Podcasts about Utrecht

City and municipality in the province of Utrecht, Netherlands

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De Jortcast
#557 - Wordt Jort vervangen door een computer?

De Jortcast

Play Episode Listen Later Feb 2, 2023 28:04


Kom je uit het zuiden of oosten van het land? Dikke kans dat de spraakherkenning van je navigatie of Google Assistant jou niet verstaat. De komst van AI als ChatGTP en spraakbesturing zullen kleine talen en dialecten wegvagen, vreest prof. dr. Antal van den Bosch, hoogleraar Taal, Communicatie en Computatie ie aan de Universiteit van Utrecht. Dat en meer over de robot die al je werkstukken en binnenkort misschien ook Jorts teksten schrijft, in deze aflevering van de Jortcast.

History of the Germans
Episode 93 -Frederick II's Afterlife

History of the Germans

Play Episode Listen Later Feb 2, 2023 34:38 Transcription Available


On July 7th, 1285, a sunny day in the city of Wetzlar, a day's ride north of Frankfurt acrid smoke rises from a mighty pyre built up just outside its walls. The pyre was for an emperor, or at least a man who claimed to be the emperor Fredrick II. This man had shown up in the Rhineland, gathered followers, set up a court and sent letters to prince and cities across the realm. Envoys had come from Italy to find out whether the Stupor Mundi had indeed returned. King Rudolf of Habsburg had to turn up in person at the head of an army to sort things out. Just before the fires were lit the (fake) emperor called on to his followers to proceed to Frankfurt as planned where he would re-appear in three days' time.He did not reappear in Frankfurt but in Utrecht, where the imposter was hanged. The next sighting was in Lübeck in 1286, where he was killed again. In 1295 he was again captured and burned at the stake. The myth of the emperor who lives and does not live persisted over the centuries. Sometime in the 15th or 16the century the myth transfers from Frederick II to Barbarossa who now dwelt in the Khyffhaueser mountain waiting to be called. Frederick II was relegated to a secondary role amongst the great medieval emperors until in 1927 a hitherto unknown writer, Ernst Kantorowics published his biography of Frederick II. This book became the most intensely discussed and most controversial biographies of a medieval ruler – full stop. Its view of the emperor was suffused with the right-wing ideology of the George Kreis. Hitler allegedly read it twice, it was on Goebbels' bedside table, but at the same time Claus von Stauffenberg, the leader of the July plot to assassinate Hitler was a friend of Kantorowics and Admiral Canaris, another key conspirator asked for the book to read before his execution. Its Jewish author disliked the Nazis despite his extreme right-wing views. He fled Germany in 1938 and distanced himself from his most famous work. In the US he got caught in the nets of McCarthyism when he refused to swear an oath to fight communists. A rare case where the biographers biography is almost as fascinating as his subject, well worth exploring. The music for the show is Flute Sonata in E-flat major, H.545 by Carl Phillip Emmanuel Bach (or some claim it as BWV 1031 Johann Sebastian Bach) performed and arranged by Michel Rondeau under Common Creative Licence 3.0.As always:Homepage with maps, photos, transcripts and blog: www.historyofthegermans.comFacebook: @HOTGPod Twitter: @germanshistoryInstagram: history_of_the_germansReddit: u/historyofthegermansPatreon: https://www.patreon.com/Historyofthegermans3a5cc4e46cef307bf2afc25b3675c63504ed8061

Less Stressed Life : Upleveling Life, Health & Happiness
#280 Is the answer to health problems as simple as structured coherent water? with Analemma Water

Less Stressed Life : Upleveling Life, Health & Happiness

Play Episode Listen Later Feb 1, 2023 68:09 Transcription Available


We know about vapor, liquid and ice but what if I told you water has another state? Today we're talking about the preferred state of water between liquid and ice, which is structured or coherent water. In nature, the natural vortex of water movement creates structured water.When you use a structured or coherent water wand, the water gains immediately clarify and the taste becomes smoother. This is something I had to see and taste to believe, but the results are obvious.In this episode, I sit down with Analemma Water founder Dr. Eric Laarakker, a holistic veterinarian that was looking for ways to optimize health and resident structured water afficionado Mario Brainovic.We cover:How structured water helps plants grow up to 50% more efficiently in their studies.Calming or positive changes in brain waves seen in as little as 20 seconds after consumption of structured water.EMFs and the microbiota and it's relationship to the cosmos/energyOpportunities to improve ag/animal production with structured waterI've had the opportunity to use the Analemma wand (we call it the magic wand at our house) and another device that is supposed to structure water and the Analemma wand created a notable different in smooth taste and water clarity whereas the other water structuring option I tried created no discernible change.WHERE TO FINDYou can try an Analemma wand yourself & get a discount with code: lessstressed at https://analemma-water.com/WHERE TO FIND CHRISTA:https://www.christabiegler.com/On IG: instagram.com/anti.inflammatory.nutritionist/Leave a review, submit a questions for the podcast or take one of my quizzes here:  https://www.christabiegler.com/linksABOUT THE GUESTS: Dr. Eric Laarakker, DVM has been working as a holistic veterinarian and researcher, ever since he graduated as veterinarian from the Dutch University of Utrecht, Faculty of Veterinary Medicine in 1992. Being interested in ways to optimize health, his research led him to the exploration of water, its properties, and how the quality of water can further be elevated. For the last 14 years, Dr. Laarakker has examined the properties of water, conducting numerous experiments and studies to see how the structure of the water affects its quality, and how optimal structure of water can be achieved and maintained.Mario Brainović is an entrepreneur, researcher and a visionary in the field of health and wellness. For years he ran a successful international advertising agency and a production house. He was always very passionate about health and wellness, about finding natural ways to heal, regenerate and restore the delicate balance between body, mind and spirit. This led him to establish a natural pharmaceutical company that successfully helped many people for years. After a while he became very passionate about water. Realizing its extraordinary significance he established New Earth Technologies, a company that offers the miracle of Analemma Water to the world.

De Derde Helft - Eredivisie
Speelronde 19 met SANDER SCHIMMELPENNINCK: ‘Als Twente kampioen wil worden, moeten ze Jans ontslaan'

De Derde Helft - Eredivisie

Play Episode Listen Later Jan 29, 2023 47:39


Welkom bij De Derde Helft. Zoals altijd behandelen wij alle potjes en alle teams na elke speelronde. Deze aflevering schoof Sander Schimmelpenninck aan om het samen met Snijboon, Tim en Gijs onder meer te hebben over Van der Sar die alle camera's moet ontwijken, een turbo-topper in Twente, Utrecht en AZ dansen de sirtaki, PSV bedwingt de eerste crisis, Oranjekoorts in Volendam en Kurt van de Paar.Kortom: alle antwoorden op vragen die je niet per se had.

CURSO DE FILOSOFÍA
Curso de Filosofía: Positivistas alemanes del XIX. Büchner, Moleschott, Dühring-

CURSO DE FILOSOFÍA

Play Episode Listen Later Jan 22, 2023 31:52


Un saludo amigos y mecenas. Hoy os ofrezco una exposición del positivismo alemán del XIX, una filosofía que no gustó nada a los comunistas (tanto Marx como Engels escribieron contra ellos) y que inició agrias polémicas con los científicos cristianos. Su tesis principal es que la ciencia es el único conocimiento posible y todo puede explicarse mediante presupuestos materialistas. ÍNDICE: 1. Jakob Moleschott y la sacralización de la materia y de la vida. Nacido en Bolduque (Países Bajos) en 1822, Moleschott estudió en la Universidad de Heidelberg, empezando sus prácticas de medicina en Utrecht en 1845, desplazándose más tarde de nuevo a Heidelberg, donde se graduó en fisiología en 1847. Posteriormente ejercería como profesor de fisiología en Zürich (1856), Turín (1861), y Roma (1879), donde falleció en 1893. 2. Carl Vogt (positivista materialista), opuesto a Rudolf Wagner (científico cristiano alemán) con respecto a la existencia del alma. Vogt (5 de julio 1817 - 5 de mayo 1895), fue un destacado científico alemán que emigró a Suiza. Realizó varias aportaciones dentro de la zoología, la geología y la fisiología. También incursionó en la política, ya que fue miembro del Parlamento de Fráncfort, en Alemania, y más tarde se involucró en la política de Suiza. 3. Ludwig Büchner y la eternidad de la materia. Büchner (Darmstadt, 29 de marzo de 1824 - 1 de mayo de 1899) fue un filósofo, escritor y médico alemán del siglo XIX. Fue partidario de las ideas de Charles Darwin y defendió la primacía exclusiva de la ciencia y la materia como fuente de conocimiento por encima de todas las formas de saber teológico y metafísico. 4. Emil Du Bois-Reymond y «los siete enigmas del mundo». Emil du Bois-Reymond (7 de noviembre de 1818 - 26 de diciembre de 1896) fue un médico y fisiólogo alemán descubridor del potencial de acción nervioso y desarrollador de la electrofisiología experimental. 5. Ernst Haeckel y el mundo sin enigmas. Haeckel (Potsdam, 16 de febrero de 1834-Jena, 9 de agosto de 1919),​ fue un naturalista y filósofo alemán que popularizó el trabajo de Charles Darwin en Alemania, creando nuevos términos y conceptos como «ecología», «filo», «ontogenia», «filogenia», «monofilético» o «polifilético». 6. El positivismo social de Ernst Loas y Friedrich Jodl. 7. Eugen Dühring y el socialismo personalista. Dühring (12 de enero de 1833, Berlín - † 21 de septiembre de 1921, Berlín) fue un profesor de mecánica, abogado, filósofo y economista alemán. Friedrich Engels escribe entre 1877 y 1878, "La subversión de la ciencia por el señor Eugen Dühring", más conocido como Anti-Dühring, en el quepolemiza con dicho autor, abordando la filosofía, la sociología y las ciencias naturales desde un punto de vista marxista. ***** Música de la época: Sinfonía nº 6 de Chaikovski "Patética", estrenada en octubre de 1893, unos meses después del fallecimiento de Jacob Moleschott. **** Imagen de Eugen Dühring. ****** Pulsen un Me Gusta y colaboren a partir de 2,99 €/mes si se lo pueden permitir para asegurar la permanencia del programa ¡Muchas gracias a todos!

Immersive Audio Podcast
Immrsive Audio Podcast Episode 73 Arjen Van Der Schoot (Audio Ease)

Immersive Audio Podcast

Play Episode Listen Later Jan 20, 2023 84:46


This episode is sponsored by Spatial, the immersive audio software that gives a new dimension to sound. Spatial gives creators the tools to create interactive soundscapes using our powerful 3D authoring tool, Spatial Studio. Their software modernises traditional channel-based audio; by rethinking how we hear and feel immersive experiences, anywhere. To find more go to https://www.spatialinc.com. In this episode of the Immersive Audio Podcast, Oliver Kadel and Monica Bolles are joined by the co-founder at Audio Ease - Arjen Van Der Schoot from Utrecht, Netherlands. Arjen studied music technology at the Utrecht School of Arts. After which Arjen and 4 of his fellow graduates started Audio Ease in 1995. He was freelancing recording Classical music, Minoring in Classical guitar and majoring in software development for audio and music. Together they made about 10 products before their big break with Altiverb which became an industry standard. The 360pan suite came out of the fierce hope that an old affection - ambisonics, would now finally definitely make it, because somebody thought of it in the context of head-tracked VR, an application that requires headphones, in Arjen's opinion the only medium it is perfect for. Arjen tells a fascinating story of the creation of Audio Ease and the famous Altiverb and we explore the topic of convolution for spatial audio. This episode was produced by Oliver Kadel and Emma Rees and included music by Rhythm Scott. For extended show notes and more information on this episode go to https://immersiveaudiopodcast.com/episode-73-arjen-van-der-schoot-audio-ease/ If you enjoy the podcast and would like to show your support please consider becoming a Patreon. Not only are you supporting us, but you will also get special access to bonus content and much more. Find out more on our official Patreon page - www.patreon.com/immersiveaudiopodcast We thank you kindly in advance! We want to hear from you! We value our community and would appreciate it if you would take our very quick survey and help us make the Immersive Audio Podcast even better: surveymonkey.co.uk/r/3Y9B2MJ Thank you! You can follow the podcast on Twitter @IAudioPodcast for regular updates and content or get in touch via podcast@1618digital.com immersiveaudiopodcast.com

Stroke Alert
Stroke Alert January 2023

Stroke Alert

Play Episode Listen Later Jan 19, 2023 44:57


On Episode 24 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2023 issue of Stroke: “Covert Brain Infarction as a Risk Factor for Stroke Recurrence in Patients With Atrial Fibrillation” and “Subarachnoid Hemorrhage During Pregnancy and Puerperium.” She also interviews Dr. Georgios Tsivgoulis about his article “Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.” Dr. Negar Asdaghi:         Let's start with some questions. 1) When during pregnancy is an intracranial aneurysm at the highest risk of rupture? 2) What does the presence of covert brain infarcts mean in the setting of atrial fibrillation? 3) And, finally, how is the inflammatory form of cerebral amyloid angiopathy different from the classic CAA form, and why is it important to differentiate between the two? We'll be answering these questions and much more in today's podcast. We're covering the latest in cerebrovascular disorders, and this is the best in Stroke. Stay with us. Welcome back to another issue of the Stroke Alert Podcast. My name is Negar Asdaghi. I'm an Associate Professor of Neurology at the University of Miami Miller School of Medicine and your host for the monthly Stroke Alert Podcast. Together with my co-editors, Drs. Nastajjia Krementz and Eric Goldstein, here's our article selection for the month of January. Symptomatic intracerebral hemorrhage is a feared complication of reperfusion therapies in acute stroke, so there's a lot of interest in looking for predictors of development of this complication, especially when you're making decisions for pursuing endovascular therapy. For many years now, we've known about some of these predictors, such as presence of a large infarct core and high blood glucose levels. But in the recent years, other radiographic markers of tissue viability, such as a poor collateral status and unfavorable venous outflow profile, have been shown to be predictors of post-reperfusion hemorrhagic transformation. In this issue of the journal, we learn about another imaging marker that can potentially predict parenchymal hemorrhage occurrence post-endovascular therapy, which is high hypoperfusion intensity ratio, or HIR, as measured by perfusion imaging. What is HIR? It's a long name for a simple ratio that can easily be measured by dividing the volume of tissue with Tmax delay of over 10 seconds to the volume of tissue with Tmax delays of over 6 seconds. Simply put, Tmax 10 divided by Tmax 6. These volumes, as you know, are typically provided to us by almost all post-processing perfusion softwares, and so this ratio can be easily calculated in the acute setting. So, in this paper led by Dr. Tobias Faizy from University Medical Center in Hamburg and colleagues, we learned that higher hypoperfusion intensity ratios are strongly associated with parenchymal hemorrhage occurrence after endovascular therapy. So, in summary, HIR, that is a quantitative ratio, can be used as a marker to risk stratify patients that are undergoing endovascular therapy in terms of helping us predicting the risk of development of intracerebral hemorrhage after reperfusion therapies. In a separate study in this issue of the journal, we read a very interesting paper titled "Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk." How are intracranial aneurysms even related to anti-epileptic drugs? Well, first of all, it's been known for a long time based on genome-wide association studies that there are multiple common genes that are associated with increased risk of intracranial aneurysm development. Now, some of the largest genetic studies to date have shown pleiotropy between genetic causes of development of intracranial aneurysms and genes encoding targets for anti-epileptic drugs. Now that's a fascinating finding because finding commonalities between these genes may help find new treatment targets for intracranial aneurysms. So, in this paper in this issue of the journal, the investigators from the University Medical Center in Utrecht found an association in the expression of anti-epileptic drug target gene CNNM2 and intracranial aneurysm risk. They found that certain anti-epileptic drugs, such as phenytoin, valproic acid, and carbamazepine, that are expected to lower CNNM2 levels in the blood may subsequently lead to a lower risk of development of intracranial aneurysms. And, of course, a reasonable follow-up study to this would be to investigate whether persons exposed to these anti-epileptic drugs have indeed a lower risk of unruptured intracranial aneurysms and subarachnoid hemorrhage, and how variation in CNNM2 expression can lead to development of aneurysms. Bottom line, CNNM2 may be a relevant drug target for treatment of cerebral aneurysms. As always, I encourage you to review these papers in detail in addition to listening to our podcast today. My guest on the podcast today is the Chairman of Neurology at the University of Athens, Dr. Georgios Tsivgoulis. He joins me all the way from Greece to talk about cerebral amyloid angiopathy-related inflammation, or CAA-ri. He's a remarkable researcher, and I can say with absolute confidence that we cannot find a better summary of this very tough topic elsewhere. He ends the interview with an intriguing account of the early description of dementia in Greek mythology. But first, with these two articles. What are covert brain infarcts, or CBIs? Are these the John Wick or the James Bond of the stroke world? After all, they operate undercover. They're ominous and attack without warning. That's probably why they're also called silent infarcts. Now, whatever we call them, we need to know how prevalent they are and what does their presence actually mean. Let's dive into this topic. For at least two centuries, if not longer, we've known about covert brain infarcts. Early description of these lesions is credited to Amédée Dechambre, a medical intern at Salpêtrière Hospital in Paris who noted that there are strokes that can cause symptoms like hemiplegia, but also strokes that are asymptomatic, or so he thought at the time. In the modern times, while we agree with our pathology forefathers that CBIs are different from symptomatic strokes, we also know that they are not entirely asymptomatic. The symptoms can be subtle and tend to sneak up on the patient, but what is clear is that amassing of covert brain infarcts results in an overall decline in cerebrovascular reserve of the brain. With the advent of neuroimaging, we now know that CBIs are age-dependent and prevalent, seen in almost 10 to 30% of even healthy adults, but much more prevalent in those with vascular risk factors, and they can be caused by nearly the entire spectrum of neurovascular disease, including large vessel, small vessel disorders, cardioembolism, and others. Now, how do these covert infarcts catch up in those with atrial fibrillation? Neuroimaging studies have shown that patients with A-fib, especially those untreated, have a higher percentage of embolic-appearing CBIs, and conversely, those with embolic formed pattern of CBIs are more likely to have undiagnosed A-fib. So the question is, what's the significance of CBI in those with confirmed A-fib? In this issue of the journal, Dr. Do Yeon Kim from Seoul National University and colleagues help us answer this question using the EAST-AF, which stands for East Asian Ischemic Stroke Patients With Atrial Fibrillation Study. So, the paper included over 1300 patients with A-fib and first-ever stroke without a prior history of TIA or stroke. And then they categorized these patients into those who had evidence of CBI on neuroimaging and those who didn't. So, what did they find? Forty-two percent of patients with A-fib and first-ever stroke had evidence of covert brain infarcts on neuroimaging. Let's think about it for a moment. These patients presented with what was thought to be their first-ever stroke, not knowing they already had some in their brain. Now, what makes things really worse is that over a quarter of these subjects had more than just one covert infarct. Not surprisingly, those with CBI tended to be older, had higher blood pressure, and had worse white matter hyperintensity burden. This is kind of expected and also not expected was the fact that most of these covert infarcts were actually embolic in pattern. Over 60% of them were embolic. Another 14% of cases had combined embolic and non-embolic-appearing CBIs. Now, overall, the one-year incidence of ischemic stroke and all-cause mortality was higher in those that had CBIs at baseline. When they started looking at the specific patterns of CBIs, those embolic-appearing CBIs had a threefold higher risk of recurrent ischemic stroke, whereas those with non-embolic-appearing covert infarcts had oddly a higher all-cause mortality rate but not recurrent ischemic stroke. And finally, just briefly, the authors noted that the addition of CBIs to the classic CHA2DS2-VASc score didn't meaningfully otherwise statistically improve the scoring metrics, so they left it at that. So, the take-home message is that 42% of A-fib patients presenting with first-ever stroke actually had prior strokes without even knowing based on this study. And most of these strokes were embolic-appearing, and these covert brain infarcts can be used as predictors of future clinical strokes in this population. Strokes should be the last thing to worry about when we think of pregnancy. In the United States, around 30 in 100,000 women, unfortunately, experienced a stroke during pregnancy, and between 6 to 8 in 100,000 deliveries are complicated by subarachnoid hemorrhage. What's the most common cause of pregnancy-associated subarachnoid hemorrhage? In the general population, close to 80% of subarachnoid hemorrhage cases are aneurysmal. Is this true for the pregnant population as well? And importantly, what's the contemporary incidence trend, risk factors, and outcomes of pregnancy-related subarachnoid hemorrhage? In this issue of the journal, Dr. Korhonen and Petra [Ijäs] and their colleagues from the Departments of Neurology and Obstetrics and Gynecology at Helsinki University Hospital will give us the answers to some of these questions through a nationwide population-based study in Finland. So, they looked at over one and a half million pregnant women who gave birth during a 30-year time period between 1987 to 2016. Subarachnoid hemorrhage was identified through appropriate ICD codes and then further adjudicated based on confirmatory information, including neuroimaging and data from lumbar puncture. A total of 57 cases of pregnancy-related subarachnoid hemorrhage was identified in this paper. The mean age of women was 33, ranging from 23 to 45, and the clinical presentation was typical for subarachnoid hemorrhage, including thunderclap headache and mild neurological symptoms. So, what did they find? So, first off, in terms of general observations, the overall incidence rate of pregnancy-related subarachnoid hemorrhage in this study was 3 over 100,000 deliveries. This is almost half the incidence rate reported from the nationwide registries in the United States. Seventy-seven percent of pregnancy-related subarachnoid hemorrhage cases were aneurysmal, so very similar to the general population. The other 23% were non-aneurysmal cases, but it's important to note that 40% of those non-aneurysmal cases also had vascular etiologies, so etiologies such as moyamoya syndrome, postpartum angiopathy, AVM, to name a few. Like non-pregnant patients with subarachnoid hemorrhage, the aneurysmal cases were sicker patients in general. They had a lower GCS at presentation, higher Hunt and Hess scores, and required more ICU admissions. The next finding is very important because it actually shows that development of subarachnoid hemorrhage during pregnancy significantly impacted obstetrical care. A total of 66% of women with subarachnoid hemorrhage during pregnancy ended up having a C-section and a high percentage of these cesarean sections were actually elective. This is in contrast with subarachnoid hemorrhages in the postpartum period where 67% of women had spontaneous vaginal deliveries. The other important finding of the paper was really highlighting the differences between pregnancy-related aneurysmal versus non-aneurysmal subarachnoid hemorrhages. We already talked about how, in general, aneurysmal cases had more severe neurological presentations, so, not surprisingly, they also had worse outcomes with a mortality rate of 16% for the aneurysmal subarachnoid hemorrhage cases, and only 68% of women with pregnancy-related aneurysmal subarachnoid hemorrhage reached a favorable outcome, which was defined in this study as modified Rankin Scale of 0 to 2. Other important differences included the fact that the incidence of aneurysmal subarachnoid hemorrhage increased towards the end of pregnancy and was highest in the third trimester. This ties in with the findings from prior studies all indicating that rupture of an aneurysm is most common in the third trimester. By contrast, the incidence of non-aneurysmal subarachnoid hemorrhage peaked in the second trimester in this study. And finally, in terms of risk factors, first let's talk about age. The incidence rate of pregnancy-associated subarachnoid hemorrhage increased with age of the mother. So, in this study, there were no cases noted amongst women aged below 20 years of age to an incident rate of 12 per 100,000 deliveries among women aged 40 years or over. So that's a fourfold increase from the overall incidence rate of pregnancy-related subarachnoid hemorrhage, and very important point that we learned from this paper. Apart from age, smoking beyond 12 weeks of gestation and hypertension were also independent factors associated with pregnancy-related subarachnoid hemorrhage. So, overall, hypertension, smoking are bad and are significant risk factors for pregnancy-related subarachnoid hemorrhage. And if we have to remember just one thing from this paper, let it be this one: The rupture of an aneurysm is most common in the third trimester of pregnancy. Cerebral amyloid angiopathy, or CAA, is an important cause of intracranial hemorrhage and refers to deposition of β-amyloid fibrils in the wall of the small- and medium-sized cerebral blood vessels, mostly involving cortical and leptomeningeal arteries. It is believed that the deposition of β-amyloid results in architectural disruption of the blood vessels, which then leads to perivascular leakage. That's the pathophysiological mechanism behind the development of cerebral microbleeds. And this process, of course, can cause frank vascular rupture resulting in cortical intracerebral hemorrhage or development of high-convexity subarachnoid hemorrhages. It is important to note that varying amounts of perivascular inflammation, that is inflammation surrounding β-amyloid-laden blood vessels, may be present in some CAA cases, rendering them the designation of inflammation-related CAA. However, frank vasculitic destruction of the vessel wall, such as what is found in amyloid-β-related angiitis, or ABRA, and primary angiitis of the central nervous system, is usually absent in most CAA-related inflammation cases. How these entities are best defined, diagnosed, and treated is subject of intense research. In this issue of the journal, in the study titled "Clinical, Neuroimaging, and Genetic Markers in CAA-Related Inflammation," Dr. Georgios Tsivgoulis and colleagues take us through a systematic review and meta-analysis of published studies of patients with CAA-related inflammation. I am joined today by Dr. Tsivgoulis himself to discuss this paper. He's a Professor of Neurology and Chairman of the Second Department of Neurology at the University of Athens School of Medicine. Dr. Tsivgoulis is the residency program director and the director of cerebrovascular fellowship program with extensive research and expertise in the field of stroke. Good morning, Georgios, and welcome to our podcast. Dr. Georgios Tsivgoulis: Good morning, Negar. I'm delighted to be here and delighted to present our findings, on behalf of all our co-authors. Dr. Negar Asdaghi:         Thank you very much for being here and congrats again on the paper. So, Georgios, let's start with this interest that's going on with using clinical and radiographic features to make the diagnosis of CAA-related inflammation in contrast to moving ahead and performing brain biopsy. Can you please start us off with a brief review of the newly proposed clinico-radiographic criteria for this condition, please? Dr. Georgios Tsivgoulis: Yes. As you mentioned, Negar, CAA-ri is a distinct, however, rare subset of cerebral amyloid angiopathy. Firstly, Greenberg and the Boston group published in Neurology in 2007 a paper highlighting that a diagnosis of a probable CAA-ri patient could be made on the basis of characteristic clinical and neuroimaging findings without requiring a biopsy. Following this observation, Chung and colleagues in 2010, in a seminal paper in JNNP, proposed the first diagnostic criteria for probable and definite CAA-ri. For the definite diagnosis, besides the typical clinical presentation with headache, encephalopathy, focal neurological signs and seizures, and the characteristic neuroimaging findings with T2 or FLAIR hyperintense asymmetric white matter lesions complicated with microbleeds and leptomeningeal or parenchymal gadolinium enhancement, and histopathological confirmation with amyloid deposition within cortical leptomeningeal vessels associated with perivascular, transmural or intramural inflammation was also required. The latest criteria developed in 2015 by Auriel and colleagues that were published in JAMA Neurology using a validation study modified the current criteria for the diagnosis of CAA-ri. In this paper, the author supported the use of empirical immunosuppressive therapy, avoiding brain biopsy, for patients meeting the criteria proposed for probable CAA-ri. They suggested that a brain biopsy should be considered in empirically treated patients who failed to respond to corticosteroid therapy within three weeks. The criteria by Auriel and colleagues are widely applicable in everyday clinical practice, and we also use this criteria for the inclusion of studies in our current meta-analysis. I would like to highlight for our audience that the latest criteria for CAA-ri were published in 2015 by Auriel and colleagues. However, these are different for the criteria for cerebral amyloid angiopathy than the latest criteria were published in 2022 in Lancet Neurology, OK? Dr. Negar Asdaghi:         Georgios, that was a great start for this interview. You had mentioned a lot of information here. I just want to highlight what you just said. So, we are using for this meta-analysis, the latest criteria in CAA-related inflammation published in JAMA by Auriel and colleagues. That's slightly different than, we're not referring to the 2022 criteria of cerebral amyloid angiopathy. It's an important distinction. We're going to talk about this a little more as we go through the interview, but I want to come back to your current paper and start from there. Can you please tell us about the importance of this paper, why doing a meta-analysis was important in your view, and tell us a little bit about the studies that were included in your paper? Dr. Georgios Tsivgoulis: Yes, thank you for that question. CAA-ri is an increasingly recognized entity since the recent diagnostic criteria by Auriel and colleagues published in 2015. In collaboration with the greater availability of the high-resolution MR, we can have now a reliable non-invasive diagnosis of possible or probable CAA-ri, avoiding the risk of brain biopsy. However, I need to highlight that the early diagnosis remains a great challenge for the clinicians and neurologists. Searching the literature, we observe that there is scarce data regarding the prevalence of the distinct clinical, neuroimaging, and genetic markers among patients diagnosed with CAA-ri. We believe that pooling all this information in the current meta-analysis would be very helpful for every clinician, increasing a comprehensive understanding of this rare cerebrovascular disorder. Consequently, we conducted this meta-analysis including 21 studies that recruited a total of 378 patients with CAA-ri. Our study involved only 4 prospective and 17 retrospective hospital-based cohorts of patients diagnosed with CAA-ri based on autopsy or biopsy or on the recent Auriel diagnostic criteria that do not require autopsy or biopsy. Due to limited data in the literature regarding this entity, we had to include only small cohort studies with at least five patients in our meta-analysis. We excluded case reports and case series with less than five patients. This is, by far, the largest available sample of CAA-ri patients in the literature. Dr. Negar Asdaghi:         OK, great. So, let me just recap this, more so for myself. So, we have 21 studies, and you excluded studies that included less than 5 patients. So, practically speaking, case reports. Dr. Georgios Tsivgoulis: Yes, and single-case reports. Dr. Negar Asdaghi:         Yes. And practically speaking, of the total number of patients that are included in this meta-analysis, you have 378 cases, and basically the diagnosis of CAA-related inflammation was either based on the newly proposed criteria or based on biopsy-confirmed or autopsy cases. Dr. Georgios Tsivgoulis: Which is the standard criteria. Dr. Negar Asdaghi:         So, now, I'm dying to ask you about these clinical and radiographic characteristics of patients with CAA-related inflammation in this meta-analysis. Dr. Georgios Tsivgoulis: The mean age of patients in the included studies was approximately 72 years old, and there was no obvious gender predominance. Fifty-two percent of the patients were of female sex. In our study, 70% of the included patients presented with cognitive decline, which was the most common neurological manifestation, while 50% of the total sample had focal neurological signs and 54% encephalopathy presentation. Symptoms such as headache and seizures were less common, 37 and 31% respectively. With regard to the radiological findings, hyperintense T2 FLAIR white matter lesions were very, very common in 98% of our patients, and they were also complicated with lobar cerebral microbleeds, with a prevalence of 96%, and these two were, by far, the most prevalent neuroimaging findings, that white matter hyperintensities coupled with a cerebral microbleed. The pooled prevalence rates of gadolinium-enhanced lesions was 54%, and also the prevalence of cortical superficial siderosis was 51%, which is also very high in this cohort of patients with CAA-ri. Dr. Negar Asdaghi:         OK. So many of the features Georgios said, you mentioned, from presence of white matter hyperintense lesions on T2 FLAIR to presence of cortical microbleeds or superficial siderosis, these features are also seen in patients with cerebral amyloid angiopathy. What are some of the important differentiating features between the two conditions? Dr. Georgios Tsivgoulis: Yes, this is an excellent clinical question. First of all, the lower age threshold for CAA-ri is 40 years old, whereas in cerebral amyloid angiopathy, the lower age threshold is 50 years. So, patients who are younger than 50 years can be diagnosed with CAA-ri, but they cannot be diagnosed with CAA. Another issue is that comparing the result of this meta-analysis with another recent meta-analysis focusing on CAA, on cerebral amyloid angiopathy, that our international multi-collaborative group published in Stroke in 2002, we also evaluated the presence of clinical phenotypes and radiological markers among patients with cerebral amyloid angiopathy. We have documented that transient focal neurological episodes are much more common in patients with cerebral amyloid angiopathy in contrast to patients with CAA-ri. These episodes, which are called TFNEs, transient focal neurological episodes, are attributed to cortical subarachnoid hemorrhage or cortical superficial siderosis. So, I think this is another important clinical distinction. The most important, however, differentiating features between the two entities are neuroimaging markers, in specific, in particular, T2 FLAIR hyperintense unifocal or multifocal lesions with mass effect. These are the most prevalent neuroimaging features among patients with CAA-ri, but they're very seldomly described in patients with cerebral amyloid angiopathy, in patients with CAA. Another characteristic neuroimaging finding very indicative of the inflammation is the leptomeningeal or parenchymal gadolinium enhancement. This finding has been very rarely described in patients with non-inflammatory cerebral amyloid angiopathy. So, the clinical distinction is not so solid. However, the neuroimaging distinction would provide us with very strong information that can help us differentiate these two conditions. Dr. Negar Asdaghi:         Excellent points, I have to say, golden points, not just excellent points. I'm going to try to recap this and see if I understood it correctly. So, for our listeners, we have two conditions that potentially have many common points. One is the cerebral amyloid angiopathy, and the second one, which is obviously the subject of this interview, is cerebral amyloid angiopathy-related inflammation. The most important differentiating factors between the two are actually the neuroimaging features, as Georgios mentioned. So, the first feature that was mentioned is presence of T2 FLAIR hyperintense lesions. Some of them are large and have actually mass effects. This feature is rarely seen in patients with CAA, and it's an important radiographic factor that is seen in patients with CAA-related inflammation. The second distinguishing feature was leptomeningeal enhancement, again, rarely seen in non-inflammatory CAA, but was seen in a significant proportion of patients with CAA-related inflammation. These were the neuroimaging features. You also mentioned two other factors. The median age of CAA-related inflammation was lower than CAA. That can be helpful. And also the entity of transient focal neurological episodes, or TFNE, is rarely seen in inflammatory cases of CAA, whereas it is described in cases with cerebral amyloid angiopathy and mostly related to development of either cortical subarachnoid hemorrhage or cortical superficial siderosis. I think I got this all, correct? Dr. Georgios Tsivgoulis: Excellent. Dr. Negar Asdaghi:         All right, so let's come now to the genetics of CAA. The apolipoprotein E gene is associated with the presence of amyloid angiopathy and development of lobar intracerebral hemorrhage, and we've learned about this in cases with cerebral amyloid angiopathy. Is there an association with ApoE, and did you find anything in this meta-analysis? Dr. Georgios Tsivgoulis: Another very exciting question. In 2007, there was a first report that the apolipoprotein ε4 homozygosity may be considered a risk factor for CAA-ri, and there was a strong correlation reporting a high prevalence of 77% of this apolipoprotein ε4 alleles among patients with CAA-ri. To justify this correlation, the hypothesis was that an underlying pathogenic mechanism, which increases the amyloid-β deposition and has a pro-inflammatory effect, may be suspected as the cause of this disorder. The largest, however, prospective cohort of CAA-ri patients conducted by Antolini and colleagues and was published in 2021 in Neurology, reported a much lower prevalence of apolipoprotein ε4 carriers accounting for 37%, 23% heterozygotes and 14% homozygotes. So, we also documented a pool prevalence of apolipoprotein ε4 homozygosity of 34%. So, we did not confirm the initial finding of 77%. However, in our meta-analysis, the homozygosity was 34%, and we need to have a cautious interpretation of these results because data is limited, and we need larger future population-based studies and in larger cohorts to evaluate the prevalence rate of these specific genetic markers. So, we can confirm an association between apolipoprotein ε4 homozygosity, however not as strong as originally reported in 2007. Dr. Negar Asdaghi:         OK. So, Georgios, thank you. And again, very important factor to keep in mind for our clinicians listening in. Unfortunately, based on what you mentioned, we don't have yet a genetic marker to, for sure, tell us if we're dealing with CAA-related inflammation, yes or no, as you mentioned. Just to recap, earlier on, there was studies to suggest a very strong association between apolipoprotein ε4 homozygosity and CAA-related inflammation. But later on, this was not confirmed by subsequent studies, and in your meta-analysis, you found 34% ApoE ε4 homozygosity amongst patients with CAA-related inflammation and could not confirm that original high association. OK, so with all of that, it's a lot of information. I have to go to the next question regarding controversies involving the levels of Aβ40, Aβ42, and P-tau proteins in CSF in the setting of CAA-related inflammation. Can you please tell us more about these biomarkers? Dr. Georgios Tsivgoulis: Yes. The overlap of Alzheimer's disease and CAA can be attributed to the coexistence of some degree of cerebrovascular amyloid deposition and amyloid plaque pathology, which is very common. And, of course, the evaluation of amyloid and tau proteins in CSF is of high significance for the prognosis and the evolution of CAA patients. In our previous review, we have summarized the literature and noticed that CSF concentrations of Aβ40 and, secondarily, Aβ42 were much lower in patients with cerebral amyloid angiopathy compared with Alzheimer's disease. Total tau and phospho-tau CSF levels were comparable to healthy controls in CAA and lower than patients with Alzheimer's disease. Moving now to CAA-ri, there were scarce data about these biomarkers amongst CAA-ri patients. The majority of the relevant studies have found relatively low levels of Aβ42 and Aβ40 in the CSF and high levels of P-tau. In the present meta-analysis, the pooled means of biomarker levels were based on the findings of only two studies with heterogeneity, and these limit substantially the validity of our observations. However, they confirm the previous reports indicating, as I said before, but I would like to repeat, low levels of Aβ42 and Aβ40 in the CSF and high levels of P-tau. Dr. Negar Asdaghi:         Perfect. So, thank you, Georgios. I'm going to recap what you said. So, we're talking about CSF biomarkers, and first what you mentioned is going back to the original studies concentrated on using these biomarkers as ways of differentiating between cerebral amyloid angiopathy and Alzheimer's disease. And very briefly, to recap what you said, in general, the levels of Aβ40 and, secondarily, Aβ42 was found to be much lower than the Alzheimer's levels in patients with CAA. Now coming to the inflammatory form of CAA, what you mentioned and what you found in this meta-analysis, practically speaking, confirmed that the levels of Aβ40 and Aβ42 in CSF are low and the levels of P-tau are high in this condition as well. So, one thing I want to ask as a secondary question to that is, that it sounds like these biomarkers are more or less similar in CAA and CAA -related inflammation, not that different. Is that correct? Dr. Georgios Tsivgoulis: It's absolutely correct. And I would also like to highlight a major limitation of the meta-analysis that we had available data from only two studies to pool the mean of these CSF biomarker levels. So, these results need to be acknowledged with caution, and we would love to repeat our meta-analysis after the publication of more studies and prospective cohorts measuring the CSF biomarkers in patients with CAA-ri. Dr. Negar Asdaghi:         OK. So, again, important to note, as you mentioned, that there's heterogeneity in data because of just paucity of information on this, but as we stand today, the biomarkers won't really help us in terms of differentiating between the two conditions that are CAA or CAA-related inflammation. And so, I think I've learned a lot from this interview myself, but I think we have to just talk briefly about the available therapies for CAA-related inflammation. Dr. Georgios Tsivgoulis: Yes. In our meta-analysis, we sought to summarize the available information regarding different therapeutic strategies and outcomes among CAA-ri patients. Our results supported our clinical experience indicating that corticosteroids represent the first-line treatment in these patients' outlook. Steroids have been associated with clinical and radiological improvement of the primary disease episode and decreased risk of subsequent relapses in patients with CAA-ri. Additional immunosuppressive therapies, including cyclophosphamide, mycophenolate mofetil, azathioprine, IVIG, or rituximab, have been also reported as adjunct therapies in selected cases with a more severe course of the disease. However, this is another limitation that needs to be acknowledged. That data regarding the treatment and the outcomes are limited and heterogeneous, which prevented us from drawing robust conclusions using a meta-analytical approach. And we believe that we need future cohort studies with prospective data validation in order to generate a proposal for a therapeutic algorithm management in these cases. Dr. Negar Asdaghi:         Thank you, Georgios. So, we have a condition that is now being more and more recognized. We now have criteria based on clinical and radiographic presentation features of patients that might help us with this diagnosis to differentiate it from cerebral amyloid angiopathy. And in terms of therapies, the idea is that the most studied drug is really just first-line therapy, that's corticosteroids. And then there's positive data regarding use of all other forms of immunosuppression, including, as you mentioned, cyclophosphamide, rituximab, and oral agents such as mycophenolate mofetil or azathioprine. We have limited information about those, but I want to highlight something you actually mentioned earlier on in the interview, which is the field is moving towards making these diagnoses based on clinical features and radiographic features that you had highlighted and actually giving patients immunosuppression early on and only move on to a biopsy if the patient had failed these therapies for a period of time, which you mentioned three weeks. So, I think it's important for us as clinicians to keep this evolving criterion and recommendations in mind. And before we end, I want to ask you a hypothetical question, Georgios. In your opinion, what's an ideal randomized trial for CAA-related inflammation in the future? Dr. Georgios Tsivgoulis: I think before going to the randomized, the ideal randomized trial for CAA-ri, and designing this trial, we need much more information regarding the underlying pathophysiological mechanisms. There are many unanswered questions. What is the diagnostic value of CSF biomarkers such as amyloid, we discussed earlier, and tau protein? And, of course, what is the value of CSF and the amyloid-β autoantibodies, if there is any? What is the value of genetic markers such as apolipoprotein E genotype and a correlation with the co-existing inflammation in CAA-ri? However, I don't want to defer this question. So, a typical answer would be that with regard to the ideal patients, we would want a young patient without comorbidities after the first manifestation of CAA-ri who has shown a good clinical and radiological response to corticosteroids in order to define the best second-line therapy. However, before answering all these questions in a clinical trial, if we can, I think that we need to understand the CSF and genetic biomarkers in order to uncover mechanisms regarding pathophysiology that can help us to design more targeted clinical trials studying novel disease-modifying treatments. Dr. Negar Asdaghi:         Thank you. Dr. Georgios, it's been a pleasure having you on the podcast, and I can say we've learned a lot. We look forward to having you back here and talk about that hypothetical randomized trial, and I'm sure one day hopefully will happen in our lifetime. Thank you for being here. Dr. Georgios Tsivgoulis: Thank you. Thank you for having me. It was a pleasure. Dr. Negar Asdaghi:         Thank you. Homer, the legendary Greek poet, described a case of dementia in his seminal work, The Odyssey, in the late eighth century before Christ. He described the cognitive decline of Odysseus's father, King Laertes. The detailed account of the king's mental decline, loss of short-term memory with retention of long-term memory combined with his depression and despair over the loss of his son, is dramatically accurate for a nearly 3,000-year-old description of dementia. Before I ended the interview, I had to use this opportunity to ask Georgios about lessons learned from ancient Greeks and this seemingly timeless disease. Dr. Georgios Tsivgoulis: Thank you for this question. King Laertes was indeed Odysseus's father, and it's a great paradigm describing dementia. However, the ancient history of dementia may be separated according to the Greek philosopher Posidonius in two periods. The first period is called dementia appearing due to old age, which is called in Greek, eros. And the second one is dementia appearing in other ages and mainly due to other reasons, called morosis. Posidonius of Rhodes was a Greek stoic philosopher of the second first century BC who strongly believed and suggested that morosis, which is that dementia appearing in younger ages due to other disorders, should be treated immediately after its onset. So, if I would like to end this podcast, I would just suggest that CAA-ri could be classified as morosis according to Posidonius. And what we could learn is that the early diagnosis is essential since the prompt initiation of corticosteroids should not be unreasonably delayed. Dr. Negar Asdaghi:         And this concludes our podcast for the January 2023 issue of Stroke. Please be sure to check this month's table of contents for the full list of publications, including a series of Focused Updates on post-stroke neurological recovery, from management of post-stroke attention deficit, neglect and apraxia to post-stroke memory decline. And with this, we end the start of our 2023 podcast series. Like all new things, a new beginning can come with new directions, and sometimes a new direction is all that we need. After all, as the legend has it, it was a direction of that falling apple back in the year 1666 that gave Isaac Newton the idea of the universal law of gravitation. Now, Isaac Newton has, without a doubt, given science some of its biggest discoveries in mathematics, physics, and astronomy. But most may not know that Newton had a pretty rough start in life. A January-born premature baby, he was thought not to survive the first few days of life. Newton had a difficult childhood, and at the age of 16, he was pulled out of school by his family and forced to become a farmer, a job he didn't like and he was miserably bad at. So, as we start a new year, let's remember that even the smartest people are not good at everything, and it does take time to find one's passion in life. Now, while things may not always be clear, what is clear is that a great way to find that center of gravity is, as always, staying alert with Stroke Alert. This podcast is produced by Wolters Kluwer and supported by the editorial team of Stroke. Our Stroke Alert podcast and production staff includes Danielle Cross, Eric Goldstein, Nastajjia Krementz, Ishara Ratnayaka, Erinn Cain, Rebecca Seastrong, and Negar Asdaghi. This program is copyright of the American Heart Association, 2023. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, visit AHAjournals.org.

The Scratch Cast: The Alternative Music Podcast
The Scratch Cast - The Alternative Music Podcast - Episode 23: “The Biannual Music Podcast”

The Scratch Cast: The Alternative Music Podcast

Play Episode Listen Later Jan 13, 2023


The Scratch Cast - The Alternative Music PodcastEpisode 23 - “The Biannual Music Podcast”13th January 2022Our first podcast of 2023 is finally here! Full disclosure though, this episode was recorded way back in November, even before the WACO interview (which it took a back seat to). So… expect the digital corkboard and some of our references to specific days, weeks and months to be totally out of date…Given our relaxed release schedule over the course of the last year (something the episode title pokes fun at) this is another bumper submissions episode where we catch up with as much stuff as we can.On this episode, we almost avoid talking about piss, Snedds tells a pointless story about looking for a Post Coal Prom Queen tweet and Grant drops some quiz facts about the musical abilities of Bonnie and Clyde…The digital corkboard returns with releases from “Mothman and the Thunderbirds”, “Voldo” and “Equal Frequencies“. On our singles swap we discuss “Didn't Care” by North Carolina's folktronica duo “Sylvan Esso” and “Let The Lights On” from North London indie rockers “Sorry”. And for our bumper submissions episode we talk about “II/Infinity”, the debut album from experimental electronic pop artist “O-SHIN”, the self-titled EP from Norwegian surf-punk trio “The Bundy Bunch”, “Evidence of a Broken Mind”, the debut album from Utrecht quintet “Two and a Half Girl”, “Endure”, the latest single from Los Angeles psyche-rockers “Magna Zero”, the self-titled EP from Leeds rockers “Radio Aftermath”, and finally “Shadows”, the debut album from Genoese doom metal veterans ”ExpiatoriA”.Sit back, relax and listen to Episode 23: ”The Biannual Music Podcast”.If you want to support the show, you can buy us a coffee here.If you're wondering what our review scores relate to, check out our rating system below:1/10 - Destroy without listening2/10 - Rancid bin juice (bathe afterwards)3/10 - Hot garbage (avoid)4/10 - Meh (not worth going back to)5/10 - Forgettable (one or two good songs)6/10 - Just OK (for fans of the genre)7/10 - Good (quite like it)8/10 - Very good (must listen)9/10 - Exceptional (absolutely love it)10/10 - Practically flawless (unmissable)Don't forget to subscribe to The Scratch Cast on your favourite streaming/podcast service so you never miss an episode. Please leave a nice review :)Spotify: https://spoti.fi/2KYNkI2Apple Podcasts: https://apple.co/3082hBjGoogle Podcasts: http://bit.ly/2QXCohyYouTube: http://bit.ly/2QXtlxoDeezer: http://bit.ly/34sjqDACastbox: http://bit.ly/34sEJoHTuneIn Radio: http://bit.ly/2QVt8ur& more: https://podfollow.com/the-scratch-cast-podcastAll music clips are used as a teaser only and remain the property of the respective artists.Peace.

A Long Time In Finance
Long Time Short: The Dutch Bond That Kept On Giving

A Long Time In Finance

Play Episode Listen Later Jan 11, 2023 13:18


On May 15 1648, the same day Holland signed the Treaty of Munster ending its 80 year war with Spain, a Dutch canal board issued a bond of 1,000 Carolus guilders to a Mr Niclaes de Meijer of Utrecht promising to pay him 5 per interest in perpetuity. In the latest of our Long Time Shorts, Jonathan explains how that promise is still being kept 374 years later, what Mr de Meijer's bond might be worth today, and why the Dutch are so good (relatively speaking) at meeting their financial obligations. Lang leve Nederland!Presented by Jonathan Ford and Neil Collins.Produced and edited by Nick Hilton for Podot.In association with Briefcase.News Hosted on Acast. See acast.com/privacy for more information.

Biceps & Mindset avec Quentin Randis
#109 - La vie aux Pays-Bas en tant que Français, c'est comment ? ft. True Marius

Biceps & Mindset avec Quentin Randis

Play Episode Listen Later Jan 10, 2023 64:20


Episode en voyage aujourd'hui, aux Pays-Bas, plus précisément à Utrecht, chez mon ami True Marius, qui intervient pour la 2ème fois sur le podcast. Explorons ensemble son retour d'expérience après 2 ans d'expatriation dans ce nouveau pays. ⚠️ Le podcast est maintenant disponible en vidéo sur Spotify ! Enjoy :D

Waarheen, Waarvoor
Waarheen, Waarvoor - Heleen Schuttevaêr | NH Radio

Waarheen, Waarvoor

Play Episode Listen Later Jan 8, 2023 61:02


Gast: Heleen Schuttevaêr, muzikant: pianiste en zangeres. Ze komt uit Utrecht, waar ze na haar middelbare school werkzaam was als journalist voor onder andere het Utrechts Nieuwsblad. Ze interviewde David Bowie, Charles Aznavour en Mick Jagger en presenteerde ooit het televisieprogramma 'Twien', een magazine voor tieners en twens dat maandelijks op de vrijdag te zien is geweest. Heleen is ook bekend van de Utrechtse band The Broads. Eind 2022 ze haar eerste boek uit: 'Ik zit hier fantastisch - eenakters aan de bedrand van mijn hoogbejaarde moeder', een boek over ouder worden waar je ook een beetje vrolijk van wordt, 'met een hoofdpersoon die je hart steelt'. Het zijn ruim vijftig eenakters met een glimlach, verbazing of ontroering genoteerd in de laatste levensjaren van haar moeder, die 99 werd.

AD Voetbal podcast
S5E139: 'Ajax heeft van de titelkandidaten de meeste creaviteit in de ploeg'

AD Voetbal podcast

Play Episode Listen Later Jan 8, 2023 54:29


FC Twente is de grote winnaar van de top 5 bij de herstart van de Eredivisie. De ploeg van Jans won als enige. Ajax, PSV, Feyenoord en AZ speelden gelijk. In de AD Voetbalpodcast gaat het over transfers, speelstijlen, kansen creëren of niet, opvallende scheidsrechters en Wout en Erik. Etienne Verhoeff bespreekt het met Mikos Gouka en Maarten Wijffels. De druk zat er bij Ajax goed op bij de eerste wedstrijd van 2023. Maarten Wijffels bezocht het duel voor het AD. ‘NEC-Ajax was een wedstrijd die Ajax normaal gesproken wint. Ik heb de top 5 gezien. Dan heeft Ajax echt de meeste creativiteit en de meeste mogelijkheden om tot een doelpunt te komen. Alleen ze hebben niet gewonnen dit weekend. Daarin viel Schreuder weinig te verwijten.'Gouka: ‘Het sentiment richting Schreuder en Ajax is zo negatief. Die fans willen helemaal niet horen van een trainer dat ze op vijf minuten na prima speelden. Koploper Feyenoord kwam ook niet tot winst, maar speelde gelijk tegen FC Utrecht. Op de achtergrond speelt de mogelijke transfer van FC Twente-middenvelder Zerrouki. De Rotterdammers hebben inmiddels een nieuw bod op hem gedaan. ‘Als FC Twente niet een speler hoeft te verkopen dit jaar voor de boekhouding, dan kan je wachten met die transfer tot de zomer', zegt Mikos Gouka. 'Maar als het nu afketst gaat Feyenoord voor een andere speler. En dan moet je nog maar zien wat er gebeurt.' Wijffels: ‘Dan komt PSV wel voor Zerrouki als vervanger van Sangaré deze zomer. Die krijgt zijn transfer naar de traditionele top drie wel. Voor ons voetbal is het niet goed als spelers van FC Twente een transfer naar Ajax, PSV of Feyenoord overslaan en direct naar het buitenland gaan. Je moet een speler van Twente of Utrecht de kans geven om naar de top drie te gaan.' Beluister de hele podcast via AD.nl, de AD App of jouw favoriete podcastapp. Het laatste sportnieuws lees je in de krant of via https://www.ad.nl/sport/Support the show: https://krant.nlSee omnystudio.com/listener for privacy information.

Oral Arguments for the Court of Appeals for the Seventh Circuit
Amory Investments LLC v. Utrecht-America Holdings, Inc.

Oral Arguments for the Court of Appeals for the Seventh Circuit

Play Episode Listen Later Jan 6, 2023 20:23


Amory Investments LLC v. Utrecht-America Holdings, Inc.

Fiction Lab
Delayed with... Luna Ludmila

Fiction Lab

Play Episode Listen Later Jan 6, 2023 57:26


During our trip to the Netherlands in October, we had an opportunity to meet one of the rising stars from the Dutch underground electronic scene that we've been following for a few years now, Ashley Haak, aka Luna Ludmila. The talented DJ and producer from Utrecht stole our hearts with her warm and friendly attitude, vast music knowledge, and incredible DJ skills. After contributing a track to the 'Nowhere 02' compilation on SoHaSo and remixing Dwaalgast's 'Maan' track, both of which we had the pleasure premiering, Luna Ludmila released an outstanding debut solo EP on Amsterdam-based Statetly Records in June last year. With many local and international gigs, already under her belt, including Loveland Festival, Breakfast Club, Shelter, and Paradigm, to name a few, and her upcoming debut at the infamous Awakenings festival Luna Ludmila is one the bright stars from the vibrating Dutch scene. Luna Ludmila's mix is deep and dubby, blurring the lines between house and techno with excellent track selection and smooth flow. It's the late-night, after-hour vibe in its finest form. @lunaludmila https://www.instagram.com/luna_ludmila_/ www.itsdelayed.com www.instagram.com/_itsdelayed_ www.facebook.com/itsdelayed

De Grote Podcastlas
#50 Moskou

De Grote Podcastlas

Play Episode Listen Later Jan 5, 2023 79:14


Moskou was lange tijd de hoofdstad van het Russische Keizerrijk. Het was de hoofdstad van de Sovjet-Unie en nu van Poetins Rusland. Maar is Moskou nog van de Moskovieten? Na het overzichtelijke Sovjet-leven waarin het meeste niet te koop was, volgden de wilde jaren ‘90 waarin alles te koop leek. Tegenwoordig ís alles te koop in het Moskou van het grote geld. Behalve voor de normale Moskovieten, die we voor het gemak maar even Joeri en Irina noemen. Wie geluk heeft, heeft 30 jaar bouwdrift vóór zich zien werken. Vanuit de luxe woontorens kijk je zo op het Rode Plein. Wie pech heeft, zit nog altijd in zijn Chroesjtsjov-flat waar de verwarming het wel of niet doet. De kosmopolitische oligarchen lopen rondjes door dezelfde parken waar in de lente de doodgevroren zwervers onder de sneeuw vandaan komen, die de Moskovieten ‘sneeuwklokjes' noemen.Moskou is een stad van radicale vooruitgang en oneindige nostalgie tegelijk. Van ongebreideld kapitalisme tot melancholische Sovjet-herinneringen. Dus wat wil een Kleine Podcastlas-stedenspecial nog meer? We zijn nooit volledig, wel origineel. Geen experts, maar wel liefhebbers. Hebben we tóch iets verkeerd gezegd of zijn we iets cruciaals vergeten? Volg ons en laat het weten.Neem vooral ook even een kijkje op onze website.

Kunststof
Joyce Overheul, kunstenaar

Kunststof

Play Episode Listen Later Jan 4, 2023 54:01


Kunstenaar Joyce Overheul selecteerde humoristische werken met maatschappelijke thema's voor de expositie “Het ergste moet nog komen” bij Galerie Larik in Utrecht. Haar eigen werken draaien om onderwerpen als gelijkheid, emancipatie, vrouwenrechten en feminisme. Overheul werd in november benoemd tot ‘Talent van het jaar 2023'. Presentatie: Elisabeth van Nimwegen

Omdenken Podcast
Aflevering 94 - Bindingsangst (2)

Omdenken Podcast

Play Episode Listen Later Jan 2, 2023 39:14


Na aflevering 70 over bindingsangst mailde Sven (33) ons dat hij toch echt een nog groter bindingsangstprobleem heeft. Vier psychologen verder loopt hij nog steeds weg van dates als het te serieus wordt. Hij begrijpt nog steeds niet precies waarom en is de wanhoop nabij, want hij wil ontzettend graag een relatie. In dit gesprek komen Berthold en Sven al snel beknellende gedachten en oorzaken tegen. Zou het genoeg zijn om Sven van zijn jarenlange struggle te bevrijden?Wil jij de Omdenken podcast een keer live bijwonen? Op 11 januari 2023 nemen we de 100e aflevering live op in Theater Oudaen in Utrecht! Jij kunt daarbij zijn. Alle info & kaartverkoop vind je op https://omdenkenpodcast.eventbrite.com/En ben jij nou benieuwd hoe het nu is met de gasten uit onze podcast? Kijk dan op omdenken.nl/hoeishetnumet om hun updates te lezen.

Beyond Boards
Episode 39 - Imke Leerink

Beyond Boards

Play Episode Listen Later Jan 2, 2023 100:46


Episode 39 with Imke Leerink, skateboarder, social media and marketing manager from The Hague, Holland, founder of Girls Shred.  Together we discussed her growing up and picking up a board in Utrecht, starting a myspace account called « Girls Shred » back in 2007 to connect with girl skaters near her, moving over to Facebook and Instagram to keep developing the community worldwide, doing events, meet-ups and workshops, the gnarly knee injuries she went through and is still struggling with to a certain extent, running the Instagram account daily, going to the 2019 edition of Pushing Boarders at Bryggeriets Gymnasium in Malmö, the place of women in skateboarding, the future of social media…    Intro (00:13)  Getting started (01:13)  First inspirations, first videos (04:49)  Working in graphic design (11:38)  Starting Girls Shred on Myspace (13:36)  Injuries (19:13)  Girls Shred moving to Instagram and next steps (39:56)  Events and meet-ups (43:47)  Running the IG account (51:21) Place of women in skateboarding (59:57) « Death » of social media (01:10:06)  Most valuable lesson learned from skateboarding (01:15:13)  Friends questions (01:15:53)  Conclusion (01:40:08)   For more information and resources: https://linktr.ee/beyondboards 

SWR2 Impuls - Wissen aktuell
Fahrrad-Paradies Utrecht – grüne Radwege und Radparkhaus

SWR2 Impuls - Wissen aktuell

Play Episode Listen Later Dec 30, 2022 4:58


Radfahren in der Stadt kann die pure Entspannung sein – wenn die Infrastruktur stimmt. Im niederländischen Utrecht ist das besonders gelungen, nicht zuletzt durch der Umwandlung der mehrspurigen Stadtautobahn in einen grünen Radweg – und der grünen Weller für Radler.

De Grote Podcastlas
#49 New York City

De Grote Podcastlas

Play Episode Listen Later Dec 29, 2022 86:40


‘If I can make it there, I can make it anywhere'. Frank Sinatra, 11 woorden, de onbegrensde mogelijkheden van New York City. De ongekroonde hoofdstad van de wereld. New York is het zenuwcentrum van de wereldeconomie, het kloppende hart van de culturele globalisering. Haar aderen zijn de brede avenues, de waterwegen en de metro waardoor elke dag meer mensen stromen dan er in Nederland wonen. En het is een bont gezelschap.Of je nou Noord-Nepalees of Zuid-Zimbabwaans wil eten, er is vast een speciale wijk voor. Want niet alleen krijgt de wereld elke dag New York voorgeschoteld, maar New York krijgt ook al eeuwenlang de hele wereld op bezoek. Als wij als mensheid een antropologische Ark van Noach zouden moeten samenstellen, zouden we bijna alleen maar in New York hoeven te shoppen. Als ‘the American dream' nog levend is, vind je hem hier. Van sappelende bijstandsmoeders in The Bronx tot Jiddisch babbelende ultra-orthodoxen in Brooklyn. Van ‘greed is good' aan Wall Street tot spaghetti meatballs in Little Italy. Iedereen is onderweg op de ladder van de welvaart. Allemaal verenigd onder een knipoog van de dame op het Vrijheidsbeeld.We zijn nooit volledig, wel origineel. Geen experts, maar wel liefhebbers. Hebben we tóch iets verkeerd gezegd of zijn we iets cruciaals vergeten? Volg ons en laat het weten.Neem vooral ook even een kijkje op onze website.

Omdenken Podcast
Aflevering 93 - Ik wil afvallen maar het lukt niet

Omdenken Podcast

Play Episode Listen Later Dec 26, 2022 36:13


Voor Christine (41) is haar gewicht al zeker 30 jaar een thema. Ze heeft altijd het gevoel te dik te zijn. Maar elke keer als ze probeert af te vallen, wil ze juist alles eten wat los en vast zit. Daarnaast vindt ze het vervelend dat eten überhaupt zo'n obsessie is. Ze zou zo graag gewoon een gezonde relatie met eten willen hebben. In dit gesprek komen Berthold en Christine erachter dat er veel meer diepere lagen onder het zelfbeeld 'te dik' liggen, zoals het gevoel niet leuk te zijn en er niet bij te horen. Wil jij de Omdenken podcast een keer live bijwonen? Op 11 januari 2023 nemen we de 100e aflevering live op in Theater Oudaen in Utrecht! Jij kunt daarbij zijn. Alle info & kaartverkoop vind je op https://omdenkenpodcast.eventbrite.com/En ben jij nou benieuwd hoe het nu is met de gasten uit onze podcast? Kijk dan op omdenken.nl/hoeishetnumet om hun updates te lezen.

Boekestijn en De Wijk | BNR
Geopolitiek 2022

Boekestijn en De Wijk | BNR

Play Episode Listen Later Dec 24, 2022 23:41


Poetin, Xi en Johann Sebastian Bach: een impressie van de Boekestijn en De Wijk Geopolitieke Eindejaarsshow, live in Tivoli, Utrecht.See omnystudio.com/listener for privacy information.

Active Towns
The Real Bicycle Mayor w/ John Bauters (video available)

Active Towns

Play Episode Listen Later Dec 24, 2022 58:52


Watch the video version of this episode to get the full effect.Helpful Links (note that some may include affiliate links to help me support the channel):- Mayor Bauters on Twitter- John and Chris Bruntlett riding in Utrecht  - Streetfilms video profiling John's visit to NYC- Propel Bikes - Chris Nolte's ride w/ John- The Study Tour DCE Publication- The Outspoken Mayor interview- National Association of City Transportation Officials (NACTO)- Cul de Sac Tempe- My episode w/ Toronto Bicycle Mayor, Lanrick Bennett, Jr.- My episode with Chris Nolte- My episode with Jill Warren- My playlist of Austin's Dutch Inspired Bike NetworkFour Easy Steps to Support My Efforts:1. Become an Active Towns Ambassador by "Buying Me a Coffee" or by pledging as little as $1 per month on Patreon2. If you enjoyed this episode, please give it a "thumbs up," leave a review on Apple Podcasts, and share it with a friend.3. Subscribe to the podcast on your preferred listening platform and the Active Towns YouTube Channel4. Pick up some Active Towns #StreetsAreForPeople Merch at my storeCredits:All video and audio production by John SimmermanMusic:Epidemic SoundResources used during the production of this episode:- My awesome recording platform is Ecamm- Adobe Creative Cloud SuiteFor more information about my Active Towns effort or to follow along, please visit my links below:- Website- Twitter- Newsletter- Podcast landing pages- Facebook- InstagramBackground:Hi Everyone, my name is John Simmerman.I'm a health promotion professional with over 30 years of experience and my area of concentration has evolved into a specialization of how the built environment influences human behavior related to active living and especially active mobility.In 2012 I launched the non-profit Advocates for Healthy Communities as an effort to help promote and create healthy, active places.Since that time, I've been exploring, documenting, and profiling established, emerging, and aspiring Active Towns wherever they might be, in order to produce high-quality multimedia content to help inspire the creation of more safe and inviting, environments that promote a "Culture of Activity" for "All Ages & Abilities."My Active Towns suite of channels feature my original video and audio content and reflections, including a selection of podcast episodes and short films profiling the positive and inspiring efforts happening around the world as I am able to experience and document them.Thanks for tuning in; I hope you have found this content helpful.Creative Commons License: Attributions, Non-Commercial, No Derivatives, 2022Advocates for Healthy Communities, Inc. is a nonprofit 501c3 organization (EIN 45-3802508) dedicated to helping communities create a Culture of Activity. To donate, click here. ★ Support this podcast on Patreon ★

De Grote Podcastlas
#48 Maleisië

De Grote Podcastlas

Play Episode Listen Later Dec 22, 2022 87:34


Zeg je Maleisië, dan zeg je Kuala Lumpur, en dan zeg je de Petronas Twin Towers. Hadden die gestaan voor de twee delen waar Maleisië uit bestaat, dan hadden we je geloofd. Maar helaas - gemiste kans. Wij zijn fan van stedenrivaliteiten binnen een land. 010 vs 020, Lissabon vs. Porto. Yaoundé vs. Douala. Sydney vs. Melbourne. Maar een land dat bestaat uit zulke gelijkwaardige delen, dat hebben we nog niet gezien. Eiland tegenover schiereiland. Het één heeft meer natuur, het ander meer bevolking. Het één is economisch sterker, het ander is groter. Maar laten we alvast zeggen: beide delen zijn de moeite waard. Beeldschoon, complex en kruidig. Welkom, in Maleisië!We zijn nooit volledig, wel origineel. Geen experts, maar wel liefhebbers. Hebben we tóch iets verkeerd gezegd of zijn we iets cruciaals vergeten? Volg ons en laat het weten.Neem vooral ook even een kijkje op onze gloednieuwe website.

FC Afkicken
'PSV heeft John de Jong een mes in de rug gestoken'| FCA Daily #83

FC Afkicken

Play Episode Listen Later Dec 21, 2022 42:29


In de dagelijkse podcast van FC Afkicken bespreken Lars Jesse van Eijden, Lars van Velsum en Wouter Boerkamp op woensdag 21 december onder meer het interview van John de Jong over zijn vertrek bij PSV, de situatie bij Manchester United, de zoektocht van FC Groningen en FC Utrecht naar een nieuwe trainer en het balletje rolt weer!(01:30) John de Jong spreekt zich uit(14:52) Trainers gezocht bij Groningen en Utrecht(24:22) Ten Hag bouwt bij Manchester United(30:36) Sterren vertrekken(34:42) De bal rolt alweerZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.

Zakendoen | BNR
Ewald Dudok (Dudok) over de verkoop van familiebedrijf Peute

Zakendoen | BNR

Play Episode Listen Later Dec 16, 2022 111:12


Ewald Dudok maakte het afvalrecyclingbedrijf van zijn vader groot en verkocht het vervolgens om zijn droom in de vastgoedwereld waar te maken. Inmiddels heeft hij het in de Quote 500 geschopt. Is dit iets om trots op te zijn of schaamt hij zich voor deze notering? Macro met Mujagić Elke dag een intrigerende gedachtewisseling over de stand van de macro-economie. Op maandag en vrijdag gaat presentator Thomas van Zijl in gesprek met econoom Arnoud Boot, de rest van de week praat Van Zijl met econoom Edin Mujagić. Ondernemerspanel Door de inflatie en hoge energiekosten overwegen veel ondernemers te stoppen. En: De curator van NXT Fashion, het moederbedrijf van modeketens Miss Etam en Steps, heeft eigenaar Martijn Rozenboom voor de rechter gedaagd. Dat en meer bespreken we om 13.00 in het ondernemerspanel met: - Elske Doets, eigenaar van Doets Reizen - Joyce Knappe, oprichter van ProParents Luister | Ondernemerspanel Pitches Elke vrijdag is het weer tijd voor jonge ondernemingen om zichzelf op de kaart te zetten. Dat doen zij via een pitch en het doorstaan van een vragenvuur. Vandaag is het de beurt aan Hüseyin Yildiz, oprichter van Onproad en Tarik Kabdani, oprichter van Bezorging met liefde. Cilian Jansen van Karmijn Kapitaal zal de startups beoordelen en van advies voorzien. Zakenpartner Ze volgde de university college in Utrecht, ging aan de slag als journalist maar wilde toch liever met tastbare producten werken. Daarom volgde ze een traineeship bij Ahold. Op de supermarktvloer zag ze hoeveel eten er verspild werd, dit bracht haar op het idee een restaurant te openen wat gebruik maakt van voedsel dat anders zou worden weggegooid. Dit was de start van Instockmarket. De zakenpartner deze week is Selma Seddik mede-oprichter van Instockmarket. Contact & Abonneren BNR Zakendoen zendt elke werkdag live uit van 12:00 tot 14:30 uur. Je kunt de redactie bereiken via e-mail en Twitter. Abonneren op de podcast van BNR Zakendoen kan via bnr.nl/zakendoen, of via Apple Podcast en Spotify.See omnystudio.com/listener for privacy information.

Zakendoen | BNR
Ed Bindels (Amac) over chips en stakingen

Zakendoen | BNR

Play Episode Listen Later Dec 15, 2022 110:45


Appleverkoper Amac heeft last van de wereldwijde chiptekorten. En ook de stakingen in iPhone-fabriek Foxconn in China hebben een negatieve invloed op de omzet. En: als erkende verkoper van het merk heb je óók te maken met de bazen in Cupertino. Hoe ga je daar als ondernemer mee om? Topman Ed Bindels van Amac is te gast in BNR Zakendoen. Macro met Mujagić  Elke dag een intrigerende gedachtewisseling over de stand van de macro-economie. Op maandag en vrijdag gaat presentator Thomas van Zijl in gesprek met econoom Arnoud Boot, de rest van de week praat Van Zijl met econoom Edin Mujagić. Boardroompanel Wat doe je als topman van ASML als een oud-werknemer bedrijfsgeheimen steelt en vervolgens een concurrerend bedrijf opricht? En: hoe ga je als organisatie om met discriminatie op de werkvloer? Dat en meer bespreken we om 13.00 in het boardroompanel met: Tanja Nagel, bestuursvoorzitter van DSI, en commissaris bij diverse organisaties Anton Wiggers, partner bij Themis Company en bedrijvendoktor Inzicht De rol van finance professionals is sterk aan het veranderen. Dat blijkt uit onderzoek van Financefactor en Zipconomy onder hoog opgeleide finance professionals. Hoe spelen ze in op groeiende ontwikkelingen als digitalisering? En: welke vaardigheden horen daar eigenlijk bij? Te gast is Albert Allmers, directeur en oprichter van FinanceFactor.  Zakenpartner Ze studeerde aan het University College in Utrecht, ging aan de slag als journalist maar wilde toch liever met tastbare producten werken. Daarom volgde ze een traineeship bij Ahold. Op de supermarktvloer zag ze hoeveel eten er verspild werd. Dit bracht haar op het idee een restaurant te openen wat gebruik maakt van voedsel dat anders zou worden weggegooid. Dit was de start van Instockmarket. De zakenpartner deze week is Selma Seddik, mede-oprichter van Instockmarket.  Contact & Abonneren BNR Zakendoen zendt elke werkdag live uit van 12:00 tot 14:30 uur. Je kunt de redactie bereiken via e-mail en Twitter. Abonneren op de podcast van BNR Zakendoen kan via bnr.nl/zakendoen, of via Apple Podcast en Spotify.See omnystudio.com/listener for privacy information.

De Grote Podcastlas
#47 Djibouti

De Grote Podcastlas

Play Episode Listen Later Dec 15, 2022 44:15


Op het eerste gezicht is Djibouti niet het mooist glimmende beeldje in de vitrine van wereldlanden. Ze staan niet met een obscure cultheld in de Top 2000, ze leveren geen legendarische voetballers, en ook de wereldkeuken kan wel zonder Djibouti. Dus jij denkt vast dat wij met tegenzin onderzoek hebben zitten doen naar een landje dat misschien alleen hoog eindigt op lijstjes van saaiste landen. Dan zit je er vrij ver naast.Djibouti is namelijk de brugwachter van de wereldscheepvaart. Heb je tijdens het bootjevaren wel eens een ijsje gekocht uit de tuin van iemand die pal naast het sluisje woont? En ben je er even voor 50 cent naar de WC geweest? Dat, lieve luisteraars, heeft Djibouti rijk gemaakt. En machtig, maar daarover later meer.We zijn nooit volledig, wel origineel. Geen experts, maar wel liefhebbers. Hebben we tóch iets verkeerd gezegd of zijn we iets cruciaals vergeten? Volg ons en laat het weten.Neem vooral ook even een kijkje op onze gloednieuwe website.

Zakendoen | BNR
Janine Luten (GroentenFruit Huis) over de lobby voor 0 procent btw

Zakendoen | BNR

Play Episode Listen Later Dec 14, 2022 109:58


Waarom kan de btw op groente en fruit er pas in 2024 van af? EN: hoeveel impact heeft de Brexit nog op de groente- en fruitsector? Te gast is Janine Luten, algemeen directeur van brancheorganisatie GroentenFruit Huis.  Macro met Mujagić Elke dag een intrigerende gedachtewisseling over de stand van de macro-economie. Op maandag en vrijdag gaat presentator Thomas van Zijl in gesprek met econoom Arnoud Boot, de rest van de week praat Van Zijl met econoom Edin Mujagić. Lobbypanel Het Europees Parlement wordt in zijn greep gehouden door een groot corruptieschandaal. Is het tijd om de lobbyregels in Brussel stevig aan te scherpen? En: Gasunie pleit voor meer lng-terminals in Nederland, máár daar hebben ze wel een flinke overheidsgarantie voor nodig.Dat en meer bespreken we in het Lobbypanel met: - Maria van der Heijden directeur van MVO Nederland; - Mark van den Anker, mede-eigenaar van Wepublic Luister | LobbypanelDe Veranderaars In de interviewserie ‘De Veranderaars' gaat Thomas van Zijl elke woensdag in gesprek met leiders die de digitale transformatie van Nederland vormgeven. Ik vraag hen naar de technische oplossingen, maar óók naar hun visie op leiderschap in het digitale tijdperk. Het ziekteverzuim bereikte dit jaar een recordhoogte van 6,3%. Wat mag en kan een werkgever doen om te voorkomen dat een groot deel van het personeel ziek thuis zit? Te gast is Suzanne van Pelt, oprichter van Smart Health. Zakenpartner Ze studeerde aan het University College in Utrecht, ging aan de slag als journalist maar wilde toch liever met tastbare producten werken. Daarom volgde ze een traineeship bij Ahold. Op de supermarktvloer zag ze hoeveel eten er verspild werd. Dit bracht haar op het idee een restaurant te openen wat gebruik maakt van voedsel dat anders zou worden weggegooid. Dit was de start van Instockmarket. De zakenpartner deze week is Selma Seddik, mede-oprichter van Instockmarket.  Contact & Abonneren BNR Zakendoen zendt elke werkdag live uit van 12:00 tot 14:30 uur. Je kunt de redactie bereiken via e-mail en Twitter. Abonneren op de podcast van BNR Zakendoen kan via bnr.nl/zakendoen, of via Apple Podcast en Spotify.See omnystudio.com/listener for privacy information.

Zakendoen | BNR
Frank Vosselman (De Bolster) over de overstap naar coöperatie

Zakendoen | BNR

Play Episode Listen Later Dec 13, 2022 108:51


Biologische zaadveredelaar De Bolster, gaat als coöperatie verder om groeikapitaal bij klanten, leveranciers en investeerders op te halen. Wat betekent dat voor de bedrijfsvoering van het familiebedrijf? Frank Vosselman, topman van De Bolster, is te gast in BNR Zakendoen. Macro met Mujagić Elke dag een intrigerende gedachtewisseling over de stand van de macro-economie. Op maandag en vrijdag gaat presentator Thomas van Zijl in gesprek met econoom Arnoud Boot, de rest van de week praat Van Zijl met econoom Edin Mujagić. Beleggerspanel Pensioenfonds ABP heeft olieaandelen ingekocht terwijl het vorig jaar aankondigde uit fossiele beleggingen te stappen En: Het Amerikaanse farmabedrijf Amgen neemt branchegenoot Horizon over. Dat en meer bespreken we  in het beleggerspanel met: - Marco Groot, partner bij consultant 8 Days a Week - Corné van Zeijl, analist en strateeg bij vermogensbeheerder Actiam. Luister l Beleggerspanel Inzicht Nederlandse technologiebedrijven zijn niet blij met toenemend toezicht op Chinese investeringen. Begin volgend jaar treedt er een nieuwe wet in werking waarmee de overheid investeringen kan toetsen die te maken hebben met gevoelige technologie. Bij ons te gast is vandaag Boudewijn Poldermans, sinoloog en vicevoorzitter van de Netherlands China Business Council Zakendoen over de grens Onder leiding van Liesje Schreinemacher, Minister voor Buitenlandse Handel en Ontwikkelingssamenwerking zal er van 13 tot en met 17 maart een handelsmissie naar Zuid-Korea en Japan plaatsvinden. Beide landen bieden veel kansen voor Nederlandse ondernemers, met name op het gebied van innovatie en technologie. Bij ons te gast is Tjerk Opmeer, directeur Internationaal Ondernemen, RVO. Zakenpartner Ze studeerde aan het University College in Utrecht, ging aan de slag als journalist maar wilde toch liever met tastbare producten werken. Daarom volgde ze een traineeship bij Ahold. Op de supermarktvloer zag ze hoeveel eten er verspild werd. Dit bracht haar op het idee een restaurant te openen wat gebruik maakt van voedsel dat anders zou worden weggegooid. Dit was de start van Instockmarket. De zakenpartner deze week is Selma Seddik, mede-oprichter van Instockmarket. Contact & Abonneren BNR Zakendoen zendt elke werkdag live uit van 12:00 tot 14:30 uur. Je kunt de redactie bereiken via e-mail en Twitter. Abonneren op de podcast van BNR Zakendoen kan via bnr.nl/zakendoen, of via Apple Podcast en Spotify.See omnystudio.com/listener for privacy information.

Startup Insider
Investments & Exits - mit Otto Birnbaum von Revent

Startup Insider

Play Episode Listen Later Dec 13, 2022 16:21


Das Münchner Unternehmen Pacifico Energy schließt sich mit der Eiffel Investment Group zusammen, um die Entwicklung von Projekten im Bereich der erneuerbaren Energien zu beschleunigen und ihre Ressourcen zu bündeln. Sie umfasst eine Vereinbarung über die Zusammenarbeit sowie eine Investition in Höhe von 20 Millionen Euro. Pacifico Energy Partners wurde 2016 gegründet und entwickelt zukunftsweisende Lösungen für Wind- und Solarenergie sowie Batterie- und Wasserstofftechnologien. Mit dieser Beteiligung konzentriert sich das in München ansässige Unternehmen auf die Entwicklung eines Portfolios von Agri-Photovoltaik-Projekten in Italien, hauptsächlich in der Region Latium, mit einer Gesamtleistung von ca. 300 Megawatt. Der Anbieter für elektronische Lastenräder Cargoroo hat 10 Millionen Euro in einer Finanzierungsrunde erhalten. Das Cargoroo-Sharing-Konzept wurde in Eindhoven eingeführt und wird bald auch in Amsterdam, Utrecht, Den Haag, Nijmegen und Arnheim zu finden sein. Außerhalb der Niederlande ist Cargoroo in Antwerpen und Berlin auf dem Vormarsch. Die neue Finanzierung wird die bestehenden Märkte erweitern sowie einen französischen Markteintritt ab Lyon ermöglichen. Die Runde wurde von The Sharing Group und Participatiefonds Duurzaam Economie Noord-Holland (PDENH) getätigt, die sich den bestehenden Investoren Fairtree und Elevant Ventures anschließen.

Zakendoen | BNR
Clayde Menso (Internationaal Theater Amsterdam) over werkdruk op de technische afdeling

Zakendoen | BNR

Play Episode Listen Later Dec 12, 2022 109:08


Het grootste gesubsidieerde theatergezelschap van Nederland annuleert voorstellingen vanwege de hoge werkdruk op de technische afdeling. Wat is er volgens de directeur belangrijker: het eeuwige streven naar vernieuwend theater met technische snufjes, of een normale werkdruk voor technisch personeel? Te gast is Clayde Menso, directeur van Internationaal Theater Amsterdam. Macro met Boot Elke dag een intrigerende gedachtewisseling over de stand van de macro-economie. Op maandag en vrijdag gaat presentator Thomas van Zijl in gesprek met econoom Arnoud Boot, de rest van de week praat Van Zijl met econoom Edin Mujagić. Economenpanel De koopkracht van huishoudens daalt het huidige en het volgende jaar met zo'n 4 procent, zo berekent het Centraal Planbureau. Dit ondanks het prijsplafond voor gas. En: wat is een omgekeerde rentecurve en waarom duidt dat op een recessie? Dat en meer bespreken we om 13.00 in het Economenpanel met: - Marieke Blom, hoofdeconoom bij ING; - Bas Jacobs, hoogleraar economie aan de Vrije Universiteit van Amsterdam. Luister l Economenpanel Geniaal of Onzinnig Welk bedrijf droomt er niet van: het introduceren van een geniaal product of een briljante dienst. Maar wat in de ogen van het bedrijf in kwestie geweldig is, kan zo maar onzinnig zijn. Bij ons te gast is vandaag Marjolein Helder, algemeen directeur van Plant-e. Krapte op de arbeidsmarkt Het personeelstekort neemt steeds grotere proporties aan. Talloze vacatures blijven onvervuld en werkgevers zitten met de handen in hun haar. Wat betekent de krappe arbeidsmarkt voor ondernemers, hr-directeuren en bestuurders? Wat zijn mogelijke innovatieve en creatieve oplossingen? En waar zijn al die werknemers eigenlijk gebleven? Elke maandag ga ik op zoek naar antwoorden op deze vragen in de gesprekkenserie Zakendoen op een krappe arbeidsmarkt. Met vandaag een bondig gesprek over open hiring. Bij ons te gast is Jos van Delft, van Start Foundation. Zakenpartner Ze studeerde aan het University College in Utrecht, ging aan de slag als journalist maar wilde toch liever met tastbare producten werken. Daarom volgde ze een traineeship bij Ahold. Op de supermarktvloer zag ze hoeveel eten er verspild werd. Dit bracht haar op het idee een restaurant te openen wat gebruik maakt van voedsel dat anders zou worden weggegooid. Dit was de start van Instockmarket. De zakenpartner deze week is Selma Seddik, mede-oprichter van Instockmarket. Contact & Abonneren BNR Zakendoen zendt elke werkdag live uit van 12:00 tot 14:30 uur. Je kunt de redactie bereiken via e-mail en Twitter. Abonneren op de podcast van BNR Zakendoen kan via bnr.nl/zakendoen, of via Apple Podcast en Spotify.See omnystudio.com/listener for privacy information.

Bach van de Dag
Franks Klassieke Wonderkamer -‘Utrecht, 1636'

Bach van de Dag

Play Episode Listen Later Dec 12, 2022 14:46


Je dagelijkse portie muzikale verwondering. Welkom in mijn wonderkamer, vol muziek, verhalen en voorwerpen. Een muzikale reis door eeuwen, windstreken en genres. ‘Utrecht, 1636' Over Lawes, Descartes en Saenredam Meer zien? Klik hier (https://www.nporadio4.nl/klassiek/podcasts/9b75b58c-b59e-4742-ab29-39ff76d8f106/dit-hoor-je-deze-week-in-franks-klassieke-wonderkamer-week-50-12-t-m-16-december) William Lawes Consort Set A 5  Hesperion XXI (album: Lawes Consort Sets in Five & Six Parts) Franks Klassieke Wonderkamer is straks niet meer via de Bach van de Dag feed te beluisteren. Niks missen? Abonneer je dan op de podcast Franks Klassieke Wonderkamer.

De Grote Podcastlas

Van gortdroge woestijn tot ondoordringbaar regenwoud en van Lima's betonnen jungle tot machtige zesduizenders: welkom in Peru, een van de meest karakteristieke landen van Zuid-Amerika. Natuurlijk, wij vinden elk land de moeite waard. Maar Peru is heel erg de moeite waard. En niet alleen om de natuurlijke schoonheid. Is het Peruaanse landschap een lichaam, dan draagt het als een sieraad de overblijfselen van oude rijken van oorspronkelijke bewoners. Niet uit het oog, dus ook niet uit het hart. In de eeuwen daarna zette de hele wereld voet aan wal in Peru. Dat zorgde voor een bloedige geschiedenis, maar ook voor een keuken om van te watertanden. Je hoort het, we hebben veel te bespreken.Deze aflevering wordt gesponsord door Bit Academy.We zijn nooit volledig, wel origineel. Geen experts, maar wel liefhebbers. Hebben we tóch iets verkeerd gezegd of zijn we iets cruciaals vergeten? Volg ons en laat het weten.Neem vooral ook even een kijkje op onze gloednieuwe website.

Hou Je Vastgoed
S4E04 - Er was eens… een stratenmaker

Hou Je Vastgoed

Play Episode Listen Later Dec 3, 2022 32:08


Aan tafel zit Jason Blackmore, Jan de Boer voor intimi. Hij ging van het letterlijk werken met stenen naar praten over stenen. Van stratenmaker naar vastgoedman. Na een aantal jaar makelen bij DTZ Zadelhoff maakte hij de overstap naar G&S Vastgoed, waar hij nu directeur is. Voor Maarten is Jason geen onbekende - ze werken momenteel samen aan een groot project in Utrecht.

Pushing Pediatrics
Episode 24: Case Files Friday - Cases 6, 7, 8, 9

Pushing Pediatrics

Play Episode Listen Later Dec 2, 2022 27:17


Join Sheila and Sara for their Case Files Friday. Case studies will help your studying by mimicking the PCS exam test question style! Use the information you already know and apply it to these cases. This week, we cover four cases, all on cerebral palsy to coordinate with episode 23! Need more help? Consider a Medbridge subscription. More content plus FOUR practice exams to get you ready for TEST DAY! Medbridge Affiliate code: https://www.medbridgeeducation.com/pushing-pediatrics Resources: Pelletier, E. S., & Jobst, E. E. (2015). Case Files in Physical Therapy Pediatrics. McGraw-Hill Education. van Brussel M, van der Net J, Hulzebos E, Helders PJ, Takken T. The Utrecht approach to exercise in chronic childhood conditions: the decade in review. Pediatr Phys Ther. 2011 Spring;23(1):2-14. doi: 10.1097/PEP.0b013e318208cb22. PMID: 21304338. --- Support this podcast: https://anchor.fm/pushingpediatrics/support

The Sanskrit Studies Podcast
15. Robert Zydenbos | The Life of Sanskrit Traditions

The Sanskrit Studies Podcast

Play Episode Listen Later Dec 1, 2022 104:15


My guest this month is Robert Zydenbos, who is Professor of Modern Indology at the LMU Munich. (Full disclosure: we thus are colleagues!)His first point of contact with Indian languages and philosophies was through Collier's Encyclopaedia. It introduced him to such ideas as rebirth, a concept found in various traditions (see e.g. here, here or here)His first degree was in Indian Studies at the University of Utrecht, at an institute that developed into a centre of Tantric Studies and that has in the meantime been closed.  His teachers included Jan Gonda, T. Goudriaan , Henk Bodewitz,  Leen van Dalen , George Chemparathy, Kamil Zvelebil, Sanjukta Gupta, Karel van Kooij. He did his PhD and much subsequent work in Mysore, where he frequently visited the university and the Oriental Research Institute; and whereas his early interest in Jainism brought him to Karnataka, he also studied religious currents such as Vīraśaivism and Mādhva Vaiṣṇavism. Through his close acquaintance with Bannanje Govindacharya, he began working on Madhvācārya and his writings, also those concerning the Bhagavadgītā. (The article he mentions may be found here.)He would use the SSPRG, the Sanskrit Studies Podcast Research Grant, to learn Old Javanese. For anyone interested in learning about Sanskrit  for the first time, he recommends Pierre-Sylvain Filliozat's Le sanskrit/The Sanskrit Language.

Pixelated Playgrounds
Sokpop Selection ft. Stacklands and Simmiland

Pixelated Playgrounds

Play Episode Listen Later Nov 30, 2022


Bryan and Josh have both long been intrigued by the prolific and quirky “Video Game Development Boy Band” hailing from Utrecht, Netherlands and calling themselves Sokpop. Given the recent breakout success of the group's title, Stacklands, they decided to dive in and survey the vast back catalogue of projects that Sokpop has created. For those unaware: Sokpop is a 4 person video game development collective which has given itself an ambitious mission: launch a new game every 2 weeks. The games vary in size, shape, and scope but generally adhere to a ‘House Style' that features low-res colorful visuals and cute, chunky animations. While the discussion primarily concerns Stacklands and another title, Simmiland, from a gameplay and mechanics perspective, Bryan and Josh discuss Sokpop's approach more broadly in this podcast we're calling Sokpop Selection.Three Word Reviews:Bryan - Curious Collective CreationJosh - Rapid Fire ReleaseShow Notes:Sokpop's Patreon PageGame Design Perspective: Stacklands by JoshGames Discussed: Stacklands, Simmiland, Luckitown, Tile Tale, Pocket Watch, White Lavender, Rook, KingPins, Sproots

Daybreak
Daybreak for November 29, 2022

Daybreak

Play Episode Listen Later Nov 29, 2022 51:22


Tuesday of the First Week of Advent Saint of the Day: St. Radbod of Utrecht, 850-917; great grandson of the last paga King of Friesland, Holland; became bishop of Utrecht in 900; know for his aid to the poor, and for his poetry; forced to move his see to France, due to invasion by the Danes, and died there Office of Readings and Morning Prayer for 11/29/22 Gospel: Luke 10:21-24

Philosophical Disquisitions
101 - Pistols, Pills, Pork and Ploughs: How Technology Changes Morality

Philosophical Disquisitions

Play Episode Listen Later Nov 28, 2022


It's clear that human social morality has gone through significant changes in the past. But why? What caused these changes? In this episode, I chat to Jeroen Hopster from the University of Utrecht about this topic. We focus, in particular, on a recent paper that Jeroen co-authored with a number of colleagues about four historical episodes of moral change and what we can learn from them. That paper, from which I take the title of this podcast, was called 'Pistols, Pills, Pork and Ploughs' and, as you might imagine, looks at how specific technologies (pistols, pills, pork and ploughs) have played a key role in catalysing moral change. You can download the episode here or listen below. You can also subscribe on Apple Podcasts, Stitcher, Spotify and other podcasting services (the RSS feed is here). #mc_embed_signup{background:#fff; clear:left; font:14px Helvetica,Arial,sans-serif; } /* Add your own MailChimp form style overrides in your site stylesheet or in this style block. We recommend moving this block and the preceding CSS link to the HEAD of your HTML file. */ Subscribe to the newsletter

New Books in Law
Frans Camphuijsen, "Scripting Justice in Late Medieval Europe: Legal Practice and Communication in the Law Courts of Utrecht, York and Paris" (Amsterdam UP, 2022)

New Books in Law

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