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1. Operation Restore Justice Background: The document criticizes the Biden administration for allegedly ignoring child exploitation issues, contrasting it with the Trump administration's proactive stance. Operation Details: Led by Attorney General Pam Bondi and FBI Director Caspittel, Operation Restore Justice targeted child sex predators across the U.S. Results: Over five days, 205 individuals were arrested, and 115 children were rescued. Scope: Involved all 55 FBI field offices, the Department of Justice Child Exploitation Section, and U.S. Attorney's offices nationwide. Notable Arrests: Included a Minnesota state trooper, an Army reservist, and a former Metropolitan Police Department officer. Statements: Pam Bondi emphasized the seriousness of online child exploitation and the need for parents to monitor their children's online activities. FBI Director Caspittel highlighted the commitment to hunting down child predators. 2. Largest Fentanyl Seizure in U.S. History Background: The document discusses the Trump administration's efforts to combat drug trafficking, particularly fentanyl distribution by the Sinaloa cartel. Operation Details: The Attorney General announced the largest fentanyl seizure tied to the Sinaloa cartel, which operated in four major U.S. cities. Results: The DEA seized 11.5 kilos of fentanyl, including approximately 3 million fentanyl pills, along with other drugs, cash, and weapons. Notable Arrests: Included an illegal alien from Mexico leading the cartel's operations in the U.S. Statements: Pam Bondi and the Attorney General emphasized the dangers of fentanyl and the Trump administration's commitment to fighting drug cartels. Please Hit Subscribe to this podcast Right Now. Also Please Subscribe to the Ben Ferguson Show Podcast and Verdict with Ted Cruz Wherever You get You're Podcasts. Thanks for Listening #seanhannity #hannity #marklevin #levin #charliekirk #megynkelly #tucker #tuckercarlson #glennbeck #benshapiro #shapiro #trump #sexton #bucksexton#rushlimbaugh #limbaugh #whitehouse #senate #congress #thehouse #democrats#republicans #conservative #senator #congressman #congressmen #congresswoman #capitol #president #vicepresident #POTUS #presidentoftheunitedstatesofamerica#SCOTUS #Supremecourt #DonaldTrump #PresidentDonaldTrump #DT #TedCruz #Benferguson #Verdict #maga #presidenttrump #47 #the47morningupdate #donaldtrump #trump #news #trumpnews #Benferguson #breaking #breakingnews #morningupdateYouTube: https://www.youtube.com/@VerdictwithTedCruzSee omnystudio.com/listener for privacy information.

N Engl J Med 2019;381:1411-1421Background Percutaneous coronary intervention (PCI) had been clearly established as the standard of care for ST elevation myocardial infarction. Yet many patients taken for PCI have multiple lesions in addition to the culprit. The benefit of routinely treating additional significant lesions has been unclear, with previous smaller trials showing reductions in composite outcomes primarily driven by reduced revascularization rates.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The COMPLETE (Complete vs Culprit-Only Revascularization Strategies to Treat Multivessel Disease after Early PCI for STEMI) trial investigated whether performing percutaneous coronary intervention (PCI) on non-culprit lesions reduces cardiovascular risk in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease.Patients The trial enrolled 4,041 patients from 140 centers in 31 countries between February 2013 and March 2017. Eligible patients had STEMI with successful culprit-lesion PCI and at least one non-culprit coronary artery lesion with ≥70% stenosis (or 50-69% stenosis with FFR ≤0.80) in a vessel ≥2.5mm in diameter. Patients were randomized within 72 hours after successful culprit-lesion PCI. Exclusion criteria included planned surgical revascularization and previous coronary bypass surgery.Baseline Characteristics The mean age was approximately 62 years, with about 80% being male. Approximately 19% had diabetes, 8% had previous MI, and 7% had previous PCI. Over 90% of patients underwent primary PCI (vs. pharmacoinvasive or rescue PCI), with 80% using radial access.The groups were well-balanced, with similar SYNTAX scores at baseline and similar culprit and non-culprit lesion characteristics. About 76% had one residual diseased vessel and 24% had two or more. Guideline directed medical therapy was robust and balanced, including more than 99% on dual antiplatelet therapy, 98% on statins, 88% on beta blocker, and 85% on ACEi or ARB.In patients in the complete revascularization group designated for non-culprit PCI during index hospitalization, the mean time to PCI was 1 day. In the group designated for non-culprit PCI after discharge, the mean time was 23 days.Trial procedures Patients were randomized to complete revascularization (n=2,016) or culprit-lesion-only PCI (n=2,025). In the complete revascularization group, investigators specified before randomization whether non-culprit PCI would occur during index hospitalization or after discharge (within 45 days).Everolimus-eluting stents were recommended for all procedures. Both groups received guideline-based medical therapy including dual antiplatelet therapy with aspirin and ticagrelor for at least one year.Endpoints The first coprimary outcome was cardiovascular death or new myocardial infarction. The second coprimary outcome was cardiovascular death, myocardial infarction, or ischemia-driven revascularization. Secondary outcomes included individual components of the composite outcomes, all-cause mortality, and safety outcomes like major bleeding, stroke, and stent thrombosis.Trialists estimated that a sample of 4000 patients would give 80% power to detect a 22% lower risk of the composite of cardiovascular death or myocardial infarction in the complete-revascularization group than in the culprit-lesion-only PCI group, assuming an event rate of 5% per year in the culprit-lesion-only PCI group. The first coprimary outcome was tested at a P value of 0.045 and the second at a P value of 0.0119.The co-primary endpoints were analyzed according to the time to first event approach. Confidence intervals for secondary and exploratory efficacy outcomes were not adjusted for multiple comparisons, and therefore inferences drawn from these intervals may not be reproducible.Results Over a median follow-up of 36.2 months, the first coprimary outcome occurred in 7.8% of the complete-revascularization group versus 10.5% of the culprit-lesion-only group (hazard ratio 0.74, 95% CI: 0.60-0.91; p= 0.004). Benefit was driven by reduced myocardial infarction rates (5.4% vs 7.9%) while cardiovascular death rates were similar (2.9% vs 3.2%).The second coprimary outcome was also reduced with complete revascularization (8.9% versus 16.7%, HR: 0.51, 95% CI: 0.43-0.61; p

If You're a FAN leave me a message :-)Episode DescriptionIn this inspiring episode of "15 Minute Mondays," we dive deep into the formula for success, blending luck, talent, grit, and action to unlock your true potential. We provide practical tips to break free from procrastination, build momentum, and achieve your dreams. Whether you're looking to write a book, start a new project, or simply take control of your life, this episode is your guide to turning intention into action.Key Takeaways:Resilience: Learn to bounce back faster from setbacks, understanding that success isn't about perfection.Momentum: Discover how each small step builds confidence and progress, propelling you forward.Fulfillment: Focus on action and effort to feel more in control of your destiny.Results: Over time, the gap between where you are and where you want to be will shrink as you take consistent action.This week, challenge yourself to put the formula into practice. Choose one area of your life and commit to taking consistent, relentless action. Share your journey using #GritAndAction and tag @15MinuteMondays. Let's inspire each other to never give up and take bold steps toward our dreams.Success isn't something you stumble upon, it's something you create. With 1% luck, 1% talent, 98% grit, and 100% action, the life you want is within your reach. But it starts with a decision: Will you show up and do the work?Support the showContact me:Daniel@mindsworx.comwww.mindworx.bizInstagram: @Mindworx_Coaching

PARTICIPATORY MAPPING OF ANIMAL MOBILITY PATTERNS USING FAO'S EPIDEMIOLOGY VALUE CHAIN PLATFORMIntroductionStudies relating to animal movement patterns and are often conducted by academic authors, with dissemination of findings limited to grey literature and scientific journals. Consequently, objectives and outcomes may not incorporate the priorities of surveillance system actors or communicate results to stakeholders. The Food and Agriculture Organisations has developed a digital and interactive medium to facilitate and empower capacity building efforts related to market profiling and animal movement under its Epidemiology Value Chain (EVC) Platform, enabling users to maintain a live, online, and dynamic tool that can store, analyse, and display a magnitude of different data.Materials and methods ‘Open-source' electronic collection systems (e.g.EpiCollect5) allow national veterinary services to enter value chain locations and movement patterns. Data is continuously collected through interviews, expert opinion, or retrospectively via the collation of movement permits. Various ‘plug-in' applications allow for the visualisation of data via maps, statistics, or graphs. These are created in conjunction with national epidemiology units to ensure relevance for selecting and planning intervention options. Lastly, the application allows for dissemination of data to engage key stakeholders. Results Over 1000 bird markets and network connections were identified, profiled, and analysed across Viet Nam, Democratic Republic of the Congo, Ethiopia, Uganda, Rwanda, and Mozambique. Data collection in Ghana continues in conjunction with the national epidemiology unit, including expansion to livestock markets and other value chain nodes.Discussion The mapping of epidemiological significant locations such as markets, abattoirs, and border points along with seasonal and quantified animal movement flows can be utilised by veterinary services to plan and run prevention and control interventions. The tool can rapidly increase country capacities to identify high risk locations, i.e. those in need of urgent biosecurity improvements or those that need to be targeted through surveillance. Furthermore, data can be updated in real-time to maintain the cost efficiency and effectiveness of interventions. R. Aguanno1,2, S. Von Dobschuetz1, S. Khomenko1, A. Tripodi1, W. Kalpravidh1, K. Sumption11Food and Agriculture Organisation of the United Nations, Viale delle Terme di Caracalla, Roma, Italia, 001532 Royal Veterinary College, University College London, 4 Royal College St, London, United Kingdom, NW1 0TUEuFMD Open Sessionwww.eufmdvirtual.com

Candice Ong, the Chief Commercial Officer of ShopBack. ShopBack, the leading rewards and discovery platform in Asia-Pacific, is a pre-shopping portal that enables shoppers to make better purchase decisions. It is a one-stop rewards and discovery platform for users to earn cashback while delivering performance-based marketing to merchants. First launched in Singapore in 2014, ShopBack has since expanded its reach to nine markets across Asia-Pacific. Prior to joining ShopBack, Candice traded the world of investment banking for e-commerce when she made the move into Zalora in 2012. Candice was also a member of the CFE sub-committee on Future Corporate Capabilities and Innovation in 2016 and chaired the retail panel for the ASEAN Business Club Forum in 2015. She echoes the push for greater innovation in Singapore, and firmly hopes that future generations will go on to surpass the ones before them. Discover more details here.Some of the highlights of the episode:[04:25] Engaging local expansion teams during the pandemic[08:45] Collaborating with merchants and managing cancellations and rejections[11:37] Building a network of 4,000 merchants across APAC[14:24] Strategy behind the ShopFest Campaign[16:59] 9.9 Results – Over 400,000 USD in cashback in a single day[22:29] ShopBack's KICK-ON company valuesFollow us on:Instagram: http://bit.ly/2Wba8v7Twitter: http://bit.ly/2WeulzXLinkedin: http://bit.ly/2w9YSQXFacebook: http://bit.ly/2HtryLd

Neurosurgeon Dr. Kurt Yaeger, from Mt. Sinai Hospital in New York, New York, shares insight to being a healthcare worker on the front lines of the COVID-19 pandemic and provides an overview of his recent publication in World Neurosurgery, Patterns of Health Care Costs Due to External Ventricular Drain Infections.Additional Information about this study can be found below.Background: External ventricular drain (EVD) infections are a significant cause of morbidity among neurosurgical patients and have been correlated with increased length of hospital stay and longer requirements for intensive care. To date, no studies have examined the financial impact of EVD infections.Methods: Patients who underwent EVD placement between December 2010 and January 2016 were included in the study. Clinical records were retrospectively reviewed and health care cost data were obtained from the hospital's finance department. Clinical information included patient demographics, details from the hospital course, and outcomes. Total costs, direct/indirect, and fixed/variable costs were analyzed for every patient.Results: Over the 5-year study period, 246 EVDs were placed in 243 patients with an overall infection rate of 9.9% (N = 24). The median EVD duration for infected versus noninfected patients was 19 and 9 days, respectively (P < 0.0001). Median length of intensive care unit stay also was increased for patients with EVD infection (30 days vs. 13 days, P < 0.0001). Total health care costs were significantly greater for infected patients (US$ 168,692 vs. US$ 83,919, P < 0.0001). This trend was comparable for all other cost subtypes, including fixed-direct costs, fixed-indirect costs, variable direct costs, and variable-indirect costs.Conclusions: EVD infection has a substantial effect on clinical morbidity and healthcare costs. These results demonstrate the imperative need to improve EVD infection prevention, particularly in the setting of a value-based health care system.

Finance.In 2019, Uber reported losses for almost $3B. However, the car-sharing app is confident it will reach profitability by 2021.OYO reported a loss of around $300M and is planning to cut down on its spending.No big surprises for Tripadvisor: revenue dropped by 3%, closing at $1.6B.Decline in revenue for Trivago as well (-8%), closing at €838.6M.Tech.Back in 2016, I was working for a web agency offering, among other services, a metasearch engine management tool. My idea, back then, was to combine the experience and the integrations we had by partnering with an AI company to increase the returns of our clients’ campaigns. It never happened (at least, up until I stayed in the agency). Still, I am happy to see that two of my favorite companies out there are doing precisely that: Mirai and TripTease signed a partnership, with the first offering a powerful IBE and the second adding a machine learning layer on top of the campaigns. Results? Over a three-month trial period, on average, conversion rates increased by 22%, and ROAS improved by 41% on average. Good job guys!Another friend, another success: Oaky,​ has partnered with ​Cloudbeds​, creating a two-way integration enabling Oaky to leverage Cloudbeds booking data o send personalized pre-arrival upselling offers to guests. Well done, Eric!Career.Revenue management consulting company, Xotels, is hiring: two cluster RMs, an area RM, a hotel RM, an area revenue executive, and a hotel yeld analyst. You can apply here.Hotel.Due to coronavirus, Expedia suspended listings of Chinese hotels, flights, and local tours. According to ChinaTravelNews, Europe projects 7%-25% less Chinese arrivalsAccording to a recent Kantar survey, over 75% of ads triggered by lodging-related-keywords (such as “NYC Hotels”) belongs to OTAs. So much for becoming less Google-dependent…Vision.“We want to automate the predictable so we can humanize the exceptional,” said Joerg Schuler, Amadeus’ VP of Travel Channels Customer Service, when talking about Amanda, the chatbot Amadeus created to answer travel advisors’ questions. According to Schuler, Amanda can answer 3/4 of the 1,000 questions advisors aks Amadeus support center every day.

Aims/Hypothesis: Early recognition of those at high risk for diabetes as well as diabetes itself can permit preventive management, but many Americans with diabetes are undiagnosed. We sought to determine whether routinely available outpatient random plasma glucose (RPG) would be useful to facilitate the diagnosis of diabetes. Methods: Retrospective cohort study of 942,446 U.S. Veterans without diagnosed diabetes, ≥3 RPG in a baseline year, and ≥1 primary care visit/year during 5-year follow-up. The primary outcome was incident diabetes (defined by diagnostic codes and outpatient prescription of a diabetes drug). Results: Over 5 years, 94,599 were diagnosed with diabetes [DIAB] while 847,847 were not [NONDIAB]. Baseline demographics of DIAB and NONDIAB were clinically similar, except DIAB had higher BMI (32 vs. 28 kg/m2) and RPG (150 vs. 107 mg/dl), and were more likely to have Black race (18% vs. 15%), all p

Introduction: The Dutch Pharmacogenetics Working Group (DPWG) indicated a list of actionable genotypes that affect patients’ response to more 50 drugs; these drugs which show variable effects based on patients’ genetic traits were named as pharmacogenetics (PGX) drugs. Preemptive genetic testing before using these drugs may protect certain patients from serious adverse reactions and could help in avoiding treatment failures. The objectives of this study include identifying the rate of PGX drug usage among Dutch population, estimating the level of users who carry the actionable genotypes and determining the main genes involved in drug’s effect variability. Methods: Usage of PGX drugs over 2011–2017 by the insured population (an average of 11.4 million) in outpatient clinics in Netherlands was obtained from the publically available GIP databank. The data of 45 drugs were analyzed and their interactions with selected pharmacogenes were estimated. Frequency of actionable genotypes of 249 Dutch parents was obtained from the public database: Genome of Netherlands (GoNL), to identify the pattern of genetic characteristics of Dutch population. Results: Over a 7 year period, 51.3 million exposures of patients to PGX drugs were reported with an average of 5.3 exposures per each drug user. One quarterof the exposures (12.4 million) are predicted to be experienced by individuals with actionable genotypes (risky exposures). Up to 60% of the risky exposures (around 7.5 million) were related to drugs metabolized by CYP2D6. SLCO1B1, and CYP2C19 were also identified among the top genes affecting response of drugs users (involved in about 22 and 12.4% of the risky exposures, respectively). Cardiovascular medications were the top prescribed PGX drug class (43%), followed by gastroenterology (29%) and psychiatry/neurology medications (15%). Women use more PGX drugs than men (55.8 vs. 44.2%, respectively) with the majority (84%) of users in both sexes are above 45 years. Conclusion: PGX drugs are commonly used in Netherlands. Preemptive panel testing for CYP2D6, SLCO1B1, and CYP2C19 only could be useful to predict 95% of vulnerable patients’ exposures to PGX drugs. Future studies to assess the economic impact of preemptive panel testing on patients of older age are suggested. Alshabeeb MA, Deneer VHM, Khan A, Asselbergs FW. Use of Pharmacogenetic Drugs by the Dutch Population. Front Genet. 2019;10:567. Published 2019 Jul 2. doi:10.3389/fgene.2019.00567. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Sections of the Abstract, Introduction, and Discussion are presented in the Podcast. Link to the full-text article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614185/

Background: Physicians, particularly in hospitals, suffer from adverse working conditions. There is a close link between physicians' psychosocial work environment and the quality of the work they deliver. Our study aimed to explore whether a participatory work-design intervention involving hospital physicians is effective in improving working conditions and quality of patient care. Methods: A prospective, controlled intervention study was conducted in two surgical and two internal departments. Participants were 57 hospital physicians and 1581 inpatients. The intervention was a structured, participatory intervention based on continuous group meetings. Physicians actively analyzed problematic working conditions, developed solutions, and initiated their implementation. Physicians' working conditions and patients' perceived quality of care were outcome criteria. These variables were assessed by standardized questionnaires. Additional data on implementation status were gathered through interviews. Results: Over the course of ten months, several work-related problems were identified, categorized, and ten solutions were implemented. Post-intervention, physicians in the intervention departments reported substantially less conflicting demands and enhanced quality of cooperation with patients' relatives, compared to control group physicians. Moreover, positive changes in enhanced colleague support could be attributed to the intervention. Regarding patient reports of care quality of care, patient ratings of physicians organization of care improved for physicians in the intervention group. Five interviews with involved physicians confirm the plausibility of obtained results, provide information on implementation status and sustainability of the solutions, and highlight process-related factors for re-design interventions to improve hospital physicians work. Conclusions: This study demonstrates that participatory work design for hospital physicians is a promising intervention for improving working conditions and promoting patient quality of care.

Background: An association between eosinophilic esophagitis (EoE) and celiac disease (CD) has been suggested in the literature. Our aim was to confirm and quantify the association between these two diseases. Methods: All patients in a large Canadian city diagnosed with EoE or CD over a five-year period were identified. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated. Results: Over the five-year study EoE was diagnosed in 421 patients and CD was diagnosed in 763 patients. The incidence of EoE ranged from 2.1 to 10.7 cases per 100,000 population. The incidence of CD ranged from 10.4 to 15.7 cases per 100,000 population. Among the EoE cohort, 83 (20%) cases of EoE and 245 (32%) cases of CD were diagnosed in pediatric patients. The incidence of EoE in the pediatric subpopulation ranged from 3.7 to 6.9 cases per 100,000 population. The incidence of CD in the pediatric subpopulation ranged from 9.5 to 22.7 cases per 100,000 population. The concomitant diagnosis of both EoE and CD was made in three patients, all of whom were pediatric males. The SIR for EoE in the CD cohort was 48.4 (95% CI = 9.73, 141.41) with a SIR for CD within the paediatric EoE cohort of 75.05 (95% CI = 15.08, 219.28). Conclusions: This study confirms the association between EoE and CD. However, this association may be limited to pediatrics where the risk of each condition is increased 50 to 75-fold in patients diagnosed with the alternative condition. The concomitant diagnosis of these conditions should be considered in pediatric patients with upper gastrointestinal symptoms.