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TWiV reviews a facility accident that killed monkeys, new bird blu genotype found in Nevada dairy cattle, Argentina plans to leave WHO, yellow fever on the rise, dynamics of HPV infections in women, and Epstein-Barr virus protein targets B cell receptor for degradation. Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Accident kills monkeys at SC research supply facility (Science) D1.1 Genotype in Dairy Cattle in Nevada (APHIS) Argentina to leave WHO (CIDRAP) Yellow fever on the rise (CIDRAP) HPV dynamics in women (PLoS Biol) EBV protein degrades B cell receptor (PNAS) Letters read on TWiV 1193 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences (one, two) Alan – A little adventure game Vincent – The Staggering Success of Vaccines Listener Picks John – Percy Lavon Julian Debi – Don't Look Up Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune cells in the human body (PNAS) Letters read on Immune 73 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Marburg virus disease outbreak in Equatorial Guinea (WHO) •Wild-type poliovirus type 3 from laboratory (Eurosurveillance) •Extinct SARS-CoV-2 VOC in white-tailed deer (PNAS) •Letters read on TWiV 985 •Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz Project: Vibraphone: Lionel Hampton/Gary Burton/Cal Jader. Lionel Hampton: Signature album: The Classics Album Collection, Signature song: Flying Home. Gary Burton: Signature album: A Genuine Tong Funeral. Signature song: General Mojo's Well Laid Plan. Cal Jader: Signature album: Latin Kick. Signature song: Soul Sauce (Wachi Wara). Milt Jackson (a member of the Modern Jazz Quartet). Signature song: Ice Skating in Central Park. Rich – The American Phage Group: Founders of Molecular Biology by William C. Summers Vincent – DJ Miss Monique aka Olesia Arkusha Listener Pick Megan – The Day The Music Stopped: How a 1942 recording ban changed America forever and The Weather Channel presents the best of smooth Jazz Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
TWiV explains the recent meeting of the National Science Advisory Board for Biosecurity (NSABB) where stricter guidelines for research involving human, animal, and plant pathogens were considered, and how the consumption of viruses by small protists returns energy to food chains. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •NSABB proposed oversight framework (pdf) •Stricter US guidelines for research (Nature) •Information on NSABB (NIH) •Consumption of viruses by protists (PNAS) •Letters read on TWiV 981 •Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz Project: Trombone: Steve Turre/Conrad Herwig; Steve Turre; Curtis Fuller; J.J. Johnson and Kai Winding. Steve Turre: Signature album: Sanctified Shells. Signature song: Sanctified Shells. Conrad Herwig. Signature album: A Jones For Bones Tones. Signature song: Slide's Routine; Curtis Fuller: Signature album: BLUES ette. Signature song: Bluesette. J.J. Johnson (with Kai Winding). Signature album: The Great Kai and J.J. : Signature song: Monk's Blues. Kathy – Measles virus ‘cooperates' with itself to cause fatal encephalitis. Primary research article: Shirogane et al. Rich – Firm hatches plan to bring back dodo (Colossal Biosciences – Dodo) Alan – Mt. Washington Observatory webcam Vincent – Ask the Experts Listener Picks Roberto – The Contagion of Liberty: The Politics of Smallpox in the American Revolution Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox in MA (ProMed Mail) Possible monkeypox in NYC (NY Times) Occupational monkeypox, Wisconsin (Emerg Inf Dis) SARS-CoV-2 in feces (Nature) IFN autoantibodies and severe COVID-19 (PNAS) Letters read on TWiV 902 Timestamps by Jolene. Thanks! Weekly Picks Dickson – How to grow food on the moon Brianne – APod May 16: Milky Way over French Alp Hoodoos Kathy – Covid Nationwide data visualization Rich – NIH All of Us Research Program Vincent – Physicians Spreading Misinformation on Social Media — Do Right and Wrong Answers Still Exist in Medicine? Listener Pick Lisa – E.H. Danner Museum of Telephony Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes towards public communication. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Viral brain entry by transcytosis across endothelial cells (mBio) Scientists attitudes towards public communication (PNAS) Letters read on TWiV 746 Timestamps by Jolene. Thanks! Weekly Picks Dickson – NASA ingenuity helicopter ride Brianne – Vaccine Efficacy Animation Kathy – Airglow over the Azores Vincent – Gisaid Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes towards public communication. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Viral brain entry by transcytosis across endothelial cells (mBio) Scientists attitudes towards public communication (PNAS) Letters read on TWiV 746 Timestamps by Jolene. Thanks! Weekly Picks Dickson – NASA ingenuity helicopter ride Brianne – Vaccine Efficacy Animation Kathy – Airglow over the Azores Vincent – Gisaid Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NIDO 2021 Symposium ASV hosts free COVID-19 Vaccine Education Town Halls (register here) Research position in Spindler laboratory Attenuation of poliovirus by codon deoptimization (Science) Rescue of codon-deoptimized RSV by large deletions (PNAS) Letters read on TWiV 740 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Let us now praise tiny ants Brianne – Small-school science Rich – Smallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court Kathy – The Transcontinental Burrito Tunnel Vincent – Glass music by Robert Tiso Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NIDO 2021 Symposium ASV hosts free COVID-19 Vaccine Education Town Halls (register here) Research position in Spindler laboratory Attenuation of poliovirus by codon deoptimization (Science) Rescue of codon-deoptimized RSV by large deletions (PNAS) Letters read on TWiV 740 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Let us now praise tiny ants Brianne – Small-school science Rich – Smallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court Kathy – The Transcontinental Burrito Tunnel Vincent – Glass music by Robert Tiso Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Daniel’s COVID-19 testing strategy calculator (and medRxiv preprint) US COVID-19 mortality rates (JAMA) Final remdesivir report (NEJM) Hydroxychloroquine for COVID-19 (NEJM) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders Smell and taste changes as early pandemic indicators (Nat Comm) Vascular disease and thrombosis in SARS-CoV-2 infected macaques (Cell) SADS-CoV can infect human airway cells (PNAS) Letters read on TWiV 673 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – The Age of Nature Brianne – Virologist, Immunologist, Science Communicator pins and Virus Earrings Alan – Sharks, Squalene, and a SARS-CoV-2 Vaccine Rich – 6th Annual Science Mill Benefit Vincent – The Evolution of Infectious Disease by Paul Ewald Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Daniel’s COVID-19 testing strategy calculator (and medRxiv preprint) US COVID-19 mortality rates (JAMA) Final remdesivir report (NEJM) Hydroxychloroquine for COVID-19 (NEJM) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders Smell and taste changes as early pandemic indicators (Nat Comm) Vascular disease and thrombosis in SARS-CoV-2 infected macaques (Cell) SADS-CoV can infect human airway cells (PNAS) Letters read on TWiV 673 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – The Age of Nature Brianne – Virologist, Immunologist, Science Communicator pins and Virus Earrings Alan – Sharks, Squalene, and a SARS-CoV-2 Vaccine Rich – 6th Annual Science Mill Benefit Vincent – The Evolution of Infectious Disease by Paul Ewald Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
The TWiM team explains how breathing can transmit SARS-CoV-2, and how lack of breathing leads to loss of mitochondria in a multicellular parasitic animal. Become a patron of TWiM. Links for this episode: Reducing transmission of SARS-CoV-2 (Science) Why social distancing is important (NY Times) Parasite without mitochondria (PNAS) Letters read on TWiM 218 Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv
The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Role of B cells in Marek's disease pathogenesis (PNAS) In ovo vaccination (YouTube) First chickens lacking B cells (PNAS) Letters read on Immune 16 Time stamps by Jolene. Thanks! Weekly Science Picks Steph - 7 Days Out Cindy - Watson PBS documentary and Cold Spring Harbor Laboratory response Vincent - Dads can donate mitochondrial DNA and Chicken puns
The TWiM team reveals the oldest human plague from 4,900 years ago in Sweden, and engineering E. coli to become an endosymbiont in yeast, modeling the evolution of mitochondria. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM. Links for this episode Oldest human plague from 4,900 years ago (PNAS) Engineering yeast endosymbionts (PNAS) Letters read on TWiM 191 TWiM Listener survey Send your microbiology questions and comments (email or recorded audio) to "mailto:twim@microbe.tv">twim@microbe.tv
The TWiM people reveal that phages must cooperate to overcome CRISPR-Cas defenses, and the effect of the herbicide glyphosate on the gut microbiome of honey bees. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Links for this episode: Phages Cooperate to Overcome CRISPR-Cas Immunity (Cell) Glyphosate perturbs gut microbiota of honey bees (PNAS) Letters read on TWiM 187
The TWiV team reveal the origin of the poxvirus membrane, and how a retrovirus drove the development of the placenta of a lizard. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Support Microbe.tv Origin of poxvirus membrane (PNAS) Poxvirus movies: Movie S1, Movie S2, Movie S3, Movie S4, Movie S5 Lizard placenta from a retrovirus (PNAS) Letters read on TWiV 472 Weekly Science Picks Kathy - Google doodles Discoverer of photosynthesis Robert Koch Dickson - Nature Photography Winners Rich - The Raging Idiots Planet Song Alan - Zooborns Vincent - Glass Insects and Plants by Yuki Tsunoda Listener Picks Scott - Sagan Series Paul - SMBC Comics Trudy - If Scientists Wrote Christmas Songs Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode Truth Wins by Jonathan Yewdell (epub or mobi) Gabriel Victora awarded MacArthur Prize Forty Years of mRNA Splicing (CSH) 2017 Chemistry Nobel: Jacques Dubochet, Joachim Frank, Richard Henderson 2017 Physiology or Medicine Nobel: Jeffrey C. Hall, Michael Rosbash, Michael W. Young 2017 Nobel Prize in Chemistry (pdf) 2017 Nobel Prize in Physiology of Medicine (pdf) Jonathan Weiner on TWiEVO 19 RNA methylation modulates plant virus infectivity (PNAS) Letters read on TWiV 463 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv. This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Weekly Science Picks Kathy - When biospheres collide Dickson - Blame 10 rivers for ocean plastic Alan - Farming in The Netherlands Vincent - Meet the Microbiologist Listener Picks Jay - OmegaTau podcast Trudy - Arrowsmith by Sinclair Lewis Mark - iOS app Human Anatomy Atlas and Master in Business podcast Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiVoids discuss the March for Science, the GOF moratorium, and a classic virology paper on mapping the gene order for vesicular stomatitis virus. Become a patron of TWiV! Links for this episode ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart What is the Council on Microbial Sciences? Organization Chart FAQs Scientists' march is bad idea (NY Times) GOF moratorium lifted (Archived White House) VSV gene order (PNAS) VSV gene order later (PNAS) Letters read on TWiV 427 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - Good Omen miniseries (book) Kathy - How to cure earworms Dickson - Exoplanets orbits Vincent - Outbreak News Today Listener Pick Tom - The Smartest Protester Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team reviews a meta-analysis of clinical trial reports on using Tamiflu for influenza, and suggestions on how to rescue US biomedical research from its systemic flaws. Links for this episode World Malaria Day Review of oseltamivir clinical trials (Brit Med J) Effectiveness of Tamiflu questioned (NHS choices) Tamiflu campaign (Brit Med J) Rescuing US biomedical research (PNAS) Letters read on TWiV 282 Weekly Science Picks Alan - Northampton AirportVincent - Particle FeverKathy - Turn iPhone into microscopeRich - My favorite science gifs Listener Pick of the Week Nathan - The Ascent of Man (YouTube) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The complete TWiV team reviews evidence for sensing of herpesviral DNA in the nucleus by the cell protein IFI16. Links for this episode IFI16 is a nuclear pathogen sensor (Cell Host Micr) Nuclear IFI16 sensing of and antagonism by herpesvirus (PNAS) Acetylation regulates IFI16 location (PNAS) Letters read on TWiV 269 Weekly Science Picks Kathy - Female conveners and speakersAlan - SandgrainsRich - 2013 Lamborghini AventadorVincent - Happy Birthday Mac and 128K Mac teardownDickson - Farmdominion Listener Pick of the Week Peter - The Microscope and The Next Global KillerRichard - Glass viruses Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler The complete TWiV team reviews the controversial publication of the HeLa cell genome, a missing vial of Guanarito virus in a BSL-4 facility, and human infections with avian influenza H7N9 virus. Links for this episode: Containment plan for poliovirus (pdf, WHO) Post-eradication of polio Ocular tropism of respiratory viruses (MMBR) Rally for medical research HeLa genome sequence withdrawn (ScienceInsider) Immortal life sequel (Rebecca Skloot) HeLa genome sequence published, withdrawn (virology blog) Vial of Guanarito virus missing (ABC news) Human H7N9 infections (ProMedMail) WHO H7N9 updates China escalates H7N9 response (NY Times) Brian Kimble on H7N9 Compatibility of H9N2 and H1N1 genes (PNAS) Letters read on TWiV 227 Weekly Science Picks Kathy - NIAID YouTube videosAlan - Lego insectsRich - How to see the world in a grain of sandVincent - Vaccines, viruses, and the anti-vax movementDickson - Edinburgh Science Festival Listener Pick of the Week Stephen - Nature iOS appMehul - Voices for vaccines Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler The complete TWiV team reviews identification of the cell receptor for hepatitis B and D viruses, and the cell enzyme that cleaves the genome-linked protein from picornaviral RNA. Links for this episode: HBV and HDV cell receptor (eLIFE) Getting to grips with hepatitis (eLIFE) Sodium taurocholate Poliovirus hijacks DNA repair enzyme (PNAS) Letters read on TWiV 210 Weekly Science Picks Rich - Vendée GlobeDickson - Earth at nightAlan - Trophée Jules VerneKathy - Science cookiesVincent - Trilobite Glassworks Listener Pick of the Week Ken - Spanish flu pandemic model (teacher's guide)Jim - Santa Cruz Science Communication Program (also see SHERP) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter Vincent, Michael, and Elio discuss changing populations of Emiliania huxleyi and their viruses in the North and Black Seas. Right click to download TWiM #34 (50 MB .mp3, 69 minutes). Links for this episode: The protist wonderland (Microbe) Emiliania huxleyi home page DISCO in the North Sea (FEMS Microbiol Ecol) 7000 years of Emiliania huxleyi in the Black Sea (Science) Cheshire cat escape by Emiliania huxleyi (PNAS) Letters read on TWiM 34