Podcasts about FFR

JACC Executive Associate Editor Karthik Murugiah, MD, FACC, speaks with author Jasmine M. Marquard, MD, PhD, on her study published in JACC and presented at EuroPCR. The discussion focuses on 10-year outcomes, including repeated events, of fractional flow reserve (FFR)-guided complete revascularization versus treatment of the infarct-related artery only in ST-segment elevation myocardial infarction. As the original trial, the primary outcome was a composite of all-cause mortality, recurrent myocardial infarction, or any revascularization. Complete revascularization reduced the risk of the primary outcome by 24%. Complete re-vascularization showed an absolute reduction of 13 events (-1 to 28 events) per 100 persons after 10 years. FFR-guided complete revascularization reduced future and repeated events after 10 years, primarily by reducing revascularization rates, without reducing myocardial infarctions or death.

My heart is literally on fire today…and not because of a workout —but because we're going deep on HEART HEALTH with one of the top preventative cardiologists in the country, Dr. Milind Parikh. This is personal for me. My dad died of a heart attack at 58. I've got the genetics. I've also got the drive to outlive it. And now, I've got the data AND treatments to potentially stave off the #1 Killer in America—heart attack. On today's IMPACT SHOW episode, Dr. Parikh walks us through what it means to be a preventative cardiologist, why most heart attacks are 100% preventable, and how A.I.-powered Coronary CT scans are revolutionizing modern medicine. This is what is now being called Medicine 3.0 — and friends, it's here. Here are some of the things we discuss: What is “preventative cardiology” and what exactly do you do? The 4 pillars of heart health and how you can improve each one of them. Why we have it wrong many times and WHY “normal” cholesterol doesn't guarantee a healthy heart. The difference between soft plaque vs. hard plaque (this is BIG!); which one is “good” and which one is “bad.” What exactly is a CT heart scan and what do you look for? How the software & technology in a Coronary CT scan with A.I. plaque analysis & FFR shows the difference between “soft plaque” and “hard plaque” and your true risk of having a heart attack. What causes plaque buildup in the heart? How does the A.I. fit into all of this and what is its role? The million dollar question: “Can you reverse plaque buildup and if so, HOW?” Why sleep apnea (often called the “Silent killer”) can ultimately stress your heart and ultimately cause a heart attack/death. The power of early detection of heart disease and how a Coronary CT scan with A.I. plaque analysis can help prevent a coronary episode. Supplements & new meds that may reverse plaque. This is interesting! Why you must start testing NOW— even if you “feel fine.” What's next in Medicine 3.0 and what is your role in this cutting-edge field? This is one of the most important episodes I've ever done. Again, it's something near & dear to my heart (pardon the pun). If you have a family history of heart disease OR you just want to maximize your health and prevent heart disease, this is a MUST LISTEN to episode. If you love LIFE and want to stave off coronary disease or a heart attack, DO NOT MISS THIS ONE…your LIFE may depend on it. LISTEN. SHARE. SAVE A LIFE. If this hits home, please share it with someone you care about. You just might save their life. Please SHARE it your Social Media and if it speaks to you, please also give us a 5-star rating and write us a review. You can do that at: IG: @ToddDurkin @drmparikh @imageone.sandiego FB: www.Facebook.com/ToddDurkinFQ10 CONNECT WITH DR. MILIND PARIKH: Learn more or book a scan www.ctheartscan.com Image One & The Cardiovascular Institute of San Diego Contact: (858)769-4833 o www.ctheartscan.com   #ToddDurkinImpactShow #HeartHealth #PreventativeCardiology #AIinMedicine #LiveInspired #TestDontGuess #Medicine3Point0 #MindsetMatters #Prevention #Health #Wellness #Longevity #EarlyDetection #Heart #Cardiac #HeartAttack #CTHeartScan #PlaqueAnalysis #HeartHealth #CAD Dr. Parikh is a cardiovascular disease specialist and dedicated preventative cardiologist passionate about protecting patients from the life-altering effects of heart disease. With a career rooted in evidence-based medicine and cutting-edge diagnostics, Dr. Parikh has made it his mission to identify cardiovascular risks early and intervene before heart attacks occur. His extensive training and multiple board certifications in cardiovascular disease, cardiac CT, echocardiography, and nuclear cardiology reflect his commitment to providing comprehensive, state-of-the-art care for his patients. Dr. Parikh has a unique approach to preventative cardiology, blending the latest advances in diagnostic techniques with a personalized and integrative treatment philosophy. Beyond his clinical work, Dr. Parikh is actively involved in clinical trials, exploring new frontiers in cardiovascular prevention and care. He serves as the current Director of Cardiac CT and Preventative Cardiology at Image ONE and Cardiovascular Institute of San Diego. Additionally, Dr. Parikh is a sought-after speaker, delivering engaging presentations to physicians and patients on various topics related to preventative cardiology. Passionate about education and collaboration, Dr. Parikh works closely with his patients to implement meaningful lifestyle changes, optimize treatments, and leverage emerging technologies to achieve lasting results.

The Mutant Idiot Show,All podcasts are from studios of FCCFREE RADIO and archived by John Miller . Dung and John were friends for years. Thats how we have all most 100 2 hour podcasts that were recorded in the John Miller Studios of FFR in San Francisco CaliforniaDung passed a few years ago and WWMG has rights to the recordings and to replay. We miss him a lot, he would give John advice when asked a question about running FFR but make John think he thought it up.The Mutant Idiotshow returns to FCCFreeRadio.com! Hosted by M. Dung a broadcasting vet of 30 years. The Idiot Show began in 1977 in Allendale, Mi. at student radio WSRX. Dung has worked in Detroit, Phoenix, San Francisco and San Jose. I left commercial radio in 1999, I now work at Intel and broadcast as a hobby, great to be part of the FCCFree family again!!All rights are owned by WayWacked Media Group.

Ep. 153 : Si Proches, Si Loin - 6 Nations Féminin - France vs Angleterre avec Amélie MahéC'est le week-end de clôture des 6 nations chez les filles ! Après une victoire un peu poussive chez les italiennes, nos bleues s'avançaient à Twickenham face à des anglaises ultra favorites pour enchaîner leur ... 7e victoire d'affilée dans ce Tournoi de Six Nations. Auteures d'une première demi-heure catastrophique, les françaises ont malheureusement couru après le score et sont venues échouer à un tout petit point de la victoire et du grand chelem... Frustrant !! Elles devront tirer des enseignements de ce match pour espérer bousculer la hiérarchie lors de la Coupe du Monde de Rugby Féminin 2025... en Angleterre ! Côté garçons c'est vers le bas du Top 14 qu'étaient braqués les projecteurs ce week-end. Avec sa formidable victoire bonifiée sur Toulon, Vannes s'est donné le droit de rêver et c'est le Stade Français, étrillé par son voisin du Racing qui fait des cauchemars et devra s'imposer à Perpignan pour espérer éviter une incroyable dégringolade en Pro d2...Et pour le même prix, vous aurez droit au coup de gueule d'Amélie en fin d'épisode, on la comprend ! Bon mercredi avec le pack !Bonne écoute!Voici l'autre podcast de TK --> L'Année Sobre, un an sans alcool ! https://podcast.ausha.co/un-peu-plus-leger/playlist/l-annee-sobre-saison-3-de-un-peu-plus-leger-podcastHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Το ACC 2025 μας έφερε νέες κλινικές μελέτες και κάθε μία είχε τη δική της ιστορία να πει:WARRIOR: Η καρδιαγγειακή πρόληψη στις γυναίκες εξελίσσεται. Πως θα χειριζόσασταν γυναίκες με μη αποφρακτική στεφανιαία νόσο (INOCA);RIVAWAR: Rivaroxaban εναντίον warfarin σε θρόμβο αριστερής κοιλίας. SOUL: Η εξέλιξη της σεμαγλουτίδης σε απο του στόματος μορφή υπόσχεται καλά αποτελέσματαSTRIDE: Ποιος ο ρόλος της σεμαγλουτίδης σε ασθενείς με διαβήτη και περιφερική αγγειοπάθεια;DAPA-TAVI: Η νταπαγλιφλοζίνη μετά από TAVI δείχνει καρδιοπροστατευτικά οφέλη σε ασθενείς με καρδιακή ανεπάρκεια ZENITH: Sotatercept σε σοβαρή πνευμονική αρτηριακή υπέρταση, μια ακόμα νίκη.FAME 3: Όταν η φυσιολογία μετράει – η FFR-guided PCI vs CABG σε πολυαγγειακή νόσο.SINGLE SHOT CHAMPION: PFA vs cryoballoon σε ασθενείς με παροξυσμική κολπική μαρμαρυγή, ποιο είναι το μέλλον;

Ep. 152 : Honneur aux dames ! 6 Nations Féminin et EPCR Champions Cup avec Amélie MahéUne fois n'est pas coutume nous parlerons beaucoup de rugby féminin aujourd'hui ! Très bien accompagnés pour cela par notre pote Amélie Mahé, une épatante joueuse qui pousse la passion familiale très loin comme vous l'entendrez, chapeau à elle ! L'équipe de France a tout gagné pour le moment dans le Tournoi de Six Nations Féminin mais s'avance vers sa bête noire vêtue de blanc (les Anglaises) qu'elle n'a plus battue depuis trop longtemps… les Bleues sauront-elles le faire ?Parce qu'il en faut pour tous les goûts nous dirons quelques mots des coupes d'Europe des garçons : quelles demi-finales à venir pour le EPCR Champions Cup !! Le tenant Stade Toulousain et l'ogre du Leinster laisseront-ils un peu d'espoir aux formidables UBB et Saints de Northampton ? A ne pas rater en tous cas ! On a même évoqué le Racing et sa victoire au Connacht qui pourrait bien sauver la saison des ciel et blanc avec une victoire potentielle dans le ECPR Challenge Cup, mais attention aux loups des LOU Rugby …Bref on s'est régalés ! Bonne écoute!Voici l'autre podcast de TK --> L'Année Sobre, un an sans alcool ! https://podcast.ausha.co/un-peu-plus-leger/playlist/l-annee-sobre-saison-3-de-un-peu-plus-leger-podcastHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Mirza Umair Khalid, MD, social media editor of JACC: Cardiovascular Interventions, and William F. Fearon, MD, FACC, discuss analysis from FAME III trial comparing outcomes of CABG vs FFR-guided multivessel PCI for patients in ACS versus CCS.

The Mutant Idiot Show,All podcasts are from studios of FCCFREE RADIO and archived by John Miller . Dung and John were friends for years. Thats how we have all most 100 2 hour podcasts that were recorded in the John Miller Studios of FFR in San Francisco CaliforniaDung passed a few years ago and WWMG has rights to the recordings and to replay. We miss him a lot, he would give John advice when asked a question about running FFR but make John think he thought it up.The Mutant Idiotshow returns to FCCFreeRadio.com! Hosted by M. Dung a broadcasting vet of 30 years. The Idiot Show began in 1977 in Allendale, Mi. at student radio WSRX. Dung has worked in Detroit, Phoenix, San Francisco and San Jose. I left commercial radio in 1999, I now work at Intel and broadcast as a hobby, great to be part of the FCCFree family again!!All rights are owned by WayWacked Media Group.

Ep. 150: 6 Nations 2025 France / Ecosse : Les Sentiers de la Gloire ! Avec Jonathan BestClap de fin pour les 6 Nations 2025 ! Donc voila notre épisode récap avec un special guest : Jonathan Best, ancien 2ème/3ème ligne de Grenoble et Béziers! En route alors vers l'Italie, où les Irlandais, défaits par les Bleus il y a 8 jours et groggy comme jamais, sont venus s'imposer sur le fil face à des Italiens qui ont laissé filé un match qui leur tendait les bras : qu'il est dur l'apprentissage du (très) haut niveau ! A Cardiff les gallois qui avaient montré un peu de mieux espéraient se relancer face aux anglais. Malheureusement il n'en fut rien : dans une orgie de jeu face à des diables rouges qui méritaient leur surnom de poireau et n'avaient pas l'ombre d'une solution, le XV de la rose a enfoncé son hôte et pris date avec sa nouvelle génération qui promet!A Paris, enfin, on attendait un festival de rugby pour clore en beauté ce tournoi quelque peu gâché par la défaite rageante de Twickenham. Malgré l'absence de Super-Dupont, quelques scories et en dépit des intentions de ce diable de Darcy Graham, les bleus, dans le sillage d'un Moefana de gala, ont "fait le job" et remporté le tournoi. Ils ont pris sans trop trembler la mesure des hommes du chardon, et donné RDV à leurs fans pour les deux années à venir. Vers la gloire ? En Bonus : Notre XV du Tournoi de 6 Nations! Bon mercredi avec le pack !Voici l'autre podcast de TK --> L'Année Sobre, un an sans alcool ! https://podcast.ausha.co/un-peu-plus-leger/playlist/l-annee-sobre-saison-3-de-un-peu-plus-leger-podcastHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

News, Le COACH du Stade Français veut partir ! - Le 6 Nations Féminin - Victoire des Bleuets ! - La coupe du monde U20 (Poules, lieu) - Le résultat du REC 2025 et qualif RWC27 - NTK et Alldritt en Nouvelle-Zélande en Juillet ?! - Un nouveau président à la LNR - L'avion du 6 Nations (Italie v Irlande / Galles v Angleterre) - Retour sur France v Ecosse - Bilan du 6 Nations côté Français - Bilan global du 6 Nations - Nos XV de ce 6 Nations 2025Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Ep. 149: 6 Nations 2025 Irlande / France : Aux (L)Armes Citoyens Le rendez-vous à Dublin était pris pour les Bleus (surtout avec eux mêmes!!) dans ce match au sommet ! Il fallait à la fois barrer la route du Grand Chelem aux hommes du trèfle et aussi prendre une revanche sur l'humiliation vécue à Marseille l'an dernier. D'abord intraitables en défense puis inspirés et impitoyables en attaque face à des Irlandais totalement dépassés, les Bleus (qui ont malheureusement perdu Dupont au feu), se sont forgé des convictions et ont gagné leurs galons de guerriers sur une pelouse qui a pourtant vu tant de braves finir le genou en terre. Un match référence !!A Murrayfield, les Ecossais ont assommé des Gallois trop tendres quoique vaillants jusqu'au bout. Le cauchemar se poursuit pour les diables rouges qui ont pourtant laissé voir quelques raisons d'espérer, mais leurs adversaires du jour étaient au dessus ! Enfin dans un Twickenham aux airs de printemps, les italiens ont subi la loi des anglais guidés par un Fin Smith aux allures de taulier et un Freeman qui n'en finit pas d'épater dans un collectif en construction. Rendez vous le WE prochain pour l'épilogue de ce tournoi en espérant une victoire bonifiée des bleus synonyme de trophée pour eux ! Bon mercredi avec le pack !!Voici l'autre podcast de TK --> L'Année Sobre, un an sans alcool ! https://podcast.ausha.co/un-peu-plus-leger/playlist/l-annee-sobre-saison-3-de-un-peu-plus-leger-podcastHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

On Monday's Rugby Daily, Richie McCormack brings you the latest on the health of an Ireland squad still licking their collective wounds after Saturday's defeat to France. FFR president Florian Grill seethes over their treatment at the hands of match officials. England's Ollie Lawrence is now a doubt for the Lions tour this summer. And Richie has the latest on Rabah Slimani's status as a Leinster player.

On Monday's Rugby Daily, Richie McCormack brings you the latest on the health of an Ireland squad still licking their collective wounds after Saturday's defeat to France. FFR president Florian Grill seethes over their treatment at the hands of match officials. England's Ollie Lawrence is now a doubt for the Lions tour this summer. And Richie has the latest on Rabah Slimani's status as a Leinster player.

Les U20 match fou en Irlande ! - Les nouveaux pour préparer l'Ecosse - Grill et Galthié montrent les dents ! (arbitrage) - La ProD2 - L'avion du 6 Nations - J4 - Débrief IRLANDE 27-42 FRANCEHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

N Engl J Med 2024;390:1481-1492Background: In patients with ST-elevation myocardial infarction (STEMI), opening the culprit artery improves outcomes. Nearly half of STEMI patients have disease in other coronary arteries. Whether revascularizing these non-culprit arteries improves outcomes remained uncertain. The PRAMI trial showed improvement in outcomes with complete revascularization but was relatively small, included 465 patients, and did not require the use of fractional flow reserve (FFR).Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The FFR-Guidance for Complete Nonculprit Revascularization (FULL REVASC) trial sought to assess if FFR-guided completed revascularization improves outcomes compared to culprit-only percutaneous coronary intervention (PCI).The COMPLETE trial was not published by the time the FULL REVASC trial started enrolling patients.Patients: Eligible patients had STEMI and were undergoing PCI or had high risk NSETMI undergoing urgent PCI. High risk NSTEMI included patients with dynamic ST–T-wave changes, ongoing chest pain, acute heart failure, hemodynamic instability independent of electrocardiographic changes, or life-threatening ventricular arrhythmias.Eligible patients had to have multivessel coronary artery disease, defined as one or more lesions in a nonculprit artery with a diameter of ≥ 2.5 mm and a visually graded stenosis of 50 - 99%.Patients were excluded if they had previous CABG, left main disease or cardiogenic shock.Baseline characteristics: The trial randomized 1,542 patients – 778 randomized to culprit-only PCI and 764 randomized to complete revascularization. Patients were recruited from 32 centers in 7 countries.Approximately 91% of the patients had STEMI and 9% had high risk NSTEMI.The average age of patients was 65 years and 76% were men. Approximately 51% had hypertension, 16% had diabetes, 23% were on treatment for hyperlipidemia, 8% had prior myocardial infarction, and 35% were current smokers.The number of residual coronary arteries with stenosis of 50-99% was 1 in 72% of the patients and 2 or more in the rest.Procedures: Patients were randomly assigned in a 1:1 ratio to undergo culprit-only PCI or FFR-guide complete revascularization. The study was open label.Patients in the culprit-PCI only group did not receive further revascularization during the index hospitalization. Patients in the FFR-guided complete revascularization could receive further revascularization during the index procedure or during the index hospitalization. PCI of non-culprit lesion was recommended if FFR was 0.80 or less.Endpoints: The primary outcome was a composite of death from any cause, myocardial infarction, or unplanned revascularization. The main secondary outcomes were a composite of death from any cause or myocardial infarction and unplanned revascularizationAnalysis was performed based on the intention-to-treat principle. The estimated sample size to achieve 80% with a two-sided alpha of 0.05 was 4,052 patients. This sample size would detect 0.75 risk ratio for the composite outcome of death or myocardial infarction at 1-year assuming 9.9% event rate in the culprit-only PCI. After the publication of the COMPLETE trial, the trial was stopped early due to ethical and feasibility concerns. Consequently, the original key secondary outcome (death from any cause, myocardial infarction, or unplanned revascularization) became the new primary outcome, and events after 1 year of follow-up were included in the primary analysis.Results: The trial was stopped after randomizing 38.1% of the original sample size. Among the patients assigned to the FFR-guided complete-revascularization arm, the procedure was followed in 95.9% of the patients, and among these patients, 17.9% underwent FFR-guided complete revascularization of non-culprit lesions during the primary PCI and the rest during the index hospitalization. Among the patients assigned to culprit-only arm, the assigned strategy was followed in 99.6% of the patients. The median follow-up time was 4.8 years.FFR was 0.8 or less in 392 (47.3%) of non-culprit vessels assessed, and PCI was performed in 369 (94.1%) of these vessels. In total, PCI was performed in 18.8% of the total non-culprit vessels. The average number of stents during the index hospitalization was 1 in the culprit-only PCI group and 2 in the complete revascularization group.The primary composite outcome was not significantly different between both treatment groups (19.0% with complete-revascularization vs 20.4% with culprit-only PCI, HR: 0.93, 95% CI: 0.74 - 1.17; p= 0.53). There were also no significant differences in composite endpoint of death from any cause or myocardial infarction (16.5% with complete revascularization vs 15.3% with culprit-only PCI) or unplanned revascularization (9.2% with complete revascularization vs 11.7% with culprit-only PCI).Stent thrombosis and stent restenosis were significantly more frequent in the complete revascularization arm (2.5% vs 0.9%, HR: 2.80, 95% CI: 1.18 – 6.67) and (4.2% vs 2.3%, HR: 1.84, 95% CI: 1.03 – 3.28), respectively.Baseline risk or coronary anatomy did not significantly affect subgroup interactions for the primary outcome.Conclusion: In patients with STEMI or high risk NSTEMI, FFR-guided complete revascularization compared to culprit-only PCI, did not improve the outcomes of death from any cause, myocardial infarction, or unplanned revascularization, over a median follow up time of 4.8 years. Complete revascularization resulted in more stent thrombosis and stent restenosis.The study lost some statistical power by stopping early, resulting in a final power of 74%. We disagree with the authors' decision to halt the trial prematurely based on the findings of the COMPLETE trial. COMPLETE was the first large trial to demonstrate a benefit in hard outcomes when revascularizing stable plaques, and its results warrant further confirmation. Furthermore, COMPLETE used different strategy as FFR was not required.Note to readers: Power measures the study's ability to avoid a Type II error (false negative) and it equals 1 - β with β being the probability of a Type II error. In other words, power represents the probability of correctly rejecting the null hypothesis (H₀) when the alternative hypothesis (H₁) is true. Most clinical trials aim for 80% or 90% power. For example, a study with 80% power has a 20% risk of failing to detect a real effect.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

N Engl J Med 2019;381:1411-1421Background Percutaneous coronary intervention (PCI) had been clearly established as the standard of care for ST elevation myocardial infarction. Yet many patients taken for PCI have multiple lesions in addition to the culprit. The benefit of routinely treating additional significant lesions has been unclear, with previous smaller trials showing reductions in composite outcomes primarily driven by reduced revascularization rates.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The COMPLETE (Complete vs Culprit-Only Revascularization Strategies to Treat Multivessel Disease after Early PCI for STEMI) trial investigated whether performing percutaneous coronary intervention (PCI) on non-culprit lesions reduces cardiovascular risk in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease.Patients The trial enrolled 4,041 patients from 140 centers in 31 countries between February 2013 and March 2017. Eligible patients had STEMI with successful culprit-lesion PCI and at least one non-culprit coronary artery lesion with ≥70% stenosis (or 50-69% stenosis with FFR ≤0.80) in a vessel ≥2.5mm in diameter. Patients were randomized within 72 hours after successful culprit-lesion PCI. Exclusion criteria included planned surgical revascularization and previous coronary bypass surgery.Baseline Characteristics The mean age was approximately 62 years, with about 80% being male. Approximately 19% had diabetes, 8% had previous MI, and 7% had previous PCI. Over 90% of patients underwent primary PCI (vs. pharmacoinvasive or rescue PCI), with 80% using radial access.The groups were well-balanced, with similar SYNTAX scores at baseline and similar culprit and non-culprit lesion characteristics. About 76% had one residual diseased vessel and 24% had two or more. Guideline directed medical therapy was robust and balanced, including more than 99% on dual antiplatelet therapy, 98% on statins, 88% on beta blocker, and 85% on ACEi or ARB.In patients in the complete revascularization group designated for non-culprit PCI during index hospitalization, the mean time to PCI was 1 day. In the group designated for non-culprit PCI after discharge, the mean time was 23 days.Trial procedures Patients were randomized to complete revascularization (n=2,016) or culprit-lesion-only PCI (n=2,025). In the complete revascularization group, investigators specified before randomization whether non-culprit PCI would occur during index hospitalization or after discharge (within 45 days).Everolimus-eluting stents were recommended for all procedures. Both groups received guideline-based medical therapy including dual antiplatelet therapy with aspirin and ticagrelor for at least one year.Endpoints The first coprimary outcome was cardiovascular death or new myocardial infarction. The second coprimary outcome was cardiovascular death, myocardial infarction, or ischemia-driven revascularization. Secondary outcomes included individual components of the composite outcomes, all-cause mortality, and safety outcomes like major bleeding, stroke, and stent thrombosis.Trialists estimated that a sample of 4000 patients would give 80% power to detect a 22% lower risk of the composite of cardiovascular death or myocardial infarction in the complete-revascularization group than in the culprit-lesion-only PCI group, assuming an event rate of 5% per year in the culprit-lesion-only PCI group. The first coprimary outcome was tested at a P value of 0.045 and the second at a P value of 0.0119.The co-primary endpoints were analyzed according to the time to first event approach. Confidence intervals for secondary and exploratory efficacy outcomes were not adjusted for multiple comparisons, and therefore inferences drawn from these intervals may not be reproducible.Results Over a median follow-up of 36.2 months, the first coprimary outcome occurred in 7.8% of the complete-revascularization group versus 10.5% of the culprit-lesion-only group (hazard ratio 0.74, 95% CI: 0.60-0.91; p= 0.004). Benefit was driven by reduced myocardial infarction rates (5.4% vs 7.9%) while cardiovascular death rates were similar (2.9% vs 3.2%).The second coprimary outcome was also reduced with complete revascularization (8.9% versus 16.7%, HR: 0.51, 95% CI: 0.43-0.61; p

Abdullah Al-Abcha, MD, social media editor of JACC: Cardiovascular Interventions, and Matthias Götberg, MD, PhD, discuss a recently published manuscript reporting the long-term clinical outcomes after IFR vs. FFR guided coronary revascularization— Insights from SWEDEHEART.

On Monday's Rugby Daily, Richie McCormack brings you news of two players moving to IRFU central contracts in the summer. There's an update on the health of the squad ahead of Saturday's crunch with France. The FFR have made contact with World Rugby over the discrepancies in the bans of Garry Ringrose and Romain Ntamack. And could Ronan O'Gara be given a new voice in the La Rochelle coaches room?

On Monday's Rugby Daily, Richie McCormack brings you news of two players moving to IRFU central contracts in the summer. There's an update on the health of the squad ahead of Saturday's crunch with France. The FFR have made contact with World Rugby over the discrepancies in the bans of Garry Ringrose and Romain Ntamack. And could Ronan O'Gara be given a new voice in the La Rochelle coaches room?

Les News, les demis du REC - Ma'a Nonu de retour à Toulon - Pro D2, les résultats - L'affaire Ringrose - Le BUS du TOP14 - J18 - Preview IRLANDE v FRANCEHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

The treatment of asymptomatic aortic stenosis, the move to composite endpoints in trials, IFR vs FFR and high-frequency low tidal volume ventilation for AF ablation are the topics John Mandrola, MD, discusses in today's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Aortic valve intervention for Asymptomatic AS Lindman editorial https://jamanetwork.com/journals/jamacardiology/fullarticle/2829881 Trends https://pmc.ncbi.nlm.nih.gov/articles/PMC11308430/ Podcast EARLY TAVR Nov 8, 2024 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1001865 Faith Healing and Subtraction Anxiety https://www.ahajournals.org/doi/10.1161/circoutcomes.118.004665 Early TAVR trial https://www.nejm.org/doi/10.1056/NEJMoa2405880 EVOLVED https://jamanetwork.com/journals/jama/fullarticle/2825540 AVATAR https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057639 II Trial Endpoints Shepshelovich https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2830023 Brown meta-analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785560 III IFR vs FFR—a debate b/w RCTs and observational data 5-year DEFINE https://jamanetwork.com/journals/jamacardiology/fullarticle/2824470 5-year SwedeHeart IFR https://doi.org/10.1016/j.jacc.2021.12.030 Eftekhari meta-analysis https://doi.org/10.1093/eurheartj/ehad582 Gotberg SWEDEHEART Registry https://doi.org/10.1016/j.jcin.2024.12.003 Editorial of SWEDEHEART-Registry https://doi.org/10.1016/j.jcin.2024.12.014 IV High-frequency low-tidal-volume ventilation for AF ablation Osorio et al https://doi.org/10.1016/j.hrthm.2024.07.094 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Ep. 148: 6 Nations 2025 Italie / France : Des Promesses à Tenir ! Encore une belle journée de 6 Nations ponctuée à Rome par un festival offensif des Français qui ont brutalement renvoyé les Italiens à leurs doutes ! Avec 73 points marqués les Bleus ont assommé la planète rugby mais n'ont pas éloigné tous les doutes portés par quelques largesses défensives malvenues. Seule une victoire à Dublin mettrait un terme à ce (léger) goût d'inachevé !La veille les Anglais plus vaillants et ennuyeux que jamais continuaient de piocher dans la hotte du Père Noël qui cette fois était Ecossais : avec un zéro sur trois aux transformations et une défaite d'un tout petit point malgré 3 essais à 1, c'est Fin Russel qui aurait mérité une jolie barbe blanche ! Plus tôt à Cardiff, les Irlandais avaient eu toutes les peines du monde à venir à bout de Gallois enfin retrouvés et malheureux de céder en fin de match face à la furia de Bundee Aki et la force d'un collectif très efficace En bonus, nous parlons aussi des Lions Britanniques et de leur future tournée en Australie. Rdv dans deux semaines pour un sommet aux allures de finale avant l'heure à Dublin où le XV de France combattra Irlande pour empêcher les diables verts de foncer vers le Grand Chelem !! Bon mercredi avec le pack !!Voici l'autre podcast de TK --> L'Année Sobre, un an sans alcool ! https://podcast.ausha.co/un-peu-plus-leger/playlist/l-annee-sobre-saison-3-de-un-peu-plus-leger-podcastHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Les News, les demis du REC - JOSEPH RUIZ débarque à l'improviste pour parler du Stade Français ! - 7s tournoi de Vancouver - Pro D2, les résultats - Le 6 Nations U20 - Rumeur Gailleton à La Rochelle - Le BUS du TOP14 - J17 - L'info qui tombe des joueurs protégé par le XV de France - Retour sur le 6 Nations - J3 - Analyse ITALIE 24 - 73 FRANCEHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Damian Penaud OUT ! - Rugby 25, nos avis - Le RETOUR des championnats du SUD (MLR, Super Rugby,...) - Le GROS PLANNING RUGBY du weekend - La ProD2 - On apprend en live Jalibert aussi écarté - Le Rugby Europe Championship 2025 (Qualif RWC27) - Retour sur l'arbitrage français et le plan de performance - Le BUS du TOP14 - J16 - XV de FRANCE, du changement avant l'ITALIE !Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Ep. 147: 6 Nations 2025 Angleterre/France : Les Pieds dans le TapisC'est à Rome que débutait cette 2ème journée du 6 nations… par une nouvelle défaite pour les Gallois qui ont subi la loi d'une squadra azzura d'Italie en quête de confirmation et qui ne s'est pas privée d'enfoncer un peu plus les diables rouges, pour qui la descente aux enfers continue!A Twickenham tout un peuple rêvait de revanche après l'historique déculottée de 2023, et les Bleus espéraient la passe de quatre… Las ! Ils se sont lamentablement pris les crampons dans le gazon anglais ! La justesse technique, la force collective et… la chance, avaient déserté le camp tricolore. Les anglais, qui n'en demandaient pas tant, n'ont eu qu'à piocher dans la hotte du Père Noël tout de bleu vêtu pour gagner un match qu'ils auraient dû perdre 100 fois !Enfin à Murrayfield, les intraitables petits hommes verts ont écoeuré les écossais du chardon qui n'ont pas démérité mais ont simplement subi la loi du plus fort. Lancés vers un grand chelem qui leur tend désormais les bras, les irlandais n'en finissent plus d'affirmer leur suprématie européenne… A moins que les français n'en décident autrement dans trois semaines ??Bon mercredi, et bon Six Nations avec le pack !!Voici le lien pour l'autre podcast de TK, sur un sujet santé --> L'Année Sobre, un an sans alcool ! https://podcast.ausha.co/un-peu-plus-leger/playlist/l-annee-sobre-saison-3-de-un-peu-plus-leger-podcastHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Les News du rugby (U20, REC 2025, Pro D2, Groupe France) - L'AVION du 6 Nations (Retour sur ITAvGAL et ECOvIRL) - Retour sur ANGLETERRE 26-25 FRANCEHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Ep. 145: 6 Nations 2025 - Jusqu'ici, tout va bien !! + NéoHéros Raphaël PoulainWE d'ouverture conforme aux pronostics du Pack !! Avec un récital et un festival d'essais, les Bleus de France ont renversé un poireau gallois déjà bien pâle avant même cette 13ème défaite de rang ! Si le match a confirmé la forme française, elle a aussi malheureusement enfoncé les Gallois plus loin encore dans leurs doutes avec un zéro pointé et un gros mal de tête persistant pour Warren Gatland. En Ecosse, les formidables Chardons portés par un Huw Jones intenable ont fait respecter la hiérarchie et pris leur revanche sur de très valeureux italiens, qui n'en finissent pas d'étonner. L'Italie aura l'opportunité de vaincre les Gallois le WE prochain dans un match qui s'annonce déjà comme celui de la cuillère de bois! Enfin quel match en Irlande !! Les Anglais survoltés et costauds en diable ont d'abord fait douter un trèfle qui paraissait emprunté, mais qui a laissé passer l'orage et renversé la table pour conserver son leadership grâce notamment aux inévitables James Lowe et Bundee Aki, des vrais seigneurs dans la bataille ! Et maintenant ? RDV la semaine prochaine pour un Crunch plus indécis que jamais, revanche pour la Rose battue deux fois dont une fessée mémorable à Twickenham, ou confirmation pour les Bleus ?? A VOIR ABSOLUMENT ! En bonus, nous sommes heureux de recevoir Raphaël Poulain ancien ailier du Stade Français, devenu porte-parole pour un sujet sérieux dans notre sport: la santé mentale des joueurs (grands et petits). Il nous parlera de son association NéoHéros et de leur partenariat avec la LNR, Ligue Nationale de Rugby. Voici aussi notre épisode avec Raphaël POULAIN il y a 1 ans! https://smartlink.ausha.co/pack-de-potes-rugby-podcast/raphael-poulain Bon mercredi avec le pack !Voici le lien pour l'autre podcast de TK, sur un sujet santé --> L'Année Sobre, un an sans alcool ! https://podcast.ausha.co/un-peu-plus-leger/playlist/l-annee-sobre-saison-3-de-un-peu-plus-leger-podcastHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

On today's packed episode of FFR, we discuss the biggest risers and other notes from the 2025 Senior Bowl, go over the AFC North in the 2024 Season, and breakdown a number of Ohio State Prospects.Support the Show: https://buymeacoffee.com/fantasyforrealTIMELINE || Senior Bowl Risers — 1:50 || Senior Bowl (Other) — 7:20 || Deeper Dives || Emeka Egbuka — 15:30 || TreVeyon Henderson — 25:20 || Quinshon Judkins — 37:20 || Will Howard — 46:00 || NFL DIVISION REVIEW — 58:15 || Browns — 59:25 || Bengals — 69:10 || Steelers — 74:45 || Ravens — 86:45 || End Notes — 95:35Video Links: Egbuka — https://www.youtube.com/watch?v=OEPyN9DW7qk ; Henderson — https://www.youtube.com/watch?v=1wVahUg-qMA + https://www.youtube.com/watch?v=KO3Tk5oGRnk ; Judkins & Howard — https://www.youtube.com/watch?v=QgeJ9Sgyz8Q  Get full access to C.J.'s Substack at cjfreel.substack.com/subscribe

Point sur la FANTASY 6 Nations - Affaire Jaminet x Stade Toulousain - Hugo Reus au MHR - Le 6 Nations U20 - Collazo au Racing92 - Le Rugby Europe Championship - L'Avion du 6 Nations - Ecosse v Italie - Irlande v Angleterre - Info Compo FRA - France v GallesHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

A.C. and Kat are joined by director Sav Rodgers to discuss his documentary feature debut, Chasing Chasing Amy, and the complicated legacy of its subject matter, Kevin Smith's 1997 film Chasing Amy. Sav shares about the arduous process of becoming the central story in his own doc, and examining his relationship to the movie that saved his life as a young queer person. We explore how we take our various fandoms seriously, and what it means to blend loving a piece of media with making that love the focus of our work and/or our identities.Discussed in this episode:Sav's film CHASING CHASING AMY, which is also available on KanopyChasing Amyaction figuresFind Sav:bsky.app/profile/savrodgers.bsky.socialletterboxd.com/savrodgersFind Kat:letterboxd.com/katexmachinabsky.app/profile/katexmachina.bsky.socialtwitter.com/kat_ex_machinaFind AC:letterboxd.com/aclambertyinstagram.com/aclambertyFind Us:Support us on PatreonOur WebsiteSubscribe to FFR on Apple PodcastsTwitterInstagramLetterboxdNEW: bsky.app/profile/femfreq.bsky.social

Ep. 145: Tournoi des 6 Nations Preview 2025 Rendez-vous de rentrée pour le Pack qui reprend ses bonnes habitudes ! A l'aube d'un Tournoi des 6 Nations très indécis, nous passons en revue les forces en présence : qui pourra déloger les Irlandais tenants du titre et toujours impressionnants ? Les Bleus pour confirmer une tournée d'automne encourageante, ou des britanniques fatigués de la suprématie du trèfle ? A moins que les Italiens pour une première ne raflent la mise … Premier RDV ce vendredi pour l'ouverture avec les Gallois en danger à Paris ! Bon mercredi avec le Pack !Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

La FANTASY 6 Nations sur Le Ptit BURO - News - Les blessés du XV de France - La Liste des bleus et la Compo contre le Pays de Galles - Est-ce que 42 c'est trop ? - Sevens, l'étape de Perth - La ProD2 - J18 - Le BUS du TOP14 - J15- La Preview du 6 Nations 2025 - Des détails dans les nouvelles règles - L'ITALIE - Le PAYS de GALLES - L'IRLANDE - L'ECOSSE - L'ANGLETERRE - LA FRANCEHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Etat des lieux sur les blessures XV de France - Grosse perte pour l'Ecosse - Rugby Europe Championship, le REC (Géorgie, Roumanie, Portugal...) - Ce weekend c'est Sevens ! - Une histoire folle en Angleterre - L'interview de Fabien Galthié dans le Midol - La liste des 42 du XV de France - Un point rapide sur la Challenge Cup - Le BUS de la Champion's Cup - J4Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

N Engl J Med 2009;360:213-24Lancet 2015;386:1853-60Background: Fractional flow reserve (FFR) is a measure of the physiologic significance of a coronary stenosis that is defined as the ratio of maximal blood flow in a stenotic artery to normal maximal flow. It is measured during coronary angiography by calculating the ratio of distal coronary pressure measured with a coronary pressure guidewire to aortic pressure measured simultaneously with the guiding catheter. FFR in a normal coronary artery equals 1.0 whereas a value 90% and is similar to information obtained with stress imaging studies.For patients with multivessel coronary disease, it can be a challenge in the cath lab to differentiate between blockages causing ischemia and those that are not and this may be especially challenging when patients have not undergone stress imaging prior (e.g., patients presenting with acute coronary syndromes without ST segment elevation). The FAME trial sought to test the hypothesis that revascularization guided by FFR would be superior to revascularization guided by angiography alone in a broad cohort of patients with multivessel disease in whom revascularization with PCI was indicated.Patients: Patients with multivessel CAD of at least 50% of the vessel diameter in at least 2 of the 3 major epicardial coronary arteries in whom PCI was indicated. Patients with a STEMI could be included if the infarction occurred at least 5 days before PCI. Patients with a NSTEMI could be included earlier than 5 days. Patients who had undergone previous PCI could be included.Patients were excluded if they had left main coronary disease, previous CABG, cardiogenic shock, extremely tortuous or calcified coronary arteries, a life expectancy less than 2 years, a contraindication to the placement of drug-eluting stents, or if patients were pregnant.Baseline characteristics: Information is not provided on patients screened to enrolled. The average age of patients was 64.5 years and approximately three quarters were men. It is not clear from the main manuscript how many patients presented with acute MI's. It appears that approximately one third of patients presented with unstable angina and about half of these patients had dynamic ECG changes. More than half of patients in the trial had class 2 angina or below. Approximately 25% of patients had diabetes and over 60% had hypertension. The average EF was 57%.The mean number of lesions per patient was 2.8. About 40% of blockages were estimated to be in the 50-70% range, another 40% were in the 71-90% range, 15% were 91-99% narrowed and 3% were chronic total occlusions. The minimal luminal diameter was 1.0 mm, mean reference vessel diameter was 2.5 mm, mean lesion length was 12.5 mm and the SYNTAX score was 14.5.Procedures: Patients were randomized after they were found to have multivessel disease, meeting the study criteria, and were thought to require PCI. Patients assigned to angiography-guided PCI underwent stenting of all indicated lesions with drug-eluting stents. Those assigned to FFR-guided PCI underwent FFR in each diseased coronary artery and drug-eluting stents were placed in lesions with FFR that was /=50% in 2 of 3 major epicardial coronary arteries) and an indication for PCI, that FFR-guidance may reduce stent use and improve outcomes over short-term follow-up. However, more data is needed to confirm this result and to distinguish patient populations most likely to benefit based on clinical indication for PCI and complexity of coronary anatomy.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

We celebrate the release from prison of Nigerian humanist Mubarak Bala who was convicted of the "crime" of blasphemy. FFRF Senior Litigation Counsel Sam Grover updates us on our lawsuit challenging the law requiring the posting of the Ten Commandments in Louisiana public schools. Then, we hear some shocking stories about early Christianity from Catherine Nixey, author of the book Heretic: Jesus Christ and the Other Sons of God.

Ep. 144: Pack de Potes Présente : L' Année Sobre de TKBonne Année! Pour bien démarrer cette année 2025, on vous propose un petit cadeau surprise! Comme vous le savez peut-être, notre TK a un autre podcast: Un Peu Plus Leger. Pour la troisième saison de ce podcast axé bien-être et santé, il a eu une idée : faire une année sobre, un an sans alcool! Habitué des Dry January, TK se lance avec une certaine confiance: "ce n'est finalement que un an sans alcool". Dans cet épisode, on vous présentera le début de " L' Année Sobre", que vous pouvez trouver ici. Pendant cette saison, TK va découvrir que vivre sans alcool n'est pas aussi simple que ce qu'il pensait et va se confronter à des habitudes culturelles et personnelles parfois bien ancrées. Suivez Un Peu Plus Leger et L' Année Sobre de TK sur votre plateforme de podcast préférée et sur Instagram pour ne pas rater un épisode.Et si vous-même vous sentez le besoin d'aller plus loin dans votre rapport à l'alcool, appelez Alcool Info Service au 0 980 980 930, de 8 h à 2 h, 7 jours sur 7.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

On today's FFR, Deeper Dive season cranks up another notch with a show-high 4 Deeper Dives on the show today + more notesTIMELINE || NFL Notes -- 1:30 || Deeper Dives (General) -- 28:30 || Omarion Hampton -- 30:15 || Elic Ayomanor -- 41:15 || Ricky White III -- 53:15 || CFB Playoff Rant -- 64:30 || CFB Playoff Review -- 69:00 || Brashard Smith -- 89:45 || 12/28 Bowl (BRIEF) Preview -- 101:15 || End Notes -- 104:45 This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cjfreel.substack.com

The Fed cut rates by 25bps, as expected, to 4.25-4.5% in an 11-1 split, with Hammack voting to leave rates unchanged; the median dot plot for 2025 and 2026 FFR forecasts were lifted above expectations.Fed Chair Powell said the decision was a "closer call", but the "right call", suggesting there was a discussion surrounding holding rates at this meeting, and that "extent and timing language" shows Fed is at or near the point of slowing rate cuts, and the slower pace of cuts reflects expectation. APAC stocks traded with losses across the board amid the fallout from the hawkish Fed, as sentiment from Wall Street reverberated to the region.BoJ maintained its rate at 0.25% as expected, with an 8-1 vote; Board Member Tamura dissented, advocating for a 25bps hike to 0.50%; eyes on Governor Ueda's presser.European equity futures are indicative of a softer open following the late selling stateside, with the Euro Stoxx 50 future -1.6% after cash closed +0.3% on Wednesday. Looking ahead, highlights include US Jobless Claims, Philly Fed Index, NZ Trade Balance, Japanese CPI, BoE, Riksbank, Norges, CNB, Banxico Policy Announcements, BoJ Governor Ueda, Norges Bank's Bache, Riksbank's Theeden, Supply from the UK.Read the full report covering Equities, Forex, Fixed Income, Commodites and more on Newsquawk

A.C. and Kat are back from their first semester at Shiz University for winter break, and we just had to talk about Jon M. Chu's blockbuster Broadway adaptation of Wicked: Part One. Starring Cynthia Erivo and Ariana Grande in the story before the story we all know from The Wizard of Oz, this is a tale that was originally published as a novel by Gregory Maguire in 1995. On its face it's a movie about accepting yourself when you don't fit in, but it's much more so about the way marginalized communities are threatened by authoritarian governments and the complicit neighbors who don't want to "rock the boat." We were impressed by its portrayal of class consciousness and the added nuance brought by casting a Black actress in the role of Elphaba. Finally, we hold a mini state of the union on Hollywood movie musicals.Find Kat:twitter.com/kat_ex_machinaletterboxd.com/katexmachinaFind AC:instagram.com/aclambertyletterboxd.com/aclambertyFind Us:Support Our PatreonOur WebsiteSubscribe to FFR on Apple PodcastsTwitterInstagramNEW: Letterboxd

Kat's fighting a vicious cold, and only had enough raspy voice left to record a bonus mini episode with AC this week. We caught up on all of the random movies and TV Kat watched while traveling or coughing on the couch, from Hit Man and Trap to Love Again and Hot Frosty. AC shared what movies he rewatches annually on Thanksgiving, and yes—The Silence of the Lambs is first on his list. Plus, we talk about AC's new publication with Currant Jam: Gelée, a digital zine on pop culture from emerging journalists, writers, and tastemakers.Discussed in this episode:FFR's 2021 episode about The Manchurian CandidateAC's new digital zine via Currant Jam: GeléeFind Kat:twitter.com/kat_ex_machinaletterboxd.com/katexmachinaFind AC:instagram.com/aclambertyletterboxd.com/aclambertyFind Us:Support Our PatreonOur WebsiteSubscribe to FFR on Apple PodcastsTwitterInstagramNEW: Letterboxd

The Lancet Volume 403, Issue 10438 p1753-1765May 04, 2024Background Cardiologist have long been taught that acute plaque rupture leading to myocardial infarction is more likely to come from non-flow-limiting lipid-rich atherosclerotic plaques. The concept of the vulnerable plaque is surely one of the reasons that revascularization of high-grade stable coronary artery disease does not reduce myocardial infraction or death over optimal medical therapy.The search for and treatment of the vulnerable plaque remains one of the important research areas in modern cardiology. South Korean investigators set out to test whether PCI of non-flow-limiting, high-risk vulnerable plaques identified by intracoronary imaging would reduce major adverse cardiac outcomes over medical therapy in the Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT).Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.Patients Patients were recruited in the cardiac catheterization lab. Both ACS and stable CAD patients were included. FFR was done to exclude significant flow limitations. Clinically relevant lesions with an FFR ≤ 0.80 underwent PCI with a drug-eluting stent before randomization.All untreated, non-culprit lesions (ie, those that were clearly not responsible for the presenting clinical syndrome) with an angiographic diameter stenosis of 50% or more by site visual estimation were functionally assessed by fractional flow reserve.Then, intermediate non-flow-limiting lesions (FFR >0.80) were assessed by intra-coronary imaging—with one of four techniques (at the discretion of the operator). These included grey-scale intravascular ultrasonography (IVUS), radiofrequency intravascular ultrasonography, a combination of grey-scale intravascular ultrasonography and near-infrared spectroscopy, or optical coherence tomography (OCT).Vulnerable plaques were defined as lesions possessing at least two of the following four characteristics: a minimal lumen area of less than 4·0 mm2 by IVUS or OCT; a plaque burden of more than 70% by IVUS; a lipid-rich plaque by near-infrared spectroscopy (defined as maximum lipid core burden index within any 4 mm pullback length [maxLCBI4mm] >315); or a thin-cap fibroatheroma detected by radiofrequency intravascular ultrasonography or optical coherence tomography (defined as a ≥10% confluent necrotic core with >30° abutting the lumen in three consecutive frames on radiofrequency intravascular ultrasonography or as a lipid plaque with arc >90° and fibrous cap thickness

On today's FFR, there are some brief NFL notes before a discussion about the CFB Playoff, 2025 Class Eligibility, and an introduction to Deeper Dive season.Full Write-Ups @ cjfreel.substack.comTimeline || NFL Note -- 3:20 || CFB Playoff Seeding (Maybe-Too-Early?) -- 20:50 || Updated College Eligibility & Postseason List -- 41:50 || Deeper Dives -- 55:30 || Devin Neal Deeper Dive #1 -- 60:45 This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit cjfreel.substack.com

Luke Perry biographer Margaret Wappler joined us for a conversation about her hybrid memoir profiling the '90s heartthrob, and the impact Perry had on viewers from 90210 to Riverdale. We dug into Fran Rubel Kuzui's 1992 film Buffy the Vampire Slayer, starring Perry alongside Kristy Swanson and Donald Sutherland. We particularly loved the comedic swings of supporting cast members Paul Reubens and David Arquette. Overall, we think the movie's feminist message and uneven tone are almost anachronistic, but can't deny its lasting impact.Discussed in this episode:Margaret's latest book, A Good Bad Boy: Luke Perry and How a Generation Grew UpFind Margaret:instagram.com/margaretwapplermargaretwappler.comFind Kat:twitter.com/kat_ex_machinaletterboxd.com/katexmachinaFind AC:instagram.com/aclambertyletterboxd.com/aclambertyFind Us:Join Our PatreonOur WebsiteSubscribe to FFR on Apple PodcastsTwitterInstagramNEW: Letterboxd

Writer and musician Tara Giancaspro joins Kat and A.C. for a rootin' tootin' rip-roarin' review of Colin Higgins' 1982 movie musical The Best Little Whorehouse in Texas. We get lost in the fun and charm of the music, dancing, and wigs! We delight in the beauty of Dolly Parton and Burt Reynolds! And we get caught up in a discussion of whether a movie like this could be made today, with its light-hearted treatment of sex workers being unfairly persecuted. Plus, an unhinged installment of the "what's wrong with me" game returns, as we decide which famous men we'd let watch our drinks.Discussed in this episode:Feminist Frequency Radio's 2020 episode about 9 to 5DC-based harm reduction organization HIPSFind Tara:twitter.com/sweatylamarrtaragiancaspro.substack.comsweatylamarrmusic.bandcamp.comFind Kat:twitter.com/kat_ex_machinaletterboxd.com/katexmachinaFind AC:instagram.com/aclambertyletterboxd.com/aclambertyFind Us:Support our PatreonOur WebsiteSubscribe to FFR on Apple PodcastsTwitterInstagramNEW: Letterboxd

Anita Sarkeesian returns to the podcast this week to discuss Coralie Fargeat's buzzy body horror film The Substance, starring Demi Moore and Margaret Qualley. Anita gives the movie 5 out of 5 stars, but she, Kat, and A.C. all find something uniquely different to love about it. After an electrifying in-theater experience, we couldn't stop thinking about its storytelling on the panopticon of the patriarchal gaze. Not to mention its gonzo gross-out creature work!Find Anita:twitter.com/anitasarkeesianinstagram.com/anitasarkeesianletterboxd.com/anitasFind Kat:twitter.com/kat_ex_machinaletterboxd.com/katexmachinaFind AC:instagram.com/aclambertyletterboxd.com/aclambertyFind Us:Support our PatreonOur WebsiteSubscribe to FFR on Apple PodcastsTwitterInstagramNEW: Letterboxd