Podcasts about ARB

El Flamenco se alía con otras músicas: Orquesta de Córdoba, Trío Arbós, Camerata Flamenco Project, Flamenco Jazz Company, Paco Cepero, José Antonio Rodríguez, José Mercé, Rafael de Utrera...Escuchar audio

If you read Dracula and thought: “I like the ancient shapeshifting nemesis and the homoerotic subtext, but I don’t like how subtle the sexual and national anxieties are,” you’re in luck! Editor, reviewer, and scholar Marisa Mercurio is here to talk about not-so-subtle horrors in Richard Marsh’s 1897 novel The Beetle. Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Guest: Marisa Mercurio Title: The Beetle by Richard Marsh Host:Jake Casella Brookins Music byGiselle Gabrielle Garcia Artwork byRob Patterson Opening poem by Bhartṛhari, translated by John Brough Chopin's "Minute Waltz" performed by Alfred Cortot Berlioz's "Symphonie Fantastique" performed by the Cleveland Orchestra, conducted by Artur Rodzinski References: Kaveh Akbar’s Martyr Daphne Du Maurier's Rebecca & Don't Look Now Alex Woodroe's The Night Ship Tenebrous Press Bram Stoker's Dracula Mary Shelley, Jane Austen, Ann Radcliffe, Charles Dickens, George Eliot E.R. Eddison's Zimianvian trilogy Joseph Conrad’s Heart of Darkness Robert Louis Stevenson’s The Strange Case of Dr. Jekyll & Mr. Hyde Oscar Wilde’s The Picture of Dorian Gray Arthur Conan Doyle’s Sherlock Holmes Kate Beaton’s “The Horror Of The New Woman” H.G. Wells’ The Island of Dr. Moreau Franz Kafka's The Metamorphosis The Fly films (Kurt Neumann 1958; David Cronenberg 1986) Phase IV directed by Saul Bass Robert Repino's Mort(e) The Nest by Gregory A. Douglas, and the “Valancourt Paperbacks from Hell” Mysteries of Udolpho by Ann Radcliffe Jane Austen's Northanger Abbey The Female Detective by Andrew Forrester Wilkie Collins The However Improbable podcast Marisa’s bluesky

We’re closing out this strange year with a “big-picture” episode: editor & critic Dan Hartland is on to talk about trends and directions—or lack thereof—in recent speculative fiction. We talk about the interesting spread of books & awards this year, do some armchair speculating about genre shifts & their accompanying arguments, and have some very insider-baseball discussion of what gets reviewed (or not) and why. And, of course, Dan and Casella talk about their favorite reads from 2025. Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Guest: Dan Hartland Host:Jake Casella Brookins Music byGiselle Gabrielle Garcia Artwork byRob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: Critical Friends podcast Gautam Bhatia's The Sentence Vajra Chandrasekera's Rakesfall Award spread this year- see for instance SFADB Article on UK romantasy sales numbers Romantasy, LitRPG, Progression Fantasy, Baen Books Locus SFT= Speculative Fiction in Translation Strange Horizons issue on the NEA cuts and SFT Richard K. Morgan Orbus by Neal Asher Jenny Hamilton’s work at Reactor AO3= Archive Of Our Own When There Are Wolves Again by E.J. Swift Metal from Heaven by August Clarke Niall Harrison’s review of Swift William Gibson's Sprawl trilogy Hugboxing vs Scab-Picking H.G. Wells Sylvia Park's Luminous Eva Meijer’s Sea Now, tr. Anne Thompson Melo The Booker Prize “Prestige TV in the Time of Climate Change” by Sarah Miller The Sopranos & Breaking Bad The Book of Records by Madeleine Thien Hannah Arendt & Baruch Spinoza John Wyndham & J.G. Ballard The Unworthy by Agustina Bazterrica, tr. Sarah Moses Becky Chambers Colourfields by Paul Kincaid Margaret Killjoy's A Country of Ghosts The Expansion Project by Ben Pester The Goldsmiths Prize Olga Ravn's The Employees Jeff VanderMeer's Area X Ned Beauman BSFA short SF in translation award Translated Hugo Initiative Dengue Boy by Michel Nieva, tr. Rahul Berry Isaac Fellman's Notes from a Regicide Vajra Chandrasekera’s The Saint of Bright Doors Christopher Priest Debbie Urbanski's Portalmania Thomas Ha's Uncertain Sons Ted Chiang's Stories of Your Life and Others Leyna Krow's Sinkhole and Other Inexplicable Voids Ed Park's An Oral History of Atlantis Kelly Link, George Saunders, T.C. Boyle, Nana Kwame Adjei-Brenyah, Elwin Cotman Deep Dream: Science Fiction Exploring the Future of Art, edited by Indrapramit Das Countess by Suzan Palumbo Annie Bot by Sierra Grier Erika Swyler's We Lived On The Horizon Adrian Tchaikovsky, Premee Mohamed Lincoln Michel's Metallic Realms Ed Park’s Same Bed Different Dreams

On this ENCORE of our most popular episode of 2025, hosts Dr. Mojola Omole and Dr. Blair Bigham speak with two authors of the latest “Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care”The discussion reflects a shared urgency: despite past successes, Canada's hypertension control rates are declining. The new guidelines aim to reverse this trend by simplifying diagnosis and treatment for frontline clinicians.Dr. Rémi Goupil, a nephrologist and clinician researcher at Sacré-Cœur Hospital in Montreal, and Dr. Greg Hundemer, a nephrologist and clinician scientist at The Ottawa Hospital, explain that the updated guideline is deliberately designed for primary care providers. They highlight key shifts: lowering the diagnostic threshold for hypertension to  ≥ 130/80 mm Hg, simplifying blood pressure targets, and emphasizing accurate, standardized measurement techniques both in clinic and at home. The guidelines were created with input from a majority-primary care committee—including family physicians, nurses, pharmacists, and patient partners—to ensure clinical applicability.Together, the panel outlines a streamlined nine-step treatment algorithm, emphasizing combination therapy as first-line pharmacologic management. They explain the evidence supporting ARB–thiazide combinations, discuss cost considerations for drug selection, and address adherence challenges. They also explore red flags for secondary hypertension and how the algorithm supports—but does not replace—clinical judgment.For physicians, this guideline offers a clear and practical roadmap: measure blood pressure correctly, aim for systolic pressure below 130 mm Hg, and use the simplified treatment sequence to improve adherence and outcomes. Designed to be easy to implement, the new approach aims to empower primary care providers to act with confidenceComments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

We’re closing out this strange year with a “big-picture” episode: editor & critic Dan Hartland is on to talk about trends and directions—or lack thereof—in recent speculative fiction. We talk about the interesting spread of books & awards this year, do some armchair speculating about genre shifts & their accompanying arguments, and have some very insider-baseball discussion of what gets reviewed (or not) and why. And, of course, Dan and Casella talk about their favorite reads from 2025. Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Guest: Dan Hartland Host:Jake Casella Brookins Music byGiselle Gabrielle Garcia Artwork byRob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: Critical Friends podcast Gautam Bhatia's The Sentence Vajra Chandrasekera's Rakesfall Award spread this year- see for instance SFADB Article on UK romantasy sales numbers Romantasy, LitRPG, Progression Fantasy, Baen Books Locus SFT= Speculative Fiction in Translation Strange Horizons issue on the NEA cuts and SFT Richard K. Morgan Orbus by Neal Asher Jenny Hamilton’s work at Reactor AO3= Archive Of Our Own When There Are Wolves Again by E.J. Swift Metal from Heaven by August Clarke Niall Harrison’s review of Swift William Gibson's Sprawl trilogy Hugboxing vs Scab-Picking H.G. Wells Sylvia Park's Luminous Eva Meijer’s Sea Now, tr. Anne Thompson Melo The Booker Prize “Prestige TV in the Time of Climate Change” by Sarah Miller The Sopranos & Breaking Bad The Book of Records by Madeleine Thien Hannah Arendt & Baruch Spinoza John Wyndham & J.G. Ballard The Unworthy by Agustina Bazterrica, tr. Sarah Moses Becky Chambers Colourfields by Paul Kincaid Margaret Killjoy's A Country of Ghosts The Expansion Project by Ben Pester The Goldsmiths Prize Olga Ravn's The Employees Jeff VanderMeer's Area X Ned Beauman BSFA short SF in translation award Translated Hugo Initiative Dengue Boy by Michel Nieva, tr. Rahul Berry Isaac Fellman's Notes from a Regicide Vajra Chandrasekera’s The Saint of Bright Doors Christopher Priest Debbie Urbanski's Portalmania Thomas Ha's Uncertain Sons Ted Chiang's Stories of Your Life and Others Leyna Krow's Sinkhole and Other Inexplicable Voids Ed Park's An Oral History of Atlantis Kelly Link, George Saunders, T.C. Boyle, Nana Kwame Adjei-Brenyah, Elwin Cotman Deep Dream: Science Fiction Exploring the Future of Art, edited by Indrapramit Das Countess by Suzan Palumbo Annie Bot by Sierra Grier Erika Swyler's We Lived On The Horizon Adrian Tchaikovsky, Premee Mohamed Lincoln Michel's Metallic Realms Ed Park’s Same Bed Different Dreams

La memòria és feble... i a vegades traïdora! Crítica teatral de l'obra «Göteborg», de Jordi Casanovas. Intèrprets: Maria Molins, Roger Coma, Berta Rabascall i Jan Mediavilla. Escenografia: Paula Bosch. Vestuari: Bernat Grau. Il·luminació: Sylvia Kuchinow. Disseny de so: Jordi Salvadó. Spot i video promocional: Lluís Arbós (Dolma Studio). Direcció de producció: Carles Manrique. Direcció tècnica: Àngel Puertas. Ajudantia de producció: Fran Torrella. Regidoria: Montse Alacuart. Perruqueria i maquillatge: Maru Errando. Cap tècnica del teatre: Marta Pérez. Espot i vídeo promocional: Lluís Arbós (Dolma Studio). Màrqueting i comunicació: La Tremenda. Màrqueting i comunicació del teatre: La Villarroel. Reportatge fotogràfic: David Ruano. Disseny gràfic: Maria Picassó. Col·laboradors: Teatre municipal de Canet. Amb el suport de: ICEC-Departament de Cultura de la Generalitat de Catalunya. Distribució: Magnetica Management. És una producció de Velvet Events, S.L. Ajudantia de direcció: Blanca Caminal. Direcció: Jordi Casanovas, Teatre La Villarroel, Barcelona, 23 desembre 2025. Veu: Andreu Sotorra. Música: Enjoy the Silenci. Interpretació: Depeche Mode. Composició: Martin Gore. Àlbum: Violator (Deluxe), 1990.

We’re tracking down the wellspring of “dark academia” in Donna Tartt’s The Secret History, and plucking on threads that stretch out to current fantasy and science fiction literature, with reviewer Roseanna Pendlebury as our guide. Casella manages to throw some shade at Arrival, somehow, and also references Dumb & Dumber.   Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books.   Please consider supporting ARB’s Patreon! Guest: Roseanna Pendlebury Title: The Secret History Host: Jake Casella Brookins Music by Giselle Gabrielle Garcia Artwork by Rob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: Isaac Fellman’s Notes from a Regicide E.J. Swift’s When There Are Wolves Again Ned Beauman’s Venomous Lumpsucker  Rebecca Campbell's Arboreality Simon Roy's Griz Grobus & A Star Called The Sun Ursula Whitcher's North Continent Ribbon Tartt’s The Goldfinch Euripides’ The Bacchae Jane Alison's Meander Spiral Explode: Design and Pattern in Narrative Roger Ebert's review of Roger Avary’s film adaptation of Bret Easton Ellis's The Rules of Attraction (which, we didn’t get into this in the episode, is sort of in the Expanded Secret History Universe) Elizabeth Kostova's The Historian Patricia Highsmith's The Talented Mr. Ripley Oscar Wilde’s The Picture of Dorian Grey J.R.R. Tolkien's Lord of the Rings J.K. Rowling’s Harry Potter Sofia Samatar's The Practice The Horizon and the Chain R.F. Kuang's Katabasis & Babel Fellman's The Two Doctors Górski Marina & Sergei Dyachenko's Vita Nostra, translated by Julia Meitov Hersey Ceaușescu's bathroom Peter Farrelly’s film Dumb and Dumber Sir Arthur Conan Doyles’ Sherlock Holmes story A Study in Scarlet Ted Chiang's "Story of Your Life" vs. Denis Villeneuve's film Arrival Becky Chamber’s To Be Taught if Fortunate Emily Tesh’s The Incandescent Jill Murphy’s The Worst Witch "All art is perfectly useless" C.S. Lewis's Till We Have Faces Samatar's A Stranger In Olondria and The Winged Histories Fellman's The Breath of the Sun Katherin Addison's The Goblin Emperor & sequels Dungeons & Dragons Roseanna’s Small Press Dispatch series at ARB Roseanna's blog Tolkien's Beowulf & The Tolkien Reader Lina Palera’s Seikilos Epitaph with the Lyre of Apollo, CC BY-NC-SA 3.0*   *Note that ARB & AMOT are generally distributed under CC BY-NC-ND 4.0, but will match the CC of any incorporated material for particular posts/episodes.    

We’re tracking down the wellspring of “dark academia” in Donna Tartt’s The Secret History, and plucking on threads that stretch out to current fantasy and science fiction literature, with reviewer Roseanna Pendlebury as our guide. Casella manages to throw some shade at Arrival, somehow, and also references Dumb & Dumber.   Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books.   Please consider supporting ARB’s Patreon! Guest: Roseanna Pendlebury Title: The Secret History Host: Jake Casella Brookins Music by Giselle Gabrielle Garcia Artwork by Rob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: Isaac Fellman’s Notes from a Regicide E.J. Swift’s When There Are Wolves Again Ned Beauman’s Venomous Lumpsucker  Rebecca Campbell's Arboreality Simon Roy's Griz Grobus & A Star Called The Sun Ursula Whitcher's North Continent Ribbon Tartt’s The Goldfinch Euripides’ The Bacchae Jane Alison's Meander Spiral Explode: Design and Pattern in Narrative Roger Ebert's review of Roger Avary’s film adaptation of Bret Easton Ellis's The Rules of Attraction (which, we didn’t get into this in the episode, is sort of in the Expanded Secret History Universe) Elizabeth Kostova's The Historian Patricia Highsmith's The Talented Mr. Ripley Oscar Wilde’s The Picture of Dorian Grey J.R.R. Tolkien's Lord of the Rings J.K. Rowling’s Harry Potter Sofia Samatar's The Practice The Horizon and the Chain R.F. Kuang's Katabasis & Babel Fellman's The Two Doctors Górski Marina & Sergei Dyachenko's Vita Nostra, translated by Julia Meitov Hersey Ceaușescu's bathroom Peter Farrelly’s film Dumb and Dumber Sir Arthur Conan Doyles’ Sherlock Holmes story A Study in Scarlet Ted Chiang's "Story of Your Life" vs. Denis Villeneuve's film Arrival Becky Chamber’s To Be Taught if Fortunate Emily Tesh’s The Incandescent Jill Murphy’s The Worst Witch "All art is perfectly useless" C.S. Lewis's Till We Have Faces Samatar's A Stranger In Olondria and The Winged Histories Fellman's The Breath of the Sun Katherin Addison's The Goblin Emperor & sequels Dungeons & Dragons Roseanna’s Small Press Dispatch series at ARB Roseanna's blog Tolkien's Beowulf & The Tolkien Reader Lina Palera’s Seikilos Epitaph with the Lyre of Apollo, CC BY-NC-SA 3.0*   *Note that ARB & AMOT are generally distributed under CC BY-NC-ND 4.0, but will match the CC of any incorporated material for particular posts/episodes.    

Send us a textThis week we will be talking about the three newly published guidance notes released by the ARB to accompany the new Code of Conduct. This episode content meets PC1 - Professionalism of the Part 3 Criteria.Resources from today's episode:Websites:https://arb.org.uk/architect-information/architects-code-standards-of-conduct-and-practice/https://arb.org.uk/wp-content/uploads/Conflict-of-Interest-guidance-document.pdfhttps://arb.org.uk/wp-content/uploads/Managing-finances-guidance-document.pdfhttps://arb.org.uk/wp-content/uploads/Raising-concerns-and-whistleblowing-guidance-document.pdfThank you for listening! Please follow me on Instagram @part3withme for weekly content and updates or contact me via email me at part3withme@outlook.com or on LinkedIn. Website: www.part3withme.comJoin me next week for more Part3 With Me time.If you liked this episode please give it a rating to help reach more fellow Part3er's!Support the show

Welcome to today's episode, where we dive into two cornerstone classes of antihypertensives: ACE inhibitors and calcium channel blockers. These drugs are among the most frequently prescribed agents in both primary care and specialty settings, making a solid understanding of their practical nuances essential for clinicians, pharmacists, and learners alike. In this episode, we'll break down the most important clinical pearls that can immediately improve your prescribing confidence and patient care. We'll start with ACE inhibitors, a class often selected for patients with hypertension, heart failure, diabetes, and chronic kidney disease. While widely effective, ACE inhibitors come with monitoring requirements and predictable side effect profiles that clinicians must recognize early. We'll highlight what changes in renal function are acceptable, how to navigate issues like hyperkalemia and cough, and when switching to an ARB may be the safest option. Next, we'll move into calcium channel blockers, emphasizing the differences between dihydropyridines and non-dihydropyridines—two groups with distinct effects and unique considerations. I outline amlodipine’s adverse effects and how to navigate a patient who is experiencing edema. By the end of this episode, you'll walk away with a set of high-yield, easy-to-apply pearls that you can use in your next patient encounter. If you use antihypertensives and treat hypertension, heart failure, arrhythmias, or chronic kidney disease, this episode will help sharpen your understanding of these foundational therapies and elevate your medication management strategies. Let's get started. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

Olaf Bello verkörpert Europa. Er hat sich schon in Italien, Albanien und Europa für eine bessere Zukunft eingesetzt. Und nebenbei noch als Journalist Zeitungsartikel, Bücher und Dokumentationen erstellt. Heute ist er Spitzenkandidat von Volt Offenbach und erzählt, wie er Europa erlebt hat, warum er sich für Volt engagiert und was er für Offenbach und Europa plant. Ein Gespräch über Identität, Korruption, politische Neuanfänge und warum Europa noch lange nicht fertig ist.Besprochene Themen:Seine Herkunft aus der Arbëreshë-Minderheit in Italien und seine Motivation, politisch aktiv zu werdenWie er Volt über Online-Spiele kennengelernt hatSeine Rolle als HR-Leiter bei Volt ItalienWarum er Volt Albanien mitgegründet hatDie politische Lage in Albanien: Korruption, EU-Beitrittsprozess, Frauen in der PolitikSein Umzug nach Deutschland und wie er in Offenbach politisch aktiv wurdeWarum er Spitzenkandidat wurde und sein Versprechen: „Inklusion statt Integration“Sein Buch über die Mafia in Deutschland und was die Recherche über Macht, Politik und Vertrauen gelehrt hatSeine Vision für Europa in 10 Jahren und warum er eine europäische Föderation fordertWie junge Menschen in die Politik eingebunden werden können und warum Respekt und Ehrlichkeit der Schlüssel sind

Academic, critic, and prolific podcaster Cameron Kunzelman joins for a far-ranging discussion about how climate fiction, science fiction, and personal and political connections to the environment intersect. Bonus hog sighting. Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Guest: Cameron Kunzelman Title: Venomous Lumpsucker by Ned Beauman Host:Jake Casella Brookins Music byGiselle Gabrielle Garcia Artwork byRob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: Ranged Touch podcasts The World is Born From Zero & Everything is Permitted Sean McTiernan’s SFUltra (Sean was the guest for our Dreams of Amputation episode) From Hell by Alan Moore & Eddie Campbell Steve Moore's Somnium Mark Fisher's Capitalist Realism Christopher Brown's A Natural History of Empty Lots Bill Bryson Abigail Nussbaum Vajra Chandrasekera's Rakesfall Michael Crichton Donna J. Haraway’s Staying With The Trouble Kim Stanley Robinson’s The Ministry for the Future & Aurora (episode on the latter with Hilary Strang) Neal Stephenson's Termination Shock, Seveneves, & Anathem Emily St. John Mandel’s Station Eleven Nicholas Meyer’s film The Day After Nevil Shute's On the Beach Adam McKay’s film Don't Look Up Timothy Morton’s Hyperobjects Trinitite Edward Abbey’s The Monkey Wrench Gang Bruce Sterling, William Gibson, Pat Cadigan “30-50 Feral Hogs” Clock of the Long Now Walt Whitman’s Leaves of Grass John Christopher’s The Death of Grass / No Blade of Grass Benjamín Schultz-Figueroa Describe World Flannery O'Connor Deep ecology Arne Næss Ted Kaczynski #NoDAPL (Dakota Access Pipeline) Bruce Sterling's Islands in the Net Patrick Wright’s The Village That Died For England Centralia coal-seam fire in Pennsylvania Keiichiro Toyama’s Silent Hill & Christophe Gans’ film adaptation Cameron's Bluesky The Assassin's Creed franchise Immanuel Velikovsky Erich von Däniken’s Chariots of the Gods

Academic, critic, and prolific podcaster Cameron Kunzelman joins for a far-ranging discussion about how climate fiction, science fiction, and personal and political connections to the environment intersect. Bonus hog sighting. Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Guest: Cameron Kunzelman Title: Venomous Lumpsucker by Ned Beauman Host:Jake Casella Brookins Music byGiselle Gabrielle Garcia Artwork byRob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: Ranged Touch podcasts The World is Born From Zero & Everything is Permitted Sean McTiernan’s SFUltra (Sean was the guest for our Dreams of Amputation episode) From Hell by Alan Moore & Eddie Campbell Steve Moore's Somnium Mark Fisher's Capitalist Realism Christopher Brown's A Natural History of Empty Lots Bill Bryson Abigail Nussbaum Vajra Chandrasekera's Rakesfall Michael Crichton Donna J. Haraway’s Staying With The Trouble Kim Stanley Robinson’s The Ministry for the Future & Aurora (episode on the latter with Hilary Strang) Neal Stephenson's Termination Shock, Seveneves, & Anathem Emily St. John Mandel’s Station Eleven Nicholas Meyer’s film The Day After Nevil Shute's On the Beach Adam McKay’s film Don't Look Up Timothy Morton’s Hyperobjects Trinitite Edward Abbey’s The Monkey Wrench Gang Bruce Sterling, William Gibson, Pat Cadigan “30-50 Feral Hogs” Clock of the Long Now Walt Whitman’s Leaves of Grass John Christopher’s The Death of Grass / No Blade of Grass Benjamín Schultz-Figueroa Describe World Flannery O'Connor Deep ecology Arne Næss Ted Kaczynski #NoDAPL (Dakota Access Pipeline) Bruce Sterling's Islands in the Net Patrick Wright’s The Village That Died For England Centralia coal-seam fire in Pennsylvania Keiichiro Toyama’s Silent Hill & Christophe Gans’ film adaptation Cameron's Bluesky The Assassin's Creed franchise Immanuel Velikovsky Erich von Däniken’s Chariots of the Gods

Nell'ultima tappa del percorso di Road To Social Change, organizzato insieme alla Banking Academy di UniCredit, siamo stati a Verona per parlare di Turismo. Insieme ad Ada Rosa Balzan, Independent Expert alle Nazioni Unite e oggi alla guida di ARB, abbiamo parlato di come il turismo è cambiato negli ultimi anni e di come possiamo promuovere un approccio di sostenibilità integrale anche in questo settore Learn more about your ad choices. Visit megaphone.fm/adchoices

ARB on new draft Code for Gambling Advertising. Gail Schimmel, ARB CEO Spoke to Clarence Ford. Views and News with Clarence Ford is the mid-morning show on CapeTalk. This 3-hour long programme shares and reflects a broad array of perspectives. It is inspirational, passionate and positive. Host Clarence Ford’s gentle curiosity and dapper demeanour leave listeners feeling motivated and empowered. Known for his love of jazz and golf, Clarrie covers a range of themes including relationships, heritage and philosophy. Popular segments include Barbs’ Wire at 9:30am (Mon-Thurs) and The Naked Scientist at 9:30 on Fridays. Thank you for listening to a podcast from Views & News with Clarence Ford Listen live on Primedia+ weekdays between 09:00 and 12:00 (SA Time) to Views and News with Clarence Ford broadcast on CapeTalk https://buff.ly/NnFM3Nk For more from the show go to https://buff.ly/erjiQj2 or find all the catch-up podcasts here https://buff.ly/BdpaXRn Subscribe to the CapeTalk Daily and Weekly Newsletters https://buff.ly/sbvVZD5 Follow us on social media: CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567See omnystudio.com/listener for privacy information.

Vampire scholar, science fiction studies editor, and ARB co-founder Sean Guynes joins to discuss Kostova's 2005 historical vampire thriller. We both have fairly negative opinions of the book, but it did lead us to talk about what historical thrillers are (or are not) theorizing, vampire novels we like more, and much else besides.Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books.Please consider supporting ARB's Patreon!Guest: Sean GuynesTitle: The Historian by Elizabeth KostovaHost: Jake Casella BrookinsMusic by Giselle Gabrielle GarciaArtwork by Rob PattersonOpening poem by Bhartṛhari, translated by John BroughTranscribers: Kate Dollarhyde and John WM ThompsonReferences:David Linday's Voyage to ArcturusSean's series on the Ballantine Adult Fantasy booksThomas Burnett SwannE.R. EddisonGibson's Bridge trilogyStephen Norrington's film BladeBram Stoker's DraculaDan Brown's The Da Vinci CodeR.F. Kuang's KatabasisSarah Perry's Melmoth and our episode with Jon Greenaway about itIlana Masad's “Holocaust Beach Reads”Machiavelli's The PrinceRadu Florescu & Raymond McNally's In Search of DraculaThe Turkey City LexiconAnne Rice's Vampire Chronicles, including Memnoch the DevilFred Saberhagen's The Dracula TapeChelsea Quinn Yarbro's St. Germaine cycleE. Elias Merhige's film Shadow of the VampireClaire Kohda's Woman, EatingIndrapramit Das's The DevourersStephen Graham Jones' The Buffalo Hunter HunterPeter S. Beagle's A Fine and Private PlaceEddison's the The Mezentian GateAnd be sure to check out Sean's essay on The Historian!

Vampire scholar, science fiction studies editor, and ARB co-founder Sean Guynes joins to discuss Kostova's 2005 historical vampire thriller. We both have fairly negative opinions of the book, but it did lead us to talk about what historical thrillers are (or are not) theorizing, vampire novels we like more, and much else besides.Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books.Please consider supporting ARB's Patreon!Guest: Sean GuynesTitle: The Historian by Elizabeth KostovaHost: Jake Casella BrookinsMusic by Giselle Gabrielle GarciaArtwork by Rob PattersonOpening poem by Bhartṛhari, translated by John BroughTranscribers: Kate Dollarhyde and John WM ThompsonReferences:David Linday's Voyage to ArcturusSean's series on the Ballantine Adult Fantasy booksThomas Burnett SwannE.R. EddisonGibson's Bridge trilogyStephen Norrington's film BladeBram Stoker's DraculaDan Brown's The Da Vinci CodeR.F. Kuang's KatabasisSarah Perry's Melmoth and our episode with Jon Greenaway about itIlana Masad's “Holocaust Beach Reads”Machiavelli's The PrinceRadu Florescu & Raymond McNally's In Search of DraculaThe Turkey City LexiconAnne Rice's Vampire Chronicles, including Memnoch the DevilFred Saberhagen's The Dracula TapeChelsea Quinn Yarbro's St. Germaine cycleE. Elias Merhige's film Shadow of the VampireClaire Kohda's Woman, EatingIndrapramit Das's The DevourersStephen Graham Jones' The Buffalo Hunter HunterPeter S. Beagle's A Fine and Private PlaceEddison's the The Mezentian GateAnd be sure to check out Sean's essay on The Historian!

I ftuar në “Live From Tirana” me Ronaldo Sharkën, ka qenë Arbër Dervishaj, i riu që është bërë viral në rrjete sociale nga mënyra e tij unike e të reklamuarit. Mbi të gjitha, Arbër u bë i njohur edhe nga një video ku kundërshtonte kryeministrin Edi Rama në një takim me studentë, duke e quajtur atë ‘mashtruesi më i madh’…

Writer, scholar, and academic organizer E.F. McAdam joins to talk about human evolution & extinction, AI, pseudo-science, and much more in Kawakami’s very strange and really quite funny far-future novel. Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Guest: Eleanor McAdam Title: Under The Eye Of The Big Bird by Hiromi Kawakami, translated by Asa Yoneda Host: Jake Casella Brookins Music by Giselle Gabrielle Garcia Artwork by Rob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: Current Research in Science Fiction Vanishing World by Sayaka Murata, translated by Ginny Tapley Takemori Annie Bot by Sierra Greer Emily Tesh’s The Incandescent and Some Desperate Glory Niall Harrison’s Locus review of Under The Eye Of The Big Bird Adrian Tchaikovsky's Service Model J.G. Ballard Stephen Baxter's Evolution William Hope Hogdson's The Night Land X-Men Isaac Asimov's Foundation Margaret Atwood MaddAddam Trilogy Kurt Vonnegut Jr.’s Cat's Cradle Erika Swyler's We Lived On The Horizon Kazuo Ishiguro’s Klara and the Sun & Never Let Me Go Adrian Tchaikovsky's Children of Time          Text  - HTML . com Convert your visual text documents to HTML code instantly. Edit and clean your markup with a couple of clicks. How to use the Text to HTML converter? Paste a visual document to the left to convert it to HTML Paste your HTML code it the right to preview the document Press the Clean button to execute the checked HTML cleaning options. Erase the page to get started.    

Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books.Please consider supporting ARB's Patreon!Guest: Eleanor McAdamTitle: Under The Eye Of The Big Bird by Hiromi Kawakami, translated by Asa YonedaHost: Jake Casella BrookinsMusic by Giselle Gabrielle GarciaArtwork by Rob PattersonOpening poem by Bhartṛhari, translated by John BroughTranscribers: Kate Dollarhyde and John WM ThompsonReferences:Current Research in Science FictionVanishing World by Sayaka Murata, translated by Ginny Tapley TakemoriAnnie Bot by Sierra GreerEmily Tesh's The Incandescent and Some Desperate GloryNiall Harrison's Locus review of Under The Eye Of The Big BirdAdrian Tchaikovsky's Service ModelJ.G. BallardStephen Baxter's EvolutionWilliam Hope Hogdson's The Night LandX-MenIsaac Asimov's FoundationMargaret Atwood MaddAddam TrilogyKurt Vonnegut Jr.'s Cat's CradleErika Swyler's We Lived On The HorizonKazuo Ishiguro's Klara and the Sun & Never Let Me GoAdrian Tchaikovsky's Children of Time

Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books.Please consider supporting ARB's Patreon!Guest: Timothy MooreTitle: 60 Stories by Donald BarthelmeHost: Jake Casella BrookinsMusic by Giselle Gabrielle GarciaArtwork by Rob PattersonOpening poem by Bhartṛhari, translated by John BroughTranscribers: Kate Dollarhyde and John WM ThompsonReferences:Timothy Moore's I Will Teach You RetributionJoan Lindsay's Picnic at Hanging Rock & Peter Weir's film adaptationMolly Templeton's Bluesky request for Australian Gothic“Intermittent Anhedonia”Ethan Rutherford's North SunEvening House Books"The School"Close Reading for the 21st Century edited by Dan Sinykin & Johanna WinantAlduous Huxley's Brave New World"The Lottery""Me and Miss Mandible""A Shower of Gold""Eugénie Grandet"Sidney Lumet's Network"The Balloon""The Great Hug"We somehow completely failed to reference E.E. Cumming's “In Just – spring” for balloon-man reasonsKeita Takahashi's Katamari DamacyUb Iwerk's Balloon LandWill McMahon“A Manual for Sons”Barthelme's The Dead FatherWes Anderson's The Life Aquatic"The Policeman's Ball"Vercingetorix"The King of Jazz"Julio CortázarIshmael ReedKelly LinkEd ParkElwin CotmanNana Kwame Adjei-BrenyahAimee Bender's Girl in the Flammable SkirtGeorge SaundersGarielle LutzDalkey ArchivesSmall Beer PressZachary Gillan &  our Authority episode“Reading Weird Fiction in a Time of Fascism”Mircea Cărtărescu's Solenoid, translated by Sean CotterLiliana Costanzi's You Glow in the DarkThomas Ha's Uncertain SonsEd Park's An Oral History of AtlantisBrian Evenson“Lonely Rolling Star” by Saki Kabata and Yoshihito Yano off the first Katamari gameBilly Bletcher as the Pincushion Man in Ub Iwerks' Balloon Land, music by Carl Staling“You're the Cream in My Coffee” recorded by Miff Mole and His Little Molers“Perdido Street Blues” by Louis Armstrong and Sydney BechetCharlie Parker's “Billie's Bounce”

Barthelme’s surreal, post-modern writing was massively influential for the short story market and for evolving conceptions of literary realism and irrealism, but he’s not often discussed in speculative circles. Author & teacher Timothy Moore is on to help rectify that: we dig into some of our favorites from this landmark connection, with lots of spitballing about the limits of interpretation. Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Guest: Timothy Moore Title: 60 Stories by Donald Barthelme Host: Jake Casella Brookins Music by Giselle Gabrielle Garcia Artwork by Rob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: Timothy Moore’s I Will Teach You Retribution Joan Lindsay’s Picnic at Hanging Rock & Peter Weir’s film adaptation Molly Templeton’s Bluesky request for Australian Gothic “Intermittent Anhedonia” Ethan Rutherford's North Sun Evening House Books "The School" Close Reading for the 21st Century edited by Dan Sinykin & Johanna Winant Alduous Huxley’s Brave New World "The Lottery" "Me and Miss Mandible" "A Shower of Gold" "Eugénie Grandet" Sidney Lumet’s Network "The Balloon" "The Great Hug" We somehow completely failed to reference E.E. Cumming’s “In Just – spring” for balloon-man reasons Keita Takahashi's Katamari Damacy Ub Iwerk’s Balloon Land Will McMahon “A Manual for Sons” Barthelme’s The Dead Father Wes Anderson’s The Life Aquatic "The Policeman's Ball" Vercingetorix "The King of Jazz" Julio Cortázar Ishmael Reed Kelly Link Ed Park Elwin Cotman Nana Kwame Adjei-Brenyah Aimee Bender's Girl in the Flammable Skirt George Saunders Garielle Lutz Dalkey Archives Small Beer Press Zachary Gillan &  our Authority episode “Reading Weird Fiction in a Time of Fascism” Mircea Cărtărescu's Solenoid, translated by Sean Cotter Liliana Costanzi’s You Glow in the Dark Thomas Ha's Uncertain Sons Ed Park's An Oral History of Atlantis Brian Evenson “Lonely Rolling Star” by Saki Kabata and Yoshihito Yano off the first Katamari game Billy Bletcher as the Pincushion Man in Ub Iwerks’ Balloon Land, music by Carl Staling “You’re the Cream in My Coffee” recorded by Miff Mole and His Little Molers “Perdido Street Blues” by Louis Armstrong and Sydney Bechet Charlie Parker’s “Billie’s Bounce”    

Një emision ku si asnjëherë më parë mendimet dhe fjalët vijnë si në jetë, të pacensuruara…Mirë, ndoshta pak të censuruara. “Pardon my French” nga Jonida Alickolli, të cilës i bashkohet në moderim Arbër Çepani, ku e vetmja gjë që nuk dinë të bëjnë është të flasin frengjisht! Surpriza e këtij sezoni është Lei Kraja. Moderatorja i bashkohet dyshes sonë dhe një gjë është e sigurtë, të qeshurat dhe surprizat janë të garantuara.

Një emision ku si asnjëherë më parë mendimet dhe fjalët vijnë si në jetë, të pacensuruara…Mirë, ndoshta pak të censuruara. “Pardon my French” nga Jonida Alickolli, të cilës i bashkohet në moderim Arbër Çepani, ku e vetmja gjë që nuk dinë të bëjnë është të flasin frengjisht! Surpriza e këtij sezoni është Lei Kraja. Moderatorja i bashkohet dyshes sonë dhe një gjë është e sigurtë, të qeshurat dhe surprizat janë të garantuara.

Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books.Please consider supporting ARB's Patreon!Guest: Ursula WhitcherTitle: Burning Bright by Melissa ScottHost: Jake Casella BrookinsMusic by Giselle Gabrielle GarciaArtwork by Rob PattersonOpening poem by Bhartṛhari, translated by John BroughTranscribers: Kate Dollarhyde and John WM ThompsonReferences:North Continent RibbonIndra Das's The Last Dragoners of BowbazarFonda Lee's Green Bone books & game thereof w/ James Mendez HodesBruce Coville's Aliens Ate My Homework & Jeremy Thatcher, Dragon HatcherThomas Ha's Uncertain SonsScott's Trouble And Her Friends & Astreiant series, most recently Point of HeartsC.S. Lewis's PerelandraMargaret Weis & Tracy Hickman's Dragonlance novelsDon Daglow's Neverwinter NightsCommedia dell'arteThe Marvel Cinematic Universe franchiseLAN partiesC.J. Cherryh's Foreigner booksArkardy Martine's Teixcalaan booksIain M. Banks' Player of GamesNeal Stephenson's Snow CrashCameron Reed's Fortunate FallIain Softley's HackersWilliam Gibson's Blue Ant trilogyCharlie Jane AndersBruce SterlingMichael Swanwick's Stations of the TideUrsula's website & Bluesky

Combining cyberpunk, space opera, and a strong interest in artistic creation and gaming, Burning Bright is an unusual SF novel from a very specific era. Author Ursula Whitcher joins us to talk about the novel’s many strange facets, its fascination with endings, and its connections to developments elsewhere in gaming and science fiction. Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Guest: Ursula Whitcher Title: Burning Bright by Melissa Scott Host: Jake Casella Brookins Music by Giselle Gabrielle Garcia Artwork by Rob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: North Continent Ribbon Indra Das’s The Last Dragoners of Bowbazar Fonda Lee's Green Bone books & game thereof w/ James Mendez Hodes Bruce Coville's Aliens Ate My Homework & Jeremy Thatcher, Dragon Hatcher Thomas Ha's Uncertain Sons Scott’s Trouble And Her Friends & Astreiant series, most recently Point of Hearts C.S. Lewis's Perelandra Margaret Weis & Tracy Hickman’s Dragonlance novels Don Daglow’s Neverwinter Nights Commedia dell'arte The Marvel Cinematic Universe franchise LAN parties C.J. Cherryh's Foreigner books Arkardy Martine's Teixcalaan books Iain M. Banks' Player of Games Neal Stephenson's Snow Crash Cameron Reed's Fortunate Fall Iain Softley’s Hackers William Gibson's Blue Ant trilogy Charlie Jane Anders Bruce Sterling Michael Swanwick's Stations of the Tide Ursula's website & Bluesky

Ob als Schauspielerin, Therapeutin oder Drehbuchautorin – alles, was Franziska von Arb anpackt, tut sie mit Feuer, Leidenschaft und unerschütterlicher Intensität. Schon mit zwölf Jahren wusste sie, dass sie Schauspielerin werden wollte. Ihr Traum: eines Tages auf den ganz grossen Bühnen zu stehen. Entschlossen verfolgte sie diesen Weg, absolvierte die Schauspielschule und spielte zunächst in Kleintheatern. Als sie schliesslich auf der ersehnten grossen Bühne stand, kam die Ernüchterung – der Abstand zum Publikum war zu gross, die Nähe zu den Menschen fehlte. Diese Erkenntnis stürzte sie in eine Lebenskrise. Auf der Suche nach Sinn und einer neuen Richtung brach Franziska von Arb zu einer langen Reise durch Amerika auf. Unter dem endlosen Sternenhimmel kam die Eingebung: Psychologie. Nach dem Studium und der Ausbildung zur Psychotherapeutin spezialisierte sie sich auf Traumatherapie. Sie führt nun seit vielen Jahren eine eigene Praxis und ist neben ihrer therapeutischen Arbeit mit dem «Hirntheater» unterwegs, ihrem interaktiven Theaterensemble, das sich auf Themen im Bereich der Demenz spezialisiert hat. Aber auch sonst brennt der künstlerische Funke weiter: Nach einer Ausbildung zur Drehbuchautorin schreibt Franziska von Arb an Spielfilmen und Serien, um Geschichten auch filmisch zum Leben zu erwecken. In Musik für einen Gast bei Eva Oertle erzählt Franziska von Arb, wie sie schon während der Schauspielausbildung Aidskranke im Lighthouse Basel betreut hat, warum sie immer wieder um ihre Stimme kämpfen musste und wie sich ihre therapeutische und ihre künstlerische Arbeit gegenseitig beeinflussen. Die Musiktitel: 1. Mani Matter - Si hei der Wilhälm Täll ufgfüert [= sie haben Wilhelm Tell aufgeführt] 2. Ambäck – Verändler (Andreas Gabriel, Violine / Markus Flückiger, Schwyzerörgeli / Pirmin Huber, Kontrabass) 3. Marla Glen – The Cost Of Freedom 4. Bait Jaffe Klezmer Orchestra – David's Bulgar von Sascha Schönhaus 5. Bait Jaffe Klezmer Orchestra featuring Ana María Pérez Jiménez - Esta Montagna d'enfrente Das eingespielte Lied: Franziska Maria von Arb – Gschichtebeeri (Geschichten-Beere) aus Bärlauch von StimmKontraBass

Trevor Pumnea, Executive Director, Northland Arboretum, talks about the latest happenings at the Arboretum. Trevor gave an update on the new Bike Park that was installed last spring, he discussed the possibility of Forest Ice Skating coming this winter to the Arb, weather permitting. Trevor listed a number of classes and events that were taking place at the Arb that the public could take part in, and he invited the public to their annual fundraising Haunted Trail Weekend and Low Scare Trunk or Treat event. He also discussed memberships and volunteer opportunities available at the Arb.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Fresh off the release of her book Diverse Futures: Science Fiction and Author of Color, Joy Sanchez-Taylor joins the podcast to discuss Jemisin’s The Fifth Season, a landmark book in SFF. Lots to talk about here: in terms of how the entire trilogy is tackling ideas about race and oppression, Jemisin’s approach to structure and genre categories, and The Fifth Season’s significance and ongoing legacy. Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Guest: Joy Sanchez-Taylor Title: The Fifth Season by N.K. Jemisin Host: Jake Casella Brookins Music by Giselle Gabrielle Garcia Artwork by Rob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: Diverse Futures: Science Fiction and Author of Color Routledge Handbook of Co-Futurisms Dispelling Fantasies: Author of Color Re-Imagine a Genre Ibi Zoboi's Skin Examples of YA novels in verse from the Boston Public Library Liliana Colanzi You Glow in the Dark, translated by Chris Andrews Center for Fiction Brooklyn Puppygate Jemisin’s 2018 Hugo Acceptance Speech Sylvia Moreno Garcia, Nnedi Okorafor, Nghi Vo Jemisin's Inheritance Trilogy, The City We Became Tomi Adeyemi’s Children of Blood and Bone Moses Ose Utomi’s The Lies of the Ajungo Ursula K. Le Guin’s “The Ones Who Walk Away From Omelas” Octavia E. Butler’s Parable series The Elder Scrolls games Morrowind & Skyrim Jemisin on race in Skyrim Marlon James’ Black Leopard, Red Wolf Latinx Visions Conference, Nov 3-7 Marianna Enriquez Ananda Lima's Craft Colson Whitehead, Amal El-Mohtar Nghi Vo's Singing Hills & The City In Glass Joy’s Bluesky Suzan Palumbo, Zig Zag Claybourne VICFA World Fantasy Convention  

Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books.Please consider supporting ARB's Patreon!Guest: Joy Sanchez-TaylorTitle: The Fifth Season by N.K. JemisinHost: Jake Casella BrookinsMusic by Giselle Gabrielle GarciaArtwork by Rob PattersonOpening poem by Bhartṛhari, translated by John BroughTranscribers: Kate Dollarhyde and John WM ThompsonReferences:Diverse Futures: Science Fiction and Author of ColorRoutledge Handbook of Co-FuturismsDispelling Fantasies: Author of Color Re-Imagine a GenreIbi Zoboi's SkinExamples of YA novels in verse from the Boston Public LibraryLiliana Colanzi You Glow in the Dark, translated by Chris AndrewsCenter for Fiction BrooklynPuppygateJemisin's 2018 Hugo Acceptance SpeechSylvia Moreno Garcia, Nnedi Okorafor, Nghi VoJemisin's Inheritance Trilogy, The City We BecameTomi Adeyemi's Children of Blood and BoneMoses Ose Utomi's The Lies of the AjungoUrsula K. Le Guin's “The Ones Who Walk Away From Omelas”Octavia E. Butler's Parable seriesThe Elder Scrolls games Morrowind & SkyrimJemisin on race in SkyrimMarlon James' Black Leopard, Red WolfLatinx Visions Conference, Nov 3-7Marianna EnriquezAnanda Lima's CraftColson Whitehead, Amal El-MohtarNghi Vo's Singing Hills & The City In GlassJoy's BlueskySuzan Palumbo, Zig Zag ClaybourneVICFAWorld Fantasy Convention

El Partido Popular celebra hoy una sesión monográfica en el Senado contra la violencia de género, haciendo valer su mayoría. Se aborda el tema de las pulseras antimaltrato, que según la memoria de la Fiscalía, han fallado. En el audio se escucha a diferentes locutores de COPE, que repasan las noticias del día en varios ámbitos. Se comenta el incendio en Bendilla de Arbás, provocado en siete puntos, y los incendios en Galicia, especialmente en la provincia de Lugo. También se informa sobre la situación migratoria en Canarias, donde Miguel Tellado, del PP, pide medidas para contrarrestar la inmigración ilegal. En el ámbito internacional, se analiza la tensión entre Moscú y la OTAN tras la violación del espacio aéreo por parte de cazas rusos. En deportes, el Real Madrid mantiene un pleno de victorias en LaLiga y se repasa la jornada futbolística. Finalmente, el audio dedica un amplio espacio a recordar la trayectoria de Joaquín Prat y Pepe Domingo Castaño en COPE, y se entrevista a ...

In this episode, we review the newly published 2025 ACC/AHA hypertension guidelines. Key Concepts Instead of the Pooled Cohort Equations (PCE) from 2013, the 2025 hypertension guidelines recommend a new risk equation called PREVENT, which incorporates new risk factors and does not include race as part of the risk calculation. The guidelines recommend starting two antihypertensive medications for initial therapy in stage II hypertension and one antihypertensive medication for stage I hypertension. The guidelines no longer recommend specific first-line therapies for black patients. Instead, all patients without compelling indications should be initiated on a thiazide, ACE inhibitor, ARB, or dihydropyridine calcium channel blocker regardless of race/ethnicity. All patients should have a blood pressure goal of < 130/80 mmHg. Some patients may consider a more stringent goal of < 120/80 if they have diabetes or are at a higher risk of future ASCVD events. References Jones DW, Ferdinand KC, Taler SJ, Johnson HM, Shimbo D, Abdalla M, Altieri MM, Bansal N, Bello NA, Bress AP, Carter J, Cohen JB, Collins KJ, Commodore-Mensah Y, Davis LL, Egan B, Khan SS, Lloyd-Jones DM, Melnyk BM, Mistry EA, Ogunniyi MO, Schott SL, Smith SC Jr, Talbot AW, Vongpatanasin W, Watson KE, Whelton PK, Williamson JD. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2025 Aug 14. doi: 10.1161/CIR.0000000000001356. Epub ahead of print. PMID: 40811497.

Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books.Please consider supporting ARB's Patreon!Guest: Zachary GillanTitle: Authority by Jeff VanderMeerHost: Jake Casella BrookinsMusic by Giselle Gabrielle GarciaArtwork by Rob PattersonOpening poem by Bhartṛhari, translated by John BroughTranscribers: Kate Dollarhyde and John WM ThompsonReferences:Zach's Profane Illuminations column at ARBRobert AickmanBothayna Al-Essa's The Book-Censor's Library, translated by Ranya Abdelrahman & Sawad HussainBohumil Hrabal's Too Loud A Solitude, translated by Michael Henry HeimAnnihilation, Acceptance, and AbsolutionVanderMeer's blogVanderMeer's Ambergris: City of Saints and Madmen; Shriek: An Afterword; FinchAnn & Jeff VanderMeer's The Weird: A Compendium of Strange and Dark StoriesMKUltraStanislaw Lem's Solaris, translated by Joanna Kilmartin and Steve Cox (from Jean-Michel Jasiensko's French translation) and Bill Johnston (from the Polish)Boris & Arkady Strugatsky's Roadside Picnic, translated by Olena BormashenkoAndrei Tarkovsky's Solaris and StalkerAlex Garland's AnnihilationCormac McCarthy's The RoadKay Chronister's Desert CreaturesRoland Emmerich's The Day After TomorrowDamon Lindelof and Tom Perrotta's The LeftoversBruce Timm and Eric Radomski's Batman: the Animated SeriesTimothy Morton's Dark Ecology and other workVanderMeer's Hummingbird SalamanderThomas Ha's Uncertain SonsJean-Pierre Jeunet's Le Fabuleux Destin d'Amélie Poulain

Picking the second book as an entry point into Area X, weird scholar and normal ARB editor Zachary Gillan is on the pod to talk about Jeff VanderMeer’s work and how the New Weird is more than just ecological anxiety. (Though it might be that, too.) Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Guest: Zachary Gillan Title: Authority by Jeff VanderMeer Host: Jake Casella Brookins Music by Giselle Gabrielle Garcia Artwork by Rob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson References: Zach’s Profane Illuminations column at ARB Robert Aickman Bothayna Al-Essa’s The Book-Censor's Library, translated by Ranya Abdelrahman & Sawad Hussain Bohumil Hrabal’s Too Loud A Solitude, translated by Michael Henry Heim Annihilation, Acceptance, and Absolution VanderMeer’s blog VanderMeer’s Ambergris: City of Saints and Madmen; Shriek: An Afterword; Finch Ann & Jeff VanderMeer’s The Weird: A Compendium of Strange and Dark Stories MKUltra Stanislaw Lem’s Solaris, translated by Joanna Kilmartin and Steve Cox (from Jean-Michel Jasiensko’s French translation) and Bill Johnston (from the Polish) Boris & Arkady Strugatsky’s Roadside Picnic, translated by Olena Bormashenko Andrei Tarkovsky's Solaris and Stalker Alex Garland's Annihilation Cormac McCarthy's The Road Kay Chronister's Desert Creatures Roland Emmerich’s The Day After Tomorrow Damon Lindelof and Tom Perrotta’s The Leftovers Bruce Timm and Eric Radomski’s Batman: the Animated Series Timothy Morton’s Dark Ecology and other work VanderMeer’s Hummingbird Salamander Thomas Ha's Uncertain Sons Jean-Pierre Jeunet’s Le Fabuleux Destin d'Amélie Poulain  

In this episode of the Overland Journal Podcast, host Scott Brady sits down with renowned overland photographer Michael Ellem. The two discuss their shared adventures across Australia, including remote and technical tracks like Cape York and the Canning Stock Route. Michael, who has been ARB's principal photographer for decades, shares his expertise in capturing the perfect shot, his loyalty to the ARB brand, and the importance of following one's creative passion. They also delve into Michael's favorite travel destinations in Australia, his approach to overlanding, and the specifics of his highly modified 70 series Land Cruiser. Special thanks to podcast sponsors Onyx, Hankook Tires and Warner Ineos.

Years ago, Laura and Pino Pugliano gifted bottles of olive oil at their wedding—never imagining it would inspire a thriving business. Our episode traces their heartfelt journey, where romance and tradition intertwine, from the charm of a small Italian town to the bustling enterprise they run today. As we explore their story, we also uncover the rich heritage of Vena di Maida, where Albanian and Italian cultures have coexisted since the 1400s. The Arbëreshë community, with its enduring language, customs, and recipes, illustrates how migration shaped Italy's cultural mosaic of resilience and continuity. Our journey then turns to Calabria's lush olive groves, where the ancient art of olive oil production still thrives. From its sacred uses in Rome to its place at modern tables, olive oil remains a timeless symbol of nourishment and identity. We highlight its health benefits, economic role, and the importance of sustainability—challenging listeners to value authentic, high-quality oils that honor Italy's agricultural legacy.      CICCIO'S OLIVES SOCIALS Instagram: @cicciosolives YouTube:  @cicciosolives  X: @CicciosOlives Facebook: https://www.facebook.com/CicciosOlives/   THEIR WEBSITE: https://cicciosolives.com/

Ether inches closer to all-time highs as several bullish indicators align to support a rally into price discovery in the coming days.~This Episode is Sponsored By Coinbase~ Buy $50 & Get $50 for getting started on Coinbase➜ https://bit.ly/CBARRON00:00 Intro00:10 Sponsor: Coinbase00:42 Rate cut race01:30 Scott Bessent: Good chance of 50% rate cut in Sept.03:15 April 202504:00 Nobody knows anything05:00 Cathie Wood: Why I bought $BMNR06:50 Staked ETH vs Bitcoin08:50 Cathie Wood: Cathie sold SOL for ETH09:55 ETH vs SOL11:45 L2s up next: $ARB & $OP12:50 Tokenized stocks13:40 Charts14:50 Outro#crypto #ethereum #bitcoin~Ethereum Nears All-Time High!

Welcome to another exciting episode of the Jeep Talk Show! This week, we dive deep into the world of airing down – a key off-roading technique to boost traction and conquer tough terrains like rocks, sand, and mud. Join hosts Tony and Greg as they debunk common airing down myths, share expert tips, and discuss the importance of tire selection, construction, and pressure management for your Jeep. Whether you're a seasoned Jeeper or new to the trails, this episode is packed with insights to elevate your off-road game!

Send us a text—This is an encore presentation of an episode previously published June 30—On this episode of the CMAJ Podcast, hosts Dr. Mojola Omole and Dr. Blair Bigham speak with two authors of the latest “Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care”The discussion reflects a shared urgency: despite past successes, Canada's hypertension control rates are declining. The new guidelines aim to reverse this trend by simplifying diagnosis and treatment for frontline clinicians.Dr. Rémi Goupil, a nephrologist and clinician researcher at Sacré-Cœur Hospital in Montreal, and Dr. Greg Hundemer, a nephrologist and clinician scientist at The Ottawa Hospital, explain that the updated guideline is deliberately designed for primary care providers. They highlight key shifts: lowering the diagnostic threshold for hypertension to  ≥ 130/80 mm Hg, simplifying blood pressure targets, and emphasizing accurate, standardized measurement techniques both in clinic and at home. The guidelines were created with input from a majority-primary care committee—including family physicians, nurses, pharmacists, and patient partners—to ensure clinical applicability.Together, the panel outlines a streamlined nine-step treatment algorithm, emphasizing combination therapy as first-line pharmacologic management. They explain the evidence supporting ARB–thiazide combinations, discuss cost considerations for drug selection, and address adherence challenges. They also explore red flags for secondary hypertension and how the algorithm supports—but does not replace—clinical judgment.For physicians, this guideline offers a clear and practical roadmap: measure blood pressure correctly, aim for systolic pressure below 130 mm Hg, and use the simplified treatment sequence to improve adherence and outcomes. Designed to be easy to implement, the new approach aims to empower primary care providers to act with confidence.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Ever wondered what it would be like to cross America primarily on dirt roads? Andy and Mercedes Lilienthal let us ride shotgun on their extraordinary Transamerica Trail adventure – a jaw-dropping 7,100-mile journey with over 3,100 miles on unpaved terrain, all completed in just 29 days.The couple's modified 2025 Subaru Crosstrek Wilderness proved remarkably capable, conquering elevations approaching 13,000 feet in Colorado and withstanding temperatures ranging from freezing to a sweltering 111°F in Moab. Their detailed walkthrough of the vehicle's modifications reveals the thoughtful preparation behind such an ambitious journey – from the Thule rooftop tent and ARB awning to the critical Primitive Racing skid plates that protected vital components on rough terrain.What makes their story particularly compelling isn't just the vehicle specs or challenging routes – it's how this journey provided them a completely different perspective on America. Despite both having previously visited all 50 states, experiencing the country from rural backroads allowed them to discover unfamiliar wildlife, connect with locals in remote areas, and witness aspects of American life rarely seen from interstate highways. Perhaps most fittingly, they completed this epic adventure on their 21st wedding anniversary, proving their relationship is as durable as their remarkably capable Subaru.We also feature Don Armstrong's comprehensive review of the 2025 Chevrolet Blazer EV, a sleek electric SUV with limousine-like comfort and impressive 615 horsepower performance. Don highlights its sharp exterior design, user-friendly 17-inch infotainment system, and competitive positioning in the premium electric SUV market at $44,600 for base models with the high-performance SS trim testing at $64,180.Subscribe to In Wheel Time for more fascinating automotive adventures, detailed vehicle reviews, and conversations with passionate car enthusiasts who push the boundaries of what's possible on four wheels.Be sure to subscribe for more In Wheel Time Car Talk!The Lupe' Tortilla RestaurantsLupe Tortilla in Katy, Texas Gulf Coast Auto ShieldPaint protection, tint, and more!Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.---- ----- Want more In Wheel Time car talk any time? In Wheel Time is now available on Audacy! Just go to Audacy.com/InWheelTime where ever you are.----- -----Be sure to subscribe on your favorite podcast provider for the next episode of In Wheel Time Podcast and check out our live multiplatform broadcast every Saturday, 10a - 12noonCT simulcasting on Audacy, YouTube, Facebook, Twitter, Twitch and InWheelTime.com.In Wheel Time Podcast can be heard on you mobile device from providers such as:Apple Podcasts, Amazon Music Podcast, Spotify, SiriusXM Podcast, iHeartRadio podcast, TuneIn + Alexa, Podcast Addict, Castro, Castbox, YouTube Podcast and more on your mobile device.Follow InWheelTime.com for the latest updates!Twitter: https://twitter.com/InWheelTimeInstagram: https://www.instagram.com/inwheeltime/https://www.youtube.com/inwheeltimehttps://www.Facebook.com/InWheelTimeFor more information about In Wheel Time Car Talk, email us at info@inwheeltime.comTags: In Wheel Time, automotive car talk show, car talk, Live car talk show, In Wheel Time Car Talk

Casella heads to Readercon, a Boston-based science fiction convention that’s unusually good at keeping the focus literary. This episode includes an interview with one of the conrunners, a discussion of translated SFF and the Translated Hugo Initiative, and a visit with a new romance bookstore in Cambridge. Some quick coffee reporting, as well. Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books. Please consider supporting ARB’s Patreon! Credits: Featuring interviews with: Rae Borman @ Readercon Riley @ Lovestruck Books Host: Jake Casella Brookins Music by Giselle Gabrielle Garcia Artwork by Rob Patterson Opening poem by Bhartṛhari, translated by John Brough Transcribers: Kate Dollarhyde and John WM Thompson   References: Rae Borman New England Finger Dancers Naomi Novik’s Scholomance Brandon Mull’s Fablehaven Katherine Rundell’s Impossible Creatures James Blish Joanna Russ’s The Female Man Benjamin Rosenbaum & our episode on Fire Logic Sunny Moraine & our episode on Pattern Recognition Beneath Ceaseless Skies, Clarkesworld, Strange Horizons Will McMahon NEA grant cuts and translated SF: 3% Podcast, Adam Morgan’s LARB article, and Strange Horizon’s reviews & podcast on the subject. Eden Kupermintz & our episode on The Silmarillion The Translated Hugo Initiative: translatedhugo.org Renay's "That's a Nice Review You've Got There" Michael Cisco Jon Stone’s The Monster At The End of This Book George Howell & Broadsheet coffee Chip Pons's Winging it With You Sarah McLean Omegaverse (do be careful where you look that up) The Ripped Bodice Grump & Sunshine Read My Lips Boston Harvard Coop Bookstore, Trident, Purple Couch Candlewick Press Ingram distributors Cat Sebastian's We Could Be So Good & Star Shipped Rachel Reid's The Shots You Take Adam Silvera  Sarah J. Maas Rebecca Yarros’s Fourth Wing S.T. Gibson’s Evocation & Ascencion Rina Kent, Navessa Allen Heather Bartos’s Quickies Emily Henry, Tessa Bailey, Sarah McLean, Kim Swizz Everina Maxwell’s Winter Orbit

Podcasts, reviews, interviews, essays, and more at the Ancillary Review of Books.Please consider supporting ARB's Patreon!Credits:Featuring interviews with:Rae Borman @ ReaderconRiley @ Lovestruck BooksHost: Jake Casella BrookinsMusic by Giselle Gabrielle GarciaArtwork by Rob PattersonOpening poem by Bhartṛhari, translated by John BroughTranscribers: Kate Dollarhyde and John WM ThompsonReferences:Rae BormanNew England Finger DancersNaomi Novik's ScholomanceBrandon Mull's FablehavenKatherine Rundell's Impossible CreaturesJames BlishJoanna Russ's The Female ManBenjamin Rosenbaum & our episode on Fire LogicSunny Moraine & our episode on Pattern RecognitionBeneath Ceaseless Skies, Clarkesworld, Strange HorizonsWill McMahonNEA grant cuts and translated SF: 3% Podcast, Adam Morgan's LARB article, and Strange Horizon's reviews & podcast on the subject.Eden Kupermintz & our episode on The SilmarillionThe Translated Hugo Initiative: translatedhugo.orgRenay's "That's a Nice Review You've Got There"Michael CiscoJon Stone's The Monster At The End of This BookGeorge Howell & Broadsheet coffeeChip Pons's Winging it With YouSarah McLeanOmegaverse (do be careful where you look that up)The Ripped BodiceGrump & SunshineRead My Lips BostonHarvard Coop Bookstore, Trident, Purple CouchCandlewick PressIngram distributorsCat Sebastian's We Could Be So Good & Star ShippedRachel Reid's The Shots You TakeAdam Silvera Sarah J. MaasRebecca Yarros's Fourth WingS.T. Gibson's Evocation & AscencionRina Kent, Navessa AllenHeather Bartos's QuickiesEmily Henry, Tessa Bailey, Sarah McLean, Kim SwizzEverina Maxwell's Winter Orbit

Hours after President Donald Trump appeared to take the temperature down with Fed Chair Jerome Powell, the White House on Friday resumed its attacks on the central bank chief and its headquarters renovation.~This Episode is Sponsored By Coinbase~ Buy $50 & Get $50 for getting started on Coinbase➜ https://bit.ly/CBARRONGuest: Evan AldoEvan Aldo Youtube Channel ➜ https://bit.ly/EvanAldo20% off Evan Aldo Course ➜ https://bit.ly/EvanCourse ➜  Use code "paulbarron"00:00 Intro00:17 Sponsor: Coinbase01:00 Trump x Powell showdown03:40 Most trade deals done by August 1st05:22 M2 Surge06:00 ETH analysis08:40 ETH all in moment10:50 Tom Lee: ETH benefits from lower rates12:12 Bitcoin analysis13:50 Solana analysis16:05 XRP analysis18:00 Will we see a bear market?18:45 Hedera analysis19:52 Polygon analysis22:14 $ARB or $AVAX?24:30 TRON on Wall Street25:45 Would exit BTC into ETH now?26:50 Outro#Crypto #xrp #Ethereum~Buy The Dip Altcoin Discounts

Join us for an action-packed episode of the Jeep Talk Show Roundtable!

Hey Jeepers, it's time for another epic Jeep Talk Show flagship episode!

Articles featured in this episode: "Eastern Michigan women's lacrosse team recognized at Board of Regents meeting" - Caleb Henderson "EMU's University Park pond serves as home for dozens of koi, even during winter" - Israel Shriki "Shakespeare in the Arb brings 'The Merry Wives of Windsor' to life this summer" - Allie Beecher "EMU's online vendor change & 6 things to know about textbooks before fall 2025" - Israel Shriki

THE LANCET 2003;362:772-776Background: Angiotensin converting enzyme inhibitors (ACEi) reduce mortality and morbidity in patients with systolic heart failure (see CONSENSUS and SOLVD trials). However, registry data showed that up to 20% of patients with systolic heart failure were not taking ACEi. One of the frequent causes for intolerance to ACEi is cough. Angiotensin converting enzyme inhibitors work by blocking the conversion of angiotensin I to angiotensin II, a key step in the renin–angiotensin–aldosterone system (RAAS). Angiotensin II receptor blockers were tolerated in patients with systolic heart failure who were intolerant to ACEi. However, data on long term effectives as an alternative to ACEi were lacking.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM)-Alternative trial sough to assess if the angiotensin-receptor blocker (ARB) candesartan, could improve outcomes in patients with systolic heart failure who are intolerant to ACEi.Patients: Eligible patients had left ventricular ejection fraction of 40% or less and NYHA class II, III or IV symptoms of at least 4 weeks duration. Patients had also to be intolerant to ACEi.Exclusion criteria were not provided in the main manuscript.Baseline characteristics: Patients were recruited from 618 centers in 26 countries. The trial randomized 2,028 patients – 1,013 randomized to receive candesartan and 1,015 to receive placebo.The average age of patients was 67 years and 68% were men. The average left ventricular ejection fraction was 30%. Cardiomyopathy was ischemic in 68% of the patients. The NYHA class was II in 48% of the patients, III in 49% and IV in 4%.Approximately 50% had hypertension, 27% had diabetes, 61% had prior myocardial infarction, 9% had stroke, 25% had atrial fibrillation and 14% were current smokers.At the time of enrollment, 85% were taking a diuretic, 46% were taking digoxin, 55% were taking beta-blockers and 24% were taking spironolactone.The most common reasons for ACEi intolerance were cough in 72% of the patients, hypotension in 13%, renal dysfunction in 12% and angioedema or anaphylaxis in 4%.Procedures: The trial was double-blinded. Patients were assigned in a 1:1 ratio to receive candesartan starting at 4 or 8mg once daily or placebo. The treatment was doubled every two weeks to a target dose of 32mg once daily.After randomization, follow up occurred at 2, 4, and 6 weeks, 6 months and every 4 months thereafter.Endpoints: The primary outcome was a composite of cardiovascular death or heart failure hospitalizations. All deaths were classified as cardiovascular unless there was a clear non-cardiac cause.Analysis was performed based on the intention-to-treat principle. The estimated sample size to have 80% power at 5% alpha was 2,000 patients. The sample size calculation assumed 18% relative risk reduction in the primary outcome with candesartan assuming a 15% annual event rate in the placebo arm.Results: The median follow up time was 34 months. The mean candesartan daily dose was 23mg at 6 months.Candesartan reduced the primary endpoint of cardiovascular death or heart failure hospitalizations (33.0% vs 40.0%, adjusted HR: 0.70, 95% CI: 0.60 – 0.81; p< 0.001). Candesartan reduced the individual components of the primary outcome - (21.6% vs 24.8%; p= 0.02) for cardiovascular death and (20.4% vs 28.2%; p< 0.001) for heart failure hospitalizations. All-cause death was also lower with candesartan (26.2% vs 29.2%, adjusted HR: 0.83, 95% CI: 0.70–0.99; p= 0.033). The number of patients who had any hospitalization as well as the total number of hospitalizations were numerically but not statistically significantly lower with candesartan (60.2% with candesartan vs 63.3%; p= 0.16) and (1,718 vs 1,835; p= 0.06).Candesartan was associated with more hypotension (3.7% vs 0.9%), more increase in creatinine (6.1% vs 2.7%) and more hyperkalemia (1.9% vs 0.3%). Angioedema occurred in three patients in the candesartan group and none in the placebo group. Cough occurred in two patients taking candesartan and four taking placebo.Authors reported no significant subgroup interactions, however, a corresponding graph was not provided.Conclusion: In patients with systolic heart failure who are intolerant to ACEi, candesartan reduced the primary composite outcome of cardiovascular death or heart failure hospitalizations with a number needed to treat of approximately of 14 patients over 34 months of follow up. Candesartan also reduced all-cause death with a number needed to treat of approximately 33 patients. Adverse events including hypotension, increase in creatinine and hyperkalemia were more common with candesartan.The reduction in the primary endpoint with candesartan was significant and offers an alternative for patients who are unable to tolerate ACEi. Of note, 72% of the patients enrolled in the trial were intolerant to ACEi due to cough. This trial did not include a head-to-head comparison between ARBs and ACEi, and therefore does not address which agent should be preferred as first-line therapy. Only 24% of participants were receiving spironolactone. The combination of ARBs with spironolactone, may increase the risk of adverse events, particularly hyperkalemia and kidney injury.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

In this episode, we discuss the diagnosis and treatment of resistant hypertension, including a newer endothelin receptor antagonist (ERA) called aprocitentan (Tryvio®). Key Concepts The diagnosis of true resistant hypertension is based on requiring more than 3 antihypertensives (ACE inhibitor or ARB + calcium channel blocker + diuretic) to achieve goal BP, ruling out inaccurate BP readings, and ensuring patient adherence to their antihypertensive therapy. Non-pharmacologic therapy (especially dietary sodium restriction), medication adherence, and lifestyle changes are critical to the treatment of resistant hypertension. The preferred 4th line option for most patients with resistant hypertension is spironolactone. After adding spironolactone, additional therapies are based on expert opinion and patient-specific factors. These additional therapies may include beta blockers, alpha-2 agonists, alpha-1 blockers, hydralazine, minoxidil, and aprocitentan. References Carey RM, Calhoun DA, Bakris GL, et al. Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association. Hypertension. 2018;72(5):e53-e90. doi:10.1161/HYP.0000000000000084 Mancia G, Kreutz R, Brunström M, et al. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023;41(12):1874-2071. doi:10.1097/HJH.0000000000003480

Irbesartan is an angiotensin II receptor blocker (ARB) used primarily for the management of hypertension and diabetic nephropathy in type 2 diabetes. It selectively inhibits the binding of angiotensin II to the AT1 receptor found in vascular smooth muscle and the adrenal gland. This blockade results in vasodilation, reduced aldosterone secretion, decreased sodium and water retention, and ultimately lower blood pressure. Irbesartan is administered orally, with a typical starting dose of 150 mg once daily, which may be increased to 300 mg depending on the patient's clinical response and tolerability. Adverse effects of irbesartan are generally mild but can include hyperkalemia and dizziness. Hypotension may occur, especially in volume-depleted individuals or those on diuretics. Routine monitoring of renal function and serum potassium is recommended, especially in patients with underlying kidney disease or those taking potassium-sparing agents or supplements. Irbesartan is contraindicated in pregnancy due to the risk of fetal toxicity and should be discontinued as soon as pregnancy is detected.