POPULARITY
The lymphatic system, or lymphoid system, is one of the components of the circulatory system, and it serves a critical role in both immune function and surplus extracellular fluid drainage. Components of the lymphatic system include lymph, lymphatic vessels and plexuses, lymph nodes, lymphatic cells, and a variety of lymphoid organs. The pattern and form of lymphatic channels are more variable and complex but generally parallel those of the peripheral vascular system. The lymphatic system partly functions to convey lymphatic fluid, or lymph, through a network of lymphatic channels, filter lymphatic fluid through lymph nodes and return lymphatic fluid to the bloodstream, where it is eventually eliminated. Nearly all body organs, regions, and systems have lymphatic channels to collect the various byproducts that require elimination . Liver and intestinal lymphatics produce about 80% of the volume of lymph in the body. Notable territories of the body that do not appear to contain lymphatics include the bone marrow, epidermis, as well as other tissues where blood vessels are absent. The central nervous system was long considered to be absent of lymphatic vessels until they were recently identified in the cranial meninges. Moreover, a vessel appearing to have lymphatic features was also discovered in the eye. The lymphatic system is critical in a clinical context, particularly given that it is a major route for cancer metastasis and that the inflammation of lymphatic vessels and lymph nodes is an indicator of pathology. Structure The lymphatic system includes numerous structural components, including lymphatic capillaries, afferent lymphatic vessels, lymph nodes, efferent lymphatic vessels, and various lymphoid organs. Lymphatic capillaries are tiny, thin-walled vessels that originate blindly within the extracellular space of various tissues. Lymphatic capillaries tend to be larger in diameter than blood capillaries and are interspersed among them to enhance their ability to collect interstitial fluid efficiently. They are critical in the drainage of extracellular fluid and allow this fluid to enter the closed capillaries but not exit due to their unique morphology. Lymphatic capillaries at their blind ends are composed of a thin endothelium without a basement membrane. The endothelial cells at the closed end of the capillary overlap but shift to open the capillary end when interstitial fluid pressure is greater than intra-capillary pressure. This process permits lymphocytes, interstitial fluid, bacteria, cellular debris, plasma proteins, and other cells to enter the lymphatic capillaries. Special lymphatic capillaries called lacteals exist in the small intestine to contribute to the absorption of dietary fats. Lymphatics in the liver contribute to a specialized role in transporting hepatic proteins into the bloodstream. The lymphatic capillaries of the body form large networks of channels called lymphatic plexuses and converge to form larger lymphatic vessels. Lymphatic vessels convey lymph, or lymphatic fluid, through their channels. Afferent (toward) lymphatic vessels convey unfiltered lymphatic fluid from the body tissues to the lymph nodes, and efferent (away) lymphatic vessels convey filtered lymphatic fluid from lymph nodes to subsequent lymph nodes or into the venous system. The various efferent lymphatic vessels in the body eventually converge to form two major lymphatic channels: the right lymphatic duct and the thoracic duct. The right lymphatic duct drains most of the right upper quadrant of the body, including the right upper trunk, right upper extremity, and right head and neck. The right lymphatic trunk is a visible channel in the right cervical region just anterior to the anterior scalene muscle. Its origin and termination are variable in morphology, typically forming as the convergence of the right bronchomediastinal, jugular, and subclavian trunks, extending 1 to 2 centimeters in length before returning its contents to the systemic circulation at the junction of the right internal jugular, subclavian, and/or brachiocephalic veins. The thoracic duct, also known as the left lymphatic duct or van Hoorne's canal, is the largest of the body's lymphatic channels. It drains most of the body except for the territory of the right superior thorax, head, neck, and upper extremity served by the right lymphatic duct. The thoracic duct is a thin-walled tubular vessel measuring 2 to 6 mm in diameter. The length of the duct ranges from 36 to 45 cm. The thoracic duct is highly variable in form but typically arises in the abdomen at the superior aspect of the cisterna chyli, around the level of the twelfth thoracic vertebra (T12). The cisterna chyli, from which it extends, is an expanded lymphatic sac that forms at the convergence of the intestinal and lumbar lymphatic trunks extending along the L1-L2 vertebral levels. The cisterna chyli is present in approximately 40-60% of the population, and in its absence, the intestinal and lumbar lymphatic trunks communicate directly with the thoracic duct at the T12 level. As a result, the thoracic duct receives lymphatic fluid from the lumbar lymphatic trunks and chyle, composed of lymphatic fluid and emulsified fats, from the intestinal lymphatic trunk. Initially, the thoracic duct is located just to the right of the midline and posterior to the aorta. It exits the abdomen and enters the thorax via the aortic hiatus formed by the right and left crura of the diaphragm, side by side with the aorta. The thoracic duct then ascends in the thoracic cavity just anterior and to the right of the vertebral column between the aorta and azygos vein. At about the level of the fifth thoracic vertebra (T5), the thoracic duct typically crosses to the left of the vertebral column and posterior to the esophagus. From here, it ascends vertically and usually empties its contents into the junction of the left subclavian and left internal jugular veins in the cervical region. To ensure that lymph does not flow backward, collecting lymphatic vessels and larger lymphatic vessels have one-way valves. These valves are not present in the lymphatic capillaries. These lymphatic valves permit the continued advancement of lymph through the lymphatic vessels aided by a pressure gradient created by vascular smooth muscle, skeletal muscle contraction, and respiratory movements. However, it is important to note that lymphatic vessels also communicate with the venous system through various anastomoses. Lymph nodes are small bean-shaped tissues situated along lymphatic vessels. Lymph nodes receive lymphatic fluid from afferent lymphatic vessels and convey lymph away through efferent lymphatic vessels. Lymph nodes serve as a filter and function to monitor lymphatic fluid/blood composition, drain excess tissue fluid and leaked plasma proteins, engulf pathogens, augment an immune response, and eradicate infection. Several organs in the body are considered to be lymphoid or lymphatic organs, given their role in the production of lymphocytes. These include the bone marrow, spleen, thymus, tonsils, lymph nodes, and other tissues. Lymphoid organs can be categorized as primary or secondary lymphoid organs. Primary lymphoid organs are those that produce lymphocytes, such as the bone marrow and thymus. Bone marrow is the primary site for the production of lymphocytes. The thymus is a glandular organ located anterior to the pericardium. It serves to mature and develop T cells, or thymus cell lymphocytes, in response to an inflammatory process or pathology. As individuals age, both their bone marrow and thymus reduce and accumulate fat. Secondary lymphoid organs serve as territories in which immune cells function and include the spleen, tonsils, lymph nodes, and various mucous membranes, such as in the intestines. The spleen is a purplish, fist-sized organ in the left upper abdominal quadrant that contributes to immune function by serving as a blood filter, storing lymphocytes within its white pulp, and being a site for an adaptive immune response to antigens. The lingual tonsils, palatine tonsils, and pharyngeal tonsils, or adenoids, work to prevent pathogens from entering the body. Mucous membranes in the gastrointestinal, respiratory, and genitourinary systems also function to prevent pathogens from entering the body. Lymph Lymphatic fluid, or lymph, is similar to blood plasma and tends to be watery, transparent, and yellowish in appearance. Extracellular fluid leaks out of the blood capillary walls because of pressure exerted by the heart or osmotic pressure at the cellular level. As the interstitial fluid accumulates, it is picked up by the tiny lymphatic capillaries along with other substances to form lymph. This fluid then passes through the lymphatic vessels and lymph nodes and finally enters the venous circulation. As the lymph passes through the lymph nodes, both monocytes and lymphocytes enter it. Lymph is composed primarily of interstitial fluid with variable amounts of lymphocytes, bacteria, cellular debris, plasma proteins, and other cells. In the GI tract, lymphatic fluid is called chyle and has a milk-like appearance that is chiefly due to the presence of cholesterol, glycerol, fatty acids, and other fat products. The vessels that transport the lymphatic fluid from the GI tract are known as lacteals. Embryology The development of the lymphatic system is known from both human and animal, especially mouse studies. The lymphatic vessels form after the development of blood vessels, around six weeks post-fertilization. The endothelial cells that serve as precursors to the lymphatics arise from the embryonic cardinal veins. The process by which lymphatic vessels form is similar to that of the blood vessels and produces lymphatic-venous and intra-lymphatic anastomoses, but diverse origins exist for components of lymphatic vessel formation in different regions. Six primary lymph sacs develop and are apparent about eight weeks post-fertilization. These include, from caudal to cranial, one cisterna chyli, one retroperitoneal lymph sac, two iliac lymph sacs, and two jugular lymph sacs. The jugular lymph sacs are the first to develop, initially appearing next to the jugular part of the cardinal vein. Lymphatic vessels then form adjacent to the blood vessels and connect the various lymph sacs. The lymphatic vessels primarily arise from the lymph sacs through the process of self-proliferation and polarized sprouting. Stem/progenitor cells play a huge role in forming lymphatic tissues and vessels by contributing to sustained growth and postnatally differentiating into lymphatic endothelial cells. Lymphatic channels from the developing gut connect with the retroperitoneal lymph sac and the cisterna chyli, situated just posteriorly. The lymphatic channels of the lower extremities and inferior trunk communicate with the iliac lymph sacs. Finally, lymphatic channels in the head, neck and upper extremities drain to the jugular lymph sacs. Additionally, a right and left thoracic duct form and connect the cisterna chyli with the jugular lymph sacs and form anastomoses that eventually produce the typical adult form. The lymph sacs then produce groups of lymph nodes in the fetal period. Migrating mesenchyme enters the lymph sacs and produces lymphatic networks, connective tissue, and other layers of the lymph nodes. Function The lymphatic system's primary function is to balance the volume of interstitial fluid and convey it and excess protein molecules into the venous circulation. The lymphatic system is also important in immune surveillance, defending the body against foreign particles and microorganisms. It does so by conveying antigens and leukocytes to lymph nodes, where antigen-primed and targeted lymphocytes and other immune cells are conveyed into the lymphatic vessels and blood vessels. In addition, the system has a role in the absorption of fat-soluble vitamins and fatty substances in the gut via the gastrointestinal tract's lacteals within the villi and the transport of this material into the venous circulation. Newly recognized lymphatic vessels are visible in the meninges relating to cerebrospinal fluid (CSF) outflow from the central nervous system. Finally, lymphatics may play a role in the clearance of ocular fluid via the lymphatic-like Schlemm canals. Clinical Significance Leaks of lymphatic fluid occur when the lymphatic vessels are damaged. In the abdomen, lymphatic vessel damage may occur during surgery, especially during retroperitoneal procedures such as repairing an abdominal aortic aneurysm. These leaks tend to be mild, and the vessels in the peritoneum and mesentery eventually absorb the lymphatic fluid or chyle. However, when the thoracic duct is injured in the chest, the chyle leak can be extensive. In most cases, conservative care with a no-fat diet (medium chain triglycerides) or total parenteral nutrition is unsuccessful. In most cases, if the injury to the thoracic duct was surgical, a surgical procedure is required to tie off the duct. If the thoracic duct is injured in the cervical region, then inserting a drainage tube and adopting a low-fat diet will help seal the leak. However, thoracic duct injury in the chest cavity usually requires drainage and surgery. It is rare for the thoracic segment of the thoracic duct to seal on its own. In terms of accumulation of chyle in the thorax (i.e., chylothorax), if a patient has an injury to the thoracic duct in the thorax below the T5 vertebral level, then fluid will collect in only the right pleural cavity. If the injury is to the thoracic duct in the thorax above the T5 vertebral level, then fluid will appear in both pleural cavities. Other Issues The lymphatic system is prone to disorders like the venous and arterial circulatory systems. Developmental or functional defects of the lymphatic system cause lymphedema. When this occurs, the lymphatic system is unable to sufficiently drain lymphatic fluid resulting in its accumulation and swelling of the territory. Lymphedema, this swelling due to the accumulation of lymph, is classified as primary or secondary. Primary lymphedema is an inherited disorder where the lymphatic system development has been disrupted, causing absent or malformed lymphatic tissues. This condition often presents soon after birth, but some conditions may present later in life (e.g., at puberty or later adulthood). There are no effective treatments for primary lymphedema. Past surgical treatments were found to be mutilating and are no longer implemented. The present-day treatment revolves around compression stockings, pumps, and constrictive garments. Secondary lymphedema is an acquired disorder involving lymphatic system dysfunction that may result from many causes, including cancer, infection, trauma, or surgery. The treatment of secondary lymphedema depends on the cause. Oncological and other surgeries may result in secondary lymphedema due to the removal or biopsy of lymph nodes or lymphatic vessels. Non-surgical lymphedema may result from malignancies, obstruction within the lymphatic system, infection, or deep vein thrombosis. In most cases of obstructive secondary lymphedema, the drainage will resume if the inciting cause is removed, although some individuals may need to wear compressive stockings permanently. Also, physical therapy may help alleviate lymphedema when the extremities are involved. There is no absolute cure for lymphedema, but diagnosis and careful management can help to minimize complications. Lymphomas are cancers that arise from the cells of the lymphatic system. There are numerous types of lymphoma, but they are grouped into Hodgkin lymphoma and non-Hodgkin lymphoma. Lymphomas usually arise from the malignant transformation of specific lymphocytes in the lymphatic vessels or lymph nodes in the gastrointestinal tract, neck, axilla, or groin. Symptoms of lymphoma may include night sweats, fever, fatigue, itching, and weight loss. Cancers originating outside of the lymphatic system often spread via the lymphatic vessels and may involve regional lymph nodes serving the impacted organs or tissues. Lymphadenitis occurs when the lymph nodes become inflamed or enlarged. The cause is usually an adjacent bacterial infection but may also involve viruses or fungi. The lymph nodes usually enlarge and become tender. Lymphatic filariasis, or elephantiasis, is a very common mosquito-borne disorder caused by a parasite found in tropical and subtropical areas of the world, including Africa, Asia, the Pacific, the Caribbean, and South America. This condition involves parasitic microscopic nematodes (roundworms) that infect the lymphatic system and rapidly multiply and disrupt lymphatic function. Many infected individuals may have no outward symptoms, although the kidneys and lymphatic tissues may be damaged and dysfunctional. Symptomatic individuals may present with disfigurement caused by significant lymphedema and elephantiasis (thickening of the skin, particularly the extremities). The parasite may also cause hydrocele, an enlargement of the scrotum due to the accumulation of fluid, which may result from obstruction of the lymph nodes or vessels in the groin. Individuals presenting with symptoms have poorly draining lymphatics, often involving the extremities, resulting in huge extremities and marked disability. Lymphatic filariasis is the most common cause of disfigurement in the world, and it is the second most common cause of long-term disability. (credits: NIH)
CodeSandbox was founded in 2017 and provides cloud based development environments along with other features. It's quickly become one of the most prominent cloud development platforms. Ives van Hoorne is a Co-Founder at CodeSandbox. He joins the show to talk about the platform. Josh Goldberg is an independent full time open source developer in the The post CodeSandbox with Ives van Hoorne appeared first on Software Engineering Daily.
CodeSandbox was founded in 2017 and provides cloud based development environments along with other features. It’s quickly become one of the most prominent cloud development platforms. Ives van Hoorne is a Co-Founder at CodeSandbox. He joins the show to talk about the platform. Josh Goldberg is an independent full time open source developer in the The post CodeSandbox with Ives van Hoorne appeared first on Software Engineering Daily.
durée : 00:04:39 - Christophe Van Hoorne de la confédération paysanne - La Confédération paysanne a réuni une cinquantaine d'éleveurs, hier, à Xertigny dans les Vosges devant des locaux de Lactalis qui collecte le lait près d'Epinal. L'objectif était de dénoncer le choix du géant laitier de moins collecter dans les exploitations françaises dès l'an prochain.
FC Knudde-tekenaar Toon van Driel gaat in zee met een investeerder die een kruising tussen een attractiepark en een vakantiepark wil gaan maken rondom de succesvolle strip: Knuddeland. Van Driel heeft FC Knudde 'min of meer' verkocht aan ondernemer Michael van Hoorne, vertelt hij in deze podcast.
In deze aflevering 'Van blunders tot succesgeheimen' ga ik in gesprek met Michael van Hoorne, CEO Van Hoorne Entertainment. Michael neemt je mee in zijn reis van acteur naar directeur en laat je zien dat je ook door veel dingen doen en veel fouten maken je dromen waar kunt maken. Elke dag mag hij, samen met zijn collega's en characters, gasten gelukkig maken. Zowel in een van de parken, het theater als bij de gasten thuis. Uiteraard kom je alles te weten over zijn blunders en succesgeheimen.
Welkom bij de vierde aflevering van de PrentenboekenCast, waarin we vertellen over versjes- en prentenboeken voor kinderen van 0 tot 6 jaar. Het THEMA van deze aflevering is boeken uit 2022. Binnen dit thema bespreken we een baby-,dreumes-, peuter-, kleuter én versjesboek. Tot slot vertelt Mark over zijn favoriete boek dat zijn ouders aan hem voorgelezen hebben en hij weer aan zijn kinderen. Een echte klassieker, uit 1969, die nog steeds heel goed te gebruiken is in deze tijd! Boeken die we in deze aflevering bespreken:Baby- Dreumesboek: BOE BOE DAAR IS KOE van Camilla Reid met illustraties van Claire Youngs, Uitgeverij Gottmer maart 2022 Dreumes- Peuterboek: MIKE EN MOLLY, TEL JE MEE? Auteur van Hoorne met illustraties van Anet van de Vorst, Uitgeverij Witte Leeuw juli 2022 Peuterboek: FRANK EN BERT van Chris Naylor-Ballesteros/ Uitgeverij Gottmer augustus 2022 Kleuterboek: NIET SLECHT! van Julia Donaldson met illustraties van Axel Scheffler, Uitgeverij Gottmer juli 2022GERED! van Bette Westera met illustraties van Matthias de Leeuw, Uitgeverij Lannoo augustus 2022Versjesboek: RIJEN, RIJEN, RIJEN IN EEN WAGENTJE van Marije ten Cate, Uitgeverij Lemniscaat april 2022 Het favoriete boek van: Mark RUPSJE NOOITGENOEG van Eric Carle, Uitgeverij Gottmer 1969 Volg ons ook via: https://www.instagram.com/prentenboekencast/
Ik was voor deze aflevering te gast in de Alblasserwaard, bij Van Hoorne Entertainment waar ik sprak met eigenaar en oprichter Michael van Hoorne. Van Hoorne Entertainment is in Nederland de grootste speler in het familieamusement. Doornroosje, Assepoester, Roodkapje en, Rapunzel: de familiemusicals vormen een constante in het Nederlandse theateraanbod. Bovendien bezit Van Hoorne de licenties van Peppa Pig, Thomas de Stoomlocomotief, Brandweerman Sam en een deel van Woezel en Pip. Maar het grootste avontuur - en direct aanleiding om eens langs te komen vormden de Avonturenboerderij Molenwaard, een themapark met educatieve waarde, dat is gebouwd rondom de boerenkinderen Fien en Teun. Met zo'n 300.000 bezoekers een zeer populaire en bekroonde dagattractie. Sinds vorig jaar is daar ook nog eens vakantiepark Molenwaard bij gekomen, een vakantiepark volledig gethematiseerd in de stijl van Fien en Teun. Samen beleef je een kleine versie van Disneyworld in de polder. We gaan in gesprek met Michael over 'hekel hebben aan middelmatigheid', internationale ambities in de polder en het 'Van Hoorne familie' gevoel. Geniet van deze aflevering van de podcast! https://www.vakantieparkmolenwaard.nl/ https://www.avonturenboerderij.nl/ https://www.vanhoorne.com/ https://www.linkedin.com/in/michael-van-hoorne-a4756621/ Feedback, suggesties en advies zijn welkom en mogen via richard@redonlinemarketing.nl Deze podcast is mede mogelijk gemaakt door: Luc Nieuwenhuijzen (montage en geluid), Pretwerk.nl (promotie) en RED online marketing (studio en apparatuur). Zoek jij nog een leuke baan? Momenteel zoekt RED online marketing zowel in Utrecht, Bordeaux als München slimme online marketeers, stagiairs en trainees. Ben jij de versterking voor het team? Doe een open sollicitatie. https://redonlinemarketing.nl/vacatures/ MOJO by tubebackr https://soundcloud.com/tubebackr Creative Commons — Attribution-NoDerivs 3.0 Unported — CC BY-ND 3.0 Free Download / Stream: http://bit.ly/-moj Music promoted by Audio Library https://youtu.be/OtmdW44-5
SOURCES, une structure qui a pour vocation de soutenir toutes les femmes et de les faire se réunir pour retrouver la force du collectif. Chloé Van Rossom et Valérie Hoorne les co-fondatrices seront nos invitées.
SOURCES, une structure qui a pour vocation de soutenir toutes les femmes et de les faire se réunir pour retrouver la force du collectif. Chloé Van Rossom et Valérie Hoorne les co-fondatrices seront nos invitées.
In deze uitgebreide podcast praat Mario met Michael van Hoorne van Van Hoorne Entertainment. Michael is één van de vele vrije theaterproducenten die Nederland rijk is. Deze producenten vinden het - om meerdere redenen - van belang dat de theaters weer spoedig open gaan. Michael legt uit waarom. Wat is het plan dat de VVTP heeft en hoe denkt deze vereniging van vrije theaterproducenten onder welke voorwaarden dat zou kunnen?
On today's episode, we're going to talk about fostering developer collaboration in a remote world. This is a special edition because Sarah Dayan is joined for the first time by her new co-host Bryan Robinson, Senior Developer Advocate at Algolia. Working remotely is not something new, especially in the tech industry, but since the beginning of the pandemic in 2019, there has been a wave of tech workers going remote. First it was by necessity, and then by choice. So how do you collaborate when your coworkers are not in the same room, not in the same city, country or even continent? How did it change our processes and our tools?Our guest today is Ives Van Hoorne, creator of CodeSandbox. CodeSandbox is the most advanced cloud-based sandbox environment that lets developers quickly start and share prototypes, but also collaborate on projects, provide bug reproductions, and all of that in the browser.Ives Van Hoorne: @compuivesBryan Robinson: @brobSarah Dayan: @frontstuff_ioCodeSandbox: @codesandbox / codesandbox.ioAlgolia: @algolia / algolia.com
Isabelle Rich Van Hoorne, associée chez ConvictionsRH, était l'invitée de Christophe Jakubyszyn dans Good Morning Business, ce mercredi 27 octobre. Ils sont revenus surétude annuelle sur la féminisation des instances dirigeantes des entreprises en France sur BFM Business. Retrouvez l'émission du lundi au vendredi et réécoutez la en podcast.
« Ce que j'observe, c'est cette lame de fond d'hommes qui osent beaucoup plus, qui osent sortir de la norme sociale, du cadre qui est celui qu'on connaît en France depuis des siècles et qui osent dire « je peux peut-être faire différemment, j'ai envie de m'écouter ». On parle beaucoup de la pudeur des hommes, je n'en suis pas si convaincu que ça. Quand tu ouvres un espace, tu te rends compte qu'ils sont prêts à parler, qu'ils ont envie de partager. » « Je sais pas qui décide si ça se fait ou ça se fait pas, en tout cas, nous, on le fait. » Salut mes chers Equilibristes Je suis très heureuse de vous retrouver aujourd'hui et impatiente de vous partager ma discussion avec Pascal. Vous m'aviez demandé d'entendre plus de pères, et j'étais bien d'accord avec vous sur le fait qu'il est important de leur laisser plus de place sur les sujets que nous traitons dans les Equilibristes. Vous savez comme je demande souvent à mes invités et invitées s'ils avaient anticipé l'impact de l'arrivée de leurs enfants sur leur carrière. Pascal Van Hoorne, mon invité de cette semaine, est un des premiers pères à m'avoir répondu « oui ». Pascal se décrit lui-même comme slasher, c'est-à-dire qu'il cumule plusieurs activités professionnelles. Il est aussi le père de deux jumeaux de 4 ans ½. Pascal a fait des choix engageants avant la naissance de ses jumeaux, dans l'idée d'aligner son mode de vie aux valeurs qu'ils souhaitaient leur transmettre. Avec Pascal, nous avons beaucoup parlé des étapes de vie, de carrière, de la manière dont chaque étape constitue une brique pour construire la suite. Nous avons parlé d'entrepreneuriat et d'intrapreneuriat, de la valeur de l'exemplarité et de la nécessité de normaliser les discussions autour de la parentalité en entreprise. Nous avons aussi beaucoup parlé des pères, qu'il observe de près et met en lumière à travers son blog Histoires de papas, dans la même ambition que celle qui m'anime dans Les Équilibristes : montrer un maximum de réalités, de choix, de vies, pour inspirer les autres, inventer de nouvelles possibilités. Oser faire différemment. Se créer de la liberté dans le cadre (quitte à le bousculer un peu quand même). C'est une bonne question ça ! A très vite et take good care. En avant les Équilibristes ! Sandra ********************************************* Si vous aimez Les Equilibristes, prenez quelques instants pour le dire sur votre plateforme d'écoute préférée, en laissant 5 ⭐ et un commentaire. Mille mercis pour votre soutien !
In this episode of By Any Means Necessary, hosts Sean and Jacquie are joined by Assata, Communications Director for the Central Gulf Coast People's Council, to talk about the mutual aid efforts being made in the region in the aftermath of Hurricane Sally, the lack of state assistance for working people already struggling amid the pandemic, and how to help.In the second segment, Sean and Jacquie are joined by technologist Chris Garaffa to discuss the details of the trillion-dollar "fraud" reported by the International Consortium of Investigative Journalists, the seemingly-extortionary tactics employed by the US government in its attempt to acquire TikTok, and Apple's role in providing information to the government on protesters accused of criminal behavior.In the third segment, Sean and Jacquie are joined by Dr. Seyed Mohammad Marandi, Professor of English Literature and Orientalism at the University of Tehran, to talk about the floundering US attempts to impose 'snapback' sanctions on Iran under the terms of the nuclear agreement it abandoned, why the Trump administration has "no one to blame but" itself for the lack of cooperation, and how the recent rejection of a coronavirus resolution condemning multilateral sanctions (which the UN approved almost unanimously) demonstrates the US government is increasingly out of step with the rest of the world.Later in the show, Sean and Jacquie are joined by Dr. Gerald Horne, Moores Professor of History and African American Studies at the University of Houston, to talk about the impacts of the recent death of Supreme Court Justice Ruth Bader Ginsburg, how the historical "Faustian bargains" between the ruling class and many supposedly-progressive Democrats paved the way for a descent into "neo-fascism," and his upcoming book, “The Bittersweet Science: Racism, Racketeering and the Political Economy of Boxing.”
On parle de ce qu'il peut arriver dans la vie des devs dans cet épisode
Inspiratie is voor een dichter niet steeds de meest betrouwbare partner, en dan is terugvallen op vakmanschap je redding. Poëzie is een ambacht. Het advies van Philip Hoorne is dan ook: schrijf veel. BIJHORENDE VIDEO’S Luister ook naar akim a.j. willems https://youtu.be/hvZYzzQunjc Verslag boEgie woEgie 2018 https://youtu.be/rp32MbiNxak Poëzie in ‘t Gesproken Dagblad https://youtu.be/kbSDMW-YHKI Dichters in ‘t Gesproken Dagblad https://youtu.be/HMFRSKaxIh4 Boekvoorstelling 'Ondoorgrond' https://youtu.be/-gpRZ3r_xqE Afspeellijst Kunst, ambachten en technieken https://www.youtube.com/playlist?list=PLkbFihObH-1LUO-Jw2Y1fKirmLvT9OwP0 REFERENTIES OPNAME Philip Hoorne op het boEgie woEgie kunstenfestival, 23 november 2019, in CC De Steiger, Menen, West-Vlaanderen. Het boEgie woEgie kunstenfestival mengt poëzie, muziek, dans, beeldende kunst, literatuur en architectuur op één dag. Hoofdredacteur Jozef Deleu introduceerde het nieuwste nummer van het tijdschrift ‘Het Liegend Konijn’ en daarna de dichters Mattijs Deraedt, Dominique De Groen, Philip Hoorne en akim a.j. willems. Site dichter: https://philiphoorneskynet.wordpress.com Site festival: http://www.bgwgkunstenfestival.be Site tijdschrift: http://www.hetliegendkonijn.be Het Liegend Konijn wordt uitgegeven door Uitgeverij Polis. Er verschijnen twee nummers per jaar, telkens in april en in oktober, met uitsluitend nieuwe, niet eerder gepubliceerde gedichten. VOLG IKWASHIER.LIVE • Facebook https://www.facebook.com/ikwashier.live • YouTube https://www.youtube.com/ikwashierlive • Instagram https://www.instagram.com/ikwashier.live • Twitter https://twitter.com/LodewijkDeleu PODCAST ‘BEGINNEN MET ERFGOED’ • http://beginnenmeterfgoed.vlaanderen • https://www.youtube.com/playlist?list=PLkbFihObH-1JuxGwSGoYLvryZa3vnX_fH WELKOM • Filmarchief https://www.youtube.com/ikwashierlive • Fotoarchief http://www.ikwashier.live • Radioarchief https://www.youtube.com/playlist?list=PLkbFihObH-1IPedtBHSCnX-xkThk21_FY COPYRIGHT © Foto, interview: Lodewijk Deleu - http://www.ikwashier.live © Muziek: Chanson for Siv by Ian Post, License owner - Lodewijk Deleu, Company - Magazinemaker.be INFO NL Als documentair fotograaf, filmmaker en journalist documenteert, archiveert en ontsluit Lodewijk Deleu tradities, erfgoed en kunst. Dit met bijzondere aandacht voor immaterieel erfgoed en vooral die gewoontes en gebruiken die dreigen te verdwijnen. INFO FR ikwashier.live du photographe, cinéaste et journaliste Lodewijk Deleu inventorie les traditions, le patrimoine culturel immatériel et l’art. Le nom “ik was hier” signifie “j’étais ici”. INFO E Documentary photographer, filmmaker and journalist Lodewijk Deleu aims with ikwashier.live an inventory of traditions, intangible cultural heritage and art. The name “ik was hier” means “I was here”.
Afgelopen week maakte CodeSandbox bekend $2,4 miljoen te hebben opgehaald bij Kleiner Perkins, het Nederlandse Arches Capital en nog wat angel investors. Ik sprak Ives van Hoorne en Bas Buursma ongeveer twee maanden hiervoor bij mij op kantoor in Utrecht over o.a. hun ervaringen met fundraising aan beide kanten van de oceaan, het besluiten om te stoppen met de studie om vol overgave te gaan ondernemen en hun tweetrapsraket om van CodeSandbox een miljardenbedrijf te maken.
Upcoming events: A Conversation with Haseeb Qureshi at Cloudflare on April 3, 2019 FindCollabs Hackathon at App Academy on April 6, 2019 Coding in the browser has been attempted several times in the last decade. Building a development environment in the browser has numerous technical challenges. How does the code execute safely? How do you The post CodeSandbox: Online Code Editor with Bas Buursma and Ives van Hoorne appeared first on Software Engineering Daily.
Recording date: 2018-11-29 John Papa https://twitter.com/john_papa Ward Bell https://twitter.com/wardbell Dan Wahlin https://twitter.com/danwahlin Ives van Hoorne https://twitter.com/compuives Resources: CodeSandbox https://codesandbox.io Elixr https://elixir-lang.org/ Erlang https://www.erlang.org/ Reactjs https://reactjs.org/ NPM https://www.npmjs.com/ Serverless https://martinfowler.com/articles/serverless.html Unpkg https://unpkg.com/ Pupeteer https://github.com/GoogleChrome/puppeteer Kubernetes https://kubernetes.io/ Redux https://redux.js.org/ Cerebral https://github.com/cerebral/cerebral CodePen https://codepen.io Monaco https://github.com/Microsoft/monaco-editor Code https://code.visualstudio.com/ Typescript https://www.typescriptlang.org/ Flow https://flow.org/en/docs/frameworks/react/ Someone to follow: Netanel Basal https://netbasal.com Ana Cidre https://twitter.com/AnaCidre_ Kyle Matthews https://twitter.com/@kylemathews / Gatsbyjs https://twitter.com/gatsbyjs Timejumps 1:00 Mailbag question: Will VSCode editor replace the current editor? 3:01 What is Codesandbox and how did you get into it? 6:30 What kinds of challenges did you face when launching Codesandbox? 10:00 What are you using for serverless functions? 13:10 Why use serverless? 16:10 Sponsor: Nativescript 17:15 Moving away from serverless for some things? 23:10 What do you think of suspense or hooks? 24:20 Why does the world need Codesandbox? 28:00 What does Codesandbox use for linting? 31:00 Sponsor: IdeaBlade https://www.ideablade.com 32:30 What is Codesandbox written in? 35:20 How are the users of Codesandbox using types? 36:20 How do you keep up with the latest versions of software? 41:00 How do you handle concurrent users? 42:10 Someone to follow
In this episode, Nick talks with Ives van Hoorne about his project CodeSandbox. They chat about Ives deciding to work on it full-time, how CodeSandbox is built, some of its best features, and what lies ahead.
In this episode, Nick talks with Ives van Hoorne about his project CodeSandbox. They chat about Ives deciding to work on it full-time, how CodeSandbox is built, some of its best features, and what lies ahead.
We are joined by Ives Hoorne, a developer at Catawiki and creator of code sandbox. Today he talks about how he began writing code, how Minecraft modding made him love it, his interest in the company Catawiki and how he taught himself web development to work there, and finally the future for his projects.Ives began coding at 11 years old. He was fascinated by secret languages, so he and his friend made a program in Visual Basic that would jumble text and another that would decipher the text. They would send these to each other as public facebook messages. It fell off after this project for awhile. After a few years, Ives got back into it when Minecraft came around, and he started writing mods for it.The success and popularity of Code Sandbox made Ives happy. He enjoys how it became popular and how some of the bigger names such as Dan Abramov started talking about it. Though Ives discussions about how this positive feedback caused him to attach his self-worth to the project, and how he had to let that go so he wouldn't be hurt by snarky feedback and other forms of negativity related to his project.There were a couple of surprises in the development of Code Sandbox. Code Sandbox stores all files and directories in their Postgres database. When they fork Code Sandbox, they copy all the files, directories, and sandboxes over. Ives thought this wouldn't scale but somehow they now have 400k sandboxes, and the database is only four gigabytes! One of the negative surprises was when there was an error in the sandbox when someone tries to share their sandbox, the preview service would try over and over again to take a snapshot. The following month their hosting bill was a dozen times the price as it usually was!Ives' first experience speaking at a conference was much better than he expected. When he was presenting, he noticed that he was talking with a bunch of people who were willing to listen to him. It was such a cool experience for him that he now loves speaking at conferences for him. Ives says he wants to start talking about things besides Code Sandbox, such as UI driven development for example. He says that it can be greatly improved, npm installing is still manually typing npm install package-name. He says that this can be made much better by being able to search for dependencies and directly add them with a single click.Finally, Ives talks about his plans for Code Sandbox. He plans on adding a dashboard because currently, it's very cumbersome to navigate to your sandbox. The dashboard will give you the ability to put sandboxes in directories organizing them that way. They are also managing offline support. Finally, they are adding team support so multiple people can all work on a sandbox at once.Transcript"Ives Van Hoorne, creator of CodeSandbox" TranscriptResources:Code SandboxcatawikiIves Van Hoorne:GithubWebsiteTwitterJohn Lindquist:TwitterWebsite
Ives van Hoorne is the creator of Codesandbox; an online code editor written completely in React. Although Codesandbox is written in React, it can be used to build applications for any front-end framework.
Ives van Hoorne is the creator of Codesandbox; an online code editor written completely in React. Although Codesandbox is written in React, it can be used to build applications for any front-end framework.