005): 113–122.Clancy, Susan A. Abducted: How People Come to Believe They Were Kidnapped by Aliens. Cambridge, MA: Harvard University Press, 2005.Blackmore, Susan. “Abduction by Aliens or Sleep Paralysis?” Skeptical Inquirer 22, no. 3 (1998): 23–28.Clinical Sleep / Narcolepsy / REM BackgroundAmerican Academy of Sleep Medicine. International Classification of Sleep Disorders. 3rd ed., text revision. Darien, IL: American Academy of Sleep Medicine, 2023.Scammell, Thomas E. “Narcolepsy.” New England Journal of Medicine 373, no. 27 (2015): 2654–2662.Saper, Clifford B., Patrick M. Fuller, Nigel P. Pedersen, Jun Lu, and Thomas E. Scammell. “Sleep State Switching.” Neuron 68, no. 6 (2010): 1023–1042.Brooks, Patricia L., and John H. Peever. “Identification of the Transmitter and Receptor Mechanisms Responsible for REM Sleep Paralysis.” Journal of Neuroscience 32, no. 29 (2012): 9785–9795.Avidan, Alon Y., and Phyllis C. Zee, eds. Handbook of Sleep Medicine. Philadelphia: Lippincott Williams & Wilkins, 2011.Visual / Art HistoryFuseli, Henry. The Nightmare. 1781. Oil on canvas. Detroit Institute of Arts.Myrone, Martin. Gothic Nightmares: Fuseli, Blake and the Romantic Imagination. London: Tate Publishing, 2006.Powell, Nicolas. Fuseli: The Nightmare. London: Allen Lane, 1973.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. 

Send us Fan MailS6 E137 Narcolepsy Treatment Is Changing: Orexin Drugs + Sleep StrategiesNarcolepsy treatment may be entering a new era. In this episode of Sleep Takeout, Dan and Michelle explore how new orexin-targeted medications could change the treatment of narcolepsy type 1 by addressing the underlying orexin, also called hypocretin, deficiency rather than managing each symptom separately.They explain what narcolepsy is, why it disrupts both daytime alertness and nighttime sleep, and how symptoms may include excessive daytime sleepiness, fragmented nighttime sleep, vivid dreams, hypnagogic or hypnopompic hallucinations, sleep paralysis, and cataplexy. Narcolepsy type 1 is associated with low orexin levels and includes cataplexy, while narcolepsy type 2 typically occurs without cataplexy.Dan and Michelle also discuss orexin receptor agonists, an emerging class of narcolepsy medications designed to restore orexin signaling in the brain's sleep-wake system. The episode highlights oveporexton, formerly TAK-861, an investigational oral orexin receptor 2 agonist being studied for narcolepsy type 1. Clinical trials have examined its effects on excessive daytime sleepiness, wakefulness, cataplexy, nighttime awakenings, and other symptoms.They also review earlier research involving danavorexton, formerly TAK-925, an intravenous orexin receptor 2 agonist studied for its wake-promoting effects in people with narcolepsy type 1 and narcolepsy type 2.Medication is only one part of narcolepsy management. This conversation also covers practical behavioral strategies that may help people manage symptoms and improve daily functioning, including:• Brief, strategically scheduled naps• A consistent bedtime and wake time• Reducing stimulation before bedtime• Cognitive behavioral therapy for narcolepsy• Responding differently to discouraging thoughts about symptoms• Avoiding heavy meals and large amounts of sugar when they worsen daytime alertness• Working with a sleep medicine specialist to develop an individualized treatment planWhether you live with narcolepsy, support someone who does, or want to understand the future of sleep medicine, this episode offers an accessible look at narcolepsy symptoms, orexin medications, cataplexy treatment, CBT, strategic naps, nutrition, and emerging research.Chapters00:00 Remote Recording and Behind-the-Scenes Banter00:19 The Future of Narcolepsy Treatment02:31 What Is Narcolepsy?03:26 Cataplexy, Sleep Paralysis and Hallucinations05:30 How Orexin-Targeted Drugs Work06:03 Oveporexton, TAK-861 and the Takeda Pipeline07:54 Behavioral Treatment for Narcolepsy08:30 Strategic Naps and a Consistent Sleep Schedule11:19 CBT for Narcolepsy and Managing Discouraging Thoughts12:41 Diet Tips for Daytime Alertness13:55 Key Takeaways and Final ThoughtsDisclaimerThis podcast is intended for educational purposes and is not a substitute for individualized medical advice, diagnosis, or treatment. Investigational medications have not necessarily received FDA approval. Speak with a qualified sleep medicine professional about treatment decisions.#Narcolepsy #Orexin #sleepdisorders ✨ Real rest isn't just about falling asleep, it's about feeling at ease again. I'm Dr. Daniel Baughn, sleep psychologist and co-host of Sleep Takeout. I help professionals and high-achievers who seem to have everything together on the outside but can't quite turn off their minds at night. Sometimes, a simple conversation can be the start of real change.

Broadcast from KSQD, Santa Cruz on 6-25-2026: Dr. Dawn devotes the show's opening to ivermectin for COVID. She walks through critical thinking principles—considering the source, cross-verification, and recognizing self-interested claims—before reviewing the evidence. The most-cited 2021 Bulgarian study of 300 people showing 77% reduction lacked accessible methods, and larger trials capable of detecting even small benefits failed to confirm efficacy. On safety, the standard 12mg parasitic dose every few weeks is well-tolerated due to the blood-brain barrier and efflux pumps that keep ivermectin out of the brain, but daily long-term dosing has caused encephalopathy, liver and kidney damage, and birth defects. Critical drug interactions—macrolide antibiotics, verapamil, proton pump inhibitors, and beta blockers—disable the efflux mechanism, and high-fat meals increase absorption 2.5-fold. Dr. Dawn shares two inflammation formulas calculable from any CBC. The Systemic Inflammatory Index (neutrophils × platelets ÷ lymphocytes) flags runaway inflammation: 200-500 is good, above 900 warrants investigation and correlates with worse stroke outcomes and rising tumor burden. The SIRI (neutrophils x monocytes ÷ lymphocytes) detects chronic tissue inflammation and early innate immune activation: below 500 is good, above 1500 indicates trouble and correlates with cardiovascular mortality and arterial plaque from M1 macrophage activity. Dr. Dawn shares two takeaways from the Institute for Functional Medicine annual conference: in patients at high cardiovascular risk by cholesterol, each gram daily of combined EPA/DHA produces a 9% risk reduction, with bruising as the dose-limit signal. Additionally, a 15-minute walk within 30 minutes of a meal nearly eliminates postprandial inflammation. An emailer asks whether an endocrinologist's claim that vitamin D leaches calcium from bones is true. Dr. Dawn confirms that very high vitamin D (above 150 nanograms, with concern starting above 90) elevates 1,25-vitamin D, which stimulates osteoclast formation and increases C-telopeptide markers of bone breakdown. A crowdsourced question asks how histamines work in women. Dr. Dawn explains histamine functions as a CNS neurotransmitter promoting alertness, wakefulness, and pain perception (deficient in narcolepsy), and as a GI signal driving acid secretion, motility, and visceral sensation. Gut bacteria can convert histidine to histamine, and fish left to spoil can trigger anaphylactic-like reactions from accumulated bacterial histamine. She notes stomach acid treatments Tagamet and Zantac are H2 blockers rather than the more familiar H1 antihistamines, and confirms histamine correlates with hormones but not particularly with minerals. A crowdsourced question on B vitamins for women in their mid-twenties prompts Dr. Dawn to recommend prenatal vitamins for those who might become pregnant, and B100 complex with calcium taken with a little apple cider vinegar for those on restricted diets or eating mostly fast food. Another question asks about chest versus belly breathing. Dr. Dawn explains babies demonstrate proper diaphragmatic breathing (belly protrudes on inhalation) while accessory muscle use signals fight-or-flight—or pneumonia in a non-crying infant. Chest breathing raises adrenaline; belly breathing calms it in adults. How do I stop compulsive scratching? Dr. Dawn explains neurodermatitis has its own ICD-10 code alongside compulsive nail-biting and hair-pulling, and it is diagnosed by sparing of unreachable areas like the mid-back between shoulder blades. Treatment includes nail clipping, lubricants, covering scabbed areas, and Prozac—which uniquely among antidepressants has a secondary indication for neurodermatitis. Zurich researchers combined immature human nerve cells with magnetic nanoparticles to create 6-micrometer NPC bots that can be magnetically positioned at spinal cord injury sites and then triggered by pulsatile magnetic stimulation to mature into nerve tissue. Mice with severed spinal cords regained movement and brain-muscle electrical signals by day 34 after daily 30-minute treatments. A study of 15,000 people with myalgic encephalomyelitis/chronic fatigue syndrome identified eight genetic regions distinguishing them from controls. Two relate to immune response to infection—consistent with the post-infectious onset many sufferers describe, including roughly half of long COVID patients—and others link to the nervous system and chronic pain. Dr. Dawn frames ME-CFS as an immune system stuck in the "on" position, unable to brake against an enemy that is long gone. An emailer asks about prostate biopsy approaches. Dr. Dawn explains the new transperineal biopsy (through skin between scrotum and anus) reduces post-biopsy infection from 1.5% to near zero and eliminates prophylactic antibiotics, though it requires more anesthesia and time. Cancer detection rates match the transrectal approach when both use MRI targeting, and she expects the transperineal approach to become standard.

Awakening the Future: How Emerging Narcolepsy Type 1 Therapies Are Redefining Care and Expectations On this episode guest host Steve Kheloussi, PharmD, MBA, FAMCP, principal consultant at Kheloussi Consulting, speaks with Amy Lugo, PharmD, BCPS, BC-ADM, FAPhA, FAMCP, founder and CEO of LoneStar Health Solutions, about the evolving treatment landscape for narcolepsy. The discussion explores the burden of delayed diagnosis, the real-world impact of excessive daytime sleepiness and cataplexy, and how treatment may shift from symptom management toward addressing the underlying disease process. Steve and Amy also examine formulary considerations, patient-reported outcomes, utilization management challenges, and how managed care organizations can balance access, value, and patient-centered care as new therapies enter the market. Find all of our network podcasts on your favorite podcast platforms and be sure to subscribe and like us. Learn more at www.healthcarenowradio.com/listen

Narcolepsy is often described as a disorder of excessive daytime sleepiness, but that description only tells part of the story. Many people living with narcolepsy also struggle with fragmented, restless, and unrefreshing sleep at night; and these symptoms that can look a lot like insomnia. In recent years, researchers have increasingly viewed narcolepsy as a disorder of sleep-wake instability, where the boundaries between wakefulness, non-REM sleep, and REM sleep become less secure. Understanding narcolepsy through this lens helps explain why someone can be profoundly sleepy during the day and still feel like they "can't sleep" at night. In this episode we will:Explore why disrupted nighttime sleep is considered a core symptom of narcolepsy, not merely a side effect Discuss the role of orexin (hypocretin) in stabilizing sleep and wake states and what happens when that system fails Examine the surprising overlap between narcolepsy and insomnia symptoms, including frequent awakenings, vivid dreaming, and nonrestorative sleep Review key research supporting the concept of sleep-state instability as a unifying explanation for many narcolepsy symptoms Consider how treatments aimed at improving nighttime sleep consolidation may help patients feel more alert and functional during the dayTo find out more about this week's podcast sponsor Sleep Reset, please use the following link: https://www.thesleepreset.com/podcastOriginal intro music Vigilanteology by Abhinav Singh (copyright 2026) Original outro music Vigilanteology (reprise) by Abhinav Singh (copyright 2026)Produced by: Maeve WinterMusic by: Dr. Abhinav Singh (@sleep_vigilante), all rights reservedMoreTwitter: @drchriswinterIG: @drchriwinterThreads: @drchriswinterBluesky: @drchriswinterThe Sleep Solution and The Rested ChildThanks for listening and sleep well!

Episode 2322 - This episode starts exactly where civilized society collapses: discussions about Hot Girl Summer logistics, post-breakup weight loss predictions, and whether men and women are even allowed to understand each other anymore.  Kid and the crew bounce between cultural double standards, algorithm-driven outrage, media polarization, and the weird pressure modern society puts on everybody to immediately pick a side and stay angry forever. Hat Trick unloads stories involving co-parenting headaches, relationship dynamics, motel meetups, and the complicated balance between emotional connection and casual fun.  That leads into conversations about infatuation, limerence, jealousy, and why modern relationships feel like a chemistry experiment mixed with social media warfare. The back half of the episode swerves into late-night TV nostalgia, Stephen Colbert's Bay City connection, conspiracy-fueled political rants, AI paranoia, listener-line insanity, and Kid realizing he's spent 2,300 episodes collecting human weirdness like a raccoon dragging shiny garbage into a garage studio.

This episode of Gobsmacked! features Ruth Mary Chipperfield, an award-winning jeweller whose gold jewellery has sat alongside some of the most celebrated names in history.Diagnosed with narcolepsy in her early twenties whilst studying chemistry at university, Ruth found herself facing a future very different from the one she had imagined. Powerful drug regimes solved one problem whilst creating others, and as a newlywed she was confronted with a stark reality, mainstream working life simply was not going to fit.But Ruth has done something remarkable.Instead of allowing narcolepsy to define the boundaries of her life, she transformed her scientific mind, her fascination with gemstones and her artistry into something beautiful. Today, she creates and repurposes exquisite jewellery, breathing new life into old treasures whilst building a life that works with her condition rather than endlessly battling against it.Like the facets of a beautifully cut diamond, this conversation refracts in so many fascinating directions. Chemistry. Gemstones. Ketogenic living. Punishing medication. Endurance. Reinvention. Identity. Survival.At one point Ruth says:“I've chosen my hard.”Blimey, she is articulate.And this really is an absolute must-listen. Hosted on Acast. See acast.com/privacy for more information.

At this stage it's probably more common than not to have some kind of wearable tracker to track your steps, heart rate, and the one we're discussing today - sleep. They give you data showing how long you've slept, how much time you spent in each of the sleep stages, and some will even provide you with your heart rate variability and how much sleep you'll need based on your stats for the day. But are the really as useful as they seem? Or do they provide the every day person with too much insight to stress over? LISTEN ABOVESee omnystudio.com/listener for privacy information.

In this reflection I explore my recent sickness as an act of purging toxic elelements from my psychological/spiritial life.   Supporting themes:  Sleep cycles; Narcolepsy; Paranormal Phenomenon; Limits of science and Western culture; Identity barriers; DIKW (Data, Information, Knowledge, Wisdom); Low frequency vs high frequency living; Dying process; Sensation fixes (food, etc.); Empathy and empathic experiences.    Typology:  INTJ8; Se-grips; Ni-insight (INTJ vs INFJ). 

“If narcolepsy has no cure… then how does an NFL draft prospect just casually say it doesn't affect him anymore?”That single question sends Kevin “KT” Turner spiraling down a hilarious, emotional, and genuinely fascinating rabbit hole, as he shares the story of NFL draft prospect Ahkeem Mesidor, who claims that he had narcolepsy growing up but it doesn't affect him anymore.

Recent medical updates highlight the long-term health benefits of the universal hepatitis B birth dose, alongside FDA milestones including the approval of Optune Pax for pancreatic cancer and a pembrolizumab-based regimen for platinum-resistant ovarian cancer, and the granting of priority review to oveporexton for narcolepsy type 1.

Welcome to the wonderful, winding world of Schauer Thoughts! This week we're meandering through new research from MIT on the rest and digest system, as well as making a sharp turn into “womb envy.” Is the rest and digest system related to womb envy? Not really. I mean, potentially? There is definitely a glandular route through the endocrine system, but I'm not taking that road today! Today I'm just covering two separate topics because I wanted to! Huzzah. Tear. Pour. Live More. Go to https://LIQUIDIV.com and get 20% off your first order with code SCHAUER at checkout. “Wait, so what are today's separate topics?” Rest & digest and then “womb envy.” Thank you again for joining me in the communal Schauer! There's a joke to be made about “womb envy” and a “baby Schauer” - please let me know if you come up with anything solid! Enjoy the episode.  Nuance for why I “don't want to get philosophical,” spoiler! It's not because I don't like philosophy, it's because we're going to get into “zero-sum” thinking and game theory and this is where people are going to argue about what economic systems are the “best” and people feel *compelled* to play devil's advocate.  Resources:  Behave: The Biology of Humans at Our Best and Worst - Robert M. Sapolsky Could It Be ADHD or… Narcolepsy? - Discover Science, November/December 2025 Edition Cancer Spreads at Night - Lea Milling Korsholm, Exploring Science Squishy Math - Kelsey Houston-Edwards, Scientific American, Ultimate Math Edition, Fall/Winter 2025 The Denial of Death - Ernest Becker  Your brain does something surprising when you don't sleep https://www.sciencedaily.com/releases/2026/01/260119234937.htm Article from Jan. 20 Attentional failures after sleep deprivation are locked to joint neuromuscular, pupil and cerebrospinal fluid flow dynamics https://www.nature.com/articles/s41593-025-02098-8 Parietal alpha frequency shapes own-body perception by modulating the temporal integration of bodily signals  https://www.nature.com/articles/s41467-025-67657-w Scientists Found the Brain Rhythm that Makes Your Body Feel Like Yours  https://www.sciencedaily.com/releases/2026/01/260114080325.htm#:~:text=Researchers%20at%20Karolinska%20Institutet%20studied,sense%20of%20self%20is%20disturbed.%22 REM alpha rhythm: diagnostic for narcolepsy? (2006 - a bit dated) https://pubmed.ncbi.nlm.nih.gov/16751726/  FDA Clears First Blood test Used in Diagnosing Alzheimer's Disease https://www.fda.gov/news-events/press-announcements/fda-clears-first-blood-test-used-diagnosing-alzheimers-disease  Europe's Journal of Psychology https://ejop.psychopen.eu/index.php/ejop/article/view/110/110.pdf Learn more about your ad choices. Visit podcastchoices.com/adchoices

Episode 201: Automate Your Lead Generation with our FREE online course: https://go.digitaltrailblazer.com/auto-leads-course-freeReaching new audiences on Instagram without spending a fortune on ads feels nearly impossible for most business owners, leaving you stuck in an echo chamber of the same followers while fresh prospects remain out of reach.In this episode, Michelle Weger reveals a new Instagram feature that most creators are completely overlooking - one that delivered her 2.2 million views on a single post without spending a dime.She walks us through her counterintuitive strategy for using this feature in ways Instagram never intended, how to identify which content to repurpose for maximum impact, and why you only need 25 minutes per day to implement this game-changing approach.About Michelle Weger: Michelle Weger is a Productivity Expert, Resilience Speaker, and AI & Business Automation Strategist with over 14 years of proven success. Following her narcolepsy diagnosis in her early twenties, Michelle channeled that challenge into a driving force for business building and relied on automation to sustain the lifestyle she needed and to maximize every moment of wakefulness. Michelle founded Venture Creative Collective, web development and business automation agency that has generated millions in revenue despite the challenges of her living with a disability. Her bestselling memoir, “Don't Snooze Your Dreams: Lessons from Life with Narcolepsy”, has topped charts in Canada and the United States. Recognized as one of the youngest winners of Ottawa's Forty Under 40, Michelle has shared her stories and insights on CBC's Marketplace, CTV Your Morning and You Can't Ask That. She travels the world alongside her Great Dane service dog Quinn, inspiring audiences to transform perceived limitations into opportunities for growth.Check out Michelle's Book “Don't Snooze Your Dreams” for FREE here: https://michelleweger.com/dont-snooze-your-dreams-book/sample/Connect with Michelle:https://michelleweger.com/ https://www.instagram.com/daneonaplane/ https://www.instagram.com/michelleaweger/ https://www.tiktok.com/@adaneonaplane https://www.linkedin.com/in/michelleaweger/ Want to SCALE your online business bigger and faster without the endless hustle of networking, referrals, and pumping out content that nobody sees?Grab our Ultimate Ad Script for Coaches, Agencies, and Course Creators.Learn the exact 5-step script we teach our clients that allows them to generate targeted, high-quality leads at ultra-low cost, so you can land paying customers and clients without breaking the bank on ad spend. Grab the Ultimate Ad Script right HERE - https://join.digitaltrailblazer.com/ultimate-ad-script✅ Connect With Us:Website - https://DigitalTrailblazer.comFacebook - https://www.facebook.com/digitaltrailblazerTikTok: https://www.tiktok.com/@digitaltrailblazerX (Twitter): https://x.com/DgtlTrailblazerInstagram: https://www.instagram.com/DigitalTrailblazer

I'm joined by Michelle Weger, the first guest I've ever had on the show who lives with narcolepsy, for a powerful conversation about invisible illness, fear, productivity, rest, and what it really takes to keep moving forward when your energy is limited and misunderstood. Michelle is a productivity expert, bestselling author, and international keynote speaker. Throughout our conversation you'll hear her share what daily life with narcolepsy actually looks like, how receiving her diagnosis upended the identity she thought she had, and how she rebuilt confidence and purpose one practical step at a time.  We talk honestly about fear, perfectionism, procrastination, vulnerability, and why rest is not optional, especially for women in leadership. This is a conversation about doing what you can with the energy you have, letting go of shame, and redefining success on your own terms. In this episode, you'll hear: What living with narcolepsy is really like, including chronic exhaustion, disrupted sleep cycles, and why “sleepy” is very different from “tired” (3:36) How Michelle's diagnosis changed her life overnight, including losing her driver's license and the identity she thought she was building (10:08) Why fear doesn't disappear as you grow, and how learning to move through it is more important than trying to eliminate it Practical ways to work through procrastination and perfectionism (15:09) What Michelle has learned from working alongside her Great Dane service dog, Quinn, including lessons about asking for and receiving help (33:54) How to balance ambition, productivity, and energy limits, especially for women in leadership (37:32) Common misconceptions about invisible conditions like narcolepsy and why there is no one-size-fits-all experience or solution (39:35) Resources from this episode: Write Your Way Through It starts on January 21st! Come join us at Rythmia in January! Michelle's websiteMichelle's book, Don't Snooze Your Dreams Book recommendations: I love a good personal development book, and you do too, right? I've compiled a list of book recommendations, as mentioned in past episodes. Check out these amazing book recommendations here. Happy reading!   MSN is supported by: We love the sponsors that make our show possible! You can always find all the special deals and codes for all our current sponsors on our website: andreaowen.com/sponsors/ http://andreaowen.com/podcast/710 Learn more about your ad choices. Visit podcastchoices.com/adchoices

Didn't see that coming.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Clinical Advances and Unanswered Questions in Narcolepsy," Lindsay McCullough, MD, discusses how clinical understanding of narcolepsy has evolved, where major diagnostic and treatment advances have occurred, and where important gaps remain. McCullough, assistant professor of medicine and associate program director for the sleep medicine fellowship at Rush University, reflects on progress in defining narcolepsy subtypes, the growing role of orexin biology, and how recent research in 2025 has reshaped conversations around disease-modifying approaches. The discussion also explores emerging links between sleep disorders and neurodegenerative disease, common misconceptions that continue to delay diagnosis, and how clinician education can improve recognition, safety, and long-term management of patients with narcolepsy. Looking for more Sleep Disorder discussion? Check out the NeurologyLive® Sleep Disorder clinical focus page. Episode Breakdown: 1:05 – Advances and remaining gaps in the clinical understanding of narcolepsy 2:30 – How narcolepsy care and research meaningfully evolved throughout 2025 4:50 – Sleep disorders, neurodegeneration, and what clinicians should watch for 6:50 – Neurology News Minute 8:50 – Persistent myths that delay diagnosis and affect clinical decision-making 12:30 – How lived experience shapes holistic, patient-centered narcolepsy care The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: FDA Approves Inebilizumab for AChR- and MuSK-Positive Generalized Myasthenia Gravis FDA Clears Pivotal Phase 3 PREVAiLS Study of Pridopidine in Early, Rapidly Progressive ALS Tolebrutinib Falls Short in Phase 3 PERSEUS Study, Forcing Decision to Redact Regulatory Submission Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

See how top sleep specialists turn evidence into action with real-world cases that reveal smarter, patient-centered treatment strategies. Credit available for this activity expires: 12/22/26 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/case-review-narcolepsy-and-idiopathic-hypersomnia-2025a1000zqa?ecd=bdc_podcast_libsyn_mscpedu

We've gathered the NaPS lab to answer all your fascinating questions on all things sleep! A perfect bitesize episode to get stuck into the marvellous world of sleep. 1. How does sleep deprivation affect mental health? - Answered by Martha WawrzutaBunney, B. G. , Bunney, W. E. (2013). Mechanisms of Rapid Antidepressant Effects of Sleep Deprivation Therapy: Clock Genes and Circadian Rhythms. Biological PsychiatryFang, H., Tu, S., Sheng, J., Shao, A. (2018). Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment. Journal of Cellular and Molecular Medicine2. What is narcolepsy? - Answered by Kyrillos MeshrekyLeschziner G., Narcolepsy: a clinical review, Practical Neurology 2014;14:323-3313. Does the full moon affect sleep? - Answered by Al Saqib MajumderCasiraghi, L. et al. (2021). Moonstruck sleep: Synchronization of human sleep with the moon cycle under field conditions. Chaput, J. P. et al. (2016). Are Children Like Werewolves? Full Moon and Its Association with Sleep and Activity Behaviors in an International Sample of Children. Sleep Medicine4. How does a smart watch track sleep? - Answered by Yan Wang5. What is orthosomnia? - Answered by Sophie Smith Baron, K.G., et al. (2017) Orthosomnia: Are some patients taking the quantified self too far? J Clin Sleep Med6. What is sleep regression and how long does it last? - Answered by Mo AbdellahiWeinraub, M. et al. (2012). Patterns of developmental change in infants' nighttime sleep awakenings from 6 through 36 months of age. Developmental PsychologyBruni O. et al. (2014) Longitudinal study of sleep behavior in normal infants during the first year of life. J Clin Sleep Med7. Does Magnesium Citrate help you sleep? - Answered by Dulni PeramunugamageMagnesium for sleep, Sleep Foundation, 20258. Does dark chocolate help you sleep? - Answered by Martha Nguyen Abdoli, E. et al. (2024). A clinical trial of the effects of cocoa rich chocolate on depression and sleep quality in menopausal women. Scientific reports,Garbarino, S., Garbarino, E., & Lanteri, P. (2022). Circadian Rhythm, Mood, and Temporal Patterns of Eating Chocolate: A Scoping Review of Physiology, Findings, and Future Directions. NutrientsMusic by Sergio Prosvirini from PixabayCheck out our NaPS website to find out more about the podcast, our research and events. This recording is the property of the Sleep Science Podcast and not for resale.

Thank you Chris Abraham, OMS III, for developing this podcast! Thank you Gentry Ensign, OMS IV for being a great sidekick.This podcast has a high yield section focused on questions that relate to concordance in schizophrenia and how to consider questions about narcolepsy. It then dives into conversation about how Chris managed having TWINS in the middle of his rotation (and Narcolepsy). The podcast became somewhat philosophical in terms of how we choose to be physicians and the balance in life we make. We enjoyed our discussion and hope you do too!Thank you to the physicians that have blazed the podcast pathway over the last half decade. Thank you to the new students that carry the torch! Thank you to the immortal Jordan Turner for creating the perfect bumper music! Most of all, thank you to everybody that listens in and learns with us.

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Mood, Behavior, and Quality of Life in Parkinson Disease," Sneha Mantri, MD, MS, Chief Medical Officer at the Parkinson's Foundation, discusses how mood and behavioral symptoms shape the lived experience of people with Parkinson disease across the disease course. Mantri, a practicing movement disorders specialist with extensive training and experience, explains why depression and anxiety often precede motor symptoms, how these issues evolve with cognitive change, and why they remain key drivers of quality of life. Mantri reviews commonly used screening tools – including the PHQ-2/9, Geriatric Depression Scale, GAD-7, and emerging measures like the HOPE questionnaire – emphasizing their role in opening deeper clinical conversations. She also highlights Parkinson's Foundation initiatives that support both clinicians and patients, from PD Health at Home programming to team-based care models. The conversation concludes with ongoing challenges, including cultural barriers to mental health care, access limitations, and the continued need for true mental health parity in Parkinson disease management. Looking for more Movement disorder discussion? Check out the NeurologyLive® Movement disorder clinical focus page. Episode Breakdown: 1:10 – How mood and behavior symptoms shape Parkinson disease quality of life 5:30 – How conversations about mental health in Parkinson disease have evolved 9:25 – Screening tools and practical assessment strategies for mood and anxiety 13:40 – Neurology News Minute 15:50 – Foundation and community initiatives supporting mood and behavior care 19:50 – Remaining gaps, cultural barriers, and mental health parity challenges The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: CTAD Presentation Lays Insights Into Disappointing Phase 3 EVOKE Trial of GLP-1 Semaglutide in Alzheimer Disease Gene Therapy ETX101 Demonstrates Significant Effects on Seizure Reduction, Neurodevelopmental Outcomes in POLARIS Phase 1/2 Program FDA Accepts NDA for Low-Sodium Oxybate TRN-257 in Narcolepsy and Idiopathic Hypersomnia Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

Empower your conversations with patients living with narcolepsy. Learn best clinical practices for identifying, discussing, and managing cardiovascular comorbidities to improve long-term outcomes. Credit available for this activity expires: 12/04/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/expert-conversations-narcolepsy-improving-sleep-quality-2025a1000xq4?ecd=bdc_podcast_libsyn_mscpedu

Join this concise CME program, designed to deliver practical guidance to improve cardiovascular safety and symptom management in narcolepsy and idiopathic hypersomnia (IH). Credit available for this activity expires: 11/24/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/cardiovascular-safety-and-symptom-management-narcolepsy-and-2025a1000w9x?ecd=bdc_podcast_libsyn_mscpedu

Explore key symptoms and updated management of narcolepsy and idiopathic hypersomnia in this expert CME. Credit available for this activity expires: 11/20/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/narcolepsy-and-idiopathic-hypersomnia-24-hour-conditions-2025a1000vzp?ecd=bdc_podcast_libsyn_mscpedu

Send us a textThis Week We Need 2 Talk Stumble, Narcolepsy, Desiree's Darlings, Squid Game Challenge, Maxton Hall, Being Eddie Murphy, Pluribus, Selling the OC, BravoCon, A Merry Little Ex-Mas, Jonas Brothers Xmas Movie, The Beast in Me, Malice, Mormon Wives, Olivia Dean, Wedding Attire, and SO MUCH MORE 

The orexin receptor agonists are coming. After years of managing narcolepsy with stimulants, sodium oxybate, and wake-promoting agents, we soon will have medications that target the root cause of the disorder: the loss of orexin signaling. These new drugs—developed by Takeda, Alkermes, and Centessa—aren't just incremental improvements. They represent a genuine shift in how we understand and treat hypersomnolence disorders. In this episode, we will:Define what orexin is and why losing it destabilizes wakefulness, REM boundaries, muscle tone, and cognitionLearn how orexin agonists work—not as stimulants, but as replacement therapy for a missing neurotransmitterFind out why OX2R is the key receptor, and how selective agonists restore stable wakefulness, reduce cataplexy, and normalize attentionReview the available clinical data from the new wave of programs: oveporexton (Takeda), alixorexton (Alkermes), and ORX750 (Centessa)See what makes these drugs different from modafinil, amphetamines, solriamfetol, and oxybate therapiesLearn why Phase 1, Phase 2, and Phase 3 trials matter—with quick insights on how these drugs reached such strong resultsConsider safety and side effects, including what Hy's Law means and why regulators watch liver signals so closelyLook ahead to what these medications may mean for NT1, NT2, IH, and other hypersomnolence disorders in the coming yearsSpeculate why this class represents one of the most exciting moments in modern sleep medicineProduced by: Maeve WinterMore Twitter: @drchriswinter IG: @drchriwinter Threads: @drchriswinter Bluesky: @drchriswinter The Sleep Solution and The Rested Child Thanks for listening and sleep well!

Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comIn this fascinating episode, Dr. Gabrielle Lyon talks with neuroscientist Dr. Ben Rein, PhD (author of Why Brains Need Friends), about the science of social connection, emotion, and cognitive health. Dr. Rein, an expert in neurobiology and psychedelic research, reveals the cutting-edge studies that explain why loneliness is as damaging as smoking and how our digital world is affecting our brain's ability to connect.They discuss the neurochemistry of love, the controversial use of MDMA in therapy, and whether AI can ever truly replace human intimacy. This conversation provides an essential look at the biological drivers of happiness, performance, and long-term brain health.Chapter Markers:0:00 - MDMA (Molly): The History & Therapeutic Benefits 5:59 - The Legal Status of MDMA for PTSD 6:44 - The Safety and Effectiveness of MDMA in Clinical Trials 8:29 - PTSD (The Amygdala Alarm) 9:41 - How MDMA Soothes the Amygdala to Access Memory 11:42 - Is There an Alternative to MDMA? (Ketamine's Mechanism) 13:16 - Ketamine and Neuroplasticity for Depression 15:48 - Botox and Empathy: 18:12 - The Problem of Volume: How Screens Depersonalize Interaction 19:48 - The Virtual Disengagement Hypothesis Explained 25:00 - Defining Cognitive and Emotional Empathy 29:43 - MDMA's Link to Serotonin & Social Reward 31:04 - Do SSRIs Have Pro-Social Effects? 36:10 - The Science of Likability and "Easy to Read" Faces 40:10 - Top 3 Ways to Be More Likable49:49 - The Likability Gap: Why You Underestimate How Well-Liked You Are 56:59 - The Neurobiology of Oxytocin, Dopamine, and Serotonin1:09:23 - The Goldilocks Zone of Empathy 1:15:58 - Narcolepsy 1:18:16 - Alcohol: Why the Neurotoxin is Bad for Brain Health 1:21:47 - Exercise and Neurogenesis1:22:27 - Sex, Orgasm, and Oxytocin Release 1:25:06 - Oxytocin During Childbirth Who is Ben Rein:Dr. Ben Rein is an award-winning neuroscientist and Chief Science Officer of the Mind Science Foundation, where he supports early-career researchers in neuroscience. He earned his PhD from SUNY Buffalo and completed postdoctoral training at Stanford University, publishing over 20 peer-reviewed papers on autism, empathy, MDMA, and digital behavior. Recognized by the NIH, the Society for Neuroscience, and Sigma Xi, he also serves as a scientific advisor to more than 20 organizations. With over one million followers and 75 million video views, Dr. Rein is celebrated for making neuroscience accessible to the public and has been featured by outlets such as Good Morning America, ABC News, and PopularMechanics.Thank you to our sponsors:BodyHealth: Use code LYON20 to get 20% off your first order https://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/BON CHARGE Holiday Sale https://boncharge.com for 25% off Pique 20% off for life: https://Piquelife.com/DRLYONFind Ben Rein at: Website: https://www.benrein.com/Instagram: https://www.instagram.com/dr.benrein/#TikTok: https://www.tiktok.com/@dr.benrein?lang=enFacebook:

What happens when a lifelong dream collides with an unexpected diagnosis? For David Suarez, the path seemed clear from the age of six: become a cardiovascular surgeon and heal broken hearts. But when David was fast-tracked into Brown University's prestigious medical school, a sidelining diagnosis and an aha from God showed him that there was more than one way to fix a broken heart. A shower of surrender showed David an entirely new way to see God and deal with his narcolepsy diagnosis. And he found a natural antidote in sharing Jesus with others that led David down an entirely new career path.  David is now a high school Bible teacher as well as published apologist. See how God guides David from one passionate career choice to another, and how he is now fixing broken hearts.Some of David's Books:David's Book, Worldview Review: A Guide to Worldview Formation, Christian Apologetics, Comparative Religion, and Evaluating Competing Belief SystemsDavid's Book, The Death of Allah, 10 paradoxes that dismantle Islamist theismWhat Should a Muslim Believe? a field guide for ChristiansThe Sleepy Seminarian, apologetics questions and answers by DavidHelpful Links:Reformed University FellowshipNarcolepsy or HypersomniaLet us know what you thought of the show!Follow One80 on Apple Podcasts, Spotify, or our website.Never miss a One80. Join our email list. Follow us on Instagram.Share One80, here's how!OneWay Ministries

Aubrey Masango speaks to Dr Angelique Coetzee, General Practitioner, to discuss narcolepsy, the the causes, symptoms, treatment options. She further explains the difference types of narcolepsies. Tags: 702, Aubrey Masango show, Aubrey Masango, Bra Aubrey, Dr Angelique Coetzee, Narcolepsy, sleep disorder, Neurological disorder The Aubrey Masango Show is presented by late night radio broadcaster Aubrey Masango. Aubrey hosts in-depth interviews on controversial political issues and chats to experts offering life advice and guidance in areas of psychology, personal finance and more. All Aubrey’s interviews are podcasted for you to catch-up and listen. Thank you for listening to this podcast from The Aubrey Masango Show. Listen live on weekdays between 20:00 and 24:00 (SA Time) to The Aubrey Masango Show broadcast on 702 https://buff.ly/gk3y0Kj and on CapeTalk between 20:00 and 21:00 (SA Time) https://buff.ly/NnFM3Nk Find out more about the show here https://buff.ly/lzyKCv0 and get all the catch-up podcasts https://buff.ly/rT6znsn Subscribe to the 702 and CapeTalk Daily and Weekly Newsletters https://buff.ly/v5mfet Follow us on social media: 702 on Facebook: https://www.facebook.com/TalkRadio702 702 on TikTok: https://www.tiktok.com/@talkradio702 702 on Instagram: https://www.instagram.com/talkradio702/ 702 on X: https://x.com/Radio702 702 on YouTube: https://www.youtube.com/@radio702 CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.

REM Sleep, Clock Curses, and Alien Heat Lightning Vote Box of Oddities For People's Choice Award Here! Live Show Info And Tickets Here! In this listener-powered episode of The Box of Oddities, JG and Kat crack open the inbox and out pour... auditory hallucinations, ghost clocks, spontaneous astral projection, and the shocking truth about “heat lightning.” (Spoiler: it's probably aliens.) First, a listener shares how her dreams are so vivid and reality-bending due to Narcolepsy that she's genuinely not sure which world is real—relatable, terrifying, and yes, somehow still funny. Then, a cursed wall clock starts ticking every time someone dies. No batteries. No mercy. Just 12 minutes of tick-tock you're next. Meanwhile, someone else swears that a strange sky phenomenon isn't just distant thunder—it's the government covering up UFO joyrides. (Can't argue with that logic.) You'll also hear about a haunted hallway birth involving Richard Simmons, dolphin-whale linguistics, astral projection lessons, and what happens when massage therapists listen to BoO during bodywork sessions (spoiler: they cry, and so do you). Whether it's clock-based death omens or the weirdly uplifting side of functional neurological disorders, this Inbox delivers what your brain craves: weird, real, and unreal tales from the wonderfully odd corners of the BoO family. Listen now... or risk becoming the sixth tick of the clock. Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 53 - My Life with Narcolepsy and Cataplexy - Solomon Briggs, a sleep advocate living with narcolepsy and cataplexy shares his personal journey of discovering his condition. Disclaimer: Please note that all information and content on the UK Health Radio Network, all its radio broadcasts and podcasts are provided by the authors, producers, presenters and companies themselves and is only intended as additional information to your general knowledge. As a service to our listeners/readers our programs/content are for general information and entertainment only.  The UK Health Radio Network does not recommend, endorse, or object to the views, products or topics expressed or discussed by show hosts or their guests, authors and interviewees.  We suggest you always consult with your own professional – personal, medical, financial or legal advisor. So please do not delay or disregard any professional – personal, medical, financial or legal advice received due to something you have heard or read on the UK Health Radio Network.

What are some of the most common sleep disorders? We go to Med School to find out whether owning a dog can reduce your risk of dementia. And in our Quick Consult, should you be scared if you’ve put off your health checks for far too long? In this episode, Dr Kathleen Maddison discusses the most common causes of insomnia in women and whether our hormones play a role. We also talk about sleepwalking, narcolepsy and sleep apnoea and find out how much sleep we really need, And, what is the “3P model” when it comes to insomnia and do non-drug treatments actually work? Plus, why do we wake up at 3:00am and how can we make it stop? THE END BITS All your health information is in the Well Hub. For more information on sleep including a list of providers of CBTi, Dr Kathleen Maddison recommends: Sleep Health Foundation Sleep Central GET IN TOUCH Sign up to the Well Newsletter to receive your weekly dose of trusted health expertise without the medical jargon. Ask a question of our experts or share your story, feedback, or dilemma - you can send it anonymously here, email here or leave us a voice note here. Ask The Doc: Ask us a question in The Waiting Room. Follow us on Instagram and Tiktok. Support independent women’s media by becoming a Mamamia subscriber Want $10 + a free month of Mamamia? We've got you! We're cooking up something exciting and need your brilliant opinions to help us make even better content. It's just 20 minutes of your time, and you'll get a $10 e-gift card + a 1 month Mamamia subscription (or gift it to someone if you're already a subscriber). Do the survey HERE. T&Cs here CREDITS Hosts: Claire Murphy and Dr Mariam Guests: Dr Kathleen Maddison Senior Producers: Claire Murphy and Sasha Tannock Audio Producer: Scott Stronach Video Producer: Julian Rosario Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures.Information discussed in Well. is for education purposes only and is not intended to provide professional medical advice. Listeners should seek their own medical advice, specific to their circumstances, from their treating doctor or health care professional.Support the show: https://www.mamamia.com.au/mplus/See omnystudio.com/listener for privacy information.

Get ready for a snooze-tastic episode, darlings! Join Amy Phillips as she delves into the fascinating world of sleep with the incredible Dr. Sam Kashani, an MD sleep medicine expert. Discover Dr. Kashani's unique journey from film school to sleep medicine, including his work on major films like 'Shutter Island'. Learn vital insights into common sleep disorders, the power of cognitive behavioral therapy for insomnia (CBTI), the mysteries of REM sleep, and the impact of cannabis and alcohol on sleep quality. Whether you're curious about sleep paralysis, idiopathic hypersomnia, or the best sleep aids, this episode has got you covered. Don't miss out on this enlightening conversation that's sure to make you rethink your bedtime routine!DR. SAM KASHANI CONTACT:https://www.linkedin.com/in/samkashanimdhttps://www.instagram.com/samkashanimd?igsh=NTc4MTIwNjQ2YQ%3D%3DFor more Drama, Darling, and exclusive content, subscribe to: http://Patreon.com/dramadarling Follow Drama, Darling on Instagram: https://www.instagram.com/dramadarlingshow/  Email Drama, Darling with YOUR comments, questions and drama:  DramaDarlingz@gmail.com Follow Amy Phillips on Instagram: https://www.instagram.com/dramadarlingshow/  Function Health, to learn more and get started, visit:www.functionhealth.com/DDGet 20% OFF Honeylove by going to: https://www.honeylove.com/DRAMAPromo Code: DRAMA

BIO:Julie Flygare, JD, serves as President & CEO of Project Sleep. Flygare is an internationally recognized patient-perspective leader, an accomplished advocate, and the award-winning author of Wide Awake and Dreaming: A Memoir of Narcolepsy. In March 2022, she delivered the TEDx Talk, “What Can You Learn from a Professional Dreamer?” In 2024, Flygare was awarded the Sleep Research Society's Public Service Award for significantly advancing the mission of the SRS through advocacy and public policy efforts. SHOWNOTES:

Falling asleep is easy—until it becomes the hardest part of your day. Recorded live in Toronto, this episode dives into the unpredictable world of narcolepsy type 1 with Heather, a traditional Chinese medicine practitioner living with both narcolepsy and cataplexy. From sleep-deprived misdiagnoses to lucid hallucinations and arms that give out mid-laugh, Heather walks us through the reality behind the disorder's misunderstood pop culture image. She opens up about losing her spontaneity, finding community, and redefining rest, all while navigating a healthcare system still catching up. It's funny, eye-opening, and more than a little dreamlike.

Falling asleep is easy—until it becomes the hardest part of your day. Recorded live in Toronto, this episode dives into the unpredictable world of narcolepsy type 1 with Heather, a traditional Chinese medicine practitioner living with both narcolepsy and cataplexy. From sleep-deprived misdiagnoses to lucid hallucinations and arms that give out mid-laugh, Heather walks us through the reality behind the disorder's misunderstood pop culture image. She opens up about losing her spontaneity, finding community, and redefining rest, all while navigating a healthcare system still catching up. It's funny, eye-opening, and more than a little dreamlike.

Watch an insightful symposium exploring narcolepsy comorbidities and their significant impact on effective disease management Credit available for this activity expires: 6/30/25 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/med-feud-challenge-narcolepsy-winning-formula-personalizing-2025a1000h7j?ecd=bdc_podcast_libsyn_mscpedu

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Narcolepsy is a chronic sleep disorder characterized by overwhelming daytime drowsiness and sudden attacks of sleep. People with narcolepsy often find it difficult to stay awake for long periods of time, regardless of the circumstances. Narcolepsy can cause serious disruptions in your daily routine.  Our guest today is Lindsey who will discuss her life with narcolepsy.   ​ Lindsey grew up in Charlotte NC and is currently residing nearby in Belmont, NC with her husband and dog. She was diagnosed in May of 2019 after dealing with symptoms since childhood. She was previously misdiagnosed and had doctors dismiss her sleepiness for being a normal teenager or college student. She continued to press doctors for answers and finally received a diagnosis and began treatment less than a year ago. She is now trying to speak out an advocate so that others do not have to have the same long path to diagnosis she did. 

Dr. Saima Khan is a physician with over 27 years of experience and a deeply personal story of resilience and transformation. Diagnosed with narcolepsy in 2016 after stepping away from medicine due to chronic fatigue and excessive sleepiness, she found herself navigating the healthcare system not as a doctor but as a patient. When conventional treatments failed, she took her health into her own hands, uncovering and addressing multiple causes of brain inflammation including mold illness, Lyme disease and coinfections, chronic SIBO, mast cell activation, autoimmunity and much more. Dr. Saima holds a Doctor of Medicine from Aga Khan University, known as the "Harvard of Pakistan." She completed her Pediatric Residency at Children's Hospital of Michigan, and fellowship in Medical Toxicology at Wayne State University. She is board-certified in Pediatrics and certified in Functional Medicine from the Institute for Functional Medicine. She also has advanced training in chronic illnesses like Lyme and coinfections, and mold. As the founder of Rebalance Family Health, a virtual practice based in Florida, Dr. Saima specializes in helping adults and children with complex illnesses with a focus on lyme and coinfections, mold illness, autoimmunity and inflammatory brain disorders. Her mission is to alleviate suffering by uncovering root causes, connecting the dots, and empowering patients to live vibrant, healthy lives. Some of the topics we discussed were: Dr. Khan's background in toxicology Where Dr. Khan found her information on toxins Dr. Khan's next steps to address the root cause of her narcolepsy Mold and microtoxin illness How Dr. Khan's narcolepsy symptoms have vastly improved What the last missing piece was for Dr. Kahn in recovering from her narcolepsy And more!Learn more about me or schedule a FREE coaching call:https://www.joyfulsuccessliving.com/ Join the Voices of Women Physicians Facebook Group: https://www.facebook.com/groups/190596326343825/  Connect with Dr. Khan: Website:www.rebalancefamilyhealth.com Instagram:@drsaimakhanmd 

Dr. Saima Khan is a physician with over 27 years of experience and a deeply personal story of resilience and transformation. Diagnosed with narcolepsy in 2016 after stepping away from medicine due to chronic fatigue and excessive sleepiness, she found herself navigating the healthcare system not as a doctor but as a patient. When conventional treatments failed, she took her health into her own hands, uncovering and addressing multiple causes of brain inflammation including mold illness, Lyme disease and coinfections, chronic SIBO, mast cell activation, autoimmunity and much more.Dr. Saima holds a Doctor of Medicine from Aga Khan University, known as the "Harvard of Pakistan." She completed her Pediatric Residency at Children's Hospital of Michigan, and fellowship in Medical Toxicology at Wayne State University. She is board-certified in Pediatrics and certified in Functional Medicine from the Institute for Functional Medicine. She also has advanced training in chronic illnesses like Lyme and coinfections, and mold.As the founder of Rebalance Family Health, a virtual practice based in Florida, Dr. Saima specializes in helping adults and children with complex illnesses with a focus on lyme and coinfections, mold illness, autoimmunity and inflammatory brain disorders. Her mission is to alleviate suffering by uncovering root causes, connecting the dots, and empowering patients to live vibrant, healthy lives.Some of the topics we discussed were:How Dr. Khan's journey into functional and integrative medicine began from her narcolepsyDr. Khan's first steps for finding a solution to her narcolepsy Why stimulants and conventional medicine designed to keep you awake can only help so much with narcolepsyNarcolepsy being an autoimmune condition How reducing inflammation through Dr. Khan's diet reduced her narcolepsy symptomsWhat intervention Dr. Khan says helped her the most if she had to choose only oneWhy detoxifying the body and environment is like fixing a plumbing problemHow detoxifying reduces narcolepsy symptomsAnd more!Learn more about me or schedule a FREE coaching call:https://www.joyfulsuccessliving.com/Join the Voices of Women Physicians Facebook Group:https://www.facebook.com/groups/190596326343825/Connect with Dr. Khan:Website:www.rebalancefamilyhealth.comInstagram:@drsaimakhanmd

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This is episode 2 of a 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology and founder of the Center for Human Sleep Science at the University of California, Berkeley. We discuss basic and advanced tools for improving sleep and explain how sleep quality is affected by temperature, light and dark, caffeine, alcohol, cannabis, nutrition, meal timing, and different medications.  Dr. Walker also provides strategies for coping with a poor night of sleep, wind-down routines, technology in the bedroom, insomnia, visualizations, and building sleep “confidence.”  We also discuss the current status of sleep research for developing advanced techniques to optimize sleep.  This episode provides numerous zero-cost behavioral protocols for improving sleep quality and restorative power, which can benefit daytime mood, energy, performance, and overall health.  The next episode in this special series explores napping, caffeine, and additional protocols to improve sleep. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman WHOOP: https://join.whoop.com/huberman Waking Up: https://wakingup.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Improving Sleep (00:01:16) Sponsors: Helix Sleep, WHOOP & Waking Up (00:05:30) Basics of Sleep Hygiene, Regularity, Dark & Light (00:12:05) Light, Day & Night; Cortisol, Insomnia (00:18:45) Temperature; “Walk It Out”; Alcohol & Caffeine (00:26:05) Sleep Association, Bed vs. Sofa (00:29:43) Tool: Falling Asleep; Meditation, Breathing (00:35:23) Sponsor: AG1 (00:36:37) Alcohol & Sleep Disruption (00:40:01) Food & Sleep, Carbs, Melatonin (00:49:25) Caffeine; Afternoon Coffee, Nighttime Waking (00:55:52) Caffeine Metabolism & Sleep, Individual Variation (01:01:19) Sponsor: InsideTracker (01:02:04) Cannabis: THC vs. CBD, REM Sleep, Withdrawal (01:12:03) Sleep Hygiene Basics (01:16:08) Tool: Poor Sleep Compensation, “Do Nothing” (01:20:23) Tool: Sleep Deprivation & Exercise (01:24:11) Insomnia Intervention & Bedtime Rescheduling, Sleep Confidence (01:32:58) Wind-Down Routine; Mental Walk; Clocks & Phones (01:41:29) Advanced Sleep Optimization, Electric Manipulation (01:50:07) Temperature Manipulation, Elderly, Insomnia (01:58:57) Tool: Warm Bath Effect & Sleep, Sauna (02:04:36) Acoustic Stimulation, White Noise, Pink Noise (02:13:30) Rocking & Sleep, Body Position (02:24:17) Enhance REM Sleep & Temperature; Sleep Medications (02:28:35) Pharmacology, DORAs & REM Sleep; Narcolepsy & Insomnia (02:34:12) Acetylcholine, Serotonin, Peptides; Balance (02:40:45) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer